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https://www.readbyqxmd.com/read/28622763/treatment-decisions-and-mortality-in-hiv-positive-presumptive-smear-negative-tb-in-the-xpert%C3%A2-mtb-rif-era-a-cohort-study
#1
Sabine M Hermans, Juliet A Babirye, Olive Mbabazi, Francis Kakooza, Robert Colebunders, Barbara Castelnuovo, Christine Sekaggya-Wiltshire, Rosalind Parkes-Ratanshi, Yukari C Manabe
BACKGROUND: The Xpert™ MTB/RIF (XP) has a higher sensitivity than sputum smear microscopy (70% versus 35%) for TB diagnosis and has been endorsed by the WHO for TB high burden countries to increase case finding among HIV co-infected presumptive TB patients. Its impact on the diagnosis of smear-negative TB in a routine care setting is unclear. We determined the change in diagnosis, treatment and mortality of smear-negative presumptive TB with routine use of Xpert MTB/RIF (XP). METHODS: Prospective cohort study of HIV-positive smear-negative presumptive TB patients during a 12-month period after XP implementation in a well-staffed and trained integrated TB/HIV clinic in Kampala, Uganda...
June 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28614446/-factors-associated-with-tb-hiv-coinfection-evidence-from-notification-data-in-the-state-of-amazonas-brazil-2001-2012
#2
Evela da Silva Magno, Valeria Saraceni, Alexandra Brito de Souza, Regma da Silva Magno, Maria das Graças Gomes Saraiva, Samira Bührer-Sékula
Tuberculosis (TB) in persons living with HIV (PLHIV) is the leading infectious cause of AIDS-related death. The aim of this study was to estimate the prevalence of TB/HIV coinfection, evaluate notification of the two diseases over time by probabilistic database linkage, and identify factors associated with AIDS and TB notifications. Prevalence of TB/HIV coinfection was 7.7%. The group of PLHIV with subsequent TB diagnosis was the most representative, despite available preventive measures. Underreporting of TB among AIDS cases was 35%, and 19...
June 12, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28591334/-evaluation-of-implementation-of-the-protocol-for-managing-tuberculosis-human-immunodeficiency-virus-coinfection-in-specialized-care-services-in-cear%C3%A3-state
#3
Silvia Helena Bastos de Paula, Telma Alves Martins, Sheila Maria Santiago Borges, Christiana Maria de Oliveira Nogueira, Valderina Ramos Freire
Objectives: Identify barriers and strategies for implementation of the protocol for managing tuberculosis/ human immunodeficiency virus (TB/HIV) coinfection in specialized care services in Ceará state, through evaluation research. Methods: The study followed iPIER methodology, a new initiative to help improve the implementation of health programs through the use of research that is conducted as a part of the implementation process. Data were collected on the structure and processes of 22 services and barriers were explored in four focus groups with 28 participants, from the standpoint of the health team, administrators, and users...
May 25, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28591330/-access-barriers-to-comprehensive-care-for-people-affected-by-tuberculosis-and-human-immunodeficiency-virus-coinfection-in-peru-2010-2015
#4
Lisset García-Fernández, Carlos Benites, Byelca Huamán
Objective: Identify the programmatic barriers that hinder access to comprehensive care of patients with tuberculosis and human immunodeficiency virus (TB/HIV) coinfection. Methods: This is a mixed-method study. Qualitative research was conducted via in-depth interviews with key actors and the quantitative component involved cross-sectional descriptive analysis of programmatic data from 2010-2015 on tuberculosis and HIV programs at health facilities in the cities of Lima and Iquitos...
May 25, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28499418/early-morning-urine-collection-to-improve-urinary-lateral-flow-lam-assay-sensitivity-in-hospitalised-patients-with-hiv-tb-co-infection
#5
Phindile Gina, Philippa J Randall, Tapuwa E Muchinga, Anil Pooran, Richard Meldau, Jonny G Peter, Keertan Dheda
BACKGROUND: Urine LAM testing has been approved by the WHO for use in hospitalised patients with advanced immunosuppression. However, sensitivity remains suboptimal. We therefore examined the incremental diagnostic sensitivity of early morning urine (EMU) versus random urine sampling using the Determine® lateral flow lipoarabinomannan assay (LF-LAM) in HIV-TB co-infected patients. METHODS: Consenting HIV-infected inpatients, screened as part of a larger prospective randomized controlled trial, that were treated for TB, and could donate matched random and EMU samples were included...
May 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28492776/tuberculosis-mortality-in-brazilian-capitals-2008-2010
#6
Roger Flores Ceccon, Rosana Maffacciolli, Andréia Burille, Stela Nazareth Meneghel, Dora Lúcia Leidens Correa de Oliveira, Tatiana Engel Gerhardt
OBJECTIVE: to analyze the association between tuberculosis mortality and socio-demographics and health indicators in the capitals of Brazilian states and the Federal District. METHODS: this is an ecological study whose outcome was the standardized coefficient of tuberculosis mortality in the 2008-2010 period; the independent variables comprised 16 indicators, grouped into three blocks; Pearson correlation test and multiple linear regression were applied for analysis...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28482959/tuberculosis-in-adolescents-and-young-adults-epidemiology-and-treatment-outcomes-in-the-western-cape
#7
K Snow, A C Hesseling, P Naidoo, S M Graham, J Denholm, K du Preez
SETTING: Western Cape Province, South Africa. OBJECTIVES: To characterise tuberculosis (TB) epidemiology, disease presentation and treatment outcomes among adolescents (age 10-19 years) and young adults (age 20-24 years) in the Western Cape. DESIGN: A retrospective, cross-sectional review of routine patient-level data from the Electronic TB Register (ETR.Net) for 2013. Site of TB disease, human immunodeficiency virus (HIV) status and TB treatment outcomes were analysed by 5-year age groups (<5, 5-9, 10-14, 15-19, 20-24 and 25 years of age)...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28480244/improving-tuberculosis-tb-and-human-immunodeficiency-virus-hiv-treatment-monitoring-in-south-africa-evaluation-of-an-advanced-tb-hiv-course-for-healthcare-workers
#8
Sean Galagan, Suzanne Jed, Jeri Sumitani, Jennifer M Gilvydis, Albert Bakor, Richard Cooke, Evasen Naidoo, Debra Winters, Marcia R Weaver
BACKGROUND: South Africa has dual epidemics of human immunodeficiency virus (HIV) and tuberculosis (TB). Nurse-focused training was combined with onsite mentoring for nurses to improve HIV and TB care. A pre-/postevaluation was conducted in 3 districts in South Africa to assess the effects of the course on clinical patient monitoring and integration of TB and HIV care. METHODS: Two cross-sectional, unmatched samples of patient charts at 76 primary healthcare facilities were collected retrospectively in 2014 to evaluate the impact of training on treatment monitoring...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28465651/factors-associated-with-mortality-of-tb-hiv-co-infected-patients-in-ethiopia
#9
Alula M Teklu, Abiy Nega, Admasu Tenna Mamuye, Yohannes Sitotaw, Desta Kassa, Getnet Mesfin, Bekele Belayihun, Girmay Medhin, Kesetebirhan Yirdaw
BACKGROUND: Despite the large number of TB patients on ART in Ethiopia, their mortality remains high. This study reports the effect of TB on HIV related mortality and determinants of TB/HIV co-infection related mortality. METHODS: A longitudinal study design was employed as part of the Advanced Clinical Monitoring of ART (ACM) in Ethiopia. All patients started on ART at or after January 1, 2005 were included. Survival analysis was done to compare survival patterns of HIV patients with TB against HIV patients without TB...
February 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28459881/facilitators-and-barriers-for-retention-in-hiv-care-between-testing-and-treatment-in-asia-a-study-in-bangladesh-indonesia-lao-nepal-pakistan-philippines-and-vietnam
#10
Sushil Koirala, Keshab Deuba, Oranuch Nampaisan, Gaetano Marrone, Anna Mia Ekström
INTRODUCTION: The need for efficient retention in HIV care is more evident than ever because of the expansion of earlier ART initiation and the shift towards 'Test and Treat'. This study assesses factors affecting participation in the HIV care cascade among people living with HIV (PLHIV) in the Asia-Pacific Region. METHODS: A total of 7843 PLHIV aged 18-50 years were recruited using targeted and venue-based sampling between October 1, 2012, and May 31, 2013, across 59 sites in 7 countries (Bangladesh, Indonesia, Lao People's Democratic Republic (Lao PDR), Nepal, Pakistan, Philippines and Vietnam)...
2017: PloS One
https://www.readbyqxmd.com/read/28457751/utility-of-urine-lipoarabinomannan-lam-in-diagnosing-tuberculosis-and-predicting-mortality-with-and-without-hiv-prospective-tb-cohort-from-the-thailand-big-city-tb-research-network
#11
Gompol Suwanpimolkul, Kamon Kawkitinarong, Weerawat Manosuthi, Jiratchaya Sophonphan, Sivaporn Gatechompol, Pirapon June Ohata, Sasiwimol Ubolyam, Thatri Iampornsin, Pairaj Katerattanakul, Anchalee Avihingsanon, Kiat Ruxrungtham
OBJECTIVES: To evaluate the applicability and accuracy of the urine lipoarabinomannan (LAM) test in tuberculosis (TB)/HIV co-infected patients and HIV-negative patients with disseminated TB. METHODS: Frozen urine samples obtained at baseline from patients in the TB research cohort with proven culture-positive TB were selected for blinded urine LAM testing. One hundred and nine patients were categorized into four groups: (1) HIV-positive patients with TB; (2) HIV-negative patients with disseminated TB; (3) HIV-negative immunocompromised patients with TB; and (4) patients with diseases other than TB...
June 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28455104/a-comparison-of-tuberculosis-diagnostic-systems-in-a-retrospective-cohort-of-hiv-infected-children-in-rio-de-janeiro-brazil
#12
Solange Gonçalves David, Kathryn L Lovero, Maria de Fátima B Pombo March, Thalita G Abreu, Antonio Ruffino Netto, Afranio L Kritski, Clemax C Sant'Anna
OBJECTIVES: The diagnosis of pediatric tuberculosis (TB) presents many challenges, and is further complicated in HIV-infected patients. While many diagnostic systems have been proposed, there is no pediatric TB diagnosis gold standard. The outcomes of four TB diagnostic systems in HIV-infected children were compared in this study. METHODS: A retrospective cohort study was conducted at a TB/HIV reference hospital in Rio de Janeiro. HIV-infected pediatric patients evaluated for TB from 1998 to 2010 were reassessed using four diagnostic systems: Kenneth Jones, 1969; Tidjani, 1986; Ben Marais, 2006; Brazilian Ministry of Health, 2010...
April 25, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28444006/scale-up-of-collaborative-tb-hiv-activities-in-guyana
#13
Brian J Baker, Brandy Peterson, Jeetendra Mohanlall, Shanti Singh, Collene Hicks, Ruth Jacobs, Ruth Ramos, Barbara Allen, Eric Pevzner
Objective: To assess scale-up of recommended tuberculosis (TB)/HIV activities in Guyana and to identify specific strategies for further expansion. Methods: Medical records and clinic registers were reviewed at nine TB clinics and 10 HIV clinics. At TB clinics, data were collected on HIV testing and antiretroviral therapy (ART) for patients with TB/HIV; at HIV clinics, data were collected on intensified case finding (ICF), tuberculin skin test (TST) results, and provision of isoniazid preventive therapy (IPT)...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28440604/a-proposed-novel-framework-for-monitoring-and-evaluation-of-the-cascade-of-hiv-associated-tb-care-at-the-health-facility-level
#14
Colleen F Hanrahan, Annelies Van Rie
INTRODUCTION: The rapid and accurate diagnosis of HIV-associated tuberculosis (TB), timely initiation of curative or preventative treatment and assurance of favourable treatment outcomes is a complex process. The current system of monitoring and reporting TB diagnosis and treatment does not include several key aspects of the care cascade, and may obscure systematic bottlenecks, inefficiencies or sources of sub-optimal care. METHODS: We critically reviewed the current World Health Organizations recommended system of monitoring and reporting, and identified the following key deficiencies that could limit the ability of healthcare workers to identify structural problems in the provision of TB/HIV care...
April 20, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28438139/digital-cxr-with-computer-aided-diagnosis-versus-symptom-screen-to-define-presumptive-tuberculosis-among-household-contacts-and-impact-on-tuberculosis-diagnosis
#15
Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya, Helen Ayles
BACKGROUND: Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However, this strategy may be limited due to poor performance in predicting TB. The objective of this study was to compare CXR with Computer Aided Diagnosis (CAD) against symptom screen for defining presumptive TB and how TB detection changes with each method. METHODS: Household contacts of consecutive index bacteriologically confirmed TB cases were visited by study teams and given TB/HIV education to raise awareness of the risk of TB following close contact with a TB patient...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28392916/treatment-outcomes-of-tuberculosis-patients-in-nigist-eleni-mohammed-general-hospital-hosanna-southern-nations-nationalities-and-peoples-region-ethiopia-a-five-year-june-2009-to-august-2014-retrospective-study
#16
Tigist Mohammed, Kidist Daniel, Degefa Helamo, Taye Leta
BACKGROUND: Tuberculosis remains to be a major public health problem among under developed world due to delay in detection and treatment of patients with active TB. In Ethiopia, tuberculosis has been recognized as a major public health problem for more than fifty years. OBJECTIVE: The main objective of this study was to determine treatment outcomes and associated factors among TB patients attending Nigist Eleni Mohammed General Hospital, Hosanna, SNNPR, Ethiopia...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28392698/assessment-of-isoniazid-preventive-therapy-in-the-reduction-of-tuberculosis-among-art-patients-in-arba-minch-hospital-ethiopia
#17
Ashenafi Abossie, Tsegaye Yohanes
BACKGROUND: Tuberculosis (TB) is the most frequent life-threatening opportunistic disease among people living with HIV and remains a leading cause of mortality, even among persons receiving antiretroviral therapy (ART). Isoniazid preventive therapy (IPT) and cotrimoxazole prophylaxis have been recommended for the benefit of HIV/AIDS-infected individuals to prevent opportunistic infections. The aim of this study was to assess IPT prophylaxis in the reduction of TB among ART patients. METHODS: The study was a hospital-based retrospective study...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28380276/microscopic-observation-drug-susceptibility-assay-vs-xpert-%C3%A2-mtb-rif-for-the-diagnosis-of-tuberculosis-in-a-rural-african-setting-a-cost-utility-analysis
#18
Philip E Wikman-Jorgensen, Jara Llenas-García, Tomàs M Pérez-Porcuna, Michael Hobbins, Jochen Ehmer, Manuel A Mussa, Carlos Ascaso
OBJECTIVE: To compare the cost-utility of microscopic observation drug-susceptibility assay (MODS) and Xpert(®) MTB/RIF implementation for tuberculosis (TB) diagnosis in rural northern Mozambique. METHODS: Stochastic transmission compartmental TB model from the healthcare provider perspective with parameter input from direct measurements, systematic literature reviews and expert opinion. MODS and Xpert(®) MTB/RIF were evaluated as replacement test of smear microscopy (SM) or as an add-on test after a negative SM...
April 5, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28358846/risk-factors-associated-with-tuberculosis-tb-among-people-living-with-hiv-aids-a-pair-matched-case-control-study-in-guangxi-china
#19
Zhezhe Cui, Mei Lin, Shaofa Nie, Rushu Lan
BACKGROUND: As one of the poorest provinces in China, Guangxi has a high HIV and TB prevalence, with the annual number of TB/HIV cases reported by health department among the highest in the country. However, studies on the burden of TB-HIV co-infection and risk factors for active TB among HIV-infected persons in Guangxi have rarely been reported. OBJECTIVE: To investigate the risk factors for active TB among people living with HIV/AIDS in Guangxi Zhuang autonomous region, China...
2017: PloS One
https://www.readbyqxmd.com/read/28356081/the-prevalence-of-hiv-among-adults-with-pulmonary-tb-at-a-population-level-in-zambia
#20
Pascalina Chanda-Kapata, Nathan Kapata, Eveline Klinkenberg, Martin P Grobusch, Frank Cobelens
BACKGROUND: Tuberculosis and HIV co-infection is one of the main drivers of poor outcome for both diseases in Zambia. HIV infection has been found to predict TB infection/disease and TB has been reported as a major cause of death among individuals with HIV. Improving case detection of TB/HIV co-infection has the potential to lead to early treatment of both conditions and can impact positively on treatment outcomes. This study was conducted in order to determine the HIV prevalence among adults with tuberculosis in a national prevalence survey setting in Zambia, 2013-2014...
March 29, 2017: BMC Infectious Diseases
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