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Aneurysmal bone cyst

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https://www.readbyqxmd.com/read/29787930/fibro-osseous-pseudotumor-of-digits-expanding-the-spectrum-of-clonal-transient-neoplasms-harboring-usp6-rearrangement
#1
Uta Flucke, Sarah J Shepard, Elise M Bekers, Roberto Tirabosco, Paul J van Diest, David Creytens, Joost M van Gorp
Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Of the five patients included, three were female and two were male...
May 12, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29757500/immunohistochemistry-for-histone-h3g34w-and-h3k36m-is-highly-specific-for-giant-cell-tumor-of-bone-and-chondroblastoma-respectively-in-fna-and-core-needle-biopsy
#2
Inga-Marie Schaefer, Jonathan A Fletcher, G Petur Nielsen, Angela R Shih, Marco L Ferrone, Jason L Hornick, Xiaohua Qian
BACKGROUND: Diagnosing giant cell-rich bone tumors can be challenging on limited biopsies. H3 histone family member 3A (H3F3A) (G34W/V/R/L) mutations are present in the majority of giant cell tumors (GCTs) of bone and H3 histone family member 3B (H3F3B) (K36M) mutations are present in nearly all chondroblastomas, but are absent in histologic mimics. Mutation-specific immunohistochemistry (IHC) is highly specific for GCT and chondroblastoma in surgical excisions. The objective of the current study was to validate H3G34W and H3K36M IHC in the diagnosis of giant cell-rich bone tumors on fine-needle aspiration and core needle biopsy specimens...
May 14, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29744853/fibrous-dysplasia-clinicopathologic-presentation-of-36-cases
#3
Mine Özşen, Ülviye Yalçinkaya, Muhammed Sadık Bilgen, Zeynep Yazici
OBJECTIVE: Fibrous dysplasia is a slowly progressing bone lesion resulting from displacement of the normal medullary bone with abnormal fibroosseous tissue. The aim of this study was to assess the similarities and differences of our cases in relation to published reports. MATERIAL AND METHOD: In this study, the archives of the Uludag University Medical Faculty Department of Pathology were screened for fibrous dysplasia cases between 2004 and 2016. RESULTS: Within the mentioned period, there were 36 cases diagnosed as fibrous dysplasia...
May 10, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29742594/capillary-hemangioma-as-an-unusual-cause-of-doughnut-sign-on-bone-scan
#4
Omar Q Samarah, Mohammad I Tayyem, Nisreen Abu Shahin, Ghadeer AlMuhaisen, Malik E Juweid
A 28-year-old woman presented with a mass in her right leg, which, on plain radiograph, appeared as a lytic lesion in the mid-shaft of the tibia with cortical thinning but without periosteal reaction. Tc-MDP 3-phase bone scan demonstrated intense uptake in the periphery of the mass with a photopenic center, the so-called doughnut sign. Histopathology revealed a capillary hemangioma. This case demonstrates that the doughnut sign on bone scan can be caused by capillary hemangioma in addition to other reported bone pathologies, including aneurysmal bone cyst, giant cell tumor, and telangiectatic osteosarcoma...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29738344/giant-cell-tumor-of-the-ribs-and-aneurysmal-bone-cyst-presenting-with-hemothorax-in-a-child-erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
May 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29735505/osteitis-fibrosa-cystica-masquerading-as-bone-neoplasm
#6
Vishnu Vardhan Garla, Israh Akhtar, Sohail Salim, Angela Subauste
A 50-year-old female patient with no significant medical history presented with left knee pain. Radiographs of the knee showed a circumferential swelling of the distal femur suggestive of neoplasia. Further evaluation revealed multiple lesions in the left iliac bone and proximal femur. Biopsy was suggestive of a reparative granuloma or an aneurysmal bone cyst. Laboratory assessment showed hypercalcaemia and elevated parathyroid hormone consistent with severe primary hyperparathyroidism. Osseous survey was significant for salt and pepper appearance of the skull...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29733532/mandibular-aneurysmal-bone-cyst-in-an-elderly-patient-case-report
#7
Cristian Rațiu, Aranka Ilea, Florin A Gal, Flavia Ruxanda, Bianca A Boşca, Viorel Miclăuș
OBJECTIVE: The article aims to highlight the challenge of establishing the presumptive aetiological diagnosis when unilocular or multilocular radiolucencies are identified in an elderly patient's jawbones. MATERIALS AND METHODS: A mandibular cyst-like lesion was identified in a 73-year-old patient. The therapeutic decision was cyst enucleation and grafting of the bone defect. RESULTS: The initial presumptive diagnosis was invalidated by the histopathological examination that revealed the features characteristic for the aneurysmal bone cyst...
June 2018: Gerodontology
https://www.readbyqxmd.com/read/29661729/myositis-ossificans-another-condition-with-usp6-rearrangement-providing-evidence-of-a-relationship-with-nodular-fasciitis-and-aneurysmal-bone-cyst
#8
Elise M Bekers, Astrid Eijkelenboom, Katrien Grünberg, Rona C Roverts, Jacky W J de Rooy, Ingrid C M van der Geest, Joost M van Gorp, David Creytens, Uta Flucke
Myositis ossificans is defined as a self-limiting pseudotumor composed of reactive hypercellular fibrous tissue and bone. USP6 rearrangements have been identified as a consistent genetic driving event in aneurysmal bone cyst and nodular fasciitis. It is therefore an integral part of the diagnostic workup when dealing with (myo)fibroblastic lesions of soft tissue and bone. Two cases of myositis ossificans with USP6 rearrangement were published so far. We determine herein the incidence of USP6 rearrangement in myositis ossificans using USP6 fluorescence in situ hybridization analysis (FISH)...
January 12, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661070/scaphoid-cysts-literature-review-of-etiology-treatment-and-prognosis
#9
Tyler Safran, Jessica Hazan, Becher Al-Halabi, Hassan Al-Naeem, Sabrina Cugno
BACKGROUND: Cystic lesions of the carpal bones are rare entities that are infrequently reported in the literature. Scaphoid intraosseous cystic lesions represent a rare subset of carpal bone cysts. This review aims to summarize the available evidence on the evaluation and treatment of scaphoid cystic lesions to help guide clinical management. METHODS: Systematic electronic searches were performed using PubMed, Ovid, and Embase databases. Studies included were graded for their risk of bias...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29611530/periosteal-aneurysmal-bone-cyst
#10
Thamer M Alraiyes, Nikolaos A Stavropoulos, Abdulrahman Alaseem, Sungmi Jung, Robert E Turcotte
No abstract text is available yet for this article.
April 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29599183/embolization-through-the-thyrocervical-trunk-vascular-anatomy-variants-and-a-case-series
#11
Carlos Pérez-García, Carlos Malfaz, Mariano Del Valle Diéguez, Fernando Fortea Gil, Javier Saura Lorente, Miguel Echenagusia Boyra, Manuel González Leyte, Antonio Pérez-Higueras, Enrique Castro-Reyes
BACKGROUND AND PURPOSE: The thyrocervical trunk (TCT) is the second ascending branch of the subclavian artery. It is considered a 'border territory' between interventional vascular radiology and interventional neuroradiology because it gives rise to branches both cervical and to the upper limbs. We describe the TCT branches anatomy, the most frequent variants, and expose eight endovascular procedures performed through the thyrocervical trunk. METHODS: A retrospective review of all the interventional radiology procedures carried out through the TCT in our tertiary care center from August 2014 to January 2017 is presented...
March 29, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29580573/-benign-and-malignant-giant-cell-rich-lesions-of-bone-pathological-diagnosis-with-special-emphasis-on-recent-immunohistochemistry-and-molecular-techniques
#12
Nicolas Macagno, Kevin Caselles, Sébastien Aubert, Virginie Audard, Anne Gomez-Brouchet, Christine Galant, Jean-Marc Guinebretière, Marie Karanian, Frédérique Larousserie, Béatrice Marie, Gonzague de Pinieux, Corinne Bouvier
The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Amongst malignant neoplasms, variants of conventional osteosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma and bone metastasis must be discussed...
March 23, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29549420/-morphological-spectrum-of-usp6-rearranged-lesions
#13
G Mechtersheimer, M Werner
USP6, also known as Tre-2 and TRE17, is an ubiquitase-specific proteinase that was identified more than two decades ago as a potential oncogene when it exhibited transforming properties upon overexpression in NIH 3T3 cells. Until recently, however, little was known about the function and the oncogenetic activation of USP6. The identification of rearrangements of the USP6 gene in aneurysmal bone cyst and in nodular fasciitis has not only led to a better understanding of the pathogenesis of these entities, but is also a useful tool in their diagnosis and differential diagnostic delineation from morphological mimics...
March 2018: Der Pathologe
https://www.readbyqxmd.com/read/29540050/do-multiple-fluid-fluid-levels-on-mri-always-reveal-primary-benign-aneurysmal-bone-cyst
#14
Marco Girolami, Silvio Caravelli, Valentina Persiani, Riccardo Ghermandi, Alessandro Gasbarrini
No abstract text is available yet for this article.
April 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29529643/is-core-needle-biopsy-reliable-in-differentiating-between-aggressive-benign-and-malignant-radiolucent-bone-tumors
#15
Vishal Hegde, Zachary D C Burke, Howard Y Park, Stephen D Zoller, Daniel Johansen, Benjamin V Kelley, Ben Levine, Kambiz Motamedi, Noah C Federman, Leanne L Seeger, Scott D Nelson, Nicholas M Bernthal
BACKGROUND: Although there is widespread acceptance of core needle biopsy (CNB) for diagnosing solid tumors, there is reluctance by some clinicians to use CNB for aneurysmal bone cysts (ABCs) as a result of concerns of safety (bleeding, nerve injury, fracture, readmission, or infection) and reliability, particularly to rule out malignant diagnoses like telangiectatic osteosarcoma. This is especially true when CNB tissue is sent from an outside hospital, where the technique used to obtain the tissue may be spurious...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29496068/ct-guided-radiofrequency-ablation-in-patients-with-aneurysmal-bone-cysts
#16
Osama A Zarzour, Fernando Ruiz Santiago, Nicolas Olea Serrano, Abdelkareem Hassan Abdallah, Mostafa Ahmad El-Sharkawy, Amr Farouk Mourad
INTRODUCTION: Aneurysmal bone cyst (ABC) is one of most therapeutic challenging lesions for orthopedic surgeons specially in large-sized lesions and lesions, which are very close to important neurovascular structures. In the present study, we express our experience in the treatment of aneurysmal bone cyst by radiofrequency thermal ablation (RFTA). METHODS: In the last two years, we have treated 20 cases (12 males & 8 females) presented with painful aneurysmal bone cysts in different anatomical locations, the age mean (±SD) is 18...
March 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29492610/treatment-of-the-aneurysmal-bone-cyst-by-percutaneous-intracystic-sclerotherapy-using-ethanol-ninety-five-percent-in-children
#17
Alexandru Ulici, Daniel-Catalin Florea, Madalina Carp, Alin Ladaru, Iulia Tevanov
INTRODUCTION: Aneurysmal bone cyst (ABC) is a benign intraosseous lesion filled with blood that can determine a blowout distension of the bone. The purpose of this study is to evaluate the efficacy of sclerotherapy by percutaneous intralesional administration of ethanol 96% for the treatment of this pathology in paediatric patients. METHOD: The retrospective study includes 17 paediatric patients with ABC who were treated by repeated intracystic injection with ethanol 96%, 1 ml/kg, in our clinic between December 2015 and July 2017...
February 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29489506/expression-of-h3-3-g34w-distinguishes-giant-cell-tumor-of-bone-from-its-major-giant-cell-containing-bone-and-soft-tissue-mimics-in-particular-aneurysmal-bone-cyst-and-giant-cell-tumor-of-soft-tissue
#18
David Creytens
No abstract text is available yet for this article.
February 27, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29473522/an-evidence-based-review-of-off-label-uses-of-polidocanol
#19
Seyyed Reza Sadat Ebrahimi, Elgar Enamzadeh, Hossein Babaei
BACKGROUND: Polidocanol is approved for its competence in the treatment of varicose veins and spider veins; however, unfortunately, many of its off-label uses are still underappreciated. OBJECTIVE: Lack of an appropriate comprehensive review for off-label uses of this medication troubles physicians about making evidence-based decisions on prescribing it for its various outstanding off-label uses. This article attempts to provide physicians with the latest information concerning successful and unsuccessful use of polidocanol as an alternative treatment for esophageal and gastric varices, tendinopathy and epicondylitis, vascular malformations, varicocele, hydrocele and spermatocele, aneurysmal bone cysts, itching, management of gastrointestinal bleeding, simple renal cysts, reducing the incidence and severity of radio-induced dermatitis and hemorrhoids...
2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29470716/denosumab-a-potential-treatment-option-for-aneurysmal-bone-cyst-of-the-atlas
#20
REVIEW
Ravish Shammi Patel, Chetan Anil Dhamne, Anil Gopinathan, Nishant Kumar, Naresh Kumar
PURPOSE: Aneurysmal bone cysts (ABCs) of spine are conventionally treated with en-bloc resection or intralesional excision/curettage and reconstruction or filling of defects with bone cement. For the treatment of upper cervical ABCs, en-bloc resections are often not desirable considering the risk/benefit ratio while the risk of recurrence after intralesional excision is high. Hence, alternative management options are often necessary. We describe our clinical experience with one such treatment alternative-denosumab for the treatment of ABC of Atlas...
February 22, 2018: European Spine Journal
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