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Diastolic function, cardiac CT.

A V Sahasrabuddhe, S U Pitale, Dhoble, J Shivalkar, M M Sagdeo
BACKGROUND: To evaluate presence of diastolic dysfunction in obese peripubertal males (8-18 years of age). To correlate diastolic dysfunction with insulin resistance, insulin levels and omental and epicardial fat. METHODS: Obese males (n=46) and age matched healthy lean controls (n=50) in the age group of 8-18 years were included in this study. Anthropometric measurements were recorded. Investigations done: Fasting blood sugar and serum insulin levels, lipid profile, 2-D Echocardiography to assess left ventricular diastolic function and epicardial fat, abdominal CT scan to measure omental fat and ultrasound for NAFLD...
February 2016: Journal of the Association of Physicians of India
Angelo Squeri, Stefano Censi, Claudio Reverberi, Nicola Gaibazzi, Marco Baldelli, Simone Maurizio Binno, Enrico Properzi, Stefano Bosi
BACKGROUND: Accurate quantification of left ventricular (LV) volumes [end-diastolic volume (EDV) and end-systolic volume (ESV)] and ejection fraction (EF) is of critical importance. The development of real-time three-dimensional echocardiography (RT3DE) has shown better correlation than two-dimensional (2D) echocardiography with magnetic resonance imaging (MRI) measurements. The aim of our study was to assess the accuracy of RT3DE and 64-slice computed tomography (CT) in the evaluation of LV volumes and function using MRI as the reference standard in a real-world population with various types of heart disease with different chamber geometry...
September 2, 2016: Journal of Echocardiography
Peng Cao, Miao He, Chen Qiao, Nan Xu, Daoyi Huang, Gonghua Dai, Yibin Wang, Haihong Pan, Lei Zhang
OBJECTIVES: The aim of this study was to investigate the relationship between various patient-related factors (physical and cardiac hemodynamic parameters) and the coronary artery density on coronary CT angiography (CCTA). METHODS: A total of 64 patients (female: male ratio, 24:40; age, 58.2 years±9.3, age range, 31-81 years; mean body weight, 65.3 kg±11.6, range 40-88 kg) were effectively enrolled in this approved retrospective study. Patient-related physical factors including height, body weight (BW), body mass index (BMI), systolic blood pressure (BPsys), diastolic blood pressure (BPdis) and blood pulse pressure (Bp) were recorded, measured and calculated prior to the administration of contrast media during the CCTA...
September 2016: International Journal of Clinical Practice
Catherine Gebhard, Ronny R Buechel, Barbara E Stähli, Heidi Gransar, Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Benjamin Chow, Allison Dunning, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Ronen Rubinshtein, Hugo Marques, Augustin DeLago, Todd C Villines, Martin Hadamitzky, Joerg Hausleiter, Leslee J Shaw, Ricardo C Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, Jonathon Leipsic, James K Min, Philipp A Kaufmann
BACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53...
July 26, 2016: European Heart Journal Cardiovascular Imaging
Michinobu Nagao, Yuzo Yamasaki, Takeshi Kamitani, Satoshi Kawanami, Koji Sagiyama, Torahiko Yamanouchi, Yamato Shimomiya, Tetsuya Matoba, Yasushi Mukai, Keita Odashiro, Shingo Baba, Yasuhiro Maruoka, Yoshiyuki Kitamura, Akihiro Nishie, Hiroshi Honda
OBJECTIVES: Anatomical coronary stenosis is not always indicative of functional stenosis, particularly for intermediate coronary lesions. The purpose of this study is to propose a new method for quantifying coronary flow using dynamic CT angiography for the whole heart (heart-DCT) and investigate its ability for detecting ischemia from intermediate coronary stenosis. METHODS: Participants comprised 36 patients with coronary artery disease who underwent heart-DCT using 320-detector CT with tube voltage of 80kV and myocardial perfusion scintigraphy (MPS)...
May 2016: European Journal of Radiology
Bedia Kara, Alaaddin Nayman, Ibrahim Guler, Enes Elvin Gul, Mustafa Koplay, Yahya Paksoy
BACKGROUND: The purpose of this study was to compare the left ventricular parameters obtained from multi-detector row computed tomography (MDCT) studies with two-dimensional echocardiography (2DE), and magnetic resonance imaging (MRI), which is accepted as the gold standard in the evaluation of left ventricular functions. The study also aimed to evaluate whether or not there is a relationship between the MR-Argus and CMR tools software programs which are used in post-process calculations of data obtained by MRI...
2016: Polish Journal of Radiology
Gustavo Santos Masson, Juliana Pereira Borges, Pedro Paulo Soares da Silva, Antônio Cláudio Lucas da Nóbrega, Eduardo Tibiriçá, Marcos Adriano Lessa
INTRODUCTION: The ability of continuous aerobic exercise training (AET) to increase baroreflex control and cardiac function in heart failure (HF) has been well described, but the comparison between continuous and interval AET on these functions is inconclusive. OBJECTIVES: To compare the effects of continuous and interval AET on cardiac function and baroreflex sensitivity (BrS) in an experimental model of HF. METHODS: Rats were divided into the following groups: continuous training (HF-CT), intense interval training (HF-IIT), moderate interval training (HF-MIT), sedentary group (HF-SED), and sham sedentary (SHAM-SED)...
May 2016: Autonomic Neuroscience: Basic & Clinical
Luciene Ferreira Azevedo, Patricia Perlingeiro, Denise Tessariol Hachul, Igor Lucas Gomes-Santos, Jeane Mike Tsutsui, Carlos Eduardo Negrao, Luciana D N J De Matos
Different season trainings may influence autonomic and non-autonomic cardiac control of heart rate and provokes specific adaptations on heart's structure in athletes. We investigated the influence of transition training (TT) and competitive training (CT) on resting heart rate, its mechanisms of control, spontaneous baroreflex sensitivity (BRS) and relationships between heart rate mechanisms and cardiac structure in professional cyclists (N = 10). Heart rate (ECG) and arterial blood pressure (Pulse Tonometry) were recorded continuously...
2016: PloS One
Zhi-nan Lu, Sun Xing-guo, Song-shou Mao, M J Budoff, W W Stringer, Wan-gang Ge, Hao Li, Jie Huang, Fang Liu, Sheng-shou Hu
OBJECTIVE: For heart functional parameters, we commonly used normal range. The reference values and predict formulas of heart functional parameters and their relationships with individual characteristics are still lack. METHODS: Left ventricular (LV) volumes (end-diastolic volume and end-systolic volume), stroke volume (SV), ejection fraction (EF) and cardiac output (CO) were measured by cardiac CT angiography (CAT) in 1 200 healthy Caucasian volunteers, men 807 and women 393, and age 20-90yr...
July 2015: Chinese Journal of Applied Physiology
Richard A P Takx, Rozemarijn Vliegenthart, U Joseph Schoepf, Joseph A Abro, John W Nance, Ullrich Ebersberger, Fabian Bamberg, Christine M Carr, Paul Apfaltrer
Blacks have higher mortality and hospitalization rates because of congestive heart failure compared with white counterparts. Differences in cardiac structure and function may contribute to the racial disparity in cardiovascular outcomes. Our aim was to compare computed tomography (CT)-derived cardiac measurements between black patients with acute chest pain and age- and gender-matched white patients. We performed a retrospective analysis under an institutional review board waiver and in Health Insurance Portability and Accountability Act compliance...
February 1, 2016: American Journal of Cardiology
Anna Axelsson, Kasper Iversen, Niels Vejlstrup, Carolyn Y Ho, Ole Havndrup, Klaus F Kofoed, Jakob Norsk, Morten Jensen, Henning Bundgaard
OBJECTIVE: There is a lack of disease-modifying treatments in hypertrophic cardiomyopathy (HCM). The aim of this randomised, placebo-controlled study was to assess if losartan could improve or ameliorate deterioration of cardiac function and exercise capacity. METHODS: Echocardiography, exercise test and MRI or CT were performed at baseline and after 12 months in 133 patients (52±13 years, 35% female) randomly allocated to losartan (100 mg/day) or placebo...
February 15, 2016: Heart: Official Journal of the British Cardiac Society
Sonya V Babu-Narayan, George Giannakoulas, Anne Marie Valente, Wei Li, Michael A Gatzoulis
Imaging is fundamental to the lifelong care of adult congenital heart disease (ACHD) patients. Echocardiography remains the first line imaging for inpatient, outpatient, or perioperative care. Cross-sectional imaging with cardiovascular magnetic resonance (CMR) or computed tomography (CT) provides complementary and invaluable information on cardiac and vascular anatomy and other intra-thoracic structures. Furthermore, CMR provides quantification of cardiac function and vascular flow. Cardiac catheterization is mostly reserved for assessment of pulmonary vascular resistance, ventricular end-diastolic pressure, and percutaneous interventions...
April 14, 2016: European Heart Journal
Jianfeng Wang, Yuetao Wang, Xiaoli Zhang, Ruijue Zhou, Rong Niu, Peiqi Lu
OBJECTIVE: To assess the left ventricular (LV) systolic synchrony by phase analysis of gated myocardial perfusion imaging (GMPI) with SPECT/CT in patients with old myocardial infarction (OMI) and further to identify independent predictors for LV dyssynchrony. METHODS: Seventy-six OMI patients and seventy-four healthy volunteers (control group) underwent resting GMPI from October 2010 to September 2013 in our hospital were included in this study. The left ventricular systolic synchrony parameters including phase histogram bandwidth (BW) and phase standard deviation (SD) were obtained by Cedars-Sinai quantitative gated SPECT (QGS) phase analysis technique, and LV cardiac function was also measured...
July 2015: Zhonghua Xin Xue Guan Bing za Zhi
Fatma E Akin, Cenk Sari, Sevil Özer-Sari, Aylin Demirezer-Bolat, Tahir Durmaz, Telat Keles, Osman Ersoy, Engin Bozkurt
BACKGROUND/AIM: The aim of this study was to investigate the effects of celiac disease on cardiac functions using tissue Doppler echocardiography (TDE). PATIENTS AND METHODS: The study included 30 patients with celiac disease (CD) and 30 healthy volunteers. Echocardiographic examinations were assessed by conventional echocardiography and tissue Doppler imaging. The peak systolic velocity (S ' m), early diastolic myocardial peak velocity (E ' m), late diastolic myocardial peak velocity (A ' m), E ' m/A ' m ratio, myocardial precontraction time (PCT ' m), myocardial contraction time (CT ' m), and myocardial isovolumetric relaxation time (IVRT ' m), E to E ' m ratio were measured...
September 8, 2015: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Young Joo Suh, Byung-Chul Chang, Dong Jin Im, Yun Jung Kim, Yoo Jin Hong, Geu-Ru Hong, Young Jin Kim
OBJECTIVES: This study investigated computed tomographic (CT) appearance after mitral ring annuloplasty, especially comparing CT findings between patients with normal pressure gradient (PG) and patients with functional mitral stenosis (MS) and between 2 commonly used types of annuloplasty ring. METHODS: A total of 45 cardiac CT scans in patients who underwent mitral ring annuloplasty (Carpentier-Edwards ring, n = 27; Duran ring, n = 18) were retrospectively reviewed...
November 2015: Journal of Thoracic and Cardiovascular Surgery
Dimitrios Maragiannis, Robert C Schutt, Nickalaus L Gramze, Kongkiat Chaikriangkrai, Kelly McGregor, Karen Chin, Faisal Nabi, Stephen H Little, Sherif F Nagueh, Su Min Chang
AIM: Diastolic dysfunction is a common problem in patients with obesity, hypertension, diabetes, or coronary artery disease. The purpose of this study was to evaluate the association of left ventricular diastolic dysfunction with an abnormal coronary artery calcium score (CAC score). METHODS: This study considered a cohort of patients ≥ 18 years of age with normal ejection fraction who were admitted to the hospital with chest pain. All patients underwent regadenoson myocardial perfusion stress imaging and had no evidence of ischemia or infarction...
2015: Journal of Atherosclerosis and Thrombosis
Luis Gamella-Pozuelo, Isabel Fuentes-Calvo, Manuel A Gómez-Marcos, José I Recio-Rodriguez, Cristina Agudo-Conde, José L Fernández-Martín, Jorge B Cannata-Andía, José M López-Novoa, Luis García-Ortiz, Carlos Martínez-Salgado
The search for biomarkers of hypertension and diabetes-induced damage to multiple target organs is a priority. We analyzed the correlation between plasma cardiotrophin-1 (CT-1), a chemokine that participates in cardiovascular remodeling and organ fibrosis, and a wide range of parameters currently used to diagnose morphological and functional progressive injury in left ventricle, arteries, and kidneys of diabetic and hypertensive patients, in order to validate plasma levels of CT-1 as clinical biomarker.This is an observational study with 93 type 2-diabetic patients, 209 hypertensive patients, and 82 healthy controls in which we assessed the following parameters: plasma CT-1, basal glycaemia, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), left ventricular hypertrophy (LVH by electrocardiographic indexes), peripheral vascular disease (by pulse wave velocity-PWV, carotid intima-media thickness-C-IMT, and ankle-brachial index-ABI), and renal impairment (by microalbuminuria, albumin/creatinine urinary ratio, plasma creatinine concentrations, and glomerular filtration rate)...
July 2015: Medicine (Baltimore)
Ariel Schweitzer, Yoram Agmon, Doron Aronson, Sobhi Abadi, Diab Mutlak, Shemy Carasso, Jonathan R Walker, Jonathan Lessick
BACKGROUND: Left ventricular (LV) diastolic dysfunction (DD) often accompanies coronary artery disease but is difficult to assess since it involves a complex interaction between LV filling and left atrial (LA) emptying. OBJECTIVE: To characterize simultaneous changes in LA and LV volumes using cardiac computed tomography (CT) in a group of patients with various grades of DD based on echocardiography. METHODS: We identified 35 patients with DD by echocardiography, who had also undergone cardiac CT, and 35 age-matched normal controls...
October 2015: European Journal of Radiology
Andrew J Wawrzyniak, Vasken Dilsizian, David S Krantz, Kristie M Harris, Mark F Smith, Anthony Shankovich, Kerry S Whittaker, Gabriel A Rodriguez, John Gottdiener, Shuying Li, Willem Kop, Stephen S Gottlieb
UNLABELLED: Mental stress can trigger myocardial ischemia, but the prevalence of mental stress-induced ischemia in congestive heart failure (CHF) patients is unknown. We characterized mental stress-induced and adenosine-induced changes in myocardial perfusion and neurohormonal activation in CHF patients with reduced left-ventricular function using SPECT to precisely quantify segment-level myocardial perfusion. METHODS: Thirty-four coronary artery disease patients (mean age±SD, 62±10 y) with CHF longer than 3 mo and ejection fraction less than 40% underwent both adenosine and mental stress myocardial perfusion SPECT on consecutive days...
October 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Lian R Gao, Yu Chen, Ning K Zhang, Xi L Yang, Hui L Liu, Zhi G Wang, Xiao Y Yan, Yu Wang, Zhi M Zhu, Tian C Li, Li H Wang, Hai Y Chen, Yun D Chen, Chao L Huang, Peng Qu, Chen Yao, Bin Wang, Guang H Chen, Zhong M Wang, Zhao Y Xu, Jing Bai, Di Lu, Yan H Shen, Feng Guo, Mu Y Liu, Yong Yang, Yan C Ding, Ye Yang, Hai T Tian, Qing A Ding, Li N Li, Xin C Yang, Xiang Hu
BACKGROUND: The use of adult stem cells is limited by the quality and quantity of host stem cells. It has been demonstrated that Wharton's jelly-derived mesenchymal stem cells (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues and significantly improve heart function. In this randomized, controlled trial, our aim was to assess the safety and efficacy of intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI). METHODS: In a multicenter trial, 116 patients with acute ST-elevation MI were randomly assigned to receive an intracoronary infusion of WJMSCs or placebo into the infarct artery at five to seven days after successful reperfusion therapy...
2015: BMC Medicine
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