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https://www.readbyqxmd.com/read/28987546/increase-in-female-faculty-in-asge-sponsored-programming-over-time
#1
Brintha K Enestvedt, Rebecca S DeVivo, Colleen M Schmitt, Audrey H Calderwood
BACKGROUND AND AIMS: Female representation in medicine is increasing across all levels of medical training yet women hold fewer senior leadership positions than men. National recognition, including participation as faculty in society-sponsored programs, is one component of academic advancement. The aim of this study was to characterize female representation among faculty in courses sponsored by the American Society for Gastrointestinal Endoscopy. (ASGE) METHODS: We performed a retrospective review of demographic data including faculty gender and role, year, and program type, from the ASGE database of its sponsored programs between 2009 and 2014...
October 4, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28984045/differentially-expressed-alternatively-spliced-genes-in-skeletal-muscle-from-cancer-patients-with-cachexia
#2
Ashok Narasimhan, Russell Greiner, Oliver F Bathe, Vickie Baracos, Sambasivarao Damaraju
BACKGROUND: Alternative splicing (AS) is a post-transcriptional gene regulatory mechanism that contributes to proteome diversity. Aberrant splicing mechanisms contribute to various cancers and muscle-related conditions such as Duchenne muscular dystrophy. However, dysregulation of AS in cancer cachexia (CC) remains unexplored. Our objectives were (i) to profile alternatively spliced genes (ASGs) on a genome-wide scale and (ii) to identify differentially expressed alternatively spliced genes (DASGs) associated with CC...
October 6, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28978541/comparison-of-midupper-arm-circumference-and-weight-for-height-z-score-for-assessing-acute-malnutrition-in-bangladeshi-children-aged-6-60-mo-an-analytical-study
#3
Md Iqbal Hossain, Tahmeed Ahmed, Shams El Arifeen, Sk Masum Billah, Asg Faruque, M Munirul Islam, Alan A Jackson
Background: In clinical settings, wasting in childhood has primarily been assessed with the use of a weight-for-height z score (WHZ), and in community settings, it has been assessed via the midupper arm circumference (MUAC) with a cutoff <115 mm for severe wasting and <115-125 mm for moderate wasting. Our recent experience indicates that many wasted children were not identified when these cutoffs for MUAC were used.Objective: We determined the cutoffs for MUAC to detect wasting in Bangladeshi children aged 6-60 mo...
October 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28938959/rheumatoid-arthritis-complicates-noninvasive-whole-blood-gene-expression-testing-for-coronary-artery-disease
#4
Ryan Jessee, Erica Peart, Phil Beineke, Steven Rosenberg, James A Wingrove, William E Kraus, Kim M Huffman
BACKGROUND: Our objective was to evaluate an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive coronary artery disease (CAD) in patients with rheumatoid arthritis (RA). METHODS: We evaluated 20 pairs of nondiabetic coronary patients with and without RA, selected by matching on age, sex, race, body mass index, tobacco use, and number of diseased coronary vessels. Peripheral blood gene expression levels of 23 CAD-associated genes were measured, and a previously validated CAD risk score including age, sex, and gene expression levels (Corus CAD) was computed...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28818507/optimizing-quality-of-endoscopy-in-inflammatory-bowel-disease-focus-on-surveillance-and-management-of-colorectal-dysplasia-using-interactive-image-and-video-based-teaching
#5
Tonya R Kaltenbach, Roy M Soetikno, Rebecca DeVivo, Loren A Laine, Alan Barkun, Kenneth R McQuaid
BACKGROUND & AIMS: Varying recommendations regarding the detection and management of dysplasia can lead to uncertainty and may have impeded the uptake of strategies that could improve surveillance in patients with inflammatory bowel disease (IBD). As such, an educational event was held to assist in disseminating the recently published Surveillance for Colorectal Endoscopic Neoplasia Detection and Management in Inflammatory Bowel Disease Patients: International Consensus Recommendations (SCENIC)...
August 14, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28791325/survey-study-on-the-practice-patterns-in-the-endoscopic-management-of-malignant-distal-biliary-obstruction
#6
Dennis Yang, Yaseen B Perbtani, Qi An, Mitali Agarwal, Michael Riverso, Joydeep Chakraborty, Tony S Brar, Donevan Westerveld, Han Zhang, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov
BACKGROUND AND STUDY AIM:  Endoscopic biliary drainage for malignant distal biliary obstruction (MDBO) is a common practice. Controversy persists with regard to its role in resectable MDBO, the optimal technical method and type of stent. The aim of this study was to evaluate practice patterns in the treatment of MDBO among endoscopists with varying levels of experience and practice backgrounds. METHODS:  Electronic survey distributed to members of the American Society for Gastrointestinal Endoscopy (ASGE)...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28731990/-performance-of-asge-predictive-criteria-in-diagnosis-of-choledocholithiasis-in-the-edgardo-rebagliati-martins-hospital
#7
Harold Eduardo Benites Goñi, Fernando Vicente Palacios Salas, Jairo Luis Asencios Cusihuallpa, Rossmery Aguilar Morocco, Nasthya Solange Segovia Valle
BACKGROUND: In Peru, there are still no local studies designed for evaluating the performance of clinical guidelines designed to stratify patients according to probability of choledocholithiasis. OBJECTIVES: To evaluate the performance of predictive criteria proposed by the American Society for Gastrointestinal Endoscopy (ASGE) in diagnosis of choledocholithiasis. MATERIALS AND METHODS: A retrospective cohort study conducted in a hospital in Lima (Rebagliati hospital)...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28715771/a-flow-through-aqueous-standard-generation-system-for-thin-film-microextraction-investigations-of-uv-filters-and-biocides-partitioning-to-different-environmental-compartments
#8
Fardin Ahmadi, Chris Sparham, Janusz Pawliszyn
In this paper problems associated with preparation of aqueous standard of highly hydrophobic compounds such as partial precipitation, being lost on the surfaces, low solubility in water and limited sample volume for accurate determination of their distribution coefficients are addressed. The following work presents two approaches that utilize blade thin film microextraction (TFME) to investigate partitioning of UV filters and biocides to humic acid (dissolved organic carbon) and sediment. A steady-state concentration of target analytes in water was generated using a flow-through aqueous standard generation (ASG) system...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28708521/flow-cytometric-enrichment-of-pacific-bluefin-tuna-type-a-spermatogonia-based-on-light-scattering-properties
#9
REVIEW
Kensuke Ichida, Kazuyoshi Kise, Tetsuro Morita, Ryosuke Yazawa, Yutaka Takeuchi, Goro Yoshizaki
We previously established surrogate broodstock in which the donor germ cells transplanted into the peritoneal cavities of xenogeneic recipients were capable of developing into functional eggs and sperm in teleost fish. In this transplantation system, only the undifferentiated germ cells such as type A spermatogonia (ASG) or a portion of the ASG population were capable of being incorporated into the genital ridges of the recipients and undergo gametogenesis. Therefore, the use of enriched ASGs can be expected to achieve efficient donor-cell incorporation...
June 22, 2017: Theriogenology
https://www.readbyqxmd.com/read/28677762/general-regulatory-effects-of-hypoxia-on-human-cartilage-endplate%C3%A2-derived-stem-cells-a-genome%C3%A2-wide-analysis-of-differential-gene-expression-and-alternative-splicing-events
#10
Yuan Yao, Weilin Song, Qiyue Deng, Huiyu Zhang, Jian Wang, Huan Liu, Yue Zhou
Intervertebral disc (IVD) degeneration of is considered to be initiated by the degeneration of the cartilage endplate (CEP). CEP‑derived stem cells (CESCs) with the capacity for osteochondrogenic differentiation may be responsible for CEP cartilage restoration. As CEP is avascular and hypoxic, and hypoxia can greatly influence biological activities of stem cells, physiological hypoxia may serve important roles in regulating the physiological functions of CESCs. The aim of the present study was to investigate the mechanisms of hypoxia‑regulated CESCs fate by using the Human Transcriptome Array 2...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28666916/emerging-roles-for-conjugated-sterols-in-plants
#11
REVIEW
Albert Ferrer, Teresa Altabella, Montserrat Arró, Albert Boronat
In plants, sterols are found in free form (free sterols, FSs) and conjugated as steryl esters (SEs), steryl glycosides (SGs) and acyl steryl glycosides (ASGs). Conjugated sterols are ubiquitously found in plants but their relative contents highly differ among species and their profile may change in response to developmental and environmental cues. SEs play a central role in membrane sterol homeostasis and also represent a storage pool of sterols in particular plant tissues. SGs and ASGs are main components of the plant plasma membrane (PM) that specifically accumulate in lipid rafts, PM microdomains known to mediate many relevant cellular processes...
July 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28656244/a-genome-wide-analysis-of-the-gene-expression-profiles-and-alternative-splicing-events-during-the-hypoxia-regulated-osteogenic-differentiation-of-human-cartilage-endplate-derived-stem-cells
#12
Yuan Yao, Qiyue Deng, Chao Sun, Weiling Song, Huan Liu, Yue Zhou
It has been hypothesized that intervertebral disc degeneration is initiated by degeneration of the cartilage endplate (CEP), which is characterized by cartilage ossification. CEP‑derived stem cells (CESCs), with the potential for chondro‑osteogenic differentiation, may be responsible for the balance between chondrification and ossification in the CEP. The CEP remains in an avascular and hypoxic microenvironment; the present study observed that hypoxia was able to markedly inhibit the osteogenic differentiation of CESCs...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28654261/astragalin-reduces-hexokinase-2-through-increasing-mir-125b-to-inhibit-the-proliferation-of-hepatocellular-carcinoma-cells-in-vitro-and-in-vivo
#13
Wei Li, Ji Hao, Lang Zhang, Zhuo Cheng, Xukun Deng, Guangwen Shu
Astragalin (ASG) can be found in a variety of food components. ASG exhibits cytotoxic effects on several different types of malignant cells. However, its effects on hepatocellular carcinoma (HCC) cells and the underlying molecular mechanisms have remained to be fully elucidated. Here, we revealed that ASG remarkably suppressed the proliferation of HCC cells. In HCC cells, ASG inhibited glucose glycolysis and promoted oxidative phosphorylation, resulting in a surge of reactive oxygen species (ROS). Mechanistically, ASG suppressed the expression of hexokinase 2 (HK2)...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28625816/a-prospective-multicenter-study-evaluating-learning-curves-and-competence-in-endoscopic-ultrasound-and-endoscopic-retrograde-cholangiopancreatography-among-advanced-endoscopy-trainees-the-rapid-assessment-of-trainee-endoscopy-skills-study
#14
Sachin Wani, Rajesh Keswani, Matt Hall, Samuel Han, Meer Akbar Ali, Brian Brauer, Linda Carlin, Amitabh Chak, Dan Collins, Gregory A Cote, David L Diehl, Christopher J DiMaio, Andrew Dries, Ihab El-Hajj, Swan Ellert, Kimberley Fairley, Ashley Faulx, Larissa Fujii-Lau, Srinivas Gaddam, Seng-Ian Gan, Jonathan P Gaspar, Chitiki Gautamy, Stuart Gordon, Cynthia Harris, Sarah Hyder, Ross Jones, Stephen Kim, Srinadh Komanduri, Ryan Law, Linda Lee, Rawad Mounzer, Daniel Mullady, V Raman Muthusamy, Mojtaba Olyaee, Patrick Pfau, Shreyas Saligram, Cyrus Piraka, Amit Rastogi, Laura Rosenkranz, Fadi Rzouq, Aditi Saxena, Raj J Shah, Violette C Simon, Aaron Small, Jayaprakash Sreenarasimhaiah, Andrew Walker, Andrew Y Wang, Rabindra R Watson, Robert H Wilson, Patrick Yachimski, Dennis Yang, Steven Edmundowicz, Dayna S Early
BACKGROUND & AIMS: On the basis of the Next Accreditation System, trainee assessment should occur on a continuous basis with individualized feedback. We aimed to validate endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) learning curves among advanced endoscopy trainees (AETs) by using a large national sample of training programs and to develop a centralized database that allows assessment of performance in relation to peers. METHODS: ASGE recognized training programs were invited to participate, and AETs were graded on ERCP and EUS exams by using a validated competency assessment tool that assesses technical and cognitive competence in a continuous fashion...
June 16, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28619398/global-burden-of-disease-of-mercury-used-in-artisanal-small-scale-gold-mining
#15
Nadine Steckling, Myriam Tobollik, Dietrich Plass, Claudia Hornberg, Bret Ericson, Richard Fuller, Stephan Bose-O'Reilly
BACKGROUND: Artisanal small-scale gold mining (ASGM) is the world's largest anthropogenic source of mercury emission. Gold miners are highly exposed to metallic mercury and suffer occupational mercury intoxication. The global disease burden as a result of this exposure is largely unknown because the informal character of ASGM restricts the availability of reliable data. OBJECTIVE: To estimate the prevalence of occupational mercury intoxication and the disability-adjusted life years (DALYs) attributable to chronic metallic mercury vapor intoxication (CMMVI) among ASGM gold miners globally and in selected countries...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28575233/stem-cell-activity-of-type-a-spermatogonia-is-seasonally-regulated-in-rainbow-trout
#16
Mana Sato, Makoto Hayashi, Goro Yoshizaki
Spermatogonial stem cells (SSCs) support continuous production of sperm throughout the male's life. However, the biological characteristics of SSCs are poorly understood in animals exhibiting seasonal reproduction, even though most wild animals are seasonal breeders. During the spermiation season in rainbow trout, the lumen of the testes contains only spermatozoa and scattered type A spermatogonia (ASG) along the walls of the testicular lobules. These few remaining ASG, designated "residual ASG," are the only germ cells capable of supporting the next spermatogenesis, suggesting that the residual ASG are true SSCs...
June 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28571127/physicochemical-characteristics-of-rat-muscle-glycogen-fractions
#17
Zahra Ghafouri, Mehdi Rasouli
INTRODUCTION: Homogenization of animal tissues with cold Perchloric Acid (PCA) produces two fractions of glycogen, Acid Soluble Glycogen (ASG) and Acid Insoluble Glycogen (AIG). AIM: To determine some physicochemical characteristics of muscle glycogen fractions in two groups of rat. MATERIALS AND METHODS: An experimental study was conducted on two groups of five male rats. Rats in control group were kept at rest and in case group on 30 minutes physical activity...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28556204/optimal-combination-of-anti-scatter-grids-and-software-correction-for-cbct-imaging
#18
Uros Stankovic, Lennert S Ploeger, Marcel van Herk, Jan-Jakob Sonke
PURPOSE: Cone beam computed tomography (CBCT) has been widely adopted in clinical practice for image-guided radiotherapy. Soft tissue contrast and Hounsfield units are impaired to the presence of scattered radiation. In our previous work, we proposed a high selectivity anti-scatter grid (ASG) as a possible solution to the problem. An alternative approach is the application of iterative scatter correction using deconvolution with scatter point spread function (PSF). The purpose of this work was to compare the performance of ASGs with different selectivity with and without the iterative and uniform scatter corrections in terms of CBCT image quality...
May 29, 2017: Medical Physics
https://www.readbyqxmd.com/read/28545665/astragaloside%C3%A2-against-cardiac-fibrosis-by-inhibiting-trpm7-channel
#19
Jun Lu, Quan-Yi Wang, Yang Zhou, Xiao-Chun Lu, Yong-Hui Liu, Yan Wu, Qiao Guo, Yun-Tian Ma, Yi-Qun Tang
BACKGROUND: Astragaloside Ⅳ (ASG-Ⅳ, (Fig. 1) is the most active component of Chinese sp. Astragalus membranaceus Bunge (Fabaceae) that has showed antioxidant, antiapoptotic and antiviral activities among others. It is reported to play an important role in cardiac fibrosis (CF), but the mechanism remains unclear. PURPOSE: To investigate the mechanism of ASG-Ⅳ on inhibiting myocardial fibrosis induced by hypoxia. STUDY DESIGN: We studied the relationship between anti-fibrotic effect of ASG-Ⅳ and transient receptor potential cation channel, subfamily M, member 7 (TRPM7) by in vivo and in vitro experiments...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28535766/a-novel-anatomic-severity-grading-score-for-acute-type-b-aortic-dissections-and-correlation-to-aortic-reinterventions-after-thoracic-endovascular-aortic-repair
#20
Shirui Chen, Sebastian Larion, Sadaf S Ahanchi, Chad P Ammar, Colin T Brandt, Jean M Panneton
BACKGROUND: We introduce a novel preoperative anatomic severity grading system for acute type B aortic dissections and validate the system in a cohort of patients who underwent thoracic endovascular aortic repair. METHODS: We identified a cohort of patients who received thoracic endovascular aortic repair (TEVAR) for acute type B aortic dissection from 2008 to 2014. We developed an anatomic severity grading score (ASG) to measure attributes of aortic anatomy that we hypothesized may affect difficulty or durability of repair...
May 23, 2017: Journal of Cardiothoracic Surgery
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