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Interdigitating dendritic cells sarcoma

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https://www.readbyqxmd.com/read/27823979/high-frequency-of-clonal-ig-and-t-cell-receptor-gene-rearrangements-in-histiocytic-and-dendritic-cell-neoplasms
#1
Wenting Huang, Tian Qiu, Linshu Zeng, Bo Zheng, Jianming Ying, Xiaoli Feng
The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27680605/oncogene-status-of-an-interdigitating-dendritic-cell-sarcoma-recurrent-mutations-in-nf1-tp53-and-arid2-shared-with-melanoma
#2
Uwe Hillen, Florian Grabellus, Cindy Franklin, Antje Sucker, Dirk Schadendorf, Bastian Schilling
No abstract text is available yet for this article.
September 27, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27442049/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-a-case-report-and-review-of-the-literature
#3
Catherine M Nguyen, David Cassarino
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumor of spindle to ovoid cells intermixed with lymphocytes and plasma cells. Primary cutaneous IDCS, with no nodal or other organ involvement is extremely rare, with less than 10 cases reported to date. Herein, the authors describe a case in which a 61-year-old man presented with scattered subcutaneous nodules on his left shoulder and right anterior thigh. A biopsy was performed, and the histopathologic findings revealed prominent, diffuse superficial, and deep dermal infiltration by an atypical epithelioid-shaped tumor forming sheets and cords infiltrating throughout the dermis...
August 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27299798/spindle-cell-melanoma-and-interdigitating-dendritic-cell-sarcoma-do-they-represent-the-same-process
#4
Anne M Stowman, Stacey E Mills, Mark R Wick
Intranodal spindle cell lesions on biopsy are problematic for a surgical pathologist, often requiring an extensive immunohistochemical evaluation with variable and frequently unsatisfactory results. In the absence of a history of malignancy, the differential diagnosis of a spindle cell tumor must include both a primary nodal proliferation and a metastatic process. Particularly challenging are those lesions that share morphologic and immunohistochemical features; spindle cell melanomas (SCM) and interdigitating dendritic cell sarcomas (IDCS) belong to this category...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26332157/clinicopathological-features-of-inflammatory-pseudotumour-like-follicular-dendritic-cell-tumour-of-the-abdomen
#5
Yanyang Chen, Huijuan Shi, Hui Li, Tiantian Zhen, Anjia Han
AIMS: Inflammatory pseudotumour-like follicular dendritic cell (FDC) tumour is an extremely rare neoplasm. Herein, we report 10 cases of inflammatory pseudotumour-like FDC tumours in the abdomen and analyse their clinicopathological features. METHODS AND RESULTS: Seven patients were male, and three patients were female. The patients' age ranged from 28 years to 68 years (mean age, 52.9 years; median age, 51.5 years). Grossly, the tumour was usually solitary, well circumscribed, and solid, ranging from 23 mm to 233 mm in greatest diameter...
May 2016: Histopathology
https://www.readbyqxmd.com/read/26305140/-tumors-of-dendritic-and-other-accessory-cells-of-lymph-nodes
#6
REVIEW
Alexandar Tzankov, Stephan Dirnhofer
Besides the obviously much more common lymphomas, neoplasms of dendritic and other so-called accessory cells can also primarily originate in lymph nodes. These include histiocytic sarcomas, follicular dendritic cell sarcomas, interdigitating dendritic cell sarcomas, fibroblastic reticulum cell tumors/cytokeratin-positive interstitial cell neoplasms and neoplasms of indeterminate dendritic cells. A feature common to all of these tumors is the very difficult differential diagnosis, not least because of their rarity; however, a careful analysis will allow discrimination from other sarcomas, sarcomatoid carcinomas, lymphomas and melanomas and lead to the correct classification of the respective lesions...
September 2015: Der Pathologe
https://www.readbyqxmd.com/read/26298731/impact-of-surgery-radiation-and-systemic-therapy-on-the-outcomes-of-patients-with-dendritic-cell-and-histiocytic-sarcomas
#7
Mrinal Gounder, Ved Desai, Deborah Kuk, Narasimhan Agaram, Maria Arcila, Benjamin Durham, Mary L Keohan, Mark A Dickson, Sandra P D'Angelo, Neerav Shukla, Craig Moskowitz, Ariela Noy, Robert G Maki, Diego Adrianzen Herrera, Armando Sanchez, Anita Krishnan, Andrew Pourmoussa, Li-Xuan Qin, William D Tap
BACKGROUND: Neoplasms of histiocytic and dendritic cell origin, including follicular dendritic cell sarcoma (FDCS), histiocytic sarcoma (HS) and interdigitating dendritic cell sarcoma (IDCS), are extremely rare, and data on their natural history and treatment outcomes are sparse. We evaluated the impact of surgery, radiation and systemic therapies on overall survival (OS). METHODS: We conducted a retrospective chart review of patients with FDCS, IDCS and HS treated at Memorial Sloan Kettering Cancer Center between 1995 and 2014...
November 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/26237342/intracranial-interdigitating-dendritic-cell-sarcoma-first-case-report
#8
Gregor Hutter, Silvia Hofer, Alexandar Tzankov, Karl F Kothbauer
BACKGROUND AND IMPORTANCE: This is the first report of a primarily intracranial interdigitating dendritic cell sarcoma (IDCS). CLINICAL PRESENTATION: A 39-year-old patient with right hemiparesis underwent complete resection of a large parafalcine tumor with subsequent complete recovery of neurological symptoms. Histologically, the tumor was diagnosed as IDCS. Extensive staging did not reveal any extracranial manifestation of this disease. After 1.5 years, the patient remains recurrence free and is being observed closely...
December 2015: Neurosurgery
https://www.readbyqxmd.com/read/26199576/sustained-remission-after-abvd-treatment-for-interdigitating-dendritic-cell-sarcoma
#9
Grzegorz Helbig, Ryszard Wichary, Jacek Pająk, Maria Budny, Małgorzata Makowska, Klaudyna Machura, Marcin Kubeczko, Sławomira Kyrcz-Krzemień
No abstract text is available yet for this article.
2015: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/26106005/complete-remission-in-systemic-skin-interdigitating-dendritic-cell-sarcoma-after-abvd-chemotherapy
#10
Chieko Kyogoku, Masanori Seki, Shinichi Ogawa, Kana Miyamoto, Yufu Ito, Naoki Kurita, Yasuhisa Yokoyama, Mamiko Sakata-Yanagimoto, Naoshi Obara, Yuichi Hasegawa, Fumiyoshi Fujishima, Ryo Ichinohasama, Shigeo Nakamura, Shigeru Chiba
Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein...
2015: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/26071439/spontaneous-regression-of-interdigitating-dendritic-sarcoma-in-a-patient-with-concurrent-small-lymphocytic-lymphoma
#11
Tamer Khashab, Lalit Sehgal, L Jeffrey Medeiros, Felipe Samaniego
Interdigitating dendritic cell sarcoma (IDCS) is a rare tumour; only seven cases of IDCS associated with chronic lymphocytic leucaemia/small lymphocytic lymphoma (CLL/SLL) have been reported. We present the case of a 60-year-old man who presented with fevers, night sweats and significant unintentional weight loss. Investigations led to a diagnosis of synchronous SLL and IDCS. Subsequent fluorodeoxyglucose (FDG) positron emission tomography CT (PET-CT) imaging revealed an unusual clinical course with spontaneously resolving highly metabolic lesions...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26047060/braf-mutation-in-interdigitating-dendritic-cell-sarcoma-a-case-report-and-review-of-the-literature
#12
REVIEW
Elisabetta Di Liso, Natale Pennelli, Gigliola Lodovichetti, Cristina Ghiotto, Angelo Paolo Dei Tos, PierFranco Conte, Laura Bonanno
Interdigitating dendritic cell sarcoma is an extremely rare tumor. The diagnosis is difficult and is based on clinical, pathological and immunohistochemical evaluation. Differential diagnosis includes melanoma, mesenchymal and hematological malignancies. The mainstay of treatment is surgery for limited disease and different chemotherapy combinations have been tested for advanced disease. No evidence from prospective trials is currently available. We report the case of a 59 year-old male patient who experienced axillary lymphadenopathy with initial diagnosis of large-cell lung cancer on tumor biopsy...
2015: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/25787243/evidence-of-braf-v600e-in-indeterminate-cell-tumor-and-interdigitating-dendritic-cell-sarcoma
#13
Dennis P O'Malley, Renuka Agrawal, Kate E Grimm, Jennifer Hummel, Alexey Glazyrin, Daniel C Dim, Sheshadri Madhusudhana, Lawrence M Weiss
BRAF V600E mutations have been reported in several histiocytic and dendritic cell neoplasms. In this case series, we report BRAF V600E-positive histiocytic and dendritic cell neoplasms in association with lymphomas and lymphoid proliferations. This is a review of cases with immunohistochemistry for BRAF V600E, with additional immunohistochemistry to categorize tumors. We report the first case of BRAF V600E-positive indeterminate cell tumor in association with angioimmunoblastic T-cell lymphoma. We also report a case of BRAF V600E-positive interdigitating dendritic cell sarcoma in a patient with positive B-cell polymerase chain reaction...
June 2015: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/25722315/challenges-in-the-differential-diagnosis-of-interdigitating-dendritic-cell-sarcoma-of-intraparotid-lymph-node-vs-metastatic-malignant-melanoma-with-unknown-primary-site
#14
Fernando Galli, Viktorija Petraitiene, Senthil Kumar Muthu, Sophie James, Venkata Rao Koppana, Arvind Arya
Interdigitating dendritic cell sarcoma (IDCS) is an uncommon form of malignant histiocytosis affecting dendritic cells. The parotid gland more frequently than other salivary glands has metastasis from extraparotid tumours, which in 80% of cases are melanomas and squamous cell carcinomas. Herein we report our case, a 64-year-old woman who presented with a short history of fluctuating in size swelling below her right ear. Ultrasound scan showed a loculated cystic lesion extending in the parotid parenchyma. Fine needle aspiration (FNA) revealed appearances that were highly suspicious of malignancy, therefore MRI scan was arranged, and parotidectomy planned...
May 2015: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/25691604/interdigitating-dendritic-cell-sarcoma
#15
REVIEW
Venkata K Pokuri, Mihai Merzianu, Shipra Gandhi, Junaid Baqai, Thom R Loree, Seema Bhat
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare dendritic cell tumor with slightly more than 100 cases reported in the English literature. This report discusses a case of localized IDCS involving cervical lymph nodes and provides a literature review of clinicopathologic aspects and treatment outcomes.
February 2015: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/25568750/interdigitating-dendritic-cell-sarcoma-presenting-in-the-skin-diagnosis-and-the-role-of-surgical-resection-chemotherapy-and-radiotherapy-in-management
#16
Stephen A Rosenberg, Scot A Niglio, Vickie Y Jo, James S Goydos
We report the case of an interdigitating dendritic cell sarcoma (IDCS) presenting in the skin. A 41-year old woman had a slowly enlarging mass on her right scapula that was excised multiple times under a presumptive diagnosis of a recurrent sebaceous cyst. However, the lesion was refractory to standard therapies. History and physical exam was unrevealing for any systemic signs or symptoms of disease. The patient's metastatic work-up was negative. The lesion was resected with wide margins and was found to be consistent with IDCS...
October 27, 2014: Rare Tumors
https://www.readbyqxmd.com/read/25405526/clinicopathologic-characteristics-and-outcomes-of-histiocytic-and-dendritic-cell-neoplasms-the-moffitt-cancer-center-experience-over-the-last-twenty-five-years
#17
Samir Dalia, Michael Jaglal, Paul Chervenick, Hernani Cualing, Lubomir Sokol
Neoplasms of histiocytic and dendritic cells are rare disorders of the lymph node and soft tissues. Because of this rarity, the corresponding biology, prognosis and terminologies are still being better defined and hence historically, these disorders pose clinical and diagnostic challenges. These disorders include Langerhans cell histiocytosis (LCH), histiocytic sarcoma (HS), follicular dendritic cell sarcoma (FDCS), interdigtating cell sarcoma (IDCS), indeterminate cell sarcoma (INDCS), and fibroblastic reticular cell tumors (FRCT)...
2014: Cancers
https://www.readbyqxmd.com/read/25321088/primary-cutaneous-interdigitating-dendritic-cell-sarcoma-a-case-report-and-review-of-the-literature
#18
REVIEW
Shi-Jun Shan, Ling-He Meng, Rebecca Lu, Ying Guo
Interdigitating dendritic cell sarcoma (IDCS) is defined as a neoplastic proliferation of spindle to ovoid cells with phenotypic features similar to those of interdigitating dendritic cells, which are present in the T cell-rich areas of lymphoid organs and participate as antigen-presenting cells responsible for initiating primary T lymphocyte immune response. IDCS usually presents with lymphadenopathy. Solitary lymph node involvement is often seen. Extra nodal presentation has been described as well. Cutaneous lesions are extremely rare, and less than 10 cases have been previously documented in medical literature...
August 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/25310210/dendritic-cell-and-histiocytic-neoplasms-biology-diagnosis-and-treatment
#19
REVIEW
Samir Dalia, Haipeng Shao, Elizabeth Sagatys, Hernani Cualing, Lubomir Sokol
BACKGROUND: Dendritic and histiocytic cell neoplasms are rare malignancies that make up less than 1% of all neoplasms arising in lymph nodes or soft tissues. These disorders have distinctive disease biology, clinical presentations, pathology, and unique treatment options. Morphology and immunohistochemistry evaluation by a hematopathologist remains key for differentiating between these neoplasms. In this review, we describe tumor biology, clinical features, pathology, and treatment of follicular dendritic cell sarcoma, interdigitating dendritic cell sarcoma, indeterminate dendritic cell sarcoma, histiocytic sarcoma, fibroblastic reticular cell tumors, and disseminated juvenile xanthogranuloma...
October 2014: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/24742569/-interdigitating-dendritic-cell-sarcoma-tumor-a-clinicopathologic-study
#20
Minhong Pan, Qixing Gong, Qinhe Fan, Zhihong Zhang, Yang Li, Cong Wang
OBJECTIVE: To study the clinicopathologic characteristics and diagnostic criteria of interdigitating dendritic cell sarcoma/tumor (IDCS/T). METHODS: The clinical features, histologic findings and results of immunohistochemical study in six cases of IDCS/T were analyzed, with review of literature. RESULTS: The age of patients ranged from 20 to 68 years. The sites of involvement included lymph node, tonsil and soft tissue. Histologically, the tumor cells were arranged in sheets, fascicles or whorls and intimately admixed with abundant lymphocytes and plasma cells...
February 2014: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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