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https://www.readbyqxmd.com/read/28443893/trail-np-hybrids-for-cancer-therapy-a-review
#1
REVIEW
H Belkahla, G Herlem, F Picaud, T Gharbi, M Hémadi, S Ammar, O Micheau
Cancer is a worldwide health problem. It is now considered as a leading cause of morbidity and mortality in developed countries. In the last few decades, considerable progress has been made in anti-cancer therapies, allowing the cure of patients suffering from this disease, or at least helping to prolong their lives. Several cancers, such as those of the lung and pancreas, are still devastating in the absence of therapeutic options. In the early 90s, TRAIL (Tumor Necrosis Factor-related apoptosis-inducing ligand), a cytokine belonging to the TNF superfamily, attracted major interest in oncology owing to its selective anti-tumor properties...
April 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28441796/role-of-dietary-crocin-in-in-vivo-melanoma-tumor-remission
#2
Hamid A Bakshi, Faruck Lukmanul Hakkim, Smitha Sam, Farideh Javid
Background: Melanoma is a deadly form of malignancy. Early diagnosis might pave the way to cure but its aggressive nature leads to rapid dissemination and colonization of distant organs. Dietary herbs may play a significant role in prevention of cancer. In this study, we tested anti-tumor efficacy of the Crocus sativus derived active constituent crocin, well established to have anti-cancer properties in different cancer models by our group and other groups and other groups. Notably, crocin is reported to exert anti-proliferative effect on melanoma cells (B16F10) in vitro...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28433779/identification-of-new-anti-inflammatory-agents-based-on-nitrosporeusine-natural-products-of-marine-origin
#3
Satish Chandra Philkhana, Abhishek Kumar Verma, Gorakhnath R Jachak, Bibhabasu Hazra, Anirban Basu, D Srinivasa Reddy
Nitrosporeusines A and B are two recently isolated marine natural products with novel skeleton and exceptional biological profile. Interesting antiviral activity of nitrosporeusines and promising potential in curing various diseases, evident from positive data from various animal models, led us to investigate their anti-inflammatory potential. Accordingly, we planned and synthesized nitrosporeusines A and B in racemic as well as enantiopure forms. The natural product synthesis was followed by preparation of several analogues, and all the synthesized compounds were evaluated for in vitro and in vivo anti-inflammatory potential...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28433778/novel-lipid-mimetic-prodrugs-delivering-active-compounds-to-adipose-tissue
#4
Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
Obesity and associated pathologies are a dramatically growing problem. New therapies to prevent and/or cure them are strongly needed. Adipose tissue is a logical target for pharmacological intervention, since it is now recognized to exert an important endocrine function, secreting a variety of adipokines affecting, for example, adiposity and insulin resistance. This proof of principle work focuses on the development of novel lipid-mimetic prodrugs reaching fat deposits by the same lymphatic absorption route followed by dietary triglycerides...
April 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28432172/why-tuberculosis-control-programmes-fail-role-of-microlevel-and-macrolevel-factors-an-analysis-from-india
#5
Sudip Bhattacharya, Amarjeet Singh
India accounts for one-fourth of the global tuberculosis (TB) burden. The National TB Program was started in 1962. Over a period of time, some lacunae such as poor case detection rate and incomplete treatment were observed. Later, the government formulated the Revised National Tuberculosis Control Program (RNTCP), which achieved a case detection rate of 70% and a cure rate of 85%. Still, the problem of relapse and defaulter cases persists. In 2014, 6% defaulter cases were reported from India. RNTCP has also focused on microlevel aspects, that is, newer diagnostics such as GenXpert, line probe assay and medicines such as bedaquiline for drug-resistant TB...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28429679/mycobacterium-avium-complex-disease
#6
Charles L Daley
Despite the ubiqitous nature of Mycobacterium avium complex (MAC) organisms in the environment, relatively few of those who are infected develop disease. Thus, some degree of susceptibility due to either underlying lung disease or immunosuppression is required. The frequency of pulmonary MAC disease is increasing in many areas, and the exact reasons are unknown. Isolation of MAC from a respiratory specimen does not necessarily mean that treatment is required, as the decision to treatment requires the synthesis of clinical, radiographic, and microbiologic information as well as a weighing of the risks and benefits for the individual patient...
April 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28427974/factors-predicting-spontaneous-thrombosis-of-aggressive-cranial-dural-arteriovenous-fistulas
#7
Santhosh Kumar Kannath, Jayadevan Enakshy Rajan, Amirtendu Mukherjee, Sankara Sarma P
BACKGROUND: Dural arteriovenous fistula (DAVF) with cortical venous drainage (CVD) are known to be aggressive in clinical course and are usually managed promptly. Spontaneous resolution of DAVF is a rare phenomenon and usually occurs in benign type of fistulas. Spontaneous thrombosis of aggressive DAVF is an extremely rare occurrence. The present study aims to identify the incidence and factors determining spontaneous resolution of aggressive DAVF. METHODS: All the patients presenting to our institution with suspected DAVF during the study period (July 2013 - December 2015) were prospectively enrolled into a database...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28426681/preventing-treating-and-predicting-barbering-a-fundamental-role-for-biomarkers-of-oxidative-stress-in-a-mouse-model-of-trichotillomania
#8
Giovana de L T Vieira, Amy C Lossie, Donald C Lay, John S Radcliffe, Joseph P Garner
Barbering, where a "barber" mouse plucks hair from its cagemates or itself, is both a spontaneously occurring abnormal behavior in mice and a well validated model of Trichotillomania (TTM). N-Acetylcysteine, (NAC) a cysteine derived food additive, is remarkably effective in treating TTM patients, but its mechanism of action is unknown. Reactive Oxygen Species (ROS), also known as free radicals, form as a natural byproduct of the normal metabolism of oxygen. Under normal circumstances, cells are able to defend themselves against ROS damage with antioxidant pathways...
2017: PloS One
https://www.readbyqxmd.com/read/28423333/hunting-down-the-hiv-1-reservoir-a-starring-role-for-antibodies
#9
Hugo Mouquet
The persistence of viruses "hidden" in a reservoir of latently infected CD4(+) T cells under antiretroviral therapy is the major obstacle to an HIV-1 cure. Recently published in Nature, two seminal studies from Descours et al. (2017) and Nishimura et al. (2017) bring hope for tracking and possibly eradicating the HIV-1 reservoir.
April 18, 2017: Immunity
https://www.readbyqxmd.com/read/28422061/the-effect-of-particles-on-electrolytically-polymerized-thin-natural-mcf-rubber-for-soft-sensors-installed-in-artificial-skin
#10
Kunio Shimada, Osamu Mochizuki, Yoshihiro Kubota
The aim of this study is to investigate the effect of particles as filler in soft rubber sensors installed in artificial skin. We examine sensors made of natural rubber (NR-latex) that include magnetic particles of Ni and Fe₃O₄ using magnetic compound fluid (MCF). The 1-mm thickness of the electrolytically polymerized MCF rubber makes production of comparatively thin rubber sensors feasible. We first investigate the effect of magnetic particles Ni and Fe₃O₄ on the curing of MCF rubber. Next, in order to adjust the electric properties of the MCF rubber, we adopt Al₂O₃ dielectric particles...
April 19, 2017: Sensors
https://www.readbyqxmd.com/read/28421637/a-new-approach-to-models-of-the-4-5-dihydroxycyclopentenone-core-of-the-kodaistatins-a-d-elucidation-of-the-diol-configuration-in-kodaistatin-a
#11
Reinhard Brückner, David Peter
The kodaistatins are natural products from Aspergillus terreus. Being strongly anti-diabetic they hold some promise of a novel diabetes cure. However, considerations of that kind face two drawbacks. (1) The kodaistatins contain a heavily substituted pulvinone/cyclopentenone combination. (2) The kodaistatins are 1,2-diols, whose 3D structure have not been assigned yet. However, we can exclude two of the four possible stereostructures. We conclude that kodaistatin A is a trans-, not a cis-diol, from NMR comparisons with a pair of cis,trans-isomeric kodaistatin models, which we synthesized in 11 and 12 steps, respectively...
April 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28417082/improving-glucose-tolerance-by-muscle-damaging-exercise
#12
Chien-Te Ho, Machiko Otaka, Chia-Hua Kuo
Tissue damage is regarded as an unwanted medical condition to be avoided. However, introducing tolerable tissue damages has been used as a therapeutic intervention in traditional and complementary medicine to cure discomfort and illness. Eccentric exercise is known to cause significant necrosis and insulin resistance of skeletal muscle. The purpose of this study was to determine the magnitude of muscle damage and blood glucose responses during an oral glucose tolerance test (OGTT) after eccentric training in 21 young participants...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28404902/mechanism-of-modulation-through-pi3k-akt-pathway-about-nepeta-cataria-l-s-extract-in-non-small-cell-lung-cancer
#13
Jiaxin Fan, Yongrui Bao, Xiansheng Meng, Shuai Wang, Tianjiao Li, Xin Chang, Guanlin Yang, Tao Bo
Non-small cell lung cancer (NSCLC) is regarded as one of the major intractable diseases, which was cured mainly by chemotherapeutics in the clinical treatment at present. But it is still a vital mission for the current medical and researchers that hunting a natural medicine which have little side effects and high-efficiency against the NSCLC on account of the shortcomings on current drugs. Nepeta cataria L. plays an important role in anti-cancer treatment according to the reports which was recorded in the Chinese Pharmacopoeia of version 2015 and belongs to one of the Traditional Chinese medicine (TCM)...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402106/reply-to-comment-on-monitoring-network-and-interfacial-healing-processes-by-broadband-dielectric-spectroscopy-a-case-study-on-natural-rubber
#14
Marianella Hernandez, Antonio Mattia Grande, Sybrand van der Zwaag, Santiago J Garcia
Das et al. comment our publication on the use of broadband dielectric spectroscopy as a potential tool for monitoring healing processes in natural rubber. They argue that our interpretation of self-healing processes should be handled with care and that critical issues like rubber tackiness and sample fabrication for dielectric experiments were not properly addressed. We agree that tackiness in partially cured rubber does exist and that interpretation of dielectric experiments requires detailed insight into both the processes and the method, but we will try and re-argue below the correctness of our approach as reported in our publication...
April 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28401813/epistemological-challenges-in-contemporary-western-healthcare-systems-exemplified-by-people-s-widespread-use-of-complementary-and-alternative-medicine
#15
Anita Salamonsen, Rolf Ahlzén
Modern Western public healthcare systems offer predominantly publicly subsidized healthcare traditionally based on biomedicine as the most important basis to cure persons who suffer from disorders of somatic or psychiatric nature. To which extent this epistemological position is suitable for this purpose is under scientific debate and challenged by some people's personal understandings of health and illness, their individual illness experiences and their decision-making. Current studies show decreasing levels of patient trust in Western public healthcare and a widespread patient-initiated use of complementary and alternative medicine which is often linked to unmet patient-defined healthcare needs...
January 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28400005/toxoplasma-gondii-in-raw-and-dry-cured-ham-the-influence-of-the-curing-process
#16
Laura Herrero, María Jesús Gracia, Consuelo Pérez-Arquillué, Regina Lázaro, Antonio Herrera, Susana Bayarri
The aim of this work was to analyze Toxoplasma gondii in raw hams by mouse bioassay and to evaluate the effect of curing on the viability of the parasite to assess the risk of infection from eating dry-cured ham. After a serology study of 1200 pigs in Aragón (Spain), forty-one naturally infected pigs with different serological titers against T. gondii were selected. Two cured periods (9 and 12 months) were evaluated as well as the influence of the physicochemical composition of hams on T. gondii survival...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28395224/consumer-perception-of-dry-cured-sheep-meat-products-influence-of-process-parameters-under-different-evoked-contexts
#17
Juliana Cunha de Andrade, Elen Silveira Nalério, Citieli Giongo, Marcia Dutra de Barcellos, Gastón Ares, Rosires Deliza
The development of high-quality air-dried cured sheep meat products adapted to meet consumer demands represent an interesting option to add value to the meat of adult animals. The present study aimed to evaluate the influence of process parameters on consumer choice of two products from sheep meat under different evoked contexts, considering product concepts. A total of 375 Brazilian participants completed a choice-based conjoint task with three 2-level variables for each product: maturation time, smoking, and sodium reduction for dry-cured sheep ham, and natural antioxidant, smoking, and sodium reduction for sheep meat coppa...
April 5, 2017: Meat Science
https://www.readbyqxmd.com/read/28392952/clinical-implications-for-the-timely-diagnosis-of-mycobacterium-marinum-in-the-age-of-biologic-therapy-a-case-report-and-review-of-the-literature
#18
Chris J Lata, Kelle Edgar, Stephen Vaughan
Mycobacterium marinum infections typically present as cutaneous nodular lesions with a sporotrichoid lymphatic spread on extensor surfaces of extremities. The natural history of this infection can be altered if the host is immunosuppressed, leading to disseminated presentations. A detailed exposure history and high degree of suspicion for this indolent pathogen are often required for the correct diagnosis of this disease. We present a case of a 67-year-old male misdiagnosed with seronegative rheumatoid arthritis presenting with rheumatic nodules...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28389351/enhancing-colour-and-oxidative-stabilities-of-reduced-nitrites-turkey-meat-sausages-during-refrigerated-storage-using-fucoxanthin-purified-from-the-tunisian-seaweed-cystoseira-barbata
#19
Sabrine Sellimi, Ghada Ksouda, Abdelkarim Ben Slima, Rim Nasri, Marguerite Rinaudo, Moncef Nasri, Mohamed Hajji
The present study investigated the angiotensin-I converting enzyme (ACE) inhibitory activity and the antioxidant properties, in vitro and in cured meat sausages containing reduced levels of sodium nitrites, of fucoxanthin purified from the Tunisian brown seaweed Cystoseira barbata (CBFX). Results revealed that CBFX exhibited great scavenging activities against DPPH free radicals (EC50 = 136 μg/ml), peroxyl radicals in the linoleate-β-carotene system (EC50 = 43 μg/ml) and hydroxyl radicals generated by Fenton reaction (DNA nicking assay)...
April 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28386256/host-immune-responses-in-hiv-1-infection-the-emerging-pathogenic-role-of-siglecs-and-their-clinical-correlates
#20
REVIEW
Joanna Mikulak, Clara Di Vito, Elisa Zaghi, Domenico Mavilio
A better understanding of the mechanisms employed by HIV-1 to escape immune responses still represents one of the major tasks required for the development of novel therapeutic approaches targeting a disease still lacking a definitive cure. Host innate immune responses against HIV-1 are key in the early phases of the infection as they could prevent the development and the establishment of two hallmarks of the infection: chronic inflammation and viral reservoirs. Sialic acid-binding immunoglobulin-like lectins (Siglecs) belong to a family of transmembrane proteins able to dampen host immune responses and set appropriate immune activation thresholds upon ligation with their natural ligands, the sialylated carbohydrates...
2017: Frontiers in Immunology
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