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Maiko Shibasaki, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Makoto Hirota, Kenji Mitsudo, Yukihiko Ozawa, Iwai Tohnai
Introduction: Although chemoradiotherapy (CRT) for oral squamous cell carcinoma (SCC) has been shown to preserve organ function and improve cosmetic results, site-specific data, especially mandible, are limited. The aim of this study was to evaluate the predictability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on response to super-selective intra-arterial CRT for advanced SCC of the mandible. Methods: Fifteen patients with advanced SCC of the mandible underwent super-selective intra-arterial CRT followed by radical resection...
June 2018: Journal of Bone Oncology
Minhee Park, Ho Kyoung Hwang, Mijin Yun, Woo Jung Lee, Hoguen Kim, Chang Moo Kang
Objective: We aimed to investigate the metabolic characteristics of Solid pseudopapillary neoplasms (SPNs) in relation signal intensities on18 F-FDG PET scans. Summary Background Data: SPNs of the pancreas commonly show high uptake of 18F-FDG. However, the metabolic characteristics underlying the high18 F-FDG uptake in SPNs are not well characterized. Materials and Methods: mRNA expressions for glucose metabolism were analyzed in five SPNs, five pancreatic ductal adenocarcinomas (PCAs), and paired normal pancreatic tissues...
February 23, 2018: Oncotarget
Yiqiu Zhang, Beilei Li, Haojun Yu, Jun Hou, Hongcheng Shi
Ankylosing spondylitis (AS) is a form of arthritis that affects the spine, the sacroiliac joints, and sometimes the hips and shoulders. Andersson lesion (AL), was first described by Andersson in 1937 as a destructive vertebral body and discovertebral portion of the spine in AS. In this case, we report a 50 years old man with medical history of AS diagnosed AL by fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT).
March 20, 2018: Hellenic Journal of Nuclear Medicine
Chao Ma, Jing Lu, Guoqiang Chen, Weixing Wang, Fu Su, Xinhui Su
Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm that has been described in various locations throughout the body, but is rarely observed in systemic lymph nodes. We present a case of a 63 years old woman with left inguinal lymphadenopathy accompanied by low-grade fever. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) revealed abnormal higher18 F-FDG uptake on the neck, axillar, pulmonary hilar, mediastinal, mesenteric, retroperitoneal, pelvic and inguinal lymph nodes...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Chunmeng Chen, Chong Jiang, Lin Li
Retroperitoneal pleomorphic liposarcoma (RPLS) is the least common but the most aggressive subtype of liposarcoma. We herein report a case of tumor embolism (TE) to the inferior vena cava (IVC) and pulmonary arteries in a 54 years old woman with RPLS. The case suggests that fusion fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) can accurately detect occult TE. It also illustrates the usefulness of computed tomography (CT) and high18 F-FDG uptake by PET/CT imaging for diagnosing such findings as filling defect in the veins and beaded pulmonary arteries as TE...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Feifei Zhang, Wei Yang, Yuetao Wang, Haipeng Tang, Jianfeng Wang, Xiaoliang Shao, Ziyi Wang, Xiaoying Zhang, Ling Yang, Xiaosong Wang, Weihua Zhou
OBJECTIVE: Left ventricular mechanical dyssynchrony (LVMD) is an important factor in the prognosis of patients with myocardial infarction (MI). The aim of this study is to identify the influencing factors of LVMD in MI patients by radionuclide myocardial imaging. SUBJECTS AND METHODS: This study consisted of 91 patients who had a history of definite prior MI and underwent both technetium-99m methoxyisobutylisonitrile (99m Tc-MIBI) gated single photon emission tomography (SPET) myocardial perfusion imaging (MPI) and18 F-FDG positron emission tomography (PET) myocardial metabolic imaging...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Jiao Liu, Baoping Liu, Yanxia Yu, Fangfang Chao, Yan Liu, Xingmin Han
OBJECTIVE: In the follow-up of patients with differentiated thyroid cancer (DTC), several patients had elevated serum levels of antithyroglobulin antibody (TgAb), undetectable serum thyroglobulin (Tg), and negative radioiodine whole body scan (131 I-WBS). We describe the use of neck ultrasonography (US) and fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) imaging in these patients to investigate this clinically challenging problem and propose treating...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Galal Alobthani, Victor Romanov, Kayako Isohashi, Keiko Matsunaga, Tadashi Watabe, Hiroki Kato, Mitsuaki Tatsumi, Eku Shimosegawa, Jun Hatazawa
OBJECTIVE: Non-Hodgkin's lymphoma (NHL) cases with inconclusive biopsy findings are not infrequently referred for fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT). We searched for maximum standardized uptake value (SUVmax) cut-off values that could discriminate between indolent and aggressive NHL in conventional non-time of flight (non-TOF)18 F-FDG PET/CT and TOF18 F-FDG PET/CT. SUBJECTS AND METHODS: Retrospectively, 328 patients were selected by the following inclusion criteria: biopsy-proven NHL with no more than one histopathological type; new cases with less than 90 days between obtaining biopsy and18 F-FDG PET/CT scanning; recurrent cases with time interval more than six months since the last therapy with no history of transformation; and blood glucose less than 150mg/dL...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Cyrus Ayubcha, Mahdi Zirakchian Zadeh, Chamith S Rajapakse, Jan Hartvigsen, Mette Jensen Stochkendahl, William Raynor, Oswaldo Acosta-Montenegro, Thomas Werner, Hongming Zhuang, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: This study aimed to explore the age and weight-related metabolic trends in the spines of healthy male subjects using fluorine-18 fluorodeoxyglucose positron emission tomography (18 F-FDG PET) imaging. SUBJECTS AND METHODS: Forty three healthy male subjects (age 23-75 years, weight 50-145kg) were selected from the CAMONA study. A global assessment methodology was applied to the subjects'18 F-FDG 180 minute scans, where each region of the spine (cervical, thoracic and lumbar) was individually encapsulated in a single region of interest, and standardized uptake value (SUVmean) was calculated per respective region...
March 20, 2018: Hellenic Journal of Nuclear Medicine
Jongho Kim, Erika D Feller, Wengen Chen, Yuanyuan Liang, Vasken Dilsizian
OBJECTIVES: The feasibility of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for the diagnosis of left ventricular assist device (LVAD) infection has been demonstrated. Beyond the diagnoses of LVAD infection, the authors hypothesized that the pattern and site of the infection along its various components may significantly impact clinical management and patient outcome. BACKGROUND: In patients with end-stage heart failure, the clinical use of LVAD for destination therapy is on the rise, accompanied by a higher prevalence of infections and serious complications...
March 9, 2018: JACC. Cardiovascular Imaging
Karla Arévalo Ruales, Rosa Negueroles Albuixech, José Loaiza Gongora, Elena Grau García, José Ivorra Cortés, José A Román Ivorra
OBJECTIVE: Polymyalgia rheumatica (PR) can be associated with large vessel vasculitis (LVV). We evaluate the diagnostic role of18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and its impact on the treatment of LVV associated with PR. MATERIALS AND METHODS: Retrospective study of patients diagnosed with PR. Data was collected from health records. Blood analysis included acute-phase reactants (APR), C-reactive protein (CRP) and erythrocyte sedimentation rate...
March 14, 2018: Reumatología Clinica
Sonia L Betancourt Cuellar, Diana Palacio, Marcelo F Benveniste, Brett W Carter, Gregory Gladish
Positron emission tomography (PET) computed tomography (CT) with 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG) has been established as an effective modality for evaluation of cancer. Interpretations of patterns of physiologic18 F-FDG uptake by the heart is particularly difficult given the wide normal variations of18 F-FDG metabolic activity observed. Atypical patterns of focal or diffuse physiologic cardiac18 F-FDG uptake and post-therapeutic effects after radiation therapy, systemic diseases, or cardiomyopathy may also be confused with malignant disease on18 F-FDG PET/CT...
February 6, 2018: Current Problems in Diagnostic Radiology
Jinbo Yue, Qiuling Shi, Ting Xu, Melenda Jeter, Ting-Yu Chen, Ritsuko Komaki, Daniel R Gomez, Tinsu Pan, Charles S Cleeland, Zhongxing Liao, Xin Shelley Wang
PURPOSE: Clinician ratings of concurrent chemoradiation (CRT)-induced radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) are based on both imaging and patient-reported lung symptoms. We compared the value of patient-reported outcomes versus normal-lung uptake of18 F-fluoro-2-deoxyglucose in positron emission computed tomography (FDG PET/CT) during the last week of treatment, for indicating the development of grade ≥ 2 RP within 4 months of CRT completion...
March 16, 2018: Quality of Life Research
Rubens Gisbert Cury, Margarete de Jesus Carvalho, Fernando Jeyson Lopez Lasteros, Alice Estevo Dias, Maria Gabriela Dos Santos Ghilardi, Anderson Rodrigues Brandão Paiva, Artur Martins Coutinho, Carlos Alberto Buchpiguel, Manoel J Teixeira, Egberto Reis Barbosa, Erich Talamoni Fonoff
BACKGROUND: Olfactory dysfunction is a non-motor symptom of Parkinson's disease (PD) associated with reduction in quality of life. There is no evidence on whether improvements in olfaction after subthalamic deep brain stimulation (STN-DBS) may be directly attributable to motor improvement or whether this reflect a direct effect of DBS on olfactory brain areas. The aim of this study was to evaluate the effect of DBS on olfactory function (OF) in PD as well as to explore the correlation between these changes and changes in motor symptoms and brain metabolism...
March 13, 2018: World Neurosurgery
Joanna Gariani, Olwen Westerland, Sarah Natas, Hema Verma, Gary Cook, Vicky Goh
OBJECTIVES: To undertake a systematic review to determine the diagnostic performance of whole body MRI (WBMRI) including diffusion weighted sequences (DWI) compared to whole body computed tomography (WBCT) or18 F-fluorodeoxyglucose positron emission tomography/CT (18 F-FDG PET/CT) in patients with myeloma. METHODS: Two researchers searched the primary literature independently for WBMRI studies of myeloma. Data were extracted focusing on the diagnostic ability of WBMRI versus WBCT and18 F-FDG PET/CT...
April 2018: Critical Reviews in Oncology/hematology
Yong-Il Kim, Jin Chul Paeng, Young Sik Park, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
OBJECTIVE: The purposes of this study were to assess the relation between epidermal growth factor receptor (EGFR) mutation status and FDG PET/CT findings and to evaluate the influence of this relation on the use of FDG PET/CT parameters to establish a prognosis in cases of localized lung adenocarcinoma. MATERIALS AND METHODS: Patients with stage I and II lung adenocarcinomas were retrospectively enrolled. At the initial FDG PET/CT examination, maximum and peak standardized uptake, tumor-to-background ratio, and volumetric parameters of metabolic tumor volume and total lesion glycolysis were measured...
March 16, 2018: AJR. American Journal of Roentgenology
Lars Frings, Sabine Hellwig, Tobias Bormann, Timo S Spehl, Ralph Buchert, Philipp T Meyer
PURPOSE: The value of imaging regional glucose metabolism with [18 F]FDG PET for the prediction of progression from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) is controversial. The predictive value of imaging with [18 F]FDG PET was therefore tested and compared with that of imaging beta-amyloid load with [11 C]PIB PET in the same memory clinic population of MCI patients. METHODS: Thirty-nine patients with MCI who had undergone [18 F]FDG as well as [11 C]PIB PET were identified from a single-centre clinical registry...
March 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Feng Feng, Fulin Qiang, Aijun Shen, Donghui Shi, Aiyan Fu, Haiming Li, Mingzhu Zhang, Ganlin Xia, Peng Cao
Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with that of18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules (SPNs). Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs...
February 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Nosheen Fatima, Uz Zaman Maseeh
No abstract text is available yet for this article.
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Hugo Botha, William G Mantyh, Melissa E Murray, David S Knopman, Scott A Przybelski, Heather J Wiste, Jonathan Graff-Radford, Keith A Josephs, Christopher G Schwarz, Walter K Kremers, Bradley F Boeve, Ronald C Petersen, Mary M Machulda, Joseph E Parisi, Dennis W Dickson, Val Lowe, Clifford R Jack, David T Jones
Predicting underlying pathology based on clinical presentation has historically proven difficult, especially in older cohorts. Age-related hippocampal sclerosis may account for a significant proportion of elderly participants with amnestic dementia. Advances in molecular neuroimaging have allowed for detailed biomarker-based phenotyping, but in the absence of antemortem markers of hippocampal sclerosis, cases of mixed pathology remain problematic. We evaluated the utility of 18F-FDG-PET to differentiate flortaucipir tau PET negative from flortaucipir positive amnestic mild cognitive impairment and dementia and used an autopsy confirmed cohort to test the hypothesis that hippocampal sclerosis might account for the observed pattern...
March 12, 2018: Brain: a Journal of Neurology
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