Christopher Leroy, Jean-Louis Bourriez, Kathy Dujardin, Behnam Molaee-Ardekani, Claudio Babiloni, Dominique Deplanque, Amélie Ponchel, Sophie Hennion, Lucie Plomhause, Hervé Devanne, Julie Deguil, Pierre Payoux, Olivier Blin, Déborah Méligne, Joëlle Micallef, Nicolas Chauveau, Laura Lanteaume, Céline Vervueren, François Guimont, Claire Thalamas, Catherine Cassé-Perrot, Franck Rouby, Régis Bordet, Philippe Derambure
OBJECTIVE: To identify possible electroencephalographic (EEG) markers of donepezil's effect on cortical activity in young, healthy adult volunteers at the group level. METHODS: Thirty subjects were administered a daily dose of either 5mg donepezil or placebo for 15days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations were applied to EEG epochs...
November 27, 2015: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology