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https://www.readbyqxmd.com/read/28230811/basigin-rs8259-polymorphism-confers-decreased-risk-of-chronic-heart-failure-in-a-chinese-population
#1
Mu-Peng Li, Xiao-Lei Hu, Yong-Long Yang, Yan-Jiao Zhang, Ji-Peng Zhou, Li-Ming Peng, Jie Tang, Xiao-Ping Chen
Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled...
February 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28223252/the-origin-and-evolution-of-basigin-bsg-gene-a-comparative-genomic-and-phylogenetic-analysis
#2
Xinyan Zhu, Shenglan Wang, Mingjie Shao, Jie Yan, Fei Liu
Basigin (BSG), also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147), plays various fundamental roles in the intercellular recognition involved in immunologic phenomena, differentiation, and development. In this study, we aimed to compare the similarities and differences of BSG among organisms and explore possible evolutionary relationships based on the comparison result. We used the extensive BLAST tool to search the metazoan genomes, N-glycosylation sites, the transmembrane region and other functional sites...
February 18, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28212934/effects-of-basil-seed-gum-cress-seed-gum-and-quince-seed-gum-on-the-physical-textural-and-rheological-properties-of-whipped-cream
#3
Reza Farahmandfar, Maryam Asnaashari, Mohammad Reza Salahi, Tandis Khosravi Rad
This study focuses on the physical, textural and rheological properties of low fat (LF) whipped cream with 30% fat content developed with Basil seed gum (BSG), Cress seed gum (CSG) and Quince seed gum (QSG) at the concentration of 0.1 and 0.3% (w/w) and comparison with high fat (HF) whipped cream sample (55%) as control. Flow curves were analyzed using Herschel bulkey and Carreau models through a fitting procedure. The rheological investigations confirmed that all samples were shear thinning fluid exhibiting a yield stress and thixotropy properties...
February 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28114689/endoscopy-in-patients-on-antiplatelet-or-anticoagulant-therapy-including-direct-oral-anticoagulants-british-society-of-gastroenterology-bsg-and-european-society-of-gastrointestinal-endoscopy-esge-guidelines
#4
Andrew M Veitch, Geoffroy Vanbiervliet, Anthony H Gershlick, Christian Boustiere, Trevor P Baglin, Lesley-Ann Smith, Franco Radaelli, Evelyn Knight, Ian M Gralnek, Cesare Hassan, Jean-Marc Dumonceau
No abstract text is available yet for this article.
April 2016: Endoscopy
https://www.readbyqxmd.com/read/28052119/pre-clinical-study-of-panobinostat-in-xenograft-and-genetically-engineered-murine-diffuse-intrinsic-pontine-glioma-models
#5
Tammy Hennika, Guo Hu, Nagore G Olaciregui, Kelly L Barton, Anahid Ehteda, Arjanna Chitranjan, Cecilia Chang, Andrew J Gifford, Maria Tsoli, David S Ziegler, Angel M Carcaboso, Oren J Becher
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG), or high-grade brainstem glioma (BSG), is one of the major causes of brain tumor-related deaths in children. Its prognosis has remained poor despite numerous efforts to improve survival. Panobinostat, a histone deacetylase inhibitor, is a targeted agent that has recently shown pre-clinical efficacy and entered a phase I clinical trial for the treatment of children with recurrent or progressive DIPG. METHODS: A collaborative pre-clinical study was conducted using both a genetic BSG mouse model driven by PDGF-B signaling, p53 loss, and ectopic H3...
2017: PloS One
https://www.readbyqxmd.com/read/28017969/ikzf1-expression-is-a-prognostic-marker-in-newly-diagnosed-standard-risk-multiple-myeloma-treated-with-lenalidomide-and-intensive-chemotherapy-a-study-of-the-german-myeloma-study-group-dsmm
#6
J Krönke, F Kuchenbauer, M Kull, V Teleanu, L Bullinger, D Bunjes, A Greiner, S Kolmus, S Köpff, M Schreder, L-O Mügge, C Straka, M Engelhardt, H Döhner, H Einsele, F Bassermann, R Bargou, S Knop, C Langer
Lenalidomide is an immunomodulatory compound with high clinical activity in multiple myeloma. Lenalidomide binding to the Cereblon (CRBN) E3 ubiquitin ligase results in targeted ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) leading to growth-inhibition of multiple myeloma cells. Recently, Basigin (BSG) was identified as another protein regulated by CRBN that is involved in the activity of lenalidomide. Here, we analyzed the prognostic value of IKZF1, IKZF3, CRBN and BSG mRNA expression levels in pretreatment plasma cells from sixty patients with newly diagnosed multiple myeloma uniformly treated with lenalidomide in combination with intensive chemotherapy within a clinical trial...
December 26, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27987886/fabrication-of-basil-seed-gum-nanoparticles-as-a-novel-oral-delivery-system-of-glutathione
#7
Sara Naji-Tabasi, Seyed Mohammad Ali Razavi, Hossein Mehditabar
Plant derived polymers like mucilage have evoked great attention in the field of functional food ingredient delivery. The objective of this study was to evaluate the potential of basil seed gum nanoparticles (BSG NPs) as an oral delivery system for glutathione (GSH). BSG NPs (1-0.25mgml(-1)) were fabricated by ion gelling technique and calcium was used as a cross-linking agent (0.7-0.3mgml(-1)). The results showed that BSG NPs (298-595nm) have spherical shape and the relative viscosity revealed that the possibility of agglomeration of BSG NPs is low...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27924368/a-quantitative-readability-analysis-of-patient-education-resources-from-gastroenterology-society-websites
#8
David R Hansberry, Sahil R Patel, Prateek Agarwal, Nitin Agarwal, Elizabeth S John, Ann M John, James C Reynolds
BACKGROUND AND AIMS: The lay public frequently access and rely on online information as a source of their medical knowledge. Many medical societies are unaware of national patient education material guidelines and subsequently fail to meet them. The goal of the present study was to evaluate the readability of patient education materials within the medical field of gastroenterology. METHODS: Two hundred fourteen articles pertaining to patient education materials were evaluated with ten well-established readability scales...
December 6, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27891213/uk-guidelines-for-the-management-of-soft-tissue-sarcomas
#9
REVIEW
Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan, Ian Judson
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the limitations of the data available. However, this makes it more important that STS are managed by teams, expert in such cases, to ensure consistent and optimal treatment, as well as recruitment to clinical trials, and the ongoing accumulation of further data and knowledge...
2016: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/27887813/migration-of-75-se-iv-in-crushed-beishan-granite-effects-of-the-iron-content
#10
Jiangang He, Bin Ma, Mingliang Kang, Chunli Wang, Zhe Nie, Chunli Liu
The diffusion of selenite (labeled with (75)Se) in compacted Beishan granite (BsG) was investigated using the in-diffusion capillary method at pH values from ∼2.0 to ∼11.0 under oxic and anoxic conditions. The results indicate that the apparent diffusion coefficient (Da) values of selenite in BsG always reached the minimum at approximately pH 5. Unexpectedly, the Da values under oxic conditions are nearly one order of magnitude lower than those under the anoxic conditions. Further characterization reveals the existence of redox-sensitive Fe(II)-containing components, which can be responsible for the great difference in Da values...
February 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27716564/efficient-conversion-of-pretreated-brewer-s-spent-grain-and-wheat-bran-by-submerged-cultivation-of-hericium-erinaceus
#11
Niklas Wolters, Christoph Schabronath, Gerhard Schembecker, Juliane Merz
Brewer's spent grain (BSG) and wheat bran (WB) are industrial byproducts that accumulate in millions of tons per year and are typically applied as animal feed. Since both byproducts show a great potential as substrates for fermentation, the approach developed in this study consists of utilizing these lignocellulosic byproducts for biomass production of the medicinal fungus Hericium erinaceus through submerged cultivation. To increase the biological efficiency of the bioconversion, acidic pretreatment was applied yielding a bioconversion of 38...
December 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27676629/identifying-multiple-potential-metabolic-cycles-in-time-series-from-biolog-experiments
#12
Mikhail Shubin, Katharina Schaufler, Karsten Tedin, Minna Vehkala, Jukka Corander
Biolog Phenotype Microarray (PM) is a technology allowing simultaneous screening of the metabolic behaviour of bacteria under a large number of different conditions. Bacteria may often undergo several cycles of metabolic activity during a Biolog experiment. We introduce a novel algorithm to identify these metabolic cycles in PM experimental data, thus increasing the potential of PM technology in microbiology. Our method is based on a statistical decomposition of the time-series measurements into a set of growth models...
2016: PloS One
https://www.readbyqxmd.com/read/27620465/the-influence-of-temperature-sucrose-and-lactose-on-dilute-solution-properties-of-basil-ocimumbasilicum-seed-gum
#13
Seyed Elias Mirabolhassani, Ali Rafe, Seyed M A Razavi
Hydrocolloid interactions with solvent/cosolutes play a vital role in the resolution of their functional properties. Basil seed gum (BSG) is a plant-derived hydrocolloid which has been found many applications in food formulations as stabilizer, emulsifier, thickener and gelling agents. Sucrose and lactose are the most effective sugars in textural and sensorial properties of bakery and dairy products which adding them to solutions containing hydrocolloids can be helpful to approach a proper formula. In this paper, the effect of temperature (25-65°C), sucrose (10, 20, 30 and 40%) and lactose (5, 10 and 15%) were investigated through some molecular parameters of BSG...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27610599/report-of-the-association-of-coloproctology-of-great-britain-and-ireland-british-society-of-gastroenterology-colorectal-polyp-working-group-the-development-of-a-complex-colorectal-polyp-minimum-dataset
#14
A Chattree, J A Barbour, S Thomas-Gibson, P Bhandari, B P Saunders, A M Veitch, J Anderson, B J Rembacken, M B Loughrey, R Pullan, W V Garrett, G Lewis, S Dolwani, M D Rutter
AIM: The management of large non-pedunculated colorectal polyps (LNPCPs) is complex, with widespread variation in management and outcome, even amongst experienced clinicians. Variations in the assessment and decision-making processes are likely to be a major factor in this variability. The creation of a standardized minimum dataset to aid decision-making may therefore result in improved clinical management. METHOD: An official working group of 13 multidisciplinary specialists was appointed by the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG) to develop a minimum dataset on LNPCPs...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27608558/silver-anniversary-for-bsg
#15
(no author information available yet)
No abstract text is available yet for this article.
September 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27593809/adult-brainstem-gliomas-retrospective-analysis-of-51-patients
#16
Goran Tasic, Nikola Repac, Igor Nikolic, Vojislav Bogosavljevic, Vul Scepanovic, Aleksandar Janicijevic, Aleksandra Eric-Nikolic, Lukas Rasulic
AIM: Brain stem gliomas constitute less than 2% of brain tumors in adults. Therapeutic options are limited and brainstem gliomas are associated with a high morbidity and mortality. MATERIAL AND METHODS: We reviewed the records of 51 patients with brainstem gliomas treated at the Institute of Neurosurgery, Clinical Center of Serbia in Belgrade between 1998 and 2012. We recorded demographic and clinical variables as well as radiological findings and survival. RESULTS: Of the 51 patients 62...
April 13, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27507023/establishment-and-application-of-an-analytical-in-house-database-ihdb-for-rapid-discrimination-of-bacillus-subtilis-group-bsg-using-whole-cell-maldi-tof-ms-technology
#17
Chien-Hsun Huang, Lina Huang, Mu-Tzu Chang, Kuo-Lung Chen
Members of the Bacillus subtilis group (BSG) possess industrial applicability; unfortunately, B. subtilis and its phylogenetically closest species are indistinguishable from one another using 16S rDNA sequencing, physiological and biochemical tests. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is a relatively novel technique for the fast and reliable identification of microorganisms. The aim of this study was to construct a unique analytical in-house database (IHDB) for BSG discrimination based on whole-cell protein fingerprinting using MALDI-TOF MS, as well as to discover biomarkers from the MS peaks to generate a classification model for further differentiation using the ClinProTools software...
August 6, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27503893/xkr8-phospholipid-scrambling-complex-in-apoptotic-phosphatidylserine-exposure
#18
Jun Suzuki, Eiichi Imanishi, Shigekazu Nagata
Xk-related protein (Xkr) 8, a protein carrying 10 transmembrane regions, is essential for scrambling phospholipids during apoptosis. Here, we found Xkr8 as a complex with basigin (BSG) or neuroplastin (NPTN), type I membrane proteins in the Ig superfamily. In BSG(-/-)NPTN(-/-) cells, Xkr8 localized intracellularly, and the apoptosis stimuli failed to expose phosphatidylserine, indicating that BSG and NPTN chaperone Xkr8 to the plasma membrane to execute its scrambling activity. Mutational analyses of BSG showed that the atypical glutamic acid in the transmembrane region is required for BSG's association with Xkr8...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27491307/application-of-active-edible-coatings-made-from-basil-seed-gum-and-thymol-for-quality-maintenance-of-shrimp-during-cold-storage
#19
Naimeh Khazaei, Mohsen Esmaiili, Zahra Emam-Djomeh
BACKGROUND: To improve the quality of Pacific white shrimp (Litopenaeus vannamei), active coating solutions were prepared by dissolving 10 g L(-1) of basil seed gum (BSG) and adding various levels of thymol (6, 8, and 10 % w/w based on gum weight) and glycerol (3.5 g L(-1) ) as plasticizer. The effects of coating solutions (CS1-4) on the quality changes of shrimps during refrigerated storage of 20 days were investigated. RESULTS: Total volatile basic nitrogen (TVB-N) value in shrimp coated with CS4 (containing 10%w/w thymol) was slightly higher than the upper threshold of 300 mg kg(-1) on the 18th day, while that of uncoated shrimp increased to or over the threshold value on the 7th day...
August 5, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27420938/snp-at-mir-483-5p-binding-site-in-the-3-untranslated-region-of-the-bsg-gene-is-associated-with-susceptibility-to-esophageal-cancer-in-a-chinese-population
#20
H Y Li, Y C Liu, Y H Bai, M Sun, L Wang, X B Zhang, B Cai
The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched controls using polymerase chain reaction restriction and direct sequencing. The functional variants resulting from the BSG rs11473 SNP were investigated using a luciferase activity assay and validated by immunoblotting...
June 20, 2016: Genetics and Molecular Research: GMR
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