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https://www.readbyqxmd.com/read/29785433/the-immunomodulatory-activity-and-mechanism-of-docosahexenoic-acid-dha-on-immunosuppressive-mice-models
#1
Lirong Han, Huanna Lei, Ziwei Tian, Xu Wang, Dai Cheng, Chunling Wang
In this study, the immunomodulatory activity of docosahexaenoic acid (DHA) on the immunosuppressive BALB/c mice model and its molecular mechanism are elucidated. It was found that the weight indexes of the spleen and thymus were significantly increased by DHA (44.0 mg kg-1 and 88.0 mg kg-1) treatment in the prevention or cure groups. The result of macrophages showed that DHA (44.0 mg kg-1 and 88.0 mg kg-1) could promote the proliferation and phagocytosis activity of macrophages in the prevention or cure groups...
May 22, 2018: Food & Function
https://www.readbyqxmd.com/read/29778137/deciphering-natural-control-of-hiv-1-a-valuable-strategy-to-achieve-antiretroviral-therapy-termination
#2
REVIEW
Hamza Loucif, Steven Gouard, Xavier Dagenais-Lussier, Armstrong Murira, Simona Stäger, Cécile Tremblay, Julien Van Grevenynghe
Antiretroviral therapy (ART) has dramatically reduced HIV-1-associated morbidity and mortality, and has transformed HIV-1 infection into a manageable chronic condition by suppressing viral replication. However, despite recent patient care improvements, ART still fails to cure HIV-1 infection due to the inability to counteract immune defects and metabolic disturbances that are associated with residual inflammation alongside viral persistence. Life-long drug administration also results in multiple side-effects in patients including lipodystrophy and insulin resistance...
April 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29775725/anti-hepatitis-c-virus-activity-and-synergistic-effect-of-nymphaea-alba-extracts-and-bioactive-constituents-in-liver-infected-cells
#3
Sidra Rehman, Usman Ali Ashfaq, Bushra Ijaz, Sheikh Riazuddin
BACKGROUND: Without an effective vaccine, hepatitis C virus (HCV) remains a global threat, inflicting 170-300 million carriers worldwide at risk of cirrhosis and hepatocellular carcinoma (HCC). Though various direct acting antivirals have been redeemed the hepatitis C treatment, a few restraints persist including possible side effects, viral resistance emergence, excessive cost which restricts its availability to a common person. HYPOTHESIS: There is no preventive HCV vaccine available today so the discovery of potent antiviral natural flora and their bioactive constituents may help to develop preventive cures against HCV infection...
May 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29775637/modified-resin-infiltration-of-non-micro-and-cavitated-proximal-caries-lesions-in-vitro
#4
H Askar, F Schwendicke, J Lausch, H Meyer-Lueckel, S Paris
OBJECTIVE: Infiltrant resin (IR) is currently indicated for non-cavitated caries lesions. However, modifying the technique might expand its indication spectrum to micro-cavitated lesions. The present study aimed to evaluate the penetration/filling ability of a newly developed micro-filled infiltrant resin (MFIR) in non-, micro- and cavitated natural caries lesions. MATERIALS AND METHODS: Proximal lesions in 120 extracted human teeth with ICDAS-2 (n = 30), 3 (n = 45) and 5 (n = 45) lesions were etched with 15% hydrochloric acid gel for 2 min and allocated to one of the following treatments; IR: lesions (ICDAS-2, 3 and 5; each n = 15) were treated with commercial infiltrant resin for 3 min...
May 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29768230/screening-the-uv-blocking-and-antimicrobial-properties-of-herbal-nanoparticles-prepared-from-aloe-vera-leaves-for-textile-applications
#5
Karthik Subramani, Balu Kolathupalayam Shanmugam, Suriyaprabha Rangaraj, Manivasakan Palanisamy, Prabu Periasamy, Rajendran Venkatachalam
Nanomaterials play a vital role in textile industries due to their unique properties and applications. There is an increase in the use of nanoscale phyto products in textiles to control the bacterial infection in fabrics. Here, natural herbal nanoparticles of different sizes were prepared from shade-dried Aloe vera plant leaves using ball milling technique without any additives. The amorphous herbal A. vera nanoparticles possess an average particle size of 40 ± 2 nm and UV-absorption maximum at 269 nm...
June 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29765902/comparison-of-light-transmittance-in-dental-tissues-and-dental-composite-restorations-using-incremental-layering-build-up-with-varying-enamel-resin-layer-thickness
#6
Rodrigo Rocha Maia, Dayane Oliveira, Tracy D'Antonio, Fang Qian, Frederick Skiff
Objectives: To evaluate and compare light-transmittance in dental tissues and dental composite restorations using the incremental double-layer technique with varying layer thickness. Materials and Methods: B1-colored natural teeth slabs were compared to dental restoration build-ups with A2D and B1E-colored nanofilled, supra-nanofilled, microfilled, and microhybrid composites. The enamel layer varied from 0.3, 0.5, or 1.2 mm thick, and the dentin layer was varied to provide a standardized 3...
May 2018: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29764253/anti-inflammatory-local-effect-of-hydroxytyrosol-combined-with-pectin-alginate-and-olive-oil-on-trinitrobenzene-sulfonic-acid-induced-colitis-in-wistar-rats
#7
A Voltes, A Bermúdez, G Rodríguez-Gutiérrez, M L Reyes, C Olano, J Fernández-Bolaños, F de la Portilla
PURPOSE: Evaluate the efficacy of hydroxytyrosol in the local treatment of inflammatory colitis. Currently, the existing treatments for inflammatory bowel diseases does not cure the disease and it is associated with high rates of side effects and complications. Hydroxytyrosol is a phenyl-ethyl-alcohol derived from the hydrolysis of oleuropein and present in olive oil, previous studies have demonstrated the anti-inflammatory effect of dietary hydroxytyrosol supplement, with no toxicity...
May 15, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29764159/emerging-role-of-immunotherapy-for-childhood-cancers
#8
Rupert Handgretinger, Patrick Schlegel
Recent developments in cell and gene therapy have a great impact on the new therapeutic approaches in pediatric cancers. Monoclonal antibodies for neuroblastoma and bispecific antibodies for leukemia have induced significant clinical responses for otherwise chemorefractory patients. Moreover, cellular therapeutic approaches including chimeric antigen receptor (CAR) T-cells as well as natural killer (NK) cells have the potential to cure patients with so far incurable malignancies and are the basis for future new therapies for pediatric cancer...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29753132/prevention-of-eskape-pathogen-biofilm-formation-by-antimicrobial-peptides-wlbu2-and-ll37
#9
Qiao Lin, Berthony Deslouches, Ronald C Montelaro, Y Peter Di
OBJECTIVES: Bacterial biofilm-dependent infections (e.g., cystic fibrosis, surgical sites, and medical implants) are associated with enhanced drug-resistance and thus difficult to eradicate. The goal of this study was to systematically compare three distinct classes of antimicrobial peptides (AMPs) that include the clinically used antibiotic colistin, the natural AMP LL37, the engineered cationic-AMP WLBU2, and four commonly used antibiotics with different bactericidal mechanisms (tobramycin, ciprofloxacin, ceftazidime and vancomycin) for biofilm prevention properties...
May 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29751103/markerless-gene-knockout-and-integration-to-express-heterologous-biosynthetic-gene-clusters-in-pseudomonas-putida
#10
Kyeong Rok Choi, Jae Sung Cho, In Jin Cho, Dahyeon Park, Sang Yup Lee
Pseudomonas putida has gained much interest among metabolic engineers as a workhorse for producing valuable natural products. While a few gene knockout tools for P. putida have been reported, integration of heterologous genes into the chromosome of P. putida, an essential strategy to develop stable industrial strains producing heterologous bioproducts, requires development of a more efficient method. Current methods rely on time-consuming homologous recombination techniques and transposon-mediated random insertions...
May 8, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/29746687/medicine-without-cure-a-cluster-analysis-of-the-nature-of-medicine
#11
Thaddeus Metz
In his article "Prediction, Understanding, and Medicine," Alex Broadbent argues that the nature of medicine is determined by its competences, that is, which things it can do well. He argues that although medicine cannot cure well, it can do a good job of enabling people not only to understand states of the human organism and of what has caused them, but also to predict future states of it. From this, Broadbent concludes that medicine is (at least in part) essentially a practice of understanding and predicting, not curing...
May 9, 2018: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29745345/protective-effect-of-kaempferol-on-the-transgenic-drosophila-model-of-alzheimer-s-disease
#12
Yasir Hasan Siddique, Tanveer Beg, Smita Jyoti, Falaq Naz, X Rahul, Fahad Ali, Syed Kashif Ali, Ahmed Mohamed Reyad
BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation and deposition of β-amyloid peptides leading to a progressive neuronal damage and cell loss. Besides several hypotheses for explaining the neurodegenerative mechanisms, oxidative stress has been considered to be one of them. Till date, there is no cure for AD, but the pathogenesis of the disease could be delayed by the use of natural antioxidants. In this context, we decided to study the effect of kaempferol against the transgenic Drosophila expressing human Aβ-42...
May 8, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29743269/dictating-anisotropic-electric-conductivity-of-a-transparent-copper-nanowire-coating-by-the-surface-structure-of-wood
#13
Huizhang Guo, Martin Büchel, Xing Li, Aneliia Wäckerlin, Qing Chen, Ingo Burgert
In this article, a robust, air-stable, flexible and transparent copper (Cu) nanowire (NW) network coating on the surface of the wood is presented, based on a fusion welding of the Cu NWs by photonic curing. Thereby, an anisotropic conductivity can be achieved, which is originating from the structural organization of the wood body and its surface. Furthermore, the Cu NWs are protected from oxidation or wear by a commercially available paraffin wax-polyolefin, which also results in surface water repellency. The developed processing steps present a facile and flexible routine for applying Cu NW transparent conductors to abundant biomaterials and solve current manufacturing obstacles for corrosion-resistant circuits while keeping the natural appearance of the substrate...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29742858/long-term-outcome-of-a-fissurectomy-a-prospective-single-arm-study-of-50-operations-out-of-349-initial-patients
#14
Jean-David Zeitoun, Pierre Blanchard, Nadia Fathallah, Paul Benfredj, Nicolas Lemarchand, Vincent de Parades
PURPOSE: The surgical standard of care for patients with chronic anal fissure is still disputed. We aimed to assess the natural course of idiopathic anal fissure and the long-term outcome of a fissurectomy as a surgical treatment. METHODS: All consecutive patients referred to a single expert practitioner in a tertiary centre were primarily included. A fissurectomy was proposed in cases of refractory symptoms after 4 to 6 weeks of standard medical management. Only patients with idiopathic and noninfected anal fissures were included in this second subsample to undergo surgery...
April 2018: Annals of Coloproctology
https://www.readbyqxmd.com/read/29736264/clinical-management-of-friedreich-s-ataxia-a-report-of-two-cases
#15
Yannis Dionyssiotis, Athina Kapsokoulou, Anna Danopoulou, Maria Kokolaki, Athina Vadalouka
Introduction: Friedreich's ataxia (FDRA) is the most common autosomal recessive, early-onset ataxia. FDRA is a progressive neurodegenerative disease that mainly affects the posterior (dorsal) columns of the spinal cord resulting in sensory ataxia. It manifests in initial symptoms of poor coordination and gait disturbance. Case presentation: We present two cases, a brother (54 years old) and sister (56 years old), with FDRA that are chronically institutionalized for incomplete quadriplegia without spasticity...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29735957/macro-scale-strength-and-microstructure-of-zrw%C3%A2-o%C3%A2-cementitious-composites-with-tunable-low-thermal-expansion
#16
Jianshu Ouyang, Yangbo Li, Bo Chen, Dahai Huang
Concretes with engineered thermal expansion coefficients, capable of avoiding failure or irreversible destruction of structures or devices, are important for civil engineering applications, such as dams, bridges, and buildings. In natural materials, thermal expansion usually cannot be easily regulated and an extremely low thermal expansion coefficient (TEC) is still uncommon. Here we propose a novel cementitious composite, doped with ZrW₂O₈, showing a wide range of tunable thermal expansion coefficients, from 8...
May 7, 2018: Materials
https://www.readbyqxmd.com/read/29730298/exploring-the-biophysical-properties-of-phytosterols-in-the-plasma-membrane-for-novel-cancer-prevention-strategies
#17
REVIEW
Omar Fakih, Didem Sanver, David Kane, James L Thorne
Cancer is a global problem with no sign that incidences are reducing. The great costs associated with curing cancer, through developing novel treatments and applying patented therapies, is an increasing burden to developed and developing nations alike. These financial and societal problems will be alleviated by research efforts into prevention, or treatments that utilise off-patent or repurposed agents. Phytosterols are natural components of the diet found in an array of seeds, nuts and vegetables and have been added to several consumer food products for the management of cardio-vascular disease through their ability to lower LDL-cholesterol levels...
May 3, 2018: Biochimie
https://www.readbyqxmd.com/read/29727735/therapeutic-potential-of-wild-medicinal-plant-zizyphus-mauritiana-against-silica-induced-toxicity-in-wistar-albino-rats
#18
Rudra Prasad Dutta, M B Patil
ETHNOPHARMACOLOGICAL RELEVANCE: Zizyphus mauritiana (L.) of the family Rhamnaceae is a traditional herbal medicinal plant and commonly called as 'ber' (Indian jujube). It is traditionally used as food source and treats various diseases like malaria, asthma, pain killer, diarrhoea, typhoid, diabetes, and skin diseases, etc. AIM OF THE STUDY: This study aimed to evaluate the ability of extracts of barks of root and stem of Zizyphus mauritiana (ZM) to cure silica induced toxicity in Wistar albino rats...
May 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29725327/lymph-node-cellular-and-viral-dynamics-in-natural-hosts-and-impact-for-hiv-cure-strategies
#19
REVIEW
Nicolas Huot, Steven E Bosinger, Mirko Paiardini, R Keith Reeves, Michaela Müller-Trutwin
Combined antiretroviral therapies (cARTs) efficiently control HIV replication leading to undetectable viremia and drastic increases in lifespan of people living with HIV. However, cART does not cure HIV infection as virus persists in cellular and anatomical reservoirs, from which the virus generally rebounds soon after cART cessation. One major anatomical reservoir are lymph node (LN) follicles, where HIV persists through replication in follicular helper T cells and is also trapped by follicular dendritic cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29721498/aquaporins-as-targets-of-dietary-bioactive-phytocompounds
#20
REVIEW
Angela Tesse, Elena Grossini, Grazia Tamma, Catherine Brenner, Piero Portincasa, Raul A Marinelli, Giuseppe Calamita
Plant-derived bioactive compounds have protective role for plants but may also modulate several physiological processes of plant consumers. In the last years, a wide spectrum of phytochemicals have been found to be beneficial to health interacting with molecular signaling pathways underlying critical functions such as cell growth and differentiation, apoptosis, autophagy, inflammation, redox balance, cell volume regulation, metabolic homeostasis, and energy balance. Hence, a large number of biologically active phytocompounds of foods have been isolated, characterized, and eventually modified representing a natural source of novel molecules to prevent, delay or cure several human diseases...
2018: Frontiers in Molecular Biosciences
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