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https://www.readbyqxmd.com/read/28106308/measuring-expectation-of-pain-contingent-negative-variation-in-placebo-and-nocebo-effects
#1
A Piedimonte, G Guerra, S Vighetti, E Carlino
BACKGROUND: Expectation is an important mechanism underlying placebo response. Here, we analysed expectation of placebo hypoalgesia and nocebo hyperalgesia by using, for the first time, the contingent negative variation (CNV), also known as expectancy wave. METHODS: Subjects were presented a green or red cue followed by a train of either non painful or painful electrical stimuli, and expected hypoalgesia after the green and hyperalgesia after the red cue. In experiment 1, expectation was reinforced using a conditioning procedure whereby the green and red cues were paired with non painful and painful stimuli, respectively (acquisition)...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28105896/cathechol-o-methyltransferase-val158met-polymorphism-is-associated-with-nocebo-effects-but-not-with-methotrexate-intolerance-in-patients-with-juvenile-idiopathic-arthritis
#2
B Hügle, A Scheuern, S Dollinger, N Fischer, J-P Haas
No abstract text is available yet for this article.
January 20, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28058499/-rheumatoid-arthritis
#3
REVIEW
D Aletaha, A Kerschbaumer
Therapy reduction in rheumatoid arthritis (RA) is still a challenge for physicians as well as for patients. Effective therapy with subsequent achievement of low disease activity or even remission is achievable for numerous patients using currently available treatment options. Therapy discontinuation has therefore become a hot topic and the risk of exacerbation of well-controlled RA must be weighed against the medical and economic benefits of reducing or even discontinuing therapy. This article gives a review of data regarding tapering of therapy in RA, focusing on conventional disease-modifying antirheumatic drug (DMARD) monotherapy, reduction of conventional therapy under continuing therapy with biologics and discontinuation of biologics...
January 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28054312/latent-inhibition-reduces-nocebo-nausea-even-without-deception
#4
V F Quinn, E J Livesey, B Colagiuri
BACKGROUND: Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea. Interventions that retard conditioning may therefore be able to reduce nocebo nausea. PURPOSE: To test whether 'latent inhibition', where pre-exposing cues in the absence of an outcome retards subsequent learning about those cues, could reduce nocebo nausea in healthy adults. METHODS: We examined this possibility using a Galvanic Vestibular Stimulation (GVS) model of nausea in healthy participants, with pre-exposure to the treatment cues achieved using a placebo version of GVS...
January 4, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27998345/stuart-justman-the-nocebo-effect-overdiagnosis-and-its-costs-new-york-palgrave-macmillan-2015-pp-%C3%A2-xi-272-hardback-79-99-isbn-%C3%A2-987-1-137-52328-0
#5
https://www.readbyqxmd.com/read/27978780/context-as-a-drug-some-consequences-of-placebo-research-for-primary-care
#6
P Lucassen, F Olesen
OBJECTIVE: On the basis of emerging research evidence, this review aims to discuss the importance of the context surrounding the doctor-patient encounter for the success of treatment. DESIGN AND SETTING: Discussion paper based on placebo-nocebo and pain studies conducted in the western world. MAIN OUTCOME MEASURES: Literature-based theory about impact of communication elements on seriousness of symptoms in clinical practice. RESULTS: The therapeutic outcome seems to be impacted by rituals around a clinical encounter and by the doctor patient communication and relation...
December 2016: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/27978485/nocebo-effect-in-refractory-partial-epilepsy-during-pre-surgical-monitoring-systematic-review-and-meta-analysis-of-placebo-controlled-clinical-trials
#7
Panagiotis Zis, Faiza Shafiq, Dimos-Dimitrios Mitsikostas
PURPOSE: Nocebo is very prevalent among neurological diseases resulting in low adherence and treatment outcome. We sought to examine the AEs following placebo administration in Randomized Controlled Studies (RCTs) for Epilepsy. METHOD: After a systematic Medline search for RCTs for Epilepsy pharmacological treatments, we assessed the number of discontinuations because of placebo intolerance. RESULTS: Data were extracted from 4 RCTs fulfilling our search criteria...
December 7, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27965612/can-psychological-expectation-models-be-adapted-for-placebo-research
#8
REVIEW
Winfried Rief, Keith J Petrie
Placebo responses contribute substantially to the effect and clinical outcome of medical treatments. Patients' expectations have been identified as one of the major mechanisms contributing to placebo effects. However, to date a general theoretical framework to better understand how patient expectations interact with features of medical treatment has not been developed. In this paper we outline an expectation model that can be used as framework for experimental studies on both placebo and nocebo mechanisms. This model is based on psychological concepts of expectation development, expectation maintenance, and expectation change within the typical paradigms used in placebo research...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27919521/unsolved-forgotten-and-ignored-features-of-the-placebo-response-in-medicine
#9
REVIEW
Paul Enck, Sibylle Klosterhalfen, Katja Weimer
PURPOSE: We aimed to identify topics of research that have been neglected, undervalued, or overseen in the past 2 decades of placebo/nocebo research. METHODS: A highly specialized literature database containing >3200 articles on the placebo or nocebo effects or response was screened for articles covering placebo effects in nutrition, sports medicine, physical therapy, and psychotherapy; for article covering gender, age, and culture as influencing factors; for articles dealing with long-term outcome, multimodality; and for articles related to technical (eHealth, mHealth) aspects of placebo effects...
December 2, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27852171/nocebo-effects-in-practice-methotrexate-myths-and-misconceptions
#10
Mark H Arnold, Jane Bleasel, Inam Haq
No abstract text is available yet for this article.
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27789385/nocebo-hyperalgesia-and-the-startle-response
#11
Per M Aslaksen, Ole Åsli, Morten Øvervoll, Espen Bjørkedal
BACKGROUND: The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect. METHODS: A design with four groups was employed; the participants were randomized into either a placebo group, a natural history group, or into two nocebo groups. The participants in the placebo and nocebo groups received suggestions of pain decrease or pain increase, together with a placebo or nocebo cream applied to the lower arm, respectively...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27754297/lbos-01-04-the-true-incidence-of-statin-related-adverse-events-in-hypertensive-patients-revealed-by-comparison-of-blinded-and-un-blinded-use-of-statin-in-the-anglo-scandinavian-cardiac-outcomes-trial-ascot
#12
Peter Sever, Ajay Gupta, David Thompson, Andrew Whitehouse, Tim Collier, Bjorn Dahlof, Neil Poulter
OBJECTIVE: To test the hypothesis that adverse effects of statins are only reported in excess in observational studies and not in blinded randomized trials. DESIGN AND METHOD: We collated all reported AEs in hypertensive patients in the Lipid-Lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA) during the randomised, double-blind phase (when atorvastatin was compared with placebo) and the subsequent non-randomised un-blinded LLA-extension phase (when patients were offered open-label statin)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27719874/nature-of-the-placebo-and-nocebo-effect-in-relation-to-functional-neurologic-disorders
#13
E Carlino, A Piedimonte, F Benedetti
Placebos have long been considered a nuisance in clinical research, for they have always been used as comparators for the validation of new treatments. By contrast, today they represent an active field of research, and, due to the involvement of many mechanisms, the study of the placebo effect can actually be viewed as a melting pot of concepts and ideas for neuroscience. There is not a single placebo effect, but many, with different mechanisms across different medical conditions and therapeutic interventions...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27706855/placebo-and-nocebo-effects-as-major-components-of-the-treatment-of-itch
#14
Laurent Misery, Jean-Luc Carré
No abstract text is available yet for this article.
January 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/27643837/harnessing-positive-placebo-effect-and-minimize-negative-nocebo-effect-the-art-of-a-healing-profession
#15
Xiulu Ruan, Lien Tran, Alan David Kaye
No abstract text is available yet for this article.
October 2016: Pain
https://www.readbyqxmd.com/read/27643295/lbos-01-04-the-true-incidence-of-statin-related-adverse-events-in-hypertensive-patients-revealed-by-comparison-of-blinded-and-un-blinded-use-of-statin-in-the-anglo-scandinavian-cardiac-outcomes-trial-ascot
#16
Peter Sever, Ajay Gupta, David Thompson, Andrew Whitehouse, Tim Collier, Bjorn Dahlof, Neil Poulter
OBJECTIVE: To test the hypothesis that adverse effects of statins are only reported in excess in observational studies and not in blinded randomized trials. DESIGN AND METHOD: We collated all reported AEs in hypertensive patients in the Lipid-Lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA) during the randomised, double-blind phase (when atorvastatin was compared with placebo) and the subsequent non-randomised un-blinded LLA-extension phase (when patients were offered open-label statin)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27584317/placebo-and-nocebo-effects-of-a-purported-ergogenic-aid-on-repeat-sprint-performance-1278-board-8-june-2-8-00-am-10-00-am
#17
Chris J Beedie, Philip Hurst, Damian Coleman, Abby Foad
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27580494/lessons-learned-from-nocebo-effects-in-clinical-trials-for-pain-conditions-and-neurodegenerative-disorders
#18
Martina Amanzio, Sara Palermo, Ina Skyt, Lene Vase
It has been demonstrated that patients in the placebo arm of a clinical trial may experience adverse events (AEs), which may lead to nonadherence and dropout. However, so far, it is unknown to which extent this phenomenon is observed consistently across different diseases such as pain and neurodegenerative disorders.The current review shows for the first time that different diseases share a common risk for patients in terms of a negative outcome: a large percentage of placebo-treated patients experience AEs in pain conditions (up to 59%) and neurodegenerative disorders (up to 66%)...
October 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27580156/effect-of-ischemic-preconditioning-on-endurance-performance-does-not-surpass-placebo
#19
Jeann L Sabino-Carvalho, Thiago R Lopes, Tiago Obeid-Freitas, Thiago N Ferreira, José E Succi, Antônio C Silva, Bruno M Silva
PURPOSE: Recent studies have reported ischemic preconditioning (IPC) can acutely improve endurance exercise performance in athletes. However, placebo and nocebo effects have not been sufficiently controlled, and the effect on aerobic metabolism parameters that determine endurance performance (e.g., oxygen cost of running, lactate threshold, and maximal oxygen uptake [V˙O2max]) has been equivocal. Thus, we circumvented limitations from previous studies to test the effect of IPC on aerobic metabolism parameters and endurance performance in well-trained runners...
January 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27578103/the-nocebo-effect-in-the-context-of-statin-intolerance
#20
EDITORIAL
Jonathan A Tobert, Connie B Newman
The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon that is under-appreciated in cardiovascular medicine. It refers to adverse events, usually purely subjective, that result from expectations of harm from a drug, placebo, other therapeutic intervention or a nonmedical situation. These expectations can be driven by many factors including the informed consent form in a clinical trial, warnings about adverse effects communicated by clinicians when prescribing a drug, and information in the media about the dangers of certain treatments...
July 2016: Journal of Clinical Lipidology
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