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https://www.readbyqxmd.com/read/27905865/transient-bone-marrow-edema-syndrome-versus-osteonecrosis-perfusion-patterns-at-dynamic-contrast-enhanced-mr-imaging-with-high-temporal-resolution-can-allow-differentiation
#1
Tobias Geith, Thomas Niethammer, Stefan Milz, Olaf Dietrich, Maximilian Reiser, Andrea Baur-Melnyk
Purpose To prospectively evaluate the perfusion patterns at quantitative dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging of transient bone marrow edema syndrome (TBMES) and avascular osteonecrosis. Materials and Methods Institutional review board approval and written informed consent were obtained. Thirty-two patients (21 men, 11 women; mean age, 48 years; 26 hips, 10 knees) underwent conventional MR imaging and a dynamic contrast-enhanced three-dimensional spoiled gradient-echo sequence at 3 T...
December 1, 2016: Radiology
https://www.readbyqxmd.com/read/27904441/dynamic-contrast-enhanced-ultrasound-of-the-bowel-wall-with-quantitative-assessment-of-crohn-s-disease-activity-in-childhood
#2
Damjana Kljucevsek, Dubravka Vidmar, Darja Urlep, Rok Dezman
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has become an established non-invasive, patient-friendly imaging technique which improves the characterization of lesions. In addition, dynamic contrast-enhanced ultrasound (DCE-US) provides valuable information concerning perfusion of examined organs. This review addresses current applications of CEUS in children, focused on DCE-US of the bowel wall in patients with Crohn disease, which enables realtime assessment of the bowel wall vascularity with semi-quantitative and quantitative assessment of disease activity and response to medical treatment...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27903431/differential-regulation-of-baicalin-and-scutellarin-on-ampk-and-akt-in-promoting-adipose-cell-glucose-disposal
#3
Le-Le Yang, Na Xiao, Jinfeng Liu, Kang Liu, Baolin Liu, Ping Li, Lian-Wen Qi
Baicalin and scutellarin, two flavonoid glucuronic acids isolated from Scutellaria baicalensis, exhibit beneficial effects on glucose homeostasis. Baicalin and scutellarin are similar in structure except scutellarin has an additional hydroxyl at composition C-4'. In this work, we observed that baicalin and scutellarin promoted glucose disposal in mice and in adipocytes. Baicalin selectively increased phosphorylation of AMP-activated kinase (AMPK), while scutellarin selectively enhanced Akt phosphorylation. Both of them increased AS160 phosphorylation and glucose uptake in basal condition...
November 26, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27902858/reliable-estimation-of-microvascular-flow-patterns-in-patients-with-disrupted-blood-brain-barrier-using-dynamic-susceptibility-contrast-mri
#4
Mikkel Bo Hansen, Anna Tietze, Jayashree Kalpathy-Cramer, Elizabeth R Gerstner, Tracy T Batchelor, Leif Østergaard, Kim Mouridsen
PURPOSE: To present and quantify the performance of a method to compute tissue hemodynamic parameters from dynamic susceptibility contrast (DSC) MRI data in brain tissue with possible nonintact blood-brain barrier. THEORY AND MATERIALS AND METHODS: We propose a Bayesian scheme to obtain perfusion metrics, including capillary transit-time heterogeneity (CTH), from DSC-MRI data in the presence of contrast agent extravasation. Initial performance assessment is performed through simulations...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27902592/dynamic-contrast-enhanced-breast-magnetic-resonance-imaging-for-the-prediction-of-early-and-late-recurrences-in-breast-cancer
#5
Eun Jung Choi, HyeMi Choi, Sin Ae Choi, Ji Hyun Youk
The aim of the study was to evaluate dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI) features for the prediction of early and late recurrences in patients with breast cancer.Of 1030 breast cancer patients who underwent surgery at our hospital from January 2007 to July 2011, 83 recurrent breast cancer patients were enrolled in this study. We compared MRI features (background parenchymal enhancement [BPE], internal enhancement, adjacent vessel sign, whole-breast vascularity, initial enhancement pattern, kinetic curve types, and quantitative kinetic parameters) and clinico-pathologic variables (age, stage, histologic grade, nuclear grade, existence of lymphovascular invasion and extensive intraductal carcinoma component, and immunohistochemical profiles) between patients with early (≤2...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27898602/novel-high-spatiotemporal-resolution-versus-standard-of-care-dynamic-contrast-enhanced-breast-mri-comparison-of-image-quality
#6
Courtney K Morrison, Leah C Henze Bancroft, Wendy B DeMartini, James H Holmes, Kang Wang, Ryan J Bosca, Frank R Korosec, Roberta M Strigel
OBJECTIVE: Currently, dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) prioritizes spatial resolution over temporal resolution given the limitations of acquisition techniques. The purpose of our intrapatient study was to assess the ability of a novel high spatial and high temporal resolution DCE breast MRI method to maintain image quality compared with the clinical standard-of-care (SOC) MRI. MATERIALS AND METHODS: Thirty patients, each demonstrating a focal area of enhancement (29 benign, 1 cancer) on their SOC MRI, consented to undergo a research DCE breast MRI on a second date...
November 28, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27896498/ratchet-effect-for-two-dimensional-nanoparticle-motion-in-a-corrugated-oscillating-channel
#7
Matthias Radtke, Roland R Netz
The motion of a single rigid or elastic particle inside a corrugated narrow channel is investigated by means of Brownian dynamics simulations. Periodic oscillations of one of the asymmetric channel surfaces induce directed particle transport. For different surface structures of the resting channel surface, we determine optimal transport properties in terms of the driving frequency, particle size, and corrugation amplitude. The transport direction is changed when switching from perpendicular motion of the oscillating surface to parallel motion with respect to the resting surface, which can be rationalized by a transition from a flashing to a pushing ratchet effect...
November 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27895875/takeaways-from-pre-contrast-t1-and-t2-breast-magnetic-resonance-imaging-in-women-with-recently-diagnosed-breast-cancer
#8
Seung Hee Han, Yeong Yi An, Bong Joo Kang, Sung Hun Kim, Eun Jae Lee
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE - MRI) has been widely used in the management of breast cancer, and its diagnostic value in breast imaging has been demonstrated. There have only been a few reports regarding the usefulness of pre-contrast imaging. Knowledge about clinically significant findings of preoperative, pre-contrast T1 and T2 MR images will allow more accurate decisions regarding patient treatment and management. OBJECTIVES: The aim of this study was to evaluate the clinically significant findings of preoperative, pre-contrast T1 and T2 MR images in recently diagnosed breast cancer patients...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27891543/dynamic-neighbouring-participation-of-nitrogen-lone-pairs-on-the-chromogenic-behaviour-of-trans-bis-salicylaldiminato-pt-ii-coordination-platforms
#9
Takumi Hashimoto, Kanako Fukumoto, Ngoc Ha-Thu Le, Tatsuya Matsuoka, Soichiro Kawamorita, Naruyoshi Komiya, Takeshi Naota
The participation of neighbouring nitrogen lone pairs in the chromogenic control of trans-bis(salicylaldiminato)Pt(ii) platforms was examined, using newly designed Pt analogues bearing salicylaldehyde hydrazone ligands. A series of non-vaulted and vaulted Pt complexes (1-5) with salicylaldehyde hydrazones as trans-coordinated bidentate ligands were synthesized and characterized with regard to the chromogenic behaviour of the trans-bis(salicylaldiminato)Pt(ii) coordination platforms. X-ray diffraction and 2D NMR data demonstrated that, in the case of the non-vaulted N-monomethyl complexes 1, there was significant participation of neighbouring N(2) lone pairs in the d-π conjugation of the trans-bis(salicylaldiminato)Pt(ii) platforms owing to conformational fixation arising from intramolecular hydrogen bonding...
November 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27888709/correlations-between-dce-mri-and-histopathological-parameters-in-head-and-neck-squamous-cell-carcinoma
#10
Alexey Surov, Hans Jonas Meyer, Matthias Gawlitza, Anne-Kathrin Höhn, Andreas Boehm, Thomas Kahn, Patrick Stumpp
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) can characterize perfusion and vascularization of tissues. DCE MRI parameters can differentiate between malignant and benign lesions and predict tumor grading. The purpose of this study was to correlate DCE MRI findings and various histopathological parameters in head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Sixteen patients with histologically proven HNSCC (11 cases primary tumors and in 5 patients with local tumor recurrence) were included in the study...
November 23, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27888545/anti-angiogenic-therapy-affects-the-relationship-between-tumor-vascular-structure-and-function-a-correlation-study-between-micro-computed-tomography-angiography-and-dynamic-contrast-enhanced-mri
#11
Eugene Kim, Jana Kim, Gunhild Mari Maelandsmo, Berit Johansen, Siver Andreas Moestue
PURPOSE: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. METHODS: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n = 9), AVX235-treated (n = 9), and control (n = 8). DCE-MRI was performed pre- and post-treatment...
November 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27884018/blood-transfusion-during-radical-chemo-radiotherapy-does-not-reduce-tumour-hypoxia-in-squamous-cell-cancer-of-the-head-and-neck
#12
Liam Welsh, Rafal Panek, Angela Riddell, Kee Wong, Martin O Leach, Mahvash Tavassoli, Durdana Rahman, Maria Schmidt, Tara Hurley, Lorna Grove, Thomas Richards, Dow-Mu Koh, Christopher Nutting, Kevin Harrington, Kate Newbold, Shreerang Bhide
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) undergoing radical chemo-radiation (CRT) frequently receive transfusion with packed red cells (PRCT) during radiotherapy on the basis that PRCT increases tumour oxygenation and overcomes hypoxia-induced radio-resistance. This is likely to be a significant oversimplification given the fact that tumour hypoxia is the result of several intrinsic and extrinsic factors, including many that are not directly related to serum haemoglobin (Hb)...
November 24, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27883923/gilles-de-la-tourette-syndrome-is-associated-with-hypermethylation-of-the-dopamine-d2-receptor-gene
#13
Kirsten R Müller-Vahl, Gesa Loeber, Alexandra Kotsiari, Linda Müller-Engling, Helge Frieling
Several lines of evidence support a "dopaminergic hypothesis" in the pathophysiology of Gilles de la Tourette syndrome (TS). The aim of this study was to investigate for the first time epigenetic changes in DNA methylation in different dopamine genes in adult patients with TS. We included 51 well characterized adult patients with TS (41 males, 10 females, mean age = 35 ± 12.6 years, range, 18-71 years) and compared results with data from a group of 51 sex- and age-matched healthy controls. Bisulfite sequencing was used to measure peripheral DNA methylation of the dopamine transporter (DAT), the dopamine D2 receptor (DRD2), and the catechol-O-methyltransferase (COMT) genes...
November 12, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27881959/effective-connectivity-within-the-mesocorticolimbic-system-during-resting-state-in-cocaine-users
#14
Suchismita Ray, Xin Di, Bharat B Biswal
Objective: Although effective connectivity between brain regions has been examined in cocaine users during tasks, no effective connectivity study has been conducted on cocaine users during resting-state. In the present functional magnetic resonance imaging study, we examined effective connectivity in resting-brain, between the brain regions within the mesocorticolimbic dopamine system, implicated in reward and motivated behavior, while the chronic cocaine users and controls took part in a resting-state scan by using a spectral Dynamic causal modeling (spDCM) approach...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27881800/genetic-stability-of-physiological-responses-to-defoliation-in-a-eucalypt-and-altered-chemical-defence-in-regrowth-foliage
#15
Christina L Borzak, Brad M Potts, Karen M Barry, Elizabeth A Pinkard, Julianne M O'Reilly-Wapstra
Defoliation may initiate physiological recovery and chemical defence mechanisms that allow a plant to improve fitness after damage. Such responses may result in changes in plant resource allocation that influence growth and foliar chemistry. In this study, we investigated the nature and stability of the defoliation response of juvenile plants from three divergent populations of Eucalyptus globulus Labill. A partial defoliation treatment that removed all upper crown leaves and the apical buds was applied to plants sourced from eight families from each of three populations representing contrasting chemical resistance to mammalian herbivory...
November 22, 2016: Tree Physiology
https://www.readbyqxmd.com/read/27881643/inclusion-body-fusion-of-human-parainfluenza-virus-type-3-regulated-by-acetylated-%C3%AE-tubulin-enhances-viral-replication
#16
Shengwei Zhang, Yanliang Jiang, Qi Cheng, Zhong Yi, Yali Qin, Mingzhou Chen
: Viral inclusion bodies (IBs) or replication factories are unique structures generated by viral proteins together with some cellular proteins as a platform for efficient viral replication, but little is known about the mechanism underlying IB formation and fusion. Our previous study demonstrated that the interaction between the nucleoprotein (N) and phosphoprotein (P) of human parainfluenza virus type 3 (HPIV3), an enveloped virus of great medical impact, can form IBs. In this study, we found that small IBs can fuse with each other to form large IBs that enhance viral replication...
November 23, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27881172/eigenspace-based-beamformer-using-oblique-signal-subspace-projection-for-ultrasound-plane-wave-imaging
#17
Saeid Aliabadi, Yuanyuan Wang, Jinhua Yu, Jinxin Zhao, Wei Guo, Shun Zhang
BACKGROUND: The Eigenspace-based beamformers, by orthogonal projection of signal subspace, can remove a large part of the noise, and provide better imaging contrast upon the minimum variance beamformer. However, wrong estimate of signal and noise component may bring dark-spot artifacts and distort the signal intensity. The signal component and noise and interference components are considered uncorrelated in conventional eigenspace-based beamforming methods. In ultrasound imaging, however, signal and noise are highly correlated...
November 24, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27880868/origin-and-evolution-of-the-metazoan-non-coding-regulatory-genome
#18
REVIEW
Federico Gaiti, Andrew D Calcino, Miloš Tanurdžić, Bernard M Degnan
Animals rely on genomic regulatory systems to direct the dynamic spatiotemporal and cell-type specific gene expression that is essential for the development and maintenance of a multicellular lifestyle. Although it is widely appreciated that these systems ultimately evolved from genomic regulatory mechanisms present in single-celled stem metazoans, it remains unclear how this occurred. Here, we focus on the contribution of the non-coding portion of the genome to the evolution of animal gene regulation, specifically on recent insights from non-bilaterian metazoan lineages, and unicellular and colonial holozoan sister taxa...
November 20, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27876537/artificial-neural-networks-approach-to-pharmacokinetic-model-selection-in-dce-mri-studies
#19
Mohammad-Reza Mohammadian-Behbahani, Ali-Reza Kamali-Asl
PURPOSE: In pharmacokinetic analysis of Dynamic Contrast Enhanced MRI data, a descriptive physiological model should be selected properly out of a set of candidate models. Classical techniques suggested for this purpose suffer from issues like computation time and general fitting problems. This article proposes an approach based on Artificial Neural Networks (ANNs) for solving these problems. METHODS: A set of three physiologically and mathematically nested models generated from the Tofts model were assumed: Model I, II and III...
November 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27875218/entropy-of-ultrasound-contrast-agent-velocity-fields-for-angiogenesis-imaging-in-prostate-cancer
#20
Ruud van Sloun, Libertario Demi, Arnoud Postema, Jean de la Rosette, Hessel Wijkstra, Massimo Mischi
Prostate cancer care can benefit from accurate and cost-efficient imaging modalities that are able to reveal prognostic indicators for cancer. Angiogenesis is known to play a central role in the growth of tumors towards a metastatic or a lethal phenotype.With the aim of localizing angiogenic activity in a noninvasive manner, Dynamic Contrast Enhanced Ultrasound (DCEUS) has been widely used. Usually, the passage of ultrasound contrast agents thought the organ of interest is analyzed for the assessment of tissue perfusion...
November 16, 2016: IEEE Transactions on Medical Imaging
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