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https://www.readbyqxmd.com/read/28215890/effect-of-oral-calcium-administration-on-the-cure-and-reproductive-performance-of-holstein-cows-diagnosed-with-puerperal-metritis
#1
Pablo Pinedo, Juan Velez, Gilberto Solano, Nelson Rodriguez, Julianne Naves, Gustavo M Schuenemann, Carlos Risco
Our objective was to evaluate the effect of oral calcium administration on clinical cure, survival, subsequent presentation of peripartal health disorders, and reproductive performance of Holstein cows diagnosed with puerperal metritis (PM) under certified organic management. A second objective was to evaluate the metabolic status at calving and at the time of PM diagnosis (d 0) in affected and matched healthy cows. Cows diagnosed with PM (n = 200) were assigned randomly to receive 1 of 2 treatments: (1) control received 3...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28209722/long-term-outcome-of-hematopoietic-stem-cell-transplantation-for-il2rg-jak3-scid-a-cohort-report
#2
Intan Juliana Abd Hamid, Mary A Slatter, Fiona McKendrick, Mark S Pearce, Andrew R Gennery
Hematopoietic stem cell transplantation (HSCT) cures the T-lymphocyte, B-lymphocyte and Natural Killer (NK) cell differentiation defect in IL2RG/JAK3 SCID. We evaluated long-term clinical features, longitudinal immunoreconstitution, donor chimerism and quality of life (QoL) of IL2RG/JAK3 SCID patients >2 years post-HSCT at our center. Clinical data were collated and patients/families answered PedsQL Generic Core Scale v4.0 questionnaires. We performed longitudinal analyses of CD3+, CD4+ naïve T-lymphocyte, CD19+ and NK cell numbers from pre-transplant until 15 years post-transplant...
February 16, 2017: Blood
https://www.readbyqxmd.com/read/28209496/uterine-leiomyosarcoma-epidemiology-contemporary-treatment-strategies-and-the-impact-of-uterine-morcellation
#3
Stephanie Ricci, Rebecca L Stone, Amanda N Fader
Leiomyosarcoma, a rare tumor subtype, accounts for 1% of all uterine malignancies, but contributes to a significant proportion of uterine cancer deaths. Surgery is considered the mainstay of treatment for all soft tissue sarcomas, including uterine variants. However, uterine leiomyosarcoma is challenging to diagnose preoperatively and can mimic the appearance of benign uterine leiomyomas. Recently, concerns have grown in this regard, as surgeons have utilized uterine morcellation and myomectomy procedures unknowingly in the setting of occult uterine sarcoma...
February 13, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28203249/autism-spectrum-disorder-detection-from-semi-structured-and-unstructured-medical-data
#4
Jianbo Yuan, Chester Holtz, Tristram Smith, Jiebo Luo
Autism spectrum disorder (ASD) is a developmental disorder that significantly impairs patients' ability to perform normal social interaction and communication. Moreover, the diagnosis procedure of ASD is highly time-consuming, labor-intensive, and requires extensive expertise. Although there exists no known cure for ASD, there is consensus among clinicians regarding the importance of early intervention for the recovery of ASD patients. Therefore, to benefit autism patients by enhancing their access to treatments such as early intervention, we aim to develop a robust machine learning-based system for autism detection by using Natural Language Processing techniques based on information extracted from medical forms of potential ASD patients...
December 2017: EURASIP Journal on Bioinformatics & Systems Biology
https://www.readbyqxmd.com/read/28195832/four-dimensional-printing-hierarchy-scaffolds-with-highly-biocompatible-smart-polymers-for-tissue-engineering-applications
#5
Shida Miao, Wei Zhu, Nathan J Castro, Jinsong Leng, Lijie Grace Zhang
The objective of this study was to four-dimensional (4D) print novel biomimetic gradient tissue scaffolds with highly biocompatible naturally derived smart polymers. The term "4D printing" refers to the inherent smart shape transformation of fabricated constructs when implanted minimally invasively for seamless and dynamic integration. For this purpose, a series of novel shape memory polymers with excellent biocompatibility and tunable shape changing effects were synthesized and cured in the presence of three-dimensional printed sacrificial molds, which were subsequently dissolved to create controllable and graded porosity within the scaffold...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28187778/whole-body-mri-in-pediatric-patients-with-cancer
#6
REVIEW
Marcos Duarte Guimarães, Julia Noschang, Sara Reis Teixeira, Marcel Koenigkam Santos, Henrique Manoel Lederman, Vivian Tostes, Vikas Kundra, Alex Dias Oliveira, Bruno Hochhegger, Edson Marchiori
Cancer is the leading cause of natural death in the pediatric populations of developed countries, yet cure rates are greater than 70% when a cancer is diagnosed in its early stages. Recent advances in magnetic resonance imaging methods have markedly improved diagnostic and therapeutic approaches, while avoiding the risks of ionizing radiation that are associated with most conventional radiological methods, such as computed tomography and positron emission tomography/computed tomography. The advent of whole-body magnetic resonance imaging in association with the development of metabolic- and function-based techniques has led to the use of whole-body magnetic resonance imaging for the screening, diagnosis, staging, response assessment, and post-therapeutic follow-up of children with solid sporadic tumours or those with related genetic syndromes...
February 10, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28185853/sustainable-management-and-utilisation-of-concrete-slurry-waste-a-case-study-in-hong-kong
#7
Md Uzzal Hossain, Dongxing Xuan, Chi Sun Poon
With the promotion of environmental protection in the construction industry, the mission to achieve more sustainable use of resources during the production process of concrete is also becoming important. This study was conducted to assess the environmental sustainability of concrete slurry waste (CSW) management by life cycle assessment (LCA) techniques, with the aim of identifying a resource-efficient solution for utilisation of CSW in the production of partition wall blocks. CSW is the dewatered solid residues deposited in the sedimentation tank after washing out over-ordered/rejected fresh concrete and concrete trucks in concrete batching plants...
February 6, 2017: Waste Management
https://www.readbyqxmd.com/read/28185350/development-of-a-strategy-for-the-total-chemical-synthesis-of-an-allergenic-protein-the-peach-ltp-pru-p-3
#8
Sofie Buhler, Jaap H Akkerdaas, Thelma A Pertinhez, Ronald Van Ree, Arnaldo Dossena, Stefano Sforza, Tullia Tedeschi
The possibility to obtain allergenic proteins by means of total chemical synthesis would be a big step forward in the development of cures to food allergy and in the study of the mechanism of allergic reactions, because this would allow to achieve control at the molecular level over the structure of the product and to study its relationship with the allergenic activity in fine details. This is instead not possible by using allergens produced by extraction from natural sources or by recombinant DNA techniques...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28183265/some-important-dietary-polyphenolic-compounds-an-anti-inflammatory-and-immunoregulatory-perspective
#9
Mayank Kinger, Sushil Kumar, Vinod Kumar
Inflammation plays an important role in maintaining the body's homeostasis. It repairs the damaged tissues of the body resulting from injury or infection. In addition, a diverse array of diseases like hepatitis, arthritis and colitis has been reported and described to be associated with inflammatory processes. Some autoimmune diseases like inflammatory bowel disease (IBD) emerge by the influence of numerous genes in complex environmental situations belongs to inflammation. The currently available processes for curing inflammation and related disorders facilitate the use of non steroidal anti-inflammatory drugs (NSAIDs)...
February 8, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28179527/hiv-specific-granzyme-b-but-not-interferon-%C3%AE-secreting-t-cells-are-associated-with-reduced-viral-reservoirs-in-early-hiv-infection
#10
Feng Yun Yue, Jared C Cohen, Mu Ho, A K M Nur-Ur Rahman, Jun Liu, Shariq Mujib, Aamir Saiyed, Sabrina Hundal, Alexandra Khozin, Phil Bonner, Daheng Liu, Erika Benko, Colin Kovacs, Mario Ostrowski
A major barrier to an Human Immunodeficiency Virus Type 1 (HIV) infection cure is the establishment of a viral reservoir despite cART. It is unclear how HIV-specific CTLs influence the size of the reservoir in early HIV infection. 28 subjects with early HIV infection were recruited to receive cART and followed for 48 weeks. HIV reservoirs in peripheral CD4+ T cells measured by cell associated proviral DNA and viral outgrowth cultures were determined at baseline and 48 weeks of cART. At baseline, Granzyme B and IFN-γ ELISpot assays were performed with peptides spanning the HIV proteome...
February 8, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28176651/lung-cancer-stem-cells-an-epigenetic-perspective
#11
Samriddhi Shukla, Sajid Khan, Sonam Sinha, Syed Musthapa Meeran
Lung cancer remains the major cause of human mortality among all the cancer types despite the colossal amount of efforts to prevent the cancer onset and to provide the appropriate cure. Recent reports have identified that important contributors of lung cancer-related mortality are the drug resistance and aggressive tumor relapse, the characteristics contributed by the presence of lung cancer stem cells (CSCs). The identification of lung CSCs is inherently complex due to the quiescent nature of lung epithelium, which makes the distinction between the normal lung epithelium and lung CSCs difficult...
February 5, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28168619/pure-endoscopic-management-of-epileptogenic-hypothalamic-hamartomas
#12
S Chibbaro, H Cebula, J Scholly, J Todeschi, I Ollivier, A Timofeev, M Ganau, P Di Emidio, M P Valenti, A M Staack, T Bast, B J Steinhoff, E Hirsch, P Kehrli, F Proust
Hypothalamic hamartomas (HH) are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Their usual clinical presentation is characterized by gelastic/dacrystic seizures which often become pharmaco-resistant and progress to secondary focal/generalized intractable epilepsy causing mostly in children cognitive and behavioral problems (particularly in cases of progressive epileptic encephalopathy) and precocious puberty. Whereas gelastic seizures can be surgically controlled either by resection of the lesion or disconnection (tissue-destructive) procedures, aimed at functionally prevent the spreading of the epileptic burst; generalized seizures tend to respond better to HH excision rather than isolated neocortical resections, which generally fail to control them...
February 7, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28161562/hindrance-of-1-4-dioxane-biodegradation-in-microcosms-biostimulated-with-inducing-or-non-inducing-auxiliary-substrates
#13
Mengyan Li, Yuanyuan Liu, Ya He, Jacques Mathieu, James Hatton, William DiGuiseppi, Pedro J J Alvarez
A microcosm study was conducted to assess two biostimulation strategies (relative to natural attenuation) to bioremediate 1,4-dioxane contamination at a site in west Texas. Dioxane concentrations were relatively low (<300 μg/L), which represents a potential challenge to sustain and induce specific degraders. Thus, biostimulation was attempted with an auxiliary substrate known to induce dioxane-degrading monooxygenases (i.e., tetrahydrohyran [THF]) or with a non-inducing growth substrate (1-butanol [1-BuOH])...
January 26, 2017: Water Research
https://www.readbyqxmd.com/read/28161157/effect-of-scoparia-dulcis-on-noise-stress-induced-adaptive-immunity-and-cytokine-response-in-immunized-wistar-rats
#14
Loganathan Sundareswaran, Sakthivel Srinivasan, Wankupar Wankhar, Rathinasamy Sheeladevi
BACKGROUND: Noise acts as a stressor and is reported to have impact on individual health depending on nature, type, intensity and perception. Modern medicine has no effective drugs or cure to prevent its consequences. Being an environmental stressor noise cannot be avoided; instead minimizing its exposure or consuming anti-stressor and adaptogens from plants can be considered. OBJECTIVES: The present study was carried out to evaluate the anti-stressor, adaptogen and immunostimulatory activity of Scoparia dulcis against noise-induced stress in Wistar rat models...
February 1, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28151933/specific-anti-glycan-antibodies-are-sustained-during-and-after-parasite-clearance-in-schistosoma-japonicum-infected-rhesus-macaques
#15
Y Y Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R Alan Wilson, Angela van Diepen, Cornelis H Hokke
BACKGROUND: Human immunity to Schistosoma infection requires many years of exposure, and multiple infections and treatments to develop. Unlike humans, rhesus macaques clear an established schistosome infection naturally at the same time acquiring immunity towards re-infection. In macaques, schistosome egg production decreases after 8 weeks post-infection and by week 22, physiological impairment of the worm caused by unclarified antibody-mediated processes is observed. Since strong antibody responses have been observed against schistosome glycan antigens in human and animal infections, we here investigate if anti-glycan antibodies are associated with immunity against schistosome infections in macaques...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28144573/glucosamine-and-chondroitin-for-the-treatment-of-osteoarthritis
#16
EDITORIAL
Haris S Vasiliadis, Konstantinos Tsikopoulos
The prevalence of primary or idiopathic osteoarthritis (OA) of knee and hip joints has substantially increased in general population during the last decades. Analgesics and non-steroidal anti-inflammatory drugs are currently extensively used as non-surgical treatment options. However, they act as symptomatic treatments, not offering a cure of OA and they are accused for an increased risk of adverse events. Glucosamine (GL) and chondroitin (CH) are nutritional supplements that have recently gained widespread use as treatment options for OA...
January 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28137265/targeting-acute-myeloid-leukemia-stem-cell-signaling-by-natural-products
#17
REVIEW
Kodappully Sivaraman Siveen, Shahab Uddin, Ramzi M Mohammad
Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15-20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of somatically acquired genetic changes, altering self-renewal, proliferation, and differentiation of hematopoietic progenitor cells, resulting in uncontrolled clonal proliferation of malignant progenitor myeloid cells in the bone marrow, peripheral blood, and occasionally in other body tissues. Treatment with modern chemotherapy regimen (cytarabine and daunorubicin) usually achieves high remission rates, still majority of patients are found to relapse, resulting in only 40-45% overall 5 year survival in young patients and less than 10% in the elderly AML patients...
January 30, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28131944/a-novel-injectable-tissue-adhesive-based-on-oxidized-dextran-and-chitosan
#18
Biji Balakrishnan, Dawlee Soman, Umashanker Payanam, Alexandre Laurent, Denis Labarre, Athipettah Jayakrishnan
: A surgical adhesive that can be used in different surgical situations with or without sutures is a surgeons' dream and yet none has been able to fulfill many such demanding requirements. It was therefore a major challenge to develop an adhesive biomaterial that stops bleeding and bond tissues well, which at the same time is non-toxic, biocompatible and yet biodegradable, economically viable and appealing to the surgeon in terms of the simplicity of application in complex surgical situations...
January 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28126183/-melanocytoma-and-meningeal-melanocytosis-similar-but-different-lesions
#19
Felipe Padilla-Vázquez, Víctor Hugo Escobar-de la Garma, Arturo Ayala-Arcipreste, Rafael Mendizábal-Guerra, Teresa Cuesta-Mejía
BACKGROUND: Meningeal melanomatosis is an extra-axial well-encapsulated malignant tumour with diffuse meningeal growth and dark coloration (due to high melanin contents), while meningeal melanocytoma is the focalized benign variant. Melanocytic lesions may be secondary to melanoma or be histologically benign, however, their diffuse nature makes them impossible to cure. Melanocytosis is a diffuse tumour that can form solitary extra-axial tumours, which invades the parenchyma and presents signs of malignancy with increased mitosis and Ki67, observed in 1 to 6% of immunopathological exams...
January 23, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28124639/new-routes-of-allergen-immunotherapy
#20
Mitat Aricigil, Nuray Bayar Muluk, Engin Umut Sakarya, Emine Güven Sakalar, Mehmet Senturk, William R Reisacher, Cemal Cingi
OBJECTIVES: Allergen immunotherapy is the only cure for immunoglobulin E mediated type I respiratory allergies. Subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) are the most common treatments. In this article, we reviewed new routes of allergen immunotherapy. METHODS: Data on alternative routes to allow intralymphatic immunotherapy (ILIT), epicutaneous immunotherapy (EPIT), local nasal immunotherapy (LNIT), oral immunotherapy (OIT), and oral mucosal immunotherapy (OMIT) were gathered from the literature and were discussed...
November 1, 2016: American Journal of Rhinology & Allergy
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