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https://www.readbyqxmd.com/read/28103621/development-and-validation-of-a-training-module-on-the-use-of-acetic-acid-for-the-detection-of-barrett-s-neoplasia
#1
Fergus J Q Chedgy, Kesavan Kandiah, Hugh Barr, Simon Dwerryhouse, Balint Eross, Charles Gordon, Susi Green, Andy Li, James Brown, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Acetic acid chromoendoscopy (AAC) enhances the ability to correctly identify Barrett's neoplasia, and is increasingly used by both expert and nonexpert endoscopists. Despite its increasing use, there is no validated training strategy to achieve competence. The aims of our study were to develop a validated training tool in AAC-assisted lesion recognition, to assess endoscopists' baseline knowledge of AAC-assisted lesion recognition, and to evaluate the efficacy and impact of this training tool...
January 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28098904/identification-of-biomarkers-of-intrahepatic-cholangiocarcinoma-via-integrated-analysis-of-mrna-and-mirna-microarray-data
#2
Yaqing Chen, Dan Liu, Pengfei Liu, Yajing Chen, Huiling Yu, Quan Zhang
The present study aimed to identify potential therapeutic targets of intrahepatic cholangiocarcinoma (ICC) via integrated analysis of gene (transcript version) and microRNA (miRNA/miR) expression. The miRNA microarray dataset GSE32957 contained miRNA expression data from 16 ICC, 7 mixed type of combined hepatocellular‑cholangiocarcinoma (CHC), 2 hepatic adenoma, 3 focal nodular hyperplasia (FNH) and 5 healthy liver tissue samples, and 2 cholangiocarcinoma cell lines. In addition, the mRNA microarray dataset GSE32879 contained mRNA expression data from 16 ICC, 7 CHC, 2 hepatic adenoma, 5 FNH and 7 healthy liver tissue samples...
January 16, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28089029/guidelines-for-privileging-credentialing-and-proctoring-to-perform-gi-endoscopy
#3
Ashley L Faulx, Jenifer R Lightdale, Ruben D Acosta, Deepak Agrawal, David H Bruining, Vinay Chandrasekhara, Mohamad A Eloubeidi, Robert D Fanelli, Suryakanth R Gurudu, Loralee Kelsey, Mouen A Khashab, Shivangi Kothari, V Raman Muthusamy, Bashar J Qumseya, Aasma Shaukat, Amy Wang, Sachin B Wani, Julie Yang, John M DeWitt
No abstract text is available yet for this article.
February 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28071059/accuracy-of-asge-criteria-for-the-prediction-of-choledocholithiasis
#4
Jacobo Dib
I read with interest the article "Accuracy of ASGE criteria for the prediction of choledocholithiasis" by Nárvaez et al. Patients with suspicion of choledocholithiasis (CL) were categorized according to the American Society for Gastrointestinal Endoscopy (ASGE) recommendations. Those patients classified into high or intermediate-probability for CL underwent an endoscopic retrograde cholangiopancreatography (ERCP) without any further non-endoscopic biliary imaging modalities. In the ASGE recommendations for intermediate risk CL patients, they mention options for the evaluation of these patients including endoscopic ultrasound (EUS) and magnetic resonance cholangiography (MRC)...
January 10, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28065885/endoscopic-retrograde-cholangiopancreatography-with-ampullary-biopsy-vs-ercp-alone-a-matched-pairs-controlled-evaluation-of-outcomes-and-complications
#5
Sunil Dacha, Saurabh Chawla, Jai Eun Lee, Steven A Keilin, Qiang Cai, Field F Willingham
BACKGROUND AND AIMS: Biopsy of the ampulla of Vater may be performed to evaluate for ampullary adenomas, suspected ampullary tumors and immunohistological staining for autoimmune pancreatitis. Ampullary biopsies are commonly performed at the time of endoscopic retrograde cholangiopancreatography (ERCP). Due to the well-established complication rate following ERCP, the contribution of ampullary biopsy as a potential independent risk factor would require a controlled comparison. METHODS: A matched-pairs, case-control analysis was performed for patients undergoing ERCP with or without ampullary biopsy...
January 8, 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28051264/homogenization-versus-homogenization-free-method-to-measure-muscle-glycogen-fractions
#6
N Mojibi, M Rasouli
OBJECTIVE: The glycogen is extracted from animal tissues with or without homogenization using cold perchloric acid. Three methods were compared for determination of glycogen in rat muscle at different physiological states. MATERIALS AND METHODS: Two groups of five rats were kept at rest or 45 minutes muscular activity. The glycogen fractions were extracted and measured by using three methods. RESULTS: The data of homogenization method shows that total glycogen decreased following 45 min physical activity and the change occurred entirely in acid soluble glycogen (ASG), while AIG did not change significantly...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28046458/we-ab-207a-10-transmission-characteristics-of-a-two-dimensional-antiscatter-grid-prototype-for-cbct
#7
C Altunbas, B Kavanagh, M Miften
PURPOSE: Scattered radiation remains to be a major contributor to image quality degradation in CBCT. To address the scatter problem, a focused, 2D antiscatter grid (2DASG) prototype was designed, and fabricated using additive manufacturing processes. Its scatter and primary transmission properties were characterized using a linac mounted CBCT system. METHODS: The prototype 2DASG was composed of rectangular grid holes separated by tungsten septa, and has a grid pitch of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025817/cost-effectiveness-of-metal-stents-in-relieving-obstructive-jaundice-in-patients-with-pancreatic-cancer
#8
J M Martinez, A Anene, T G K Bentley, M J Cangelosi, L M Meckley, J D Ortendahl, A J Montero
BACKGROUND: ASGE and ESGE guidelines recommend endoscopic metal stent placement for pancreatic carcinoma patients with biliary obstruction, and whose estimated life expectancy is greater than 6 months. Because median overall survival (OS) of metastatic pancreatic adenocarcinoma until recently has been less than 6 months, plastic biliary stents were preferentially placed rather than metal due to the greater upfront cost of the latter. Recent advances in the treatment of metastatic pancreatic cancer have extended median OS beyond the 6-month range...
December 27, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27995197/eus-guided-biliary-drainage-or-enteroscopy-assisted-ercp-in-patients-with-surgical-anatomy-and-biliary-obstruction-an-international-comparative-study
#9
Mouen A Khashab, Mohamad H El Zein, Kaveh Sharzehi, Fernando P Marson, Oleh Haluszka, Aaron J Small, Yousuke Nakai, Do Hyun Park, Rastislav Kunda, Anthony Y Teoh, Irene Peñas, Manuel Perez-Miranda, Vivek Kumbhari, Schalk Van der Merwe, Everson L Artifon, Andrew S Ross
Background and study aims: How enteroscopy-assisted ERCP (e-ERCP) and endoscopic ultrasound-guided biliary drainage (EUS-BD) compare in patients with surgically altered upper gastrointestinal anatomy is currently unknown. The aims of this study were to compare efficacy and safety of both techniques and study predictors of these outcomes. Patients and methods: This was an international, multicenter comparative cohort study at 10 tertiary centers. Outcomes data included technical success (biliary access with cholangiography and stent placement [when indicated]), clinical success (resolution of biliary obstruction) and adverse events (AEs) (graded according to the ASGE lexicon)...
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27993573/clinical-utility-of-a-precision-medicine-test-evaluating-outpatients-with-suspected-obstructive-coronary-artery-disease
#10
Joseph A Ladapo, Matt Budoff, David Sharp, Michael Zapien, Lin Huang, Bruce Maniet, Lee Herman, Mark Monane
BACKGROUND: Identifying patients with obstructive coronary artery disease can be challenging for primary care physicians. Advances in precision medicine may help augment clinical tools and redefine the paradigm for evaluating coronary artery disease in the outpatient setting. A blood-based age/sex/gene expression score (ASGES) incorporating key features of precision medicine has shown clinical validity with a 96% negative predictive value and 89% sensitivity in estimating a symptomatic patient's current likelihood of obstructive coronary artery disease...
December 16, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27984170/autism-genes-are-selectively-targeted-by-environmental-pollutants-including-pesticides-heavy-metals-bisphenol-a-phthalates-and-many-others-in-food-cosmetics-or-household-products
#11
REVIEW
C J Carter, R A Blizard
The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database. Any bias towards ASG's was statistically determined for each chemical. Many suspect compounds identified in epidemiology, including tetrachlorodibenzodioxin, pesticides, particulate matter, benzo(a)pyrene, heavy metals, valproate, acetaminophen, SSRI's, cocaine, bisphenol A, phthalates, polyhalogenated biphenyls, flame retardants, diesel constituents, terbutaline and oxytocin, inter alia showed a significant degree of bias towards ASG's, as did relevant endogenous agents (retinoids, sex steroids, thyroxine, melatonin, folate, dopamine, serotonin)...
October 27, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27981542/extraction-of-glycogen-on-mild-condition-lacks-aig-fraction
#12
Z Ghafouri, M Rasouli
OBJECTIVE: Extraction of animal tissues with cold water or perchloric acid yields less glycogen than is obtained with hot-alkaline. Extraction with acid and alkaline gives two fractions, acid soluble (ASG) and insoluble glycogen (AIG). The aim of this work is to examine the hypothesis that not all liver glycogen is extractable by Tris-buffer using current techniques. MATERIALS AND METHODS: Rat liver was homogenized with Tris-buffer pH 8.3 and extracted for the glycogen fractions, ASG and AIG...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27942238/targeted-transplantation-of-mitochondria-to-hepatocytes
#13
Nidhi Gupta, Catherine H Wu, George Y Wu
BACKGROUND: Mitochondrial defects in hepatocytes can result in liver dysfunction and death. Hepatocytes have cell-surface asialoglycoprotein receptors (AsGRs) which internalize AsGs within endosomes. The aim of this study was to determine whether mitochondria could be targeted to hepatocytes by AsGR-mediated endocytosis. MATERIALS AND METHODS: An AsG, AsOR, was linked to polylysine to create a conjugate, AsOR-PL, and complexed with healthy and functional mitochondria (defined by normal morphology, cytochrome c assays, and oxygen-consumption rates)...
2016: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/27924368/a-quantitative-readability-analysis-of-patient-education-resources-from-gastroenterology-society-websites
#14
David R Hansberry, Sahil R Patel, Prateek Agarwal, Nitin Agarwal, Elizabeth S John, Ann M John, James C Reynolds
BACKGROUND AND AIMS: The lay public frequently access and rely on online information as a source of their medical knowledge. Many medical societies are unaware of national patient education material guidelines and subsequently fail to meet them. The goal of the present study was to evaluate the readability of patient education materials within the medical field of gastroenterology. METHODS: Two hundred fourteen articles pertaining to patient education materials were evaluated with ten well-established readability scales...
December 6, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27914763/management-of-suspected-common-bile-duct-stone-diagnostic-yield-of-current-guideline
#15
Ufuk B Kuzu, Bülent Ödemiş, Selçuk Dişibeyaz, Erkan Parlak, Erkin Öztaş, Fatih Saygılı, Hakan Yıldız, Mustafa Kaplan, Orhan Coskun, Adem Aksoy, Derya Arı, Nuretdin Suna, Ertuğrul Kayaçetin
BACKGROUND: The American Society for Gastrointestinal Endoscopy (ASGE) has recently published a guideline for suspected CBDS with the intention of reducing unnecessary ERCP and thereby complications. The aim of this study was to assess the diagnostic efficacy of the ASGE guideline. METHODS: Data of patients who underwent ERCP with suspected CBDS were analyzed retrospectively. Patients were classified into high, intermediate and low risk groups based on predictors that have been suggested by the ASGE...
November 30, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27876513/are-high-lags-of-accommodation-in-myopic-children-due-to-motor-deficits
#16
Vivek Labhishetty, William R Bobier
Children with a progressing myopia exhibit an abnormal pattern of high accommodative lags coupled with high accommodative convergence (AC/A) and high accommodative adaptation. This is not predicted by the current models of accommodation and vergence. Reduced accommodative plant gain and reduced sensitivity to blur have been suggested as potential causes for this abnormal behavior. These etiologies were tested by altering parameters (sensory, controller and plant gains) in the Simulink model of accommodation...
January 2017: Vision Research
https://www.readbyqxmd.com/read/27834024/eus-guided-gastroenterostomy-is-comparable-to-enteral-stenting-with-fewer-re-interventions-in-malignant-gastric-outlet-obstruction
#17
Yen-I Chen, Takao Itoi, Todd H Baron, Jose Nieto, Yamile Haito-Chavez, Ian S Grimm, Amr Ismail, Saowanee Ngamruenphong, Majidah Bukhari, Gulara Hajiyeva, Ahmad S Alawad, Vivek Kumbhari, Mouen A Khashab
BACKGROUND AND AIMS: Endoscopic enteral stenting (ES) in malignant gastric outlet obstruction (GOO) is limited by high rates of stent obstruction. EUS-guided gastroenterostomy (EUS-GE) is a novel procedure that potentially offers sustained patency without tumor ingrowth/overgrowth. The aim of this study is to compare EUS-GE with ES in terms of (1) symptom recurrence and need for re-intervention, (2) technical success (proper stent positioning as determined via endoscopy and fluoroscopy), (3) clinical success (ability to tolerate oral intake without vomiting), and (4) procedure-related adverse events (AEs)...
November 10, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27831639/improvement-of-the-classical-assay-method-for-liver-glycogen-fractions-asg-is-the-main-and-metabolic-active-fraction
#18
H Shokri-Afra, A Ostovar-Ravari, M Rasouli
OBJECTIVE: Acid digestion of animal tissues yields two fractions of glycogen, acid soluble (ASG) and insoluble (AIG). The current study was performed to improve the assay method for glycogen fractions in rat liver in different physiological states. MATERIALS AND METHODS: All steps of the assay were manipulated and optimized to measure the content of ASG and AIG in fed and starved rat liver. RESULTS: In postmortem liver tissue, total glycogen was decreased slowly at 4°C and rapidly at 25°C but was well stabilized at -20°C and -70°C...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27765382/automated-endoscope-reprocessors
#19
Mansour A Parsi, Shelby A Sullivan, Adam Goodman, Michael Manfredi, Udayakumar Navaneethan, Rahul Pannala, Zachary L Smith, Nirav Thosani, Subhas Banerjee, John T Maple
No abstract text is available yet for this article.
October 17, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27676326/tetramethylpyrazine-and-astragaloside-iv-synergistically-ameliorate-left-ventricular-remodeling-and-preserve-cardiac-function-in-a-rat-myocardial-infarction-model
#20
Chuying Wang, Yumei Li, Xinxin Yang, Shengnan Bi, Yajie Zhang, Dong Han, Dafang Zhang
Tetramethylpyrazine (TMP) and astragaloside IV (AGS-IV) are herbal ingredients that have been demonstrated in animal models to limit infarct size and protect cardiomyocytes in the acute phase of myocardial infarction (MI), yet their long-term cardioprotective effects have not been evaluated. In this study, TMP and/or AGS-IV were administrated to rats for 14 days after MI. Echocardiography revealed that the left ventricular (LV) dimensions and cardiac function were preserved in the MI rats with TMP and AGS-IV treatment, compared with untreated MI rats...
January 2017: Journal of Cardiovascular Pharmacology
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