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https://www.readbyqxmd.com/read/29328148/fast-occlusion-processing-for-a-polygon-based-computer-generated-hologram-using-the-slice-by-slice-silhouette-method
#1
Jung-Ping Liu, Heng-Kuang Liao
In a polygon-based computer-generated hologram (CGH), the three-dimensional (3D) model is represented as a polygon, which consists of numerous small facets. Lighting effect, material texture, and surface property can be included in the polygonal model, which enables polygon-based CGH to realize high-fidelity 3D display. On the other hand, the occlusion effect is an important depth cue for 3D display. In polygon-based CGH, however, occlusion processing is difficult and time-consuming work. In this paper, we proposed a simple and fast occlusion processing method, the slice-by-slice silhouette (S3) method, for generating the occlusion effect in polygon-based CGH...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328145/iterative-pixelwise-approach-applied-to-computer-generated-holograms-and-diffractive-optical-elements
#2
Wei-Feng Hsu, Shih-Chih Lin
This paper presents a novel approach to optimizing the design of phase-only computer-generated holograms (CGH) for the creation of binary images in an optical Fourier transform system. Optimization begins by selecting an image pixel with a temporal change in amplitude. The modulated image function undergoes an inverse Fourier transform followed by the imposition of a CGH constraint and the Fourier transform to yield an image function associated with the change in amplitude of the selected pixel. In iterations where the quality of the image is improved, that image function is adopted as the input for the next iteration...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328140/full-color-digitized-holography-for-large-scale-holographic-3d-imaging-of-physical-and-nonphysical-objects
#3
Kyoji Matsushima, Noriaki Sonobe
Digitized holography techniques are used to reconstruct three-dimensional (3D) images of physical objects using large-scale computer-generated holograms (CGHs). The object field is captured at three wavelengths over a wide area at high densities. Synthetic aperture techniques using single sensors are used for image capture in phase-shifting digital holography. The captured object field is incorporated into a virtual 3D scene that includes nonphysical objects, e.g., polygon-meshed CG models. The synthetic object field is optically reconstructed as a large-scale full-color CGH using red-green-blue color filters...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328133/computer-generated-hologram-generation-method-to-increase-the-field-of-view-of-the-reconstructed-image
#4
Su-Juan Liu, Dan Xiao, Xiao-Wei Li, Qiong-Hua Wang
In this paper, a computer-generated hologram (CGH) generation method is proposed to increase the field of view (FOV) in the holographic display. The CGH is generated through accumulating interference patterns of all object points. The size of each interference pattern is equal to the sum of the size of the recorded object and the spatial light modulator (SLM), so the size of the interference pattern is increased. The position of the interference pattern is related to that of the corresponding recorded object point...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29325267/-analysis-of-clinical-outcomes-of-different-embryo-stage-biopsy-in-array-comparative-genomic-hybridization-based-preimplantation-genetic-diagnosis-and-screening
#5
J D Shen, W Wu, L Shu, L L Cai, J Z Xie, L Ma, X P Sun, Y G Cui, J Y Liu
Objective: To evaluate the efficiency of the application of array comparative genomic hybridization (array-CGH) in preimplantation genetic diagnosis or screening (PGD/PGS), and compare the clinical outcomes of different stage embryo biopsy. Methods: The outcomes of 381 PGD/PGS cycles referred in the First Affiliated Hospital of Nanjing Medical University from July 2011 to August 2015 were retrospectively analyzed. There were 320 PGD cycles with 156 cleavage-stage-biopsy cycles and 164 trophectoderm-biopsy cycles, 61 PGS cycles with 23 cleavage-stage-biopsy cycles and 38 trophectoderm-biopsy cycles...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29312578/integrated-analysis-of-chromosome-copy-number-variation-and-gene-expression-in-cervical-carcinoma
#6
Deng Yan, Song Yi, Wang Chi Chiu, Liu Gui Qin, Wong Hoi Kin, Chung Tony Kwok Hung, Han Linxiao, Choy Kwong Wai, Sui Yi, Yang Tao, Tang Tao
Objective: This study was conducted to explore chromosomal copy number variations (CNV) and transcript expression and to examine pathways in cervical pathogenesis using genome-wide high resolution microarrays. Methods: Genome-wide chromosomal CNVs were investigated in 6 cervical cancer cell lines by Human Genome CGH Microarray Kit (4x44K). Gene expression profiles in cervical cancer cell lines, primary cervical carcinoma and normal cervical epithelium tissues were also studied using the Whole Human Genome Microarray Kit (4x44K)...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286390/a-novel-strategy-combining-array-cgh-whole-exome-sequencing-and-in-utero-electroporation-in-rodents-to-identify-causative-genes-for-brain-malformations
#7
Valerio Conti, Aurelie Carabalona, Emilie Pallesi-Pocachard, Richard J Leventer, Fabienne Schaller, Elena Parrini, Agathe A Deparis, Françoise Watrin, Emmanuelle Buhler, Francesca Novara, Stefano Lise, Alistair T Pagnamenta, Usha Kini, Jenny C Taylor, Orsetta Zuffardi, Alfonso Represa, David Antony Keays, Renzo Guerrini, Antonio Falace, Carlos Cardoso
Birth defects that involve the cerebral cortex - also known as malformations of cortical development (MCD) - are important causes of intellectual disability and account for 20-40% of drug-resistant epilepsy in childhood. High-resolution brain imaging has facilitated in vivo identification of a large group of MCD phenotypes. Despite the advances in brain imaging, genomic analysis and generation of animal models, a straightforward workflow to systematically prioritize candidate genes and to test functional effects of putative mutations is missing...
December 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29226546/small-supernumerary-marker-chromosome-15-and-a-ring-chromosome-15-associated-with-a-15q26-3-deletion-excluding-the-igf1r-gene
#8
András Szabó, Márta Czakó, Kinga Hadzsiev, Balázs Duga, Zsolt Bánfai, Katalin Komlósi, Béla Melegh
Array comparative genomic hybridization is essential in the investigation of chromosomal rearrangements associated with epilepsy, intellectual disability, and dysmorphic features. In many cases deletions, duplications, additional marker chromosomes, and ring chromosomes originating from chromosome 15 lead to abnormal phenotypes. We present a child with epilepsy, cardiac symptoms, severely delayed mental and growth development, behavioral disturbances and characteristic dysmorphic features showing a ring chromosome 15 and a small supernumerary marker chromosome...
December 11, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29226086/fibroblasts-promote-the-collective-invasion-of-ameloblastoma-tumor-cells-in-a-3d-coculture-model
#9
Takao Fuchigami, Hirofumi Koyama, Michiko Kishida, Yoshiaki Nishizawa, Mikio Iijima, Toshiro Kibe, Masahiro Ueda, Tohru Kiyono, Yoshimasa Maniwa, Norifumi Nakamura, Shosei Kishida
Ameloblastoma is a benign tumor of the odontogenic epithelium with several histological subtypes. All subtypes of ameloblastoma contain abundant stroma; the tumor cells invade collectively into the surrounding tissues without losing intratumor cell attachments. However, the molecular mechanisms mediating ameloblastoma invasion remain unclear. Here, we evaluated the functional significance of the interactions between ameloblastoma tumor cells and stromal fibroblasts on collective cellular invasion using a three-dimensional cultivation method, double-layered collagen gel hemisphere (DL-CGH) culture...
December 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29221071/ultrafast-layer-based-computer-generated-hologram-calculation-with-sparse-template-holographic-fringe-pattern-for-3-d-object
#10
Hak Gu Kim, Yong Man Ro
In this paper, we propose a new ultrafast layer based CGH calculation that exploits the sparsity of hologram fringe pattern in 3-D object layer. Specifically, we devise a sparse template holographic fringe pattern. The holographic fringe pattern on a depth layer can be rapidly calculated by adding the sparse template holographic fringe patterns at each object point position. Since the size of sparse template holographic fringe pattern is much smaller than that of the CGH plane, the computational load can be significantly reduced...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29219112/haploinsufficiency-of-dmrt-gene-cluster-in-a-case-with-46-xy-ovotesticular-disorder-of-sexual-development
#11
Metin Eser, Akif Ayaz
BACKGROUND: Ovotesticular disorder is characterized by the presence of testicular tissue and ovarian tissue in the same individual. Single gen mutations such as SRY, SOX9, DMRT1 and DAX1 can lead to ovotesticular disorder of sexual development. CASE REPORT: Herein, we reported a 3 month-old phenotypically female detected tissues differentiated both Mullerian duct and Wolffian ducts on pathological analysis of laparoscopic biopsy material. In our case observed 46,XY,der(9)t(3;9)(p25;p24) on chromosomal analysis were detected deletion of 9p24...
December 8, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29191497/recontacting-in-light-of-new-genetic-diagnostic-techniques-for-patients-with-intellectual-disability-feasibility-and-parental-perspectives
#12
Gea Beunders, Melodi Dekker, Oscar Haver, Hanne J Meijers-Heijboer, Lidewij Henneman
A higher diagnostic yield from new diagnostic techniques makes re-evaluation in patients with intellectual disability without a causal diagnosis valuable, and is currently only performed after new referral. Active recontacting might serve a larger group of patients. We aimed to evaluate parental perspectives regarding recontacting and its feasibility in clinical genetic practice. A recontacting pilot was performed in two cohorts of children with intellectual disability. In cohort A, parents were recontacted by phone and in cohort B by letter, to invite them for a re-evaluation due to the new technologies (array CGH and exome sequencing, respectively)...
November 27, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29178642/the-genetic-profile-of-leber-congenital-amaurosis-in-an-australian-cohort
#13
Jennifer A Thompson, John N De Roach, Terri L McLaren, Hannah E Montgomery, Ling H Hoffmann, Isabella R Campbell, Fred K Chen, David A Mackey, Tina M Lamey
BACKGROUND: Leber congenital amaurosis (LCA) is a severe visual impairment responsible for infantile blindness, representing ~5% of all inherited retinal dystrophies. LCA encompasses a group of heterogeneous disorders, with 24 genes currently implicated in pathogenesis. Such clinical and genetic heterogeneity poses great challenges for treatment, with personalized therapies anticipated to be the best treatment candidates. Unraveling the individual genetic etiology of disease is a prerequisite for personalized therapies, and could identify potential treatment candidates, inform patient management, and discriminate syndromic forms of disease...
November 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29177010/7p15-deletion-as-the-cause-of-hand-foot-genital-syndrome-a-case-report-literature-review-and-proposal-of-a-minimum-region-for-this-phenotype
#14
Emiy Yokoyama, Dennise Lesley Smith-Pellegrin, Silvia Sánchez, Bertha Molina, Alfredo Rodríguez, Rocío Juárez, Esther Lieberman, Silvia Avila, José Luis Castrillo, Victoria Del Castillo, Sara Frías
Background: Hand-foot-genital syndrome (HFGS) is a rare condition characterized by congenital malformations in the limbs and genitourinary tract. Generally, this syndrome occurs due to point mutations that cause loss of function of the HOXA13 gene, which is located on 7p15; however, there are some patients with HFGS caused by interstitial deletions in this region. Case presentation: We describe a pediatric Mexican patient who came to the Medical Genetics Department at the National Institute of Pediatrics because he presented with genital, hand and feet anomalies, facial dysmorphisms, and learning difficulties...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29172004/early-onset-myopathies-clinical-findings-prevalence-of-subgroups-and-diagnostic-approach-in-a-single-neuromuscular-referral-center-in-germany
#15
K Vill, A Blaschek, D Gläser, M Kuhn, T Haack, B Alhaddad, M Wagner, R Kovacs-Nagy, M Tacke, L Gerstl, A S Schroeder, I Borggraefe, C Mueller, B Schlotter-Weigel, B Schoser, M C Walter, W Müller-Felber
BACKGROUND: Early-onset myopathies are a heterogeneous group of neuromuscular diseases with broad clinical, genetic and histopathological overlap. The diagnostic approach has considerably changed since high throughput genetic methods (next generation sequencing, NGS) became available. OBJECTIVE: We present diagnostic subgroups in a single neuromuscular referral center and describe an algorithm for the diagnostic work-up. METHODS: The diagnostic approach of 98 index patients was retrospectively analysed...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/29170104/unraveling-unusual-x-chromosome-patterns-during-fragile-x-syndrome-genetic-testing
#16
Gabriella Esposito, Maria Roberta Tremolaterra, Maria Savarese, Michele Spiniello, Maria Pia Patrizio, Barbara Lombardo, Lucio Pastore, Francesco Salvatore, Antonella Carsana
BACKGROUND: Fragile X syndrome (FXS) is the most common form of inherited intellectual disability (ID). Together with fragile X-associated tremor and ataxia (FXTAS) and fragile X-associated premature ovarian failure (POF)/primary ovarian insufficiency (POI), depends on dysfunctional expression of the FMR1 gene on Xq27.3. In most cases, FXS is caused by a >200 CGG repeats in FMR1 5'-untranslated region (UTR) and by promoter hypermethylation that results in gene silencing. Males and females with unmethylated premutated alleles (repeats between 55 and 200) are at risk for FXTAS and POF/POI...
November 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29165356/fast-detection-of-a-brca2-large-genomic-duplication-by-next-generation-sequencing-as-a-single-procedure-a-case-report
#17
Marcella Nunziato, Flavio Starnone, Barbara Lombardo, Matilde Pensabene, Caterina Condello, Francesco Verdesca, Chiara Carlomagno, Sabino De Placido, Lucio Pastore, Francesco Salvatore, Valeria D'Argenio
The aim of this study was to verify the reliability of a next generation sequencing (NGS)-based method as a strategy to detect all possible BRCA mutations, including large genomic rearrangements. Genomic DNA was obtained from a peripheral blood sample provided by a patient from Southern Italy with early onset breast cancer and a family history of diverse cancers. BRCA molecular analysis was performed by NGS, and sequence data were analyzed using two software packages. Comparative genomic hybridization (CGH) array was used as confirmatory method...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29162795/semiconductor-sequencing-analysis-of-chromosomal-copy-number-variations-in-spontaneous-miscarriage
#18
Ming-Zhu Wang, Fang-Qin Lin, Min Li, Dan He, Qi-Hong Yu, Xue-Xi Yang, Ying-Song Wu
BACKGROUND Array CGH is the criterion standard for identifying copy number variations (CNV), but the restrictive requirement of DNA quality and relatively high cost prevent the use of this method as a general assay in hospitals in developing countries. Our principal objective was to determine whether the semiconductor sequencing platform (SSP) could be an alternative method in CNV detection for spontaneous miscarriage. MATERIAL AND METHODS A total of 443 spontaneous miscarriage samples were collected and subjected to low-coverage (0...
November 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29162178/childhood-maltreatment-moderates-the-effect-of-combat-exposure-on-cingulum-structural-integrity
#19
Layla Banihashemi, Meredith L Wallace, Lei K Sheu, Michael C Lee, Peter J Gianaros, Robert P Mackenzie, Salvatore P Insana, Anne Germain, Ryan J Herringa
Limbic white matter pathways link emotion, cognition, and behavior and are potentially malleable to the influences of traumatic events throughout development. However, the impact of interactions between childhood and later life trauma on limbic white matter pathways has yet to be examined. Here, we examined whether childhood maltreatment moderated the effect of combat exposure on diffusion tensor imaging measures within a sample of military veterans (N = 28). We examined five limbic tracts of interest: two components of the cingulum (cingulum, cingulate gyrus, and cingulum hippocampus [CGH]), the uncinate fasciculus, the fornix/stria terminalis, and the anterior limb of the internal capsule...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29158625/comparative-genomic-hybridization-and-transcriptome-sequencing-reveal-that-two-genes-osi_14279-loc_os03g62620-and-osi_10794-loc_os03g14950-regulate-the-mutation-in-the-%C3%AE-rl-rice-mutant
#20
Xulong Wang, Fanhua Wang, Huiqiong Chen, Xiaoyu Liang, Yingmei Huang, Jicai Yi
We previously established the genetic locus of the rolled-leaf mutant, γ-rl, to chromosome 3. In this study, we performed a comparative genomic hybridization (CGH) analysis to identify the genes responsible for the γ-rl mutant phenotype. This was combined with RNA transcriptome sequencing (RNA-seq) to analyze differences in the mRNA expression in seeds 12 h after germination. Using the reference genome of the "indica type" rice from GenBank, we created a chip with 386,000 high density DNA probes designed to target chromosome 3...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
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