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DNA nanotechnology

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https://www.readbyqxmd.com/read/28094775/nanotechnologies-in-delivery-of-mrna-therapeutics-using-nonviral-vector-based-delivery-systems
#1
REVIEW
S Guan, J Rosenecker
Due to its safe and effective protein expression profile, in vitro transcribed messenger RNA (IVT-mRNA) represents a promising candidate in the development of novel therapeutics for genetic diseases, vaccines or gene editing strategies, especially when its inherent shortcomings (e.g. instability and immunogenicity) have been partially addressed via structural modifications. However, numerous unsolved technical difficulties in successful in vivo delivery of IVT-mRNA have greatly hindered the applications of IVT-mRNA in clinical development...
January 17, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28094516/designed-dna-crystal-habit-modifiers
#2
Diana Zhang, Paul J Paukstelis
DNA is now one of the most widely used molecules for programmed self-assembly of discrete nanostructures. One of the long-standing goals of the DNA nanotechnology field has been the assembly of periodic, macroscopic 3D DNA crystals for controlled positioning of guest molecules to be used in a variety of applications. With continuing successes in assembling DNA crystals there is an enhanced need to tailor macroscopic crystal properties - including morphology - to enable their integration into more complex systems...
January 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28092742/short-term-in-vivo-exposure-to-graphene-oxide-can-cause-damage-to-the-gut-and-testis
#3
Marta Dziewięcka, Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
Graphene oxide (GO) has unique physicochemical properties and also has a potentially widespread use in every field of daily life (industry, science, medicine). Demand for nanotechnology is growing every year, and therefore many aspects of its toxicity and biocompatibility still require further clarification. This research assesses the in vivo toxicity of pure and manganese ion-contaminated GO that were administrated to Acheta domesticus with food (at 200mgkg(-1) of food) throughout their ten-day adult life...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28074960/search-for-effective-chemical-quenching-to-arrest-molecular-assembly-and-directly-monitor-dna-nanostructure-formation
#4
J M Majikes, J A Nash, T H LaBean
Structural DNA nanotechnology has demonstrated both versatility and potential as a molecular manufacturing tool; the formation and processing of DNA nanostructures has therefore been subject to much interest. Characterization of the formation process itself is vital to understanding the role of design in production yield. We present our search for a robust new technique, chemical quenching, to arrest molecular folding in DNA systems for subsequent characterization. Toward this end we will introduce two miniM13 origami designs based on a 2...
January 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28070131/dna-nanotechnology-a-nucleosome-clamp
#5
Chiara Pastore
No abstract text is available yet for this article.
January 10, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28064006/versatile-rna-tetra-u-helix-linking-motif-as-a-toolkit-for-nucleic-acid-nanotechnology
#6
My N Bui, M Brittany Johnson, Mathias Viard, Emily Satterwhite, Angelica N Martins, Zhihai Li, Ian Marriott, Kirill A Afonin, Emil F Khisamutdinov
RNA nanotechnology employs synthetically modified ribonucleic acid (RNA) to engineer highly stable nanostructures in one, two, and three dimensions for medical applications. Despite the tremendous advantages in RNA nanotechnology, unmodified RNA itself is fragile and prone to enzymatic degradation. In contrast to use traditionally modified RNA strands e.g. 2'-fluorine, 2'-amine, 2'-methyl, we studied the effect of RNA/DNA hybrid approach utilizing a computer-assisted de novo RNA tetra-uracil (tetra-U) motif as a toolkit to address questions related to assembly efficiency, versatility, stability, and the production costs of hybrid RNA/DNA nanoparticles...
January 4, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28048935/engineered-diblock-polypeptides-improve-dna-and-gold-solubility-during-molecular-assembly
#7
Nicole A Estrich, Armando Hernandez-Garcia, Renko de Vries, Thomas H LaBean
Programmed molecular recognition is being developed for the bionanofabrication of mixed organic/inorganic supramolecular assemblies for applications in electronics, photonics, and medicine. For example, DNA-based nanotechnology seeks to exploit the easily programmed complementary base-pairing of DNA to direct assembly of complex, designed nanostructures. Optimal solution conditions for bionanofabrication, mimicking those of biological systems, may involve high concentrations of biomacromolecules (proteins, nucleic acids, etc...
January 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28033500/autonomous-assembly-of-ordered-metastable-dna-nanoarchitecture-and-in-situ-visualizing-of-intracellular-micrornas
#8
Jianguo Xu, Zai-Sheng Wu, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia
Facile assembly of intelligent DNA nanoobjects with the ability to exert in situ visualization of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA nanotechnology and basic medical study. Here, we present a driving primer (DP)-triggered polymerization-mediated metastable assembly (PMA) strategy to prepare a well-ordered metastable DNA nanoarchitecture composed of only two hairpin probes (HAPs), which has never been explored by assembly methods. Its structural features and functions are characterized by atomic force microscope (AFM) and gel electrophoresis...
December 22, 2016: Biomaterials
https://www.readbyqxmd.com/read/28031943/supramolecular-polymer-formation-by-cyclic-dinucleotides-and-intercalators-affects-dinucleotide-enzymatic-processing
#9
Shizuka Nakayama, Jie Zhou, Yue Zheng, Henryk Szmacinski, Herman O Sintim
BACKGROUND: Cyclic dinucleotides form supramolecular aggregates with intercalators, and this property could be utilized in nanotechnology and medicine. METHODS & RESULTS: Atomic force microscopy and electrophoretic mobility shift assays were used to show that cyclic diguanylic acid (c-di-GMP) forms G-wires in the presence of intercalators. The average fluorescence lifetime of thiazole orange, when bound to c-di-GMP was greater than when bound to DNA G-quadruplexes or dsDNA...
March 2016: Future Science OA
https://www.readbyqxmd.com/read/28001403/ferrofluids-of-thermotropic-liquid-crystals-by-dna-lipid-hybrids
#10
Lu Xu, Mengjun Chen, Jingcheng Hao
Here is the first report the creation of ferrofluids of thermotropic liquid crystals in the absence of any solvent or nanoparticle. These ferrofluids were prepared by the electrostatic coupling of single-strand (ss) DNA with paramagnetic lipids. DNA molecules, as rigid parts, offer the orientational anisotropy and lipids (surfactants) due to the flexible hydrocarbon chains suppress crystallization, hybrids with DNA significantly increase the Cure temperature (Tc) of the lipids. The ferrofluids possess good fluidity and low viscosity...
January 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28000981/pd-mediated-labeling-of-nucleic-acids
#11
Samir Messaoudi, Eric Defrancq
New applications of Pd-catalyzed coupling reactions for post-conjugation of nucleic acids have been developed recently. Breakthroughs in this area might now pave the way for the development of sophisticated DNA-probes, which can find a great interest in chemical biology, nanotechnology, bioanalysis as well as diagnostic domains.
December 21, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27990812/nonlinear-kinetic-behavior-in-constitutional-dynamic-reaction-networks
#12
Joseph J Armao, Jean-Marie Lehn
Creating synthetic chemical systems which emulate the complexity observed in cells relies on exploiting chemical networks exhibiting nonlinear kinetic behavior. While control over reaction complexity using synthetic gene regulatory networks and DNA nanotechnology has developed greatly, little control exists over small molecule reaction networks. Toward this goal, we demonstrate a general framework for inducing nonlinear kinetic behavior in dynamic chemical networks based on molecules containing reversible chemical bonds...
December 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27943567/methyltransferase-directed-labeling-of-biomolecules-and-its-applications
#13
Jochem Deen, Charlotte Vranken, Volker Leen, Robert K Neely, Kris Pieter Frans Janssen, Johan Hofkens
Methyltransferases (MTases) compose a large family of enzymes which have the ability to methylate a diverse set of targets, ranging from the three major biopolymers DNA, RNA and protein to small molecules. Most of these MTases use the cofactor S-Adenosyl-L-Methionine (AdoMet) as their methyl source. Given the important biological role of methylation, e.g. in epigenetic regulation of gene activity and the vast potential of targeted functionalization in biology, diagnostics and nanotechnology, it should come as no surprise that recent years have seen significant efforts in the development of AdoMet analogues with the aim of transferring moieties other than simple methyl groups...
December 12, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27936577/precise-coating-of-a-wide-range-of-dna-templates-by-a-protein-polymer-with-a-dna-binding-domain
#14
Armando Hernandez-Garcia, Nicole A Estrich, Marc W T Werten, Johan R C Van Der Maarel, Thomas H LaBean, Frits A de Wolf, Martien A Cohen Stuart, Renko de Vries
Emerging DNA-based nanotechnologies would benefit from the ability to modulate the properties (e.g., solubility, melting temperature, chemical stability) of diverse DNA templates (single molecules or origami nanostructures) through controlled, self-assembling coatings. We here introduce a DNA coating agent, called C8-B(Sso7d), which binds to and coats with high specificity and affinity, individual DNA molecules as well as folded origami nanostructures. C8-B(Sso7d) coats and protects without condensing, collapsing or destroying the spatial structure of the underlying DNA template...
December 12, 2016: ACS Nano
https://www.readbyqxmd.com/read/27934012/synthesis-of-phosphorodiamidate-morpholino-oligonucleotides-and-their-chimeras-using-phosphoramidite-chemistry
#15
Sibasish Paul, Marvin H Caruthers
Phosphorodiamidate morpholinos (PMOs) and PMO-DNA chimeras have been prepared on DNA synthesizers using phosphoramidite chemistry. This was possible by first generating boranephosphoroamidate morpholino internucleotide linkages followed by oxidative substitution with four different amines: N,N-dimethylamine, N-methylamine, ammonia, and morpholine. When compared to a natural DNA duplex, the amino modified PMO was found to have a higher melting temperature with either complementary DNA or RNA, whereas the remaining PMO analogues having morpholino, dimethylamino, or N-methylamino phosphorodiamidate linkages had melting temperatures that were either comparable or reduced...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27925592/enzyme-free-scalable-dna-digital-design-techniques-a-review
#16
Aby K George, Harpreet Singh
With the recent developments in DNA nanotechnology, DNA has been used as the basic building block for the design of nanostructures, autonomous molecular motors, various devices, and circuits. DNA is considered as a possible candidate for replacing silicon for designing digital circuits in a near future, especially in implantable medical devices, because of its parallelism, computational powers, small size, light weight, and compatibility with bio-signals. The research in DNA digital design is in early stages of development, and electrical and computer engineers are not much attracted towards this field...
December 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27913190/synthesis-and-label-free-characterization-of-a-bimolecular-pna-homo-quadruplex
#17
Brunella Pinto, Giulia Rusciano, Stefano D'Errico, Nicola Borbone, Antonio Sasso, Vincenzo Piccialli, Luciano Mayol, Giorgia Oliviero, Gennaro Piccialli
BACKGROUND: G-quadruplex DNA is involved in many physiological and pathological processes. Both clinical and experimental studies on DNA G-quadruplexes are slowed down by their enzymatic instability. In this frame, more stable chemically modified analogs are needed. METHODS: The bis-end-linked-(gggt)2 PNA molecule (BEL-PNA) was synthesized using in solution and solid phase synthetic approaches. Quadruplex formation was assessed by circular dichroism (CD) and surface enhanced Raman scattering (SERS)...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27886299/dna-nanotechnology-for-nucleic-acid-analysis-multifunctional-molecular-dna-machine-for-rna-detection
#18
A J Cox, H N Bengtson, K H Rohde, D M Kolpashchikov
The Nobel prize in chemistry in 2016 was awarded for 'the design and synthesis of molecular machines'. Here we designed and assembled a molecular machine for the detection of specific RNA molecules. An association of several DNA strands, named multifunctional DNA machine for RNA analysis (MDMR1), was designed to (i) unwind RNA with the help of RNA-binding arms, (ii) selectively recognize a targeted RNA fragment, (iii) attract a signal-producing substrate and (iv) amplify the fluorescent signal by catalysis...
December 6, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27878179/when-biomolecules-meet-graphene-from-molecular-level-interactions-to-material-design-and-applications
#19
REVIEW
Dapeng Li, Wensi Zhang, Xiaoqing Yu, Zhenping Wang, Zhiqiang Su, Gang Wei
Graphene-based materials have attracted increasing attention due to their atomically-thick two-dimensional structures, high conductivity, excellent mechanical properties, and large specific surface areas. The combination of biomolecules with graphene-based materials offers a promising method to fabricate novel graphene-biomolecule hybrid nanomaterials with unique functions in biology, medicine, nanotechnology, and materials science. In this review, we focus on a summarization of the recent studies in functionalizing graphene-based materials using different biomolecules, such as DNA, peptides, proteins, enzymes, carbohydrates, and viruses...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27875979/self-assembled-nucleic-acid-nanostructures-for-cancer-theranostic-medicines
#20
Jinglin Fu, Gabriele Stankeviciute, Sung Won Oh, John Collins, Yinghui Zhong, Ting Zhang
Theranostic medicine has become more promising in cancer treatment, where the cancer diagnosis and chemotherapy are combined for early diagnosis and precise treatment with improved efficacy and reduced side effects. Nanotechnology has played a critical role in developing various nanomaterials with engendered smart functions and targeted delivery. The rapid development of structural DNA nanotechnology has enabled the design and fabrication of complex nanostructures with prescribed 1D, 2D and 3D patterns in vitro and in vivo...
November 22, 2016: Current Topics in Medicinal Chemistry
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