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Adam Dangoor, Beatrice Seddon, Craig Gerrand, Robert Grimer, Jeremy Whelan, Ian Judson
Soft tissue sarcomas (STS) are rare tumours arising in mesenchymal tissues, and can occur almost anywhere in the body. Their rarity, and the heterogeneity of subtype and location means that developing evidence-based guidelines is complicated by the limitations of the data available. However, this makes it more important that STS are managed by teams, expert in such cases, to ensure consistent and optimal treatment, as well as recruitment to clinical trials, and the ongoing accumulation of further data and knowledge...
2016: Clinical Sarcoma Research
Jiangang He, Bin Ma, Mingliang Kang, Chunli Wang, Zhe Nie, Chunli Liu
The diffusion of selenite (labeled with (75)Se) in compacted Beishan granite (BsG) was investigated using the in-diffusion capillary method at pH values from ∼2.0 to ∼11.0 under oxic and anoxic conditions. The results indicate that the apparent diffusion coefficient (Da) values of selenite in BsG always reached the minimum at approximately pH 5. Unexpectedly, the Da values under oxic conditions are nearly one order of magnitude lower than those under the anoxic conditions. Further characterization reveals the existence of redox-sensitive Fe(II)-containing components, which can be responsible for the great difference in Da values...
November 9, 2016: Journal of Hazardous Materials
Niklas Wolters, Christoph Schabronath, Gerhard Schembecker, Juliane Merz
Brewer's spent grain (BSG) and wheat bran (WB) are industrial byproducts that accumulate in millions of tons per year and are typically applied as animal feed. Since both byproducts show a great potential as substrates for fermentation, the approach developed in this study consists of utilizing these lignocellulosic byproducts for biomass production of the medicinal fungus Hericium erinaceus through submerged cultivation. To increase the biological efficiency of the bioconversion, acidic pretreatment was applied yielding a bioconversion of 38...
October 1, 2016: Bioresource Technology
Mikhail Shubin, Katharina Schaufler, Karsten Tedin, Minna Vehkala, Jukka Corander
Biolog Phenotype Microarray (PM) is a technology allowing simultaneous screening of the metabolic behaviour of bacteria under a large number of different conditions. Bacteria may often undergo several cycles of metabolic activity during a Biolog experiment. We introduce a novel algorithm to identify these metabolic cycles in PM experimental data, thus increasing the potential of PM technology in microbiology. Our method is based on a statistical decomposition of the time-series measurements into a set of growth models...
2016: PloS One
Seyed Elias Mirabolhassani, Ali Rafe, Seyed M A Razavi
Hydrocolloid interactions with solvent/cosolutes play a vital role in the resolution of their functional properties. Basil seed gum (BSG) is a plant-derived hydrocolloid which has been found many applications in food formulations as stabilizer, emulsifier, thickener and gelling agents. Sucrose and lactose are the most effective sugars in textural and sensorial properties of bakery and dairy products which adding them to solutions containing hydrocolloids can be helpful to approach a proper formula. In this paper, the effect of temperature (25-65°C), sucrose (10, 20, 30 and 40%) and lactose (5, 10 and 15%) were investigated through some molecular parameters of BSG...
September 13, 2016: International Journal of Biological Macromolecules
Amit Chattree, Jamie A Barbour, Siwan Thomas-Gibson, Pradeep Bhandari, Brian P Saunders, Andrew M Veitch, John Anderson, Bjorn J Rembacken, Maurice B Loughrey, Rupert Pullan, William V Garrett, Gethin Lewis, Sunil Dolwani, Matthew D Rutter
AIM: The management of large non-pedunculated colorectal polyps (LNPCP) is complex, with widespread variation in management and outcome, even amongst experienced clinicians. Variation in the assessment and decision-making processes are likely to be a major factor in this variability. The creation of a standardised minimum dataset to aid decision making may therefore result in improved clinical management. METHOD: An official working group of thirteen multidisciplinary specialists was appointed by the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and the British Society of Gastroenterology (BSG) to develop a minimum dataset on LNPCP...
September 9, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
(no author information available yet)
No abstract text is available yet for this article.
September 9, 2016: British Dental Journal
Goran Tasic, Nikola Repac, Igor Nikolic, Vojislav Bogosavljevic, Vul Scepanovic, Aleksandar Janicijevic, Aleksandra Eric-Nikolic, Lukas Rasulic
AIM: Brain stem gliomas constitute less than 2% of brain tumors in adults. Therapeutic options are limited and brainstem gliomas are associated with a high morbidity and mortality. MATERIAL AND METHODS: We reviewed the records of 51 patients with brainstem gliomas treated at the Institute of Neurosurgery, Clinical Center of Serbia in Belgrade between 1998 and 2012. We recorded demographic and clinical variables as well as radiological findings and survival. RESULTS: Of the 51 patients 62...
April 13, 2016: Turkish Neurosurgery
Chien-Hsun Huang, Lina Huang, Mu-Tzu Chang, Kuo-Lung Chen
Members of the Bacillus subtilis group (BSG) possess industrial applicability; unfortunately, B. subtilis and its phylogenetically closest species are indistinguishable from one another using 16S rDNA sequencing, physiological and biochemical tests. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is a relatively novel technique for the fast and reliable identification of microorganisms. The aim of this study was to construct a unique analytical in-house database (IHDB) for BSG discrimination based on whole-cell protein fingerprinting using MALDI-TOF MS, as well as to discover biomarkers from the MS peaks to generate a classification model for further differentiation using the ClinProTools software...
August 6, 2016: Molecular and Cellular Probes
Jun Suzuki, Eiichi Imanishi, Shigekazu Nagata
Xk-related protein (Xkr) 8, a protein carrying 10 transmembrane regions, is essential for scrambling phospholipids during apoptosis. Here, we found Xkr8 as a complex with basigin (BSG) or neuroplastin (NPTN), type I membrane proteins in the Ig superfamily. In BSG(-/-)NPTN(-/-) cells, Xkr8 localized intracellularly, and the apoptosis stimuli failed to expose phosphatidylserine, indicating that BSG and NPTN chaperone Xkr8 to the plasma membrane to execute its scrambling activity. Mutational analyses of BSG showed that the atypical glutamic acid in the transmembrane region is required for BSG's association with Xkr8...
August 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
Naimeh Khazaei, Mohsen Esmaiili, Zahra Emam-Djomeh
BACKGROUND: To improve the quality of Pacific white shrimp (Litopenaeus vannamei), active coating solutions were prepared by dissolving 10 g L(-1) of basil seed gum (BSG) and adding various levels of thymol (6, 8, and 10 % w/w based on gum weight) and glycerol (3.5 g L(-1) ) as plasticizer. The effects of coating solutions (CS1-4) on the quality changes of shrimps during refrigerated storage of 20 days were investigated. RESULTS: Total volatile basic nitrogen (TVB-N) value in shrimp coated with CS4 (containing 10%w/w thymol) was slightly higher than the upper threshold of 300 mg kg(-1) on the 18th day, while that of uncoated shrimp increased to or over the threshold value on the 7th day...
August 5, 2016: Journal of the Science of Food and Agriculture
H Y Li, Y C Liu, Y H Bai, M Sun, L Wang, X B Zhang, B Cai
The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer patients and 636 cancer-free age- and gender-matched controls using polymerase chain reaction restriction and direct sequencing. The functional variants resulting from the BSG rs11473 SNP were investigated using a luciferase activity assay and validated by immunoblotting...
2016: Genetics and Molecular Research: GMR
Xingzhu Ju, Shanhui Liang, Jun Zhu, Guihao Ke, Hao Wen, Xiaohua Wu
Our preliminary study found that CD147 is related to radioresistance and maybe an adverse prognostic factor in cervical cancer. To date, the mechanisms underlying CD147-induced radioresistance in cervical cancer remain unclear. In the present study, we investigated the mechanisms by which CD147 affects radiosensitivity in cervical cancer both in vitro and in vivo. In this study, the clonogenic assay showed that radiosensitivity was significantly higher in the experimental group (the CD147-negative cell lines) than in the control group (the CD147-positive cell lines)...
2016: American Journal of Translational Research
Z Gokce-Samar, P A Beuriat, C Faure-Conter, C Carrie, S Chabaud, L Claude, F Di Rocco, C Mottolese, A Szathmari, C Chabert, D Frappaz
BACKGROUND: The median survival of patients with diffuse intrinsic pontine glioma (DIPG) remains less than 1 year. The BSG 98 pre-irradiation chemotherapy protocol showed a significant increase in overall survival. In contrast to current treatment strategies, patients did not have to undergo surgical stereotactic biopsy, which can sometimes lead to complications, to be included in this protocol. MATERIALS AND METHODS: We retrospectively reviewed all the cases of DIPG that were treated in our department from September 15, 2004 to September 15, 2014...
August 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Michele Michelin, José António Teixeira
Agricultural feedstocks (brewers' spent grain - BSG, corncob - CC, corn husk - CH, wheat straw - WS and Luffa sponge - LS) were pretreated by liquid hot water (LHW) in order to increase cellulose recovery and enzymatic saccharification. LHW-pretreatment resulted in hemicellulose solubilization, and solids enriched in cellulose. Chemical analysis showed different susceptibilities of the feedstocks to LHW-pretreatment and enzymatic hydrolysis. Pretreated feedstocks presented higher crystallinity (determined through X-ray diffraction) and thermal stability (determined through thermogravimetric analysis) than untreated feedstocks...
September 2016: Bioresource Technology
Joseph D Feuerstein, Natalia E Castillo, Mona Akbari, Edward Belkin, Jeffrey J Lewandowski, Christine M Hurley, Samuel Lloyd, Daniel A Leffler, Adam S Cheifetz
BACKGROUND: Barrett's esophagus (BE) is a condition that has a small but important risk of progressing to esophageal cancer. To date, no study has assessed the strength of evidence supporting the recommendations for BE. We sought to assess the overall quality of the recommendations and strength of the BE using the AGREE II instrument. METHODS: A PubMed search was performed to identify guidelines published pertaining to BE. Every guideline was reviewed using the AGREE II format to assess the methodological rigor and validity of the guideline...
October 2016: Digestive Diseases and Sciences
Ruth Eichner, Michael Heider, Vanesa Fernández-Sáiz, Frauke van Bebber, Anne-Kathrin Garz, Simone Lemeer, Martina Rudelius, Bianca-Sabrina Targosz, Laura Jacobs, Anna-Maria Knorn, Jolanta Slawska, Uwe Platzbecker, Ulrich Germing, Christian Langer, Stefan Knop, Herrmann Einsele, Christian Peschel, Christian Haass, Ulrich Keller, Bettina Schmid, Katharina S Götze, Bernhard Kuster, Florian Bassermann
Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN), a substrate receptor of the CRL4 ubiquitin ligase complex, is the primary target by which IMiDs mediate anticancer and teratogenic effects. Here we identify a ubiquitin-independent physiological chaperone-like function of CRBN that promotes maturation of the basigin (BSG; also known as CD147) and solute carrier family 16 member 1 (SLC16A1; also known as MCT1) proteins...
July 2016: Nature Medicine
S Burdo, A Giuliani, L Dalla Costa
OBJECTIVE: To identify the influence of the first implanted ear on the performance of the delayed sequentially implanted ear in pediatric patients. STUDY DESIGN: Retrospective case series review. SETTING: Outpatient Cochlear Implant (CI) center. PATIENTS: Congenitally deaf children who underwent unilateral implant at various ages followed by sequential implant of the contralateral ear with various delays were enrolled in the study...
June 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
Sara Naji-Tabasi, Seyed Mohammad Ali Razavi
BSG is composed of two major fractions with different molecular weight: PER-BSG (5980kgmol(-1)) and SUPER-BSG (1045kgmol(-1)). In the present work, the emulsifying and foaming properties of BSG and its fractions were investigated as a function of molecular weight, chain flexibility and physicochemical features (protein and acid uronic content). BSG prevented creaming of emulsion for 4 weeks. This high stabilization may be related to formation a solid-like structure and viscoelastic film of BSG around oil droplets which protected oil droplets against aggregation...
September 20, 2016: Carbohydrate Polymers
Birgitte Moen, Kristi Henjum, Ingrid Måge, Svein Halvor Knutsen, Ida Rud, Ragna Bogen Hetland, Jan Erik Paulsen
Foods naturally high in dietary fiber are generally considered to protect against development of colorectal cancer (CRC). However, the intrinsic effect of dietary fiber on intestinal carcinogenesis is unclear. We used azoxymethane (AOM) treated A/J Min/+ mice, which developed a significantly higher tumor load in the colon than in the small intestine, to compare the effects of dietary inulin (IN), cellulose (CE) or brewers spent grain (BSG) on intestinal tumorigenesis and cecal microbiota. Each fiber was tested at two dose levels, 5% and 15% (w/w) content of the AIN-93M diet...
2016: PloS One
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