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Guillaume Bonnaud, Audrey Haennig, Jonathan Levy, Nicolas Sigur, Alain Ledit, Philippe Cabarrot, Patrick Faure, Catherine Auzimour, Asmaa El Atmani, Xavier Hebuterne, Laurent Peyrin-Biroulet
BACKGROUND: Recently, treatment algorithms were developed in France additionally to ECCO recommendations that should be used as reference for ulcerative colitis (UC) management. Nevertheless, their implementation in clinical practice remains challenging. AIMS: To evaluate the prevalence of the use of these UC management algorithms in 127 patients followed by private gastroenterologists. METHODS: Charts of all UC patients seen during the year 2015 (n=127) by 10 gastroenterologists were reviewed...
September 3, 2016: Digestive and Liver Disease
M A Lagares, R Ecco, Nrs Martins, Ljc Lara, Jsr Rocha, Dar Vilela, V M Barbosa, P F Mantovani, Jfv Braga, I S Preis, V A Gheller, P C Cardeal, N C Baião
The objective of this study was to detect the reasons of rooster's fertility decrease at 50 weeks of age. Therefore, the reproductive system of broiler breeder roosters was laparoscopic, macroscopic and histopathology evaluated, and a comparison of the anatomical aspect with the sperm analysis and birds' age was realized. Cobb roosters (n = 59) were distributed into two groups (30 and 50 weeks). Evaluations were performed with laparoscopy, macroscopy and histopathology, and seminal quality, blood serum testosterone concentration and weight were also determined...
September 30, 2016: Reproduction in Domestic Animals, Zuchthygiene
Paolo Gionchetti, Axel Dignass, Silvio Danese, Fernando José Magro Dias, Gerhard Rogler, Péter Laszlo Lakatos, Michel Adamina, Sandro Ardizzone, Christianne J Buskens, Shaji Sebastian, Silvio Laureti, Gianluca M Sampietro, Boris Vucelic, C Janneke van der Woude, Manuel Barreiro-de Acosta, Christian Maaser, Francisco Portela, Stephan R Vavricka, Fernando Gomollón
This paper is the second in a series of two publications relating to the European Crohn's and Colitis Organisation (ECCO) evidence based consensus on the diagnosis and management of Crohn's disease and concerns the surgical management of Crohn's disease as well as special situations including management of perianal Crohn's disease and extraintestinal manifestations. Diagnostic approaches and medical management of Crohn's disease of this ECCO Consensus are covered in the first paper [Gomollon F et al JCC 2016]...
September 22, 2016: Journal of Crohn's & Colitis
Fernando Gomollón, Axel Dignass, Vito Annese, Herbert Tilg, Gert Van Assche, James O Lindsay, Laurent Peyrin-Biroulet, Garret J Cullen, Marco Daperno, Torsten Kucharzik, Florian Rieder, Sven Almer, Alessandro Armuzzi, Marcus Harbord, Jost Langhorst, Miquel Sans, Yehuda Chowers, Gionata Fiorino, Pascal Juillerat, Gerassimos J Mantzaris, Fernando Rizzello, Stephan Vavricka, Paolo Gionchetti
This paper is the first in a series of two publications relating to the European Crohn's and Colitis Organisation (ECCO) evidence based consensus on the diagnosis and management of Crohn's disease and concerns the methodology of the consensus process, classification, diagnosis and medical management of active and quiescent Crohn's disease. Surgical management as well as special situations including management of perianal Crohn's disease of this ECCO Consensus are covered in a subsequent second paper [Gionchetti et al JCC 2016]...
September 22, 2016: Journal of Crohn's & Colitis
Domenico Corica, Claudio Romano
The incidence of inflammatory bowel disease (IBD) has increased steadily worldwide, both in adult and in children; approximately 25% of IBD patients are diagnosed before the age of 18. The natural history of IBD is usually more severe in children than in adults, and can be associated with linear growth impairment, delayed puberty onset, reduced bone mass index, malnutrition, and the need for surgery. Biological therapies, especially blocking tumor necrosis factor-α (TNFα), have radically modified the treatment strategies and disease course of IBD in children...
September 15, 2016: Journal of Clinical Gastroenterology
Silvio Danese, Elmer Schabel, Johan Masure, Scott Plevy, Stefan Schreiber
The role of placebo in clinical trials for drug development in inflammatory bowel disease [IBD] was the topic of a panel discussion held during the 10th Congress of the European Crohn's and Colitis Organisation [ECCO], in Barcelona, Spain, in 2015. Panellists discussed a number of issues around placebo-controlled trials in IBD, noting issues such as difficulties with recruitment, leading to less then representative patient populations in clinical studies. It was noted that, whereas the easiest answer may be to drop placebo, it is much more complicated than that...
September 2016: Journal of Crohn's & Colitis
Konstantinos H Katsanos, Eugeni Domènech, Jean-François Rahier, Uri Kopylov, Gionata Fiorino, Gerhard Rogler, Edouard Louis, Shomron Ben-Horin
No abstract text is available yet for this article.
July 19, 2016: Journal of Crohn's & Colitis
Juliana Fortes Vilarinho Braga, Nathalie Katy Chanteloup, Angélina Trotereau, Sylvie Baucheron, Rodrigo Guabiraba, Roselene Ecco, Catherine Schouler
BACKGROUND: Locomotor disorders and infections by Escherichia coli represent major concerns to the poultry industry worldwide. Avian pathogenic E. coli (APEC) is associated with extraintestinal infections leading to respiratory or systemic disease known as colibacillosis. The most common lesions seen in cases of colibacillosis are perihepatitis, airsacculitis, pericarditis, peritonitis/salpingitis and arthritis. These diseases are responsible for significant economic losses in the poultry industry worldwide...
2016: BMC Veterinary Research
Theodor Landis
Our brain has two hemispheres that specialize in different jobs-the right side processes spatial and temporal information, and the left side controls speech and language. How these two sides come together to create one mind is explained by pioneering neuroscientist Michael Gazzaniga in his new book, Tales from Both Sides of the Brain : A Life in Neuroscience (Ecco/Harper Collins, 2015). Gazzaniga is director of the SAGE Center for the Study of the Mind at the University of California, Santa Barbara, and a Dana Alliance member...
November 2015: Cerebrum: the Dana Forum on Brain Science
Franco Scaldaferri, Viviana Gerardi, Francesca Mangiola, Loris Riccardo Lopetuso, Marco Pizzoferrato, Valentina Petito, Alfredo Papa, Jovana Stojanovic, Andrea Poscia, Giovanni Cammarota, Antonio Gasbarrini
Ulcerative colitis (UC) is a chronic inflammatory disease, whose etiology is still unclear. Its pathogenesis involves an interaction between genetic factors, immune response and the "forgotten organ", Gut Microbiota. Several studies have been conducted to assess the role of antibiotics and probiotics as additional or alternative therapies for Ulcerative Colitis. Escherichia coli Nissle (EcN) is a nonpathogenic Gram-negative strain isolated in 1917 by Alfred Nissle and it is the active component of microbial drug Mutaflor(®) (Ardeypharm GmbH, Herdecke, Germany and EcN, Cadigroup, In Italy) used in many gastrointestinal disorder including diarrhea, uncomplicated diverticular disease and UC...
June 28, 2016: World Journal of Gastroenterology: WJG
Juliana Fortes Vilarinho Braga, Camila Costa Silva, Maurício de Paula Ferreira Teixeira, Nelson Rodrigo da Silva Martins, Roselene Ecco
Vertebral osteomyelitis (VO) is a worldwide emerging disease that affects broilers. The objective of this study was to determine the frequency and aetiology of VO in broilers in a highly productive broiler region. For this, 608 broilers with locomotory problems were analysed from 18 farms. Clinical signs were recorded, necropsy was performed and samples were collected from vertebral bodies with gross changes for molecular and histopathological analysis and for bacterial isolation. From broilers with locomotory changes, 5...
October 6, 2016: Avian Pathology: Journal of the W.V.P.A
Sue S Yom, Apar K Ganti, Andreas Dietz
Scientific investigation is extremely active in the treatment, management, and optimization of therapies for patients with head and neck cancer. These issues have undergone recent rapid evolution in response to a changing epidemiology based on an increasing proportion of HPV-associated oropharyngeal cancer with advances in multimodality technologies to improve outcomes and reduce toxicity. Choices of definitive treatment of various anatomic subsites are being refined, balancing the relative indications and advantages of surgery or chemoradiation-based strategies...
2016: American Society of Clinical Oncology Educational Book
Clément Bonnet, Guillaume Beinse, Luc Cabel, Delphine Cochereau, Pernelle Lavaud, Pauline Rochefort, Emeline Tabouret, Anthony Turpin, Loic Verlingue, Cécile Vicier, Christophe Massard
The ESMO/ECC congress (European Society for Medical Oncology/European Cancer Congress) took place in Vienna, Austria, September 25-29. The main topic of the conference was immunotherapies especially in advanced kidney cancer with nivolumab in phase III and in metastatic lung cancer with atezolizumab in phase II. Targeted therapies were also highlighted with cabozantinib proposed in advanced renal cancer or everolimus in differenciated neuroendocrine tumors grade 1 or 2. Furthermore the current challenges remain unchanged: improving patients' care through better selection and finding biomarkers using simple samples (blood or urine)...
June 2016: Bulletin du Cancer
Foteini Chatzinasiou, Dimitrios Polymeros, Maro Panagiotou, Konstadinos Theodoropoulos, Dimitrios Rigopoulos
Pyoderma gangrenosum (PG) is a rare ulcerative skin disease, part of the spectrum of neutrophilic and auto-inflammatory dermatoses. Its pathogenesis is unknown, although immune pathways have been implicated. Lesion biopsies show a predominantly neutrophilic infiltrate. The incidence of PG is uncertain, but it is estimated to be 3-10 per million per year, occurring at any age but most commonly between 20 and 50 years with a possible slightly higher incidence in women. Approximately 50% of patients with PG also have another disease associated with PG...
April 2016: Acta Dermatovenerologica Croatica: ADC
Silvio Danese, Gionata Fiorino, Pierre Michetti
BACKGROUND: In 2013, a ECCO survey showed that a minority of IBD specialists was aware and confident about the benefits and issues of biosimilars. We aimed to look at the evolution of IBD specialists' thinking about biosimilars one year after they became available in the European Union. METHODS: A 14-question anonymous survey was posted in the ECCO website. Members voluntarily participated in response to ECCO office invitations to participate in their surveys. Information on gender, job position, country, experience with biologics also were collected...
April 25, 2016: Journal of Crohn's & Colitis
Timothy J Price, Subotheni Thavaneswaran, Matthew Burge, Eva Segelov, Daniel G Haller, Cornelis Ja Punt, Dirk Arnold, Christos S Karapetis, Niall C Tebbutt, Nick Pavlakis, Peter Gibbs, Jeremy D Shapiro
The treatment of metastatic CRC (mCRC) has evolved over the last 20 years, from fluoropyrimidines alone to combination chemotherapy and new biologic agents. Median overall survival is now over 24 months for RAS mutated (MT) patients and over 30 months for RAS wild-type (WT) patients. However, there are subgroups of patients with BRAF V600E MT CRC who have a significantly poorer outlook. Newer treatment options are also being explored in select subgroups of patients (anti-HER 2 in HER2 positive mCRC and immunotherapy in patients with defective mismatch repair (dMMR))...
May 2016: Expert Review of Anticancer Therapy
Gabriela Ecco, Marco Cassano, Annamaria Kauzlaric, Julien Duc, Andrea Coluccio, Sandra Offner, Michaël Imbeault, Helen M Rowe, Priscilla Turelli, Didier Trono
KRAB-containing zinc finger proteins (KRAB-ZFPs) are early embryonic controllers of transposable elements (TEs), which they repress with their cofactor KAP1 through histone and DNA methylation, a process thought to result in irreversible silencing. Using a target-centered functional screen, we matched murine TEs with their cognate KRAB-ZFP. We found the paralogs ZFP932 and Gm15446 to bind overlapping but distinguishable subsets of ERVK (endogenous retrovirus K), repress these elements in embryonic stem cells, and regulate secondarily the expression of neighboring genes...
March 21, 2016: Developmental Cell
Christopher J Playfoot, Ian R Adams
Transposable element (TE) silencing is initiated early in mammalian development and maintained during somatic differentiation. Reporting in this issue of Developmental Cell, Ecco et al. (2016) show that in somatic tissues, TE regulation, and its subsequent effect on host gene transcription, is dynamic rather than locked in a silent state.
March 21, 2016: Developmental Cell
Dana Lucia Stanculeanu, Daniela Mosoiu, Alecu Mihnea, Laurentiu Simion
Ovarian cancer represents the 4-th reason of cancer related death in women, the majority of patients being diagnosed in advanced stages of the disease, (III-IV). The loco-regional advanced ovarian cancer should be considered a chronic disease, with multiple evolutionary relapses and where the adjuvant treatment is mandatory.The treatment of the disease is multidisciplinary and the oncologist is the centerpiece.
January 2016: Chirurgia
Turid Hammer, Kári R Nielsen, Pia Munkholm, Johan Burisch, Elsebeth Lynge
BACKGROUND AND AIMS: Inflammatory bowel diseases [IBDs] include Crohn's disease [CD], ulcerative colitis [UC], and IBD unclassified [IBDU]. In 2010 and 2011, the ECCO-EpiCom study found the worldwide highest incidence of inflammatory bowel disease [IBD] in the Faroe Islands: 83 per 100 000 [European Standard Population, ESP]. The present study assessed the long-term time trends in IBD incidence in the Faroese population. METHODS: In this population-based study, data were retrieved from the National Hospital of the Faroe Islands and included all incident cases of CD, UC, and IBDU diagnosed between July 1960 and July 2014...
August 2016: Journal of Crohn's & Colitis
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