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https://www.readbyqxmd.com/read/27911319/autotaxin-is-related-to-metabolic-dysfunction-and-predicts-alzheimer-s-disease-outcomes
#1
Kelsey E McLimans, Auriel A Willette
BACKGROUND: Obesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease (AD). OBJECTIVE: Ecto-nucleotide pyrophosphatase/phosphodiesterase 2, also called autotaxin, is produced by beige adipose tissue, regulates metabolism, and is higher in AD prefrontal cortex (PFC). Autotaxin may be a novel biomarker of dysmetabolism and AD. METHODS: We studied Alzheimer's Disease Neuroimaging Initiative participants who were cognitively normal (CN; n = 86) or had mild cognitive impairment (MCI; n = 135) or AD (n = 66)...
December 1, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911289/the-brain-s-structural-connectome-mediates-the-relationship-between-regional-neuroimaging-biomarkers-in%C3%A2-alzheimer-s-disease
#2
Sneha Pandya, Amy Kuceyeski, Ashish Raj
Alzheimer's disease (AD), one of the most common causes of dementia in adults, is a progressive neurodegenerative disorder exhibiting well-defined neuropathological hallmarks. It is known that disease pathology involves misfolded amyloid-β (Aβ) and tau proteins, and exhibits a relatively stereotyped progression over decades. The relationship between AD neuropathological hallmarks (Aβ, hypometabolism, and tau proteins) and imaging biomarkers (MRI, AV-45/FDG-PET) is not fully understood. In addition, biomarker pathologies are oftentimes discordant, wherein it may show varying levels of abnormality across brain regions...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27909284/-organizing-pneumonia-with-high-radiotracer-concentration-on-fluorodeoxyglucose-positron-emission-tomography-mimicking-pleural-dissemination-of-lung-cancer-report-of-a-case
#3
Takahisa Matsuoka, Tetsu Yamada, Shinjiro Nagai, Katsunari Matsuoka, Mitsuhiro Ueda, Yoshihiro Miyamoto
A 68-year-old man was referred to our hospital because of an abnormal shadow in the chest roentgenogram. Chest computed tomography (CT) showed the nodule in the right upper lobe (S3), 17 mm in size. One month later, fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT scanning revealed positive reaction in the right upper lobe lesion and new lesion close to another lobe. In addition, interloblar small nodules were detected, 5 mm and 7 mm in size. A transbronchial brush cytology by bronchoscopy was performed, and the microscopic findings demonstrated the presence of atypical cells, suspected adenocarcinoma...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27908966/prudence-required-when-using-18f-fdg-pet-as-reference-standard-for-lymphoma-detection
#4
Hugo J A Adams, Thomas Christian Kwee
No abstract text is available yet for this article.
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27904873/evaluation-of-the-effect-of-tumor-position-on-standardized-uptake-value-using-time-of-flight-reconstruction-and-point-spread-function
#5
Yasuharu Wakabayashi, Kenichi Kashikura, Yasuyuki Takahashi, Hitoshi Yabe, Akihiro Ichikawa, Souichi Yamamoto, Ayumi Ishii, Kunio Doi
OBJECTIVES: The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). METHODS: A cylinder phantom with the sphere (30 mm diameter), located in the center was used in this study. Fluorine-18 fluorodeoxyglucose ((18)F-FDG) concentrations of 5...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904869/value-of-dedicated-head-and-neck-18-f-fdg-pet-ct-protocol-in-detecting-recurrent-and-metastatic-lesions-in-post-surgical-differentiated-thyroid-carcinoma-patients-with-high-serum-thyroglobulin-level-and-negative-131-i-whole-body-scan
#6
Mai Hong Son, Bui Quang Bieu, Le Ngoc Ha
OBJECTIVES: In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative (131)I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of (18)F-FDG PET/CT scan in DTC patients with high serum Tg level and negative (131)I WBS. METHODS: 69 post-surgical DTC patients with high serum Tg level and negative post ablation (131)I WBS were enrolled in this study...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904868/predictive-ability-of-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-pathological-complete-response-and-prognosis-after-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer-patients
#7
Sachiko Kiyoto, Yoshifumi Sugawara, Kohei Hosokawa, Rieko Nishimura, Natsumi Yamashita, Shozo Ohsumi, Teruhito Mochizuki
OBJECTIVES: The mortality of patients with locally advanced triple-negative breast cancer (TNBC) is high, and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is associated with improved prognosis. This retrospective study was designed and powered to investigate the ability of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) to predict pathological response to NAC and prognosis after NAC. METHODS: The data of 32 consecutive women with clinical stage II or III TNBC from January 2006 to December 2013 in our institution who underwent FDG-PET/CT at baseline and after NAC were retrospectively analyzed...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904837/positron-emission-tomography-computerized-tomography-for-tumor-response-assessment-a-review-of-clinical-practices-and-radiomics-studies
#8
Wei Lu, Wengen Chen
Even with recent advances in cancer diagnosis and therapy, treatment outcomes for many cancers remain dismal. Patients often show different response to the same therapy regimen, supporting the development of personalized medicine. 18F-FDG PET/CT has been used routinely in the assessment of tumor response, in prediction of outcomes, and in guiding personalized treatment. These assessments are mainly based on physician's subjective or semi-quantitative evaluation. Recent development in Radiomics provides a promising objective way for tumor response assessment, which uses computerized tools to extract a large number of image features that capture additional information not currently used in clinic that has prognostic value...
August 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/27904660/comparison-of-mri-ct-and-18f-fdg-pet-ct-in-the-diagnosis-of-local-and-metastatic-of-nasopharyngeal-carcinomas-an-updated-meta-analysis-of-clinical-studies
#9
Wang-Sheng Chen, Jian-Jun Li, Lan Hong, Zeng-Bao Xing, Fen Wang, Chang-Qing Li
BACKGROUND: A meta-analysis was conducted to evaluate the accuracy of MRI, CT and FDG PET/CT in TNM stage of nasopharyngeal carcinoma patients (NPC). METHODS: Through a search of studies from 1996 to April 2015, pooled estimated sensitivity, specificity, pooled diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curves and Q*-index were calculated. RESULTS: Totally 23 studies were included for analysis. In T stage, the pooled sensitivity, specificity, DOR and SROC of MRI were 0...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27904443/prognosis-estimation-under-the-light-of-metabolic-tumor-parameters-on-initial-fdg-pet-ct-in-patients-with-primary-extranodal-lymphoma
#10
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk, Nuri Arslan
BACKGROUND: Non-Hodgkin's lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27903746/intestinal-glycolysis-visualized-by-fdg-pet-ct-correlates-with-glucose-decrement-after-gastrectomy
#11
Cheol Ryong Ku, Narae Lee, Jae Won Hong, In Gyu Kwon, Woo Jin Hyung, Sung Hoon Noh, Eun Jig Lee, Mijin Yun, Arthur Cho
Gastrectomy method is known to influence glucose homeostasis. (18)F-fluorodeoxyglucose (FDG) PET/CT acquired after gastrectomy often reveals newly developed physiologic small bowel uptake. We correlated newly developed small bowel FDG uptake and glucose homeostasis in post-gastrectomy gastric cancer patients. We retrospectively analyzed 239 non-diabetic patients who underwent staging and follow-up FDG PET/CT before and after gastrectomy for gastric cancer. Post-operative small bowel glycolysis was quantified by recording intestinal total lesion glycolysis (TLG)...
November 30, 2016: Diabetes
https://www.readbyqxmd.com/read/27902603/purulent-lupus-panniculitis-unmasked-by-fdg-pet-ct-scan-a-case-report
#12
Kornelis S M van der Geest, Rada V Moerman, Klaas P Koopmans, Nicole D Holman, Wilbert M T Janssen
RATIONALE: Lupus panniculitis (LP) is a unique variant of cutaneous lupus erythematosus. Clinical manifestations are typically mild and include erythema, nodules, and small ulcers. In certain cases, diagnosing LP may be challenging. Skin overlying the typical subcutaneous inflammation may appear normal, and bacterial superinfections of the skin sometimes mask the underlying LP. It has been suggested that a computed tomography (CT) scan may help to identify obscure LP lesions. Here, we report a case of a 54-year-old woman with an unusually severe form of LP, in which the full disease extent was only revealed by a fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27901328/prognostic-value-of-interim-fdg-pet-ct-in-patients-older-than-60-years-with-diffuse-large-b-cell-lymphoma-treated-by-pmitcebo-plus-rituximab-comparison-between-deauville-5-point-scale-and-international-harmonization-project-criteria
#13
Naelle Lombion, Philippe Robin, Adrian Tempescul, Pierre Y LE Roux, Ulrike Schick, Gaëlle Guillerm, Jean C Ianotto, Christian Berthou, Pierre Y Salaün, Ronan Abgral
BACKGROUND: Advanced age is an independent poor prognostic factor of diffuse large B-cell lymphoma. PMitCEBO is an alternative to CHOP to decrease side effects in elderly patients. Many studies have shown prognostic value of an interim FDG PET-CT to predict survival. A recent consensus (ICML, Lugano 2013) has suggested using the 5-point scale Deauville criteria instead of those of the international harmonization project (IHP) to visually assess the response on interim PET. The objective of this study was to evaluate the prognostic value of an interim FDG PET-CT in patients older than 60 with treated DLBCL and to compare IHP and 5-PS Deauville visual interpretation to predict survival...
November 30, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27900869/-evaluation-of-five-years-of-treatment-of-erdheim-chester-disease-with-anakinra-case-report-and-overview-of-literature
#14
Zdeněk Adam, Hana Petrášová, Zdeněk Řehák, Renata Koukalová, Marta Krejčí, Luděk Pour, Eva Vetešníková, Aleš Čermák, Sabina Ševčíková, Petr Szturz, Zdeněk Král, Jiří Mayer
: Erdheim-Chester disease is a histiocytic neoplasm of diseases from the group of non-Langerhans-cell histiocytoses, formed by infiltrates of foamy histiocytes. These pathological histiocytes produce pro-inflammatory cytokines. Therefore Erdheim-Chester disease is called inflammatory histiocytary neoplasm. The disease is accompanied by clinical symptoms of systemic inflammatory response, i.e. B symptoms. Imaging examinations detect typical osteosclerotic changes affecting diaphyses and metaphyses of the lower long bones and fibrotic changes which affect the aorta wall and the vessels leading from it...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27900755/incidental-18f-fdg-pet-ct-bilateral-breast-uptake-due-to-carcinoma
#15
Domenico Albano, Mattia Bertoli, Maria Laura Morassi, Giovanni Bosio, Emanuela Orlando, Francesco Bertagna
We report a case of 71-year-old female patient, previously treated with chemotherapy and surgical resection of sigmoid tract of the large bowel for adenocarcinoma (pT3N1M0), who underwent a 18F-FDG PET/CT for a suspicious hepatic lesion detected at CT scan during follow-up. 18F-FDG PET/CT showed no abnormal uptake in the liver both at 60 minutes and 120 minutes after injection but revealed a pathological uptake in two breast nodules, (one localized in upper-internal-quadrant of the right breast and the other in the upper-external-quadrant of the left breast)...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27898648/18f-fdg-pet-ct-study-after-lung-biopsy-in-suspected-lung-cancer-patients-time-is-of-the-essence
#16
Chit Sum Jason Yeung, Besma Musaddaq, Sam Hare, Thomas Wagner
No abstract text is available yet for this article.
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27898647/diffusion-weighted-mri-and-18f-fdg-pet-ct-imaging-competition-or-synergy-as-diagnostic-methods-to-manage-sarcoma-of-the-uterus-a-systematic-review-of-the-literature
#17
Julien Dubreuil, Jeremie Tordo, Domenico Rubello, Francesco Giammarile, Andrea Skanjeti
AIM: To evaluate the diagnostic performance of fluorine-18-fluorodeoxyglucose PET/computed tomography (F-FDG-PET/CT) and MRI with diffusion-weighted images (DWI) in uterine sarcomas (US). PATIENTS AND METHODS: A systematic review was performed on Medline, ISI web of knowledge, and Scopus databases for studies reporting the diagnostic performance of F-FDG-PET/CT and DWI-MRI in US published up to 15 February 2016. Exclusion criteria were articles with fewer than five cases of US, without DWI-MRI, and previous series of patients from the same researcher team...
January 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27896807/fdg-pet-ct-imaging-of-therapeutic-response-in-granulomatous-lymphocytic-interstitial-lung-disease-glild-in-common-variable-immunodeficiency-cvid
#18
S Jolles, E Carne, M Brouns, T El-Shanawany, P Williams, C Marshall, P Fielding
Common variable immunodeficiency (CVID) is the most common severe adult primary immunodeficiency and is characterized by a failure to produce antibodies leading to recurrent predominantly sinopulmonary infections. Improvements in the prevention and treatment of infection with immunoglobulin replacement and antibiotics have resulted in malignancy, autoimmune, inflammatory and lymphoproliferative disorders emerging as major clinical challenges in the management of patients who have CVID. In a proportion of CVID patients, inflammation manifests as granulomas that frequently involve the lungs, lymph nodes, spleen and liver and may affect almost any organ...
November 28, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27895793/evaluation-of-recurrent-disease-in-the-re-staging-of-colorectal-cancer-by-18-f-fdg-pet-ct-use-of-cea-and-ca-19-9-in-patient-selection
#19
Agostino Chiaravalloti, Alessandro Fiorentini, Erika Palombo, Davide Rinino, Annamaria Lacanfora, Roberta Danieli, Carmen Di Russo, Daniele Di Biagio, Ettore Squillaci, Orazio Schillaci
The aim of the present retrospective study was to evaluate the sensitivity and specificity of fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing the recurrence of colorectal cancer (CRC) with regard to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). (18)F-FDG PET/CT was performed in 100 patients for the re-staging of CRC. Therapy was discontinued prior to the examination. The mean (± standard deviation) CEA value (measured ~30 days prior to PET/CT examination) was 23...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895731/advantages-and-disadvantages-of-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-carcinoma-of-unknown-primary
#20
Xiaozhou Yu, Xiaofeng Li, Xiuyu Song, Dong Dai, Lei Zhu, Yanjia Zhu, Jian Wang, Huiqin Zhao, Wengui Xu
Carcinoma of unknown primary is a type of malignant disease where the primary carcinoma cannot be identified by conventional examination, which presents challenges in diagnosis and therapy. This study aims to evaluate the detailed clinical value and indications of using fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-18 FDG PET/CT) in a large sample. A total of 449 patients who were selected under strict standards were retrospectively included in this study. F-18 FDG PET/CT accurately detected the primary carcinoma in 115 of 449 patients whose primaries could not be detected by conventional examination (25...
November 2016: Oncology Letters
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