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Katie A Butera, Steven Z George, Paul A Borsa, Geoffrey C Dover
OBJECTIVES: Transcutaneous electrical nerve stimulation (TENS) is commonly used for reducing musculoskeletal pain to improve function. However, peripheral nerve stimulation using TENS can alter muscle motor output. Few studies examine motor outcomes following TENS in a human pain model. Therefore, this study investigates the influence of TENS sensory stimulation primarily on motor output (strength) and secondarily on pain and disability following exercise-induced delayed-onset muscle soreness (DOMS)...
March 5, 2018: Pain Practice: the Official Journal of World Institute of Pain
Matt Richardson, Gina Isbister, Brad Nicholson
BACKGROUND: Theories concerning the aetiology of functional neurological symptom disorder (FNSD; also known as conversion disorder) have historically inferred that psychological factors or dissociative states underlie patients' symptoms. Current psychological models of functional neurological symptoms suggest that some type of 'top-down' representations/beliefs are activated automatically (without conscious awareness), leading to symptoms. It is assumed that these representations or beliefs are similar to the idea 'I am neurologically damaged', as in our clinical experience, almost all patients have some reason to doubt the integrity of their neurological system...
February 21, 2018: Behavioural and Cognitive Psychotherapy
A A van Bodegraven, N W Boone
No abstract text is available yet for this article.
March 2018: Alimentary Pharmacology & Therapeutics
Carina Höfler, Andreas Gremsl, Anne Schienle
The knowledge about effects of placebos and nocebos on specific visual attention processes is still very limited. In the present eye-tracking study, it was analyzed if a nocebo (sham transcranial magnetic stimulation) is able to elicit left-sided attentional deficits (pseudo-neglect). Fifty-two healthy participants performed a search task on the computer, once with and once without the nocebo. Indicators of left-biased search behavior (e.g. fixation count, reaction times for left vs. right-sided target detection) and affective state (e...
February 1, 2018: International Journal of Psychophysiology
Rebecca K Webster, John Weinman, G James Rubin
OBJECTIVES: To investigate a range of possible predictors of nocebo responses to medicines. DESIGN: Prospective cohort study. METHODS: In total, 203 healthy adult volunteers completed measures concerning demographics, psychological factors, medicine-related beliefs, baseline symptoms, and symptom expectations before taking a sham pill, described as 'a well-known tablet available without prescription' that was known to be associated with several side effects...
February 5, 2018: British Journal of Health Psychology
Julia Schmitz, Sandra Kamping, Janine Wiegratz, Maike Müller, Jan Stork, Luana Colloca, Herta Flor, Regine Klinger
Introduction: Patient information leaflets on pain medication primarily list side effects while positive effects and action mechanisms remain underrepresented. Nocebo research has shown that negative instructions can lower analgesic effects. Objectives: Research on information leaflets and their influence on mood, memory of side effects, and intake behavior of healthy participants is needed. Methods: To determine the ratio of positive to negative phrases, 18 information leaflets of common, over-the-market analgesics were examined of which 1 was selected...
November 2017: Pain Reports (Baltimore, Md.)
Carina Höfler, Albert Wabnegger, Anne Schienle
There is growing evidence that placebos are able to influence visual perception. A previous functional magnetic resonance imaging (fMRI) study on the processing of disgust images demonstrated that a 'disgust placebo' (inert pill administered with the verbal suggestion of an anti-nausea medication) reduced visual cortex activity and connectivity. In the present fMRI investigation, we examined corresponding visual effects of a 'disgust nocebo' (an odorless substance introduced as an aversive smell that enhances disgust feelings)...
2018: Journal of Integrative Neuroscience
N W Boone, L Liu, M J Romberg-Camps, L Duijsens, C Houwen, P H M van der Kuy, R Janknegt, R Peeters, R B M Landewé, B Winkens, A A van Bodegraven
BACKGROUND: In clinical practice, non-medical switching of biological medication may provoke nocebo effects due to unexplained deterioration of therapeutic benefits. Indication extrapolation, idiosyncratic reactions, and interchangeability remain challenged in clinical practice after biosimilar approval by the European Medicines Agency. The principle of "first do no harm" may be challenged in a patient when switching from originator to biosimilar biological. AIM: To describe the 1-year results of a pragmatic study on infliximab biosimilar implementation in immune-mediated inflammatory disease patients on the basis of shared decision-making under effectiveness and safety monitoring...
January 24, 2018: European Journal of Clinical Pharmacology
Giacomo Rossettini, Elisa Carlino, Marco Testa
Placebo and nocebo effects are embodied psycho-neurobiological responses capable of modulating pain and producing changes at different neurobiological, body at perceptual and cognitive levels. These modifications are triggered by different contextual factors (CFs) presented in the therapeutic encounter between patient and healthcare providers, such as healing rituals and signs. The CFs directly impact on the quality of the therapeutic outcome: a positive context, that is a context characterized by the presence of positive CFs, can reduce pain by producing placebo effects, while a negative context, characterized by the presence of negative CFs, can aggravate pain by creating nocebo effects...
January 22, 2018: BMC Musculoskeletal Disorders
Soyeon Cheon, Hi-Joon Park, Younbyoung Chae, Hyangsook Lee
BACKGROUND: While full disclosure of information on placebo control in participant information leaflets (PILs) in a clinical trial is ethically required during informed consent, there have been concerning voices such complete disclosures may increase unnecessary nocebo responses, breach double-blind designs, and/or affect direction of trial outcomes. Taking an example of acupuncture studies, we aimed to examine what participants are told about placebo controls in randomized, placebo-controlled trials, and how it may affect blinding and trial outcomes...
January 18, 2018: BMC Medical Research Methodology
Chittaranjan Andrade
Many studies have shown that educating patients about the potential adverse effects of a drug can increase the chances that those adverse effects will be experienced. Studies have further shown that how such information is communicated can also impact this nocebo risk. Additionally, information provided through patient education can influence treatment efficacy, perhaps by moderating the placebo response. There is therefore a need to optimize the manner in which patients are educated about their medications so that placebo-related benefits are enhanced and nocebo-related harm is minimized...
November 2017: Journal of Clinical Psychiatry
Daniel Michael Doleys
BACKGROUND: The prescribing of opioids in the chronic pain setting is often based on the pharmacodynamics, pharmacokinetics, and pharmacogenetics of the drug obtained during development and clinical trials. However, the effectiveness of opioids varies widely and often appears to bear no relationship to the aforementioned variables. The impact of philosophical issues and psychological factors on determining how clinically effective opioid therapy is has often been over looked. OBJECTIVES: This manuscript provides a selective review and narrative summary of the philosophical issues and psychological factors which can influence opioid effectiveness...
November 2017: Pain Physician
Wacław M Adamczyk, Oskar Saulicz, Edward Saulicz, Kerstin Luedtke
Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. NCT03021278), healthy participants were exposed to 1 of 3 experimental conditions: acute, nociceptive low back pain induced by saline injection, a sham injection (without piercing the skin) potentially inducing nocebo pain, or no intervention...
November 13, 2017: Pain
Philip D Shenefelt
No abstract text is available yet for this article.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
Majed Chamsi-Pasha, Mohammed Ali Albar, Hassan Chamsi-Pasha
The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms...
October 2017: Avicenna Journal of Medicine
Missanga F van de Sand, Mareike M Menz, Christian Sprenger, Christian Büchel
It has been shown repeatedly that perceiving itch-related pictures or listening to a lecture on itch can enhance itch sensation and scratching behaviour (Niemeier and Gieler, 2000; Holle et al., 2012; Lloyd et al., 2013), indicating that itch is strongly influenced by expectations. Using fMRI, we investigated the neural correlates of the itch-related nocebo effect in healthy male and female human subjects. Itch sensation on the left forearm was induced by cutaneous histamine application and thermally modulated, with cooling leading to higher itch...
February 1, 2018: NeuroImage
Paul Enck, Younbyoung Chae, Sigrid Elsenbruch
The investigation of the placebo and the nocebo effect and their mechanisms has a rather short history of less than 20 years, especially in gastroenterology, and only the last 5 years have resulted in substantial improvement of understanding. Placebo refers to symptom improvement following a treatment, nocebo to the opposite, symptom worsening. Among the factors driving this progress are traditional psychological models derived from learning (conditioning) theory bridging into clinical science, new animal models to investigate the pharmacology of placebo analgesia, and novel study designs to overcome limitations of traditional randomized and placebo-controlled study designs in drug testing...
December 2017: Current Opinion in Pharmacology
Benedek T Tihanyi, Eszter Ferentzi, Florian Beissner, Ferenc Köteles
Tingling is a bodily sensation experienced under a variety of conditions from everyday experiences to experimental and therapeutic situations. It can be induced by both peripheral or afferent (external stimulation, peripheral pathology) and higher cognitive (expectation) processes. The paper summarizes the current scientific knowledge on the neurophysiological and psychological concomitants of the tingling sensation. Four possible models are identified and presented: the afferent, the attention-disclosed, the attention-evoked, and the efferent model...
October 30, 2017: Consciousness and Cognition
Lieke Tweehuysen, Bart J F van den Bemt, Iris L van Ingen, Alphons J L de Jong, Willemijn H van der Laan, Frank H J van den Hoogen, Alfons A den Broeder
OBJECTIVE: To evaluate drug survival, effectiveness, pharmacokinetics, immunogenicity, and safety in daily practice after transitioning treatment from original reference infliximab (Remicade [REM]) to a biosimilar infliximab (CT-P13 [Remsima; Inflectra]) in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. METHODS: Of the initial 222 REM-treated patients, 192 agreed to transition to CT-P13 and were included in this multicenter prospective cohort study...
January 2018: Arthritis & Rheumatology
Regine Klinger, Maxie Blasini, Julia Schmitz, Luana Colloca
INTRODUCTION: Nocebo-induced algesic responses occurring within clinical contexts present a challenge for health care practitioners working in the field of pain medicine. OBJECTIVES: Following the recent research on algesic nocebo effects, the scope of this review is to develop ethically acceptable strategies to help avoid, or at least reduce, nocebo responses within clinical settings. METHODS: We reviewed relevant clinical studies that depict how patient-practitioner interactions may contribute to the reduction of nocebo responses...
March 2017: Pain Reports (Baltimore, Md.)
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