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Antimicrobial surveillance

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https://www.readbyqxmd.com/read/28923605/microbial-pathogenicity-and-virulence-mediated-by-integrons-on-gram-positive-microorganisms
#1
REVIEW
Yanmei Li, Ling Yang, Jie Fu, Muxia Yan, Dingqiang Chen, Li Zhang
Gram-positive microorganisms are one of leading pathogenic microorganisms in public health, including several typical "Super Bugs" as methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae carbapenemase and vancomycin-resistant enterococci, which caused a increasement of infections, clinical failures and expenses. Regarded as a common genetic element responsible for horizontal gene transfer, integrons are widely distributed in various pathogens considered as a determinant in the acquisition and evolution of antibiotic resistance...
September 15, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28923377/clinical-and-analytical-evaluation-of-the-new-aptima-mycoplasma-genitalium-assay-with-data-on-m-genitalium-prevalence-and-antimicrobial-resistance-in-m-genitalium-in-denmark-norway-and-sweden-in-2016
#2
M Unemo, K Salado-Rasmussen, M Hansen, A O Olsen, M Falk, D Golparian, M Aasterød, J Ringlander, C Steczkó Nilsson, M Sundqvist, K Schønning, H Moi, H Westh, J S Jensen
OBJECTIVES: Mycoplasma genitalium (MG) causes urethritis and cervicitis, potentially causing reproductive complications. Resistance in MG to first-line (azithromycin) and second-line (moxifloxacin) treatment has increased. We examined the clinical and analytical performance of the new CE/IVD Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic); the prevalence of MG, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG); and MG resistance to azithromycin and moxifloxacin in Denmark, Norway and Sweden in 2016...
September 15, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28922838/comparative-genomics-of-a-drug-resistant-pseudomonas-aeruginosa-panel-and-the-challenges-of-antimicrobial-resistance-prediction-from-genomes
#3
J Jeukens, I Kukavica-Ibrulj, J G Emond-Rheault, L Freschi, R C Levesque
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The accessibility of microbial whole-genome sequencing offers an invaluable opportunity for resistance surveillance via the resistome, i.e. the genes and mutations underlying AMR. Unfortunately, AMR prediction from genomic data remains extremely challenging, especially for species with a large pan-genome. One such organism, for which multidrug-resistant (MDR) isolates are frequently encountered in the clinic, is Pseudomonas aeruginosa...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28921905/antibiotic-resistant-escherichia-coli-in-southeastern-australian-pig-herds-and-implications-for-surveillance
#4
L K van Breda, O P Dhungyel, M P Ward
To investigate public health implications of antibiotics to control post-weaning scours, we surveyed 22 commercial pig herds in southeastern Australia. Fifty faecal samples per herd were collected from pre- and post-weaned piglets. Presumptive Escherichia coli isolates were confirmed by MALDI-TOF MS. Isolates (n = 325) were screened for susceptibility to 19 veterinary antibiotics using MIC broth microdilution. All 325 E. coli isolates underwent further testing against 27 antibiotics used in human medicine and were screened for ETEC adhesin and enterotoxin genes (F4 (K88), F5 (K99), F6 (987P), F18, F41, STa, STb, Stx2e and LT) by multiplex PCR...
September 17, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28919603/current-trends-of-using-antimicrobials-at-obstetrics-and-gynaecology-department-in-a-tertiary-care-hospital
#5
M M Islam, S K Saha, S Saha, U A Wahid, R R Gomes, K S Ahmed, A N Naushad, S E Suchi, C Saha, D Mondal
This cross-sectional descriptive study was done to analyse the current trends of using antimicrobials in various surgical procedures at Obstetrics and Gynaecology department in Mymensingh Medical College Hospital, Mymensingh from July 2014 to June 2015. Among 300 postoperative obstetrics and gynaecological surgery cases, samples were selected as non-random purposive selection method where pattern of using antimicrobials were analysed by SPSS method 20.1 versions. The incidence of antimicrobial resistance is on continued rise with a threat to return to the pre-antibiotic era...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28904263/concerning-increase-in-antimicrobial-resistance-in-shiga-toxin-producing-escherichia-coli-isolated-from-young-animals-during-1980-2016
#6
Flore Chirila, Alexandra Tabaran, Nicodim Fit, George Nadas, Marian Mihaiu, Flaviu Tabaran, Cornel Cătoi, Oana Lucia Reget, Sorin Daniel Dan
This study was conducted in order to assess the antimicrobial resistance patterns of E. coli isolated from young animals affected between 1980 and 2016. The selected isolates for this study (n=175) carried stx1/stx2 genes and the most prevalent type of pathogenic E. coli found belonged to serogroup O101, antigen (K99)-F41 positive. All STEC-positive isolates were tested for susceptibility to 11 antimicrobials. Multidrug resistance (MDR) increased from 11% during the 1980s to 40% between 2000 and 2016. Resistance to tetracycline and streptomycin was the most frequent co-resistance phenotype (37%)...
September 12, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28895051/polymyxin-resistance-in-gram-negative-pathogens
#7
REVIEW
Pavithra Srinivas, Kaitlyn Rivard
PURPOSE OF REVIEW: The polymyxins are one of the last line antimicrobial classes to retain activity against multidrug-resistant Gram-negative bacilli. However, with the increased use of polymyxins in recent years, reports of resistance have also been increasing. We aimed to describe the mechanisms and occurrence of polymyxin resistance in Gram-negative organisms and propose strategies to overcome resistance. RECENT FINDINGS: The most common mechanism of acquired resistance to the polymyxins is via modification of the bacterial outer membrane lipopolysaccharide...
September 11, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28893751/non-typhoidal-salmonella-in-calabria-italy-a-laboratory-and-patient-based-survey
#8
Valentina Mascaro, Claudia Pileggi, Maria Crinò, Yolande Therese Rose Proroga, Maria Rosaria Carullo, Caterina Graziani, Fabio Arigoni, Pasquale Turno, Maria Pavia
INTRODUCTION: Although there has been a decrease in the number of cases of salmonellosis in the European Union, it still represents the primary cause of foodborne outbreaks. In Calabria region, data are lacking for the incidence of human non-typhoid salmonellosis as active surveillance has never been carried out. OBJECTIVE: To report the results of a laboratory and patient-based morbidity survey in Calabria to describe the incidence and distribution of Salmonella serovars isolated from humans, with a focus on antimicrobial resistance patterns...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28893672/a-situational-analysis-of-current-antimicrobial-governance-regulation-and-utilisation-in-south-africa
#9
Natalie Schellack, Deon Benjamin, Adrian Brink, Adriano Duse, Kim Faure, Debra Goff, Marc Mendelson, Johanna Meyer, Jacqui Miot, Olga Perovic, Troy Pople, Fatima Suleman, Moritza van Vuuren, Sabiha Essack
The Global Action Plan (GAP) on AMR calls for optimising the use of antimicrobial medicines in human and animal health, in tandem with strengthening of the knowledge and evidence base through surveillance and research. However, there is a paucity of consumption data in African countries such as South Africa. Determining antimicrobial consumption data in low resource settings remains a challenge. This paper describes alternative mechanisms of assessing antimicrobial consumption data such as Intercontinental Marketing Services (IMS), and contract data arising from tenders (an open Request for Proposal, RFP) as opposed to the international norms of daily defined doses per 100 patient days, or per 1000 of the population...
September 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28893203/overall-low-extended-spectrum-cephalosporin-resistance-but-high-azithromycin-resistance-in-neisseria-gonorrhoeae-in-24-european-countries-2015
#10
Michelle J Cole, Gianfranco Spiteri, Susanne Jacobsson, Neil Woodford, Francesco Tripodo, Andrew J Amato-Gauci, Magnus Unemo
BACKGROUND: Surveillance of Neisseria gonorrhoeae antimicrobial susceptibility in Europe is performed through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP), which additionally provides data to inform the European gonorrhoea treatment guideline; currently recommending ceftriaxone 500 mg plus azithromycin 2 g as first-line therapy. We present antimicrobial susceptibility data from 24 European countries in 2015, linked to epidemiological data of patients, and compare the results to Euro-GASP data from previous years...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28893195/antimicrobial-resistance-in-bacterial-pathogens-among-hospitalized-children-with-community-acquired-lower-respiratory-tract-infections-in-dongguan-china-2011-2016
#11
Xiaoguang He, Mingyu Xie, Siping Li, Junqin Ye, Qi Peng, Qiang Ma, Xiaomei Lu, Baimao Zhong
BACKGROUND: Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bacterial agents among hospitalized children with CA-LRTIs between 2011 and 2016 in Dongguan, China. METHODS: Sputum samples were collected from hospitalized children (0-5 years old) with CA-LRTIs in Dongguan Children's Hospital...
September 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28892887/active-surveillance-of-health-care-associated-infections-in-neurosurgical-patients
#12
Reshu Agarwal, Sarita Mohapatra, Girija Prasad Rath, Arti Kapil
INTRODUCTION: Health Care Associated Infections (HCAI) are frequent complications in neurosurgery. There is limited data available on the incidence and burden of HCAI in neurosurgical patients of Southeast Asian region. AIM: To identify various HCAIs, associated aetiological agents and their antimicrobial susceptibility pattern among the patients admitted in the neurosurgery unit. MATERIALS AND METHODS: An observational prospective study was carried out for three months duration on all neurosurgical patients admitted to a tertiary-care center...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891372/controversies-and-advances-in-the-management-of-ventilator-associated-pneumonia
#13
Katherine L Roberts, Marin H Kollef, Scott T Micek, Paul Juang
Although national surveillance data suggests that the incidence of ventilator associated pneumonia (VAP) is down-trending, it remains one of the most commonly encountered hospital acquired infections in the United States and worldwide. Its association with increased healthcare costs and worsened patient outcomes warrants continued effort to improve the care of patients with VAP. Areas covered: The increasing prevalence of multi-drug resistant bacteria further drives the need to explore advances in diagnostic and treatment options...
September 11, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28888884/prevalence-of-antimicrobial-resistance-and-integron-gene-cassettes-in-escherichia-coli-isolated-from-yaks-poephagus-grunniens-in-aba-tibetan-autonomous-prefecture-china
#14
Xin Yang, Wencheng Zou, Jinxin Zeng, Shengze Xie, Tianwu An, Xiaolin Luo, Danyu Chen, Lan Feng, Guangyang Cheng, Run Cai, Qianru Huang, Hongning Wang
BACKGROUND: Escherichia coli (E. coli) is one of the most relevant opportunistic pathogenic bacteria as it may cause severe morbidity and mortality in yaks (poephagus grunniens). In recent years, several kinds of antibiotics have been widely used in Tibetan areas to treat the bacterial diseases, resulting in serious repercussions on the bacterial antibiotic resistance in yaks. This investigation was conducted in order to determine the prevalence of antimicrobial resistance and integron gene cassettes in E...
September 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28885898/antibiotic-prescribing-practices-for-prevention-of-surgical-site-infections-in-australia-increased-uptake-of-national-guidelines-after-surveillance-and-reporting-and-impact-on-infection-rates
#15
Ann L Bull, Leon J Worth, Tim Spelman, Michael J Richards
BACKGROUND: Antimicrobial prophylaxis is the single most effective intervention to reduce risk of surgical site infections (SSIs); however, prescribing practices should be aligned with accepted and recommended surgical antibiotic prophylaxis (SAP) regimens to be effective. As part of a comprehensive surveillance network, SAP data are collated and analyzed for compliance with recommendations. Results are reported to hospitals for quality improvement purposes. In this study, statewide results were analyzed to ascertain changes over time and whether improved compliance was associated with a reduction in risk for SSI...
September 8, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28883972/molecular-characterization-and-antibiotic-resistance-profiles-of-salmonella-isolated-from-fecal-matter-of-domestic-animals-and-animal-products-in-nairobi
#16
Diana Nyabundi, Nyamongo Onkoba, Rinter Kimathi, Atunga Nyachieo, Gerald Juma, Peter Kinyanjui, Joseph Kamau
BACKGROUND: Salmonella has significant public health implications causing food borne and zoonotic diseases in humans. Treatment of infections due to Salmonella is becoming difficult due to emergence of drug resistant strains. There is therefore need to characterize the circulating non-typhoidal Salmonella (NTS) serovars in domestic animals and animal products in Kenya as well as determine their antibiotic resistance profiles. METHODS: A total of 740 fecal samples were collected from cows (n = 150), pigs (n = 182), chicken (n = 191) and chicken eggs (n = 217) from various markets and abattoirs in Nairobi...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/28878891/epidemic-characterization-and-molecular-genotyping-of-shigella-flexneri-isolated-from-calves-with-diarrhea-in-northwest-china
#17
Zhen Zhu, Mingze Cao, Xuzheng Zhou, Bing Li, Jiyu Zhang
BACKGROUND: The widespread presence of antibiotics resistance genes in pathogenic bacteria can cause enormous problems. Food animals are one of the main reservoirs of intestinal pathogens that pose a potential risk to human. Analyzing the epidemiological characteristics and resistance patterns of Shigella flexneri in calves is necessary for animal and human health. METHODS AND RESULTS: A total of 54 Shigella flexneri isolates, including six serotypes (1a, 2a, 2b, 4a, 6 and Xv), were collected from 837 fecal samples obtained from 2014 to 2016...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28874344/using-information-technology-to-improve-surveillance-of-antimicrobial-resistance-in-south-east-asia
#18
Sirenda Vong, Amaury Anciaux, Anette Hulth, John Stelling, Visanu Thamlikitkul, Sunil Gupta, Jonas M Fuks, Kāmini Walia, Pinyo Rattanumpawan, Sergey Eremin, Klara Tisocki, Tika R Sedai, Anuj Sharma
No abstract text is available yet for this article.
September 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28874340/strengthening-laboratory-surveillance-of-antimicrobial-resistance-in-south-east-asia
#19
Aparna Singh Shah, Kumudu Karunaratne, Geeta Shakya, Ismael Barreto, Shashi Khare, Wantana Paveenkittiporn, Sonam Wangchuk, Htay Htay Tin, Milza Abdul Muhsin, Lin Aung, Rajesh Bhatia, Rahul Srivastava, Dwi Adi Maryandi
No abstract text is available yet for this article.
September 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28870265/predicting-multidrug-resistant-gram-negative-bacterial-colonization-and-associated-infection-on-hospital-admission
#20
Wen-Pin Tseng, Yee-Chun Chen, Bey-Jing Yang, Shang-Yu Chen, Jr-Jiun Lin, Ya-Huei Huang, Chia-Ming Fu, Shan-Chwen Chang, Shey-Ying Chen
OBJECTIVE Isolation of multidrug-resistant gram-negative bacteria (MDR-GNB) from patients in the community has been increasingly observed. A prediction model for MDR-GNB colonization and infection risk stratification on hospital admission is needed to improve patient care. METHODS A 2-stage, prospective study was performed with 995 and 998 emergency department patients enrolled, respectively. MDR-GNB colonization was defined as isolates resistant to 3 or more classes of antibiotics, identified in either the surveillance or early (≤48 hours) clinical cultures...
October 2017: Infection Control and Hospital Epidemiology
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