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https://www.readbyqxmd.com/read/28426710/change-in-iron-metabolism-in-rats-after-renal-ischemia-reperfusion-injury
#1
Guang-Liang Xie, Lin Zhu, Yan-Min Zhang, Qian-Nan Zhang, Qing Yu
Previous studies have indicated that hepcidin, which can regulate iron efflux by binding to ferroportin-1 (FPN1) and inducing its internalization and degradation, acts as the critical factor in the regulation of iron metabolism. However, it is unknown whether hepcidin is involved in acute renal ischemia/reperfusion injury (IRI). In this study, an IRI rat model was established via right renal excision and blood interruption for 45 min in the left kidney, and iron metabolism indexes were examined to investigate the change in iron metabolism and to analyze the role of hepcidin during IRI...
2017: PloS One
https://www.readbyqxmd.com/read/28425165/melanogenesis-inhibitory-and-cytotoxic-activities-of-limonoids-alkaloids-and-phenolic-compounds-from-phellodendron-amurense-bark
#2
Toshihiro Akihisa, Satoru Yokokawa, Eri Ogihara, Masahiro Matsumoto, Jie Zhang, Takashi Kikuchi, Kazuo Koike, Masahiko Abe
Four limonoids, 1-4, five alkaloids, 5-9, and four phenolic compounds, 10-13, were isolated from a MeOH extract of the bark of Phellodendron amurense (Rutaceae). Among these, compound 13 was a new, and its structure was established as rel-(1R,2R,3R)-5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1-(methoxycarbonylmethyl)indane-2-carboxylic acid methyl ester (γ-di(methyl ferulate)) based on the spectrometric analysis. Upon evaluation of compounds 1-13 against the melanogenesis in the B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), four compounds, limonin (1), noroxyhydrastinine (6), haplopine (7), and 4-methoxy-N-methyl-2-quiolone (8), exhibited potent melanogenesis-inhibitory activities with almost no toxicity to the cells...
April 20, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28424736/a-case-of-xanthogranulomatous-pyelonephritis-associated-with-renoduodenal-fistula
#3
R Conor Holton-Burke, Mini Varughese
Xanthogranulomatous pyelonephritis (XGP) is a rare form of pyelonephritis associated with repeated infection, chronic inflammation, and obstruction. Various fistulas, including those to the intestine, are a known association with XGP. Here, a 55-year-old woman with a history of multiple previous renal calculi presented with dysuria and back pain. Contrast-enhanced computed tomography (CT) revealed a soft tissue density in her renal pelvis and perirenal space consistent with XGP along with a tract connecting the upper pole of her right kidney to the second portion of the duodenum...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#4
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
April 19, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28421832/experimental-induction-of-chicken-aa-amyloidosis-in-white-layer-chickens-by-inoculation-with-inactivated-vaccines
#5
Wazir Ahmad Habibi, Takuya Hirai, Mohammad Hakim Niazmand, Naoko Okumura, Ryoji Yamaguchi
We investigated the amyloidogenic potential of inactivated vaccines and the localized production of serum amyloid A (SAA) at the injection site in white layer chickens. Hens in the treated group were injected intramuscularly three times with high doses of inactivated oil-emulsion Salmonella Enteritidis vaccine and multivalent viral and bacterial inactivated oil-emulsion vaccines at two week intervals. Chickens in the control group did not receive any inoculum. In the treated group, emaciation, and granulomas were present, while several chickens died between 4-6 weeks after the first injection...
April 19, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28421810/catheter-traction-and-gastric-outlet-obstruction-a-repeated-complication-of-using-a-foley-catheter-for-gastrostomy-tube-replacement
#6
Jorge Fonseca, Gonçalo Nunes, Marta Patita, Rita Barosa, Carla Adriana Santos
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is a safe procedure and major morbidity is unusual. However, the number of PEG fed patients is increasing all over the world and complications may become more and more frequent. CASE REPORT: We describe a 73 years old woman with persistent vomit after replacement of the standard PEG tube with a Foley catheter. An upper GI endoscopy showed the catheter pulled into the duodenum causing gastric outlet obstruction...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28420890/endoscopic-manifestations-and-clinical-characteristics-of-cytomegalovirus-infection-in-the-upper-gastrointestinal-tract
#7
Masaya Iwamuro, Eisei Kondo, Takehiro Tanaka, Hideharu Hagiya, Seiji Kawano, Yoshiro Kawahara, Fumio Otsuka, Hiroyuki Okada
We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD)...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28420122/the-effect-of-salt-intake-and-potassium-supplementation-on-serum-gastrin-levels-in-chinese-adults-a-randomized-trial
#8
Yuan-Yuan Wang, Wen-Wen He, Yan-Chun Liu, Yi-Feng Lin, Lu-Fei Hong
Excess dietary salt is strongly correlated with cardiovascular disease, morbidity, and mortality. Conversely, potassium likely elicits favorable effects against cardiovascular disorders. Gastrin, which is produced by the G-cells of the stomach and duodenum, can increase renal sodium excretion and regulate blood pressure by acting on the cholecystokinin B receptor. The aim of our study was to assess the effects of altered salt and potassium supplementation on serum gastrin levels in humans. A total of 44 subjects (38-65 years old) were selected from a rural community in northern China...
April 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28419329/effects-of-the-inclusion-of-a-bacillus-direct-fed-microbial-on-performance-parameters-bone-quality-recovered-gut-microflora-and-intestinal-morphology-in-broilers-consuming-a-grower-diet-containing-corn-distillers-dried-grains-with-solubles
#9
J D Latorre, X Hernandez-Velasco, J L Vicente, R Wolfenden, B M Hargis, G Tellez
Distillers dried grains with solubles (DDGS) have increasingly been used in poultry diets as a consequence of rising grain costs. Some, but not all, sources of DDGS have a variable compositional value, and a high inclusion of this by-product could be considered a risk factor for presentation of enteric diseases. Presently, 2 experiments were conducted using a starter corn-soybean diet (zero to 7 d) and a corn-DDGS-soybean grower diet (8 to 28 d) with or without inclusion of a Bacillus-direct-fed microbial (DFM)...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28418917/expression-of-guanylyl-cyclase-c-in-tissue-samples-and-the-circulation-of-rectal-cancer-patients
#10
Yong Liu, Guoping Cheng, Jun Qian, HaiXing Ju, YuPing Zhu, Meucci Stefano, Ulrich Keilholz, DeChuan Li
Guanylyl cyclase C (GCC) is a transmembrane surface receptor restricted to intestinal epithelial cells, from the duodenum to the rectum. We compared GCC expression in tumors and normal rectal tissues, and investigated the relation between GCC expression and metastasis and long-term survival of rectal cancer patients. Based on the UICC classification, 42 rectal cancer patients in this study were classified as stage I, 48 patients as stage II, and 90 patients as stage III. Overexpression of GCC was observed in 80 rectal tumors as compared to matched normal tissues, where no strong staining of GCC was observed...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417289/reporting-the-margin-in-pancreaticoduodenectomies-r0-versus-r1
#11
Chandralekha Shyamsunder Tampi, Somesh Nilkanth, Palepu Jagannath
AIM: This study was conducted to analyze the changes in margin positivity in pancreaticoduodenectomies, on using a standardized protocol, which bread loafs the pancreas and duodenum in the axial plane for adenocarcinomas arising in the pancreatic head, ampulla, terminal common bile duct (CBD), and duodenum, and then to assess whether these tumor subsets involve the margins in different ways. METHODS: The analysis was performed on 70 consecutive specimens, the pre-protocol specimens serving as the control group...
April 18, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28416061/-bouveret-s-syndrome-a-rare-complication-in-connection-with-cholecystolithiasis-and-a-variant-of-gallstone-ileus
#12
Mik Wetterslev, Simon Bernth Andersen, Jens Støvring
Bouveret's syndrome is a very rare complication to cholecystolithiasis resulting in gallstone ileus. It is caused by ectopic gallstones in the duodenum due to a bilioenteric fistula. Symptoms may include vomiting and upper abdominal pains. The condition is associated with high mortality, making it important to recognize. The treatment includes surgical removal of the gallstone. However, the optimal therapeutic approach has still not been found. In this case report a 59-year-old female with Bouveret's syndrome is presented...
April 17, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28415799/the-pancreas-responds-to-remote-damage-and-systemic-stress-by-secretion-of-the-pancreatic-secretory-proteins-psp-regi-and-pap-regiii
#13
Theresia Reding, Cristian Palmiere, Clinsyjos Pazhepurackel, Marc Schiesser, Daniel Bimmler, Andrea Schlegel, Ursula Süss, Sabrina Steiner, Leandro Mancina, Gitta Seleznik, Rolf Graf
INTRODUCTION: In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly elevated. The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, pancreatitis-associated protein (PAP) was identified in the pancreas. These proteins were also localized in intestinal organs. Here we aim to elucidate the bio-distribution of PSP and PAP in animal models of sepsis and in healthy humans...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414135/gastrointestinal-behavior-of-itraconazole-in-humans-part-1-supersaturation-from-a-solid-dispersion-and-a-cyclodextrin-based-solution
#14
Joachim Brouwers, Sophie Geboers, Raf Mols, Jan Tack, Patrick Augustijns
This study evaluated the fasted state gastrointestinal behavior of the lipophilic drug itraconazole, orally administered to healthy volunteers as either a solid dispersion (Sporanox(®) capsules) or a cyclodextrin-based solution (Sporanox(®) solution). Following intake of the drug products, gastric and duodenal fluids were aspirated and analyzed for itraconazole concentration, total content and solubilizing capacity. Release of itraconazole from the solid dispersion generated high and metastable supersaturated levels in the stomach, but the dissolved fraction in the duodenum remained extremely low (median 2...
April 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28413860/distribution-and-characterisation-of-cck-containing-enteroendocrine-cells-of-the-mouse-small-and-large-intestine
#15
Josiane Fakhry, Joyce Wang, Patricia Martins, Linda J Fothergill, Billie Hunne, Pierre Prieur, Arthur Shulkes, Jens F Rehfeld, Brid Callaghan, John B Furness
There is general consensus that enteroendocrine cells, EEC, containing the enteric hormone cholecystokinin (CCK) are confined to the small intestine and predominate in the duodenum and jejunum. Contrary to this, EEC that express the gene for CCK have been isolated from the large intestine of the mouse and there is evidence for EEC that contain CCK-like immunoreactivity in the mouse colon. However, the human and rat colons do not contain CCK cells. In the current study, we use immunohistochemistry to investigate CCK peptide presence in endocrine cells, PCR to identify cck transcripts and chromatography to identify CCK peptide forms in the mouse small and large intestine...
April 17, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28413438/a-case-report-of-brief-psychotic-disorder-with-catalepsy-associated-with-sequential-life-threatening-events-in-a-patient-with-advanced-cancer
#16
Mayumi Ishida, Satoshi Kawada, Hideki Onishi
BACKGROUND: Cancer is commonly perceived as life-threatening and universally stressful; however, brief psychotic disorder, which occurs in response to extremely stressful events, has not been reported. CASE PRESENTATION: A 63-year-old woman, who was diagnosed as having pancreatic cancer with liver metastasis, became unresponsive with very little reaction to verbal contact after sequential life-threatening events, such as thrombosis of both pulmonary arteries and stenosis of the third portion of the duodenum, due to disease progression over 3 weeks beginning with oncological emergency hospital admission...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28412956/management-of-suspected-common-bile-duct-stones-on-cholangiogram-during-same-stay-cholecystectomy-for-acute-gallstone-related-disease
#17
Sandra de Sousa, Olivier Tobler, Pouya Iranmanesh, Jean-Louis Frossard, Philippe Morel, Christian Toso
BACKGROUND: Recent data have suggested that upfront cholecystectomy should be performed even in the presence of moderately abnormal liver function tests (LFTs). As a consequence, more common bile duct (CBD) stones are discovered on intra-operative cholangiogram. We assessed the presentation and management of such patients to refine their management plan. METHODS: Adult patients (>16 years) with an acute gallstone-related disease who had undergone same-stay cholecystectomy from January 2013 to January 2015 were retrospectively assessed...
April 17, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28409373/a-novel-method-of-self-pulling-and-latter-transected-delta-shaped-billroth-i-anastomosis-in-totally-laparoscopic-distal-gastrectomy
#18
Jun Hong, Ya-Ping Wang, Jian Wang, Yi-Bing Bei, Lu-Chun Hua, Han-Kun Hao
BACKGROUND: We developed a modified delta-shaped gastroduodenostomy technique in totally laparoscopic distal gastrectomy. This novel technique, which effectively reduces the required quantity of linear stapler [1-3], was named as self-pulling and latter transected delta-shaped anastomosis (Delta SPLT) [4]. METHODS: Delta SPLT was performed on 15 patients with stage cT1-2 antral cancer. We ligated the duodenum with a rope instead of transecting it and used the ligature rope to pull the duodenum during the whole progress of gastroduodenostomy...
April 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28408987/saving-from-unnecessary-pancreaticoduodenectomy-brunner-s-gland-hamartoma-case-report-on-a-rare-duodenal-lesion-and-exhaustive-literature-review
#19
Andrea Peloso, Jacopo Viganò, Alessandro Vanoli, Tommaso Dominioni, Sandro Zonta, Dario Bugada, Carlo Maria Bianchi, Francesco Calabrese, Ilaria Benzoni, Marcello Maestri, Paolo Dionigi, Lorenzo Cobianchi
INTRODUCTION: Brunner's gland hamartoma (BGH) is an infrequently encountered, benign, polypoid proliferation of Brunner's glands. Usually these lesions are asymptomatic, just only occasionally presenting with duodenal obstruction or bleeding signs and mimicking a tumoral lesion. CASE PRESENTATION: A 72-year-old male, referred for recurrent vomiting and epigastralgia, was investigated and all preoperative findings were suggestive of a tumour of the duodenum. During the scheduled pancreaticoduodenectomy a mass, resultant to a polyp, was palpatory felt inside the duodenum and then successfully and completely resected through a duodenotomy avoiding surgical overtreatment and connected postoperative morbidities...
May 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28408781/inflammatory-bowel-disease-affects-density-of-nitrergic-nerve-fibers-in-the-mucosal-layer-of-the-canine-gastrointestinal-tract
#20
Andrzej Rychlik, Slawomir Gonkowski, Marcin Nowicki, Jaroslaw Calka
The objective of this study was to determine the effect of inflammatory bowel disease (IBD) on the density of nitrergic nerve fibers in the mucosal layer of different sections of the gastrointestinal tract of dogs. Twenty-eight German shepherd hybrid dogs of both sexes, weighing from 15 to 25 kg and aged 6 to 10 y, were studied. The dogs were divided into 4 groups with 7 animals in each group: healthy animals, as well as dogs suffering from mild, moderate, and severe IBD. Immunoreactivity to neuronal isoform of nitric oxide synthase, which is a marker of nitrergic neurons, in samples of the mucosal layer in the duodenum, jejunum, and descending colon was studied using the single immunofluorescence method and the number of nerve fibers was evaluated in each observation field...
April 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
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