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https://www.readbyqxmd.com/read/29329967/-prevalence-of-hiv-tuberculosis-co-infection-and-hiv-impact-on-patients-with-tuberculosis-in-the-lubumbashi-health-zone-from-2014%C3%A2-to-2015
#1
E N Wa Ilunga, R K Muya, A A Kaponda, C M A Kaput, S M Kalonji, V B Chiribagula, B N Nshikala, A N N'sasi, J-B L Simbi
BACKGROUND: Tuberculosis and HIV/AIDS are a dangerous couple in sub-Saharan Africa. The aim of this paper is to evaluate the prevalence of the co-infection tuberculosis/HIV/AIDS and its impact on issues of tuberculosis patients treated in Lubumbashi Heath Zone (LHZ). MATERIALS AND METHODS: A retrospective and transversal study was conducted through the analysis of tuberculosis patients' data admitted in the tuberculosis Health Centers for Diagnosis and treatment (HCDT) in the LHZ from January 2014 to December 2015...
January 9, 2018: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29313506/prevalence-of-tb-hiv-coinfection-in-antiretroviral-na%C3%A3-ve-patients-at-the-fann-ambulatory-treatment-center-in-dakar
#2
D Ka, N F Ngom Guéye, N Fall, N O Touré-Badiane, N Diop, G Batista, K Ndiaye, C T Ndour, M Seydi, M A Faye
To determine the prevalence of tuberculosis and describe its epidemiological, clinical, paraclinical, and therapeutic characteristics and its outcome in patients with HIV. This retrospective, descriptive, and analytical study examined the records of patients with HIV at our outpatient treatment center and selected those who were antiretroviral-naive and presented tuberculosis between January 2008 and December 2012. Among a total of 757 HIV-positive patients, 76 had tuberculosis, for a prevalence of 10 %. The sex ratio of 1...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29310659/the-impact-of-rural-residence-and-hiv-infection-on-poor-tuberculosis-treatment-outcomes-in-a-large-urban-hospital-a-retrospective-cohort-analysis
#3
Aishatu Lawal Adamu, Muktar H Aliyu, Najiba Aliyu Galadanci, Baba Maiyaki Musa, Umar Muhammad Lawan, Usman Bashir, Ibrahim Abubakar
BACKGROUND: Successful tuberculosis (TB) treatment is essential to effective TB control. TB-HIV coinfection, social determinants and access to services influenced by rural residence can affect treatment outcome. We examined the separate and joint effects of rural residence and HIV infection on poor treatment outcome among patients enrolled in a large TB treatment centre in Kano, Nigeria. METHODS: We retrospectively analysed a cohort of patients with TB enrolled in a large urban TB clinic in northern Nigeria, from January 2010 to December 2014...
January 8, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29297441/tackling-tuberculosis-in-sub-saharan-africa-edctp-achievements-and-the-road-ahead
#4
M A Surette, P Beattie, T Nyirenda, O F Olesen
The European and Developing Countries Clinical Trials Partnership (EDCTP) was established in 2003 to accelerate the development of medical interventions for tuberculosis (TB), human immunodeficiency virus (HIV) and malaria, with a particular focus on Phase II and III clinical trials. Between 2003 and 2015, the first EDCTP programme committed €65.6 million to research on TB and TB-HIV co-infection. The programme made a significant contribution to the first three elements of the DOTS TB control strategy, which mobilised European and African funding for TB-related research and generated important evidence on TB diagnostics and treatment regimens...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297437/test-and-treat-for-tb-hiv
#5
Renee Ridzon
No abstract text is available yet for this article.
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29239900/isoniazid-preventive-therapy-for-people-with-hiv-who-are-heavy-alcohol-drinkers-in-high-tb-hiv-burden-countries-a-risk-benefit-analysis
#6
J Morgan Freiman, Karen R Jacobson, Winnie R Muyindike, C Robert Horsburgh, Jerrold J Ellner, Judith A Hahn, Benjamin P Linas
BACKGROUND: Isoniazid preventive therapy (IPT) reduces mortality among people living with HIV (PLHIV), and is recommended for those without active tuberculosis (TB) symptoms. Heavy alcohol use, however, is contraindicated for liver toxicity concerns. We evaluated the risks and benefits of IPT at antiretroviral therapy (ART) initiation to ART alone for PLHIV who are heavy drinkers in three high TB/HIV burden countries. METHODS: We developed a Markov simulation model to compare ART alone to ART with either 6 or 36 months of IPT for heavy drinking PLHIV enrolling in care in Brazil, India, and Uganda...
December 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29226216/prevalence-and-associated-factors-of-tuberculosis-in-prisons-settings-of-east-gojjam-zone-northwest-ethiopia
#7
Mucheye Gizachew Beza, Emirie Hunegnaw, Moges Tiruneh
Background: Tuberculosis, mainly in prisoners, is a major public health problem in Ethiopia where there is no medical screening during prison admission. This creates scarcity of TB data in such settings. Objective: To determine prevalence and associated factors of TB in prisons in East Gojjam Zone, Northwest Ethiopia. Methods: A cross-sectional study was conducted from February to May 2016 among 265 prisoners in three prison sites. Sputum was processed using GeneXpert MTB/RIF...
2017: International Journal of Bacteriology
https://www.readbyqxmd.com/read/29158866/-tb-hiv-co-infection-associated-with-kaposi-s-sarcoma-under-opioid-substitution-treatment-using-methadone-about-a-case
#8
Viviane Marie Pierre Cisse Diallo, Louise Fortes Deguenonvo, Khardiata Diallo Mbaye, Daye Ka, Ndeye Aissatou Lakhe, Ibrahima Ndiaye, Daouda Thioub, Sylvie Audrey Diop Nyafouna, Aminata Massaly, Alassane Dièye, Moustapha Diop, Cheikh Tidiane Ndour, Moussa Seydi
Late diagnosis of HIV infection can be fatal because it favors the appearance of opportunistic infections whose management requires the use of several molecules which can cause drug interactions. We report the case of a 45-year old female patient under heroin substitution treatment, using methadone and with HIV1 under antiretroviral treatment. This patient had nonspecific pulmonary appearance associated with dry nagging cough and progressive dyspnea evolving in a feverish context. Moreover, clinical examination showed left lower limb lymphedema with painless angiomatous nodules evolving over three years associated with plaques, angiomatous nodules occurred more recently at the level of the anterior face of the thorax...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29157275/the-prevent-study-to-evaluate-the-effectiveness-and-acceptability-of-a-community-based-intervention-to-prevent-childhood-tuberculosis-in-lesotho-study-protocol-for-a-cluster-randomized-controlled-trial
#9
Yael Hirsch-Moverman, Andrea A Howard, Koen Frederix, Limakatso Lebelo, Anneke Hesseling, Sharon Nachman, Joanne E Mantell, Tsepang Lekhela, Llang Bridget Maama, Wafaa M El-Sadr
BACKGROUND: Effective, evidence-based interventions to prevent childhood tuberculosis (TB) in high TB/HIV-burden, resource-limited settings are urgently needed. There is limited implementation of evidence-based contact management strategies, including isoniazid preventive therapy (IPT), for child contacts of TB cases in Lesotho. METHODS/DESIGN: This mixed-methods implementation science study utilizes a two-arm cluster-randomized trial design with randomization at the health facility level...
November 21, 2017: Trials
https://www.readbyqxmd.com/read/29141727/point-of-care-ultrasound-for-extrapulmonary-tuberculosis-in-india-a-prospective-cohort-study-in-hiv-positive-and-hiv-negative-presumptive-tuberculosis-patients
#10
Stefan F Weber, Kavitha Saravu, Tom Heller, Rajagopal Kadavigere, Shashidhar Vishwanath, Stephan Gehring, Sabine Bélard, And Pocus Eti Study Group
Diagnosing extrapulmonary tuberculosis (EPTB) is challenging. Point-of-care ultrasound (POCUS) for human immunodeficiency virus (HIV)-associated EPTB is applied in sub-Saharan Africa. This study aimed at evaluating the applicability of POCUS for diagnosing EPTB in HIV-positive and HIV-negative presumptive tuberculosis (TB) patients in India, a country of moderate relative TB and HIV burden. Presumptive TB patients at Kasturba Hospital, Manipal, India, prospectively underwent POCUS evaluating for pericardial, pleural and ascitic effusion, abdominal lymphadenopathy, and hepatic and splenic microabscesses...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29132380/addressing-challenges-in-scaling-up-tb-and-hiv-treatment-integration-in-rural-primary-healthcare-clinics-in-south-africa-suthi-a-cluster-randomized-controlled-trial-protocol
#11
Kogieleum Naidoo, Santhanalakshmi Gengiah, Nonhlanhla Yende-Zuma, Nesri Padayatchi, Pierre Barker, Andrew Nunn, Priashni Subrayen, Salim S Abdool Karim
BACKGROUND: A large and compelling clinical evidence base has shown that integrated TB and HIV services leads to reduction in human immunodeficiency virus (HIV)- and tuberculosis (TB)-associated mortality and morbidity. Despite official policies and guidelines recommending TB and HIV care integration, its poor implementation has resulted in TB and HIV remaining the commonest causes of death in several countries in sub-Saharan Africa, including South Africa. This study aims to reduce mortality due to TB-HIV co-infection through a quality improvement strategy for scaling up of TB and HIV treatment integration in rural primary healthcare clinics in South Africa...
November 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29132287/a-qualitative-analysis-of-the-barriers-to-antiretroviral-therapy-initiation-among-children-2-to-18-months-of-age-in-swaziland
#12
Charisse V Ahmed, Pauline Jolly, Luz Padilla, Musa Malinga, Chantal Harris, Nobuhle Mthethwa, Inessa Ba, Amy Styles, Sarah Perry, Raina Brooks, Florence Naluyinda-Kitabire, Makhosini Mamba, Peter Preko
HIV/AIDS remains one of the leading causes of death among children under 5 years old in Swaziland. Although studies have shown that early initiation of infants and children diagnosed with HIV on antiretroviral therapy (ART) significantly reduces mortality, many children do not initiate ART until the later stages of disease. This study was designed to collect qualitative data from mothers and caregivers of HIV-positive children to identify the barriers to ART initiation. Focus group discussion (FGD) sessions were conducted in siSwati between July and September 2014 among caregivers of aged children 2-18 months in Swaziland who did or did not initiate ART between January 2011 and December 2012 after HIV DNA PCR-positive diagnosis of the infants...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29066256/-treatment-outcome-survival-and-their-risk-factors-among-new-tuberculosis-patients-co-infected-with-hiv-during-the-ebola-outbreak-in-conakry
#13
A Camara, M S Sow, A Touré, O H Diallo, I Kaba, B Bah, T H Diallo, M S Diallo, T Guilavogui, O Y Sow
BACKGROUND: Mortality among TB/HIV co-infected patients remains high in Africa. The study aimed to estimate survival and associated factors in a cohort of TB/HIV co-infected patients who started tuberculosis treatment during the Ebola outbreak in Conakry, Guinea. METHODS: A prospective cohort study was conducted from April 2014 to December 2015. TB patients with HIV co-infection were enrolled at the University Hospital of Conakry. Survival and risk factors were analyzed according to Kaplan-Meier's method, log-rank test and Cox's regression...
November 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29065873/high-variability-of-tb-hiv-hepatitis-c-treatment-and-opioid-substitution-therapy-among-prisoners-in-germany
#14
Jana Müller, Daniel Schmidt, Christian Kollan, Marc Lehmann, Viviane Bremer, Ruth Zimmermann
BACKGROUND: In Germany, medical care of prisoners is completely separated from extramural health care. The extent and quality of medical care among prisoners in Germany are therefore largely unknown. We performed a secondary data analysis of pharmacy sales data for tuberculosis (TB), HIV, hepatitis C (HCV) and opioid substitution treatment (OST) delivered to prisons in 11 federal states (FS) in Germany between 01/2012 and 03/2013. The aims of this study were to assess (i) the treatment availability for the selected diseases and OST in German prisons, (ii) the proportion of prisoners treated per FS and overall for TB, HIV, HCV and OST during the study period...
October 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29061336/management-of-mdr-tb-in-hiv-co-infected-patients-in-eastern-europe-results-from-the-tb-hiv-study
#15
A M W Efsen, A Schultze, R F Miller, A Panteleev, A Skrahin, D N Podlekareva, J M Miro, E Girardi, H Furrer, M H Losso, J Toibaro, J A Caylà, A Mocroft, J D Lundgren, F A Post, O Kirk
OBJECTIVES: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce. METHODS: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART). RESULTS: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB...
October 20, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29040303/continuing-professional-development-for-medical-nursing-and-midwifery-cadres-in-malawi-tanzania-and-south-africa-a-qualitative-evaluation
#16
Caryl Feldacker, Jillian Pintye, Sheena Jacob, Michael H Chung, Lyn Middleton, Jill Iliffe, H Nina Kim
BACKGROUND: As innovations in the prevention and treatment of HIV and TB advance, continuing professional development (CPD) of health care workers (HCWs) remains a high priority, particularly in sub-Saharan Africa where dual TB/HIV epidemics are compounded by severe HCW shortages. There is further need to examine CPD programs to identify challenges and effective solutions to strengthen HIV/TB-related CPD. METHODS: Qualitative evaluations in Malawi, Tanzania and South Africa (RSA) were conducted using key informant interviews (KIIs) and focus group discussions (FGDs) in each country to identify barriers and enablers of effective HIV/TB-related CPD...
2017: PloS One
https://www.readbyqxmd.com/read/29036618/unsuccessful-treatment-in-pulmonary-tuberculosis-factors-and-a-consequent-predictive-model
#17
Ana Costa-Veiga, Teodoro Briz, Carla Nunes
Background: Cure is particularly valuable in pulmonary cases (PTB), as unsuccessful treatment fuels incidence and resistance to antibiotics. This study aims to identify individual factors of PTB unsuccessful treatment in Portugal and to develop a consequent predictive model. Methods: Using the Portuguese TB surveillance database (SVIG-TB), PTB cases older than 15 years notified from 2000 to 2012 in Continental Portugal were analyzed. Unsuccessful treatment included the WHO categories (failure, default, death and transferred out)...
October 3, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29028223/are-scientific-research-outputs-aligned-with-national-policy-makers-priorities-a-case-study-of-tuberculosis-in-cambodia
#18
Lydia Boudarene, Richard James, Richard Coker, Mishal S Khan
With funding for tuberculosis (TB) research decreasing, and the high global disease burden persisting, there are calls for increased investment in TB research. However, justification of such investments is questionable, when translation of research outputs into policy and health care improvements remains a challenge for TB and other diseases. Using TB in Cambodia as a case study, we investigate how evidence needs of national policy makers are addressed by topics covered in research publications. We first conducted a systematic review to compile all studies on TB in Cambodia published since 2000...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29025483/depressive-symptoms-and-hazardous-harmful-alcohol-use-are-prevalent-and-correlate-with-stigma-among-tb-hiv-patients-in-lesotho
#19
E Hayes-Larson, Y Hirsch-Moverman, S Saito, K Frederix, B Pitt, L Maama-Maime, A A Howard
SETTING: Limited data exist on the prevalence and correlates, including stigma, of mental health conditions, including depressive symptoms and alcohol use, among patients co-infected with tuberculosis (TB) and the human immunodeficiency virus (HIV) in sub-Saharan Africa, despite their negative impact on health outcomes. OBJECTIVE: To assess the prevalence and correlates of depressive symptoms and hazardous/harmful alcohol use among TB-HIV patients in the Start TB patients on ART and Retain on Treatment (START) study...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29025480/correlates-of-observing-and-willingness-to-report-stigma-towards-hiv-clients-by-tb-health-workers-in-africa
#20
M Straetemans, M I Bakker, E M H Mitchell
SETTING: Health care facilities in Kenya, Tanzania and Namibia. OBJECTIVE: To study the factors associated with the observation of and willingness to report stigmatising behaviour towards persons living with the human immunodeficiency virus (HIV) among health care workers (HCWs). DESIGN: Mixed-effect logistic regression analyses of 9516 HCW interviews, including those of 4062 (43%) TB workers carried out as part of the Service Provision Assessments (SPAs) between 2006 and 2010...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
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