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https://www.readbyqxmd.com/read/28314800/performance-of-the-atherosclerotic-cardiovascular-disease-pooled-cohort-risk-equations-by-social-deprivation-status
#1
Lisandro D Colantonio, Joshua S Richman, April P Carson, Donald M Lloyd-Jones, George Howard, Luqin Deng, Virginia J Howard, Monika M Safford, Paul Muntner, David C Goff
BACKGROUND: The atherosclerosis cardiovascular disease (ASCVD) Pooled Cohort risk equations have shown different calibration across US populations with varied levels of social deprivation. METHODS AND RESULTS: We analyzed the calibration and discrimination of the Pooled Cohort risk equations by social deprivation status among 9066 REGARDS (REasons for Geographic And Racial Differences in Stroke) study participants not taking statins for whom ASCVD risk may lead to statin initiation...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28314798/insulin-like-growth-factor-binding-protein-4-fragments-provide-incremental-prognostic-information-on-cardiovascular-events-in-patients-with-st-segment-elevation-myocardial-infarction
#2
Rikke Hjortebjerg, Søren Lindberg, Sune Pedersen, Rasmus Mogelvang, Jan S Jensen, Claus Oxvig, Jan Frystyk, Mette Bjerre
BACKGROUND: Fragments of insulin-like growth factor binding protein 4 (IGFBP-4) are potential new biomarkers for cardiac risk assessment. The fragments are generated on specific cleavage by pregnancy-associated plasma protein-A, which exerts proatherogenic activity. This study investigated the prognostic value of IGFBP-4 fragments in patients with ST-segment elevation myocardial infarction. METHODS AND RESULTS: We prospectively included 656 patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention from September 2006 to December 2008...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28300429/leptin-predicts-short-term-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease
#3
Veli-Pekka Puurunen, Antti Kiviniemi, Samuli Lepojärvi, Olli-Pekka Piira, Pirjo Hedberg, Juhani Junttila, Olavi Ukkola, Heikki Huikuri
INTRODUCTION: Leptin is an adipose tissue-derived hormone associated with cardiovascular risk factors. We examined whether leptin predicts major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. METHODS: Fasting plasma leptin levels were measured in 1327 male and 619 female CAD patients. The patients were followed up for two years. The primary endpoint (MACE) was the composite of a hospitalisation for congestive heart failure (CHF) or a cardiac death...
March 16, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28299975/targeted-high-performance-liquid-chromatography-tandem-mass-spectrometry-based-metabolomics-differentiates-metabolic-syndrome-from-obesity
#4
Fanyi Zhong, Mengyang Xu, Richard S Bruno, Kevin D Ballard, Jiangjiang Zhu
Both obesity and the metabolic syndrome are risk factors for type 2 diabetes and cardiovascular disease. Identification of novel biomarkers are needed to distinguish metabolic syndrome from equally obese individuals in order to direct them to early interventions that reduce their risk of developing further health problems. We utilized mass spectrometry-based targeted metabolic profiling of 221 metabolites to evaluate the associations between metabolite profiles and established metabolic syndrome criteria (i...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28299500/mthfr-and-mthfd1-gene-polymorphisms-are-not-associated-with-pseudoexfoliation-syndrome-in-south-indian-population
#5
Prakadeeswari Gopalakrishnan, Aravind Haripriya, Periasamy Sundaresan
PURPOSE: Pseudoexfoliation syndrome (PEX) is a late onset disorder of extracellular matrix turnover, associated systemically with cardiovascular and cerebrovascular disease. To evaluate the suggested association of polymorphisms of homocysteine metabolism genes MTHFR (rs1801131, rs1801133) and MTHFD1 (rs8006686) with PEX. METHODS: A case-control association study was undertaken, comprising a total of 1472 individuals including 860 unrelated PEX cases and 612 ethnic-matched cataract controls (CC)...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28292623/additive-value-of-interleukin-6-and-c-reactive-protein-in-risk-prediction-for-all-cause-and-cardiovascular-mortality-among-a-representative-adult-cohort-in-taiwan
#6
Yu-Hsuan Lin, Dana Glei, Maxine Weinstein, Shiow-Ing Wu, Kuo-Liong Chien
BACKGROUND/PURPOSE: Interleukin-6 (IL-6) and C-reactive protein (CRP) are inflammatory makers of potential interest in all-cause and cardiovascular death risk prediction, but their additive explanatory value to established risk factors is not well documented among nonwestern populations. METHODS: We investigated the additive value of IL-6 and CRP to the Framingham risk score and lifestyle factors in predicting all-cause and cardiovascular mortality among a population-representative sample of 1023 adults aged 54 years and above in Taiwan...
March 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28292488/psychometric-evaluation-of-a-treatment-acceptance-measure-for-use-in-patients-receiving-treatment-via-subcutaneous-injection
#7
Sophi Tatlock, Rob Arbuckle, Robert Sanchez, Laura Grant, Irfan Khan, Garen Manvelian, John A Spertus
BACKGROUND: Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, significantly reduces low-density lipoprotein cholesterol, but requires subcutaneous injections rather than oral pills. To measure patients' acceptance of this treatment modality, a new patient-reported outcome, the Injection-Treatment Acceptance Questionnaire (I-TAQ), was developed. OBJECTIVES: To psychometrically evaluate the I-TAQ with patients at high risk of cardiovascular events receiving alirocumab...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28287268/nmr-based-lipid-profiling-of-high-density-lipoprotein-particles-in-healthy-subjects-with-low-normal-and-elevated-hdl-cholesterol
#8
Christina E Kostara, Vasilis Tsimihodimos, Moses S Elisaf, Eleni T Bairaktari
Recent studies suggest that the cholesterol content of HDL (High Density Lipoproteins) lipoproteins may provide limited information on their antiatherogenic properties and that the composition and particles' structure provide more information on their functionality. We used NMR-based (Nuclear Magnetic Resonance-based) lipidomics to study the relationships of serum HDL-C (HDL-Cholesterol) levels with the lipid composition of HDL particles in three groups of subjects selected on the basis of their HDL-C levels...
March 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28284500/combined-baseline-and-one-month-changes-in-big-endothelin-1-and-brain-natriuretic-peptide-plasma-concentrations-predict-clinical-outcomes-in-patients-with-left-ventricular-dysfunction-after-acute-myocardial-infarction-insights-from-the-eplerenone-post-acute
#9
A Olivier, N Girerd, J B Michel, J M Ketelslegers, R Fay, J Vincent, P Bramlage, B Pitt, F Zannad, P Rossignol
OBJECTIVE: Increased levels of neuro-hormonal biomarkers predict poor prognosis in patients with acute myocardial infarction (AMI) complicated by left ventricular systolic dysfunction (LVSD). The predictive value of repeated (one-month interval) brain natriuretic peptides (BNP) and big-endothelin 1 (BigET-1) measurements were investigated in patients with LVSD after AMI. METHODS: In a sub-study of the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS trial), BNP and BigET-1 were measured at baseline and at 1month in 476 patients...
February 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28280695/cardiovascular-disease-risk-factors-and-applicability-of-a-risk-model-in-a-greek-cohort-of-renal-transplant-recipients
#10
Nikolaos-Andreas Anastasopoulos, Evangelia Dounousi, Evangelos Papachristou, Charalampos Pappas, Eleni Leontaridou, Eirini Savvidaki, Dimitrios Goumenos, Michael Mitsis
AIM: To investigate the incidence and the determinants of cardiovascular morbidity in Greek renal transplant recipients (RTRs) expressed as major advance cardiac event (MACE) rate. METHODS: Two hundred and forty-two adult patients with a functioning graft for at least three months and available data that were followed up on the August 31, 2015 at two transplant centers of Western Greece were included in this study. Baseline recipients' data elements included demographics, clinical characteristics, history of comorbid conditions and laboratory parameters...
February 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28279654/bloodstream-amyloid-beta-1-40-peptide-cognition-and-outcomes-in-heart-failure
#11
Antoni Bayes-Genis, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Joan Vila, Isaac Subirana, Paloma Gastelurrutia, M Cruz Pastor, James L Januzzi, Josep Lupón
INTRODUCTION AND OBJECTIVES: In the brain, amyloid-beta generation participates in the pathophysiology of cognitive disorders; in the bloodstream, the role of amyloid-beta is uncertain but may be linked to sterile inflammation and senescence. We explored the relationship between blood levels of amyloid-beta 1-40 peptide (Aβ40), cognition, and mortality (all-cause, cardiovascular, and heart failure [HF]-related) in ambulatory patients with HF. METHODS: Bloodstream Aβ40 was measured in 939 consecutive patients with HF...
March 6, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28278452/identification-of-ultrasonic-echolucent-carotid-plaques-using-discrete-fr%C3%A3-chet-distance-between-bimodal-gamma-distributions
#12
Xiaowei Huang, Yanling Zhang, Long Meng, Ming Qian, Kelvin Wong, Derek Abbott, Rongqin Zheng, Hairong Zheng, Lili Niu
OBJECTIVE: Echolucent carotid plaques are associated with acute cardiovascular and cerebrovascular events (ACCEs) in atherosclerotic patients. The aim of this study was to develop a computer-aided method for identifying echolucent plaques. METHODS: A total of 315 ultrasound images of carotid plaques (105 echo-rich, 105 intermediate and 105 echolucent) collected from 153 patients were included in this study. A bimodal gamma distribution was proposed to model the pixel statistics in the gray scale images of plaques...
March 1, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28275165/predicting-cardiovascular-events-in-familial-hypercholesterolemia-the-safeheart-registry
#13
Leopoldo Pérez de Isla, Rodrigo Alonso, Nelva Mata, Cristina Fernández-Pérez, Ovidio Muñiz, José Luis Díaz-Díaz, Adriana Saltijeral, Francisco J Fuentes-Jiménez, Raimundo de Andrés, Daniel Zambón, Mar Piedecausa, José María Cepeda, Marta Mauri, Jesús Galiana, Ángel Brea, Juan F Sanchez Muñoz-Torrero, Teresa Padró, Rosa Argueso, José Pablo Miramontes-González, Lina Badimón, Raúl D Santos, Gerald F Watts, Pedro Mata
Background -Although risk factors for atherosclerotic cardiovascular disease (ASCVD) in familial hypercholesterolaemia (FH) have been described, models for predicting incident ASCVD have not been reported. Our aim was to utilise the SAFEHEART registry to define key risk factors for predicting incident ASCVD in patients with FH. Methods -SAFEHEART is a multicentre, nationwide, long-term prospective cohort study of a molecularly-defined population with FH, with or without previous ASCVD. Analysis to define risk factors and to build a risk prediction equation were developed and tested for its ability to discriminate patients who experience incident ASCVD from those who did not over time...
March 8, 2017: Circulation
https://www.readbyqxmd.com/read/28274246/decreased-cytokine-production-by-mononuclear-cells-after-severe-gram-negative-infections-early-clinical-signs-and-association-with-final-outcome
#14
Nikolaos Antonakos, Thomas Tsaganos, Volker Oberle, Iraklis Tsangaris, Malvina Lada, Aikaterini Pistiki, Nikolaos Machairas, Maria Souli, Michael Bauer, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood. METHODS: We conducted a substudy of a large randomised clinical trial. Peripheral blood mononuclear cells (PBMCs) were isolated within the first 24 h from the onset of systemic inflammatory response syndrome in 95 patients with microbiologically confirmed or clinically suspected gram-negative infections...
March 9, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28273175/development-of-a-new-risk-model-for-predicting-cardiovascular-events-among-hemodialysis-patients-population-based-hemodialysis-patients-from-the-japan-dialysis-outcome-and-practice-patterns-study-j-dopps
#15
Yukiko Matsubara, Miho Kimachi, Shingo Fukuma, Yoshihiro Onishi, Shunichi Fukuhara
BACKGROUND: Cardiovascular (CV) events are the primary cause of death and becoming bedridden among hemodialysis (HD) patients. The Framingham risk score (FRS) is useful for predicting incidence of CV events in the general population, but is considerd to be unsuitable for the prediction of the incidence of CV events in HD patients, given their characteristics due to atypical relationships between conventional risk factors and outcomes. We therefore aimed to develop a new prognostic prediction model for prevention and early detection of CV events among hemodialysis patients...
2017: PloS One
https://www.readbyqxmd.com/read/28269115/detection-of-mental-stress-due-to-oral-academic-examination-via-ultra-short-term-hrv-analysis
#16
R Castaldo, W Xu, P Melillo, L Pecchia, L Santamaria, C James
Mental stress may cause cognitive dysfunctions, cardiovascular disorders and depression. Mental stress detection via short-term Heart Rate Variability (HRV) analysis has been widely explored in the last years, while ultra-short term (less than 5 minutes) HRV has been not. This study aims to detect mental stress using linear and non-linear HRV features extracted from 3 minutes ECG excerpts recorded from 42 university students, during oral examination (stress) and at rest after a vacation. HRV features were then extracted and analyzed according to the literature using validated software tools...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268429/identifying-glaucoma-patients-by-applying-multivariate-analyses-of-cardiovascular-signals
#17
Andreas Voss, Claudia Fischer, Cristina Gonzalez Martinez, Eva Koch, Niklas Plange, Kathleen Kunert
Glaucoma is a disease that damages the eye's optic nerve. However, the exact cause of this optic nerve damage is not yet fully understood. Besides the factors of age, genetics and others, such as obesity, medication and migraines, a vascular dysfunction is believed to be a significant factor leading to glaucoma. This study's objective was to investigate whether these vascular dysfunctions could be recognized by analyzing cardiovascular regulation in glaucoma patients. Linear and nonlinear methods were applied to the extracted heart rate (HR), and systolic/ diastolic blood pressure (DBP) time series to discriminate between 35 healthy controls and 20 glaucoma patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268258/cha2ds2-vasc-scores-predict-major-adverse-cardiovascular-events-in-patients-with-chronic-obstructive-pulmonary-disease
#18
Hean Ooi, Li-Hsiou Chen, Yung-Lun Ni, Huan-Ting Shen, Yen-Hsien Lee, Yi-Chun Chu, Ke-Chih Fang, I-Hung Chen, Shu-Lan Hsu, Hsing-Chun Chen, Chien-Hsiu Huang, Kuo-Sheng Fan, Chun-Liang Lai, Liang-Wen Hang
INTRODUCTION: Patients with chronic obstructive pulmonary disease (COPD) frequently experience concurrent comorbidities; therefore, risk assessment for major adverse cardiovascular events (MACEs) is very important. OBJECTIVES: We explored the association between COPD and risk of MACEs with three common clinical events: acute myocardial infarction (AMI), ischemic stroke (IS), and cardiovascular death (CVD). METHODS: We evaluated the predictive value of the CHA2DS2-VASc score (congestive heart failure [C], hypertension [H), age [A], diabetes [D), stroke [S], and vascular disease [VASc]) for MACEs in COPD patients...
March 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28255559/urinary-sodium-concentration-is-an-independent-predictor-of-all-cause-and-cardiovascular-mortality-in-a-type-2-diabetes-cohort-population
#19
Pierre-Jean Saulnier, Elise Gand, Stéphanie Ragot, Lise Bankir, Xavier Piguel, Frédéric Fumeron, Vincent Rigalleau, Jean-Michel Halimi, Richard Marechaud, Ronan Roussel, Samy Hadjadj, Surdiagene Study Group
Objective. Sodium intake is associated with cardiovascular outcomes. However, no study has specifically reported an association between cardiovascular mortality and urinary sodium concentration (UNa). We examined the association of UNa with mortality in a cohort of type 2 diabetes (T2D) patients. Methods. Patients were followed for all-cause death and cardiovascular death. Baseline UNa was measured from second morning spot urinary sample. We used Cox proportional hazard models to identify independent predictors of mortality...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28253222/phenotyping-of-myocardial-fibrosis-in-hypertensive-patients-with-heart-failure-influence-on-clinical-outcome
#20
Susana Ravassa, Begoña López, Ramón Querejeta, Kattalin Echegaray, Gorka San José, María U Moreno, Francisco J Beaumont, Arantxa González, Javier Díez
OBJECTIVE: Myocardial fibrosis is associated with alterations in the cross-linking and deposition of collagen type I (CCL and CD, respectively). We aimed to evaluate whether the combination of circulating biomarkers of CCL [the carboxy-terminal telopeptide of collagen type I to matrix metalloproteinase-1 ratio (CITP : MMP-1)] and CD [the carboxy-terminal propeptide of procollagen type I (PICP)] identifies myocardial fibrosis phenotypes with distinct clinical outcome in hypertensive patients with heart failure...
April 2017: Journal of Hypertension
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