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https://www.readbyqxmd.com/read/28928173/cohort-profile-of-a-study-on-outcomes-related-to-tuberculosis-and-antiretroviral-drug-concentrations-in-uganda-design-methods-and-patient-characteristics-of-the-south-study
#1
Christine Sekaggya-Wiltshire, Barbara Castelnuovo, Amrei von Braun, Joseph Musaazi, Daniel Muller, Allan Buzibye, Ursula Gutteck, Lars Henning, Bruno Ledergerber, Natascia Corti, Mohammed Lamorde, Jan Fehr, Andrew Kambugu
PURPOSE: Tuberculosis (TB) is a leading cause of death among people living with HIV in sub-Saharan Africa. Several factors influence the efficacy of TB treatment by leading to suboptimal drug concentrations and subsequently affecting treatment outcome. The aim of this cohort is to determine the association between anti-TB drug concentrations and TB treatment outcomes. PARTICIPANTS: Patients diagnosed with new pulmonary TB at the integrated TB-HIV outpatient clinic in Kampala, Uganda, were enrolled into the study and started on first-line anti-TB treatment...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28919720/text-messaging-to-decrease-tuberculosis-treatment-attrition-in-tb-hiv-coinfection-in-uganda
#2
Sabine M Hermans, Sawsan Elbireer, Harriet Tibakabikoba, Bas J Hoefman, Yukari C Manabe
BACKGROUND: Low tuberculosis (TB) treatment completion rates in sub-Saharan Africa are an important driver of multidrug resistance. Mobile technology-based interventions have been shown to improve adherence to antiretroviral therapy in sub-Saharan Africa. We aimed to test the effect of a short-message service (SMS) intervention on loss to follow-up (LFU). MATERIALS AND METHODS: In this quasi-experimental study, all adult, literate, HIV-infected patients with mobile phone access diagnosed with TB between November 2010 and October 2011 in an urban clinic in Uganda were eligible to receive adherence and appointment reminders and educational quizzes during the first 8 weeks of TB treatment...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28911357/pulmonary-tuberculosis-diagnostic-practices-among-people-living-with-the-human-immunodeficiency-virus-in-lesotho
#3
D E O'Connor, K Frederix, S Saito, L B Maama, Y Hirsch-Moverman, B Pitt, E Hayes-Larson, L Lebelo, M Shale, A A Howard
SETTING: Twelve health facilities in Berea District, Lesotho, that participated in the Start TB Patients on ART and Retain on Treatment (START) Study, a mixed-methods cluster-randomized trial evaluating a combination intervention package to improve early initiation of antiretroviral therapy (ART) and anti-tuberculosis treatment success among patients with tuberculosis (TB) and human immunodeficiency virus (HIV). OBJECTIVE: To assess TB and HIV diagnostic practices among TB-HIV patients...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28911356/high-completion-rates-of-isoniazid-preventive-therapy-among-persons-living-with-hiv-in-swaziland
#4
L V Adams, N Mahlalela, E A Talbot, M Pasipamire, S Ginindza, M Calnan, S Haumba
SETTING: Five human immunodeficiency virus (HIV) care facilities in Swaziland. OBJECTIVE: To assess adherence and treatment completion of a 6-month course of isoniazid preventive therapy (IPT) provided to HIV-infected patients through a self-selected model of facility-based, community-based or peer-supported IPT delivery coordinated with antiretroviral refills. DESIGN: Prospective cohort study. RESULTS: Between February and August 2015, we enrolled 908 patients, with follow-up until February 2016...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28903800/predicting-treatment-failure-death-and-drug-resistance-using-a-computed-risk-score-among-newly-diagnosed-tb-patients-in-tamaulipas-mexico
#5
B E Abdelbary, M Garcia-Viveros, H Ramirez-Oropesa, M H Rahbar, B I Restrepo
The purpose of this study was to develop a method for identifying newly diagnosed tuberculosis (TB) patients at risk for TB adverse events in Tamaulipas, Mexico. Surveillance data between 2006 and 2013 (8431 subjects) was used to develop risk scores based on predictive modelling. The final models revealed that TB patients failing their treatment regimen were more likely to have at most a primary school education, multi-drug resistance (MDR)-TB, and few to moderate bacilli on acid-fast bacilli smear. TB patients who died were more likely to be older males with MDR-TB, HIV, malnutrition, and reporting excessive alcohol use...
September 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28903727/uptake-of-health-services-among-truck-drivers-in-south-africa-analysis-of-routine-data-from-nine-roadside-wellness-centres
#6
Samanta Tresha Lalla-Edward, Sydney Ncube, Paul Matthew, Catherine A Hankins, W D Francois Venter, Gabriela B Gomez
BACKGROUND: Long-distance truck drivers are occupationally susceptible to poor health outcomes. Their patterns of healthcare utilisation and the suitability of healthcare services available to them are not well documented. We report on truck driver healthcare utilisation across South Africa and characterise the client population of the clinics serving them for future service development. METHODS: We analysed anonymised data routinely collected over a two-year period at nine Roadside Wellness Centres...
September 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28883510/disseminated-tuberculosis-among-hospitalised-hiv-patients-in-south-africa-a-common-condition-that-can-be-rapidly-diagnosed-using-urine-based-assays
#7
Andrew D Kerkhoff, David A Barr, Charlotte Schutz, Rosie Burton, Mark P Nicol, Stephen D Lawn, Graeme Meintjes
HIV-associated disseminated TB (tuberculosis) has been under-recognised and poorly characterised. Blood culture is the gold-standard diagnostic test, but is expensive, slow, and may under-diagnose TB dissemination. In a cohort of hospitalised HIV patients, we aimed to report the prevalence of TB-blood-culture positivity, performance of rapid diagnostics as diagnostic surrogates, and better characterise the clinical phenotype of disseminated TB. HIV-inpatients were systematically investigated using sputum, urine and blood testing...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877156/performance-of-the-quantiferon-tb-gold-assay-among-hiv-infected-children-with-active-tuberculosis-in-france
#8
Myriam Hormi, Valérie Guérin-El Khourouj, Virginie Pommelet, Mohamed Jeljeli, Béatrice Pédron, Jean-Sébastien Diana, Albert Faye, Ghislaine Sterkers
BACKGROUND: Data regarding the use of QuantiFERON to assist the diagnosis of active tuberculosis (TB) in HIV-infected children is limited, especially in countries with low incidence of TB/HIV co-infection. METHODS: QuantiFERON results were analyzed in 63 HIV-infected children who presented to our hospital in Paris, France. Seventeen HIV-uninfected children with active TB (4 culture-confirmed) were included for comparison. RESULTS: The 63 HIV-infected children (median age: 11 years) had 113 QuantiFERON tests...
September 5, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28874142/risk-factors-for-increased-immune-reconstitution-in-response-to-mycobacterium-tuberculosis-antigens-in-tuberculosis-hiv-infected-antiretroviral-na%C3%A3-ve-patients
#9
Tatiana Pereira da Silva, Carmem Beatriz Wagner Giacoia-Gripp, Carolina A Schmaltz, Flavia Marinho Sant'Anna, Maria Helena Saad, Juliana Arruda de Matos, Julio Castro Alves de Lima E Silva, Valeria Cavalcanti Rolla, Mariza Gonçalves Morgado
BACKGROUND: Little is known regarding the restoration of the specific immune response after combined antiretroviral therapy (cART) and anti-tuberculosis (TB) therapy introduction among TB-HIV patients. In this study, we examined the immune response of TB-HIV patients to Mycobacterium tuberculosis (Mtb) antigens to evaluate the response dynamics to different antigens over time. Moreover, we also evaluated the influence of two different doses of efavirenz and the factors associated with immune reconstitution...
September 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28855504/biosynthesis-of-ilamycins-featuring-unusual-building-blocks-and-engineered-production-of-enhanced-anti-tuberculosis-agents
#10
Junying Ma, Hongbo Huang, Yunchang Xie, Zhiyong Liu, Jin Zhao, Chunyan Zhang, Yanxi Jia, Yun Zhang, Hua Zhang, Tianyu Zhang, Jianhua Ju
Tuberculosis remains one of the world's deadliest communicable diseases, novel anti-tuberculosis agents are urgently needed due to severe drug resistance and the co-epidemic of tuberculosis/human immunodeficiency virus. Here, we show the isolation of six anti-mycobacterial ilamycin congeners (1-6) bearing rare L-3-nitro-tyrosine and L-2-amino-4-hexenoic acid structural units from the deep sea-derived Streptomyces atratus SCSIO ZH16. The biosynthesis of the rare L-3-nitrotyrosine and L-2-amino-4-hexenoic acid units as well as three pre-tailoring and two post-tailoring steps are probed in the ilamycin biosynthetic machinery through a series of gene inactivation, precursor chemical complementation, isotope-labeled precursor feeding experiments, as well as structural elucidation of three intermediates (6-8) from the respective mutants...
August 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28837654/immune-characterization-of-the-hbha-specific-response-in-mycobacterium-tuberculosis-infected-patients-with-or-without-hiv-infection
#11
Teresa Chiacchio, Giovanni Delogu, Valentina Vanini, Gilda Cuzzi, Flavio De Maio, Carmela Pinnetti, Alessandro Sampaolesi, Andrea Antinori, Delia Goletti
INTRODUCTION: RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active tuberculosis (TB) disease. Conversely, a positive response to heparin-binding haemagglutinin (HBHA)-based IGRAs, among TB-infected subjects, correlates with Mycobacterium tuberculosis (Mtb) containment and low risk of TB progression. The aim of this study was to characterize HBHA-immune responses in HIV-infected and uninfected subjects with active TB or latent TB infection (LTBI). METHODS: 49 subjects were prospectively enrolled: 22 HIV-uninfected (13 TB, 9 LTBI) and 27 HIV-infected (12 HIV-TB, 15 HIV-LTBI)...
2017: PloS One
https://www.readbyqxmd.com/read/28798367/epidemiology-of-tuberculosis-in-chongqing-china-a-secular-trend-from-1992-to-2015
#12
Bo Wu, Ya Yu, Weijia Xie, Ying Liu, Yao Zhang, Daiyu Hu, Yafei Li
Chongqing is a southwest city of China with high tuberculosis (TB) burden. An observational retrospective study has been performed based on routine TB surveillance data in Chongqing from 1992 to 2015. The TB notification rate has declined to 70.8 cases per 100,000 population from the peak of 106 cases per 100,000 in 2005. The TB notification rate in population over-65 years has become the highest among all-ages population since 2010. The average proportion of farmers in all notified cases from 2008 to 2015 was 62...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743648/drug-resistance-and-mycobacterium-tuberculosis-strain-diversity-in-tb-hiv-co-infected-patients-in-ho-chi-minh-city-vietnam
#13
Trinh Quynh Mai, Nguyen Thi Van Anh, Nguyen Tran Hien, Nguyen Huu Lan, Do Chau Giang, Pham Thi Thu Hang, Nguyen Thi Ngoc Lan, Ben J Marais, Vitali Sintchenko
BACKGROUND: Mycobacterium tuberculosis strain diversity and drug resistance among people living with human immunodeficiency virus (HIV) in Vietnam have not been described previously. METHODS: We examined M. tuberculosis isolates from TB/HIV co-infected patients in Ho Chi Minh City, Vietnam. Drug susceptibility testing (DST), spoligotyping and 24-locus Mycobacterial Interspersed Repetitive Unit (MIRU-24 typing) were performed, and the rpoB, katG, inhA and inhA promoter, rpsL, rrs and embB genes were sequenced in all drug resistant isolates identified...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28739225/distribution-scheme-of-anti-tuberculosis-drug-resistance-among-hiv-patients-in-a-referral-center-over-10-years
#14
Parvaneh Baghaei, Payam Tabarsi, Afshin Moniri, Majid Marjani, Parissa Farnia, Sayena Jabbehdari, Ali Akbar Velayati
OBJECTIVES: Anti-tuberculosis (TB) drug resistance is increasing among TB patients globally, particularly, in those that are human immunodeficiency virus (HIV) positive. The aim of this study was to determine the pattern of anti-TB drug resistance in these patients in an effort to improve successful treatment outcomes with a proper regimen. METHODS: A cross-sectional study was conducted on adult TB-HIV patients from 2005 to 2015. The pattern of anti-TB drugs resistance was evaluated among HIV positive patients with and without a history of TB treatment...
July 21, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28724359/the-burden-of-hiv-on-tuberculosis-patients-in-the-volta-region-of-ghana-from-2012-to-2015-implication-for-tuberculosis-control
#15
Eric Osei, Joyce Der, Richard Owusu, Philip Kofie, Wisdom Kudzo Axame
BACKGROUND: The impact of HIV on TB, and the implications for TB control, has been acknowledged as a public health challenge. It is imperative therefore to assess the burden of HIV on TB patients as an indicator for monitoring the control efforts of the two diseases in this part of the world. This study aimed at determining the burden of HIV infection in TB patients. METHODS: We conducted a retrospective review of TB registers in five districts of the Volta Region of Ghana...
July 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28697621/undiagnosed-tuberculosis-in-patients-with-hiv-infection-who-present-with-severe-anaemia-at-a-district-hospital
#16
Mbulelo Mntonintshi, Don O'Mahony, Sikhumbuzo Mabunda, Kakia A F Namugenyi
BACKGROUND: Tuberculosis (TB) is a major cause of severe anaemia in patients with human immunodeficiency virus (HIV) infection in South Africa. However, TB can be difficult to diagnose as it may be extra pulmonary and paucibacillary. AIM: The aim of this study was to investigate undiagnosed TB in patients with HIV infection and severe anaemia and to identify the optimal investigations for diagnosing TB. SETTING: Mthatha General Hospital, a district hospital...
June 30, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28693508/unsuccessful-tb-treatment-outcomes-with-a-focus-on-hiv-co-infected-cases-a-cross-sectional-retrospective-record-review-in-a-high-burdened-province-of-south-africa
#17
M C Engelbrecht, N G Kigozi, P Chikobvu, S Botha, H C J van Rensburg
BACKGROUND: South Africa did not meet the MDG targets to reduce TB prevalence and mortality by 50% by 2015, and the TB cure rate remains below the WHO target of 85%. TB incidence in the country is largely fuelled by the HIV epidemic, and co-infected patients are more likely to have unsuccessful TB treatment outcomes. This paper analyses the demographic and clinical characteristics of new TB patients with unsuccessful treatment outcomes, as well as factors associated with unsuccessful treatment outcomes for HIV co-infected patients...
July 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28690879/epidemiological-characteristics-and-clinical-outcome-of-hiv-related-tuberculosis-in-a-population-of-tb-patients-in-south-western-nigeria
#18
Olugbenga A Olowe, Olufunmilola B Makanjuola, Adeniyi S Adekanmi, Olusola J Adefioye, Rita A Olowe
Tuberculosis (TB) is the second leading cause of death from infectious disease globally with its impact more dramatic in resource limited settings. Individuals with human immunodeficiency virus (HIV) infection who also develop tuberculosis represent a significant challenge to TB control. This study was carried out to determine the prevalence of TB-HIV coinfection and pattern of infection among TB patients. We also compared treatment outcome among coinfected patients with those not coinfected. A six-year retrospective review of records of patients managed at the Tuberculosis Treatment Center of the LAUTECH Teaching Hospital, South-Western Nigeria from January 2009 to December 2014 was carried out...
June 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28670643/factors-associated-with-tb-hiv-co-infection-among-drug-sensitive-tuberculosis-patients-managed-in-a-secondary-health-facility-in-lagos-nigeria
#19
Olusola A Adejumo, Olusoji J Daniel, Andrew F Otesanya, Adebukola A Adegbola, Temitope Femi-Adebayo, Abimbola Bowale, Sunday Adesola, Olugbenga O Kuku, Kehinde O Otemuyiwa, Shafaatu N Oladega, Eze O Johnson, Ayodeji A Falana, Olusola Dawodu, Henry Owuna, Ganiyat Osoba, Adetokunbo Dacosta
BACKGROUND: This study assessed factors associated with TB/HIV co-infection among TB patients managed in a secondary health facility in Lagos Nigeria. MATERIALS AND METHODS: A retrospective review of treatment cards of patients seen at a secondary referral hospital between January 1 2014 and December 31 2014 was conducted. Treatment outcomes and factors associated with TB/HIV co-infection were assessed. RESULTS: Of the 334 records of patients reviewed, the proportion of patients with TB/HIV co-infection was 21...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28652801/outcome-of-tuberculosis-treatment-and-its-predictors-among-hiv-infected-patients-in-southwest-ethiopia
#20
Adane Teshome Kefale, Yeniewa Kerie Anagaw
BACKGROUND: Co-infection with HIV challenges treatment of tuberculosis (TB) and worsens the outcome. This study aimed to assess the outcome of TB treatment and its predictors among HIV infected patients at Mizan-Tepi University Teaching Hospital (MTUTH), Ethiopia. METHODS: Medical records of 188 TB/HIV co-infected patients who attended the TB clinic of MTUTH from September 2012 to December 2015 were reviewed from March 14 to April 1, 2016. The primary endpoints of the study were treatment outcome of TB and its predictors...
2017: International Journal of General Medicine
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