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https://www.readbyqxmd.com/read/28108839/sporadic-insulinomas-on-volume-perfusion-ct-dynamic-enhancement-patterns-and-timing-of-optimal-tumour-parenchyma-contrast
#1
Liang Zhu, Wen-Ming Wu, Hua-Dan Xue, Wei Liu, Xuan Wang, Hao Sun, Ping Li, Yu-Pei Zhao, Zheng-Yu Jin
OBJECTIVES: To assess enhancement patterns of sporadic insulinomas on volume perfusion CT (VPCT), and to identify timing of optimal tumour-parenchyma contrast. METHODS: Consecutive patients who underwent VPCT for clinically suspected insulinomas were retrospectively identified. Patients with insulinomas confirmed by surgery were included, and patients with familial syndromes were excluded. Two radiologists evaluated VPCT images in consensus. Tumour-parenchyma contrast at each time point was measured, and timing of optimal contrast was determined...
January 20, 2017: European Radiology
https://www.readbyqxmd.com/read/28106614/study-of-intrapatient-variability-and-reproducibility-of-quantitative-tumor-perfusion-parameters-evaluated-with-dynamic-contrast-enhanced-ultrasonography
#2
Nathalie Lassau, Bénédicte Coiffier, Laura Faivre, Baya Benatsou, Sophie Bidault, Elizabeth Girard, Bernard Asselain, Stéphanie Pitre-Champagnat, Serge Koscielny
OBJECTIVES: Dynamic contrast-enhanced (DCE) ultrasonography (US) is a functional imaging technique enabling quantitative assessment of solid tumor perfusion in metastatic patients treated with antiangiogenic therapies.The objective of this prospective single-center study was to evaluate in real-life conditions (in routine clinical practice) the intrapatient variability and reproducibility of DCE-US parameters. MATERIALS AND METHODS: Each patient provided written informed consent and had 2 DCE-US examinations (preprandial and postprandial) at baseline, day 15, and 1 month after treatment initiation...
January 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28104801/aquatic-insects-in-a-multistress-environment-cross-tolerance-to-salinity-and-desiccation
#3
Susana Pallarés, María Botella-Cruz, Paula Arribas, Andrés Millán, Josefa Velasco
Exposing organims to a particular stressor may enhance tolerance to a subsequent stress, when protective mechanisms against both stressors are shared. Such cross-tolerance is a common adaptive response in dynamic multivariate environments and often indicates potential co-evolution of stress traits. Many aquatic insects in inland saline waters from Mediterranean-climate regions are sequentially challenged with salinity and desiccation stress. Thus, cross-tolerance to these physiologically similar stressors could have been positively selected in insects of these regions...
January 19, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28104696/systematic-characterization-of-human-testis-specific-actin-capping-protein-%C3%AE-3-as-a-possible-biomarker-for-male-infertility
#4
T Soda, Y Miyagawa, N Ueda, K Takezawa, H Okuda, S Fukuhara, K Fujita, H Kiuchi, M Uemura, Y Okamoto, A Tsujimura, H Tanaka, N Nonomura
STUDY QUESTION: Is actin capping protein (CP) β3 involved in human spermatogenesis and male infertility? SUMMARY ANSWER: Human CPβ3 (hCPβ3) is expressed in testis, changes its localization dynamically during spermatogenesis, and has some association with male infertility. WHAT IS KNOWN ALREADY: The testis-specific α subunit of CP (CPα3) was previously identified in human, and mutations in the cpα3 gene in mouse were shown to induce malformation of the sperm head and male infertility...
January 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28102833/a-multimodal-approach-to-estimating-vigilance-using-eeg-and-forehead-eog
#5
Wei-Long Zheng, Baoliang Lu
OBJECTIVE: Covert aspects of ongoing user mental states provide key context information for user-aware human computer interactions. In this paper, we focus on the problem of estimating the vigilance of users using EEG and EOG signals. APPROACH: The PERCLOS index as vigilance annotation is obtained from eye tracking glasses. To improve the feasibility and wearability of vigilance estimation devices for real-world applications, we adopt a novel electrode placement for forehead EOG and extract various eye movement features, which contain the principal information of traditional EOG...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28100492/dynamic-assembly-of-ultrasoft-colloidal-networks-enables-cell-invasion-within-restrictive-fibrillar-polymers
#6
Alison M Douglas, Alexandros A Fragkopoulos, Michelle K Gaines, L Andrew Lyon, Alberto Fernandez-Nieves, Thomas H Barker
In regenerative medicine, natural protein-based polymers offer enhanced endogenous bioactivity and potential for seamless integration with tissue, yet form weak hydrogels that lack the physical robustness required for surgical manipulation, making them difficult to apply in practice. The use of higher concentrations of protein, exogenous cross-linkers, and blending synthetic polymers has all been applied to form more mechanically robust networks. Each relies on generating a smaller network mesh size, which increases the elastic modulus and robustness, but critically inhibits cell spreading and migration, hampering tissue regeneration...
January 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28099108/integration-of-contrast-enhanced-us-into-a-multimodality-approach-to-imaging-of-nodules-in-a-cirrhotic-liver-how-i-do-it
#7
Patricia C Jo, Hyun-Jung Jang, Peter N Burns, Kelly W Burak, Tae Kyoung Kim, Stephanie R Wilson
Accurate characterization of cirrhotic nodules and early diagnosis of hepatocellular carcinoma (HCC) are of vital importance. Currently, computed tomography (CT) and magnetic resonance (MR) imaging are standard modalities for the investigation of new nodules found at surveillance ultrasonography (US). This article describes the successful integration of contrast material-enhanced US into a multimodality approach for diagnosis of HCC and its benefits in this population. The application of contrast-enhanced US immediately following surveillance US allows for prompt dynamic contrast-enhanced evaluation, removing the need for further imaging of benign lesions...
February 2017: Radiology
https://www.readbyqxmd.com/read/28099013/dynamic-nuclear-polarization-signal-enhancement-with-high-affinity-biradical-tags
#8
Rivkah Tamar Rogawski, Ivan V Sergeyev, Yongjun Li, Maria Francesca Ottaviani, Virginia W Cornish, Ann E McDermott
Dynamic nuclear polarization is an emerging technique for sensitizing solid state NMR experiments by transferring polarization from electrons to nuclei. Stable biradicals, the polarization source for the cross effect mechanism, are typically co-dissolved at millimolar concentrations with proteins of interest. Here we describe the high-affinity biradical tag TMP-T, created by covalently linking trimethoprim, a nanomolar affinity ligand of dihydrofolate reductase (DHFR), to the biradical polarizing agent TOTAPOL...
January 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28094488/effects-of-leg-contrast-strength-training-on-sprint-agility-and-repeated-change-of-direction-performance-in-male-soccer-players
#9
Mehréz Hammami, Yassine Negra, Roy J Shephard, Mohamed Souhaiel Chelly
BACKGROUND: Contrast training is popular technique among individuals who are involved in dynamic sports, having as its goal an increase in dynamic muscular performance. It is characterized by the use of high and low loads in the same strength training session. The present investigation aimed to determine the effects of adding 8--weeks of contrast strength training (CSTP) to regular soccer practice in U--17 male soccer players during the competitive season. We hypothesized that CSTP would enhance their performance...
January 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28093473/differential-regulation-of-nmda-receptor-mediated-transmission-by-sk-channels-underlies-dorsal-ventral-differences-in-dynamics-of-schaffer-collateral-synaptic-function
#10
Walter E Babiec, Shekib A Jami, Ryan Guglietta, Patrick B Chen, Thomas J O'Dell
: Behavioral, physiological, and anatomical evidence indicates that the dorsal and ventral zones of the hippocampus have distinct roles in cognition. How the unique functions of these zones might depend on differences in synaptic and neuronal function arising from the strikingly different gene expression profiles exhibited by dorsal and ventral CA1 pyramidal cells is unclear. To begin to address this question, we investigated the mechanisms underlying differences in synaptic transmission and plasticity at dorsal and ventral Schaffer collateral (SC) synapses in the mouse hippocampus...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28092496/the-effect-of-contrast-material-on-radiation-dose-at-ct-part-i-incorporation-of-contrast-material-dynamics-in-anthropomorphic-phantoms
#11
Pooyan Sahbaee, W Paul Segars, Daniele Marin, Rendon C Nelson, Ehsan Samei
Purpose To develop a method to incorporate the propagation of contrast material into computational anthropomorphic phantoms for estimation of organ dose at computed tomography (CT). Materials and Methods A patient-specific physiologically based pharmacokinetic (PBPK) model of the human cardiovascular system was incorporated into 58 extended cardiac-torso (XCAT) patient phantoms. The PBPK model comprised compartmental models of vessels and organs unique to each XCAT model. For typical injection protocols, the dynamics of the contrast material in the body were described according to a series of patient-specific iodine mass-balance differential equations, the solutions to which provided the contrast material concentration time curves for each compartment...
January 13, 2017: Radiology
https://www.readbyqxmd.com/read/28092414/dce-mri-of-the-prostate-using-shutter-speed-vs-tofts-model-for-tumor-characterization-and-assessment-of-aggressiveness
#12
Stefanie J Hectors, Cecilia Besa, Mathilde Wagner, Guido H Jajamovich, George K Haines, Sara Lewis, Ashutosh Tewari, Ardeshir Rastinehad, Wei Huang, Bachir Taouli
PURPOSE: To quantify Tofts model (TM) and shutter-speed model (SSM) perfusion parameters in prostate cancer (PCa) and noncancerous peripheral zone (PZ) and to compare the diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to Prostate Imaging and Reporting and Data System (PI-RADS) classification for the assessment of PCa aggressiveness. MATERIALS AND METHODS: Fifty PCa patients (mean age 60 years old) who underwent MRI at 3...
January 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28091539/an-electromagnetic-modulator-based-on-electrically-controllable-metamaterial-analogue-to-electromagnetically-induced-transparency
#13
Yuancheng Fan, Tong Qiao, Fuli Zhang, Quanhong Fu, Jiajia Dong, Botao Kong, Hongqiang Li
Electromagnetically induced transparency (EIT) is a promising technology for the enhancement of light-matter interactions, and recent demonstrations of the EIT analogue realized in artificial micro-structured medium have remarkably reduced the extreme requirement for experimental observation of EIT spectrum. In this paper, we propose to electrically control the EIT-like spectrum in a metamaterial as an electromagnetic modulator. A diode acting as a tunable resistor is loaded in the gap of paired wires to inductively tune the magnetic resonance, which induces remarkable modulation on the EIT-like spectrum through the metamaterial sample...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090589/spiral-perfusion-imaging-with-consecutive-echoes-spice%C3%A2-for-the-simultaneous-mapping-of-dsc-and-dce-mri-parameters-in-brain-tumor-patients-theory-and-initial-feasibility
#14
Eric S Paulson, Douglas E Prah, Kathleen M Schmainda
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhibits combined T1, T2, and T2* shortening effects in tissue, and therefore, the results of both DCE- and DSC-MRI can be confounded by these opposing effects...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28088373/dynamic-contrast-enhanced-magnetic-resonance-imaging-dce-mri-for-the-prediction-of-non-union-consolidation
#15
Christian Fischer, Mareike Nissen, Gerhard Schmidmaier, Thomas Bruckner, Hans-Ulrich Kauczor, Marc-André Weber
INTRODUCTION: Non-union perfusion can be visualized with dynamic contrast-enhanced (DCE) MRI. This study evaluated DCE-MRI to predict non-union consolidation after surgery and detect factors that affect bone healing. MATERIALS AND METHODS: Between 2010 and 2015 non-union perfusion was prospectively quantified in 205 patients (mean age, 51.5 years, 129 men, 76 women) before intervention and at 6, 12, 26, 52 and more weeks follow-up. DCE-MRI results were related to the osseous consolidation, the ability to predict successful outcome was estimated by ROC analysis...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28088245/the-value-of-dynamic-contrast-enhanced-mri-in-characterizing-complex-ovarian-tumors
#16
Hai-Ming Li, Jin-Wei Qiang, Feng-Hua Ma, Shu-Hui Zhao
BACKGROUND: The study aimed to investigate the utility of dynamic contrast enhanced MRI (DCE-MRI) in the differentiation of malignant, borderline, and benign complex ovarian tumors. METHODS: DCE-MRI data of 102 consecutive complex ovarian tumors (benign 15, borderline 16, and malignant 71), confirmed by surgery and histopathology, were analyzed retrospectively. The patterns (I, II, and III) of time-signal intensity curve (TIC) and three semi-quantitative parameters, including enhancement amplitude (EA), maximal slope (MS), and time of half rising (THR), were evaluated and compared among benign, borderline, and malignant ovarian tumors...
January 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28081106/broad-bandwidth-reversible-and-high-contrast-ratio-optical-diode
#17
Chao Li, Min Wang, Jun-Fang Wu
Fano resonance is widely used to realize high-contrast nonreciprocal transmission. However, resonance-enhanced all-optical diodes (AOD) are bandwidth-limited, and their transmission rates are normally low, which restricts realistic application. In this Letter, we analytically and numerically demonstrate that this limitation can be overcome once multistability of cascaded nonlinear cavities is appropriately excited. By precisely molding the transiting of the signal light between multistable states, a high-contrast-ratio, high-unidirectional-transmission-rate, and reversal-controllable AOD is achieved with a bandwidth over 2...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28079383/structure-and-interaction-in-ph-dependent-phase-behavior-of-nanoparticle-protein-systems
#18
Indresh Yadav, Sugam Kumar, Vinod K Aswal, Joachim Kohlbrecher
The pH-dependent structure and interaction of anionic silica nanoparticles (diameter 18 nm) with two globular model proteins-lysozyme and bovine serum albumin (BSA) have been studied. Cationic lysozyme adsorbs strongly on the nanoparticles and the adsorption follows an exponential growth as a function of lysozyme concentration, where the saturation value increases with pH approaching towards the isoelectric point (IEP) of lysozyme. In contrast, irrespective of the pH, anionic BSA does not show any adsorption...
January 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28078795/a-continuous-infusion-dynamic-mri-model-at-3-0-tesla-for-the-serial-quantitative-evaluation-of-microvascular-proliferation-in-an-animal-model-of-glioblastoma-multiforme
#19
Hunter R Underhill
PURPOSE: To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme. METHODS: The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, K(trans) ; intravascular plasma fraction, vp ) cannot be individually separated and solves for a single parameter (k(vasc) ) that quantifies the T1 -weighted contrast enhancement from dynamic images acquired during continuous contrast agent (CA) infusion...
January 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28078511/intra-individual-comparison-of-different-gadolinium-based-contrast-agents-in-the-quantitative-evaluation-of-c6-glioma-with-dynamic-contrast-enhanced-magnetic-resonance-imaging
#20
Ying Li, Gang Liu, Xin Lou, Zhiye Chen, Lin Ma
This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0...
January 4, 2017: Science China. Life Sciences
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