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https://www.readbyqxmd.com/read/29220803/a-single-cell-analysis-platform-for-electrochemiluminescent-detection-of-platelets-adhesion-to-endothelial-cells-based-on-au-dl-zncqds-nanoprobes
#1
Dongping Long, Yunfei Shang, Youyi Qiu, Bin Zhou, Peihui Yang
A novel single-cell analysis platform (SCA) was developed for the investigation of platelets adhesion to single human umbilical vein endothelial cell (HUVEC) via using the adhesion molecule (E-selectin) on the damaged HUVEC as the marker site, and integrating electrochemiluminescence (ECL) with the ultrasensitive Au@DL-ZnCQDs nanoprobes. The Au@DL-ZnCQDs nanocomposite, a kind of double layer zinc-coadsorbed carbon quantum dot (ZnCQDs) core-shell nanoprobe, was firstly constructed by using gold nanoparticles (AuNPs) as the core to load with ZnCQDs and then the citrate-modified silver nanoparticles (AgNPs) as the bridge to link AuNPs-ZnCQDs with ZnCQDs to form the core-shell with double layer ZnCQDs (DL-ZnCQDs) nanoprobe, revealed a 10-fold signal amplification...
November 22, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29218620/the-impact-of-injector-based-contrast-agent-administration-in-time-resolved-mra
#2
Johannes Budjan, Ulrike I Attenberger, Stefan O Schoenberg, Hubertus Pietsch, Gregor Jost
OBJECTIVES: Time-resolved contrast-enhanced MR angiography (4D-MRA), which allows the simultaneous visualization of the vasculature and blood-flow dynamics, is widely used in clinical routine. In this study, the impact of two different contrast agent injection methods on 4D-MRA was examined in a controlled, standardized setting in an animal model. METHODS: Six anesthetized Goettingen minipigs underwent two identical 4D-MRA examinations at 1.5 T in a single session...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29218559/high-resolution-distance-distributions-determined-by-x-ray-and-neutron-scattering
#3
Henry Y H Tang, John A Tainer, Greg L Hura
Measuring distances within or between macromolecules is necessary to understand the chemistry that biological systems uniquely enable. In performing their chemistry, biological macromolecules undergo structural changes over distances ranging from atomic to micrometer scales. X-ray and neutron scattering provide three key assets for tackling this challenge. First, they may be conducted on solutions where the macromolecules are free to sample the conformations that enable their chemistry. Second, there are few limitations on chemical environment for experiments...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218453/energy-depletion-and-not-ros-formation-is-a-crucial-step-of-glucolipotoxicity-gltx-in-pancreatic-beta-cells
#4
Morgana Barroso Oquendo, Nikolas Layer, Rebecca Wagner, Peter Krippeit-Drews, Gisela Drews
We have shown previously that genetic or pharmacological deletion of KATP channels protect against beta cell dysfunction induced by reactive oxygen species (ROS). Since it is assumed that glucolipotoxicity (GLTx) causes ROS production, we aimed to evaluate whether suppression of KATP channel activity can also prevent beta cell damage evoked by GLTx. We used an in vitro model of GLTx and measured distinct parameters of stimulus-secretion coupling. GLTx gradually induced disturbances of Ca2+ oscillations over 3 days...
December 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29218363/chest-computed-tomography-angiography-in-children-on-extracorporeal-membrane-oxygenation-ecmo
#5
Nathan C Hull, Gary R Schooler, Larry A Binkovitz, Eric E Williamson, Phillip A Araoz, Lifeng Yu, Philip M Young
Performing chest CT angiography on pediatric patients on extracorporeal membrane oxygenation (ECMO) can be challenging. Successfully performing CT angiography in these children requires substantial communication and coordination between the radiologists and clinical care providers. Additionally, the radiologist must understand the child's anatomy and disease pathophysiology, flow dynamics of the ECMO circuit, image acquisition timing, contrast injection site, and volume, rate and duration of contrast administration...
December 7, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29218307/calreticulin-challenges-posed-by-the-intrinsically-disordered-nature-of-calreticulin-to-the-study-of-its-function
#6
Lilian Varricchio, Mario Falchi, Massimiliano Dall'Ora, Caterina De Benedittis, Alessandra Ruggeri, Vladimir N Uversky, Anna Rita Migliaccio
Calreticulin is a Ca2+-binding chaperone protein, which resides mainly in the endoplasmic reticulum but also found in other cellular compartments including the plasma membrane. In addition to Ca2+, calreticulin binds and regulates almost all proteins and most of the mRNAs deciding their intracellular fate. The potential functions of calreticulin are so numerous that identification of all of them is becoming a nightmare. Still the recent discovery that patients affected by the Philadelphia-negative myeloproliferative disorders essential thrombocytemia or primary myelofibrosis not harboring JAK2 mutations carry instead calreticulin mutations disrupting its C-terminal domain has highlighted the clinical need to gain a deeper understanding of the biological activity of this protein...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29217685/scale-free-amplitude-modulation-of-neuronal-oscillations-tracks-comprehension-of-accelerated-speech
#7
Ana Filipa Teixeira Borges, Anne-Lise Giraud, Huibert D Mansvelder, Klaus Linkenkaer-Hansen
Speech comprehension is preserved up to a three-fold acceleration but rapidly deteriorates at higher speeds. Current models posit that perceptual resilience to accelerated speech is limited by the brain's ability to parse speech into syllabic units using delta/theta oscillations. Here, we ask whether the involvement of neuronal oscillations in processing accelerated speech also relates to their scale-free amplitude modulation as indexed by the strength of long-range temporal correlations (LRTC). We recorded magnetoencephalography (MEG) while 24 human subjects (12 females) listened to radio news uttered at different comprehensible rates, at a mostly unintelligible rate, and at this same speed interleaved with silence gaps...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217593/suboptimal-acclimation-of-photosynthesis-to-light-in-wheat-canopies
#8
Alexandra J Townsend, Renata Retkute, Kannan Chinnathambi, Jamie Wp Randall, John Foulkes, Elizabete Carmo-Silva, Erik H Murchie
Photosynthetic acclimation (photoacclimation) is the process whereby leaves alter their morphology and/or biochemistry to optimise photosynthetic efficiency and productivity according to long-term changes in the light environment. Three-dimensional (3D) architecture of plant canopies impose complex light dynamics, but the drivers for photoacclimation in such fluctuating environments are poorly understood. A technique for high-resolution 3D reconstruction was combined with ray tracing to simulate a daily time course of radiation profiles for architecturally contrasting field-grown wheat canopies...
December 7, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29217526/first-in-human-phase-i-study-of-single-agent-vanucizumab-a-first-in-class-bi-specific-anti-ang-2-anti-vegf-antibody-in-adult-patients-with-advanced-solid-tumors
#9
Manuel Hidalgo, Maria Martinez-Garcia, Christophe Le Tourneau, Christophe Massard, Elena Garralda, Valentina Boni, Alvaro Taus, Joan Albanell, Marie-Paule Sablin, Marie Alt, Rastilav Bahleda, Andreea Varga, Christophe Boetsch, Izolda Franjkovic, Florian Heil, Angelika Lahr, Katharina Lechner, Anthony Morel, Tapan K Nayak, Simona Rossomanno, Kevin Smart, Kay-Gunnar Stubenrauch, Oliver Krieter
PURPOSE: Vanucizumab is an investigational anti-angiogenic, first-in-class, bi-specific monoclonal antibody targeting VEGF-A and angiopoietin-2 (Ang-2). This first-in-human study evaluated the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of vanucizumab in adults with advanced solid tumors refractory to standard therapies. EXPERIMENTAL DESIGN: Patients received escalating bi-weekly (q2w; 3-30 mg/kg) or weekly (qw; 10-30 mg/kg) intravenous doses guided by a Bayesian logistic regression model with overdose control...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29217497/prevalence-of-hyperdense-paraspinal-vein-sign-in-patients-with-spontaneous-intracranial-hypotension-without-dural-csf-leak-on-standard-ct-myelography
#10
Michael S Clark, Felix E Diehn, Jared T Verdoorn, Vance T Lehman, Greta B Liebo, Jonathan M Morris, Kent R Thielen, John T Wald, Neeraj Kumar, Patrick H Luetmer
PURPOSE: A recently identified and treatable cause of spontaneous intracranial hypotension (SIH) is cerebrospinal fluid (CSF)-venous fistula, and a recently described computed tomography myelogram (CTM) finding highly compatible with but not diagnostic of this entity is the hyperdense paraspinal vein sign. We aimed to retrospectively measure the prevalence of the hyperdense paraspinal vein sign on CTMs in SIH patients without dural CSF leak, in comparison with control groups. METHODS: Three CTM groups were identified: 1) SIH study group, which included dural CSF leak-negative standard CTMs performed for SIH, with early and delayed imaging; 2) Early control CTMs, which were performed for indications other than SIH, with imaging shortly after intrathecal contrast administration; 3) Delayed control CTMs, which included delayed imaging...
December 7, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29217300/dynamic-magnetic-resonance-imaging-of-the-breast-comparison-of-gadobutrol-vs-gd-dtpa
#11
F Escribano, M Sentís, J C Oliva, L Tortajada, M Villajos, A Martín, S Ganau
OBJECTIVE: To compare the pharmacokinetic profile of gadobutrol versus Gd-DTPA in dynamic contrast-enhanced MRI (DCE-MRI) in patients with breast cancer. Secondary objectives included comparing the safety profiles and diagnostic efficacy of the two contrast agents for detecting additional malignant lesions. MATERIAL AND METHODS: This retrospective observational study included 400 patients with histologically confirmed breast cancer; 200 underwent DCE-MRI with Gd-DTPA (Magnevist®) and 200 underwent DCE-MRI with gadobutrol (Gadovist®)...
December 4, 2017: Radiología
https://www.readbyqxmd.com/read/29216433/aging-jamming-and-the-limits-of-stability-of-amorphous-solids
#12
Vassiliy Lubchenko, Peter G Wolynes
Apart from not having crystallized, supercooled liquids can be considered as being properly equilibrated and thus can be described by a few thermodynamic control variables. In contrast, glasses and other amorphous solids can be arbitrarily far away from equilibrium and require a description of the history of the conditions under which they formed. In this paper we describe how the locality of interactions intrinsic to finite-dimensional systems affects the stability of amorphous solids far off equilibrium. Our analysis encompasses both structural glasses formed by cooling and colloidal assemblies formed by compression...
December 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29216118/adaptive-classifier-allows-enhanced-flow-contrast-in-oct-angiography-using-a-histogram-based-motion-threshold-and-3d-hessian-analysis-based-shape-filtering
#13
Peng Li, Zhiyu Huang, Shanshan Yang, Xi Liu, Qiushi Ren, Pei Li
In this Letter, we propose an adaptive digital classifier for flow contrast enhancement in optical coherence tomography angiography (OCTA). To solve the depth dependence in the initial motion-based classification, a depth-adaptive motion threshold was determined by performing a histogram analysis of an en-face image at each depth and identifying the static and dynamic voxel populations through fitting. In the follow-up shape-based classification, to adapt to the deformed vessel shapes in OCTA, a modified vesselness function along with an anisotropic Gaussian probe kernel was defined, and then a three-dimensional (3D) Hessian analysis-based shape filtering was utilized for effectively removing the residual static voxels...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29215898/significantly-high-thermal-rectification-in-an-asymmetric-polymer-molecule-driven-by-diffusive-versus-ballistic-transport
#14
Hao Ma, Zhiting Tian
Tapered bottlebrush polymers have novel nanoscale polymer architecture. Using non-equilibrium molecular dynamics simulations, we show that these polymers have the unique ability to generate thermal rectification in a single polymer molecule and offer an exceptional platform for unveiling different heat conduction regimes. In sharp contrast to all other reported asymmetric nanostructures, we observed that the heat current from the wide end to the narrow end in tapered bottlebrush polymers is smaller than that in the opposite direction...
December 7, 2017: Nano Letters
https://www.readbyqxmd.com/read/29215272/expanded-helicenes-a-general-synthetic-strategy-and-remarkable-supramolecular-and-solid-state-behavior
#15
Gavin R Kiel, Sajan Chandresh Patel, Patrick W Smith, Daniel S Levine, T Don Tilley
A divergent synthetic strategy allowed access to several members of a new class of helicenes, the "expanded helicenes", which are composed of alternating linearly- and angularly-fused rings. The strategy is based on a threefold, partially intermolecular [2+2+n] (n = 1 or 2) cycloaddition with substrates containing three diyne units. Investigation of aggregation behavior, both in solution and the solid state, revealed that one of these compounds forms an unusual homochiral, π-stacked dimer via an equilibrium that is slow on the NMR timescale...
December 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29215261/an-interface-equilibria-triggered-time-dependent-diffusion-model-of-the-boundary-potential-and-its-application-for-the-numerical-simulation-of-the-ion-selective-electrode-response-in-real-systems
#16
Vladimir V Egorov, Andrei D Novakovskii, Elena A Zdrachek
A simple dynamic model of the phase boundary potential of ion-selective electrodes is presented. The model is based on the calculations of the concentration profiles of the components in membrane and sample solution phases by means of finite difference method. The fundamental idea behind the discussed model is that the concentration gradients in membrane and sample solution phases determine only the diffusion of the components inside corresponding phases, but not the transfer across the interface. The transfer of the components across the interface at any instant of time is determined by the corresponding local interphase equilibria...
December 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29214780/mismatch-between-tof-mr-angiography-and-ct-angiography-of-the-middle-cerebral-artery-may-be-a-critical-sign-in-cerebrovascular-dynamics
#17
Keiji Igase, Michiya Igase, Ichiro Matsubara, Kazuhiko Sadamoto
PURPOSE: Although time-of-flight (TOF)-magnetic resonance angiography (MRA) can clearly depict intracranial arteries, the arterial flow of middle cerebral artery (MCA) is occasionally not detected. We evaluated this phenomenon with reference to cerebrovascular dynamics. MATERIALS AND METHODS: Seventeen patients with suspected occlusion of MCA or internal carotid artery on TOF-MRA were enrolled. All patients underwent CT angiography (CTA) and quantitative cerebral blood flow (CBF) examination for measurement of resting CBF and cerebrovascular reactivity (CVR)...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214448/the-role-of-dynamic-post-contrast-t1-w-mri-sequence-to-characterize-lipid-rich-and-lipid-poor-adrenal-adenomas-in-comparison-to-non-adenoma-lesions-preliminary-results
#18
Valeria Romeo, Simone Maurea, Salvatore Guarino, Pier Paolo Mainenti, Raffaele Liuzzi, Mario Petretta, Immacolata Cozzolino, Michele Klain, Arturo Brunetti
PURPOSE: The purpose of the article is to compare the features of wash-out (WO) parameters between lipid-rich and lipid-poor adrenal adenomas as well as with a group of non-adenoma adrenal lesions. METHODS: 46 patients (36 F and 10 M, median age 58 years) with unilateral adrenal lesions (35 adenomas, 7 pheochromocytomas, 1 carcinoma, and 3 metastases) were prospectively evaluated; adrenal lesions were divided into adenomas (Group 1) and non-adenomas (Group 2)...
December 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29213007/the-value-of-lesion-size-as-an-adjunct-to-the-bi-rads-mri-2013-descriptors-in-the-diagnosis-of-solitary-breast-masses
#19
Makiko Kawai, Masako Kataoka, Shotaro Kanao, Mami Iima, Natsuko Onishi, Akane Ohashi, Rena Sakaguchi, Masakazu Toi, Kaori Togashi
PURPOSE: This study aimed to evaluate the MRI findings of breast solitary masses in diagnostic procedures to decide the appropriate category based on American College of Radiology (ACR) BI-RADS-MRI 2013, with the focus on lesion size. METHODS: A retrospective review of 2,603 consecutive breast MRI reports identified 250 pathologically-proven solitary breast masses. Dynamic-contrast enhanced images and diffusion-weighted images were performed on a 3.0/1.5 Tesla Scanner with a 16/4 channel dedicated breast coil...
December 7, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29212533/subtracting-the-sequence-bias-from-partially-digested-mnase-seq-data-reveals-a-general-contribution-of-tfiis-to-nucleosome-positioning
#20
Gabriel Gutiérrez, Gonzalo Millán-Zambrano, Daniel A Medina, Antonio Jordán-Pla, José E Pérez-Ortín, Xenia Peñate, Sebastián Chávez
BACKGROUND: TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been investigated. Co-transcriptional chromatin alterations include subtle changes in nucleosome positioning, like those expected to be elicited by TFIIS, which are elusive to detect. The most popular method to map nucleosomes involves intensive chromatin digestion by micrococcal nuclease (MNase)...
December 7, 2017: Epigenetics & Chromatin
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