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Aneurysmal bone cyst

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https://www.readbyqxmd.com/read/28763522/bone-haemophilic-pseudotumour-of-the-ulna-a-rare-complication-of-haemophilia-in-a-dog
#1
Adeline Decambron, Mathieu Manassero, Jean-Laurent Thibaud, Edouard Reyes-Gomez, Véronique Viateau
OBJECTIVES: This case report describes for the first time a bone haemophilic pseudotumour in a dog. CASE DESCRIPTION: A seven-month-old German Shepherd male dog was presented with the complaint of a forelimb weight-bearing lameness with major swelling that expanded dramatically after fine needle aspiration. Radiographs showed a large, well-defined ulnar diaphyseal cystic-like osteolytic lesion. Based on prolonged activated partial thromboplastin time (aPTT) and low factor VIII activity, haemophilia A was diagnosed...
August 1, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28756986/extraskeletal-aneurysmal-bone-cyst-report-of-a-case-and-review-of-the-literature
#2
Liurka V Lopez, Michael G Rodriguez, Gene P Siegal, Shi Wei
Aneurysmal bone cyst (ABC) is an expansile cystic lesion that may affect any bone of the skeleton. Although exceedingly rare, lesions with histomorphologic characteristics of an ABC have reportedly originated within soft tissue. Extraskeletal ABC may mimic a variety of benign and malignant lesions and can be confused with other more common or rare giant cell-rich tumors of soft tissue, especially myositis ossificans. Clinical, radiological and histologic correlation is crucial in reaching the correct diagnosis...
July 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28732103/denosumab-current-use-in-the-treatment-of-primary-bone-tumors
#3
Olga D Savvidou, Ioanna K Bolia, George D Chloros, John Papanastasiou, Panagiotis Koutsouradis, Panayiotis J Papagelopoulos
Denosumab, a human monoclonal antibody that inhibits bone resorption by binding on the receptor activator of the nuclear factor kappa-β ligand, has recently emerged as an additional option in the treatment of musculoskeletal osteolytic tumors. This article focuses on the recent literature regarding the effectiveness of denosumab in the management of giant cell tumor, multiple myeloma, aneurysmal bone cyst, and osteosarcoma. The mechanism of action of denosumab in the management of these tumors and the associated side effects are discussed in detail...
July 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28712047/shaped-graft-for-aneurysmal-bone-cyst-of-upper-limb-bones
#4
Mohamed F Mostafa, Yasser Y Abed, Sallam I Fawzy
The optimal treatment of aneurysmal bone cyst remains challenging. The aim of this prospective study was to evaluate the results of using bone grafts shaped to the defects caused by aneurysmal bone cysts of upper limb bones. Fifteen patients (12 males and 3 females) with an average age of 12 years (range 6-16 years) were treated for aneurysmal bone cysts of upper limb bones by intralesional resection, argon beam coagulation and shaped bone graft. The grafts were harvested from 14 patients (11 fibulas and 3 iliac bones) and from the mother of one patient (proximal fibula)...
July 15, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28702396/can-ethanol-be-used-as-an-adjuvant-to-extended-curettage-in-order-to-reduce-the-recurrence-rate-of-aneurysmal-bone-cyst
#5
Saeed Solooki, Yaghoob Keikha, Amir Reza Vosoughi
OBJECTIVE: The best treatment of aneurysmal bone cyst (ABC) is still unclear. This study aimed to evaluate the usefulness of extended curettage and ethanol as an adjuvant to reduce local recurrence of ABCs. METHODS: Retrospectively, 68 cases treated for primary and secondary ABCs caused by benign tumors from 2003 to 2013 were enrolled to a follow-up visit between one to ten years after the surgery. The treatment protocol was en-bloc resection, biopsy and curettage, extended curettage consisted of curettage, high-speed burring, ethanol 96%, and electrocauterization (combined four-step alcohol-using approach) followed by defect filling, consecutively...
May 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28694603/hydatid-disease-of-the-spine-a-rare-case
#6
Mona Agnihotri, Naina Goel, Asha Shenoy, Survendra Rai, Atul Goel
Hydatid disease or hydatidosis is the most widespread zoonosis caused by Echinococcus granulosus. Liver and lungs are the most common sites. Bone involvement is rare and reported in 0.5%-4% with spinal involvement reported in 50% of these cases. We present a case of spinal hydatidosis in a 35-year-old male presenting with lower extremity weakness and numbness. Magnetic resonance imaging (MRI) of the spine showed multiple cystic lesions at the T9-T11 level with involvement of the paraspinal muscles. The lesion was seen intraspinal, intradural, intramedullary, and epidural...
April 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28658921/an-unusual-radiographic-presentation-of-aneurysmal-bone-cyst-of-the-zygoma-a-rare-case-report
#7
Gv Murali Gopika Manoharan, Priyanka Khobre, Jayaraman Balaji, Mukesh Singh
Aneurysmal Bone Cyst (ABC) is an uncommon benign lesion affecting mainly the long bones and vertebral column. Its occurrence in the maxillofacial skeleton is rare. So far only five cases of ABC in the zygoma have been reported in the literature. Radiographic features of ABC are not pathognomonic. There can be expansion of bone and it may manifest as cystic lesion with honeycomb or soap bubble appearance. There can be perforation or destruction of cortex of the bone as well. Therefore the differential diagnosis of ABC is quite conflicting with other types of maxillary bone lesions...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28605734/cervical-spine-aneurysmal-bone-cysts-in-the-pediatric-population-a-systematic-review-of-the-literature
#8
Matthew Protas, Lydia W Jones, Juan Pablo Sardi, Christian Fisahn, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs
Cervical spine aneurysmal bone cysts (ABCs) in pediatric patients have not been thoroughly studied. Using PubMed and Google Scholar, a systematic review of the literature was conducted for publications that included patients aged ≤15 years with a confirmed diagnosis of ABC in the cervical spine. Thirty-five studies with a total of 71 patients met the inclusion criteria. Nearly 80% of patients presented with neck or shoulder pain. The axis was the level most frequently involved (34.28%), followed by C5 (24...
2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28597942/copy-number-alterations-determined-by-single-nucleotide-polymorphism-array-testing-in-the-clinical-laboratory-are-indicative-of-gene-fusions-in-pediatric-cancer-patients
#9
Tracy M Busse, Jacquelyn J Roth, Donna Wilmoth, Luanne Wainwright, Laura Tooke, Jaclyn A Biegel
Gene fusions resulting from structural rearrangements are an established mechanism of tumorigenesis in pediatric cancer. In this clinical cohort, 1,350 single nucleotide polymorphism (SNP)-based chromosomal microarrays from 1,211 pediatric cancer patients were evaluated for copy number alterations (CNAs) associated with gene fusions. Karyotype or fluorescence in situ hybridization studies were performed in 42% of the patients. Ten percent of the bone marrow or solid tumor specimens had SNP array-associated CNAs suggestive of a gene fusion...
October 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28580205/solid-variant-of-an-aneurysmal-bone-cyst-of-the-thoracic-spine
#10
Varshil Mehta, Pravin Padalkar, Maya Kale, Ambadas Kathare
The solid variant of an aneurysmal bone cyst (ABC) has been observed very rarely, especially those involving the spine. In this case report, we present a very unusual tumour of the thoracic spine which was managed by 360˚ decompression via posterior-only approach and stabilization. A 16-year-old boy presented to us with a sudden onset of weakness in both lower limbs leading to paraplegia. He also had a history of back and chest pain over the past one year. A collapse of the T5 vertebrae on plain radiograph was observed...
May 1, 2017: Curēus
https://www.readbyqxmd.com/read/28557595/chondroblastoma-an-update
#11
Wenqian Chen, Lisa M DiFrancesco
Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bones. Radiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Chondroblastoma, however, may also present with atypical features, such as prominent hemosiderin deposition, numerous giant cells, or the presence of a large aneurysmal bone cyst component...
June 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28529010/aneurysmal-bone-cyst-healing-response-with-intramedullary-lengthening-nail
#12
Ahmet Emrah Acan, Onur Basci, Hasan Havitcioglu
We report the treatment process of a pediatric patient with deformity and shortening in the arm after a recurrent aggressive aneurysmal bone cyst (ABC) in the proximal humerus. The patient was treated with curettage of the lesion and lengthening on an intramedullary nail following an osteotomy just distal to the ABC. The period of lengthening was approximately 50 days. At the end of the treatment the lengthening goal was achieved without any neurovascular complication. There was a minimal loss in shoulder hyperabduction due to the deformity of the humeral head...
May 18, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28480084/concomitant-central-giant-cell-granuloma-and-aneurysmal-bone-cyst-in-a-young-child
#13
Deepika Pai, Abhay Taranath Kamath, Adarsh Kudva, Monica Monica Charlotte Solomon, Saurabh Kumar, Prem Sasikumar
Although Central Giant Cell Granuloma (CGCG) is a benign tumor of the jaw and aneurysmal bone cyst seen in children, its aggressive behavior causes extensive loss of hard tissue requiring wide excision and extensive rehabilitation. We report a rare case of concomitant CGCG and aneurysmal bone cyst in a two-year-old male child, involving the coronoid and condylar process. Young age, large tumor, its aggressive nature, and future growth of orofacial region pose a significant challenge in the management of such conditions...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28473025/-primary-aneurysmal-bone-cyst-of-the-maxillary-sinus
#14
Annegrete Aalkjær Danielsen, Margarat Malgorzata Jensen, Victor Vishwanath Iyer
This case report describes a primary aneurysmal bone cyst in the maxillary sinus of a 50-year-old woman. She had nonspecific symptoms through four years of tearing, muscle tension in the face and neck as well as a sense of altered sound of speech. A magnetic resonance imaging of the facial skeleton showed multiple cystic processes with liquid mirror in nearly all large cysts. Histology confirmed the diagnosis of a rare aneurysmal bone cyst, and the operation was done by endoscopic resection. At the one-month post-operative control there was no recurrence...
May 1, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28463677/surgical-treatment-of-an-aneurysmal-bone-cyst-with-avascular-bone-graft
#15
Alexandru Ulici, Catalin Nahoi, Madalina Carp, Ioan Fodor, Cristina Dinu
Background: Aneurysmal bone cyst is a solitary bone tumor, expansile and lytic most often seen in the second decade of life, more frequently in men than in women (2: 1). They can occur in any bone, most common in the metaphysis of the long bones of the lower limbs. Although it is a benign tumor formation, aneurysmal cysts may have an aggressive local evolution and can cause a significant decrease in bone strength. The pacient may present local pain, the appearance of local deformation due to a tumor mass or occurrence of pathological fractures...
March 2017: Chirurgia
https://www.readbyqxmd.com/read/28454393/diagnosing-and-discriminating-between-primary-and-secondary-aneurysmal-bone-cysts
#16
Hiromi Sasaki, Satoshi Nagano, Hirofumi Shimada, Masahiro Yokouchi, Takao Setoguchi, Yasuhiro Ishidou, Osamu Kunigou, Kosuke Maehara, Setsuro Komiya
Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. In the present study, a series of 22 cases of primary and secondary ABC from patients treated in Department of Orthopedic Surgery, Kagoshima University Hospital (Kagoshima, Japan) from 2001-2015 were retrospectively analyzed. The average age at the time of diagnosis of primary ABC was 17...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451704/-benign-tumours-and-tumour-like-lesions-of-the-bone-general-treatment-principles
#17
REVIEW
H Fritzsche, K-D Schaser, C Hofbauer
BACKGROUND: Benign bone lesions are much more common than malignant lesions. Some benign bone tumors have a characteristic and typical radiographic appearance, while others are more challenging. Therapy of benign bone tumors differs greatly. While the majority of benign bone tumors do not require surgical therapy, other specific lesions, e. g. aneurysmal bone cysts or giant cell tumors (GCT) of the bone require surgery due to their locally aggressive behavior. DIAGNOSTICS: The major challenge for the radiologist and/or pathologist is the differentiation between a benign and low-grade malignant lesion (e...
April 27, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28449806/gene-fusions-pafah1b1-usp6-and-runx2-usp6-in-aneurysmal-bone-cysts-identified-by-next-generation-sequencing
#18
Mikako Warren, Dongbin Xu, Xia Li
Aneurysmal bone cyst (ABC) is a locally aggressive, expansile, typically multilocular cystic bone tumor. ABC was previously thought to be a non-neoplastic lesion; however, it is now considered to be neoplasm that features recurrent chromosomal translocations resulting in gene fusions between ubiquitin specific peptidase 6 (USP6) and multiple partners, including COL1A1, CDH11, TRAP150, ZNF90 and OMD. Using next generation sequencing (NGS), we uncovered two fusion partners of USP6 in two ABCs: platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1), which is known to contribute to tumorigenesis in lung cancer, and runt-related transcription factor 2 (RUNX2), which is known to regulate osteoblastic differentiation, osteosarcoma tumorigenesis and its metastasis...
April 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28408261/use-of-intraoperative-navigation-for-reconstruction-of-the-c1-lateral-mass-after-resection-of-aneurysmal-bone-cyst
#19
Jennifer Neva, Brandon W Smith, Jacob R Joseph, Paul Park
BACKGROUND: Aneurysmal bone cysts (ABCs) are rare blood-filled cystic lesions that are found in the long bones and spine. Here, we present a case of an ABC found in the lateral mass and lamina of C1. Lesions in this area provide a surgical challenge because of its difficulty to access as well as its need for reconstruction. We describe a novel use of intraoperative navigation (ION) to assist in the placement of a C1 lateral mass titanium cage. CASE DESCRIPTION: An 18-year-old female patient presented with headaches and progressive neck pain...
June 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28300344/intramedullary-nailing-combined-with-bone-grafting-for-benign-lesions-of-the-proximal-femur
#20
Yan Zhang, Jia-Zhen Li, Xin-Chang Lu, Yi Zhang, Huai-Shuan Zhang, Hai-Long Shi, Zheng Lei, Guang Feng, Wei-Ping Fu
OBJECTIVE: To evaluate the effectiveness of intramedullary nailing for benign lesions of the proximal femur. METHOD: A retrospective analysis was carried out on 68 cases of benign lesions in the proximal femur at our hospital from April 2002 to April 2013 (38 men and 30 women). Mean age at surgery was 35.5 years (range, 22-56 years). The cases were divided into two groups: curettage of the lesion with bone grafting only as the grafting group (32 cases) and internal fixation after removal of the lesion as the fixation group (36 cases)...
February 2017: Orthopaedic Surgery
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