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https://www.readbyqxmd.com/read/28910291/minimizing-nocebo-effects-by-conditioning-with-verbal-suggestion-a-randomized-clinical-trial-in-healthy-humans
#1
Danielle J P Bartels, Antoinette I M van Laarhoven, Michiel Stroo, Kim Hijne, Kaya J Peerdeman, A Rogier T Donders, Peter C M van de Kerkhof, Andrea W M Evers
Nocebo effects, i.e., adverse treatment effects which are induced by patients' expectations, are known to contribute to the experience of physical symptoms such as pain and itch. A better understanding of how to minimize nocebo responses might eventually contribute to enhanced treatment effects. However, little is known about how to reduce nocebo effects. In the current randomized controlled study, we tested whether nocebo effects can be minimized by positive expectation induction with respect to electrical and histaminic itch stimuli...
2017: PloS One
https://www.readbyqxmd.com/read/28832394/nocebo-effect-in-meni%C3%A3-re-s-disease-a-meta-analysis-of-placebo-controlled-randomized-controlled-trials
#2
Panagiotis A Dimitriadis, Panagiotis Zis
OBJECTIVE: To estimate the frequency and strength of nocebo effects in trials for Menière disease (MD). DATA SOURCES: A literature search was conducted in PUBMED. The search terms we used were " Menière or Menière's," "treatment," and "placebo." Limitations included article type to be Clinical Trial or Randomized Controlled Trial, text availability to be Full text, Species to be Humans and Language to be English. STUDY SELECTION: We included placebo-controlled pharmaceutical RCTs that referred specifically to MD and recruited at least 10 adults in each arm...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28831271/a-systematic-review-of-sex-differences-in-the-placebo-and-the-nocebo-effect
#3
REVIEW
Sara M Vambheim, Magne Arve Flaten
OBJECTIVES: The present review investigated whether there are systematic sex differences in the placebo and the nocebo effect. METHODS: A literature search was conducted in multiple electronic databases. Studies were included if the study compared a group or condition where a placebo was administered to a natural history group or similar cohort. RESULTS: Eighteen studies were identified - 12 on placebo effects and 6 on nocebo effects. Chi-square tests revealed that 1) males responded more strongly to placebo treatment, and females responded more strongly to nocebo treatment, and 2) males responded with larger placebo effects induced by verbal information, and females responded with larger nocebo effects induced by conditioning procedures...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28827535/effect-of-genetic-information-and-information-about-caffeine-content-on-caffeine-withdrawal-symptoms
#4
Llewellyn Mills, Ilan Dar-Nimrod, Ben Colagiuri
This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdrawal response during abstinence; (2) belief that one has consumed caffeine leads to a reduction in withdrawal symptoms when no caffeine is consumed. Regular coffee drinkers were given a bogus genetic test and were told either that they had tested positive or negative for a gene related to withdrawal...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28750001/classical-conditioning-without-verbal-suggestions-elicits-placebo-analgesia-and-nocebo-hyperalgesia
#5
Przemysław Bąbel, Elżbieta A Bajcar, Wacław Adamczyk, Paweł Kicman, Natalia Lisińska, Karolina Świder, Luana Colloca
The aim of this study was to examine the relationships among classical conditioning, expectancy, and fear in placebo analgesia and nocebo hyperalgesia. A total of 42 healthy volunteers were randomly assigned to three groups: placebo, nocebo, and control. They received 96 electrical stimuli, preceded by either orange or blue lights. A hidden conditioning procedure, in which participants were not informed about the meaning of coloured lights, was performed in the placebo and nocebo groups. Light of one colour was paired with pain stimuli of moderate intensity (control stimuli), and light of the other colour was paired with either nonpainful stimuli (in the placebo group) or painful stimuli of high intensity (in the nocebo group)...
2017: PloS One
https://www.readbyqxmd.com/read/28727700/therapeutic-role-of-placebo-evolution-of-a-new-paradigm-in-understanding-research-and-clinical-practice
#6
Laxmaiah Manchikanti, Mark V Boswell, Alan D Kaye, Standiford Helm Ii, Joshua A Hirsch
Research into interventional techniques in managing chronic spinal pain continues to be challenging, mystifying, confusing, and biased. Insight, or lack thereof, into placebo and nocebo phenomena contributes mightily to these difficulties. Unfortunately, placebo-nocebo responses are the subject of numerous controversies and challenges from not only a research perspective, but also clinical perspective. While interventionalists consider the biggest threat to interventional pain management research is inappropriate and outdated interpretation of the data, a greater problem is the misuse of the placebo response in research, with the declaration that all and everything as a placebo effect: with a misinterpretation of the nature of the placebo the, associated conclusions can be inaccurate...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28722815/influence-of-morphine-and-naloxone-on-pain-modulation-in-rheumatoid-arthritis-chronic-fatigue-syndrome-fibromyalgia-and-controls-a-double-blind-randomized-placebo-controlled-cross-over-study
#7
Linda Hermans, Jo Nijs, Patrick Calders, Luc De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, Tine Roman De Mettelinge, Joanna Tuynman, Mira Meeus
BACKGROUND: Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown. METHODS: A randomized, double-blind, placebo-controlled cross-over trial was carried out. Ten CFS/FM patients, 11 RA patients and 20 controls were randomly allocated to the experimental (10 mg morphine or 0.2 mg/ml Naloxone) and placebo (2 ml Aqua) group...
July 19, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28719223/from-bench-to-bedside-converting-placebo-research-into-belief-activation
#8
Jen Green, Heather Wright
Research on the placebo effect contains important elements that can be harnessed to improve clinical care. This paper proposes a new term, "Belief Activation," to describe the deliberate use of placebo effect tools by both patients and clinicians to catalyze healing. Belief Activation includes, but is not limited to, maximizing patient and practitioner expectations, classical and social conditioning, spirituality and prayer/intention, therapeutic relationship, healing environments, and minimizing the nocebo effect...
August 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28702702/-placebo-and-nocebo-how-can-they-be-used-or-avoided
#9
REVIEW
E Hansen, N Zech, K Meissner
The expectations of patients enhance the probability of their occurrence and are thereby the main triggers for inducing placebo and nocebo responses. Strong placebo effects are not only regularly observed in pharmaceutical and non-pharmaceutical sham treatment in placebo controlled studies but also make a considerable contribution to any real treatment. The accompanying words are essential to ensure maximum impact of drugs and other forms of treatment. They should contain positive expressions instead of negations...
July 12, 2017: Der Internist
https://www.readbyqxmd.com/read/28700816/comparative-nocebo-effects-in-older-patients-enrolled-in-cancer-therapeutic-trials-observations-from-a-446-patient-cohort
#10
Jared C Foster, Jennifer G Le-Rademacher, Josephine L Feliciano, Ajeet Gajra, Drew K Seisler, Ronald DeMatteo, Jacqueline M Lafky, Arti Hurria, Hyman B Muss, Harvey J Cohen, Aminah Jatoi
BACKGROUND: A nocebo is an inert substance associated with adverse events. Although previous studies have examined the positive (placebo) effects of such inert substances, few have examined negative (nocebo) adverse event profiles, particularly in older patients who have higher morbidity and can experience frequent and severe adverse events from cancer therapy. METHODS: This study focused on placebo/nocebo-exposed patients who participated in 2 double-blind, placebo-controlled, cancer therapeutic studies, namely, North Central Cancer Therapy Group trial NCCTG 97-24-51 and American College of Surgeons Oncology Group trial Z9001, with the goal of reporting the comparative, age-based adverse event rates, as reported during the conduct of these trials...
July 12, 2017: Cancer
https://www.readbyqxmd.com/read/28663259/what-trial-participants-need-to-be-told-about-placebo-effects-to-give-informed-consent-a-survey-to-establish-existing-knowledge-among-patients-with-back-pain
#11
John Hughes, Maddy Greville-Harris, Cynthia A Graham, George Lewith, Peter White, Felicity L Bishop
INTRODUCTION: Patients require an accurate knowledge about placebos and their possible effects to ensure consent for placebo-controlled clinical trials is adequately informed. However, few previous studies have explored patients' baseline (ie, pretrial recruitment) levels of understanding and knowledge about placebos. The present online survey aimed to assess knowledge about placebos among patients with a history of back pain. DESIGN: A 15-item questionnaire was constructed to measure knowledge about placebos...
June 29, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28661738/nonmaleficence-nondisclosure-and-nocebo-response-to-open-peer-commentaries
#12
John T Fortunato, Jason Adam Wasserman, Daniel Londyn Menkes
No abstract text is available yet for this article.
July 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28655010/nocebo-effect-may-account-for-statin-adverse-events
#13
Anita Slomski
No abstract text is available yet for this article.
June 27, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28651483/induced-beliefs-about-a-fictive-energy-drink-influences-200-m-sprint-performance
#14
Ricardo de la Vega, Sara Alberti, Roberto Ruíz-Barquín, István Soós, Attila Szabo
Placebo and nocebo effects occur in response to subjective expectations and their subsequent neural actions. Research shows that information shapes expectations that, consequently, influence people's behaviour. In this study, we examined the effects of a fictive and inert green colour energy drink provided for three groups (n = 20/group) with different information. The first group was led to expect that the drink augments running performance (positive information), the second group was led to expect that the drink may or may not improve performance (partial-positive information), while the third group was told that earlier research could not demonstrate that the drink improves performance (neutral/control)...
September 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28618140/how-does-the-side-effect-information-in-patient-information-leaflets-influence-peoples-side-effect-expectations-a-cross-sectional-national-survey-of-18-to-65-year-olds-in-england
#15
Rebecca K Webster, John Weinman, G James Rubin
OBJECTIVES: To establish how the terms recommended by the European Commission to describe side-effect risk in patient information leaflets (PILs) influences expectations of side-effects and to identify factors associated with these side-effect expectations. DESIGN: A cross-sectional online survey was carried out by a market research company. SETTING: Data were collected in England between 18th March and 1st April 2016. PARTICIPANTS: A total of 1003 adults aged between 18 and 65...
June 15, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28595945/role-of-placebo-effects-in-pain-and-neuropsychiatric-disorders
#16
REVIEW
Annabelle M Belcher, Sergi Ferré, Pedro E Martinez, Luana Colloca
The placebo (and the nocebo) effect is a powerful determinant of health outcomes in clinical disease treatment and management. Efforts to completely eradicate placebo effects have shifted dynamically, as increasingly more researchers are tuned to the potentially beneficial effects of incorporating those uncontrollable placebo effects into clinical therapeutic strategies. In this review, we highlight the major findings from placebo research, elucidating the main neurobiological systems and candidate determinants of the placebo phenomenon, and illustrate a perspective that can effectively frame future research on the topic...
June 8, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28593798/nocebo-in-motor-neuron-disease-systematic-review-and-meta-analysis-of-placebo-controlled-clinical-trials
#17
Faiza Shafiq, Dimos-Dimitrios Mitsikostas, Panagiotis Zis
INTRODUCTION: Nocebo is very prevalent among neurological disorders, resulting in low adherence and treatment outcome. We sought to examine the AEs following placebo administration in placebo-controlled randomised clinical trials (RCTs) for motor neuron disease (MND). METHODS: After a systematic literature search for RCTs for MND pharmacotherapy treatments, we assessed the number of discontinuations because of placebo intolerance. RESULTS: Data were extracted from 12 RCTs fulfilling our search criteria...
June 8, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28562635/physicians-beliefs-about-placebo-and-nocebo-effects-in-antidepressants-an-online-survey-among-german-practitioners
#18
Lea Kampermann, Yvonne Nestoriuc, Meike C Shedden-Mora
BACKGROUND: While substantial placebo and nocebo effects have been documented in antidepressant clinical trials, physicians' awareness of the nonspecific effects in routine antidepressant treatment remains unclear. The study investigated physicians' beliefs and explanatory models regarding the desired effects and undesired side effects of antidepressants, with specific emphasis on nonspecific effects accounted for by placebo and nocebo mechanisms. METHODS: An online survey was conducted among 87 physicians (40...
2017: PloS One
https://www.readbyqxmd.com/read/28537836/recognizing-the-nocebo-benefits-patient-care-but-demands-greater-cultural-competency-in-the-clinic
#19
Antoinette P Joseph, Paul H Mason, Narelle Warren, Isaac Atley
No abstract text is available yet for this article.
June 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28537834/when-respecting-autonomy-is-harmful-a-clinically-useful-approach-to-the-nocebo-effect
#20
John T Fortunato, Jason Adam Wasserman, Daniel Londyn Menkes
Nocebo effects occur when an adverse effect on the patient arises from the patient's own negative expectations. In accordance with informed consent, providers often disclose information that results in unintended adverse outcomes for the patient. While this may adhere to the principle of autonomy, it violates the doctrine of "primum non nocere," given that side-effect disclosure may cause those side effects. In this article we build off previous work, particularly by Wells and Kaptchuk ( 2012 ) and by Cohen ( 2013 ), to suggest ethical guidelines that permit nondisclosure in the case when a nocebo effect is likely to occur on of the basis of nonmaleficence...
June 2017: American Journal of Bioethics: AJOB
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