Read by QxMD icon Read

dynamic contrast enhanced

Feng Feng, Fulin Qiang, Aijun Shen, Donghui Shi, Aiyan Fu, Haiming Li, Mingzhu Zhang, Ganlin Xia, Peng Cao
Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with that of18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules (SPNs). Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs...
February 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Richard Potts, Anna K Behrensmeyer, J Tyler Faith, Christian A Tryon, Alison S Brooks, John E Yellen, Alan L Deino, Rahab Kinyanjui, Jennifer B Clark, Catherine Haradon, Naomi E Levin, Hanneke J M Meijer, Elizabeth G Veatch, R Bernhart Owen, Robin W Renaut
Development of the African Middle Stone Age (MSA) before 300 thousand years ago (ka) raises the question of how environmental change influenced the evolution of behaviors characteristic of early Homo sapiens We use temporally well-constrained sedimentological and paleoenvironmental data to investigate environmental dynamics before and after the appearance of the early MSA in the Olorgesailie Basin, Kenya. In contrast to the Acheulean archeological record in the same basin, MSA sites are associated with a dramatically different faunal community, more pronounced erosion-deposition cycles, tectonic activity, and enhanced wet-dry variability...
March 15, 2018: Science
Shotaro Kanao, Masako Kataoka, Mami Iima, Debra Masako Ikeda, Masakazu Toi, Kaori Togashi
OBJECTIVES: Benign and malignant inflammatory breast lesions demonstrate similar findings on both T2 weighted imaging (T2WI) and dynamic contrast enhanced (DCE) images. We hypothesized that benign inflammatory lesions might be differentiated form malignancies using a combination of apparent diffusion coefficient (ADC) values derived from diffusion weighted images (DWI) and T2WI. MATERIALS AND METHODS: We retrospectively reviewed 162 patients undergoing breast MRI (T2WI, DWI and DCE images) between 2008 and 2015 who had breast lesions with high T2WI signal intensity (High T2 SI) including 14 benign inflammatory lesions, 69 benign non-inflammatory lesions, 16 malignant inflammatory lesions and 63 malignant non-inflammatory lesions...
March 12, 2018: Magnetic Resonance Imaging
Margarita Braunagel, Florian Ortner, Ulf Schönermarck, Antje Habicht, Andreas Schindler, Manfred Stangl, Frederik F Strobl, Maximilian Reiser, Dirk A Clevert, Christoph Trumm, Andreas Helck
RATIONALE AND OBJECTIVE: The objective of this study was to assess an optimized renal multiphase computed tomography angiography (MP-CTA) protocol regarding reduction of contrast volume. MATERIALS AND METHODS: Thirty patients underwent MP-CTA (12 phases, every 3.5 seconds, 80 kV/120 mAs) using 30 mL of contrast medium. The quality of MP-CTA was assessed quantitatively measuring vessel attenuation, image noise, and contrast-to-noise ratio. MP-CTA was evaluated qualitatively regarding depiction of vessels, cortex differentiation, and motion artifacts (grades 1-4, 1 = best)...
March 12, 2018: Academic Radiology
Simon P Overeem, Esmé J Donselaar, Jorrit T Boersen, Erik Groot Jebbink, Cornelis H Slump, Jean-Paul P M de Vries, Michel M P J Reijnen
PURPOSE: To assess the dynamic behavior of chimney grafts during the cardiac cycle. METHODS: Three chimney endovascular aneurysm repair (EVAR) stent-graft configurations (Endurant and Advanta V12, Endurant and Viabahn, and Endurant and BeGraft) were placed in silicone aneurysm models and subjected to physiologic flow. Electrocardiography (ECG)-gated contrast-enhanced computed tomography was used to visualize geometric changes during the cardiac cycle. Endograft and chimney graft surface, gutter volume, chimney graft angulation over the center lumen line, and the D-ratio (the ratio between the lengths of the major and minor axes) were independently assessed by 2 observers at 10 time points in the cardiac cycle...
March 1, 2018: Journal of Endovascular Therapy
Jianguo Li, Roger Beuerman, Chandra Verma
Molecular aggregation plays a significant role in modulating the solubility, permeability, and bioactivity of drugs. The propensity to aggregate depends on hydrophobicity and on molecular shape. Molecular dynamics simulations coupled with enhanced sampling methods are used to explore the early stages of oligomerization of two drug molecules which have a strong aggregation propensity, but with contrasting molecule shapes: the antibiotic ciprofloxacin and the anticancer drug Nutlin-3A. The planar shape of ciprofloxacin induces the formation of stable oligomers at all cluster sizes...
March 14, 2018: Journal of Chemical Physics
Edmund Burke, Sanjeev A Datar
PURPOSE OF REVIEW: The essential role of the lymphatic system in fluid homeostasis, nutrient transport, and immune trafficking is well recognized; however, there is limited understanding of the mechanisms that regulate lymphatic function, particularly in the setting of critical illness. The lymphatics likely affect disease severity and progression in every condition, from severe systemic inflammatory states to respiratory failure. Here, we review structural and functional disorders of the lymphatic system, both congenital and acquired, as they relate to care of the pediatric patient in the intensive care setting, including novel areas of research into medical and procedural therapeutic interventions...
March 13, 2018: Current Opinion in Pediatrics
Amir Pourmorteza, Noemie Keller, Richard Chen, Albert Lardo, Henry Halperin, Marcus Y Chen, Elliot McVeigh
Resting regional wall motion abnormality (RWMA) has significant prognostic value beyond the findings of computed tomography (CT) coronary angiography. Stretch quantification of endocardial engraved zones (SQUEEZ) has been proposed as a measure of regional cardiac function. The purpose of the work reported here was to determine the effect of lowering the radiation dose on the precision of automatic SQUEEZ assessments of RWMA. Chronic myocardial infarction was created by a 2-h occlusion of the left anterior descending coronary artery in 10 swine (heart rates 80-100, ejection fraction 25-57%)...
March 13, 2018: International Journal of Cardiovascular Imaging
Lejo Johnson Chacko, Dominik T Schmidbauer, Stephan Handschuh, Alen Reka, Karl D Fritscher, Patrik Raudaschl, Rami Saba, Michael Handler, Peter P Schier, Daniel Baumgarten, Natalie Fischer, Elisabeth J Pechriggl, Erich Brenner, Romed Hoermann, Rudolf Glueckert, Anneliese Schrott-Fischer
Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. High resolution X-ray microtomography images at 15 μm voxel-size were manually segmented...
2018: Frontiers in Neuroscience
Thais Roque, Laurent Risser, Veerle Kersemans, Sean Smart, Danny Allen, Paul Kinchesh, Stuart Gilchrist, Ana L Gomes, Julia A Schnabel, Michael A Chappell
Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular tumor growth. The model allows for proliferation, death and spread of tumor cells, and accounts for nutrient distribution and hypoxia. It is constrained by longitudinal time series of dynamic contrast-enhancement-MRI images. Tumor specific parameters are estimated from two early time points and used to predict the spatio-temporal evolution of the tumor volume and cell densities at later time points...
March 2018: IEEE Transactions on Medical Imaging
Ellen S Deutsch
Physician psychological wellness is an emergent outcome resulting from dynamic interactions among complex conditions. We may enhance opportunities for physician wellness by applying principles developed to improve another emergent outcome: patient safety. The Safety I approach to patient safety focuses on "what went wrong" and considers humans a liability. Safety II is a powerful complementary approach that focuses on "what went right" and values human creativity. These contrasting perspectives are described in the context of patient safety, but the underlying principles have relevance for physician psychological wellness...
March 1, 2018: Otolaryngology—Head and Neck Surgery
Zhaosheng Zhang, Weihai Fang, Marina Tokina, Run Long, Oleg V Prezhdo
Two-dimensional (2D) Ruddlesden-Popper halide perovskites are appealing candidates for optoelectronics and photovoltaics. Nonradiative electron-hole recombination constitutes a major pathway for charge and energy losses in these materials. Surprisingly, experimental recombination is slower in multi-layers than mono-layer, even though multi-layer systems have smaller energy gaps and higher frequency phonons that should accelerate the recombination. Focusing on (BA)2(MA)n-1PbnI3n+1 with n=1 and 3, BA=CH3(CH2)3NH3 and MA=CH3NH3, we show that it is the enhancement of elastic electron-phonon scattering that suppresses charge recombination for n=3, by causing rapid loss of electronic coherence...
March 13, 2018: Nano Letters
Qingdi Quentin Li, Huei-Fung Tsai, Ajeet Mandal, Bryan A Walker, Jason A Noble, Yuichi Fukuda, John E Bennett
Pathogenic fungi, including Candida glabrata, develop strategies to grow and survive both in vitro and in vivo under azole stress. However, the mechanisms by which yeast cells counteract the inhibitory effects of azoles are not completely understood. In the current study, it was demonstrated that the expression of the ergosterol biosynthetic genes ERG2, ERG3, ERG4, ERG10, and ERG11 was significantly upregulated in C. glabrata following fluconazole treatment. Inhibiting ergosterol biosynthesis using fluconazole also increased the expression of the sterol influx transporter AUS1 and the sterol metabolism regulators SUT1 and UPC2 in fungal cells...
March 9, 2018: Molecular Medicine Reports
Wataru Jomoto, Masao Tanooka, Hiroshi Doi, Keisuke Kikuchi, Chiemi Mitsuie, Yusuke Yamada, Toru Suzuki, Toshiko Yamano, Reiichi Ishikura, Noriko Kotoura, Shingo Yamamoto
We sought to develop a surgical navigation system using magnetic resonance angiography (MRA) and a three-dimensional (3D) printer for robot-assisted radical prostatectomy (RARP). Six patients with pathologically proven localized prostate cancer were prospectively enrolled in this study. Prostate magnetic resonance imaging (MRI), consisting of T2-weighted sampling perfection with application-optimized contrasts using different flip-angle evolutions (SPACE) and true fast imaging with steady-state precession (true FISP), reconstructed by volume rendering, was followed by dynamic contrast-enhanced MRA performed with a volumetric interpolated breath-hold examination (VIBE) during intravenous bolus injection of gadobutrol...
January 2, 2018: Curēus
Rasha Elmghirbi, Tavarekere N Nagaraja, Stephen L Brown, Kelly A Keenan, Swayamprava Panda, Glauber Cabral, Hassan Bagher-Ebadian, George W Divine, Ian Y Lee, James R Ewing
PURPOSE: This study demonstrates a DCE-MRI estimate of tumor interstitial fluid pressure (TIFP) and hydraulic conductivity in a rat model of glioblastoma, with validation against an invasive wick-in-needle (WIN) technique. An elevated TIFP is considered a mark of aggressiveness, and a decreased TIFP a predictor of response to therapy. METHODS: The DCE-MRI studies were conducted in 36 athymic rats (controls and posttreatment animals) with implanted U251 cerebral tumors, and with TIFP measured using a WIN method...
March 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
T D London, J A Licholai, I Szczot, M A Ali, K H LeBlanc, W C Fobbs, A V Kravitz
The striatum controls food-related actions and consumption and is linked to feeding disorders including obesity and anorexia nervosa. Two populations of neurons project from the striatum: direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs). The selective contribution of dMSNs and iMSNs to food-related actions and consumption remains unknown. Here, we used in vivo electrophysiology and fiber photometry in mice (of both sexes) to record both spiking activity and pathway-specific calcium activity of dorsal striatal neurons during approach to and consumption of food pellets...
March 9, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Mark Gainey, Montserrat Carles, Michael Mix, Philipp T Meyer, Michael Bock, Anca-Ligia Grosu, Dimos Baltas
Recently, there has been an increase in the imaging modalities available for radiotherapy planning and radiotherapy prognostic outcome: dual energy computed tomography (CT; DECT), dynamic contrast enhanced CT, dynamic contrast enhanced magnetic resonance imaging (MRI), diffusion-weighted MRI, positron emission tomography-CT, dynamic contrast enhanced ultrasound, magnetic resonance spectroscopy and positron emission tomography-MR. These techniques enable more precise gross tumor volume definition than CT alone and moreover allow subvolumes within the gross tumor volume to be defined which may be given a boost dose or an individual voxelized dose prescription may be derived...
March 9, 2018: Future Oncology
Ravi Kiran Deevi, Arman Javadi, Jane McClements, Jekaterina Vohhodina, Kienan Savage, Maurice Bernard Loughrey, Emma Evergren, Frederick Charles Campbell
Histological grading provides prognostic stratification of colorectal cancer (CRC) by scoring heterogeneous phenotypes. Features of aggressiveness include aberrant mitotic spindle configurations, chromosomal breakage, and bizarre multicellular morphology, but pathobiology is poorly understood. Protein kinase C zeta (PKCz) controls mitotic spindle dynamics, chromosome segregation, and multicellular patterns, but its role in CRC phenotype evolution remains unclear. Here, we show that PKCz couples genome segregation to multicellular morphology through control of interphase centrosome anchoring...
March 9, 2018: Journal of Pathology
Henry J Alitto, Daniel L Rathbun, Tucker G Fisher, Prescott C Alexander, W Martin Usrey
Visual information processed in the retina is transmitted to primary visual cortex via relay cells in the lateral geniculate nucleus (LGN) of the dorsal thalamus. Although retinal ganglion cells are the primary source of driving input to LGN neurons, not all retinal spikes are transmitted to the cortex. Here, we investigate the relationship between stimulus contrast and retinogeniculate communication and test the hypothesis that both the time course and strength of retinogeniculate interactions are dynamic and dependent on stimulus contrast...
March 8, 2018: European Journal of Neuroscience
(no author information available yet)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
March 8, 2018: Scientific Reports
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"