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https://www.readbyqxmd.com/read/28317588/applicability-of-endoscopic-submucosal-dissection-for-undifferentiated-early-gastric-cancer-mixed-histology-of-poorly-differentiated-adenocarcinoma-and-signet-ring-cell-carcinoma-is-a-worse-predictive-factor-of-nodal-metastasis
#1
In Seob Lee, Sol Lee, Young Soo Park, Chung Sik Gong, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) is not considered an appropriate treatment for undifferentiated early gastric cancer (UEGC) due to the higher risk of nodal metastases. We aimed to investigate predictive factors for nodal metastases in UEGCs, determine whether the tumor histology is an independent factor for it, and explore whether ESD is applicable for UEGC. METHODS: We reviewed the medical records of 1837 patients who underwent curative gastrectomy for poorly differentiated adenocarcinoma, signet ring cell carcinoma, and a mixed type of both tumors between 2008 and 2012...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28316225/-the-clinical-impact-of-artery-first-approach-combined-with-vascular-resection-and-reconstruction-in-the-treatment-of-pancreatic-head-carcinoma
#2
J L Huang, W G Li, F Z Chen, Z J Su, F M Li, B Liu
Objective: To evaluate the application of artery first, combined vascular resection and reconstruction in the treatment of pancreatic head carcinoma. Methods: The clinical data of 13 patients with pancreatic head cancer were retrospectively analyzed from February 2014 to March 2016 in the Affiliated Hospital of Xiamen University. Preoperative computed tomography of high resolution layer or magnetic resonance imaging examination demonstrated pancreatic head carcinoma, as well as close adhesion, stenosis, compression or displacement of superior mesenteric vein or portal vein wall...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28315766/bone-morphogenetic-protein-4-is-overexpressed-in-and-promotes-migration-and-invasion-of-drug-resistant-cancer-cells
#3
Kairui Zhou, Xiaoli Shi, Jinling Huo, Weihua Liu, Dongxiao Yang, Tengjiao Yang, Tiantian Qin, Cong Wang
Drug resistance and metastasis significantly hinder chemotherapy and worsen prognoses in cancer. Bone morphogenetic protein 4 (BMP4) belongs to the TGF-β superfamily, has broad biological activities in cell proliferation and cartilage differentiation and is also able to induce migration and invasion. Herein, we investigated the role of BMP4 in the regulation of metastasis in paclitaxel-resistant human esophageal carcinoma EC109 cells (EC109/Taxol) and docetaxel-resistant human gastric cancer MGC803 cells (MGC/Doc)...
March 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28315691/mir-519-suppresses-nasopharyngeal-carcinoma-cell-proliferation-by-targeting-oncogene-urg4-urgcp
#4
Guodong Yu, Tian Zhang, Ying Jing, Qingmin Bao, Qiang Tang, Yu Zhang
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumor in Southeast Asia, its regulatory mechanism is still to be understood. miR-519 inhibits the progression of several tumors, including cervical cancer, ovarian cancer and gastric cancer. But its role in NPC hasn't been studied. In present study, we found miR-519 was downregulated in NPC cells, its overexpression inhibited NPC cell proliferation and arrested cell cycle at G0/G1 phase, while its knockdown promoted NPC cell proliferation and cell cycle progression...
March 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28303873/-transhiatal-esophagectomy-for-cardia-and-esophagus-cancer
#5
A Yu Moiseev, A M Shulutko, S E Gryaznov
AIM: To present the result of transhiatal esophagectomies with simultaneous repair. MATERIAL AND METHODS: The study included 67 procedures. In 35 cases surgery was carried out for adenocarcinoma of distal esophagus or cardia with high transition to esophagus, in 32 cases - for epidermal carcinoma of the esophagus. Gastric graft and left half of the colon were used in 60 and 7 cases respectively for simultaneous repair. 29 patients underwent transhiatal instrumental esophagectomy using author's original technique...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28300576/clinical-significance-of-spasmolytic-polypeptide-expressing-metaplasia-and-intestinal-metaplasia-in-ebv-associated-and-ebv-negative-gastric-cancer
#6
Yu Zhang, Jian-Ning Chen, Min Dong, Zhi-Gang Zhang, Yi-Wang Zhang, Jun-Yan Wu, Hong Du, Hai-Gang Li, Yan Huang, Chun-Kui Shao
Spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia (IM) have been recognized as neoplastic precursors in gastric carcinogenesis. We explored the relationship between SPEM and IM in Epstein-Barr virus-associated (EBVaGC) and Epstein-Barr virus-negative (EBVnGC) gastric cancer. 64 EBVaGC and 154 EBVnGC patients were included. EBV-positivity was identified using EBER-1 in situ hybridization. SPEM was sub-classified into absent, early and advanced SPEM. Acute and chronic inflammation was graded as absent, mild, moderate and marked...
March 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/28299580/the-expression-of-hdac7-in-cancerous-gastric-tissues-is-positively-associated-with-distant-metastasis-and-poor-patient-prognosis
#7
Y Yu, F Cao, X Yu, P Zhou, Q Di, J Lei, Y Tai, H Wu, X Li, X Wang, W Zhang, P Li, Y Li
PURPOSE: To characterize the expression patterns of HDAC7 in patients with gastric cancer and evaluate the prognostic value of HDAC7 in gastric cancer. METHODS: The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, and the differences in the expression of HDAC7 between cancerous and corresponding adjacent noncancerous tissues were compared using the Wilcoxon matched-pairs signed rank test...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28297783/-a-case-of-gastric-carcinoma-with-primary-malignant-melanoma-of-the-liver
#8
Y L Qi, Y Zhang, L D Zhao, W Li, B Z Ma, Q L Gao
No abstract text is available yet for this article.
January 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28296678/endocervical-adenocarcinoma-with-morphologic-features-of-both-usual-and-gastric-types-clinicopathologic-and-immunohistochemical-analyses-and-high-risk-hpv-detection-by-in-situ-hybridization
#9
Tomoko Wada, Yoshihiro Ohishi, Tsunehisa Kaku, Murasaki Aman, Hiroko Imamura, Nobuko Yasutake, Kenzo Sonoda, Kiyoko Kato, Yoshinao Oda
The fourth edition of the World Health Organization classification set up new entities of endocervical adenocarcinoma (ECA), namely the "usual type" and "gastric type." These 2 types are considered to be distinct histogenetically because of their differing immunophenotypes, human papillomavirus (HPV) status, and prognoses. Usual-type ECAs (U-ECAs) are virtually always associated with high-risk human papillomavirus (HR-HPV) infection. Gastric-type ECAs (G-ECAs) are believed not to be associated with HR-HPV infection...
March 14, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28293120/glucocorticoid-receptor-expression-in-20-solid-tumor-types-using-immunohistochemistry-assay
#10
Thaddeus S Block, Tiffany I Murphy, Pamela N Munster, Dat P Nguyen, Frank J Lynch
BACKGROUND: Glucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors. A novel immunohistochemistry (IHC) based assay has been previously developed and validated in order to assess GR immunoreactivity in triple-negative breast cancer. The current study investigates the standardized use of this validated assay to assess GR expression in a broad range of solid tumor malignancies...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28288188/evaluations-of-primary-lesions-by-endoscopy-clearly-distinguishes-prognosis-in-patients-with-gastric-cancer-who-receive-chemotherapy
#11
Tomomitsu Tahara, Tomoyuki Shibata, Masaaki Okubo, Tomohiko Kawamura, Noriyuki Horiguchi, Dai Yoshida, Takamitsu Ishizuka, Mitsuo Nagasaka, Yoshihito Nakagawa, Naoki Ohmiya
BACKGROUND: Chemotherapy may improve outcomes in gastric cancer (GC), especially for the patients with advanced stage. To explore useful predictive factor for GC performing chemotherapy, we compared the tumor responses assessed using computed tomography (CT) with endoscopy based criteria. METHODS: 192 GC patients performing chemotherapy were retrospectively studied. CT based response assessment was performed after 2 courses of treatment. Endoscopic evaluation according to The Japanese classification of gastric carcinoma was also performed at same period...
2017: PloS One
https://www.readbyqxmd.com/read/28281974/silencing-of-atp4b-of-atpase-h-k-transporting-beta-subunit-by-intragenic-epigenetic-alteration-in-human-gastric-cancer-cells
#12
Shuye Lin, Bonan Lin, Xiaoyue Wang, Yuanming Pan, Qing Xu, Jin-Shen He, Wanghua Gong, Rui Xing, Yuqi He, Lihua Guo, Youyong Lu, Ji Ming Wang, Jiaqiang Huang
The ATPase H+/K+ Transporting Beta Subunit (ATP4B) encodes the β subunit of the gastric H+, K+-ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site...
March 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28280631/gastric-metastasis-of-bilateral-breast-cancer
#13
Omar Jmour, Asma Belaïd, Fahmi Mghirbi, Khalil Béhi, Raoudha Doghri, Farouk Benna
Breast cancer is the most common malignancy in women. The most frequent metastatic sites are lung, bone, liver and brain. On the other hand, gastric metastases are rare. Synchronous bilateral breast cancer (SBBC) occurs rarely. Lobular carcinoma is the histological type most often associated with bilateral breast carcinomas and gastric metastases. We made a retrospective study including four patients followed in the Salah Azaiez Institute, for a bilateral breast cancer with gastric metastases. We analyzed the epidemiological, anatomoclinical and therapeutic particularities of this rare entity...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28280619/prognostic-value-of-diffuse-versus-intestinal-histotype-in-patients-with-gastric-cancer-a-systematic-review-and-meta-analysis
#14
Fausto Petrelli, Rosa Berenato, Luca Turati, Alessia Mennitto, Francesca Steccanella, Marta Caporale, Pierpaolo Dallera, Filippo de Braud, Ezio Pezzica, Maria Di Bartolomeo, Giovanni Sgroi, Vincenzo Mazzaferro, Filippo Pietrantonio, Sandro Barni
BACKGROUND: There are two distinct types of gastric carcinoma (GC), intestinal, more frequently sporadic and linked to environmental factors, and diffuse (undifferentiated) that is highly metastatic and characterized by rapid disease progression and a poor prognosis. However, there are many conflicting data in the literature concerning the association between histology and prognosis in GC. This meta-analysis was performed to provide demonstration if histology according to Lauren classification is associated with different prognosis in patients with GC...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28280618/clinicopathologic-study-of-neuroendocrine-tumors-of-gastroenteropancreatic-tract-a-single-institutional-experience
#15
Megha S Uppin, Shantveer G Uppin, Chittiboyina Shiva Prasada Venkata Sunil, Monalisa Hui, Tara Roshni Paul, Nagari Bheerappa
BACKGROUND: The gastroenteropancreatic neuroendocrine tumors (GEPNET) have a characteristic histologic appearance unrelated of the exact site of origin. However the behavior of these tumors are different in each of these sites. In this article we study the clinicopathological features of GEPNET. These tumors were classified and graded according to WHO 2010 criteria. The immunohistochemical (IHC) features were evaluated and the grade of the tumor was correlated with Ki67. METHODS: A total of 40 cases of GEPNET diagnosed on biopsies as well as resected specimens were analyzed from January 2012 to June 2015...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28279462/screening-and-preventive-strategies-in-esophagogastric-cancer
#16
REVIEW
Liam Zakko, Lori Lutzke, Kenneth K Wang
Gastric adenocarcinoma, esophageal adenocarcinoma, and esophageal squamous cell carcinoma are among the most prevalent and deadly of malignancies worldwide. Screening and prevention programs will be critical to finally improving outcomes in these diseases. For gastric adenocarcinoma, screening in high-risk populations has significantly reduced mortality. More research is needed on screening high-risk individuals in low-risk populations. For esophageal adenocarcinoma, work is needed to develop efficient and effective techniques in mass screening programs...
April 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28276285/gastric-conduit-obstruction-due-to-gastroduodenal-compression-a-new-complication-post-ivor-lewis-oesophagectomy
#17
Victoria A Perkins, Samuel McFerran, Ali Kordzadeh, Elias Sdralis, Bruno Lorenzi, Alexandros Charalabopoulos
INTRODUCTION: Oesophagectomy for oesophageal carcinoma carries a high risk of significant morbidity and mortality. Delayed gastric emptying is a relatively common complication following this procedure. A variety of medical, surgical and endoscopic strategies have been described to manage it. The vast majority of cases are related to post-operative pyloric dysfunction and are amenable to conventional management strategies. PATIENTS AND METHODS: We present a new case of a patient with a duodenal hiatus hernia resulting in extrinsic gastroduodenal compression by the massively distended gastric conduit as a cause of gastric outlet obstruction following laparoscopic-assisted Ivor-Lewis oesophagectomy 2 years previously...
March 9, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28276033/effect-of-neoadjuvant-chemotherapy-on-her-2-expression-in-surgically-treated-gastric-and-oesophagogastric-junction-carcinoma-a-multicentre-italian-study
#18
Damiano Chiari, Elena Orsenigo, Giovanni Guarneri, Gian Luca Baiocchi, Elena Mazza, Luca Albarello, Massimiliano Bissolati, Sarah Molfino, Carlo Staudacher
Predictors of response to neoadjuvant chemotherapy are not available for gastric and oesophago-gastric junction carcinoma. HER-2 over-expression in breast cancer correlates with poor prognosis and high incidence of recurrence. First aim of this study was to evaluate if the HER-2 expression/amplification is predictive of response to neoadjuvant chemotherapy in terms of pathologic regression. Secondary aim was to evaluate if HER-2 expression varies after neoadjuvant treatment. Thirty-five patients with locally advanced gastric or oesophago-gastric junction carcinoma underwent preoperative chemotherapy and surgical resection at San Raffaele Scientific Institute and Spedali Civili of Brescia...
March 8, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28275487/experiences-in-the-management-of-anastomotic-leakages-and-analysis-of-the-factors-affecting-leakage-healing-in-patients-with-esophagogastric-junction-cancer
#19
Ningning Ding, Yousheng Mao, Jie He, Shugeng Gao, Yue Zhao, Ding Yang, Kelin Sun, Guiyu Cheng, Juwei Mu, Qi Xue, Dali Wang, Jun Zhao, Yushun Gao, Xiangyang Liu, Dekang Fang, Jian Li, Yonggang Wang, Jinfeng Huang, Bing Wang, Liangze Zhang
BACKGROUND: It was reported in the literatures that the incidence of anastomotic leakage in patients with esophagogastric junction cancer decreased due to application of staplers and closure devices as well as gastric conduit technique in recent years, however, it increased slightly at our center since widely using the above devices and gastric conduit techniques from 2009. The objective of this study was to summarize our experiences in the management of anastomotic leakages and analyze the factors affecting leakage healing in the patients with esophagogastric junction cancer after surgical resection in recent 6 years...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28273032/the-efficacy-of-modified-docetaxel-cisplatin-5-fluorouracil-regimen-as-first-line-treatment-in-patients-with-alpha-fetoprotein-producing-gastric-carcinoma
#20
Yakup Bozkaya, Mutlu Doğan, Ozan Yazıcı, Gökmen Umut Erdem, Nebi Serkan Demirci, Nurullah Zengin
Alpha-fetoprotein producing gastric carcinoma (AFP-PGC) is a rare cancer for which limited data on the clinicopathological features and treatment modalities exist. The aim of this study was to compare the efficacy of modified docetaxel-cisplatin-5-fluorouracil (mDCF) as the first-line chemotherapy regimen in metastatic AFP-PGC and non-AFP-PGC. The patients diagnosed with metastatic gastric cancer who were given mDCF as first-line therapy were retrospectively reviewed. The patients with a basal serum AFP level over 9 ng/ml were defined as AFP-PGC patients...
February 25, 2017: Bosnian Journal of Basic Medical Sciences
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