keyword
MENU ▼
Read by QxMD icon Read
search

carcinoma hepatocellular

keyword
https://www.readbyqxmd.com/read/29166754/advances-in-oncological-treatment-limitations-of-recist-1-1-criteria
#1
Serena Grimaldi, Marie Terroir, Caroline Caramella
INTRODUCTION: RECIST 1.1 criteria are the standard for the response assessment of most solid tumors on computed tomography (CT). Nevertheless, the emergence of new classes of treatment in the lasts decades has brought new challenges in the response evaluation. EVIDENCE ACQUISITION: A PubMed online database literature search was performed in order to identify papers in English with full text available published up to September 2017. EVIDENCE SYNTHESIS: Some oncologic treatments, such as anti-angiogenic agents, immunotherapy and local treatments, have proven to be effective despite atypical patterns of responses...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166610/cisd2-haploinsufficiency-disrupts-calcium-homeostasis-causes-nonalcoholic-fatty-liver-disease-and-promotes-hepatocellular-carcinoma
#2
Zhao-Qing Shen, Yi-Fan Chen, Jim-Ray Chen, Yuh-Shan Jou, Pei-Chun Wu, Cheng-Heng Kao, Chih-Hao Wang, Yi-Long Huang, Chian-Feng Chen, Ting-Shuo Huang, Yu-Chiau Shyu, Shih-Feng Tsai, Lung-Sen Kao, Ting-Fen Tsai
CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cisd2 haploinsufficiency causes a low incidence (20%) of spontaneous HCC and promotes HBV-associated and DEN-induced HCC; conversely, 2-fold overexpression of Cisd2 suppresses HCC in these models. Mechanistically, Cisd2 interacts with Serca2b and mediates its Ca(2+) pump activity via modulation of Serca2b oxidative modification, which regulates ER Ca(2+) uptake and maintains intracellular Ca(2+) homeostasis in the hepatocyte...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166570/splenectomy-after-partial-hepatectomy-accelerates-liver-regeneration-in-mice-by-promoting-tight-junction-formation-via-polarity-protein-par-3-apkc
#3
Guoxing Liu, Chengzhi Xie, Yu Fang, Ke Qian, Qiang Liu, Gao Liu, Zhenyu Cao, Huihui Du, Jie Fu, Xundi Xu
AIMS: Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MAIN METHODS: We analyzed the cytokines, genes and proteins expression between 70% partial hepatectomy mice (PHx) and simultaneous 70% partial hepatectomy and splenectomy mice (PHs) at predetermined timed points...
November 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/29166330/hepatic-falciform-artery-demonstrating-maa-uptake-in-the-anterior-abdomen-prior-to-embolization
#4
Dhruv Patel, Ken Le, Joga Chaganti, Robert Mansberg
A 58-year-old man was referred for selective internal radiation therapy for locally advanced unresectable hepatocellular carcinoma. Intra-arterial particle perfusion scintigraphy was performed with SPECT/CT following intra-arterial injection of Tc macroaggregated albumin. Angiography demonstrated a hepatic falciform artery, a feeding artery of the ligamentum teres, whereas scintigraphy demonstrated tracer uptake in the mid-anterior abdominal wall. The hepatic falciform artery was subsequently embolized and the repeat angiogram confirmed successful occlusion...
November 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29166246/imaging-features-of-gadoxetic-acid-enhanced-and-diffusion-weighted-mr-imaging-for-identifying-cytokeratin-19-positive-hepatocellular-carcinoma-a-retrospective-observational-study
#5
Seo-Youn Choi, Seong Hyun Kim, Cheol Keun Park, Ji Hye Min, Ji Eun Lee, Yoon-Hyeong Choi, Bo Ra Lee
Purpose To determine the preoperative magnetic resonance (MR) imaging findings potentially most useful for predicting cytokeratin 19 (CK19)-positive hepatocellular carcinoma (HCC) and to evaluate the prognosis after curative resection in patients with a single HCC lesion positive for CK19 compared with patients with HCC who are negative for CK19. Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Two hundred four patients with CK19-negative HCC and 38 with CK19-positive HCC who underwent curative resection after gadoxetic acid-enhanced and diffusion-weighted MR imaging were retrospectively evaluated in a single institution...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29166245/evidence-supporting-li-rads-major-features-for-ct-and-mr-imaging-based-diagnosis-of-hepatocellular-carcinoma-a-systematic-review
#6
An Tang, Mustafa R Bashir, Michael T Corwin, Irene Cruite, Christoph F Dietrich, Richard K G Do, Eric C Ehman, Kathryn J Fowler, Hero K Hussain, Reena C Jha, Adib R Karam, Adrija Mamidipalli, Robert M Marks, Donald G Mitchell, Tara A Morgan, Michael A Ohliger, Amol Shah, Kim-Nhien Vu, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC to imaging-detected liver observations based on major and ancillary imaging features. LI-RADS also includes imaging features suggesting malignancy other than HCC. Supported and endorsed by the American College of Radiology (ACR), the system has been developed by a committee of radiologists, hepatologists, pathologists, surgeons, lexicon experts, and ACR staff, with input from the American Association for the Study of Liver Diseases and the Organ Procurement Transplantation Network/United Network for Organ Sharing...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29165831/external-validation-of-the-ita-li-ca-prognostic-system-for-patients-with-hepatocellular-carcinoma-a-multicenter-cohort-study-hep-17-0903
#7
Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari
Several staging systems for HCC have been developed. BCLC is considered the best in predicting survival, although limitations have emerged. Recently the Italian-Liver-Cancer (ITA.LI.CA) prognostic system, integrating the ITA.LI.CA tumor-staging (stages 0, A, B1-3; C) with Child-Pugh score, ECOG-PST, and AFP with a strong ability to predict survival was proposed. Aim of our study was to provide an external validation of the ITA.LI.CA system in an independent real-life occidental cohort of HCCs. METHODS: From September 2008 to April 2016, 1508 cirrhotics with incident HCC were consecutively enrolled in 27 Italian institutions (EpaHCC multi-institutional cohort)...
November 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29165812/a-novel-and-validated-prognostic-nomogram-based-on-liver-fibrosis-and-tumor-burden-for-patients-with-hepatocellular-carcinoma-after-curative-resection
#8
Jin-Long Huang, Yi-Peng Fu, Chu-Yu Jing, Yong Yi, Jian Sun, Wei Gan, Zhu-Feng Lu, Jian Zhou, Jia Fan, Shuang-Jian Qiu
BACKGROUND AND OBJECTIVES: Most conventional staging systems were formulated concerning the tumor burden rather than the severity of liver fibrosis, which plays a central role in tumor promotion. The aim of this study was to formulate a prognostic nomogram comprehensively considering these two aspects for HCC after hepatectomy. METHODS: The prognostic significances of the four indicators namely laminin, hyaluronic acid, human procollagen type-III, and collagen type-IV that reflect liver fibrosis were explored in two independent cohorts...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165041/akt-mediated-phosphorylation-of-atg4b-impairs-mitochondrial-activity-and-enhances-the-warburg-effect-in-hepatocellular-carcinoma-cells
#9
Zhenhong Ni, Jintao He, Yaran Wu, Changjiang Hu, Xufang Dai, Xiaojing Yan, Bo Li, Xinzhe Li, Haojun Xiong, Yuming Li, Song Li, Liang Xu, Yongsheng Li, Jiqin Lian, Fengtian He
Phosphorylation is a major type of post-translational modification, which can influence the cellular physiological function. ATG4B, a key macroautophagy/autophagy-related protein, has a potential effect on the survival of tumor cells. However, it is still unknown as to the role of ATG4B phosphorylation in cancers. In this study, we identified a novel phosphorylation site at Ser34 of ATG4B induced by AKT in HCC cells. The phosphorylation of ATG4B at Ser34 had little effect on autophagic flux, but promoted the Warburg effect including the increase of L-lactate production and glucose consumption, and the decrease of oxygen consumption in HCC cells...
November 22, 2017: Autophagy
https://www.readbyqxmd.com/read/29164842/tumor-suppressor-role-of-mir-503
#10
Gaurav Gupta, Dinesh K Chellappan, Terezinha de Jesus Andreoli Pinto, Philip M Hansbro, Mary Bebawy, Kamal Dua
MicroRNAs (miRNAs) are noncoding RNAs of around 20-25 nucleotides in length with highly conserved characteristics. They moderate posttranscriptional silencing by precisely combining with 3' untranslated regions (UTRs) of target mRNAs at a complementary site. miR503, an associate of the "canonical" miRNA16 family, is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma and several others. There is convincing evidence to show that miR503 functions as a tumor suppressor gene through its effects on target genes that regulate cell proliferation, migration, and invasion in tumor cells...
November 22, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/29164767/the-association-between-steatosis-and-diabetes-with-hepatocellular-carcinoma-in-non-genotype-3-chronic-hepatitis-c-patients
#11
Yi-Hao Yen, Ming-Tsung Lin, Fang-Ying Kuo, Kuo-Chin Chang, Ming-Chao Tsai, Po-Lin Tseng, Cheng-Kun Wu, Jung-Ting Lin, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen
BACKGROUND AND AIMS: Diabetes mellitus (DM) has been found to be strongly associated with an increased risk of hepatocellular carcinoma (HCC) among chronic hepatitis C (CHC) patients. Several studies have also found an association between metabolic steatosis and the risk of HCC in CHC patients, whether this latter association has been accounted for by the known relationship between DM and HCC is still unknown. METHODS: A cohort consisting of 976 non-genotype 3 patients histologically proven to have CHC and treated with interferon and ribavirin was studied...
November 22, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29164575/long-non-coding-rna-xloc_010235-correlates-with-poor-prognosis-and-promotes-tumorigenesis-of-hepatocellular-carcinoma
#12
F Yang, Y Jiang, L-Z Lv
OBJECTIVE: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Long non-coding RNAs (lncRNAs) are novel proposed non-coding RNAs, and play critical roles in tumorigenesis. However, the clinical significance, biological role and molecular mechanism of ncRNAs in HCC still remain largely elusive. The aim of this study was to uncover the clinical value and biological role of XLOC_010235 (XLOC), which has been demonstrated as an oncogene in gastric cancer, in HCC...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164488/spontaneous-elimination-of-hepatitis-c-virus-infection
#13
Maciej Janiak, Kamila Caraballo Cortes, Urszula Demkow, Marek Radkowski
Hepatitis C virus (HCV) is the etiological agent of chronic hepatitis C and a major cause of liver cirrhosis and hepatocellular carcinoma. Only a minority of infected individuals can clear the virus spontaneously. The knowledge of the determinants of virus clearance would allow the development of effective methods preventing its further spread and optimizing treatment regimens. Viral factors associated with spontaneous virus clearance in the acute phase of infection, such as HCV genotype, virus heterogeneity, and the impact of viral proteins on the immune system have been characterized...
November 22, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29164400/hepatitis-c-virus-infection-among-illicit-drug-users-in-an-archipelago-of-the-amazon
#14
Fabricio Q Silva, Francisco J A Santos, Andreia P Andrade, Suzy D B Pacheco, Benedikt Fischer, João Renato R Pinho, José Alexandre R Lemos, Aldemir B Oliveira-Filho
Hepatitis C virus (HCV) infection causes acute and chronic liver disease and may lead to cirrhosis, liver failure or hepatocellular carcinoma. The behavior of illicit drug users (DUs) typically exposes them to risks of viral infection. In the Brazilian Amazon region, a number of studies have identified high rates of drug use among adolescents, and a high prevalence of HBV infection in DUs, disseminated by sexual and parenteral activities. However, the epidemiological scenario of HCV infection in the region is still poorly understood...
November 21, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29163965/use-of-inhibitors-of-the-renin-angiotensin-system-is-associated-with-longer-survival-in-patients-with-hepatocellular-carcinoma
#15
Matthias Pinter, Arndt Weinmann, Marcus-Alexander Wörns, Florian Hucke, Simona Bota, Jens U Marquardt, Dan G Duda, Rakesh K Jain, Peter R Galle, Michael Trauner, Markus Peck-Radosavljevic, Wolfgang Sieghart
Background: Inhibition of the renin-angiotensin system (RAS) was associated with longer survival in patients with different solid malignancies. Objective: The objective of this study was to investigate the effect of RAS inhibitor (RASi) treatment (angiotensin-converting enzyme inhibitors or angiotensin-II-receptor blockers) on survival of patients with hepatocellular carcinoma (HCC). Methods: Patients diagnosed with HCC and Child-Pugh A between 1992 and 2013 who received sorafenib, experimental therapy, or best supportive care were eligible for the Vienna cohort...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163959/the-gut-microbiota-a-new-potential-driving-force-in-liver-cirrhosis-and-hepatocellular-carcinoma
#16
REVIEW
Marco Sanduzzi Zamparelli, Alba Rocco, Debora Compare, Gerardo Nardone
The gut microbiota has recently been recognized as a major environmental factor in the pathophysiology of many human diseases. The anatomical and function connection existing between gut and liver provides the theoretical basis to assume the liver is a major target for gut microbes. In the last decades, numerous studies reported an altered composition of gut microbiota in patients with liver cirrhosis and a progressively marked dysbiosis with worsening of the liver disease. The risk of developing hepatocellular carcinoma, the deadliest complication of liver cirrhosis, is widely variable among cirrhotic patients, thus suggesting a complexity of genetic and environmental factors implicated in hepatocarcinogenesis...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163838/combining-des-gamma-carboxyprothrombin-and-alpha-fetoprotein-for-hepatocellular-carcinoma-diagnosing-an-update-meta-analysis-and-validation-study
#17
Huaping Chen, Siyuan Chen, Shan Li, Zhijian Chen, Xuan Zhu, Meiyu Dai, Lingxi Kong, Xiaodan Lv, Zhili Huang, Xue Qin
Controversies about the combination of des-gamma-carboxyprothrombin (DCP) and alpha-fetoprotein (AFP) for hepatocellular carcinoma diagnosing still exist. Hence, we performed this updated meta-analysis to estimate the diagnostic value of DCP , AFP and DCP + AFP in HCC. In addition, we conducted a validation study to analyze the performance of the candidate makers. After a systematic literature review, 27 studies from 20 articles were identified from four major databases. The pooled sensitivity and specificity were 69% and 89%, respectively, for DCP; for AFP, they were 65% and 88%, respectively; and they were 82% and 85%, respectively, for DCP + AFP...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163834/prognostic-value-of-c-met-overexpression-in-hepatocellular-carcinoma-a-meta-analysis-and-review
#18
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim, Hyun Joo Jang, Jin Lee
The overexpression of c-Met protein has been detected in hepatocellular carcinoma (HCC). However, its prognostic impact remains uncertain. We performed this meta-analysis to evaluate the prognostic value of c-Met overexpression in patients who underwent curative surgical resection for HCC. A systematic computerized search of the electronic databases was carried out. From 5 studies, 1,408 patients who underwent surgical resection for HCC were included in the meta-analysis. Compared with patients with HCC having low c-Met expression, patients with c-Met-high tumor showed significantly worse relapse-free survival (hazard ratio = 1...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163828/surrogate-endpoint-for-overall-survival-in-assessment-of-adjuvant-therapies-after-curative-treatment-for-hepatocellular-carcinoma-a-re-analysis-of-meta-analyses-of-individual-patients-data
#19
Hong-Bo Huan, Li-Li Wu, Wan-Yee Lau, Xu-Dong Wen, Liang Zhang, Da-Peng Yang, Xi-Shu Wang, Ping Bie, Feng Xia
The gold standard endpoint to evaluate the effect of treatment for hepatocellular carcinoma (HCC) is overall survival (OS), but it requires a longer follow-up period to observe. This study aimed to identify whether disease-free survival (DFS) could be used as a surrogate endpoint for OS to assess the efficacy of adjuvant therapies after curative treatment (surgical resection and ablation) for HCC patients. A systematic review was conducted to identify trials about curative treatment combined with or without adjuvant therapies (interferon, IFN; or transarterial chemoembolization, TACE) for HCC...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163804/circulating-tumor-cells-as-liquid-biomarker-for-high-hcc-recurrence-risk-after-curative-liver-resection
#20
Johann von Felden, Kornelius Schulze, Till Krech, Florian Ewald, Björn Nashan, Klaus Pantel, Ansgar W Lohse, Sabine Riethdorf, Henning Wege
Background: Early hepatocellular carcinoma (HCC) has a limited prognosis due to recurrence rates of more than 50% after liver resection. Recurrence within two years is believed to be caused by untraceable micro metastases at the time of resection. The objective of this study was to investigate EpCAM-positive circulating tumor cells (CTC) as liquid biomarker to identify patients with high risk of recurrence after liver resection. Methods: 61 patients undergoing resection between 2011 and 2015 were consecutively enrolled...
October 27, 2017: Oncotarget
keyword
keyword
56368
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"