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https://www.readbyqxmd.com/read/28646798/social-context-matters-ethnicity-discrimination-and-stress-reactivity
#1
David Busse, Ilona S Yim, Belinda Campos
Exposure to chronic discrimination is associated with increased morbidity and mortality. The study of biobehavioral pathways linking discrimination with health outcomes has mostly focused on the cardiovascular system, with fewer studies addressing the hypothalamus-pituitary-adrenal (HPA) axis. In this study we tested associations between Latino ethnicity, experiences of discrimination, and cortisol responses to an acute laboratory stressor. One hundred fifty eight individuals (92 female, 66 male) between the ages of 18 and 29 years participated in the study...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28646716/histopathologic-differences-partially-distinguish-syndromic-aortic-diseases
#2
Kevin M Waters, Lisa M Rooper, Andrew Guajardo, Marc K Halushka
A variety of syndromic diseases such as Marfan syndrome, Loeys-Dietz syndrome, and bicuspid aortic valve with aneurysm along with risk factors of smoking and hypertension result in ascending aortic aneurysms and dissections. Historically, a complicated variety of terms have been used to describe a range of histopathologies that are present in resected specimens. As a result, no consistent patterns of histopathology have been reported. We used the recent Society for Cardiovascular Pathology/Association for European Cardiovascular Pathology consensus statement on nomenclature and diagnostic criteria for noninflammatory aortic disease to blindly evaluate 148 surgically resected specimens...
June 15, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28644794/electrocardiogram-signal-quality-assessment-based-on-structural-image-similarity-metric
#3
Yalda Shahriari, Richard Fidler, Michele Pelter, Yong Bai, Andrea Villaroman, Xiao Hu
OBJECTIVE: We developed an image-based electrocardiographic (ECG) quality assessment technique that mimics how clinicians annotate ECG signal quality. METHODS: We adopted the Structural Similarity Measure (SSIM) to compare images of two ECG records that are obtained from displaying ECGs in a standard scale. Then a subset of representative ECG images from the training set was selected as templates through a clustering method. SSIM between each image and all the templates were used as the feature vector for the linear discriminant analysis (LDA) classifier...
June 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28644092/single-and-multiple-cardiovascular-biomarkers-in-subjects-without-a-previous-cardiovascular-event
#4
Manan Pareek, Deepak L Bhatt, Muthiah Vaduganathan, Tor Biering-Sørensen, Arman Qamar, Axel Cp Diederichsen, Jacob Eifer Møller, Peter Hindersson, Margrét Leósdóttir, Martin Magnusson, Peter M Nilsson, Michael H Olsen
Aims To assess the incremental value of biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), growth differentiation factor 15 (GDF-15), and procollagen type 1 N-terminal propeptide (P1NP), in predicting incident cardiovascular events and mortality among asymptomatic individuals from the general population, beyond traditional risk factors, including fasting glucose and renal function (cystatin C), medication use, and echocardiographic measures...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28630342/autoantibody-profiling-on-a-plasmonic-nano-gold-chip-for-the-early-detection-of-hypertensive-heart-disease
#5
Xiaoyang Li, Tatiana Kuznetsova, Nicholas Cauwenberghs, Matthew Wheeler, Holden Maecker, Joseph C Wu, Francois Haddad, Hongjie Dai
The role of autoimmunity in cardiovascular (CV) diseases has been increasingly recognized. Autoimmunity is most commonly examined by the levels of circulating autoantibodies in clinical practices. Measurement of autoantibodies remains, however, challenging because of the deficiency of reproducible, sensitive, and standardized assays. The lack of multiplexed assays also limits the potential to identify a CV-specific autoantibody profile. To overcome these challenges, we developed a nanotechnology-based plasmonic gold chip for autoantibody profiling...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629574/biventricular-mechanics-in-prediction-of-severe-myocardial-fibrosis-in-patients-with-dilated-cardiomyopathy-cmr-study
#6
Łukasz Mazurkiewicz, Joanna Petryka, Mateusz Spiewak, Barbara Miłosz-Wieczorek, Konrad Werys, Łukasz A Małek, Magdalena Polanska-Skrzypczyk, Natalia Ojrzynska, Agata Kubik, Magdalena Marczak, Jolanta Misko, Jacek Grzybowski
PURPOSE: The purpose of this study was to compare the ability of various parameters of myocardial mechanics to predict large amounts of biventricular fibrosis assessed via T1 mapping in patients with dilated cardiomyopathy (DCM). MATERIAL: Cardiovascular magnetic resonance feature tracking analysis and T1 mapping were performed in 26 patients with DCM [mean age: 34.4±9.1years, 15 (57.6%) males]. The values of various parameters of myocardial mechanics at predicting advanced left-ventricle (LV) and right-ventricle (RV) fibrosis were compared using logistic regression analysis and receiver operating characteristic curve (ROC) analysis...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28629552/comparative-analysis-of-four-scores-to-stratify-patients-with-heart-failure-and-reduced-ejection-fraction
#7
Pedro Freitas, Carlos Aguiar, António Ferreira, António Tralhão, António Ventosa, Miguel Mendes
There are several prognostic risk scores available for patients with heart failure with reduced ejection fraction (HFrEF) that can aid in the decision of listing candidates for heart transplant (HTx). A direct comparison between these scores has not been performed. Therefore, our objective was to evaluate the calibration and discriminative power of 4 contemporary HF scores. A retrospective analysis of 259 patients with HFrEF who underwent cardiopulmonary exercise test was conducted. The Heart Failure Survival Score (HFSS), Seattle Heart Failure Model (SHFM), Meta-analysis Global Group in Chronic Heart Failure (MAGGIC), and Metabolic Exercise Cardiac Kidney Index (MECKI) were compared...
May 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28628144/-application-of-the-china-par-risk-prediction-model-for-atherosclerotic-cardiovascular-disease-in-a-rural-northern-chinese-population
#8
X Tang, D D Zhang, L He, Y Cao, J W Wang, N Li, S P Huang, H D Dou, P Gao, Y H Hu
OBJECTIVE: To validate five-year risk prediction models for atherosclerotic cardiovascular disease (ASCVD) in a contemporary rural Northern Chinese population. METHODS: Totally 6 489 rural adults aged 40 to 79 years without clinical ASCVD were enrolled at baseline between June and August 2010, and followed up through January 2017. Expected prediction risk using the China-PAR (prediction for ASCVD risk in China) model was compared with the pooled cohort equations (PCE) reported in the American College of Cardiology/American Heart Association guideline...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28626847/injury-intense-dust-exposure-and-chronic-disease-among-survivors-of-the-world-trade-center-terrorist-attacks-of-september-11-2001
#9
Howard E Alper, Shengchao Yu, Steven D Stellman, Robert M Brackbill
BACKGROUND: The World Trade Center attack of September 11, 2001 in New York City (9/11) exposed thousands of people to intense concentrations of hazardous materials that have resulted in reports of increased levels of asthma, heart disease, diabetes, and other chronic diseases along with psychological illnesses such as post-traumatic stress disorder (PTSD). Few studies have discriminated between health consequences of immediate (short-term or acute) intense exposures versus chronic residential or workplace exposures...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28620089/development-and-validation-of-risk-prediction-equations-to-estimate-survival-in-patients-with-colorectal-cancer-cohort-study
#10
Julia Hippisley-Cox, Carol Coupland
Objective To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design Cohort study.Setting General practices in England providing data for the QResearch database linked to the national cancer registry.Participants 44 145 patients aged 15-99 with colorectal cancer from 947 practices to derive the equations. The equations were validated in 15 214 patients with colorectal cancer from 305 different QResearch practices and 437 821 patients with colorectal cancer from the national cancer registry...
June 15, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28620070/prediction-of-adult-dyslipidemia-using-genetic-and-childhood-clinical-risk-factors-the-cardiovascular-risk-in-young-finns-study
#11
Joel Nuotio, Niina Pitkänen, Costan G Magnussen, Marie-Jeanne Buscot, Mikko S Venäläinen, Laura L Elo, Eero Jokinen, Tomi Laitinen, Leena Taittonen, Nina Hutri-Kähönen, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Jorma S Viikari, Markus Juonala, Olli T Raitakari
BACKGROUND: Dyslipidemia is a major modifiable risk factor for cardiovascular disease. We examined whether the addition of novel single-nucleotide polymorphisms for blood lipid levels enhances the prediction of adult dyslipidemia in comparison to childhood lipid measures. METHODS AND RESULTS: Two thousand four hundred and twenty-two participants of the Cardiovascular Risk in Young Finns Study who had participated in 2 surveys held during childhood (in 1980 when aged 3-18 years and in 1986) and at least once in a follow-up study in adulthood (2001, 2007, and 2011) were included...
June 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28619703/identifying-nonclinical-factors-associated-with-30-day-readmission-in-patients-with-cardiovascular-disease-protocol-for-an-observational-study
#12
Matthew E Dupre, Alicia Nelson, Scott M Lynch, Bradi B Granger, Hanzhang Xu, Janese M Willis, Lesley H Curtis, Eric D Peterson
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of hospitalization in older adults and high readmission rates have attracted considerable attention as actionable targets to promote efficiency in care and to reduce costs. Despite a plethora of research over the past decade, current strategies to predict readmissions have been largely ineffective and efforts to identify novel clinical predictors have been largely unsuccessful. OBJECTIVE: The objective of this study is to examine a wide array of socioeconomic, psychosocial, behavioral, and clinical factors to predict risks of 30-day hospital readmission in cardiovascular patients...
June 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28606604/the-ability-of-the-wide-range-crp-assay-to-classify-individuals-with-low-grade-inflammation-into-cardiovascular-risk-groups
#13
Tomer Ziv-Baran, Shani Shenhar-Tsarfaty, Inbal Etz-Hadar, Ilana Goldiner, Ahuva Gottreich, Yifat Alcalay, David Zeltser, Itzhak Shapira, Yoel Angel, Limor Friedensohn, Michal Ehrenwald, Shlomo Berliner, Ori Rogowski
BACKGROUND: High sensitivity C-reactive protein (hsCRP) has become a routine assessment tool to discriminate between patients at low, intermediate or high risk for cardiovascular events using the threshold values of 1 and 3mg/L, respectively. Over the past years, several studies have proposed the wide range C-reactive protein (wrCRP) as an alternative to the hsCRP in various clinical scenarios. However, the potential use of wrCRP in assessing the cardiovascular risk has not yet been evaluated...
June 9, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28602434/carotid-plaque-thickness-and-common-carotid-imt-show-additive-value-in-cardiovascular-risk-prediction-and-reclassification
#14
Mauro Amato, Fabrizio Veglia, Ulf de Faire, Philippe Giral, Rainer Rauramaa, Andries J Smit, Sudhir Kurl, Alessio Ravani, Beatrice Frigerio, Daniela Sansaro, Alice Bonomi, Calogero C Tedesco, Samuela Castelnuovo, Elmo Mannarino, Steve E Humphries, Anders Hamsten, Elena Tremoli, Damiano Baldassarre
BACKGROUND AND AIMS: Carotid plaque size and the mean common carotid intima-media thickness measured in plaque-free areas (PF CC-IMTmean) have been identified as predictors of vascular events (VEs), but their complementarity in risk prediction and stratification is still unresolved. The aim of this study was to evaluate the independence of carotid plaque thickness and PF CC-IMTmean in cardiovascular risk prediction and risk stratification. METHODS: The IMPROVE-study is a European cohort (n = 3703), where the thickness of the largest plaque detected in the whole carotid tree was indexed as cIMTmax...
May 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28601908/urinary-liver-type-fatty-acid-binding-protein-is-an-independent-predictor-of-stroke-and-mortality-in-individuals-with-type-1-diabetes
#15
Nicolae M Panduru, Carol Forsblom, Markku Saraheimo, Lena M Thorn, Daniel Gordin, Nina Elonen, Valma Harjusalo, Angelika Bierhaus, Per M Humpert, Per-Henrik Groop
AIMS/HYPOTHESIS: In type 1 diabetes, cardiovascular disease (CVD) and diabetic nephropathy progress in parallel, thereby potentiating the risk of premature death during their development. Since urinary liver-type fatty acid binding protein (L-FABP) predicts the progression of diabetic nephropathy, the aim of this study was to investigate whether urinary L-FABP also predicts cardiovascular outcomes and mortality. METHODS: We tested our hypothesis in a Finnish cohort of 2329 individuals with type 1 diabetes and a median follow-up of 14...
June 10, 2017: Diabetologia
https://www.readbyqxmd.com/read/28599201/serum-metabolome-biomarkers-associate-low-level-environmental-perfluorinated-compound-exposure-with-oxidative-nitrosative-stress-in-humans
#16
Xiaofei Wang, Liangpo Liu, Weibing Zhang, Jie Zhang, Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen
Previous in vivo and in vitro studies have linked perfluorinated compound (PFC) exposure with metabolic interruption, but the inter-species difference and high treatment doses usually make the results difficult to be extrapolated to humans directly. The best strategy for identifying the metabolic interruption may be to establish the direct correlations between monitored PFCs data and metabolic data on human samples. In this study, serum metabolome data and PFC concentrations were acquired for a Chinese adult male cohort...
June 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28596372/human-blood-monocyte-subsets-a-new-gating-strategy-defined-using-cell-surface-markers-identified-by-mass-cytometry
#17
Graham D Thomas, Anouk A J Hamers, Catherine Nakao, Paola Marcovecchio, Angela M Taylor, Chantel McSkimming, Anh Tram Nguyen, Coleen A McNamara, Catherine C Hedrick
OBJECTIVE: Human monocyte subsets are defined as classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(+)). Alterations in monocyte subset frequencies are associated with clinical outcomes, including cardiovascular disease, in which circulating intermediate monocytes independently predict cardiovascular events. However, delineating mechanisms of monocyte function is hampered by inconsistent results among studies. APPROACH AND RESULTS: We use cytometry by time-of-flight mass cytometry to profile human monocytes using a panel of 36 cell surface markers...
June 8, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28588089/role-of-circulating-fibroblast-growth-factor-21-measurement-in-primary-prevention-of-coronary-heart-disease-among-chinese-patients-with-type-2-diabetes-mellitus
#18
Chi Ho Lee, Yu Cho Woo, Wing Sun Chow, Chloe Yu Yan Cheung, Carol Ho Yi Fong, Michele Mae Ann Yuen, Aimin Xu, Hung Fat Tse, Karen Siu Ling Lam
BACKGROUND: Fibroblast growth factor 21 (FGF21) has demonstrated beneficial effects on lipid and carbohydrate metabolism. In cross-sectional studies, an association of raised circulating FGF21 levels with coronary heart disease (CHD) was found in some but not all studies. Here we investigated prospectively whether baseline serum FGF21 levels could predict incident CHD in subjects with type 2 diabetes mellitus and no known cardiovascular diseases. METHODS AND RESULTS: Baseline serum FGF21 levels were measured in 3528 Chinese subjects with type 2 diabetes mellitus recruited from the Hong Kong West Diabetes Registry...
June 6, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28585834/acute-consumption-of-flavan-3-ol-enriched-dark-chocolate-affects-human-endogenous-metabolism
#19
Luisa Martha Ostertag, Mark Philo, Ian J Colquhoun, Henri S Tapp, Shikha Saha, Garry G Duthie, E Kate Kemsley, Baukje de Roos, Paul A Kroon, Gwénaëlle Le Gall
Flavan-3-ols and methylxanthines have potential beneficial effects on human health including reducing cardiovascular risk. We performed a randomized controlled cross-over intervention trial to assess the acute effects of consumption of flavan-3-ol-enriched dark chocolate, compared with standard dark chocolate and white chocolate, on the human metabolome. We assessed the metabolome in urine and blood plasma samples collected before and at 2 h and 6 h after consumption of chocolates in 42 healthy volunteers using a non-targeted metabolomics approach...
June 6, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28582030/antiproliferative-drugs-for-restenosis-prevention
#20
REVIEW
Anwer Habib, Aloke Virmani Finn
Cardiovascular disease is a leading cause of death and disability worldwide. Current treatment strategies aimed at treating the symptoms and consequences of obstructive vascular disease have embraced both optimal medical therapy and catheter-based percutaneous coronary intervention with drug-eluting stents. Drug-eluting stents elute antiproliferative drugs inhibiting vascular smooth muscle cell proliferation, which occurs in response to injury and thus prevents restenosis. However, all drugs currently approved for use in drug-eluting stents do not discriminate between proliferating vascular smooth muscle cells and endothelial cells, thus delaying re-endothelialization and subsequent vascular healing...
July 2016: Interventional cardiology clinics
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