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https://www.readbyqxmd.com/read/29149154/philosophical-issues-and-psychological-variables-that-influence-the-determination-of-opioid-effectiveness-a-narrative-review
#1
Daniel Michael Doleys
BACKGROUND: The prescribing of opioids in the chronic pain setting is often based on the pharmacodynamics, pharmacokinetics, and pharmacogenetics of the drug obtained during development and clinical trials. However, the effectiveness of opioids varies widely and often appears to bear no relationship to the aforementioned variables. The impact of philosophical issues and psychological factors on determining how clinically effective opioid therapy is has often been over looked. OBJECTIVES: This manuscript provides a selective review and narrative summary of the philosophical issues and psychological factors which can influence opioid effectiveness...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29140929/tactile-acuity-dys-function-in-acute-nociceptive-low-back-pain-a-doubleblind-experiment
#2
Wacław M Adamczyk, Oskar Saulicz, Edward Saulicz, Kerstin Luedtke
Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. NCT03021278), healthy participants were exposed to one of three experimental conditions: acute, nociceptive low back pain induced by saline injection, a sham-injection (without piercing the skin) potentially inducing nocebo pain, or no intervention...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29121131/noxious-nocebos-in-dermatology
#3
Philip D Shenefelt
No abstract text is available yet for this article.
September 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29119079/minimizing-nocebo-effect-pragmatic-approach
#4
REVIEW
Majed Chamsi-Pasha, Mohammed Ali Albar, Hassan Chamsi-Pasha
The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy. The frequency of adverse events can dramatically increase by informing patients about the possible side effects of the treatment, and by negative expectations on the part of the patient. Patients who were told that they might experience sexual side effects after treatment with β-blocker drugs reported these symptoms between three and four times more often than patients in a control group who were not informed about these symptoms...
October 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29107770/nocebo-induced-modulation-of-cerebral-itch-processing-an-fmri-study
#5
Missanga F van de Sand, Mareike M Menz, Christian Sprenger, Christian Büchel
It has been shown repeatedly that perceiving itch-related pictures or listening to a lecture on itch can enhance itch sensation and scratching behaviour (Niemeier and Gieler, 2000; Holle et al., 2012; Lloyd et al., 2013), indicating that itch is strongly influenced by expectations. Using fMRI, we investigated the neural correlates of the itch-related nocebo effect in healthy male and female human subjects. Itch sensation on the left forearm was induced by cutaneous histamine application and thermally modulated, with cooling leading to higher itch...
October 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29102743/novel-designs-and-paradigms-to-study-the-placebo-response-in-gastroenterology
#6
REVIEW
Paul Enck, Younbyoung Chae, Sigrid Elsenbruch
The investigation of the placebo and the nocebo effect and their mechanisms has a rather short history of less than 20 years, especially in gastroenterology, and only the last 5 years have resulted in substantial improvement of understanding. Placebo refers to symptom improvement following a treatment, nocebo to the opposite, symptom worsening. Among the factors driving this progress are traditional psychological models derived from learning (conditioning) theory bridging into clinical science, new animal models to investigate the pharmacology of placebo analgesia, and novel study designs to overcome limitations of traditional randomized and placebo-controlled study designs in drug testing...
October 26, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29096941/the-neuropsychophysiology-of-tingling
#7
REVIEW
Benedek T Tihanyi, Eszter Ferentzi, Florian Beissner, Ferenc Köteles
Tingling is a bodily sensation experienced under a variety of conditions from everyday experiences to experimental and therapeutic situations. It can be induced by both peripheral or afferent (external stimulation, peripheral pathology) and higher cognitive (expectation) processes. The paper summarizes the current scientific knowledge on the neurophysiological and psychological concomitants of the tingling sensation. Four possible models are identified and presented: the afferent, the attention-disclosed, the attention-evoked, and the efferent model...
October 30, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29045077/subjective-complaints-as-main-reason-for-biosimilar-discontinuation-after-open-label-transitioning-from-originator-to-biosimilar-infliximab
#8
Lieke Tweehuysen, Bart J F van den Bemt, Iris L van Ingen, Alphons J L de Jong, Willemijn H van der Laan, Frank H J van den Hoogen, Alfons A den Broeder
OBJECTIVE: To evaluate drug survival, effectiveness, pharmacokinetics, immunogenicity and safety after transitioning treatment from originator infliximab (Remicade(®) , REM) to biosimilar infliximab (CT-P13) in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis in daily practice. METHODS: 192 of 222 REM-treated patients agreed to transition to CT-P13 and were included in this multicenter prospective cohort study. Change in DAS28-CRP, BASDAI, CRP and (anti-) infliximab levels were assessed after six months and adverse events (AEs) were documented...
October 18, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29034363/nocebo-effects-in-clinical-studies-hints-for-pain-therapy
#9
Regine Klinger, Maxie Blasini, Julia Schmitz, Luana Colloca
INTRODUCTION: Nocebo-induced algesic responses occurring within clinical contexts present a challenge for health care practitioners working in the field of pain medicine. OBJECTIVES: Following the recent research on algesic nocebo effects, the scope of this review is to develop ethically acceptable strategies to help avoid, or at least reduce, nocebo responses within clinical settings. METHODS: We reviewed relevant clinical studies that depict how patient-practitioner interactions may contribute to the reduction of nocebo responses...
March 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29032452/treatment-outcomes-with-biosimilars-be-aware-of-the-nocebo-effect
#10
REVIEW
Mourad F Rezk, Burkhard Pieper
Over the years, biologic agents have proven their importance in the management of chronic autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Biosimilars, which are biologic medicines, are highly similar to approved biologic medicines, and are comprehensively developed and rigorously tested to ensure efficacy and safety are similar to the reference product. A broader armamentarium of biosimilars is expected to improve patients' access to safe and effective biologic medicines, thus offering benefits to healthcare systems around the globe...
December 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29025685/generalization-of-learned-pain-modulation-depends-on-explicit-learning
#11
Leonie Koban, Daniel Kusko, Tor D Wager
The experience of pain is strongly influenced by contextual and socio-affective factors, including learning from previous experiences. Pain is typically perceived as more intense when preceded by a conditioned cue (CSHIGH) that has previously been associated with higher pain intensities, compared to cues associated with lower intensities (CSLOW). In three studies (total N=134), we tested whether this learned pain modulation generalizes to perceptually similar cues (Studies 1 and 2) and conceptually similar cues (Study 3)...
October 9, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28986900/patients-preferences-for-headache-acute-and-preventive-treatment
#12
Dimos D Mitsikostas, Ioanna Belesioti, Chryssa Arvaniti, Euthymia Mitropoulou, Christina Deligianni, Elina Kasioti, Theodoros Constantinidis, Manolis Dermitzakis, Michail Vikelis
BACKGROUND: We aimed to explore patients' preferences for headache treatments with a self-administered questionnaire including the Q-No questionnaire for nocebo. METHODS: Questionnaires from 514 outpatients naïve to neurostimulation and monoclonal antibodies were collected. RESULTS: Patients assessed that the efficacy of a treatment is more important than safety or route of administration. They preferred to use an external neurostimulation device for both acute (67...
October 6, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28983051/interactions-between-brain-and-spinal-cord-mediate-value-effects-in-nocebo-hyperalgesia
#13
A Tinnermann, S Geuter, C Sprenger, J Finsterbusch, C Büchel
Value information about a drug, such as the price tag, can strongly affect its therapeutic effect. We discovered that value information influences adverse treatment outcomes in humans even in the absence of an active substance. Labeling an inert treatment as expensive medication led to stronger nocebo hyperalgesia than labeling it as cheap medication. This effect was mediated by neural interactions between cortex, brainstem, and spinal cord. In particular, activity in the prefrontal cortex mediated the effect of value on nocebo hyperalgesia...
October 6, 2017: Science
https://www.readbyqxmd.com/read/28983038/nocebo-effects-can-make-you-feel-pain
#14
COMMENT
Luana Colloca
No abstract text is available yet for this article.
October 6, 2017: Science
https://www.readbyqxmd.com/read/28971165/nocebo-and-pain-an-overview-of-the-psychoneurobiological-mechanisms
#15
Maxie Blasini, Nicole Corsi, Regine Klinger, Luana Colloca
INTRODUCTION: Nocebo effects are defined as adverse events related to negative expectations and learning processes that are involved in the modulation of the descending pain pathways. Research over the last couple of decades has illustrated that behavioral, psychoneurobiological and functional changes occur during nocebo-induced pain processing. OBJECTIVES: We aimed to review published human and non-human research on algesia and hyperalgesia resulting from negative expectations and nocebo effects...
March 2017: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/28958840/women-s-perceptions-and-treatment-patterns-related-to-contraception-results-of-a-survey-of-us-women
#16
Anita L Nelson, Stephen Cohen, Alex Galitsky, Mark Hathaway, Dale Kappus, Majid Kerolous, Kiren Patel, Linda Dominguez
OBJECTIVES: The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN: We administered a nationally-representative, web-based survey of US women aged 16 to 50 years currently using (N=1656) or had previously used (N=1448) prescription contraception, or who had never used it but would consider using it in the future (N=103)...
September 25, 2017: Contraception
https://www.readbyqxmd.com/read/28943814/helping-children-cope-with-medical-tests-and-interventions
#17
Elvira V Lang, Jacqueline Viegas, Chris Bleeker, Jörgen Bruhn, Geffen Geert-Jan van
Medical procedures and tests become a challenge when anxiety and pain make it difficult for the patient to cooperate or remain still when needed. Fortunately a short intervention with hypnoidal language at the onset of a procedure induces a positive and sustained change in the way pain and anxiety are processed. While anesthesia may appear to be a simple solution to eliminate pain, the adverse effects of pre-anesthesia anxiety on postoperative behavior and recovery are often not fully appreciated. This paper discusses options for self-hypnotic relaxation that are applicable to interactions with children...
March 2017: Journal of Radiology Nursing
https://www.readbyqxmd.com/read/28940099/influence-of-depressed-patients-expectations-prior-to-electroconvulsive-therapy-on-its-effectiveness-and-tolerability-exp-ect-a-prospective-study
#18
Lisa Krech, Michael Belz, Matthias Besse, Isabel Methfessel, Dirk Wedekind, David Zilles
Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive disorders. Though there are known clinical predictors of response (e.g., higher age, presence of psychotic symptoms), there is a lack of knowledge concerning the impact of patients' expectations on treatment outcome and tolerability in terms of possible placebo/nocebo effects. In 31 patients with unipolar or bipolar depressive disorder, we used a questionnaire to investigate the patients' expectations of ECT effectiveness and tolerability prior to and in the course of the treatment...
September 22, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28910291/minimizing-nocebo-effects-by-conditioning-with-verbal-suggestion-a-randomized-clinical-trial-in-healthy-humans
#19
RANDOMIZED CONTROLLED TRIAL
Danielle J P Bartels, Antoinette I M van Laarhoven, Michiel Stroo, Kim Hijne, Kaya J Peerdeman, A Rogier T Donders, Peter C M van de Kerkhof, Andrea W M Evers
Nocebo effects, i.e., adverse treatment effects which are induced by patients' expectations, are known to contribute to the experience of physical symptoms such as pain and itch. A better understanding of how to minimize nocebo responses might eventually contribute to enhanced treatment effects. However, little is known about how to reduce nocebo effects. In the current randomized controlled study, we tested whether nocebo effects can be minimized by positive expectation induction with respect to electrical and histaminic itch stimuli...
2017: PloS One
https://www.readbyqxmd.com/read/28832394/nocebo-effect-in-meni%C3%A3-re-s-disease-a-meta-analysis-of-placebo-controlled-randomized-controlled-trials
#20
Panagiotis A Dimitriadis, Panagiotis Zis
OBJECTIVE: To estimate the frequency and strength of nocebo effects in trials for Menière disease (MD). DATA SOURCES: A literature search was conducted in PUBMED. The search terms we used were " Menière or Menière's," "treatment," and "placebo." Limitations included article type to be Clinical Trial or Randomized Controlled Trial, text availability to be Full text, Species to be Humans and Language to be English. STUDY SELECTION: We included placebo-controlled pharmaceutical RCTs that referred specifically to MD and recruited at least 10 adults in each arm...
October 2017: Otology & Neurotology
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