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https://www.readbyqxmd.com/read/28419027/athletes-intending-to-use-sports-supplements-are-more-likely-to-respond-to-a-placebo
#1
Philip Hurst, Abby Foad, Damian Coleman, Chris Beedie
PURPOSE: We investigated associations between athletes' use of sport supplements and their responsiveness to placebo and nocebo interventions. METHODS: Participants (n=627) reported their intention to use, and actual use of, sport supplements. They then completed a 5x20m repeat sprint protocol in the baseline condition, prior to being randomized to one of three treatments. Participants in the positive-belief treatment were administered an inert capsule described as a potent supplement which would improve sprint performance...
April 18, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28371755/are-media-reports-able-to-cause-somatic-symptoms-attributed-to-wifi-radiation-an-experimental-test-of-the-negative-expectation-hypothesis
#2
Anne-Kathrin Bräscher, Koen Raymaekers, Omer Van den Bergh, Michael Witthöft
People suffering from idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) experience numerous non-specific symptoms that they attribute to EMF. The cause of this condition remains vague and evidence shows that psychological rather than bioelectromagnetic mechanisms are at work. We hypothesized a role of media reports in the etiology of IEI-EMF and investigated how somatosensory perception is affected. 65 healthy participants were instructed that EMF exposure can lead to enhanced somatosensory perception...
March 31, 2017: Environmental Research
https://www.readbyqxmd.com/read/28363152/placebo-and-nocebo-reactions-in-randomized-trials-of-pharmacological-treatments-for-persistent-depressive-disorder-a-meta-regression-analysis
#3
REVIEW
Ramona Meister, Alessa Jansen, Martin Härter, Yvonne Nestoriuc, Levente Kriston
BACKGROUND: We aimed to investigate placebo and nocebo reactions in randomized controlled trials (RCT) of pharmacological treatments for persistent depressive disorder (PDD). METHODS: We conducted a systematic electronic search and included RCTs investigating antidepressants for the treatment of PDD. Outcomes were the number of patients experiencing response and remission in placebo arms (=placebo reaction). Additional outcomes were the incidence of patients experiencing adverse events and related discontinuations in placebo arms (=nocebo reaction)...
March 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28341522/cognitive-schemas-in-placebo-and-nocebo-responding-role-of-autobiographical-memories-and-expectations
#4
Danielle J P Bartels, Antoinette I M van Laarhoven, Naomi Heijmans, Dirk Hermans, Elise Debeer, Peter C M van de Kerkhof, Andrea W M Evers
PURPOSE: Placebo effects are presumed to be based on one's expectations and previous experience with regard to a specific treatment. The purpose of this study was to investigate the role of the specificity and valence of memories and expectations with regard to itch in experimentally induced placebo and nocebo itch responses. It was expected that cognitive schemas with more general and more negative memories and expectations with regard to itch contribute to less placebo itch responding...
March 21, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28321201/placebo-and-nocebo-effects-the-advantage-of-measuring-expectations-and-psychological-factors
#5
Nicole Corsi, Luana Colloca
Several studies have explored the predictability of placebo and nocebo individual responses by investigating personality factors and expectations of pain decreases and increases. Psychological factors such as optimism, suggestibility, empathy and neuroticism have been linked to placebo effects, while pessimism, anxiety and catastrophizing have been associated to nocebo effects. We aimed to investigate the interplay between psychological factors, expectations of low and high pain and placebo hypoalgesia and nocebo hyperalgesia...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28289539/contextually-aided-recovery-care-a-scientific-theory-for-innate-healing
#6
Dave Newell, Lise R Lothe, Timothy J L Raven
BACKGROUND: The chiropractic profession emerged when scientific explanations for causes of health and disease were still in infancy and the co-existence of notions such as innate healing and vitalism were perhaps admissible within such a historical context. Notwithstanding, within the scientific culture of the 21(st) Century all healthcare paradigms require evidential support which in regard these early concepts are in large part, absent. Nevertheless, a large body of emerging scientific evidence supports the existence of innate healing phenomena that may explain a plethora of clinical outcomes observed during chiropractic care...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28277699/harnessing-the-placebo-effect-exploring-the-influence-of-physician-characteristics-on-placebo-response
#7
Lauren C Howe, J Parker Goyer, Alia J Crum
OBJECTIVE: Research on placebo/nocebo effects suggests that expectations can influence treatment outcomes, but placebo/nocebo effects are not always evident. This research demonstrates that a provider's social behavior moderates the effect of expectations on physiological outcomes. METHODS: After inducing an allergic reaction in participants through a histamine skin prick test, a health care provider administered a cream with no active ingredients and set either positive expectations (cream will reduce reaction) or negative expectations (cream will increase reaction)...
March 9, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28258765/current-insights-in-the-placebo-and-nocebo-phenomena
#8
EDITORIAL
Seetal Dodd
No abstract text is available yet for this article.
February 28, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28246492/the-effects-of-distraction-on-symptoms-during-drug-provocation-test
#9
Songul Cildag, Taskin Senturk, Gokhan Sargin
BACKGROUND: Some patients may have psychosomatic complaints due to their previous experiences during the drug hypersensitivity reaction. Worry about being hurt due to an administered drug is termed nocebo effect, which is the opposite of the placebo effect. In our study, we investigated the effect of distraction on symptoms during drug provocation test. METHODS: Our study included 112 patients who underwent DPTs for alternative purposes in our clinic. Previous hypersensitivity reactions of all the patients had objective signs...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28244667/non-coeliac-gluten-sensitivity
#10
REVIEW
Peter R Gibson, Gry I Skodje, Knut E A Lundin
Irritable bowel syndrome-like symptoms in response to wheat ingestion is common and well described, but whether the reaction is due to gluten (i.e., non-coeliac gluten sensitivity), other wheat proteins, or FODMAPs (mostly fructans) alone or in combinations has not been clearly defined. Exclusion of coeliac disease in the presence of negative serology, and normal villous architecture but increased density of intraepithelial lymphocytes on duodenal biopsies, is difficult. Furthermore, the confidence by which a positive diagnosis is made or non-coeliac gluten sensitivity is excluded by blinded placebo-controlled rechallenge with wheat protein is reduced by strong nocebo responses generally found in patients with self-reported non-coeliac gluten sensitivity...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28237673/the-placebo-and-nocebo-phenomena-their-clinical-management-and-impact-on-treatment-outcomes
#11
REVIEW
Victor Chavarria, João Vian, Círia Pereira, João Data-Franco, Brisa S Fernandes, Michael Berk, Seetal Dodd
PURPOSE: This overview focuses on placebo and nocebo effects in clinical trials and routine care. Our goal was to propose strategies to improve outcomes in clinical practice, maximizing placebo effects and reducing nocebo effects, as well as managing these phenomena in clinical trials. METHODS: A narrative literature search of PubMed was conducted (January 1980-September 2016). Systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on placebo or nocebo effects in clinical practice were included in the qualitative synthesis...
February 22, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28210930/emotion-specific-nocebo-effects-an-fmri-study
#12
Anne Schienle, Carina Höfler, Sonja Übel, Albert Wabnegger
The neurobiological mechanisms of nocebos are still poorly understood. Thirty-eight women participated in a 'smell study' using functional magnetic resonance imaging. They were presented with an odorless stimulus (distilled water) together with the verbal suggestion that this fluid has an aversive odor which enhances disgust feelings. The nocebo was presented while the participants viewed disgusting, fear-inducing, and neutral images. Participants' affective and neuronal responses during nocebo administration were compared with those in a control condition without nocebo...
February 16, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28197000/impact-of-an-educational-module-in-antidepressant-naive-patients-prescribed-antidepressants-for-depression-pilot-proof-of-concept-randomized-controlled-trial
#13
Annie P John, Nagendra Madan Singh, Nagarajaiah, Chittaranjan Andrade
BACKGROUND: Patients are educated about their illness and its treatment at the time of diagnosis. However, little is known about how much of this education is retained and how it influences knowledge about, attitudes toward, and experiences with medication in antidepressant-naive patients with depression. METHODS: Antidepressant-naive outpatients with International Classification of Diseases-10 dysthymia or mild to moderate depression, who were advised antidepressant monotherapy, were randomized to control (n = 22) or intervention (n = 17) groups...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28177183/learning-by-experience-visceral-pain-related-neural-and-behavioral-responses-in-a-classical-conditioning-paradigm
#14
A Icenhour, F Labrenz, C Ritter, N Theysohn, M Forsting, U Bingel, S Elsenbruch
BACKGROUND: Studies investigating mechanisms underlying nocebo responses in pain have mainly focused on negative expectations induced by verbal suggestions. Herein, we addressed neural and behavioral correlates of nocebo responses induced by classical conditioning in a visceral pain model. METHODS: In two independent studies, a total of 40 healthy volunteers underwent classical conditioning, consisting of repeated pairings of one visual cue (CS(High) ) with rectal distensions of high intensity, while a second cue (CS(Low) ) was always followed by low-intensity distensions...
February 8, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28165442/antimicrobial-efficacy-of-probiotic-containing-toothpastes-an-in-vitro-evaluation
#15
Miro Klarić, Vjekoslav Mandić, Sanjin Lovrić, Martina Krešić Ćorić, Nikolina Zovko
Most people have heard of the placebo effect, while relatively few have heard of nocebo, even within the circles of medical staff. Placebo effect means positive results by treatment via pharmacological inert substances. In contrast to placebo, by nocebo effect, due to negative beliefs and expectations, opposite results are achieved. Said in a more formal manner, what a sick person expects, unfortunately, he/she most often gets. It is a fact that a high number of medical staff is still uninterested in placebo and nocebo effects, although they would benefit from them...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28162564/-327-quantitative-eeg-markers-of-pain-facilitation-by-nocebo
#16
S Albu, H Linsenbardt, M Meagher
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161116/a-review-of-the-theoretical-and-biological-understanding-of-the-nocebo-and-placebo-phenomena
#17
REVIEW
Seetal Dodd, Olivia M Dean, João Vian, Michael Berk
PURPOSE: Placebos are commonly used in experimental and patient populations and are known to influence treatment outcomes. The mechanism of action of placebos has been investigated by several researchers. This review investigates the current knowledge regarding the theoretical and biological underpinning of the nocebo and placebo phenomena. METHOD: Literature was searched using PubMed using the following keywords: nocebo, placebo, μ-opioid, dopamine, conditioning, and expectancy...
February 1, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28116120/distant-delivery-of-a-mindfulness-based-intervention-for-people-with-parkinson-s-disease-the-study-protocol-of-a-randomised-pilot-trial
#18
A Bogosian, C S Hurt, D Vasconcelos E Sa, J V Hindle, L McCracken, P Cubi-Molla
BACKGROUND: Psychological difficulties, especially depression and anxiety, are the most prevalent non-motor symptoms in Parkinson's disease. Pharmacological treatments for these conditions appear relatively ineffective in Parkinson's disease. Mindfulness courses are increasingly popular and recognised as effective for managing emotional states, and there is growing evidence for the effectiveness of mindfulness courses for people with long-term medical conditions. With this exploratory pilot trial, we want to assess the feasibility of the procedures and processes, including recruitment, most appropriate outcome measure(s), acceptability of type and number of measures, potential nocebo effects, and potential effectiveness and cost-effectiveness of a specially adapted distance-delivered mindfulness-based intervention in people affected by Parkinson's disease...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28106308/measuring-expectation-of-pain-contingent-negative-variation-in-placebo-and-nocebo-effects
#19
A Piedimonte, G Guerra, S Vighetti, E Carlino
BACKGROUND: Expectation is an important mechanism underlying placebo response. Here, we analysed expectation of placebo hypoalgesia and nocebo hyperalgesia by using, for the first time, the contingent negative variation (CNV), also known as expectancy wave. METHODS: Subjects were presented a green or red cue followed by a train of either non painful or painful electrical stimuli, and expected hypoalgesia after the green and hyperalgesia after the red cue. In experiment 1, expectation was reinforced using a conditioning procedure whereby the green and red cues were paired with non painful and painful stimuli, respectively (acquisition)...
May 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28105896/cathechol-o-methyltransferase-val158met-polymorphism-is-associated-with-nocebo-effects-but-not-with-methotrexate-intolerance-in-patients-with-juvenile-idiopathic-arthritis
#20
B Hügle, A Scheuern, S Dollinger, N Fischer, J-P Haas
No abstract text is available yet for this article.
January 20, 2017: Scandinavian Journal of Rheumatology
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