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https://www.readbyqxmd.com/read/28431804/prognostic-value-of-dynamic-mri-positive-enhancement-integral-color-mapping-in-osteosynthesis-of-undisplaced-femoral-neck-fractures
#1
Masatoshi Morimoto, Yoshinori Takahashi, Takahiro Kubo, Kosuke Sugiura, Yasuaki Tamaki, Shunichi Toki, Katsuyoshi Suganuma, Kazumasa Inoue, Keisuke Adachi, Takashi Chikawa, Koichi Sairyo, Akihiro Nagamachi
AIMS: The common treatment for an undisplaced femoral neck fracture is osteosynthesis. Two major complications of osteosynthesis are non-union and late collapse of the femoral head. We speculated that femoral head perfusion is one of the most important factors that affect the outcome of osteosynthesis after femoral neck fracture. We have preoperatively estimated femoral head perfusion by dynamic MRI positive enhancement integral color mapping (PEICM). The purpose of this study was to evaluate the outcomes of undisplaced femoral neck fractures based on PEICM...
April 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28430860/increased-brainstem-perfusion-but-no-blood-brain-barrier-disruption-during-attacks-of-migraine-with-aura
#2
Anders Hougaard, Faisal M Amin, Casper E Christensen, Samaira Younis, Frauke Wolfram, Stig P Cramer, Henrik B W Larsson, Messoud Ashina
The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28429346/dynamic-and-contrast-enhanced-ct-imaging-of-lung-carcinoma-pulmonary-tuberculoma-and-inflammatory-pseudotumor
#3
C-R Li, Y-Z Li, Y-M Li, Y-S Zheng
OBJECTIVE: Our main aim was to investigate the effect of dynamic and contrast enhanced CT imaging on differential diagnosis of lung carcinoma, pulmonary tuberculoma, inflammatory pseudotumor, and coexisting pulmonary tuberculosis and lung cancer. PATIENTS AND METHODS: About, 144 patients with pulmonary sarcoidosis as the study subjects were chosen which included: 36 patients with lung carcinoma, 36 patients with pulmonary tuberculoma, 36 patients with inflammatory pseudotumor, 36 patients with coexisting pulmonary tuberculosis and lung cancer...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28428469/verification-of-the-injection-pressure-reduction-effect-using-the-novel-indwelling-needle-for-contrast-enhanced-ct
#4
Daiki Watanabe, Masaaki Fukunaga, Hiroyuki Yamamoto
PURPOSE: The purpose of this study was to investigate the injection pressure reduction effect of the novel indwelling needle (Becton, Dickinson and Company). METHOD: We evaluated the period of 651 patients who underwent dynamic computed tomography. We compared the maximum injection pressure. The contrast medium was administered at 320, 350, and 370 mgI/ml. RESULT: The maximum injection pressure of the novel indwelling needle in 22 G was decreased 10% compared with SC5 in all contrast media...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28427629/development-of-a-novel-folate-modified-nanobubbles-with-improved-targeting-ability-to-tumor-cells
#5
Sujuan Duan, Lu Guo, Dandan Shi, Mengmeng Shang, Dong Meng, Jie Li
Conjugation of folate (FOL) to nanobubbles could enhance the selective targeting to tumors expressing high levels of folate receptor (FR). To further improve the selective targeting ability of FOL-modified nanobubbles, a novel FOL-targeted nanobubble ((FOL)2-NB) with increasing FOL content (accomplished by linking two FOL molecules per DSPE-PEG2000 chain) was synthesized, through the methods of mechanical shaking and low-speed centrifugation based on lipid-stabilized perfluoropropane. The bubble size and distribution range were measured by dynamic light scattering (DLS)...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427220/multiparametric-imaging-using-18f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#6
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment 18F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from 18F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427122/-application-on-the-quantitative-perfusion-parameters-of-dynamic-contrast-enhanced-mri-in-the-pathological-subtype-of-uterine-leiomyoma
#7
J Zheng, Z H Zhao, J F Yang, L Zhao, L M Yang, H J Hu
Objective: To analyze the value of the quantitative perfusion parameters of dynamic contrast-enhanced MRI(DCE-MRI) in the pathological subtype of uterine leiomyoma. Methods: A total of 35 cases of uterine leiomyoma confirmed by surgery and pathology were retrospectively analyzed in Shaoxing People's Hospital from October 2015 to May 2016.All cases underwent DCE-MRI. Quantitative perfusion parameters were prospectively measured and analyzed, including transfer constant (K(trans)) , efflux rate constant (K(ep)), extravascular extracellular space volume ratio (V(e)), blood plasma volume ratio (V(p)), permeability surface area product (PS) and plasma flow (F(p)) , using signal-input two-compartment tracer kinetic models (Extended Tofts model and Exchange model) in 35 leiomyoma cases...
April 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28425758/agreement-between-mri-and-pathologic-analyses-for-determination-of-tumor-size-and-correlation-with-immunohistochemical-factors-of-invasive-breast-carcinoma
#8
Eun Young Yoo, Sang Yu Nam, Hye-Young Choi, Min Ji Hong
Background There may be discordance between tumor size determined by magnetic resonance imaging (MRI) and that observed during pathologic analyses. Purpose To evaluate MRI-pathology concordance of tumor size in patients with invasive breast carcinoma. Material and Methods Data from 307 invasive breast carcinomas were analyzed retrospectively. Preoperative breast MRI was reviewed for size, lesion type, morphology, and dynamic contrast-enhanced tumor kinetics. MRI tumor size was compared with tumor size measurements from the pathologic analysis...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28425493/characterization-of-different-microbubbles-in-assisting-focused-ultrasound-induced-blood-brain-barrier-opening
#9
Sheng-Kai Wu, Po-Chun Chu, Wen-Yen Chai, Shih-Tsung Kang, Chih-Hung Tsai, Ching-Hsiang Fan, Chih-Kuang Yeh, Hao-Li Liu
Microbubbles (MBs) serve as a critical catalyst to amplify local cavitation in CNS capillary lumen to facilitate focused ultrasound (FUS) to transiently open the blood-brain barrier (BBB). However, limited understanding is available regarding the effect of different microbubbles to induce BBB opening. The aim of this study is to characterize different MBs on their effect in FUS-induced BBB opening. Three MBs, SonoVue, Definity, and USphere, were tested, with 0.4-MHz FUS exposure at 0.62-1.38 of mechanical index (MI) on rats...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425048/biopsy-targeting-with-dynamic-contrast-enhanced-versus-standard-neuronavigation-mri-in-glioma-a-prospective-double-blinded-evaluation-of-selection-benefits
#10
Vera C Keil, Bogdan Pintea, Gerrit H Gielen, Susanne Greschus, Rolf Fimmers, Jürgen Gieseke, Matthias Simon, Hans H Schild, Dariusch R Hadizadeh
Current biopsy planning based on contrast-enhanced T1W (CET1W) or FLAIR sequences frequently delivers biopsy samples that are not in concordance with the gross tumor diagnosis. This study investigates whether the quantitative information of transfer constant K(trans) maps derived from T1W dynamic contrast-enhanced MRI (DCE-MRI) can help enhance the quality of biopsy target selection in glioma. 28 patients with suspected glioma received MRI including DCE-MRI and a standard neuronavigation protocol of 3D FLAIR- and CET1W data sets (0...
April 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28424683/novel-strategy-to-expand-super-charged-nk-cells-with-significant-potential-to-lyse-and-differentiate-cancer-stem-cells-differences-in-nk-expansion-and-function-between-healthy-and-cancer-patients
#11
Kawaljit Kaur, Jessica Cook, So-Hyun Park, Paytsar Topchyan, Anna Kozlowska, Nick Ohanian, Changge Fang, Ichiro Nishimura, Anahid Jewett
Natural killer (NK) cells are known to target cancer stem cells and undifferentiated tumors. In this paper, we provide a novel strategy for expanding large numbers of super-charged NK cells with significant potential to lyse and differentiate cancer stem cells and demonstrate the differences in the dynamics of NK cell expansion between healthy donors and cancer patients. Decline in cytotoxicity and lower interferon (IFN)-γ secretion by osteoclast (OC)-expanded NK cells from cancer patients correlates with faster expansion of residual contaminating T cells within purified NK cells, whereas healthy donors' OCs continue expanding super-charged NK cells while limiting T cell expansion for up to 60 days...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28423951/preparation-characterization-and-dynamical-mechanical-properties-of-dextran-coated-iron-oxide-nanoparticles-dionps
#12
Hatice Kaplan Can, Serap Kavlak, Shahed ParviziKhosroshahi, Ali Güner
Dextran-coated iron oxide nanoparticles (DIONPs) with appropriate surface chemistry exhibit many interesting properties that can be exploited in a variety of biomedical applications such as magnetic resonance imaging (MRI) contrast enhancement, tissue repair, hyperthermia, drug delivery and in cell separation. This paper reports the experimental detail for preparation, characterization and investigation of thermal and dynamical mechanical characteristics of the dextran-coated Fe3O4 magnetic nanoparticles. In our work, DIONPs were prepared in a 1:2 ratio of Fe(II) and Fe(III) salt in the HCl solution with NaOH at given temperature...
April 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28423950/hepatoprotective-and-free-radical-scavenging-actions-of-quercetin-nanoparticles-on-a%C3%AF-atoxin-b1-induced-liver-damage-in-vitro-in-vivo-studies
#13
Aziz Eftekhari, Elham Ahmadian, Vahid Panahi-Azar, Hedayat Hosseini, Mahnaz Tabibiazar, Solmaz Maleki Dizaj
The objective of present study was in vitro and in vivo evaluation of hepatoprotective and antioxidant activity of Quercetin nanoparticles (Q NPs) against toxicity induced by aflatoxin B1. The Q NPs were prepared using precipitation method. Hepatocytes were prepared by the method of collagenase enzyme perfusion via portal vein. The NPs were characterized in terms of size and morphology using dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. The level of parameters, such as cell death, ROS formation, lipid peroxidation, mitochondrial membrane potential and cellular glutathione (GSH) content, in the aflatoxin B1-treated and non-treated hepatocytes were determined and the mentioned markers were assessed in the presence of Q NPs...
April 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28423412/brief-presentation-enhances-various-simultaneous-contrast-effects
#14
Sae Kaneko, Stuart Anstis, Ichiro Kuriki
Kaneko and Murakami (2012) demonstrated that simultaneous contrast for brightness and color (chromatic saturation) were enhanced by flashing the stimulus very briefly (10 ms). Here we examined whether this effect of duration generalized to other visual features. Tilt illusion and simultaneous hue contrast were both shown to be much stronger with a stimulus duration of 10 ms compared with 500 ms. The similar temporal dynamics for simultaneous contrast across visual features suggest common underlying principles...
April 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28418670/polarization-effects-on-the-cellulose-dissolution-in-ionic-liquids-molecular-dynamics-simulations-with-polarization-model-and-integrated-tempering-enhanced-sampling-method
#15
Zigui Kan, Qiang Zhu, Lijiang Yang, Zhixiong Huang, Biao-Bing Jin, Jing Ma
Conformation of cellulose with various degree of polymerization of n = 1~12 in ionic liquid 1,3-dimethylimidazolium chloride ([C1mim]Cl) and the intermolecular interaction between them were studied by means of molecular dynamics (MD) simulations with fixed-charge and charge variable polarizable force fields, respectively. The integrated tempering enhanced sampling method was also employed in the simulations in order to improve the sampling efficiency. Cellulose undergoes significant conformational changes from a gaseous right-hand helical twist along the long axis to a flexible conformation in ionic liquid...
April 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28415647/contrast-agents-in-dynamic-contrast-enhanced-magnetic-resonance-imaging
#16
REVIEW
Yuling Yan, Xilin Sun, Baozhong Shen
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive method to assess angiogenesis, which is widely used in clinical applications including diagnosis, monitoring therapy response and prognosis estimation in cancer patients. Contrast agents play a crucial role in DCE-MRI and should be carefully selected in order to improve accuracy in DCE-MRI examination. Over the past decades, there was much progress in the development of optimal contrast agents in DCE-MRI. In this review, we describe the recent research advances in this field and discuss properties of contrast agents, as well as their advantages and disadvantages...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415581/tumor-physiological-changes-during-hypofractionated-stereotactic-body-radiation-therapy-assessed-using-multi-parametric-magnetic-resonance-imaging
#17
Heling Zhou, Zhang Zhang, Rebecca Denney, Jessica S Williams, Jeni Gerberich, Strahinja Stojadinovic, Debabrata Saha, John M Shelton, Ralph P Mason
Radiation therapy is a primary treatment for non-resectable lung cancer and hypoxia is thought to influence tumor response. Hypoxia is expected to be particularly relevant to the evolving new radiation treatment scheme of hypofractionated stereotactic body radiation therapy (SBRT). As such, we sought to develop non-invasive tools to assess tumor pathophysiology and response to irradiation. We applied blood oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) MRI, together with dynamic contrast enhanced (DCE) MRI to explore the longitudinal effects of SBRT on tumor oxygenation and vascular perfusion using A549 human lung cancer xenografts in a subcutaneous rat model...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411271/neural-correlates-of-semantic-prediction-and-resolution-in-sentence-processing
#18
Luigi Grisoni, Tally McCormick Miller, Friedemann Pulvermüller
Most brain imaging studies of language comprehension focus on activity following upon meaningful stimuli. Testing adult human participants with high-density EEG, we show that, already before the presentation of a critical word, context-induced semantic predictions are reflected by a neurophysiological index, which we therefore call the Semantic Readiness Potential (SRP). The SRP precedes critical words if previous sentence context constrains the upcoming semantic content (High-constraint contexts), but not in unpredictable (Low-constraint) contexts...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28411270/short-term-facilitation-at-a-detonator-synapse-requires-the-distinct-contribution-of-multiple-types-of-voltage-gated-calcium-channels
#19
Simon Chamberland, Alesya Evstratova, Katalin Tóth
Neuronal calcium elevations are shaped by several key parameters, including the properties, density, and the spatial location of voltage-gated calcium channels (VGCCs). These features allow presynaptic terminals to translate complex firing frequencies and tune the amount of neurotransmitter released. While synchronous neurotransmitter release relies on both P/Q- and N-type VGCCs at hippocampal MF-CA3 synapses, the specific contribution of VGCCs to calcium dynamics, neurotransmitter release and short-term facilitation remains unknown...
April 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28410882/epo-reprograms-the-epigenome-of-erythroid-cells
#20
Andrea A Perreault, Mary Lauren Benton, Mark J Koury, Stephen J Brandt, Bryan J Venters
The hormone erythropoietin (Epo) is required for erythropoiesis, yet its molecular mechanism of action remains poorly understood, particularly in regards to chromatin dynamics. To investigate how Epo modulates the erythroid epigenome, we performed epigenetic profiling using an ex vivo murine cell system that undergoes synchronous erythroid maturation in response to Epo stimulation. Our findings define the repertoire of Epo-modulated enhancers, illuminating a new facet of Epo signaling. First, a large number of enhancers rapidly responded to Epo stimulation, revealing a cis-regulatory network of Epo-responsive enhancers...
April 11, 2017: Experimental Hematology
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