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Skin and soft tissue infection

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https://www.readbyqxmd.com/read/28650945/treatment-approach-for-infection-of-healed-fractures-after-internal-fixation
#1
Joshua M Lawrenz, Salvatore J Frangiamore, Ajinkya A Rane, W Alex Cantrell, Heather A Vallier
OBJECTIVE: To review the efficacy of a treatment approach for patients with infection and colonized implants after open reduction and internal fixation of fractures. DESIGN: Retrospective case series. SETTING: Level one trauma center. PATIENTS: Twenty patients were treated for wound infection with colonized implants after open reduction and internal fixation. INTERVENTION: Surgical debridement, removal of implants and a short post-operative oral antibiotic course...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28646953/nontuberculous-mycobacterial-disease-in-childhood-update-on-diagnostic-approaches-and-treatment
#2
Petra Zimmermann, Nigel Curtis, Marc Tebruegge
Recent studies suggest that the incidence of nontuberculous mycobacterial infections in children may be increasing. Nontuberculous mycobacterial lymphadenitis, skin and soft tissue infection, and pulmonary disease each present unique challenges in relation to diagnosis and treatment. In this update, we critically review the recent literature on the epidemiology, clinical features, diagnostic approaches and treatment of nontuberculous mycobacterial disease in children. In addition, we outline key areas warranting further research...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28646389/photodynamic-therapy-controls-of-staphylococcus-aureus-intradermal-infection-in-mice
#3
Palloma Porto Almeida, Ítalo Sousa Pereira, Karine Bitencourt Rodrigues, Lorena Santos Leal, Andressa Souza Marques, Luciano Pereira Rosa, Francine Cristina da Silva, Robson Amaro Augusto da Silva
Infections caused by Staphylococcus aureus lead to skin infections, as well as soft tissues and bone infections. Given the communal resistance to antibiotics developed by strains of this bacterium, photodynamic therapy emerges as a promising alternative treatment to control and cure infections. Females of the Balb/C mice were infected with 10(8) CFU of methicillin-resistant S. aureus (MRSA) and divided into four distinct groups: P-L- (negative control group), P+L- (group exposed only to curcumin), P-L+ (group exposed only to LED incidence of 450 nm, 75 mW/cm(2), and 54 J/cm(2) for 10 min), and P+L+ (group exposed to curcumin followed by 10 min of LED irradiation) (n = 24)...
June 23, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28645883/the-first-nationwide-surveillance-of-antibacterial-susceptibility-patterns-of-pathogens-isolated-from-skin-and-soft-tissue-infections-in-dermatology-departments-in-japan
#4
Shinichi Watanabe, Takamitsu Ohnishi, Akira Yuasa, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Akira Watanabe, Junko Sato, Hideaki Hanaki, Motomu Manabe, Tamio Suzuki, Fujio Otsuka, Michiko Aihara, Ken Iozumi, Takeshi Tamaki, Yuichi Funada, Mikio Shinozaki, Motoko Kobayashi, Masaru Okuda, Go Kikyo, Kumi Kikuchi, Yoshitane Okada, Masanori Takeshima, Osamu Kaneko, Natsuki Ogawa, Rie Ito, Ryuhei Okuyama, Shinji Shimada, Tadamichi Shimizu, Naohito Hatta, Maeda Manabu, Kiyohiro Tsutsui, Toshihiro Tanaka, Yoshiki Miyachi, Hideo Asada, Fukumi Furukawa, Ichiro Kurokawa, Keiji Iwatsuki, Michihiro Hide, Masahiko Muto, Osamu Yamamoto, Hiroyuki Niihara, Kenji Takagaki, Yasuo Kubota, Koji Sayama, Shigetoshi Sano, Masutaka Furue, Takuro Kanekura
To investigate the trends of antimicrobial resistance in pathogens isolated from skin and soft-tissue infections (SSTI) at dermatology departments in Japan, a Japanese surveillance committee conducted the first nationwide survey in 2013. Three main organisms were collected from SSTI at 30 dermatology departments in medical centers and 10 dermatology clinics. A total of 860 strains - 579 of Staphylococcus aureus, 240 of coagulase-negative Staphylococci, and 41 of Streptococcus pyogenes - were collected and shipped to a central laboratory for antimicrobial susceptibility testing...
June 20, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28642756/high-prevalence-of-macrolide-resistance-and-molecular-characterization-of-streptococcus-pyogenes-isolates-circulating-in-china-from-2009-to-2016
#5
Binghuai Lu, Yujie Fang, Yanyan Fan, Xingchun Chen, Junrui Wang, Ji Zeng, Yi Li, Zhijun Zhang, Lei Huang, Hongxia Li, Dong Li, Fengxia Zhu, Yanchao Cui, Duochun Wang
Streptococcus pyogenes, or group A Streptococcus, is a pathogen responsible for a wide range of clinical manifestations, from mild skin and soft tissue infections and pharyngitis to severe diseases. Its epidemiological characteristics should be comprehensively under surveillance for regulating the national prevention and treatment practice. Herein, a total of 140 S. pyogenes, including 38 invasive and 102 noninvasive isolates, were collected from infected patients in 10 tertiary general hospitals from 7 cities/provinces in China during the years 2009-2016...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28642751/in-vitro-antimicrobial-activity-of-chlorquinaldol-against-microorganisms-responsible-for-skin-and-soft-tissue-infections-comparative-evaluation-with-gentamicin-and-fusidic-acid
#6
Monica Bortolin, Alessandro Bidossi, Elena De Vecchi, Maura Avveniente, Lorenzo Drago
Skin and soft tissue infections (SSTIs) are a major therapeutic challenge for clinicians. The emergence of pathogens with decreased susceptibility to available therapies has become an emerging problem often associated with treatment failure. Hence, there is an urgent need for novel broad-spectrum antimicrobial agents. The purpose of this study was to assess the feasibility of chlorquinaldol as an alternative approach to currently used topical antibiotics for the treatment of skin and soft tissue infections...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28637274/association-of-bariatric-surgery-with-risk-of-infectious-diseases-a-self-controlled-case-series-analysis
#7
Tadahiro Goto, Atsushi Hirayama, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
Background: Although emerging data demonstrate that obesity is a risk factor for infectious diseases, no study has investigated the relationship of bariatric surgery with the risk of infectious diseases among obese adults. Methods: We conducted a self-controlled case series analysis using data from the State Emergency Department Database and State Inpatient Database of three US states (California, Florida, and Nebraska) from 2005 through 2011. We included obese adults who underwent bariatric surgery as an instrument of weight reduction...
June 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28636124/the-ips-scale-a-new-soft-tissue-assessment-scale-for-percutaneous-and-transcutaneous-implants-for-bone-conduction-devices
#8
Ivo J Kruyt, Rik C Nelissen, Martin L Johansson, Emmanuel A M Mylanus, Myrthe K S Hol
Percutaneous titanium implants for bone conduction devices (BCDs) have offered, since 1977, a solution for patients with hearing loss not treatable by conventional hearing aids, such as patients with chronic ear infections or microtia and/or ear canal atresia. Percutaneous implants imply a continuous breach in the mechanical defensive barrier of the skin. To compensate for this breach, immunological mechanisms in the subcutaneous tissue surrounding the implant become more active. This article is protected by copyright...
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28634536/telavancin-a-novel-semisynthetic-lipoglycopeptide-agent-to-counter-the-challenge-of-resistant-gram-positive-pathogens
#9
REVIEW
Biswadeep Das, Chayna Sarkar, Debasmita Das, Amit Gupta, Arnav Kalra, Shubham Sahni
Telavancin (TD-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration (USFDA) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria, including MRSA (S. aureus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus anginosus group, or Enterococcus faecalis)...
March 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28633785/the-lisfranc-amputation-a-more-reliable-level-of-amputation-with-proper-intraoperative-tendon-balancing
#10
Christopher J Greene, Christopher Bibbo
Traditional transmetatarsal amputations are a reliable level of amputation. However, amputations at the Lisfranc level have met with limited success owing to improper biomechanics resulting from tendon imbalance, ultimately leading to foot deformity positions and an unstable soft tissue envelope with ensuing skin breakdown, infection, and below-the-knee amputation. We describe proper tendon rebalancing that results in improved biomechanics and a more reliable and stable amputation at the more proximal Lisfranc level...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28629753/active-identification-of-patients-who-are-methicillin-resistant-staphylococcus-aureus-colonized-is-not-associated-with-longer-duration-of-vancomycin-therapy
#11
Carlos Acuna-Villaorduna, Westyn Branch-Elliman, Judith Strymish, Kalpana Gupta
BACKGROUND: Excessive prescribing of vancomycin among patients admitted to inpatient wards is a challenge for antimicrobial stewardship programs, especially in the setting of expanded screening programs for methicillin-resistant Staphylococcus aureus (MRSA). Studies examining factors associated with longer duration of vancomycin use are limited. METHODS: We conducted a retrospective cohort study to assess the impact of universal MRSA admission screening on duration of vancomycin use at the VA Boston Healthcare System during the period from January 2013-November 2015...
June 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28629484/outbreak-of-non-tuberculous-mycobacteria-skin-or-soft-tissue-infections-associated-with-handling-fish-new-york-city-2013-2014
#12
K Yacisin, J L Hsieh, D Weiss, J Ackelsberg, E Lee, L Jones, Y L Leung, L Li, J Yung, S Slavinski, H Hanson, A Ridpath, J Kornblum, Y Lin, S Robbe-Austerman, J Rakeman, U Siemetzki-Kapoor, T Stuber, S K Greene
Mycobacterium marinum, a bacterium found in freshwater and saltwater, can infect persons with direct exposure to fish or aquariums. During December 2013, the New York City Department of Health and Mental Hygiene learned of four suspected or confirmed M. marinum skin or soft tissue infections (SSTIs) among persons who purchased whole fish from Chinese markets. Ninety-eight case-patients with non-tuberculous mycobacteria (NTM) SSTIs were identified with onset June 2013-March 2014. Of these, 77 (79%) were female...
June 20, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28628457/clonal-clusters-and-virulence-factors-of-group-c-and-g-streptococcus-causing-severe-infections-manitoba-canada-2012-2014
#13
Sylvain A Lother, Walter Demczuk, Irene Martin, Michael Mulvey, Brenden Dufault, Philippe Lagacé-Wiens, Yoav Keynan
The incidence of group C and G Streptococcus (GCGS) bacteremia, which is associated with severe disease and death, is increasing. We characterized clinical features, outcomes, and genetic determinants of GCGS bacteremia for 89 patients in Winnipeg, Manitoba, Canada, who had GCGS bacteremia during 2012-2014. Of the 89 patients, 51% had bacteremia from skin and soft tissue, 70% had severe disease features, and 20% died. Whole-genome sequencing analysis was performed on isolates derived from 89 blood samples and 33 respiratory sample controls: 5 closely related genetic lineages were identified as being more likely to cause invasive disease than non-clade isolates (83% vs...
July 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28627952/clinical-efficacy-of-piperacillin-tazobactam-in-the-treatment-of-complicated-skin-and-soft-tissue-infections
#14
Kohei Takimoto, Qianzhi Wang, Daisuke Suzuki, Mitsuya Katayama, Yoshiro Hayashi
Complicated skin and soft tissue infections (cSSTIs) are skin and soft tissue infections (SSTIs) that involve deep soft tissue. cSSTIs often require surgical intervention and/or hospitalization. cSSTIs are associated with significant mortality and morbidity, and carry a significant burden on health care systems. Piperacillin/tazobactam has been regarded as a standard treatment for cSSTIs because of its antibiotic spectrum, safety and clinical efficacy. Several antibiotics, as compared to piperacillin/tazobactam, have been evaluated in the treatment of cSSTIs...
July 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28615689/nomogram-model-to-predict-postoperative-infection-after-mandibular-osteoradionecrosis-surgery
#15
Zhonglong Liu, Tianguo Dai, Zhonghe Wang, Zhiyuan Zhang, Weiliu Qiu, Yue He
Osteoradionecrosis of the mandible (ORNM) is one of the most dreaded complications of radiotherapy. The poor healing capacity of soft tissue after radiation may lead to surgical failure. The current study was designed to identify prognostic factors for postoperative infection (PPI) and propose corresponding prophylaxis and intervention protocols. A retrospective study was conducted concerning ORNM patients from 2000 to 2015. A risk-stratification score and nomogram model were established to predict the risk of PPI...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615467/evaluation-of-the-bd-max%C3%A2-staphsr-assay-for-detecting-mrsa-and-mssa-in-eswab-collected-wound-samples
#16
Suzane Silbert, Alicia Gostnell, Carly Kubasek, Raymond Widen
Staphylococcus aureus (SA) is the most common pathogen involved in skin and soft tissue infections and it is the principal cause of surgical site infections (1, 2, 3).….
June 14, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28614442/skin-and-soft-tissue-infections-in-the-intensive-care-unit-a-retrospective-study-in-a-tertiary-care-center
#17
Luís Filipe Malheiro, Rita Magano, Alcina Ferreira, António Sarmento, Lurdes Santos
Objective: To identify factors that may influence outcomes in patients with severe skin and soft tissue infections in the intensive care unit. Methods: A retrospective observational study was conducted in a cohort of 1,123 critically ill patients admitted to an intensive care unit with a primary or secondary diagnosis of severe skin and soft tissues infection between January 2006 and December 2014. Results: Thirty patients were included, 20 (66...
June 12, 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28611631/successful-treatment-of-chronic-staphylococcus-aureus-related-dermatoses-with-the-topical-endolysin-staphefekt-sa-100-a-report-of-3-cases
#18
Joan E E Totté, Martijn B van Doorn, Suzanne G M A Pasmans
Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent S. aureus-related dermatoses were successfully treated with Staphefekt SA.100. Staphefekt SA.100 is a recombinant phage endolysin for topical skin application that specifically targets both methicillin-sensitive and methicillin-resistant S...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28608660/emergence-of-community-genotype-methicillin-resistant-staphylococcus-aureus-in-korean-hospitals-clinical-characteristics-of-nosocomial-infections-by-community-genotype-strain
#19
Eun Jeong Joo, Doo Ryeon Chung, So Hyun Kim, Jin Yang Baek, Nam Yong Lee, Sun Young Cho, Young Eun Ha, Cheol In Kang, Kyong Ran Peck, Jae Hoon Song
BACKGROUND: As community-genotype methicillin-resistant Staphylococcus aureus (MRSA) strains spread into hospitals, the genotypes of the MRSA strains causing hospital-acquired (HA) infections have become more diverse. We describe clinical characteristics of nosocomial MRSA infections by a community-genotype of sequence type (ST) 72. MATERIALS AND METHODS: A case-control study was designed among patients with HA-MRSA infections. Forty patients with infections caused by ST72-MRSA SCCmec type IV were selected as cases...
May 26, 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/28607014/np108-an-antimicrobial-polymer-with-activity-against-methicillin-and-mupirocin-resistant-staphylococcus-aureus
#20
Derry K Mercer, Laura K Katvars, Fiona Hewitt, Daniel W Smith, Jennifer Robertson, Deborah A O'Neil
Staphylococcus aureus is a clinically significant human pathogen that causes infectious diseases ranging from skin and soft tissue infections (SSTI), healthcare associated infections (HAI) to potentially fatal bacteraemia and endocarditis. Nasal carriage of S. aureus, especially persistent carriage, is associated with an increased risk of subsequent infection, particularly nosocomial and surgical site infections (SSI), usually via autoinfection. NP108 is a cationic antimicrobial polymer composed of Generally Recognized as Safe (GRAS) amino acid building blocks...
June 12, 2017: Antimicrobial Agents and Chemotherapy
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