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Skin and soft tissue infection

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https://www.readbyqxmd.com/read/29026866/a-prospective-observational-study-of-the-epidemiology-management-and-outcomes-of-skin-and-soft-tissue-infections-due-to-carbapenem-resistant-enterobacteriaceae
#1
Oryan Henig, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, Keith S Kaye
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29026630/sinister-seafood-bacteraemia-secondary-to-non-o1-o139-vibrio-cholerae-infection
#2
Maxime J Billick, Philip W Lam, Isaac I Bogoch
Introduction.Vibrio species are curved, motile Gram-negative bacilli found in estuarine and marine environments, and are known to cause to gastroenteritis, skin and soft tissue infections, and septicaemia. While not responsible for cholera epidemics, non-O1/O139 Vibrio cholerae (NOVC) is increasingly reported as a cause of gastroenteritis. Case presentation. A 66-year-old man presented to an emergency department with a 1 week history of epigastric pain, emesis and fever. Blood cultures drawn on admission initially demonstrated Gram-negative bacilli, and ultimately grew NOVC, which was later confirmed by matrix-assisted laser desorption ionization-time of flight MS...
July 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29025616/the-peroneus-brevis-flap-in-the-treatment-of-bone-infections-of-the-lower-limb
#3
Andrea Antonini, Carlo Rossello, Carlo Salomone, Giovanni Riccio, Lamberto Felli, Giorgio Burastero
The Peroneus Brevis Flap is a described option for the soft tissue coverage and for small bone gap reconstruction in the lower third of the lower leg, where few other local flaps are available and reliable. We analysed retrospectively a case series of 11 consecutive patients whose age ranged from 31 to 87 years (mean 56), who underwent a reconstruction with a PB flap in the treatment of post-traumatic bone infections from October 2010 to February 2012. In our series, only one patient at a 3 year minimum follow-up showed recurrence of the bone infection and required further surgical treatment...
October 2017: Injury
https://www.readbyqxmd.com/read/29022273/staphylococcus-lugdunensis-infections-of-the-skin-and-soft-tissue-a-case-series-and-review
#4
Lucas A Heldt Manica, Philip R Cohen
INTRODUCTION: Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the characteristics of other patients that were previously described with this organism as the causative agent of skin infection...
October 11, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29020322/trends-in-methicillin-resistant-staphylococcus-aureus-hospitalizations-in-the-united-states-2010-2014
#5
Eili Y Klein, Nestor Mojica, Wendi Jiang, Sara E Cosgrove, Edward Septimus, Daniel J Morgan, Ramanan Laxminarayan
Reports have suggested declines in incidence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. Our analysis of data from the National Inpatient Sample shows that the decrease in MRSA-related hospitalizations between 2010 and 2014 was primarily due to declines in skin- and soft-tissue infections. Invasive MRSA-related hospitalizations remained largely unchanged.
July 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020285/impact-of-systemic-antibiotics-on-staphylococcus-aureus-colonization-and-recurrent-skin-infection
#6
Patrick G Hogan, Marcela Rodriguez, Allison M Spenner, Jennifer M Brenneisen, Mary G Boyle, Melanie L Sullivan, Stephanie A Fritz
Background: Staphylococcus aureus colonization poses risk for subsequent skin and soft tissue infection (SSTI). We hypothesized that including systemic antibiotics in the management of S. aureus SSTI, in conjunction with incision and drainage, would reduce S. aureus colonization and incidence of recurrent infection. Methods: We prospectively evaluated 383 children with S. aureus SSTI requiring incision and drainage and S. aureus colonization in the anterior nares, axillae, or inguinal folds at baseline screening...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28990692/functional-results-of-free-tissue-transfer-for-complex-heel-calcaneal-defects
#7
Chang-Yi Chou, Hao-Yu Chiao, Chi-Yu Wang, Yu-Shan Sun, Chin-Ta Lin, Niann-Tzyy Dai, Shyi-Gen Chen, Shun-Cheng Chang
BACKGROUND: Loss of soft tissue in heel-calcaneal region is frequently caused by trauma, infection, or tumors. Limited availability of similar tissue becomes challenging, therefore, the use of free tissue transfer offers a solution. Our aim is to describe long term functional outcome of different free tissue transfers for these defects. PATIENTS AND METHODS: We retrospectively reviewed 24 consecutive cases of the heel-calcaneal defect between January 2009 and December 2014...
October 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28980174/a-24-month-evaluation-of-a-percutaneous-osseointegrated-limb-skin-interface-in-an-ovine-amputation-model
#8
Sujee Jeyapalina, James Peter Beck, Jayant Agarwal, Kent N Bachus
Percutaneous osseointegrated (OI) prostheses directly connect an artificial limb to the residual appendicular skeleton via a permanently implanted endoprosthesis with a bridging connector that protrudes through the skin. The resulting stoma produces unique medical and biological challenges. Previously, a study using a large animal amputation model indicated that infection could be largely prevented, for at least a 12-month period, but the terminal epithelium continued to downgrow. The current study was undertaken to test the longer-term efficacy of this implant construct to maintain a stable skin-implant interface for 24 months...
October 4, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28978607/necrotising-fasciitis-a-ticking-time-bomb
#9
Carlijn H L van Sambeek, Sander F van Stigt, Lars Brouwers, Mike Bemelman
Necrotising fasciitis (NF) is a destructive bacterial infection and has often been described in media reports as a 'flesh-eating disease', which if diagnosed late is associated with worse outcome. Unfortunately, diagnosing NF is difficult due to the similar presentation of NF compared with other types of skin and soft tissue infections. The early presentation of NF only shows tenderness, swelling, erythema and warm skin. Moreover, NF is normally accompanied with aberrant laboratory findings, mainly elevated C reactive protein (CRP) levels...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28978204/a-simple-novel-technique-for-fixing-penrose-drains-in-minor-surgeries-with-advantages-for-remote-outpatient-clinics-a-retrospective-comparison-with-conventional-drain-fixation-in-north-ibaraki-japan
#10
Yoichiro Shibuya, Go Matsumoto, Masahiro Sasaki, Kaoru Sasaki, Koji Adachi, Mitsuru Sekido
INTRODUCTON: In rural areas with few doctors, Penrose drains in minor surgeries for soft tissue trauma or small subcutaneous tumors are sometimes avoided, even though the drain would prevent hematoma, because of the limited availability of professional postsurgical care. The authors developed a simple fixation method for Penrose drains that can be used even in remote areas where a doctor is not present to remove the drain. A retrospective study was conducted to compare this new method of fixing Penrose drains with instances in which the Penrose drain was fixed to skin by conventional suturing...
October 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28971307/non-tuberculous-mycobacterium-bacteraemia-in-a-pregnant-systemic-lupus-erythematosus-sle-patient-a-case-review-and-pooled-case-analysis
#11
REVIEW
Syahrul Sazliyana Shaharir, Narisa Sulaiman Sahari, Zeena Mohamed Fuad, Wan Zul Haikal Wan Zukiman, Nurul Hafizah Mohd Yusof, Anita Sulong, Petrick Periasamy
Non-tuberculous mycobacteria (NTM) are recognized as an important cause of human diseases and infections. It is commonly known to cause infections of the skin, soft tissue infections, and pulmonary infection as well as bacteraemia. We report a challenging case of severe mycobacterium abscessus bacteraemia in a pregnant lady with active systemic lupus erythematous (SLE). A comprehensive literature review of NTM infection among SLE patients was also performed, and pooled analysis of the reported cases, including our case, was done to determine the clinical characteristics and factors associated with poor outcome of NTM infection...
October 3, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28969523/postoperative-feeding-regimens-after-laparoscopic-gastrostomy-placement
#12
Eric H Rosenfeld, Kirea Mazzolini, Annalyn DeMello, Yangyang R Yu, Timothy C Lee, Bindi Naik-Mathuria, Mark V Mazziotti, Sohail R Shah
PURPOSE: The objective of this study was to evaluate postoperative feeding regimens after laparoscopic gastrostomy placement and their effect on outcomes. METHODS: Children 18 years of age or younger, who underwent laparoscopic gastrostomy placement at a tertiary-care academic children's hospital between January 2014 and October 2016, were reviewed. Data collected included patient characteristics, postoperative feeding regimen, and clinical outcomes. Statistical analysis was performed using Chi-square, Fisher's exact, and Wilcoxon Rank-Sum tests...
October 2, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28969128/decline-of-nosocomial-methicillin-resistant-staphylococcus-aureus-skin-and-soft-tissue-infections-in-an-indian-tertiary-hospital-hope-for-the-future
#13
Rojaleen Das, Sujeesh Sebastian, Arti Kapil, Benu Dhawan
No abstract text is available yet for this article.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28959445/management-of-acute-bacterial-skin-and-skin-structure-infections-with-a-focus-on-patients-at-high-risk-of-treatment-failure
#14
REVIEW
Abraham Pulido-Cejudo, Mario Guzmán-Gutierrez, Abel Jalife-Montaño, Alejandro Ortiz-Covarrubias, Jose Luis Martínez-Ordaz, Héctor Faustino Noyola-Villalobos, Luis Mauricio Hurtado-López
Over the last 25 years, the terminology of skin and soft tissue infections, as well as their classification for optimal management of patients, has changed. The so-called and recently introduced term 'acute bacterial skin and skin structure infections' (ABSSSIs), a cluster of fairly common types of infection, including abscesses, cellulitis, and wound infections, require an immediate effective antibacterial treatment as part of a timely and cautious management. The extreme level of resistance globally to many antibiotic drugs in the prevalent causative pathogens, the presence of risk factors of treatment failure, and the high epidemic of comorbidities (e...
September 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28956275/infection-of-recurrent-calcaneal-ulcer-caused-by-a-biofilm-producer-myroides-odoratimimus-strain
#15
Arianna Pompilio, Giuseppe Galardi, Giovanni Gherardi, Fabio Verginelli, Cristina Geminiani, Argenia Paola Pilloni, Piergiorgio Catalanotti, Giovanni Di Bonaventura
We report a case of recurrent post-traumatic ulcer infection due to Myroides odoratimimus in an immunocompromised male. We have also reviewed the medical literature on isolated M. odoratimimus infections. The strain, isolated from ulcer discharge, was multidrug-resistant and treatment with meropenem, based on susceptibility testing, led to resolution of infection. The strain was also able to form a relevant amount of biofilm over time, thus suggesting a possible role of sessile communities in the chronicization of infection...
September 27, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28953638/anti-interferon-%C3%AE-autoantibody-associated-disseminated-mycobacterium-abscessus-infection-mimicking-parotid-cancer-with-multiple-metastases-a-case-report
#16
Po-Hsiung Chang, Yu-Chung Chuang
RATIONALE: Among the nontuberculous mycobacteria, Mycobacterium abscessus is a common cause of skin, soft tissue, and bone infections. However, disseminated M. abscessus infection that mimics cancer metastasis with an underlying relatively immunocompetent condition has rarely been reported. PATIENT CONCERNS: A nonsmoking 73-year-old man with an underlying relatively immunocompetent condition reported a 2-month history of a mass in the region of his right parotid gland that had been steadily increasing in size...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28950196/a-therapeutic-polyelectrolyte-vitamin-c-nanoparticulate-system-in-polyvinyl-alcohol-alginate-hydrogel-an-approach-to-treat-skin-and-soft-tissue-infections-caused-by-staphylococcus-aureus
#17
Liya George, M C Bavya, K Vimal Rohan, R Srivastava
Staphylococcus aureus infections affecting the skin and soft tissues are of significant health concern and an unmet need to be addressed. The lack of drug penetration into the infectious site is the main clinical challenge. Once the pathogen invades the wounded skin, it attenuates biological response pathways, leading to chronic infection. Wound infections are associated with alkaline pH due to the presence of bacteria, whereas creation of an acidic environment around the wound bed promotes faster healing. Herein, we develop injectable drug loaded nanoparticulate system of vancomycin encapsulated polycaprolactone nanoparticles coated with polyelectrolyte-Vitamin C in polyvinyl alcohol-alginate gel (D-PCL-PVc-PVA(Alg)...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28944569/prognostic-factors-and-treatment-outcomes-for-patients-with-fournier-s-gangrene-a-retrospective-study
#18
Kyung Sook Hong, Hee Jung Yi, Ryung-Ah Lee, Kwang Ho Kim, Soon Sup Chung
Fournier's gangrene is a gas-forming, necrotising soft tissue infection affecting the perineum. It spreads rapidly along the deep fascial planes and is associated with a high mortality rate. With a growing elderly population with comorbidities, the frequency of severe cases of Fournier's gangrene is expected to increase. We retrospectively reviewed 20 patients diagnosed with Fournier's gangrene at our institution from 2003 to 2014 and analysed data. Thirteen patients had diabetes mellitus, two had been diagnosed with liver cirrhosis, and four were chronic alcoholics...
September 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28943820/clinical-outcomes-with-continuous-nafcillin-infusions-in-children
#19
Chad A Knoderer, Lauren C Karmire, Kristen R Nichols
OBJECTIVES: The primary objective of this study was to describe the clinical outcomes of continuous nafcillin infusion in pediatric patients. METHODS: This was a retrospective case study performed at a freestanding, tertiary care children's hospital. Subjects were included if they were at least 30 days old and had received more than 1 dose of nafcillin by continuous infusion (CI) between January 1, 2009, and December 31, 2012. Clinical and microbiological data were extracted from the medical record...
July 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28941632/professional-practice-evaluation-of-emergency-department-prescriptions-for-community-acquired-infections-in-lebanon
#20
Iqbal Fahs, Zeina Shrayteh, Rima Abdulkhalek, Pascale Salameh, Souheil Hallit, Diana Malaeb
BACKGROUND: Selecting the appropriate antibiotic regimen is extremely important in improving patient outcomes, minimizing antimicrobial resistance, and reducing costs. This study was conducted to evaluate current prescribing practices for empiric antibiotics at the time of admission to the emergency department (ED) and to assess their appropriateness in Lebanon. METHODS: A retrospective observational study was conducted at three different Lebanese hospitals between June and December 2016...
September 21, 2017: International Journal of Infectious Diseases: IJID
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