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https://www.readbyqxmd.com/read/29726935/evolving-role-of-ibd-surgery
#1
W A Bemelman
No abstract text is available yet for this article.
May 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29685190/differences-in-epidemiological-features-between-ulcerative-colitis-and-crohn-s-disease-the-early-life-programmed-versus-late-dysbiosis-hypothesis
#2
Laurent Beaugerie, Ebbe Langholz, Nynne Nyboe-Andersen, Bénédicte Pigneur, Harry Sokol
It is increasingly admitted that Crohn's disease and ulcerative colitis, the two entities of inflammatory bowel disease, are initiated and reactivated by environmental factors in genetically susceptible hosts, and result from aberrant immune response to specific intestinal microbes, in the context of altered composition of intestinal microbiota, called dysbiosis. We hypothesize that the role of the gut microbiota in Crohn's disease pathogenesis is linked to early-life abnormal crosstalk with the host immune system under construction...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29672874/review-article-novel-oral-targeted-therapies-in-inflammatory-bowel-disease
#3
REVIEW
J R White, F Phillips, T Monaghan, W Fateen, S Samuel, S Ghosh, G W Moran
BACKGROUND: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of medications that target specific genetic pathways found to be relevant in other immune mediated diseases. AIMS: To provide an overview of recent clinical trials for new generation oral targeted medications that may have a future role in IBD management...
April 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29596190/chapter-9-words-from-partner-societies
#4
Barbara Golden, Tom Stiris, Julián Panés, Leyla Namazova-Baranova, André Van Gossum, Heiner Boeing, Zulfiqar A Bhutta, Armando Madrazo, James E Heubi, Nezha Mouane, Paul Fockens, Berthold Koletzko
On the occasion of the 50th anniversary of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), its close partner associations submitted comments and felicitations which are presented here. These include words from the Latin American (LASPGHAN), North American (NASPGHAN) and Panarabian Societies (PASPGHAN) and the Commonwealth Association (CAPGHAN) of Paediatric Gastroenterology, Hepatology and Nutrition, the Federation of International Societies of Paediatric Gastroenterology, Hepatology and Nutrition (FISPGHAN), the European Academy of Pediatrics (EAP), the European Pediatric Association/Union of National Pediatric Societies (EPA-UNEPSA), the International Pediatric Association (IPA), the European Crohn's and Colitis Organisation (ECCO), European Society for Clinical Nutrition and Metabolism (ESPEN) , the Federation of European Nutrition Societies (FENS), and United European Gastroenterology (UEG)...
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29560697/dysplasia-in-inflammatory-bowel-disease
#5
REVIEW
A Driessen, E Macken, T Moreels, A Jouret-Mourin
Ulcerative colitis and Crohn's diseases are relapsing longstanding inflammatory bowel diseases, associated with an increased risk of developing colorectal cancer. Continuous surveillance is necessary to detect the preneoplastic lesions in an early stage. New endoscopic techniques have improved the diagnostic accuracy and have resulted in a new and more simplified classification system of the dysplastic lesions in the bowel. Histopathologically these lesions are very heterogenous, consisting of adenomatous, villous and the more recently discovered serrated dysplasia...
April 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29526343/-non-small-lung-cancer-ecco-esmo-congres-2017
#6
REVIEW
N Naqos, R Belbaraka, A El Omrani, M Khouchani
During the esmo congress that took place from 08 to 12 September 2017 in Madrid, non-small cell lung cancer (NSCLC) was the subject of various communications and posters. We selected the most innovative and most likely to change our daily practice These updates presented concerned both localized and metastatic lung cancers. For completely resected localized stages minimal monitoring by annual CT scan is recommended, in stage III after radio chemotherapy durvalumab treatment provides better progression-free survival (PFS)...
April 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29525468/ecco-essential-requirements-for-quality-cancer-care-for-melanoma-defining-how-to-organise-care
#7
EDITORIAL
Michel W Wouters
No abstract text is available yet for this article.
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29524550/ecco-an-error-correcting-comparator-theory
#8
Stefano Ghirlanda
Building on the work of Ralph Miller and coworkers (Miller and Matzel, 1988; Denniston et al., 2001; Stout and Miller, 2007), I propose a new formalization of the comparator hypothesis that seeks to overcome some shortcomings of existing formalizations. The new model, dubbed ecco for "Error-Correcting COmparisons," retains the comparator process and the learning of CS-CS associations based on contingency. ecco assumes, however, that learning of CS-US associations is driven by total error correction, as first introduced by Rescorla and Wagner (1972)...
March 8, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29509882/2nd-n-ecco-consensus-statements-on-the-european-nursing-roles-in-caring-for-patients-with-crohn-s-disease-or-ulcerative-colitis
#9
K Kemp, L Dibley, U Chauhan, K Greveson, S Jäghult, K Ashton, S Buckton, J Duncan, P Hartmann, N Ipenburg, L Moortgat, R Theeuwen, M Verwey, L Younge, A Sturm, P Bager
No abstract text is available yet for this article.
March 2, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29482634/individual-retrotransposon-integrants-are-differentially-controlled-by-kzfp-kap1-dependent-histone-methylation-dna-methylation-and-tet-mediated-hydroxymethylation-in-na%C3%A3-ve-embryonic-stem-cells
#10
Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli, Didier Trono
BACKGROUND: The KZFP/KAP1 (KRAB zinc finger proteins/KRAB-associated protein 1) system plays a central role in repressing transposable elements (TEs) and maintaining parent-of-origin DNA methylation at imprinting control regions (ICRs) during the wave of genome-wide reprogramming that precedes implantation. In naïve murine embryonic stem cells (mESCs), the genome is maintained highly hypomethylated by a combination of TET-mediated active demethylation and lack of de novo methylation, yet KAP1 is tethered by sequence-specific KZFPs to ICRs and TEs where it recruits histone and DNA methyltransferases to impose heterochromatin formation and DNA methylation...
February 26, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29458786/ecco-essential-requirements-for-quality-cancer-care-oesophageal-and-gastric-cancer
#11
REVIEW
William Allum, Florian Lordick, Maria Alsina, Elisabeth Andritsch, Ahmed Ba-Ssalamah, Marc Beishon, Marco Braga, Carmela Caballero, Fatima Carneiro, Fernando Cassinello, Jan Willem Dekker, Roberto Delgado-Bolton, Karin Haustermans, Geoffrey Henning, Bettina Hutter, József Lövey, Irena Štenglová Netíková, Radka Obermannová, Simon Oberst, Siri Rostoft, Tiina Saarto, Thomas Seufferlein, Sapna Sheth, Venetia Wynter-Blyth, Alberto Costa, Peter Naredi
BACKGROUND: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific type of cancer. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29458785/ecco-essential-requirements-for-quality-cancer-care-melanoma
#12
REVIEW
Michel W Wouters, Olivier Michielin, Esther Bastiaannet, Marc Beishon, Orlando Catalano, Veronique Del Marmol, Roberto Delgado-Bolton, Rémi Dendale, Maria Die Trill, Andrea Ferrari, Ana-Maria Forsea, Hannelore Kreckel, József Lövey, Gre Luyten, Daniela Massi, Peter Mohr, Simon Oberst, Philippe Pereira, João Paulo Paiva Prata, Piotr Rutkowski, Tiina Saarto, Sapna Sheth, Gilly Spurrier-Bernard, Meri-Sisko Vuoristo, Alberto Costa, Peter Naredi
BACKGROUND: ECCO essential requirements for quality cancer care (ERQCC) are explanations and descriptions of challenges, organisation and actions that are necessary to give high-quality care to patients who have a specific type of cancer. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29415255/validation-of-the-united-registries-for-clinical-assessment-and-research-ur-care-a-european-online-registry-for-clinical-care-and-research-in-inflammatory-bowel-disease
#13
Johan Burisch, Javier P Gisbert, Britta Siegmund, Dominik Bettenworth, Sandra Bohn Thomsen, Isabelle Cleynen, Anneline Cremer, Nik John Sheng Ding, Federica Furfaro, Michail Galanopoulos, Philip Christian Grunert, Jurij Hanzel, Tamara Knezevic Ivanovski, Eduards Krustins, Nurulamin Noor, Neil O'Morain, Iago Rodríguez-Lago, Michael Scharl, Julia Tua, Mathieu Uzzan, Nuha Ali Yassin, Filip Baert, Ebbe Langholz
Background: The "United Registries for Clinical Assessment and Research" (UR-CARE) database is an initiative of the European Crohn's and Colitis Organisation (ECCO) to facilitate daily patient care and research studies in inflammatory bowel disease (IBD). Herein, we sought to validate the database by using fictional case histories of patients with IBD that were to be entered by observers of varying experience in IBD. Methods: A total of 19 observers entered 5 patient case histories into the database...
February 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29398336/exclusive-enteral-nutrition-in-crohn-s-disease-evidence-and-practicalities
#14
REVIEW
James J Ashton, Joan Gavin, R Mark Beattie
Exclusive enteral nutrition (EEN) is the first line therapy for paediatric Crohn's disease, providing a complete nutritional feed whilst simultaneously inducing remission in up to 80% of cases. The effect of EEN on systemic/local intestinal immune function and subsequent inflammation (including barrier permeability, direct anti-inflammatory effects and cytokine signalling pathways), alongside changes in the microbiome (specific species and broad taxonomic shifts, functional changes) are becoming clearer, however the exact mechanism for induction of remission in Crohn's disease remains uncertain...
February 1, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29325112/autologous-haematopoietic-stem-cell-transplantation-ahsct-in-severe-crohn-s-disease-a-review-on-behalf-of-ecco-and-ebmt
#15
John A Snowden, Julián Panés, Tobias Alexander, Matthieu Allez, Sandro Ardizzone, Daan Dierickx, Jürgen Finke, Peter Hasselblatt, Chris Hawkey, Majid Kazmi, James O Lindsay, Francesco Onida, Azucena Salas, Riccardo Saccardi, Severine Vermeire, Montserrat Rovira, Elena Ricart
Despite the major recent progress in the treatment of Crohn's disease [CD], there is a subset of patients in whom the disease runs an aggressive course with progressive tissue damage requiring early and repeated surgical management. Increasing evidence supports sustained and profound improvement in gastrointestinal parameters and quality of life following high-dose immunosuppressive therapy and autologous haematopoietic stem cell transplantation [AHSCT] compared to standard therapy in this context. In addition, international transplant registry data reflect the use of AHSCT in CD outside of trials in selected patients...
March 28, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29029098/genital-granulomatosis-in-male-and-female-patients-with-crohn-s-disease-clinical-presentation-and-treatment-outcomes
#16
Frank Dederichs, Igor Iesalnieks, Malgrozata Sladek, Christos Tzivinikos, Richard Hansen, Carmen Muñoz, Paul Pavli, Mayran Cavicchi, Vered Abitbol, Jean-Francois Rahier, Stephan Vavricka, Konstantinos Katsanos, Eugeni Domènech
Background: Genital granulomatosis [GG] is a metastatic form of Crohn's disease [CD], characterised by granulomatous inflammation of the genital skin without contact with the gastrointestinal tract. Little is known about GG, as most publications are case reports or small series, and only sporadic in male cases. Methods and Aims: Cases of GG were retrospectively collected through the Collaborative Network For Exceptionally Rare case reports project of the European Crohn's and Colitis Organisation...
January 24, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28981623/european-crohn-s-and-colitis-organisation-topical-review-on-treatment-withdrawal-exit-strategies-in-inflammatory-bowel-disease
#17
Glen Doherty, Konstantinos H Katsanos, Johan Burisch, Matthieu Allez, Konstantinos Papamichael, Andreas Stallmach, Ren Mao, Ingrid Prytz Berset, Javier P Gisbert, Shaji Sebastian, Jaroslaw Kierkus, Loris Lopetuso, Edyta Szymanska, Edouard Louis
Clinically effective therapies now exist for remission maintenance in both ulcerative colitis [UC] and Crohn's Disease [CD]. For each major class of IBD medications [5-aminosalicyclates, immunomodulators, and biologic agents], used alone or in combination, there is a risk of relapse following reduction or cessation of treatment. A consensus expert panel convened by the European Crohn's and Colitis Organisation [ECCO] reviewed the published literature and agreed a series of consensus practice points. The objective of the expert consensus is to provide evidence-based guidance for clinical practice so that physicians can make informed decisions in partnership with their patients...
January 5, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28972682/presumed-post-traumatic-ocular-chondrosarcoma-with-intrathoracic-metastases-in-a-cat
#18
Matheus V L Moreira, Maria C de Andrade, Gustavo O Fulgêncio, Ingeborg M Langohr, Roselene Ecco
An indoor-only, 5-year-old, spayed female domestic shorthair cat presented for an ophthalmic examination of the left eye. An intraocular tumor with secondary glaucoma and blindness was diagnosed; the globe was enucleated and sent for histopathological examination. Gross examination revealed a solid white mass filling the entire vitreous space and replacing the iris and ciliary body. The lens and retina appeared to be similarly replaced by the neoplasm. Histological examination revealed a complete loss of the internal ocular structures, with a ruptured capsule as the only remnant of the lens within an extensive malignant mesenchymal neoplastic cell proliferation...
October 3, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28961811/research-gaps-in-diet-and-nutrition-in-inflammatory-bowel-disease-a-topical-review-by-d-ecco-working-group-dietitians-of-ecco
#19
Rotem Sigall-Boneh, Arie Levine, Miranda Lomer, Nicolette Wierdsma, Philip Allan, Gionata Fiorino, Simona Gatti, Daisy Jonkers, Jaroslaw Kierkus, Konstantinos H Katsanos, Silvia Melgar, Elif Saritas Yuksel, Kevin Whelan, Eytan Wine, Konstantinos Gerasimidis
Although the current doctrine of IBD pathogenesis proposes an interaction between environmental factors and gut microbiota in genetically susceptible individuals, dietary exposures have attracted recent interest and are, at least in part, likely to explain the rapid rise in disease incidence and prevalence. The D-ECCO working group along with other ECCO experts with expertise in nutrition, microbiology, physiology, and medicine reviewed the evidence investigating the role of diet and nutritional therapy in the onset, perpetuation, and management of IBD...
December 4, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28944071/prevalence-and-screening-for-anaemia-in-mild-to-moderate-crohn-s-disease-and-ulcerative-colitis-in-the-united-states-2010-2014
#20
Eboselume Akhuemonkhan, Alyssa Parian, Kay Miller, Stephen Hanauer, Susan Hutfless
BACKGROUND AND AIMS: Anaemia affects up to 74% patients with Crohn's disease (CD) and ulcerative colitis (UC) and is correlated with decreased quality of life. The European Crohn's and Colitis Organisation (ECCO) recommends at least annual screening for iron-deficiency anaemia. We aimed to determine the prevalence of anaemia, frequency of anaemia screening and factors associated with anaemia in a retrospective study of mild to moderate inflammatory bowel disease (IBD) in the USA. METHODS: Adults with at least two outpatient encounters for IBD between 2010 through 2014 who contributed laboratory information were identified from MarketScan, a US commercial claims database...
2017: BMJ Open Gastroenterology
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