Antonio Lima Braga, Ag-Anne Pereira Melo de Meneses, José Victor de Oliveira Santos, Antonielly Campinho Dos Reis, Rosália Maria Tôrres de Lima, Ana Maria Oliveira Ferreira da Mata, Márcia Fernanda Correia Jardim Paz, Leane Brunelle Dos Santos Alves, Subrata Shaw, Shaikh Jamal Uddin, Razina Rouf, Asish Kumar Das, Shrabanti Dev, Manik Chandra Shil, Jamil A Shilpi, Ishaq N Khan, Muhammad Torequl Islam, Eunüs S Ali, Mohammad S Mubarak, Siddhartha Kumar Mishra, João Marcelo de Castro E Sousa, Ana Amélia de Carvalho Melo-Cavalcante
Omeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages...
April 5, 2018: Chemosphere