Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Victor Bass, Jaanam Gopalakrishnan, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Lauren Reich, Chen Yao, Hong-Wei Sun, Stephen R Brooks, Kan Jiang, Vijayaraj Nagarajan, Yongbing Zhao, Seolkyoung Jung, Rachael Phillips, Yohei Mikami, Caleb A Lareau, Yuka Kanno, Dragana Jankovic, Martin J Aryee, Aleksandra Pękowska, Yasmine Belkaid, John O'Shea, Han-Yu Shih
Cytokine expression during T cell differentiation is a highly regulated process that involves long-range promoter-enhancer and CTCF-CTCF contacts at cytokine loci. Here, we investigated the impact of dynamic chromatin loop formation within the topologically associating domain (TAD) in regulating the expression of interferon gamma (IFN-γ) and interleukin-22 (IL-22); these cytokine loci are closely located in the genome and are associated with complex enhancer landscapes, which are selectively active in type 1 and type 3 lymphocytes...
April 26, 2024: Immunity