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Wilson R Freitas, Luis Vicente Franco Oliveira, Eduardo A Perez, Elias J Ilias, Carina P Lottenberg, Anderson S Silva, Jessica J Urbano, Manoel C Oliveira, Rodolfo P Vieira, Marcelo Ribeiro-Alves, Vera L S Alves, Paulo Kassab, Fabio R Thuler, Carlos A Malheiros
BACKGROUND: Obesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects...
March 1, 2018: Obesity Surgery
Sarmed S Sami, Hasan N Haboubi, Yeng Ang, Philip Boger, Pradeep Bhandari, John de Caestecker, Helen Griffiths, Rehan Haidry, Hans-Ulrich Laasch, Praful Patel, Stuart Paterson, Krish Ragunath, Peter Watson, Peter D Siersema, Stephen E Attwood
These are updated guidelines which supersede the original version published in 2004. This work has been endorsed by the Clinical Services and Standards Committee of the British Society of Gastroenterology (BSG) under the auspices of the oesophageal section of the BSG. The original guidelines have undergone extensive revision by the 16 members of the Guideline Development Group with representation from individuals across all relevant disciplines, including the Heartburn Cancer UK charity, a nursing representative and a patient representative...
February 24, 2018: Gut
Xingqi Zou, Lei Jin, Dandan Jiang, Yu Zhang, Guoxing Chen, Zhiliang Xia, Zongliang Huo
In this work, the GAA (Gate All Around) L-Shaped bottom select transistor (BSG) in 3D NAND Flash Memory has been investigated. Different methods are proposed to optimize its performance from viewpoints of process and structure. BSG in 3D NAND is a novel device structure with two connected transistors: one is horizontal MOSFET (regarded as convention MOSFET) and one is vertical MOSFET (regarded as GAA transistor). With implant dose increasing in vertical channel, BSG Vth has much more tighter Vt distribution, which is beneficial for boosting potential improvement and program disturbance suppression...
August 1, 2018: Journal of Nanoscience and Nanotechnology
Abdulrahman Abdullah Albatly, Adnan Taleb Alsamarah, Abdulrahman Alhawas, Patrick Veit-Haibach, Alfred Buck, Paul Stolzmann, Irene A Burger, Spyros S Kollias, Martin W Huellner
PURPOSE: To investigate 18 F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). MATERIALS AND METHODS: FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUV max , TBR, and time activity curves of FET-PET were calculated. RESULTS: Progressive gliomas had higher SUV max (3.57 ± 1.47 vs...
February 8, 2018: Clinical Imaging
Toshihide Matsumoto, Ryo Nagashio, Shinichiro Ryuge, Satoshi Igawa, Makoto Kobayashi, Eriko Fukuda, Naoki Goshima, Masaaki Ichinoe, Shi-Xu Jiang, Yukitoshi Satoh, Noriyuki Masuda, Yoshiki Murakumo, Makoto Saegusa, Yuichi Sato
We established the KU-Lu-8 monoclonal antibody (MoAb) using a lung cancer cell line as an antigen and a random immunization method. The KU-Lu-8 MoAb recognizes basigin (BSG), which is a transmembrane-type glycoprotein that is strongly expressed on the cell membranes of lung cancer cells. This study aimed to clarify the relationships between BSG expression and clinicopathological parameters and determine the prognostic significance of BSG expression in pulmonary adenocarcinoma (AC) patients. To evaluate the significance of BSG expression in lung cancer, we immunohistochemically analyzed 113 surgically resected pulmonary adenocarcinomas, and the associations between BSG expression and various clinicopathological parameters were evaluated...
February 12, 2018: Pathology International
J Steiner, K Franke, M Kießling, S Fischer, S Töpfl, V Heinz, T Becker
Brewer's spent grain (BSG) constitutes various valuable carbohydrates that may contribute to a healthy diet. These components may be obtained from BSG via hydrothermal treatment (HT), a procedure for dissolving water-inextricable carbohydrates. The objective of this study was to investigate HT as an environmentally friendly technology for extracting high-molecular-weight fiber with proven beneficial effects on human health. Cellulose, β-glucan, and arabinoxylan (AX) served as model substances and were subjected to auto-hydrolysis at different temperatures and reaction times...
March 15, 2018: Carbohydrate Polymers
Mursalin Sajib, Peter Falck, Roya R R Sardari, Sindhu Mathew, Carl Grey, Eva Nordberg Karlsson, Patrick Adlercreutz
Brewer's spent grain (BSG) accounts for around 85% of the solid by-products from beer production. BSG was first extracted to obtain water-soluble arabinoxylan (AX). Using subsequent alkali extraction (0.5 M KOH) it was possible to dissolve additional AX. In total, about 57% of the AX in BSG was extracted with the purity of 45-55%. After comparison of nine xylanases, Pentopan mono BG, a GH11 enzyme, was selected for hydrolysis of the extracts to oligosaccharides with minimal formation of monosaccharides. Growth of Bifidobacterium adolescentis (ATCC 15703) was promoted by the enzymatic hydrolysis to arabinoxylooligosaccharides, while Lactobacillus brevis (DSMZ 1264) utilized only unsubstituted xylooligosaccharides...
January 11, 2018: Journal of Biotechnology
Yashar Moharamzad, Morteza Sanei Taheri, Farhad Niaghi, Elham Shobeiri
Objective The objective of this article is to investigate the association between specific MR imaging findings and histopathologic grading (low-grade vs. high-grade) of brainstem gliomas (BSGs). Methods Sixty-two males and 34 females (mean (standard deviation, SD) age of 24.61 (17.20) years, range = 3 to 70 years) with histologically diagnosed BSG underwent conventional 1.5 T MR imaging, which included T1-weighted (T1W), T2W, and post-contrast T1W sequences. There were 39 children (mean age of 9.38 years) and 57 adults (mean age of 35 years)...
January 1, 2017: Neuroradiology Journal
Philip N Newsome, Rob Cramb, Suzanne M Davison, John F Dillon, Mark Foulerton, Edmund M Godfrey, Richard Hall, Ulrike Harrower, Mark Hudson, Andrew Langford, Anne Mackie, Robert Mitchell-Thain, Karen Sennett, Nicholas C Sheron, Julia Verne, Martine Walmsley, Andrew Yeoman
These updated guidelines on the management of abnormal liver blood tests have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines, which this document supersedes, were written in 2000 and have undergone extensive revision by members of the Guidelines Development Group (GDG). The GDG comprises representatives from patient/carer groups (British Liver Trust, Liver4life, PBC Foundation and PSC Support), elected members of the BSG liver section (including representatives from Scotland and Wales), British Association for the Study of the Liver (BASL), Specialist Advisory Committee in Clinical Biochemistry/Royal College of Pathology and Association for Clinical Biochemistry, British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN), Public Health England (implementation and screening), Royal College of General Practice, British Society of Gastrointestinal and Abdominal Radiologists (BSGAR) and Society of Acute Medicine...
January 2018: Gut
Can Özbay, Fatih Kemal Soy, Erkan Kulduk, Riza Dundar, Ahmet Yükkaldiran, Osman Kadir Güler, Ertan Koç
Many techniques and graft materials have been used for the reconstruction of the tympanic membrane. We conducted a retrospective study to compare anatomic and functional outcomes of type 1 tympanoplasty that we performed with boomerang-shaped chondroperichondrial cartilage grafts (BSGs) and shield-shaped chondroperichondrial cartilage grafts (SSGs) in pediatric patients. Our study population was made up 121 patients-61 boys and 60 girls, aged 7 to 16 years (mean: 12.4)-who had undergone a type 1 tympanoplasty...
October 2017: Ear, Nose, & Throat Journal
Li Gao, Jin-Cai Zhong, Wen-Ting Huang, Yi-Wu Dang, Min Kang, Gang Chen
BACKGROUND: Though basigin (BSG) was reported to be overexpressed in nasopharyngeal carcinoma (NPC) and correlate with the development of NPC, the molecular basis of BSG in NPC remained elusive. The aim of the research was to investigate BSG expression in NPC and the potential molecular mechanism underlying it. MATERIALS AND METHODS: BSG expression in NPC tissues was detected with immunohistochemistry. Chi-square test, Kruskal-Wallis test and Spearman correlation test were performed to examine the relationship between BSG expression and the clinico-pathological features as well as EGFR and P-53 expression in NPC...
2017: American Journal of Translational Research
Sampa Maiti, Gorka Gallastegui, Gayatri Suresh, Saurabh Jyoti Sarma, Satinder Kaur Brar, Patrick Drogui, Yann LeBihan, Gerardo Buelna, Mausam Verma, Carlos Ricardo Soccol
Brewery industry liquid waste (BLW), brewery spent grain (BSG), apple pomace solid wastes (APS), apple pomace ultrafiltration sludge (APUS) and starch industry wastewater (SIW) have been considered as substrates to produce biobutanol. Efficiency of hydrolysis techniques tested to produce fermentable sugars depended on nature of agro-industrial wastes and process conditions. Acid-catalysed hydrolysis of BLW and BSG gave a total reducing sugar yield of 0.433 g/g and 0.468 g/g respectively. Reducing sugar yield from microwave assisted hydrothermal method was 0...
October 5, 2017: Bioresource Technology
Sarah M Theodoroff, Garnett P McMillan, Tara L Zaugg, Megan Cheslock, Chan Roberts, James A Henry
Purpose: The aim of this study was to determine if a customized stimulus from the Otoharmonics Levo System reduces tinnitus perceptions and reactions for people with bothersome tinnitus. Method: Sixty participants were randomized to 1 of 3 groups that used sound therapy devices during sleep that differed in their acoustic stimulus: (a) tinnitus-matched (TM), (b) noise stimulus (NS), and (c) bedside sound generator (BSG). Outcome measures were the Tinnitus Functional Index (TFI), numeric rating scale of tinnitus loudness, and tinnitus loudness match...
October 31, 2017: American Journal of Audiology
Usheer Kanjee, Christof Grüring, Mudit Chaand, Kai-Min Lin, Elizabeth Egan, Jale Manzo, Patrick L Jones, Tiffany Yu, Robert Barker, Michael P Weekes, Manoj T Duraisingh
During malaria blood-stage infections, Plasmodium parasites interact with the RBC surface to enable invasion followed by intracellular proliferation. Critical factors involved in invasion have been identified using biochemical and genetic approaches including specific knockdowns of genes of interest from primary CD34(+) hematopoietic stem cells (cRBCs). Here we report the development of a robust in vitro culture system to produce RBCs that allow the generation of gene knockouts via CRISPR/Cas9 using the immortal JK-1 erythroleukemia line...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
Mary Anne Mukasafari, Mary K Ambula, Callixte Karege, Anthony M King'ori
Nutrient composition of brewers' spent grains (BSG) from two industries and sow and weaner meal (SWM) were different (p < 0.05). In completely randomised design (CRD), thirty (30) Landrace x Pietrain crosses 35 to 40 ± 5 kg were randomly allocated to 10 pens each with 3 pigs based on the initial weight. Five diets were assigned to pig, where BSG replaced SWM at 0% (T1), 25% (T2), 50% (T3), 75% (T4) and 100% (T5) on DM basis. Daily feed intake and weekly live weight, feed conversion ratio (FCR) and the net profit were recorded for 42 days...
October 23, 2017: Tropical Animal Health and Production
Marc Weidenbusch, Severin Rodler, Shangqing Song, Simone Romoli, Julian A Marschner, Franziska Kraft, Alexander Holderied, Santosh Kumar, Shrikant R Mulay, Mohsen Honarpisheh, Satish Kumar Devarapu, Maciej Lech, Hans-Joachim Anders
Notch and Interleukin-22 signaling are known to regulate tissue homeostasis and response to injury in humans and mice, and the induction of endogenous arylhydrocarbon receptor ligands through Notch links the two pathways in a hierarchical fashion. However, in adults the species-, organ- and injury-specific gene expression of the Notch-AhR-IL22 axis components is unknown. We therefore performed gene expression profiling of DLL1, DLL3, DLL4, DLK1, DLK2, JAG1, JAG2, Notch1, Notch2, Notch3, Notch4, ADAM17/TACE, PSEN1, BSG/CD147, RBP-J, HES1, HES5, HEY1, HEYL, AHR, ARNT, ARNT2, CYP1A1, CYP24A1, IL22, IL22RA1, IL22RA2, IL10RB, and STAT3 under homeostatic conditions in 10 mature murine and human organs...
October 20, 2017: Bioscience Reports
Kimio Satoh
Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory cells, activated platelets, and cardiac fibroblasts in response to oxidative stress. Excessive and continuous activation of the RhoA/Rho-kinase system promotes the secretion of CyPA, resulting in the development of multiple cardiovascular diseases. Basigin (Bsg), a transmembrane glycoprotein that activates matrix metalloproteinases, is an extracellular receptor for CyPA that promotes cell proliferation and inflammation. Thus, the CyPA/Bsg system is potentially a novel therapeutic target for cardiovascular diseases...
October 6, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
Luyi Ye, Chen Wang, Qixiu Yang, Ziyan Zhu
OBJECTIVE: To investigate whether miR-492 is involved in the post-transcriptional regulation of OK blood group antigen expression on red blood cells. METHODS: Two 3'-UTR fragments of the BSG gene were synthesized with a chemical method, which respectively encompassed the BSG rs8259 TT or BSG rs8259 AA sites. The fragments were added with Xho I and Not I restriction enzyme cutting sites at both ends and cloned into a pUC57 vector, which in turn was constructed into a psiCHECK-2 vector and verified by sequencing...
October 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
Claire Bougrier, Delphine Dognin, Cécile Laroche, Valérie Gonzalez, Dalel Benali-Raclot, Jesús Andrés Cacho Rivero
The current study evaluates and compares the stability of anaerobic digestion of Brewery Spent Grains (BSG) with and without addition of nutrients. Based on the composition of the BSG two levels of nutrients addition were defined. Control reactor, without addition of nutrients, showed signs of instability after 3months of operation and collapsed. On the contrary, supplemented reactors led to a COD removal rate of 60% and a methane production of VSadded. According to these results, it was possible to define an additive solution adapted to BSG degradation...
September 2, 2017: Bioresource Technology
K Stejskalova, Z Bayerova, J Futas, K Hrazdilova, M Klumplerova, J Oppelt, P Splichalova, G Di Guardo, S Mazzariol, C E Di Francesco, G Di Francesco, G Terracciano, R-M Paiu, T D Ursache, D Modry, P Horin
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena...
September 11, 2017: HLA
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