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Skin and soft tissue infection

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https://www.readbyqxmd.com/read/29667186/infectious-diseases-in-older-adults-of-long-term-care-facilities-update-on-approach-to-diagnosis-and-management
#1
REVIEW
Robin L P Jump, Christopher J Crnich, Lona Mody, Suzanne F Bradley, Lindsay E Nicolle, Thomas T Yoshikawa
The diagnosis, treatment, and prevention of infectious diseases in older adults in long-term care facilities (LTCFs), particularly nursing facilities, remains a challenge for all health providers who care for this population. This review provides updated information on the currently most important challenges of infectious diseases in LTCFs. With the increasing prescribing of antibiotics in older adults, particularly in LTCFs, the topic of antibiotic stewardship is presented in this review. Following this discussion, salient points on clinical relevance, clinical presentation, diagnostic approach, therapy, and prevention are discussed for skin and soft tissue infections, infectious diarrhea (Clostridium difficile and norovirus infections), bacterial pneumonia, and urinary tract infection, as well as some of the newer approaches to preventive interventions in the LTCF setting...
April 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29667040/management-of-superficial-and-deep-seated-staphylococcus-aureus-skin-and-soft-tissue-infections-in-sub-saharan-africa-a-post-hoc-analysis-of-the-staphnet-cohort
#2
Abraham Alabi, Theckla Kazimoto, Marthe Lebughe, Delfino Vubil, Patrick Phaku, Inacio Mandomando, Winfried V Kern, Salim Abdulla, Alexander Mellmann, Lena Peitzmann, Markus Bischoff, Georg Peters, Mathias Herrmann, Martin P Grobusch, Frieder Schaumburg, Siegbert Rieg
PURPOSE: The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in the African setting and to identify challenges in the management. METHODS: Patients (n = 319) were recruited in DR Congo (n = 56, 17.6%), Gabon (n = 89, 27...
April 17, 2018: Infection
https://www.readbyqxmd.com/read/29661109/prevalence-and-risk-factors-for-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-custodial-populations-a-systematic-review
#3
Leigh Haysom, Melanie Cross, Rebecca Anastasas, Elizabeth Moore, Stephen Hampton
Methicillin-resistant Staphylococcus aureus (MRSA) in prisons can result in serious morbidity and death. We reviewed rates and risk factors for MRSA infection in custody, searching Medline, EMBASE, and CINAHL databases. Between 1997 and 2015, 17 studies reported MRSA skin and soft tissue infections (SSTIs), with four case reports of MRSA non-SSTI (necrotizing pneumonias, brain abscess, and epiduritis). Significant associations with MRSA SSTI were found: MRSA colonization, previous skin infection, sharing soap or personal items, SSTI presenting as an abscess or furuncle, younger age, non-Caucasian, overweight, communal laundering, infrequent handwashing, lower hygiene score...
April 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29659771/infectious-complications-after-deployment-trauma-following-wounded-united-states-military-personnel-into-veterans-affairs-care
#4
Jay R McDonald, Stephen Y Liang, Ping Li, Salwa Maalouf, Clinton K Murray, Amy C Weintrob, Elizabeth R Schnaubelt, Janis Kuhn, Anuradha Ganesan, William Bradley, David R Tribble
Background: Infectious complications related to deployment trauma significantly contribute to the morbidity and mortality impacting wounded service members. The Trauma Infectious Disease Outcomes Study (TIDOS) collects data on U.S. military personnel injured in Iraq and Afghanistan in an observational cohort study of infectious complications. Patients enrolled in TIDOS may also consent to follow-up through the Department of Veterans Affairs (VA). We present data from the first 337 TIDOS enrollees to receive VA healthcare...
April 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29657725/adherence-rate-of-quality-of-care-indicators-for-staphylococcus-aureus-bacteremia-is-extremely-low-in-japanese-emergency-and-critical-care-departments-a-multicenter-retrospective-observational-study
#5
Kyohei Miyamoto, Seiya Kato, Junichi Kitayama, Junpei Okawa, Ayana Okamoto, Jun Kamei, Kazuhisa Yoshiya, Hideki Asai, Shingo Adachi, Hidekazu Yukioka, Hiroshi Akimoto, Kazuo Okuchi
Aim: Staphylococcus aureus bacteremia causes significant morbidity and mortality and requires specific management to prevent complications. Most studies evaluating quality of care have been carried out in Europe and North America, and accurate epidemiological data are lacking in Asia. We aimed to describe the epidemiology and evaluate the quality of care for S. aureus bacteremia in Japan. Methods: From February 2011 to January 2014, we undertook a multicenter retrospective observational study in 10 departments of emergency and critical care in Japan...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29652296/validation-of-the-aast-egs-grade-for-skin-and-soft-tissue-infection
#6
Mohamed D Ray-Zack, Matthew C Hernandez, Moustafa Younis, Wyatt B Hoch, Dylan S Soukup, Nadeem Haddad, Martin D Zielinski
INTRODUCTION: Skin and soft tissue infections (SSTI) present with variable severity. The American Association for the Surgery of Trauma (AAST) developed an emergency general surgery (EGS) grading system for several diseases. We aimed to determine whether the AAST EGS grade corresponds with key clinical outcomes. METHODS: Single institution retrospective review of patients (≥18 years) admitted with SSTI during 2012-2016 was performed. Patients with surgical site infections or <18 years were excluded...
February 27, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29650464/clioquinol-an-alternative-antimicrobial-agent-against-common-pathogenic-microbe
#7
Z You, X Ran, Y Dai, Y Ran
Skin and soft tissue infections (SSTIs) are very common in dermatology and the use of antimicrobial formulations are important in treating these diseases. With the increasing of drug-resistant strains, researchers need to find ways to enhance the effectiveness and/or reduce the drug resistance. Clioquinol was one of antiseptics that can inactivate microbes. It was lack of data of antimicrobial activity; meanwhile it was infrequently used in infection. In order to research the antimicrobial spectrum and activity of topical 3% clioquinol cream among common pathogenic microorganisms compared with other common topical pharmaceuticals, we used modified agar diffusion assay to judge drug susceptibility and compared with broth microdilution assay...
April 10, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29644315/limb-salvage-and-reconstruction-following-a-zebra-attack
#8
Jacob T Carlson, James C Yuen, Matthew R Smeds
Animal bites are fairly rare events but can cause devastating traumatic injuries to the victim. In addition to the soft tissue, vascular, and orthopedic trauma inflicted by these occurrences, bite injuries also have the potential to introduce an inoculum of microbes, which may progress to an infection if not treated properly and expeditiously. We present the case of a healthy male who sustained multiple bite wounds from a domestic zebra to his left upper extremity. This attack caused severe damage, including devascularization of the arm at the brachial artery, disruption of the distal biceps and brachialis, stripping of the forearm nerves, and shearing of the overlying soft tissue...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29643807/antimicrobial-peptides-and-their-therapeutic-potential-for-bacterial-skin-infections-and-wounds
#9
REVIEW
Anja Pfalzgraff, Klaus Brandenburg, Günther Weindl
Alarming data about increasing resistance to conventional antibiotics are reported, while at the same time the development of new antibiotics is stagnating. Skin and soft tissue infections (SSTIs) are mainly caused by the so called ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter species) which belong to the most recalcitrant bacteria and are resistant to almost all common antibiotics. S. aureus and P. aeruginosa are the most frequent pathogens isolated from chronic wounds and increasing resistance to topical antibiotics has become a major issue...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29627916/necrotizing-fasciitis-case-series-and-review-of-the-literature-on-clinical-and-medico-legal-diagnostic-challenges
#10
Paolo Fais, Alessia Viero, Guido Viel, Renzo Giordano, Dario Raniero, Stefano Kusstatscher, Chiara Giraudo, Giovanni Cecchetto, Massimo Montisci
Necrotizing fasciitis (NF) is a life-threatening infection of soft tissues spreading along the fasciae to the surrounding musculature, subcutaneous fat and overlying skin areas that can rapidly lead to septic shock and death. Due to the pandemic increase of medical malpractice lawsuits, above all in Western countries, the forensic pathologist is frequently asked to investigate post-mortem cases of NF in order to determine the cause of death and to identify any related negligence and/or medical error. Herein, we review the medical literature dealing with cases of NF in a post-mortem setting, present a case series of seven NF fatalities and discuss the main ante-mortem and post-mortem diagnostic challenges of both clinical and forensic interests...
April 7, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29626746/experiences-with-skin-and-soft-tissue-infections-among-people-who-inject-drugs-in-philadelphia-a-qualitative-study
#11
Robert E Harris, Jessica Richardson, Rosemary Frasso, Evan D Anderson
OBJECTIVES: To understand how people who inject drugs (PWID) experience skin and soft tissue infections (SSTI) and make decisions to seek or delay medical treatment. METHODS: We conducted semi-structured, in-depth interviews in 2015 with 19 PWID at a syringe exchange program in Philadelphia. We analyzed the data using standard qualitative techniques. RESULTS: PWID described adequate knowledge about SSTI, although they could not always implement knowledge about SSTI prevention due to environmental constraints...
March 23, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29623211/-shewanella-spp-infections-in-gran-canaria-spain-retrospective-analysis-of-31-cases-and-a-literature-review
#12
Alberto J Martín-Rodríguez, Oriol Martín-Pujol, Fernando Artiles-Campelo, Margarita Bolaños-Rivero, Ute Römling
Introduction: Shewanella spp. can cause severe skin and soft-tissue infections, gastrointestinal infections, otitis and bacteraemia, generally upon contact with seawater or consumption of raw seafood. Recently, a new condition termed 'patera foot' characterized by acute skin and soft-tissue infection has been described in irregular immigrants arriving to the Canary Islands, Spain, in rudimentary boats. Most infections are caused by a single species, Shewanella algae . The improvement of the diagnostic capabilities in clinical microbiology laboratories has resulted in a growing number of cases being reported worldwide, most of them coming from warm regions...
December 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29621601/results-from-the-third-scottish-national-prevalence-survey-is-a-population-health-approach-now-needed-to-prevent-hai
#13
Shona Cairns, Cheryl Gibbons, Aynsley Milne, Hazel King, Melissa Llano, Laura MacDonald, William Malcolm, Chris Robertson, Jacqueline Sneddon, Jennifer Weir, Jacqui Reilly
BACKGROUND: Healthcare associated infections (HAI) are a major public health concern and a significant cause of morbidity and mortality. A robust and current evidence base that is specific to local, national and Europe-wide settings is necessary to inform the development of strategies to reduce HAI and contain antimicrobial resistance (AMR). AIM: To measure the prevalence of HAI and antimicrobial prescribing and identify key priority areas for interventions to reduce the burden of infection...
April 2, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29617742/a-statewide-antibiotic-stewardship-collaborative-to-improve-the-diagnosis-and-treatment-of-urinary-tract-and-skin-and-soft-tissue-infections
#14
Timothy C Jenkins, Teresa Hulett, Bryan C Knepper, Katherine C Shihadeh, Marc J Meyer, Gerard R Barber, John H Hammer, Heidi L Wald
Background: Colorado hospitals participated in a statewide collaborative to improve the diagnosis and treatment of inpatient urinary tract infections (UTI) and skin and soft tissue infections (SSTI). We evaluated the effects of the intervention on diagnostic accuracy and antibiotic use. Methods: The collaborative outcomes were: (1) proportion of UTI diagnoses meeting criteria for symptomatic UTI; (2) exposure to fluoroquinolones (UTI only); (3) duration of therapy (UTI and SSTI); and (4) exposure to antibiotics with broad gram-negative activity (SSTI only)...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29606562/evaluation-of-postoperative-changes-in-vascularized-iliac-bone-grafts-used-for-mandibular-reconstruction
#15
T Noguchi, S Sarukawa, Y Tsuchiya, N Okada, J Hayasaka, K Sasaguri, H Nishino, Y Jinbu, Y Mori
Vascularized iliac bone grafts are used for mandibular reconstruction, but the factors affecting graft maintenance are unknown. This study explored the postsurgical changes in vascularized iliac bone grafts in patients who had undergone mandibular reconstruction after segmental resection. The study involved 24 patients (16 men and eight women) with oral tumours or osteoradionecrosis. Thirteen patients required bare bone grafting (BBG) and 11 patients required reconstruction with soft tissue coverage (six with a skin paddle and five with direct closure)...
March 29, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29600669/-clinical-effect-modified-chevron-osteotomy-combined-with-lateral-tissue-loosening-in-treating-mild-moderate-hallux-valgus-through-internal-signal-approach
#16
Xue-Qiang Chen, Qun-Feng Wu, Wei-Qin Dong, Li-Xin Yu, Xiong-Feng Li
OBJECTIVE: To explore clinical effect of modified Chevron osteotomy combined with lateral tissue loosening for the treatment of mild-moderate hallux valgus through internal signal approach. METHODS: From July 2015 to June 2016, 26 patients with mild-moderate hallux valgus treated with modified Chevron osteotomy combined with lateral tissue loosening through internal signal approach, including 2 males and 24 females aged from 45 to 65 years old with an average of(54...
March 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29596507/comparison-of-the-immune-response-during-acute-and-chronic-staphylococcus-aureus-infection
#17
Rebecca A Brady, Christopher P Mocca, Roger D Plaut, Kazuyo Takeda, Drusilla L Burns
Staphylococcus aureus bacteria are able to grow in a planktonic state that is associated with acute infections and in biofilms that are associated with chronic infections. Acute infections, such as skin infections, are often self-limiting. However, chronic infections, such as implant infections, can be difficult to clear and may require surgical intervention. The host immune response may contribute to the different outcomes often associated with these two disease types. We used proteomic arrays and two murine models for an initial, descriptive characterization of the contribution of the host immune response to outcomes of acute versus chronic S...
2018: PloS One
https://www.readbyqxmd.com/read/29596040/comparative-study-of-drainage-and-antibiotics-versus-drainage-only-in-the-management-of-primary-subcutaneous-abscesses
#18
Julio López, Gilberto Gómez, Karime Rodriguez, Julio Dávila, José Núñez, Luis Anaya
BACKGROUND: Skin and soft tissue infections are common problems dealt with in emergency departments and medical offices. It is routine practice to prescribe antibiotic agents after incision and drainage of cutaneous abscesses. However, current evidence does not support prescribing oral antibiotic agents after surgical debridement. The aim of the present study was to determine the actual role of antibiotic agents after drainage of cutaneous abscesses. PATIENTS AND METHODS: This was a prospective study of patients undergoing incision and drainage (I&D) of a subcutaneous abscess...
April 2018: Surgical Infections
https://www.readbyqxmd.com/read/29595103/application-of-medicinal-plants-as-a-source-for-therapeutic-agents-against-streptococcus-pyogenes-infections
#19
Adil Mohd, H P Vasantha Rupasinghe
Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis. This Gram-positive bacterium has an ability to form mature biofilm and this sessile lifestyle plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence...
March 29, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29593878/methicillin-resistant-staphylococcus-aureus-prostatic-abscess-after-traumatic-rectal-injury
#20
Joud Jarrah, Varun Samji, Meron Meshesha, Chandrasekhar Kothuru, Samer Al Hadidi
Methicillin-resistant Staphylococcus aureus (MRSA) commonly causes infection of the skin, soft tissue, bones and heart. MRSA is a rarely reported organism of prostatic abscess (PA). We present a case of an intravenous drug user who presented with dyspareunia, dysuria and dyschezia after a traumatic injury to the rectum. He was diagnosed with PA, which was treated with transurethral resection of the prostate drainage and intravenous antibiotics. MRSA PA carries a low case fatality rate on early diagnosis and treatment with proper antibiotics with or without drainage of the abscess...
March 2018: Oxford Medical Case Reports
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