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https://www.readbyqxmd.com/read/27919521/unsolved-forgotten-and-ignored-features-of-the-placebo-response-in-medicine
#1
REVIEW
Paul Enck, Sibylle Klosterhalfen, Katja Weimer
PURPOSE: We aimed to identify topics of research that have been neglected, undervalued, or overseen in the past 2 decades of placebo/nocebo research. METHODS: A highly specialized literature database containing >3200 articles on the placebo or nocebo effects or response was screened for articles covering placebo effects in nutrition, sports medicine, physical therapy, and psychotherapy; for article covering gender, age, and culture as influencing factors; for articles dealing with long-term outcome, multimodality; and for articles related to technical (eHealth, mHealth) aspects of placebo effects...
December 2, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27852171/nocebo-effects-in-practice-methotrexate-myths-and-misconceptions
#2
Mark H Arnold, Jane Bleasel, Inam Haq
No abstract text is available yet for this article.
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27789385/nocebo-hyperalgesia-and-the-startle-response
#3
Per M Aslaksen, Ole Åsli, Morten Øvervoll, Espen Bjørkedal
BACKGROUND: The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect. METHODS: A design with four groups was employed; the participants were randomized into either a placebo group, a natural history group, or into two nocebo groups. The participants in the placebo and nocebo groups received suggestions of pain decrease or pain increase, together with a placebo or nocebo cream applied to the lower arm, respectively...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27754297/lbos-01-04-the-true-incidence-of-statin-related-adverse-events-in-hypertensive-patients-revealed-by-comparison-of-blinded-and-un-blinded-use-of-statin-in-the-anglo-scandinavian-cardiac-outcomes-trial-ascot
#4
Peter Sever, Ajay Gupta, David Thompson, Andrew Whitehouse, Tim Collier, Bjorn Dahlof, Neil Poulter
OBJECTIVE: To test the hypothesis that adverse effects of statins are only reported in excess in observational studies and not in blinded randomized trials. DESIGN AND METHOD: We collated all reported AEs in hypertensive patients in the Lipid-Lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA) during the randomised, double-blind phase (when atorvastatin was compared with placebo) and the subsequent non-randomised un-blinded LLA-extension phase (when patients were offered open-label statin)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27719874/nature-of-the-placebo-and-nocebo-effect-in-relation-to-functional-neurologic-disorders
#5
E Carlino, A Piedimonte, F Benedetti
Placebos have long been considered a nuisance in clinical research, for they have always been used as comparators for the validation of new treatments. By contrast, today they represent an active field of research, and, due to the involvement of many mechanisms, the study of the placebo effect can actually be viewed as a melting pot of concepts and ideas for neuroscience. There is not a single placebo effect, but many, with different mechanisms across different medical conditions and therapeutic interventions...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27706855/placebo-and-nocebo-effects-as-major-components-of-the-treatment-of-itch
#6
Laurent Misery, Jean-Luc Carré
In a viewpoint, Andrea Evers underlines how expectations and learned immune function can o ptimize dermatological treatments through the placebo effect, or induce opposite effects through nocebo effects. Going back to the first theories trying to explain the mechanisms of drugs addiction, she mentions patient expectations as well as conditioning processes. Placebo and nocebo effects are commonly studied indirectly in controlled double-blind trials. Their effects on objective symptoms are limited but are higher on subjective symptoms...
October 5, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27643837/harnessing-positive-placebo-effect-and-minimize-negative-nocebo-effect-the-art-of-a-healing-profession
#7
Xiulu Ruan, Lien Tran, Alan David Kaye
No abstract text is available yet for this article.
October 2016: Pain
https://www.readbyqxmd.com/read/27643295/lbos-01-04-the-true-incidence-of-statin-related-adverse-events-in-hypertensive-patients-revealed-by-comparison-of-blinded-and-un-blinded-use-of-statin-in-the-anglo-scandinavian-cardiac-outcomes-trial-ascot
#8
Peter Sever, Ajay Gupta, David Thompson, Andrew Whitehouse, Tim Collier, Bjorn Dahlof, Neil Poulter
OBJECTIVE: To test the hypothesis that adverse effects of statins are only reported in excess in observational studies and not in blinded randomized trials. DESIGN AND METHOD: We collated all reported AEs in hypertensive patients in the Lipid-Lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-LLA) during the randomised, double-blind phase (when atorvastatin was compared with placebo) and the subsequent non-randomised un-blinded LLA-extension phase (when patients were offered open-label statin)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27584317/placebo-and-nocebo-effects-of-a-purported-ergogenic-aid-on-repeat-sprint-performance-1278-board-8-june-2-8-00-am-10-00-am
#9
Chris J Beedie, Philip Hurst, Damian Coleman, Abby Foad
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27580494/lessons-learned-from-nocebo-effects-in-clinical-trials-for-pain-conditions-and-neurodegenerative-disorders
#10
Martina Amanzio, Sara Palermo, Ina Skyt, Lene Vase
It has been demonstrated that patients in the placebo arm of a clinical trial may experience adverse events (AEs), which may lead to nonadherence and dropout. However, so far, it is unknown to which extent this phenomenon is observed consistently across different diseases such as pain and neurodegenerative disorders.The current review shows for the first time that different diseases share a common risk for patients in terms of a negative outcome: a large percentage of placebo-treated patients experience AEs in pain conditions (up to 59%) and neurodegenerative disorders (up to 66%)...
October 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27580156/effect-of-ischemic-preconditioning-on-endurance-performance-does-not-surpass-placebo
#11
Jeann L C Sabino-Carvalho, Thiago R Lopes, Tiago O Freitas, Thiago H N Ferreira, José E Succi, Antônio C Silva, Bruno M Silva
PURPOSE: Recent studies have reported ischemic preconditioning (IPC) can acutely improve endurance exercise performance in athletes. However, placebo and nocebo effects have not been sufficiently controlled, and the effect on aerobic metabolism parameters that determine endurance performance [e.g., oxygen cost of running, lactate threshold, and maximal oxygen uptake (V[Combining Dot Above]O2max)] has been equivocal. Thus, we circumvented limitations from previous studies to test the effect of IPC on aerobic metabolism parameters and endurance performance in well-trained runners...
August 30, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27578103/the-nocebo-effect-in-the-context-of-statin-intolerance
#12
EDITORIAL
Jonathan A Tobert, Connie B Newman
The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon that is under-appreciated in cardiovascular medicine. It refers to adverse events, usually purely subjective, that result from expectations of harm from a drug, placebo, other therapeutic intervention or a nonmedical situation. These expectations can be driven by many factors including the informed consent form in a clinical trial, warnings about adverse effects communicated by clinicians when prescribing a drug, and information in the media about the dangers of certain treatments...
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27564058/expectation-influences-the-interruptive-function-of-pain-behavioural-and-neural-findings
#13
C Sinke, K Schmidt, K Forkmann, U Bingel
BACKGROUND: Expectations can dramatically influence the perception of pain, as has been shown in placebo analgesia or nocebo hyperalgesia. Here, we investigated the role of expectation on the interruptive function of pain - the negative consequences of pain on cognitive task performance - in 42 healthy human subjects. METHODS: Verbal and written instructions were used to manipulate the subjects' expectation of how pain would influence their task performance in an established visual categorization task which was performed with or without concomitant painful thermal stimulation during 3T fMRI scanning...
August 26, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27562424/expectation-of-nocebo-hyperalgesia-affects-eeg-alpha-activity
#14
Sergiu Albu, Mary W Meagher
Changes in EEG activity have been related to clinical and experimental pain. Expectation of a negative outcome can lead to pain enhancement (nocebo hyperalgesia) and can alter the response to therapeutic interventions. The present study characterizes EEG alteration related to pain facilitation by nocebo. Thirty healthy subjects were randomly assigned to the nocebo or control group. Five-minute EEG was recorded under: resting state, tonic innocuous heat and tonic noxious heat before and after the application of a sham inert cream to the non-dominant volar forearm combined with cognitive manipulation...
August 22, 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27551051/is-it-best-to-expect-the-worst-influence-of-patients-side-effect-expectations-on-endocrine-treatment-outcome-in-a-2-year-prospective-clinical-cohort-study
#15
Y Nestoriuc, P von Blanckenburg, F Schuricht, A J Barsky, P Hadji, U-S Albert, W Rief
BACKGROUND: This study aims to determine the role of patient expectations as potentially modifiable factor of side-effects, quality of life, and adherence to endocrine treatment of breast cancer. PATIENTS AND METHODS: A 2-year prospective clinical cohort study was conducted in routine primary care with postoperative patients with hormone-receptor-positive breast cancer, scheduled to start adjuvant endocrine treatment. Structured patient-reported assessments of side-effects, side-effect expectations, quality of life, and adherence took place during the first week post-surgery and after 3 and 24 months of endocrine treatment...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27523634/suspected-nonceliac-gluten-sensitivity-confirmed-in-few%C3%A2-patients-after-gluten-challenge-in-double-blind-placebo-controlled-trials
#16
Javier Molina-Infante, Antonio Carroccio
A double-blind, placebo-controlled, gluten challenge has been proposed to confirm a diagnosis of nonceliac gluten sensitivity (NCGS) in patients without celiac disease who respond to a gluten-free diet. To determine the accuracy of this approach, we analyzed data from 10 double-blind, placebo-controlled, gluten-challenge trials, comprising 1312 adults. The studies varied in the duration of the challenge (range, 1 d to 6 wk), daily doses for the gluten challenge (range, 2-52 g; 3 studies administered <8 g/d), and composition of the placebo (gluten-free products, xylose, whey protein, rice, or corn starch containing fermentable carbohydrates)...
August 12, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27489170/using-the-placebo-effect-how-expectations-and-learned-immune-function-can-optimize-dermatological-treatments
#17
Andrea W M Evers
The role of placebo and nocebo effects - i.e. positive or negative treatment effects that are entirely a consequence of the patient's expectations and beliefs about a treatment outcome in terms of efficacy, safety, usability, or side effects - has been shown for almost all types of diseases and physiological response systems. Evidence for the relevance of placebo and nocebo effects in dermatology is also increasing, particularly for symptoms of itch and learned (conditioned) immune function. In addition, increasing knowledge is available about the neurobiological mechanisms of action, such as the role of the dopaminergic system...
August 4, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27484431/-primum-non-nocebo-and-the-obligatory-placebo-how-can-we-better-please-the-patient
#18
P van Eijsden, Y Smulders
There is ample evidence to support the notion that the context of a treatment influences the efficacy of that treatment. Most doctors feel uncomfortable with the intentional introduction of contextual elements that have no plausible biological effect, because it is not in line with their biomechanical world view and training. Withholding certain information to prevent nocebo effects may even go against our duty to inform patients. We argue that our primary duty is to serve the interest of our patients and that to withhold positive contextual elements or to introduce negative contextual elements conflicts with this duty...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27470917/changes-in-perception-of-treatment-efficacy-are-associated-to-the-magnitude-of-the-nocebo-effect-and-to-personality-traits
#19
Nicole Corsi, Mehran Emadi Andani, Michele Tinazzi, Mirta Fiorio
The nocebo effect in motor performance consists in a reduction of force and increase of fatigue following the application of an inert treatment that the recipient believes to be effective. This effect is variable across individuals and it is usually stronger if conditioning -exposure to the active effect of the treatment- precedes a test session, in which the treatment is inert. In the current explorative study we used a conditioning procedure to investigate whether subjective perception of treatment effectiveness changes between the conditioning and the test session and whether this change is related to dispositional traits and to the nocebo-induced reduction of force...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27461877/expectation-to-feel-more-pain-disrupts-the-habituation-of-laser-pain-rating-and-laser-evoked-potential-amplitudes
#20
Costanza Pazzaglia, Elisa Testani, Rocco Giordano, Luca Padua, Massimiliano Valeriani
Increased pain perception due to the expectation to feel more pain is called nocebo effect. The present study aimed at investigating whether: (1) the mere expectation to feel more pain after the administration of an inert drug can affect the laser-pain rating and the laser-evoked potential (LEP) amplitude, and (2) the learning potentiates the nocebo effect. Eighteen healthy volunteers were told that an inert cream, applied on the right hand, would increase the laser pain and LEP amplitude to right hand stimulation...
October 1, 2016: Neuroscience
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