Jin-Yue Ning, Zi-Han Zhang, Jia Zhang, Yong-Min Liu, Guan-Chu Li, A-Man Wang, Ying Li, Xiu Shan, Ju-Hong Wang, Xu Zhang, Yi Zhao
Breast cancer stem cells (BCSCs) are responsible for breast cancer metastasis, recurrence and treatment resistance, all of which make BCSCs potential drivers of breast cancer aggression. Ginsenoside Rg3, a traditional Chinese herbal medicine, was reported to have multiple antitumor functions. Here, we revealed a novel effect of Rg3 on BCSCs. Rg3 inhibits breast cancer cell viability in a dose- and time-dependent manner. Importantly, Rg3 suppressed mammosphere formation, reduced the expression of stemness-related transcription factors, including c-Myc, Oct4, Sox2 and Lin28, and diminished ALDH(+) populations...
2024: American Journal of Cancer Research