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Mostefa Moubri, Christophe Burucoa, Nicolas Kalach, R Rezki Larras, Nouria Nouar, Fawsia Mouffok, Zakia Arrada
We aimed to evaluate in an Algerian pediatric population the diagnostic performances of the IDEIA HpStAR noninvasive stool antigen test (Oxoid, Cambridge, UK) to detect Helicobacter pylori infection before and after eradication therapy. A prospective study including 158 symptomatic Algerian children was conducted. Patients were initially diagnosed with invasive (culture, histology, and rapid urease test) and noninvasive tests (urea breath test and IDEIA HpStAR test). Infected patients were treated, and 101 were controlled after treatment with two invasive (culture and histology) and two noninvasive tests (urea breath test and IDEIA HpStAR test)...
July 10, 2018: Journal of Tropical Pediatrics
Robert Strassl, Martin Schiemann, Konstantin Doberer, Irene Görzer, Elisabeth Puchhammer-Stöckl, Farsad Eskandary, Željko Kikic, Guido A Gualdoni, Mathias G Vossen, Susanne Rasoul-Rockenschaub, Harald Herkner, Georg A Böhmig, Gregor Bond
Background: Drug-induced immunosuppression following kidney transplantation is crucial to prevent allograft rejection, but increases risk for infectious disease. Tailoring of drug dosing to prevent both rejection and infection is greatly desirable. The apathogenic and ubiquitous torque teno virus (TTV) reflects immunocompetence of the host and might be a potential candidate for immunologic monitoring. Methods: To assess TTV as an infection biomarker, virus load was prospectively quantified in peripheral blood of 169 consecutive renal allograft recipients at the Medical University Vienna...
July 11, 2018: Journal of Infectious Diseases
Andrew Zikic, Holger Schünemann, Teodora Wi, Ornella Lincetto, Nathalie Broutet, Nancy Santesso
Background: With the continued high prevalence of chlamydia worldwide and high risk of transfer from mothers to their infant during delivery, a need for safe and effective therapies for infants who acquire a chlamydial infection remains. We conducted a systematic review and meta-analysis of antibiotic treatments, including oral erythromycin, azithromycin, and trimethoprim, for neonatal chlamydial conjunctivitis. Methods: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from their inception to July 14, 2017...
July 10, 2018: Journal of the Pediatric Infectious Diseases Society
Christie Jackson, Brandon J Weiss, Marylene Cloitre
Introduction: Group Skills Training in Affective and Interpersonal Regulation (STAIR) is an evidence-based, manualized treatment for individuals with post-traumatic stress symptoms, that focuses on improving functioning through mood management (e.g., emotion regulation) and relationship skills development. To date, no study has evaluated the potential benefit of group STAIR among Veterans. Feasibility of delivering STAIR in a mixed-gender group format and the potential impact of gender on outcome were examined...
July 11, 2018: Military Medicine
Waqar Haque, Vivek Verma, Sandra Hatch, V Suzanne Klimberg, E Brian Butler, Bin S Teh
PURPOSE: Multiple ongoing randomized studies are assessing the impact of omission of chemotherapy (CT) in low-risk node-positive Luminal A breast. The goal of this investigation was to evaluate trends and practice patterns of adjuvant CT use in Luminal A pT1-3N1 breast cancer, along with determining the clinical benefit from adjuvant CT in this patient population. METHODS: The National Cancer Data Base was queried (2004-2014) for women with pT1-3N1 luminal A invasive ductal carcinoma receiving adjuvant hormonal therapy (HT)...
July 2, 2018: Breast: Official Journal of the European Society of Mastology
Marco Possanzini, Carlo Greco
The treatment of metastatic breast cancer is largely focused on systemic therapy. However, over the past decades, there has been growing interest in the use of metastasis-directed therapy in selected cases presenting with an oligometastatic phenotype, i.e. low disease burden with a more indolent biology. Identification of the oligometastatic breast cancer population has, so far, proven elusive. Stereotactic radiotherapy offers an effective, non-invasive approach to ablate metastatic disease both in the brain and in extra-cranial settings...
June 28, 2018: Breast: Official Journal of the European Society of Mastology
Yuan Lin Zhang, Xiu E Feng, Rong Rong Chang, Le Hua Zhang, Bao Guo Xiao, Qing Shan Li, Xu Liang Hao
Antibiotics are still the primary therapy for acute pyelonephritis (APN); rarely, natural polyphenols are also used. LM49 is a novel marine bromophenol derivative displaying strong anti-inflammatory effects. We investigated the therapeutic efficacy of LM49 in an experimental rat model of APN. The model was established by injecting 0.5 mL Escherichia coli (ATCC 25922, 108  CFU/mL) into the urinary bladders of Sprague Dawley rats. This model showed increased kidney viscera indices and renal bacterial growth scores, as well as pathological changes in kidneys...
July 11, 2018: International Immunopharmacology
Yunjian Zhang, Shuizhen Zhou, Yuanfeng Zhou, Lifei Yu, Linmei Zhang, Yi Wang
OBJECTIVE: The aim of this study was to investigate the characteristics and composition of intestinal microbiota in children with refractory epilepsy after ketogenic diet (KD) therapy and to explore the bacterial biomarkers related to clinical efficacy. METHODS: We prospectively analyzed 20 patients (14 males, 6 females) treated with KD. Clinical efficacy, electroencephalogram (EEG) changes, and laboratory tests were evaluated, and fecal specimens were obtained prior to and 6 months after therapy...
June 28, 2018: Epilepsy Research
Jiahuan Zou, Mengwei Zhuang, Xiaopeng Yu, Na Li, Rudi Mao, Zhida Wang, Jianing Wang, Xiaoyan Wang, Huaiyu Zhou, Lining Zhang, Yongyu Shi
The effectiveness of immunotherapy targeting the immune checkpoint PD-L1/PD-1 pathway highlights importance of elucidating the regulatory mechanisms of PD-L1 expression in cancer cells. Previous studies demonstrate that oncogene MYC up-regulates PD-L1 expression in lymphomas. In the present study, we investigated the regulatory role of MYC in the PD-L1 expression induced by IFN-γ in HCC cells. Unexpectedly, knockdown of MYC expression using siRNA assay increased the inducible expression of PD-L1 both at mRNA and protein levels...
July 5, 2018: Molecular Immunology
Laura Avanzino, Giovanna Lagravinese, Giovanni Abbruzzese, Elisa Pelosin
BACKGROUND: Disturbance of gait is a key feature of Parkinson's disease (PD) and has a negative impact on quality of life. Deficits in cognition and sensorimotor processing impair the ability of people with PD to walk quickly, efficiently and safely. Recent evidence suggests that emotional disturbances may also affect gait in PD. RESEARCH QUESTION: We explored if there were relationships between walking ability, emotion and cognitive impairment in people with PD...
June 28, 2018: Gait & Posture
María B Sánchez, Ian Loram, Paul Holmes, John Darby, Penelope B Butler
BACKGROUND: Physical therapy evaluations of motor control are currently based on subjective clinical assessments. Despite validation, these can still be inconsistent between therapists and between clinics, compromising the process of validating a therapeutic intervention and the subsequent generation of evidence-based practice (EBP) guidelines. EBP benefits from well-defined objective measurements that complement existing subjective assessments. RESEARCH QUESTION: The aim of this study was to develop an objective measure of head/trunk control in children with Cerebral Palsy (CP) using previously developed video-based methods of head/trunk alignment and absence of external support and compare these with the existing subjective Segmental Assessment of Trunk Control (SATCo)...
June 30, 2018: Gait & Posture
Yanni Zhang, Ying Chen, Hongchao Kou, Pengfei Yang, Yanen Wang, Tingli Lu
To improve the bone healing efficiency of porous titanium implants, desired biological properties of implants are mandatory, involving bioactivity, osteoconductivity, osteoinductivity and a stable environment. In this study, bare porous titanium (abbr. pTi) with the porosity of 70% was fabricated by vacuum diffusion bonding of titanium meshes. Hydroxyapatite-coated pTi (abbr. Hap-pTi) was obtained by successively subjecting pTi to alkali heat treatment, pre-calcification and simulated body fluid. Both pTi and Hap-pTi were respectively implanted into the tibia defect model (ϕ10 mm × 6 mm) in New Zealand white rabbits, then subjected to non-invasively axial compressive loads at high-magnitude low-frequency (HMLF), which were denoted as F-pTi and F-Hap-pTi, respectively...
June 28, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Vittorio Pengo, Gentian Denas
Antiphospholipid Syndrome (APS) is a condition characterized by the occurrence of thromboembolic events and/or pregnancy loss combined with one laboratory criterion among Lupus Anticoagulant- LAC, anticardiolipin -aCL, and anti β2-Glycoprotein I -aβ2GPI antibodies. Several hypotheses were put forward to explain the causal role of antibodies in the clinical events but none is fully convincing. Current laboratory diagnosis is based on three tests (LAC, IgG/IgM aβ2GPI and IgG/IgM aCL antibodies). The triple-positive profile (all the three tests positive, same isotype) is associated with a higher risk for thrombosis...
July 7, 2018: Thrombosis Research
Luca Zanella, Giacomo Zoppellaro, Lucia Marigo, Gentian Denas, Seena Padayattil Jose, Vittorio Pengo
BACKGROUND: Intracranial haemorrhage (ICH) is the most fearful side effect of oral anticoagulant therapy. It is still unclear which risk factor is involved in ICH during vitamin K antagonists (VKAs) treatment and if commonly used bleeding risk scores are able to predict ICH. PURPOSE: Search for individual risk factors and bleeding risk scores (HAS-BLED, ATRIA and ORBIT) associated with ICHs in patients with atrial fibrillation treated with VKAs. METHODS: This is a retrospective case-control study in a single Thrombosis Centre...
July 14, 2018: Cardiovascular Therapeutics
Yasuyoshi Morita, Yasuhiro Maeda, Terufumi Yamaguchi, Fumiaki Urase, Shuhei Kawata, Hitoshi Hanamoto, Kazuo Tsubaki, Jun Ishikawa, Hirohiko Shibayama, Itaru Matsumura, Mitsuhiro Matsuda
Although azacitidine is the first-line drug for higher-risk MDS patients, its efficacy for lower-risk MDS remains unestablished. So, we conducted a prospective study to examine the efficacy and safety of a 5-day regimen of azacitidine (AZA-5) for lower-risk MDS. The primary endpoint was hematological improvement (HI) after 4 courses of therapy. A total of 51 patients with lower-risk MDS by FAB classification (RA 44 patients and RARS 7 patients) were enrolled from 6 centers in Japan. The median age was 75 years (range: 51-88)...
July 14, 2018: Cancer Science
Joanna Zawitkowska, Monika Lejman, Agnieszka Zaucha-Prażmo, Katarzyna Drabko, Marcin Płonowski, Joanna Bulsa, Michał Romiszewski, Agnieszka Mizia-Malarz, Andrzej Kołtan, Katarzyna Derwich, Grażyna Karolczyk, Tomasz Ociepa, Magdalena Ćwiklińska, Joanna Trelińska, Joanna Owoc-Lempach, Maciej Niedźwiecki, Aleksandra Kiermasz, Jerzy Kowalczyk
OBJECTIVE: The aim of this study was to analyse the clinical characteristics and outcome of children diagnosed with Ph+ ALL. MATERIAL AND METHODS: A total of 2591 newly diagnosed ALL children were treated in Poland between the years 2005-2017. Of those, 44 were diagnosed with Ph(+) ALL. The patients were treated according to protocols: ALL IC - BFM 2002 and 2009 (26 patients), EsPhALL (12 patients), initially ALL IC - BFM and then EsPhALL (6 patients). RESULTS: The median of follow up in the observed group was 3 years...
July 14, 2018: European Journal of Haematology
M Moteabbed, A Trofimov, F H Khan, Y Wang, G C Sharp, A L Zietman, J A Efstathiou, H-M Lu
PURPOSE: Hypofractionated radiotherapy of prostate cancer is gaining clinical acceptance given its potential increase in therapeutic ratio and evidence for noninferiority and lack of added late toxicities compared to conventional fractionation. However, concerns have been raised that smaller number of fractions might lead to larger dosimetric influence by interfractional motion. We aim to compare the effect of these variations on hypofractionated pencil beam scanning (PBS) proton therapy and volumetric modulated arc therapy (VMAT) for localized prostate cancer...
July 14, 2018: Medical Physics
Tiago Cardoso, Andrew Adler, Bengt Mattsson, Deirdre B Hoban, Sara Nolbrant, Jenny Nelander Wahlestedt, Agnete Kirkeby, Shane Grealish, Anders Björklund, Malin Parmar
Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are a promising unlimited source of cells for cell replacement therapy in Parkinson´s disease (PD). A number of studies have demonstrated functionality of DA neurons originating from hESCs when grafted to the striatum of rodent and non-human primate models of PD. However, several questions remain in regard to their axonal outgrowth potential and capacity to integrate into host circuitry. Here, VM patterned hESC-derived progenitors were grafted into the midbrain of 6-hydroxydopamine-lesioned rats, and analyzed at 6, 18 and 24 weeks for a time-course evaluation of specificity and extent of graft-derived fiber outgrowth as well as potential for functional recovery...
July 14, 2018: Journal of Comparative Neurology
Wilai Thanasarnaksorn, Sebastian Cotofana, Christina Rudolph, Patcharahatai Kraisak, Nongsak Chanasumon, Atchima Suwanchinda
Hyaluronic acid (HA) injection is a popular nonsurgical, facial rejuvenating procedure. Due to the rapidly expanding use of HA injections, significant potential complications have also increased in frequency. Among these complications, the rare but most devastating one is arterial occlusion, which can result in skin necrosis or blindness. To describe the mechanisms behind vision loss secondary to hyaluronic acid injection and the efficacy of treatments to restore vision and associated ocular functionality. We reviewed six cases of patients from October 2011 to December 2017 who experienced vision loss after receiving facial HA injections and the subsequent treatments undertaken to attempt to reverse the vision loss and additional eye complications...
July 13, 2018: Journal of Cosmetic Dermatology
Susanna Hegewisch-Becker, Ali Aldaoud, Thomas Wolf, Beate Krammer-Steiner, Hartmut Linde, Renate Scheiner-Sparna, David Hamm, Martina Jänicke, Norbert Marschner
Pancreatic cancer is a highly lethal malignancy. Developments in recent years have broadened our therapeutic armamentarium. Novel drugs such as nab-paclitaxel, liposomal irinotecan and chemotherapy regimens such as FOLFIRINOX have been successfully tested in clinical trials. Data on patients outside of clinical trials are scarce but necessary to assess and improve the standard of care. We present data on treatment and survival of 1,174 patients with locally advanced, inoperable or metastatic pancreatic ductal adenocarcinoma...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
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