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Skin and soft tissue infection

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https://www.readbyqxmd.com/read/29457435/-repair-soft-tissue-defect-in-forefoot-with-reversed-lateral-soleus-muscle-flap
#1
Gong-Lin Zhang, Ping Zhen, Ke-Ming Chen, Lai-Xu Zhao, Jun-Lin Yang, Jan-Hua Zhou, Qin-Yi Xue
OBJECTIVE: To summarize clinical application results of repair soft tissue defect in forefoot with a reversed lateral soleus muscle flap on peroneal artery pedicle. METHODS: From January 2005 to January 2013, 8 patients with soft-tissue defect on forefoot were underwent reconstruction with a reversed lateral soleus muscle flap on peroneal artery pedicle. There were 6 males and 2 female, aged from 16 to 48 years with an average of 26.8 years old. The reversed lateral soleus muscle flap was transposed to the forefoot defect area, then immediate coverage of the muscle flaps were performed by a meshed split-thickness free skin graft...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29453874/outcomes-of-early-dermatology-consultation-for-inpatients-diagnosed-with-cellulitis
#2
David G Li, Fan Di Xia, Hasan Khosravi, Anna K Dewan, Daniel J Pallin, Christopher W Baugh, Karl Laskowski, Cara Joyce, Arash Mostaghimi
Importance: Many inflammatory skin dermatoses mimic cellulitis (pseudocellulitis) and are treated with antibiotics and/or hospitalization, leading to unnecessary patient morbidity and substantial health care spending. Objective: To evaluate the impact of early dermatology consultation on clinical and economic outcomes associated with misdiagnosed cellulitis. Design, Setting, and Participants: This prospective cohort study enrolled patients with presumed diagnosis of cellulitis in the emergency department, in the emergency department observation unit, or within 24 hours of admission to an inpatient unit of a large urban teaching hospital between February and September 2017...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29452993/an-in-vitro-evaluation-of-the-efficacy-of-tedizolid-implications-for-the-treatment-of-skin-and-soft-tissue-infections
#3
Pierre Delpech, Muna ALeryan, Brian Jones, Curtis Gemmell, Sue Lang
Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide. The aetiology is diverse, but Staphylococcus aureus predominate and these are often resistant to antimicrobials that were previously effective. Tedizolid is a new oxazolidinone-class antibacterial indicated for the treatment of adults with SSTI caused by Gram-positive pathogens, including S. aureus. The aim of this study was to evaluate the in vitro efficacy of tedizolid in comparison to other clinically used antibacterials against antibiotic sensitive- and resistant-staphylococci, grown in planktonic cultures and as biofilms reflecting the growth of the microorganism during episodes of SSTI...
January 10, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29452936/use-of-telemedicine-in-the-management-of-infectious-diseases
#4
G Gras
Communication technologies have invaded our daily lives. Several studies have assessed these technologies in the management of infectious diseases (mainly HIV). Weekly short text messages and real-time compliance monitoring assessed in HIV patients are both associated with higher compliance in low-income countries. Virtual consultations to monitor stable chronic HIV patients or tuberculosis treatment in high-income countries appear to be acceptable and efficient. Although assessed in small studies, virtual monitoring seems to reinforce the doctor-patient relationship and the relation between primary care settings and hospitals in various infectious diseases (endocarditis, urinary tract infection, skin and soft tissue infection, HIV, tuberculosis, hepatitis C)...
February 13, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29452598/7-versus-14-days-of-antibiotic-treatment-for-critically-ill-patients-with-bloodstream-infection-a-pilot-randomized-clinical-trial
#5
Nick Daneman, Asgar H Rishu, Ruxandra Pinto, Pierre Aslanian, Sean M Bagshaw, Alex Carignan, Emmanuel Charbonney, Bryan Coburn, Deborah J Cook, Michael E Detsky, Peter Dodek, Richard Hall, Anand Kumar, Francois Lamontagne, Francois Lauzier, John C Marshall, Claudio M Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Wendy Sligl, Henry T Stelfox, M Elizabeth Wilcox, Robert A Fowler
BACKGROUND: Shorter-duration antibiotic treatment is sufficient for a range of bacterial infections, but has not been adequately studied for bloodstream infections. Our systematic review, survey, and observational study indicated equipoise for a trial of 7 versus 14 days of antibiotic treatment for bloodstream infections; a pilot randomized clinical trial (RCT) was a necessary next step to assess feasibility of a larger trial. METHODS: We conducted an open, pilot RCT of antibiotic treatment duration among critically ill patients with bloodstream infection across 11 intensive care units (ICUs)...
February 17, 2018: Trials
https://www.readbyqxmd.com/read/29450214/-mycobacterium-abscessus-complex-infections-a-retrospective-cohort-study
#6
Maroun Sfeir, Marissa Walsh, Rossana Rosa, Laura Aragon, Sze Yan Liu, Timothy Cleary, Marylee Worley, Corey Frederick, Lilian M Abbo
Background: Infections caused by Mycobacterium abscessus group strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. We describe the risk factors, treatment, and clinical outcomes of patients in 2 large academic medical centers in the United States. Methods: A retrospective cohort study of hospitalized adults with a positive culture for M. abscessus in Miami, Florida (January 1, 2011, to December 31, 2014). Demographics, comorbidities, the source of infection, antimicrobial susceptibilities, and clinical outcomes were analyzed...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29447384/antimicrobial-prophylaxis-with-combat-related-open-soft-tissue-injuries
#7
Bradley A Lloyd, Clinton K Murray, Faraz Shaikh, M Leigh Carson, Dana M Blyth, Elizabeth R Schnaubelt, Timothy J Whitman, David R Tribble
Introduction: All Department of Defense (DoD) guidance documents recommend cefazolin or clindamycin as post-trauma antibiotic prophylaxis for open soft-tissue injuries. Although not advocated, some patients with open soft-tissue injuries also received expanded Gram-negative coverage (EGN) prophylaxis based on the judgment of front-line trauma providers. During the study period, revised guidelines in 2011/2012 re-emphasized recommendations for using cefazolin or clindamycin, and stewardship efforts in the DoD trauma community aimed to reduce the practice of adding EGN to guideline-recommended antibiotic prophylaxis...
February 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29442252/survey-of-staphylococcus-aureus-in-a-general-pediatric-population-and-focus-on-isolates-with-three-clinically-relevant-toxin-encoding-genes
#8
Anne Filleron, Sarah Beauregard-Birba, Thibault Mura, Fabien Aujoulat, Anne Laure Michon, Michel Rodière, Tu Anh Tran, Eric Jeziorski, Hélène Marchandin
BACKGROUND: In children, surveys on Staphylococcus aureus have focused on specific infections, situations or strains but no study has so far given an overview on S. aureus isolation without any selection. Here, we describe the overall bacteriological and clinical characteristics of S. aureus isolation in children, with a special focus on isolates harbouring tst, sea, and/or luk-PV genes, respectively, encoding the three clinically relevant toxins: toxic shock syndrome toxin-1, enterotoxin A and Panton-Valentine leukocidin...
February 13, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29428033/definitive-wound-closure-techniques-in-fournier-s-gangrene
#9
Margaret Lauerman, Olga Kolesnik, Habeeba Park, Laura S Buchanan, William Chiu, Ronald B Tesoriero, Deborah Stein, Thomas Scalea, Sharon Henry
Necrotizing soft tissue infection of the perineum, or Fournier's gangrene (FG), is a morbid and mortal diagnosis. Despite the severity of FG, the optimal definitive wound closure strategy is unknown, as are long-term wound outcomes. A retrospective review was performed over a 3-year period at a single trauma center. Patients were managed according to our institutional approach focusing on primary wound closure and secondary intention healing in residual wounds. Overall 168 patients were included. Complete primary wound closure was accomplished in 39...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29426804/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biologic-therapies-an-infectious-diseases-perspective-cell-surface-receptors-and-associated-signaling-pathways
#10
REVIEW
J Aguilar-Company, M Fernández-Ruiz, R García-Campelo, A C Garrido-Castro, I Ruiz-Camps
BACKGROUND: The present review is part of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biologic therapies. AIMS: To review, from an infectious diseases perspective, the safety profile of therapies targeting cell surface receptors and associated signaling pathways among cancer patients and to suggest preventive recommendations...
February 6, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29424798/group-b-streptococcal-cellulitis-and-necrotizing-fasciitis-in-infants-a-systematic-review
#11
Monika Wojtera, Horace Cheng, Kyle Fiorini, Kevin Coughlin, Michelle Barton, Julie Strychowsky
BACKGROUND: There is no consensus regarding approaches to infantile group B streptococcal (GBS) head and neck cellulitis and necrotizing fasciitis. We present a case of GBS necrotizing cellulitis and summarizes the literature regarding the presentation and management of infantile head and neck GBS cellulitis and necrotizing fasciitis. METHODS: The literature was searched using PubMed, Web of Science, EMBASE, and Medline (inception to April 2017) by two independent review authors...
February 7, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29417764/prospective-evaluation-of-ceftriaxone-use-in-medical-and-emergency-wards-of-gondar-university-referral-hospital-ethiopia
#12
Asnakew Achaw Ayele, Begashaw Melaku Gebresillassie, Daniel Asfaw Erku, Eyob Alemayehu Gebreyohannes, Dessalegn Getnet Demssie, Amanual Getnet Mersha, Henok Getachew Tegegn
Ceftriaxone is among the most commonly utilized antibiotics owing to its high potency, wide spectrum of activity, and low risk of toxicity. It is used to treat different types of bacterial infections including pneumonia, bone infections, abdominal infections, Skin and soft tissue infections, urinary tract infections. However, evidence around the globe shows the misuse of Ceftriaxone. This study aimed at evaluating the appropriateness of ceftriaxone use in medical and emergency wards of Gondar university referral hospital (GURH), Northwest Ethiopia...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29417246/necrotizing-soft-tissue-infections-at-a-tertiary-referral-hospital-in-rwanda-epidemiology-and-risk-factors-for-mortality
#13
Christophe Mpirimbanyi, Jennifer Rickard, Charles Furaha, Faustin Ntirenganya
BACKGROUND: Necrotizing soft tissue infections (NSTI) are emergency surgical conditions with severe physiologic and metabolic derangement. These infections are associated with increased rates of mortality and morbidity worldwide, particularly in developing countries if not diagnosed and treated early. METHODS: This prospective, observational cohort study includes all patients aged 12 and above who presented at Department of Surgery, University Teaching Hospital of Kigali from April 2016 to January 2017 with NSTI...
February 7, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29409179/limb-salvage-for-malignant-bone-tumours-of-distal-tibia-with-dual-ipsilateral-vascularized-autogenous-fibular-graft-in-a-trapezoid-shaped-array-with-ankle-arthrodesis-and-preserving-subtalar-joint
#14
Chunlin Zhang, Bingfang Zeng, Kunpeng Zhu, Lei Zhang, Jianping Hu
BACKGROUND: The treatment of malignant tumours of the distal tibia is a challenging surgical problem due to the scarce soft tissue coverage and the instability of the ankle joint that often occurs after resection. However, there is no consensus on the ideal treatment for malignant tumours of the distal tibia. METHODS: We report a new reconstruction for five patients with high-grade osteosarcoma of distal tibia, using dual ipsilateral vascularized autogenous fibular graft in a trapezoid-shaped array and external fixator, with ankle arthrodesis and preserving subtalar joints...
December 20, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29402745/design-synthesis-and-antibacterial-evaluation-of-honokiol-derivatives
#15
Bo Wu, Su-Hong Fu, Huan Tang, Kai Chen, Qiang Zhang, Ai-Hua Peng, Hao-Yu Ye, Xing-Jun Cheng, Mao Lian, Zhen-Ling Wang, Li-Juan Chen
Staphylococcus aureus is a major and dangerous human pathogen that causes a range of clinical manifestations of varying severity, and is the most commonly isolated pathogen in the setting of skin and soft tissue infections, pneumonia, suppurative arthritis, endovascular infections, foreign-body associated infections, septicemia, osteomyelitis, and toxic shocksyndrome. Honokiol, a pharmacologically active natural compound derived from the bark of Magnolia officinalis, has antibacterial activity against Staphylococcus aureus which provides a great inspiration for the discovery of potential antibacterial agents...
June 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29402218/diabetes-and-the-occurrence-of-infection-in-primary-care-a-matched-cohort-study
#16
Waseem Abu-Ashour, Laurie K Twells, James E Valcour, John-Michael Gamble
BACKGROUND: People with diabetes may be at higher risk for acquiring infections through both glucose-dependent and biologic pathways independent of glycemic control. Our aim was to estimate the association between diabetes and infections occurring in primary care. METHODS: Using the Newfoundland and Labrador Sentinel of the Canadian Primary Care Sentinel Surveillance Network, patients with diabetes ≥18 years between 1 January 2008 and 31 March 2013 were included with at least 1-year of follow-up...
February 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29398609/the-use-of-seri%C3%A2-surgical-scaffolds-in-direct-to-implant-reconstruction-after-skin-sparing-mastectomy-a-retrospective-study-on-surgical-outcomes-and-a-systematic-review-of-current-literature
#17
Arjen A W M van Turnhout, Charlotte J J Franke, Eline J C Vriens-Nieuwenhuis, Wouter B van der Sluis
INTRODUCTION: Little is reported on surgical outcomes of SERI Surgical Scaffold, a bioresorbable silk-derived surgical scaffold, developed to provide soft-tissue support and repair, in implant/expander breast reconstruction. METHODS: A retrospective chart study was conducted of all patients who underwent direct-to-implant reconstruction with a SERI surgical scaffold after skin-sparing mastectomy, recording surgical characteristics, perioperative complications and reoperations...
February 1, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29380676/the-current-role-of-glycopeptides-in-the-treatment-of-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-not-neutropenic-adults-the-viewpoint-of-a-group-of-italian-experts
#18
Ercole Concia, Claudio Viscoli, Valerio Del Bono, Maddalena Giannella, Matteo Bassetti, Giuseppe Francesco De Rosa, Emanuele Durante Mangoni, Silvano Esposito, Massimo Giusti, Paolo Grossi, Francesco Menichetti, Federico Pea, Nicola Petrosillo, Mario Tumbarello, Stefania Stefani, Mario Venditti, Pierluigi Viale
Staphylococcus aureus is still an important problem in clinical and therapeutic area, worldwide. In Italy, in recent years, methicillin resistance remained stable, yet considerably high, the percentage of strains of MRSA being around 40%. It was deemed interesting and timely to carry out a consensus conference using the RAND/UCLA method to collect the opinion of a group of experts in infectious diseases on the role of glycopeptides in the management of MRSA infections within several clinical scenarios and namely in pneumonia, bacteremia and endocarditis, joint replacement infections, skin and soft tissue infections, diabetic foot, abdominal infections and central nervous system infections...
January 30, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29378565/comparison-of-the-efficacy-of-nafcillin-and-glycopeptides-as-definitive-therapy-for-patients-with-methicillin-susceptible-staphylococcus-aureus-bacteremia-a-retrospective-cohort-study
#19
Dong Hyun Oh, Jung Ju Kim, Jinnam Kim, Hye Seong, Se Ju Lee, Yong Chan Kim, Eun Jin Kim, In Young Jung, Woo Yong Jeong, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
BACKGROUND: Studies have shown that the prognosis of the treatment of methicillin-susceptible S. aureus (MSSA) with glycopeptides is inferior compared to treatment with β-lactam. However, there are only few studies comparing treatment with antistaphylococcal penicillin alone to glycopeptide treatment. The aim of this study was to compare the efficacy of nafcillin, an antistaphylococcal penicillin, with that of glycopeptides as a definitive therapy for MSSA bacteremia. METHODS: Patients with MSSA bacteremia recruited from a tertiary referral hospital were enrolled in this retrospective cohort study...
January 30, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29373845/daptomycin-treatment-in-vascular-graft-gram-positive-infections
#20
Francisco Arnaiz de Las Revillas, Marta Fernadez-Sampedro, Ana María Arnaiz-García, Manuel Gutierrez-Cuadra, Carlos Armiñanzas, Ivana Pulitani, Alejandro Ponton, Valentin Tascon, Ivan García, María Carmen Fariñas
BACKGROUND: Daptomycin is a bactericidal antibiotic approved for the treatment of skin and soft tissue infections and right-side endocarditis. However, there is a lack of published data outlining its usefulness in vascular graft infections (VGI). The aim of this study was to describe the clinical experience of the use of daptomycin in the treatment of VGI by Gram-positive bacteria. METHODS: This was a retrospective cohort study of patients diagnosed with VGI receiving daptomycin in a tertiary health care hospital from January 2010 to December 2012...
January 23, 2018: International Journal of Infectious Diseases: IJID
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