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Interdigitating dendritic cells sarcoma

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https://www.readbyqxmd.com/read/28695297/histiocytic-and-dendritic-cell-neoplasms-what-have-we-learnt-by-studying-67-cases
#1
Fabio Facchetti, Stefano Aldo Pileri, Luisa Lorenzi, Valentina Tabanelli, Lisa Rimsza, Stefania Pittaluga, Stephan Dirnhofer, Christiane Copie-Bergman, Laurence de Leval, Andreas Rosenwald, Andrew Wotherspoon, Falko Fend
Tumors derived from histiocytic and dendritic cells encompass a large and heterogeneous group of neoplastic and reactive conditions, and their diagnosis is challenging both for pathologists and clinicians. Diagnosis is based on morphological and phenotypical findings, but hybrid features are not uncommon. Furthermore, recent studies uncovered the molecular mechanisms driving some of these tumors, improving diagnostic adequacy, and providing the basis for effective therapeutic breakthroughs.Sixty-seven cases were submitted to the accessory cell and histiocytic neoplasms session at the European Association of Haematopathology/Society for Hematopathology workshop 2016 held in Basel, Switzerland...
July 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28643685/-disseminated-interdigitating-dendritic-cell-sarcoma
#2
Ignacio M Santarelli, Mariano Veltri, Diego J Manzella, María Alejandra Avagnina, Pablo M Pereyra, Hernán C Chavín
A 70 year-old woman was admitted to our hospital with a 3-month history of abdominal pain, weight loss and night sweats. On physical examination, she presented with a 5 cm diameter abdominal mass extended from epigastrium to the left flank, and at least three bilateral supraclavicular adenopathies. A disseminated interdigitating dendritic cell sarcoma was diagnosed through a biopsy of the abdominal mass. After that, a CHOP regime (cyclophosphamide, doxorubicin, vincristine and prednisone) was iniciated. She died after completion of the first cycle of treatment, six months after diagnosis...
2017: Medicina
https://www.readbyqxmd.com/read/28484155/interdigitating-dendritic-cell-sarcoma-successfully-treated-with-abvd-therapy-in-which-serum-cea-levels-correlated-with-disease-activity
#3
Reona Sakemura, Junji Hiraga, Satoshi Kitagawa, Masafumi Ito, Tomohiro Kajiguchi, Shinichi Mizuno
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare neoplasm of spindle to ovoid cells with phenotypic features similar to those of interdigitating dendritic cells. No standard therapy for advanced IDCS has yet been established. According to past reports, CHOP-like regimens are often chosen as primary therapy. Herein, we report a case with advanced IDCS, for which ABVD achieved remarkable clinical improvement and serial CEA levels correlated with disease status. A 76-year-old man presented with general fatigue and pancytopenia with CEA elevation...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28422825/interdigitating-dendritic-cell-sarcoma-presenting-in-the-sigmoid-colon-mesentery-a-case-report-and-literature-review
#4
REVIEW
Jianguo Zhu, Sheng Su, Jinfa Zhou, Haige Li
RATIONALE: Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare disease. It commonly occurs in middle-aged males and mainly involves the lymph nodes. Pathological examination plays an important role in differentiating from other tumors, but far less published literature focuses on the imaging characteristics of IDCS. PATIENT CONCERNS: Here, we reported a case of IDCS in a 52-year-old male involving the pelvis with medical imaging and pathologic findings...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28386111/diffuse-lesion-and-necrosis-tied-to-poorer-prognosis-of-interdigitating-dendritic-cell-sarcoma-cases-report-and-a-pooled-analysis
#5
Feng Shi, Qingkun Song, Lingling Wang, Ying Gao, Hong Chang
Interdigitating dendritic cell sarcoma is a neoplastic proliferation of interdigitating dendritic cells and no therapeutic consensus exists. This study aimed to investigate the prognostic impacts of tumor lesion, cellular atypia, mitosis and necrosis on the interdigitating dendritic cell sarcoma. Case reports and pooled analyses were designed to explore the relationships. One case was a 40-years old man with localized lesion, moderate to notable cellular atypia, 30 mitoses per 10 high-power fields and no necrosis and the progression-free survival was longer than 20 months...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302385/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-is-a-morphologic-and-phenotypic-simulator-of-poorly-differentiated-metastatic-melanoma-a-report-of-2-cases-and-review-of-the-literature
#6
REVIEW
Cynthia M Magro, Luke C Olson, Gerard Nuovo, Garron J Solomon
Interdigitating dendritic cell sarcoma (IDS) is a rare form of hematologic malignancy associated with an aggressive clinical course. Only 4 prior cases have been described as originating in the skin. We encountered two male patients ages 47 and 61years of age who presented with solitary cutaneous neoplasms diagnosed as IDS. Histologic exam showed a coalescing nested and multinodular proliferation of large pleomorphic epithelioid cells. In one case an initial diagnosis of melanoma was rendered. A recurrence 8months later was then interpreted as a primary cutaneous IDS...
February 20, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28145886/identification-of-novel-follicular-dendritic-cell-sarcoma-markers-fdcsp-and-srgn-by-whole-transcriptome-sequencing
#7
Luisa Lorenzi, Claudia Döring, Tobias Rausch, Vladimir Benes, Silvia Lonardi, Mattia Bugatti, Elias Campo, José Cabeçadas, Ingrid Simonitsch-Klupp, Anita Borges, Jay Mehta, Claudio Agostinelli, Stefano Aldo Pileri, Fabio Facchetti, Martin-Leo Hansmann, Sylvia Hartmann
Follicular dendritic cell (FDC)-sarcoma is a rare neoplasm with morphologic and phenotypic features of FDCs. It shows an extremely heterogeneous morphology, therefore, its diagnosis relys on the phenotype of tumor cells. Aim of the present study was the identification of new specific markers for FDC-sarcoma by whole transcriptome sequencing (WTS). Candidate markers were selected based on gene expression level and biological function. Immunohistochemistry was performed on reactive tonsils, on 22 cases of FDC-sarcomas and 214 control cases including 114 carcinomas, 87 soft tissue tumors, 5 melanomas, 5 thymomas and 3 interdigitating dendritic cell sarcomas...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27823979/high-frequency-of-clonal-ig-and-t-cell-receptor-gene-rearrangements-in-histiocytic-and-dendritic-cell-neoplasms
#8
Wenting Huang, Tian Qiu, Linshu Zeng, Bo Zheng, Jianming Ying, Xiaoli Feng
The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27680605/oncogene-status-of-an-interdigitating-dendritic-cell-sarcoma-recurrent-mutations-in-nf1-tp53-and-arid2-shared-with-melanoma
#9
Uwe Hillen, Florian Grabellus, Cindy Franklin, Antje Sucker, Dirk Schadendorf, Bastian Schilling
No abstract text is available yet for this article.
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27442049/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-a-case-report-and-review-of-the-literature
#10
REVIEW
Catherine M Nguyen, David Cassarino
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor of spindle to ovoid cells intermixed with lymphocytes and plasma cells. Primary cutaneous IDCS, with no nodal or other organ involvement is extremely rare, with less than 10 cases reported to date. Herein, the authors describe a case in which a 61-year-old man presented with scattered subcutaneous nodules on his left shoulder and right anterior thigh. A biopsy was performed, and the histopathologic findings revealed prominent, diffuse superficial, and deep dermal infiltration by an atypical epithelioid-shaped tumor forming sheets and cords infiltrating throughout the dermis...
August 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27299798/spindle-cell-melanoma-and-interdigitating-dendritic-cell-sarcoma-do-they-represent-the-same-process
#11
Anne M Stowman, Stacey E Mills, Mark R Wick
Intranodal spindle cell lesions on biopsy are problematic for a surgical pathologist, often requiring an extensive immunohistochemical evaluation with variable and frequently unsatisfactory results. In the absence of a history of malignancy, the differential diagnosis of a spindle cell tumor must include both a primary nodal proliferation and a metastatic process. Particularly challenging are those lesions that share morphologic and immunohistochemical features; spindle cell melanomas (SCM) and interdigitating dendritic cell sarcomas (IDCS) belong to this category...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26332157/clinicopathological-features-of-inflammatory-pseudotumour-like-follicular-dendritic-cell-tumour-of-the-abdomen
#12
Yanyang Chen, Huijuan Shi, Hui Li, Tiantian Zhen, Anjia Han
AIMS: Inflammatory pseudotumour-like follicular dendritic cell (FDC) tumour is an extremely rare neoplasm. Herein, we report 10 cases of inflammatory pseudotumour-like FDC tumours in the abdomen and analyse their clinicopathological features. METHODS AND RESULTS: Seven patients were male, and three patients were female. The patients' age ranged from 28 years to 68 years (mean age, 52.9 years; median age, 51.5 years). Grossly, the tumour was usually solitary, well circumscribed, and solid, ranging from 23 mm to 233 mm in greatest diameter...
May 2016: Histopathology
https://www.readbyqxmd.com/read/26305140/-tumors-of-dendritic-and-other-accessory-cells-of-lymph-nodes
#13
REVIEW
Alexandar Tzankov, Stephan Dirnhofer
Besides the obviously much more common lymphomas, neoplasms of dendritic and other so-called accessory cells can also primarily originate in lymph nodes. These include histiocytic sarcomas, follicular dendritic cell sarcomas, interdigitating dendritic cell sarcomas, fibroblastic reticulum cell tumors/cytokeratin-positive interstitial cell neoplasms and neoplasms of indeterminate dendritic cells. A feature common to all of these tumors is the very difficult differential diagnosis, not least because of their rarity; however, a careful analysis will allow discrimination from other sarcomas, sarcomatoid carcinomas, lymphomas and melanomas and lead to the correct classification of the respective lesions...
September 2015: Der Pathologe
https://www.readbyqxmd.com/read/26298731/impact-of-surgery-radiation-and-systemic-therapy-on-the-outcomes-of-patients-with-dendritic-cell-and-histiocytic-sarcomas
#14
Mrinal Gounder, Ved Desai, Deborah Kuk, Narasimhan Agaram, Maria Arcila, Benjamin Durham, Mary L Keohan, Mark A Dickson, Sandra P D'Angelo, Neerav Shukla, Craig Moskowitz, Ariela Noy, Robert G Maki, Diego Adrianzen Herrera, Armando Sanchez, Anita Krishnan, Andrew Pourmoussa, Li-Xuan Qin, William D Tap
BACKGROUND: Neoplasms of histiocytic and dendritic cell origin, including follicular dendritic cell sarcoma (FDCS), histiocytic sarcoma (HS) and interdigitating dendritic cell sarcoma (IDCS), are extremely rare, and data on their natural history and treatment outcomes are sparse. We evaluated the impact of surgery, radiation and systemic therapies on overall survival (OS). METHODS: We conducted a retrospective chart review of patients with FDCS, IDCS and HS treated at Memorial Sloan Kettering Cancer Center between 1995 and 2014...
November 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/26237342/intracranial-interdigitating-dendritic-cell-sarcoma-first-case-report
#15
Gregor Hutter, Silvia Hofer, Alexandar Tzankov, Karl F Kothbauer
BACKGROUND AND IMPORTANCE: This is the first report of a primarily intracranial interdigitating dendritic cell sarcoma (IDCS). CLINICAL PRESENTATION: A 39-year-old patient with right hemiparesis underwent complete resection of a large parafalcine tumor with subsequent complete recovery of neurological symptoms. Histologically, the tumor was diagnosed as IDCS. Extensive staging did not reveal any extracranial manifestation of this disease. After 1.5 years, the patient remains recurrence free and is being observed closely...
December 2015: Neurosurgery
https://www.readbyqxmd.com/read/26199576/sustained-remission-after-abvd-treatment-for-interdigitating-dendritic-cell-sarcoma
#16
Grzegorz Helbig, Ryszard Wichary, Jacek Pająk, Maria Budny, Małgorzata Makowska, Klaudyna Machura, Marcin Kubeczko, Sławomira Kyrcz-Krzemień
No abstract text is available yet for this article.
2015: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/26106005/complete-remission-in-systemic-skin-interdigitating-dendritic-cell-sarcoma-after-abvd-chemotherapy
#17
Chieko Kyogoku, Masanori Seki, Shinichi Ogawa, Kana Miyamoto, Yufu Ito, Naoki Kurita, Yasuhisa Yokoyama, Mamiko Sakata-Yanagimoto, Naoshi Obara, Yuichi Hasegawa, Fumiyoshi Fujishima, Ryo Ichinohasama, Shigeo Nakamura, Shigeru Chiba
Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein...
2015: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/26071439/spontaneous-regression-of-interdigitating-dendritic-sarcoma-in-a-patient-with-concurrent-small-lymphocytic-lymphoma
#18
Tamer Khashab, Lalit Sehgal, L Jeffrey Medeiros, Felipe Samaniego
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumour; only seven cases of IDCS associated with chronic lymphocytic leucaemia/small lymphocytic lymphoma (CLL/SLL) have been reported. We present the case of a 60-year-old man who presented with fevers, night sweats and significant unintentional weight loss. Investigations led to a diagnosis of synchronous SLL and IDCS. Subsequent fluorodeoxyglucose (FDG) positron emission tomography CT (PET-CT) imaging revealed an unusual clinical course with spontaneously resolving highly metabolic lesions...
June 12, 2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26047060/braf-mutation-in-interdigitating-dendritic-cell-sarcoma-a-case-report-and-review-of-the-literature
#19
REVIEW
Elisabetta Di Liso, Natale Pennelli, Gigliola Lodovichetti, Cristina Ghiotto, Angelo Paolo Dei Tos, PierFranco Conte, Laura Bonanno
Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and different chemotherapy combinations have been tested for advanced disease. No evidence from prospective trials is currently available. We report the case of a 59 year-old male patient who experienced axillary lymphadenopathy with initial diagnosis of large-cell lung cancer on tumor biopsy...
2015: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/25787243/evidence-of-braf-v600e-in-indeterminate-cell-tumor-and-interdigitating-dendritic-cell-sarcoma
#20
Dennis P O'Malley, Renuka Agrawal, Kate E Grimm, Jennifer Hummel, Alexey Glazyrin, Daniel C Dim, Sheshadri Madhusudhana, Lawrence M Weiss
BRAF V600E mutations have been reported in several histiocytic and dendritic cell neoplasms. In this case series, we report BRAF V600E-positive histiocytic and dendritic cell neoplasms in association with lymphomas and lymphoid proliferations. This is a review of cases with immunohistochemistry for BRAF V600E, with additional immunohistochemistry to categorize tumors. We report the first case of BRAF V600E-positive indeterminate cell tumor in association with angioimmunoblastic T-cell lymphoma. We also report a case of BRAF V600E-positive interdigitating dendritic cell sarcoma in a patient with positive B-cell polymerase chain reaction...
June 2015: Annals of Diagnostic Pathology
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