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Aneurysmal bone cyst

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https://www.readbyqxmd.com/read/28605734/cervical-spine-aneurysmal-bone-cysts-in-the-pediatric-population-a-systematic-review-of-the-literature
#1
Matthew Protas, Lydia W Jones, Juan Pablo Sardi, Christian Fisahn, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs
Cervical spine aneurysmal bone cysts (ABCs) in pediatric patients have not been thoroughly studied. Using PubMed and Google Scholar, a systematic review of the literature was conducted for publications that included patients aged ≤15 years with a confirmed diagnosis of ABC in the cervical spine. Thirty-five studies with a total of 71 patients met the inclusion criteria. Nearly 80% of patients presented with neck or shoulder pain. The axis was the level most frequently involved (34.28%), followed by C5 (24...
June 13, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28597942/copy-number-alterations-determined-by-single-nucleotide-polymorphism-array-testing-in-the-clinical-laboratory-are-indicative-of-gene-fusions-in-pediatric-cancer-patients
#2
Tracy M Busse, Jacquelyn J Roth, Donna Wilmoth, Luanne Wainwright, Laura Tooke, Jaclyn A Biegel
Gene fusions resulting from structural rearrangements are an established mechanism of tumorigenesis in pediatric cancer. In this clinical cohort, 1,350 single nucleotide polymorphism (SNP)-based chromosomal microarrays from 1,211 pediatric cancer patients were evaluated for copy number alterations (CNAs) associated with gene fusions. Karyotype or fluorescence in situ hybridization studies were performed in 42% of the patients. Ten percent of the bone marrow or solid tumor specimens had SNP array-associated CNAs suggestive of a gene fusion...
June 9, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28580205/solid-variant-of-an-aneurysmal-bone-cyst-of-the-thoracic-spine
#3
Varshil Mehta, Pravin Padalkar, Maya Kale, Ambadas Kathare
The solid variant of an aneurysmal bone cyst (ABC) has been observed very rarely, especially those involving the spine. In this case report, we present a very unusual tumour of the thoracic spine which was managed by 360˚ decompression via posterior-only approach and stabilization. A 16-year-old boy presented to us with a sudden onset of weakness in both lower limbs leading to paraplegia. He also had a history of back and chest pain over the past one year. A collapse of the T5 vertebrae on plain radiograph was observed...
May 1, 2017: Curēus
https://www.readbyqxmd.com/read/28557595/chondroblastoma-an-update
#4
Wenqian Chen, Lisa M DiFrancesco
Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bones. Radiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Chondroblastoma, however, may also present with atypical features, such as prominent hemosiderin deposition, numerous giant cells, or the presence of a large aneurysmal bone cyst component...
June 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28529010/aneurysmal-bone-cyst-healing-response-with-intramedullary-lengthening-nail
#5
Ahmet Emrah Acan, Onur Basci, Hasan Havitcioglu
We report the treatment process of a pediatric patient with deformity and shortening in the arm after a recurrent aggressive aneurysmal bone cyst (ABC) in the proximal humerus. The patient was treated with curettage of the lesion and lengthening on an intramedullary nail following an osteotomy just distal to the ABC. The period of lengthening was approximately 50 days. At the end of the treatment the lengthening goal was achieved without any neurovascular complication. There was a minimal loss in shoulder hyperabduction due to the deformity of the humeral head...
May 18, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28480084/concomitant-central-giant-cell-granuloma-and-aneurysmal-bone-cyst-in-a-young-child
#6
Deepika Pai, Abhay Taranath Kamath, Adarsh Kudva, Monica Monica Charlotte Solomon, Saurabh Kumar, Prem Sasikumar
Although Central Giant Cell Granuloma (CGCG) is a benign tumor of the jaw and aneurysmal bone cyst seen in children, its aggressive behavior causes extensive loss of hard tissue requiring wide excision and extensive rehabilitation. We report a rare case of concomitant CGCG and aneurysmal bone cyst in a two-year-old male child, involving the coronoid and condylar process. Young age, large tumor, its aggressive nature, and future growth of orofacial region pose a significant challenge in the management of such conditions...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28473025/-primary-aneurysmal-bone-cyst-of-the-maxillary-sinus
#7
Annegrete Aalkjær Danielsen, Margarat Malgorzata Jensen, Victor Vishwanath Iyer
This case report describes a primary aneurysmal bone cyst in the maxillary sinus of a 50-year-old woman. She had nonspecific symptoms through four years of tearing, muscle tension in the face and neck as well as a sense of altered sound of speech. A magnetic resonance imaging of the facial skeleton showed multiple cystic processes with liquid mirror in nearly all large cysts. Histology confirmed the diagnosis of a rare aneurysmal bone cyst, and the operation was done by endoscopic resection. At the one-month post-operative control there was no recurrence...
May 1, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28463677/surgical-treatment-of-an-aneurysmal-bone-cyst-with-avascular-bone-graft
#8
Alexandru Ulici, Catalin Nahoi, Madalina Carp, Ioan Fodor, Cristina Dinu
Background: Aneurysmal bone cyst is a solitary bone tumor, expansile and lytic most often seen in the second decade of life, more frequently in men than in women (2: 1). They can occur in any bone, most common in the metaphysis of the long bones of the lower limbs. Although it is a benign tumor formation, aneurysmal cysts may have an aggressive local evolution and can cause a significant decrease in bone strength. The pacient may present local pain, the appearance of local deformation due to a tumor mass or occurrence of pathological fractures...
March 2017: Chirurgia
https://www.readbyqxmd.com/read/28454393/diagnosing-and-discriminating-between-primary-and-secondary-aneurysmal-bone-cysts
#9
Hiromi Sasaki, Satoshi Nagano, Hirofumi Shimada, Masahiro Yokouchi, Takao Setoguchi, Yasuhiro Ishidou, Osamu Kunigou, Kosuke Maehara, Setsuro Komiya
Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. In the present study, a series of 22 cases of primary and secondary ABC from patients treated in Department of Orthopedic Surgery, Kagoshima University Hospital (Kagoshima, Japan) from 2001-2015 were retrospectively analyzed. The average age at the time of diagnosis of primary ABC was 17...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451704/-benign-tumours-and-tumour-like-lesions-of-the-bone-general-treatment-principles
#10
REVIEW
H Fritzsche, K-D Schaser, C Hofbauer
BACKGROUND: Benign bone lesions are much more common than malignant lesions. Some benign bone tumors have a characteristic and typical radiographic appearance, while others are more challenging. Therapy of benign bone tumors differs greatly. While the majority of benign bone tumors do not require surgical therapy, other specific lesions, e. g. aneurysmal bone cysts or giant cell tumors (GCT) of the bone require surgery due to their locally aggressive behavior. DIAGNOSTICS: The major challenge for the radiologist and/or pathologist is the differentiation between a benign and low-grade malignant lesion (e...
April 27, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28449806/gene-fusions-pafah1b1-usp6-and-runx2-usp6-in-aneurysmal-bone-cysts-identified-by-next-generation-sequencing
#11
Mikako Warren, Dongbin Xu, Xia Li
Aneurysmal bone cyst (ABC) is a locally aggressive, expansile, typically multilocular cystic bone tumor. ABC was previously thought to be a non-neoplastic lesion; however, it is now considered to be neoplasm that features recurrent chromosomal translocations resulting in gene fusions between ubiquitin specific peptidase 6 (USP6) and multiple partners, including COL1A1, CDH11, TRAP150, ZNF90 and OMD. Using next generation sequencing (NGS), we uncovered two fusion partners of USP6 in two ABCs: platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1), which is known to contribute to tumorigenesis in lung cancer, and runt-related transcription factor 2 (RUNX2), which is known to regulate osteoblastic differentiation, osteosarcoma tumorigenesis and its metastasis...
April 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28408261/use-of-intraoperative-navigation-for-reconstruction-of-the-c1-lateral-mass-after-resection-of-aneurysmal-bone-cyst
#12
Jennifer Neva, Brandon W Smith, Jacob R Joseph, Paul Park
BACKGROUND: Aneurysmal bone cysts (ABCs) are rare blood-filled cystic lesions that are found in the long bones and spine. Here, we present a case of an ABC found in the lateral mass and lamina of C1. Lesions in this area provide a surgical challenge because of its difficulty to access as well as its need for reconstruction. We describe a novel use of intraoperative navigation (ION) to assist in the placement of a C1 lateral mass titanium cage. CASE DESCRIPTION: An 18-year-old female patient presented with headaches and progressive neck pain...
June 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28300344/intramedullary-nailing-combined-with-bone-grafting-for-benign-lesions-of-the-proximal-femur
#13
Yan Zhang, Jia-Zhen Li, Xin-Chang Lu, Yi Zhang, Huai-Shuan Zhang, Hai-Long Shi, Zheng Lei, Guang Feng, Wei-Ping Fu
OBJECTIVE: To evaluate the effectiveness of intramedullary nailing for benign lesions of the proximal femur. METHOD: A retrospective analysis was carried out on 68 cases of benign lesions in the proximal femur at our hospital from April 2002 to April 2013 (38 men and 30 women). Mean age at surgery was 35.5 years (range, 22-56 years). The cases were divided into two groups: curettage of the lesion with bone grafting only as the grafting group (32 cases) and internal fixation after removal of the lesion as the fixation group (36 cases)...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28299230/reconstruction-of-chest-wall-by-cryopreserved-sternal-allograft-after-resection-of-aneurysmal-bone-cyst-of-sternum
#14
Kambiz Sheikhy, Azizollah Abbasi Dezfouli, Farahnaz Sadegh Beigee
A 20-year-old female was referred to our hospital due to deformity and bulging in anterior aspect of chest wall in sternal area. Chest X-ray and CT scan confirmed a large mass with destruction of sternum. Pathologic diagnosis after incisional biopsy was compatible with aneurysmal bone cyst. We resected sternum completely and reconstructed large anterior defect by a cryopreserved sternal allograft. In follow-up of patient there was no unstability of chest wall with good cosmetic result.
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28289785/-incidental-findings-in-musculoskeletal-radiology
#15
F Wünnemann, C Rehnitz, M-A Weber
BACKGROUND: Increasing numbers of conventional X‑rays, computed tomography and magnetic resonance imaging in the inpatient, outpatient and scientific routine leads to an increasing number of incidental findings. The correct interpretation of these incidental findings with respect to the relevance and the evaluation concerning further work-up is an important task of radiologists. OBJECTIVE: Description of common incidental findings in musculoskeletal imaging and their clinical classification...
March 13, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28265527/aneurysmal-bone-cyst-of-the-proximal-femur-and-its-management-a-case-report
#16
Chirag Kapoor, Malkesh Shah, Rishit Soni, Jagdish Patwa, Aditya Merh, Paresh Golwala
Aneurysmal bone cyst (ABC) is a benign, expansile, non-neoplastic lesion of the bone, characterized by channels of blood and spaces that are separated by fibrous septae. Giant ABC is an uncommon condition and can be difficult to handle because of the destructive effect of the cyst on the bones and the compressive effect on the nearby structures, especially in weight-bearing bones of the body. We report a case of a giant aneurysmal bone cyst in the proximal femur of a six-year-old child, which was treated with a sclerosing agent and ender's nail fixation first...
January 23, 2017: Curēus
https://www.readbyqxmd.com/read/28211081/h3f3a-mutation-in-giant-cell-tumour-of-the-bone-is-detected-by-immunohistochemistry-using-a-monoclonal-antibody-against-the-g34w-mutated-site-of-the-histone-h3-3-variant
#17
Julian Lüke, Alexandra von Baer, Jordan Schreiber, Christoph Lübbehüsen, Thomas Breining, Kevin Mellert, Ralf Marienfeld, Markus Schultheiss, Peter Möller, Thomas F E Barth
AIMS: Giant cell tumour of the bone (GCTB) is a neoplasm predominantly of long bones characterized by the H3F3A mutation G34W. Conventional diagnosis is challenged by the tumour's giant cell-rich morphology, which overlaps with other giant cell-containing lesions of the bone. Recently, a monoclonal antibody specific for the H3F3A mutation has been generated. Our aim was to test this antibody on a cohort of giant cell-containing lesions. METHODS AND RESULTS: We used the antibody for analysis of 22 H3F3A-mutated GCTB, including two patients with recurrences; for comparison we analysed a cohort of 36 H3F3A wild-type giant cell-rich lesions of the bone and soft tissue, containing one brown tumour, six aneurysmal bone cysts (ABC), six chondroblastomas, five non-ossifying-fibromas, two fibrous dysplasias, nine tenosynovial giant cell tumours, one giant cell-rich sarcoma and six osteosarcomas...
February 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28208959/secondary-aneurysmal-bone-cyst-of-the-scapula-treated-by-ct-guided-percutaneous-polidocanol-injection-a-case-report
#18
Rahul Mohan, Gopakumar Thanuvan Sreekumaran
Aneurysmal Bone Cyst (ABC) is a rare benign tumour, usually affecting early age group and at the metaphysis of long bones. Scapular ABC's are even more rare, especially successfully treated cases. Standard treatment methods like curettage have high recurrence rates hence, adjuvant therapy may be required to avoid recurrence. Polidocanol sclerotherapy is becoming popular because of its safety and efficacy and is being tried successfully for both active as well as aggressive primary ABC of size 3-5cm. We used the same principle in a large secondary ABC of the scapula, which to the best of our knowledge has not been yet reported...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28195259/telangiectatic-osteosarcoma-of-the-rib-a-rare-entity-and-a-potential-diagnostic-pitfall
#19
I Saguem, L Ayadi, R Kallel, S Charfi, I Bahri, N Gouiaa, T Sellami-Boudawara
Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. The rib involvement is very infrequent. We present a case of TOS of the rib that posed a diagnostic difficulty owing to its unusual location and to its resemblance to giant cell tumor and aneurysmal bone cyst...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28193096/dedifferentiated-liposarcoma-of-the-retroperitoneum-with-heterologous-osteosarcomatous-differentiation-and-a-striking-aneurysmal-bone-cyst-like-morphology
#20
Carole Van Haverbeke, Jo Van Dorpe, Evelyne Lecoutere, Uta Flucke, Liesbeth Ferdinande, David Creytens
A 69-year-old woman with a 10-year medical history of recurrent retroperitoneal dedifferentiated liposarcoma presented with a 3-cm large hemorrhagic and multicystic left-sided retroperitoneal mass. Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic/osteosarcomatous differentiation and aneurysmal bone cyst-like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst-like morphology was made...
June 2017: International Journal of Surgical Pathology
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