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Mansour A Parsi, Shelby A Sullivan, Adam Goodman, Michael Manfredi, Udayakumar Navaneethan, Rahul Pannala, Zachary L Smith, Nirav Thosani, Subhas Banerjee, John T Maple
No abstract text is available yet for this article.
October 17, 2016: Gastrointestinal Endoscopy
Chuying Wang, Yumei Li, Xinxin Yang, Shengnan Bi, Yajie Zhang, Dong Han, Dafang Zhang
Tetramethylpyrazine (TMP) and astragaloside IV (AGS-IV) are herbal ingredients that have been demonstrated in animal models to limit infarct size and protect cardiomyocytes in the acute phase of myocardial infarction (MI), yet their long-term cardio-protective effects have not been evaluated. In the present study, TMP and/or ASG-IV were administrated to rats for 14 days after MI. Echocardiography revealed that the left ventricular (LV) dimensions and cardiac function was preserved in the MI rats with TMP and ASG-IV treatment, compared to untreated MI rats...
September 20, 2016: Journal of Cardiovascular Pharmacology
John B Ortolani, Daniel R Tershak, John J Ferrara, Charles J Paget
The American Society for Gastrointestinal Endoscopy (ASGE)/American College of Gastroenterology Task Force (ACGTF) on Quality in Endoscopy released updated quality benchmarks for colonoscopy in 2015. Our initial study concluded that surgery residents could perform safe and competent screening colonoscopy within a structured endoscopy curriculum. In this follow-up study, we sought to determine whether surgery residents could achieve the increased adenoma detection rate (ADR) benchmarks endorsed by the ASGE/ACGTF...
September 2016: American Surgeon
Bojana Milutinovic, Ninoslav Mitic, Jelena Roncevic, Sanja Goc, Miroslava Jankovic
This study was aimed at evaluation of the contribution of acid-soluble glycoproteins (ASG)/mucins and extracellular vesicles (EVs), yet unexplored components of human seminal plasma (hSP) to the complexity of its glycome. Gaining insight into the native presentation and distribution of glycans across hSP could help establish molecular environments supporting specific biological activities based on unique ligand capacities. Soluble and particulate fractions of hSP from healthy subjects were analyzed by gel filtration, electrophoresis, ion-exchange chromatography and a solid phase assay with immobilized charge-resolved glycospecies to test their reactivity with plant lectins, carbohydrate-binding antibodies and selected human lectins...
November 1, 2016: Archives of Biochemistry and Biophysics
Wei Li, Tingcai Cheng, Wenbo Hu, Zhangchuan Peng, Chun Liu, Qingyou Xia
Juvenile hormone (JH) regulates the insect growth and development. JH appears in the hemolymph bound by a specific glycoprotein, juvenile hormone-binding protein (JHBP), which serves as a carrier to release the hormone to target tissues and cells. However, JHBP family candidates, expression patterns, and functional implications are still unclear. In this study, we identified 41 genes-containing conserved JHBP domains distributed across eight chromosomes of the silkworm Bombyx mori. A phylogenetic tree showed that the silkworm JHBP (BmJHBP) genes could be classified into two major branches and four subfamilies...
September 8, 2016: Molecular Genetics and Genomics: MGG
Luke X Chong, Andrew Turpin, Allison M McKendrick
PURPOSE: To validate the performance of a new perimetric algorithm (Gradient-Oriented Automated Natural Neighbor Approach; GOANNA) in humans using a novel combination of computer simulation and human testing, which we call Artificial Scotoma Generation (ASG). METHODS: Fifteen healthy observers were recruited. Baseline conventional automated perimetry was performed on the Octopus 900. Visual field sensitivity was measured using two different procedures: GOANNA and Zippy Estimation by Sequential Testing (ZEST)...
September 2016: Translational Vision Science & Technology
Mihir S Wagh, Peter V Draganov
BACKGROUND AND AIM: Total aphagia from complete esophageal obstruction (CEO) can be seen in patients with head-neck or thoracic malignancies undergoing chemoradiation or surgery. Combined antegrade and retrograde endoscopy (via G-tube tract) is often performed for esophageal reconstruction but is limited by the length of the obstructed esophagus. We describe per-oral endoscopic tunneling for restoration of the esophagus (POETRE), for patients with longer segments of esophageal obstruction...
September 6, 2016: Gastrointestinal Endoscopy
Michael Mattie, Arthur Raitano, Kendall Morrison, Karen Morrison, Zili An, Linette Capo, Alla Verlinsky, Monica Leavitt, Jimmy Ou, Rossana Nadell, Hector Avina, Claudia Guevara, Faisal Malik, Ruth Moser, Steven Duniho, Jeffrey Coleman, Ying Li, Daniel S Pereira, Fernando Donate, Ingrid B J Joseph, Pia M Challita-Eid, Dennis Benjamin, David R Stover
Here we report the development of an antibody-drug conjugate, ASG-5ME, which targets the solute carrier receptor SLC44A4. SLC44A4 is a member of a family of putative choline transporters which we show to be markedly upregulated in a variety of epithelial tumors, most notably prostate and pancreatic cancer. SLC44A4 is normally expressed on the apical surface of secretory epithelial cells but in cancer we show expression is not restricted to the luminal surface in advanced and undifferentiated tumors. ASG-5ME consists of a human IgG2 anti-SLC44A4 antibody conjugated through a cleavable linker to the microtubule-disrupting agent, monomethylauristatin E...
August 22, 2016: Molecular Cancer Therapeutics
Vinay Chandrasekhara, Mouen A Khashab, V Raman Muthusamy, Ruben D Acosta, Deepak Agrawal, David H Bruining, Mohamad A Eloubeidi, Robert D Fanelli, Ashley L Faulx, Suryakanth R Gurudu, Shivangi Kothari, Jenifer R Lightdale, Bashar J Qumseya, Aasma Shaukat, Amy Wang, Sachin B Wani, Julie Yang, John M DeWitt
No abstract text is available yet for this article.
August 18, 2016: Gastrointestinal Endoscopy
Xiou Cao, Alejandro Aballay
The innate immune system is the front line of host defense against microbial infections, but its rapid and uncontrolled activation elicits microbicidal mechanisms that have deleterious effects [1, 2]. Increasing evidence indicates that the metazoan nervous system, which responds to stimuli originating from both the internal and the external environment, functions as a modulatory apparatus that controls not only microbial killing pathways but also cellular homeostatic mechanisms [3-5]. Here we report thatĀ dopamine signaling controls innate immune responses through a D1-like dopamine receptor, DOP-4, in Caenorhabditis elegans...
September 12, 2016: Current Biology: CB
Lutz Foucar
CASS [Foucar etĀ al. (2012). Comput. Phys. Commun. 183, 2207-2213] is a well established software suite for experiments performed at any sort of light source. It is based on a modular design and can easily be adapted for use at free-electron laser (FEL) experiments that have a biological focus. This article will list all the additional functionality and enhancements of CASS for use with FEL experiments that have been introduced since the first publication. The article will also highlight some advanced experiments with biological aspects that have been performed...
August 1, 2016: Journal of Applied Crystallography
Chad P Ammar, Sebastian Larion, Sadaf S Ahanchi, Kedar S Lavingia, David J Dexter, Jean M Panneton
BACKGROUND: An anatomic severity grading (ASG) score for primary descending thoracic aortic aneurysms (DTAs) was developed. The objective of this study was to determine if an ASG score cutoff value for DTAs is predictive of procedural complexity, aortic-related reinterventions, and mortality in patients who undergo thoracic endovascular aortic repair (TEVAR). METHODS: A retrospective review from 2008 to 2013 of patient records was conducted of all consecutive patients who underwent TEVAR for a primary DTA...
October 2016: Journal of Vascular Surgery
Suryakanth R Gurudu, David H Bruining, Ruben D Acosta, Mohamad A Eloubeidi, Ashley L Faulx, Mouen A Khashab, Shivangi Kothari, Jenifer R Lightdale, V Raman Muthusamy, Julie Yang, John M DeWitt
No abstract text is available yet for this article.
June 30, 2016: Gastrointestinal Endoscopy
Kang Xie, Xin Wang, Huifang Chen, Yi Li, Qianru Song, Ping Zhao
The silk gland of silkworm is the organ of silk protein synthesis and secretion. According to the morphological and functional differences, silk gland can be divided into anterior silk gland (ASG), middle silk gland (MSG) and posterior silk gland (PSG). ASG is the place for silk proteins conformation changes although it cannot synthetize silk proteins. ASG has narrow luminal structures and rigid wall which consists of chitin and cuticle proteins so that it can provide the shearing force which plays an important role in the silk protein conformation changes...
January 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Mouen A Khashab, Saowanee Ngamruengphong, David Carr-Locke, Amol Bapaye, Petros C Benias, Sam Serouya, Shivangi Dorwat, Dalton M Chaves, Everson Artifon, Eduardo G de Moura, Vivek Kumbhari, Yamile Haito Chavez, Majidah Bukhari, Gulara Hajiyeva, Amr Ismail, Yen-I Chen, Hyunsoo Chung
BACKGROUND AND AIMS: Gastric peroral endoscopic myotomy (G-POEM) has been recently reported as minimally invasive therapy for gastroparesis. The aims of this study were to report the first multicenter experience with G-POEM and assess the efficacy and safety of this novel procedure for gastroparetic patients with symptoms refractory to medical therapy. PATIENTS AND METHODS: All patients with gastroparesis who underwent endoscopic pyloromyotomy (G-POEM) at 5 medical centers were included...
June 25, 2016: Gastrointestinal Endoscopy
Mohammad F Madhoun, Gregory A Cote, Sushil K Ahlawat, Nuzhat A Ahmad, Jonathan M Buscaglia, Audrey H Calderwood, Seth Crockett, Dayna S Early, Ferga C Gleeson, Suryakanth R Gurudu, Thomas F Imperiale, Julia J Liu, Patrick Mosler, Rahul Pannala, Patrick R Pfau, Joseph Romagnuolo, Jewel Samadder, Amrita Sethi, Amandeep K Shergill, Eun J Shin, Field Willingham, Jason A Dominitz
BACKGROUND AND AIMS: Since 1985, the American Society for Gastrointestinal Endoscopy (ASGE) has awarded grants for endoscopic-related research. The goals of this study were to examine trends in ASGE grant funding and to assess productivity of previous recipients of the ASGE grant awards. METHODS: This was a retrospective cohort analysis of all research grants awarded by the ASGE through 2009. Measures of academic productivity and self-assessment of the ASGE awards' impact on the recipients' careers were defined by using publicly available resources (eg, National Library of Medicine-PubMed) and administration of an electronic survey to award recipients...
September 2016: Gastrointestinal Endoscopy
Argyrios T Dellis, Vishal Shah, Elizabeth A Donley, Svenja Knappe, John Kitching
Laser spectroscopy of atoms confined in vapor cells can be strongly affected by the presence of background gases. A significant source of vacuum contamination is the permeation of gases such as helium (He) through the walls of the cell. Aluminosilicate glass (ASG) is a material with a helium permeation rate that is many orders of magnitude lower than borosilicate glass, which is commonly used for cell fabrication. We have identified a suitable source of ASG that is fabricated in wafer form and can be anodically bonded to silicon...
June 15, 2016: Optics Letters
Douglas S Fishman, Bruno P Chumpitazi, Isaac Raijman, Cynthia Man-Wai Tsai, E O'Brian Smith, Mark V Mazziotti, Mark A Gilger
AIM: To assess pediatric patients for choledocholithiasis. We applied current adult guidelines to identify predictive factors in children. METHODS: A single-center retrospective analysis was performed at a tertiary children's hospital. We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography (ERCP) for suspected choledocholithiasis. Patients were stratified into those with common bile duct stones (CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy (ASGE) guidelines (Very Strong and Strong criteria) for suspected CBDS...
June 10, 2016: World Journal of Gastrointestinal Endoscopy
Sri Komanduri, Nirav Thosani, Barham K Abu Dayyeh, Harry R Aslanian, Brintha K Enestvedt, Michael Manfredi, John T Maple, Udayakumar Navaneethan, Rahul Pannala, Mansour A Parsi, Zachary L Smith, Shelby A Sullivan, Subhas Banerjee
No abstract text is available yet for this article.
August 2016: Gastrointestinal Endoscopy
V Raman Muthusamy, Vinay Chandrasekhara, Ruben D Acosta, David H Bruining, Krishnavel V Chathadi, Mohamad A Eloubeidi, Ashley L Faulx, Lisa Fonkalsrud, Suryakanth R Gurudu, Mouen A Khashab, Shivangi Kothari, Jenifer R Lightdale, Shabana F Pasha, John R Saltzman, Aasma Shaukat, Amy Wang, Julie Yang, Brooks D Cash, John M DeWitt
No abstract text is available yet for this article.
July 2016: Gastrointestinal Endoscopy
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