Qi Xu, Lihong Sun, Qing Chen, Cuicui Jiao, Yuan Wang, Hua Li, Jiaqian Xie, Fangfang Zhu, Jiangling Wang, Wen Zhang, Linghua Xie, Hui Wu, Zhiyi Zuo, Xinzhong Chen
Postpartum depression (PPD) is a severe mental disorder that affects approximately 10---20% of women after childbirth. The precise mechanism underlying PPD pathogenesis remains elusive, thus limiting the development of therapeutics. Gut microbiota dysbiosis is considered to contribute to major depressive disorder. However, the associations between gut microbiota and PPD remain unanswered. Here, we established a mouse PPD model by sudden ovarian steroid withdrawal after hormone-simulated pseudopregnancy-human (HSP-H) in ovariectomy (OVX) mouse...
April 8, 2024: Brain, Behavior, and Immunity