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https://www.readbyqxmd.com/read/28647710/perforated-duodenal-diverticulum-a-rare-complication-in-a-common-condition
#1
Cláudio Branco, Teresa Carneiro, Dina Luis, António Gomes
The authors present a rare case of perforated duodenal diverticulum diagnosed in an 80-year-old Caucasian woman with vomiting and abdominal pain localised to the epigastrium. CT scan showed thickening of the second portion of the duodenum with retroperitoneal fat stranding and perihepatic free fluid, with a presumptive diagnosis of a duodenal perforation. A laparotomy was performed which showed a perforated diverticulum in the second portion of the duodenum. A diverticulectomy with single-layer closure was performed, without complications...
June 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28647101/the-role-of-hypertriglyceridemia-for-acute-kidney-injury-in-the-course-of-acute-pancreatitis-and-an-animal-model
#2
Congye Wu, Lei Zou, Shujing Shi, Zhihui Tong, Xiao Shen, Dongliang Yang, Lu Ke, Weiqin Li, Jieshou Li
OBJECTIVE: The aim of this study was to investigate the role of hypertriglyceridemia for acute kidney injury (AKI) in the course of acute pancreatitis. METHODS: Patients with acute pancreatitis were retrospectively divided into four groups according to admission triglyceride: normal group, mild HTG group, moderate HTG group and severe HTG group. Clinical characteristics were compared among these groups. Wild type (WT) mice and Human ApoC III transgenic (ApoCIIItg) mice were used in the next animal experiments...
June 12, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28646342/a-case-of-malignant-peritoneal-mesothelioma-suggesting-the-utility-of-combining-double-contrast-radiography-and-endoscopy-with-computed-tomography-for-diagnosis
#3
Hirokazu Saito, Shota Hasuda, Jiro Nasu, Mitsuhiko Kitaoka, Ikuo Matsushita
A 68-year-old woman presented with abdominal pain, weight loss, and vomiting. Enhanced computed tomography (CT) showed slightly increased density in the mesentery and edema of the third portion of the duodenum and proximal jejunum. Little ascites, but no primary lesion, lymph node metastases, or distant metastases, were observed. Endoscopic findings included erythema and edema in the distal duodenum and proximal jejunum without epithelial lesions. Double-contrast radiography revealed transverse ridging with convergence, suggesting a serosal lesion...
June 23, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28641471/evaluation-of-immunomodulatory-effects-of-zearalenone-in-mice
#4
Mohammad Rafiqul Islam, Jong Won Kim, Yoon-Seok Roh, Jong-Hoon Kim, Han Kang Min, Hyung-Joo Kwon, Chae Woong Lim, Bumseok Kim
Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by Fusarium species. The toxicity of ZEA has been evaluated for reproductive and developmental effects; however, there is little evidence about its acute toxicity or general immunotoxicity. In the present study, immune regulatory functions were investigated in mice that had been exposed to ZEA (5 or 20 mg/kg BW) daily for 14 days. Results showed that sub-populations of CD4(+), CD8(+) and CD11c(+) cells in the spleen and CD4(+), CD8(+) and F4/80(+) cells in the mesenteric lymph nodes (MLN) of ZEA (20 mg/kg)-exposed hosts were decreased compared to those in the control mice...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28637224/impact-of-a-macleaya-cordata-derived-alkaloid-extract-on-necrotic-enteritis-in-broilers
#5
G D Xue, S B Wu, M Choct, A Pastor, T Steiner, R A Swick
Necrotic enteritis (NE) causes significant economic losses in the broiler chicken industry, especially in birds raised without in-feed antibiotics. A standardized blend of plant-derived isoquinoline alkaloids (IQA) derived from Macleaya cordata has shown to have anti-inflammatory potency and promoted animal productivity. This study investigated the effects of IQA supplementation on broiler chickens under NE challenge. A 2 × 2 factorial arrangement of treatments was employed with factors: NE challenge (no or yes), and additives (no additive or IQA at 0...
June 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/28631500/pancreatic-%C3%AE-cell-survival-and-proliferation-are-promoted-by-protein-kinase-g-type-i%C3%AE-and-downstream-regulation-of-akt-foxo1
#6
Janica C Wong, Van Vo, Priyatham Gorjala, Ronald R Fiscus
Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our studies have shown that low/physiological-level nitric oxide selectively activates protein kinase G type Iα isoform, promoting cytoprotective/pro-cell-survival effects in many cell types. In bone marrow-derived stromal/mesenchymal stem cells, protein kinase G type Iα mediates autocrine effects of nitric oxide and atrial natriuretic peptide, promoting DNA-synthesis/proliferation and cell survival...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28627493/parasitic-infections-in-the-east-asian-finless-porpoise-neophocaena-asiaeorientalis-sunameri-living-off-the-chinese-yellow-bohai-sea-coast
#7
X L Wan, J S Zheng, W X Li, X Y Zeng, J W Yang, Y J Hao, D Wang
Parasitic disease is among the major causes of health problems in marine mammals. However, little information on parasitic species composition and infection levels in finless porpoises (Neophocaena spp.) is available. In this study, we report the first systematic survey on parasitic infections in the East Asian finless porpoise N. asiaeorientalis sunameri (EAFP) living off the Chinese Yellow/Bohai Sea coast. Using both morphological and molecular methods, 5 parasitic helminths were identified: Campula oblonga in the liver and pancreas; Synthesium seymouri in the pyloric stomach and duodenum ampulla; Anisakis pegreffii in the forestomach, main stomach, and esophagus; Halocercus sp...
June 19, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28627054/effect-of-moringa-oleifera-leaf-powder-supplementation-on-growth-performance-and-intestinal-morphology-in-broiler-chickens
#8
I Khan, H Zaneb, S Masood, M S Yousaf, H F Rehman, H Rehman
Due to public health hazards of subtherapeutic use of antibiotics in poultry feed, there is a need for alternatives. Moringa oleifera is a phytobiotic, which is reported to possess antimicrobial and immuno-modulatory properties. This study aimed to investigate effects of M. oleifera leaf powder (MOLP) supplementation on growth performance and intestinal microarchitecture of broiler chickens. Day-old broiler chicks (n = 100) were randomly divided into five groups with four replicates each having five birds...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28626176/gastroduodenal-intussusception-with-a-gastric-gastrointestinal-stromal-tumor-treated-by-endoscopic-submucosal-dissection
#9
Kenji Yamauchi, Masaya Iwamuro, Eiji Ishii, Makoto Narita, Nobuto Hirata, Hiroyuki Okada
A 95-year-old Japanese woman presented to our hospital with intermittent vomiting and several episodes of melena. Abdominal computed tomography revealed intussusception of the gastric tumor into the duodenum. After endoscopic reduction, endoscopic ultrasonography identified a hypoechogenic lesion limited to the submucosal layer. Endoscopic resection was performed as a localized treatment for the prevention of recurrent gastroduodenal intussusception. To our knowledge, there have been no other reports describing a gastric gastrointestinal stromal tumor presenting with gastroduodenal intussusception and treated using an endoscopic submucosal dissection technique...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28623416/identifying-intestinal-malrotation-on-magnetic-resonance-examinations-ordered-for-unrelated-indications
#10
Jill S Fay, Victoria Chernyak, Benjamin H Taragin
BACKGROUND: Anatomical imaging findings indicating normal bowel rotation can be identified on cross-sectional imaging, including magnetic resonance imaging (MRI) performed for non-related indications. OBJECTIVE: The goal of our study was to assess whether non-targeted MRI can accurately assess intestinal malrotation. MATERIALS AND METHODS: Four anatomical landmarks were assessed on MRIs of the chest, spine or abdomen performed from January 2006 to June 2014, on patients who also had upper gastrointestinal series (UGI) performed within 10 years of the MRI date: 1) retroperitoneal duodenum, 2) left upper quadrant duodenojejunal junction, 3) superior mesenteric artery to the left of the superior mesenteric vein, and 4) right lower quadrant cecum...
June 16, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28621952/gastrointestinal-and-systemic-disposition-of-diclofenac-under-fasted-and-fed-state-conditions-supporting-the-evaluation-of-in-vitro-predictive-tools
#11
Jens Van Den Abeele, Ronald Schilderink, FElix Schneider, Raf Mols, Mans Minekus, Werner Weitschies, Joachim Brouwers, Jan Tack, Patrick Augustijns
This study aimed to gain further insight into the gastrointestinal disposition of the weakly acidic BCS Class II drug diclofenac and the implications for systemic drug exposure in humans under fasted and fed state conditions. For this purpose, gastrointestinal and blood samples were collected from healthy volunteers after oral intake of a commercially available tablet of the potassium salt of diclofenac (i.e. Cataflam®) in different prandial states. Subsequently, these in vivo data served as a reference for the evaluation of in vitro tools with different levels of complexity, i...
June 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28620729/subchronic-arsenism-disorders-mrna-expression-of-cytokines-and-immunoglobulins-in-the-intestinal-tract-of-the-cock
#12
Hongjing Zhao, Yu Wang, Zixin Liu, Juanjuan Liu, Yuan Xue, Mingwei Xing
Provision of feed containing arsenic may cause intestinal flora imbalance and consequently, the dysfunction of immunological protection of the cock. To understand the intricate tuning of immune responses in the intestinal tract elicited by subchronic arsenism, a cock model (1-day-old Hy-line cocks) was established by subjecting cocks to different environmentally relevant concentrations of arsenic in the diet for 90 days. Intestinal cytokine and immunoglobulin (Ig) messenger RNA (mRNA) expression levels were determined using real-time PCR on days 30, 60, and 90...
June 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28620271/glutamine-ameliorates-mucosal-damage-caused-by-immune-responses-to-duck-plague-virus
#13
Yuanyuan Zhang, Lili Zhao, Yan Zhou, Chenxi Diao, Lingxia Han, Niu Yinjie, Shengwang Liu, Hongyan Chen
The immune-releasing effects of L-glutamine (Gln) supplementation in duck plague virus (DPV)-infected ducklings were evaluated in 120 seven-day-old ducklings that were divided into 8 groups. The ducklings in control and DPV, 0.5Gln and DPV + 0.5Gln, 1.0Gln and DPV + 1.0Gln, and 2.0Gln and DPV + 2.0Gln received 0, 0.5, 1.0, and 2.0 g of Gln/kg feed/d by gastric perfusion, respectively. Then, the ducklings in control to 2.0Gln were injected with 0.2 mL of phosphate-buffered saline, while those in DPV to DPV + 2...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28619969/tension-enterothorax-and-hepatothorax-due-to-a-diaphragmatic-hernia-successful-emergency-repair-of-a-life-threatening-condition
#14
Eirini Martinou, Piers Gatenby
A 70-year-old female patient presented with acute severe respiratory distress at a district general hospital. Medical history included type 2 diabetes, recurrent pulmonary embolisms and pre-existing diaphragmatic hernia containing part of the liver. Despite initial treatment with steroid inhalers, her clinical picture rapidly deteriorated requiring emergency intubation and positive pressure ventilation. Imaging investigations revealed tension enterothorax and hepatothorax with tracheal deviation. The patient was transferred and underwent an emergency laparotomy at the Regional Oesophagogastric Unit...
June 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28619193/protein-losing-enteropathy-in-patients-with-congenital-heart-disease
#15
Maxim Itkin, David A Piccoli, Gregory Nadolski, Jack Rychik, Aaron DeWitt, Erin Pinto, Jonathan Rome, Yoav Dori
BACKGROUND: Protein-losing enteropathy (PLE), characterized by loss of proteins in the intestine, is a devastating complication in patients with congenital heart disease. The cause of PLE is unknown, but lymphatic involvement has been suspected. OBJECTIVES: The authors evaluated the use of lymphangiographic imaging and liver lymphatic embolization as a treatment for PLE. METHODS: This was a single-center, retrospective review of imaging and interventions used in 8 consecutive patients with liver lymphatic embolization and congenital heart disease with elevated central venous pressure complicated by PLE...
June 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28616401/recent-advancements-in-stent-therapy-in-patients-with-malignant-gastroduodenal-outlet-obstruction
#16
REVIEW
Hironari Kato, Koichiro Tsutsumi, Hiroyuki Okada
Gastric outlet obstruction (GOO) is one of severe comorbidities caused by many kinds of malignant diseases and is associated with not only degradation of patients' quality of life but also mortality. Although surgical bypass is one of the main therapies for malignant GOO, it is often difficult to perform in end-stage patients. The deployment of self-expandable metallic stents (SEMSs) has recently become a viable alternative to surgical bypass for malignant GOO. This technique is less invasive and more effective, particularly in patients with poor prognoses...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28615831/species-diversity-of-the-genus-thelohanellus-kudo-1933-myxozoa-bivalvulida-parasitizing-fishes-in-indian-subcontinent
#17
REVIEW
Harpreet Kaur, Ranjeet Singh, Anu Katoch, Rajni Attri, Shoaib Ali Dar, Aditya Gupta
A synopsis of 52 nominal species of the genus Thelohanellus Kudo, 1933 reported to infect freshwater fishes in India is presented. These species infect various organs such as gills, fins, scales, skin, muscles, gall bladder, kidney etc. The diagnostic features of the genus include tear-shaped myxospores with smooth shell valves and single polar capsule. The members are histozoic in their nature of parasitism infecting fresh water fishes. The present manuscript is aimed to compile the list of reported species in India along with essential information on morphometrics of vegetative stage, host, organ preference and pathogenic effects if any...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28609372/pancreatic-polypeptide-cell-proliferation-in-the-pancreas-and-duodenum-coexisting-in-a-patient-with-pancreatic-adenocarcinoma-treated-with-a-glp-1-analog
#18
Geoffrey A Talmon, J David Wren, Christophe L Nguyen, Parviz M Pour
A partial pancreaticogastrodudenectomy was performed on a 66-year old man with type 2 diabetes mellitus because of an invasive, moderately differentiated adenocarcinoma in the head of the pancreas. In the adjacent grossly normal tissue of the uncinate process, there was a massive proliferation of pancreatic polypeptide (PP) cells confined to this region and showed invasive pattern. Strikingly, in the heaped area of his duodenum, there was a strikingly large number of PP, glucagon, a few insulin cells in a mini-islet-like patterns composed of glucagon and insulin cells...
July 2017: Pancreas
https://www.readbyqxmd.com/read/28608533/effect-of-cereal-straw-and-alfalfa-hay-diet-on-amino-acid-profile-of-gastrointestinal-digesta-in-lactating-dairy-cows
#19
B Wang, Y Tu, L S Jiang, J X Liu
This study was conducted to evaluate the effects of replacing alfalfa hay with rice straw (RS) or corn stover (CS) on amino acid (AA) profiles of gastrointestinal digesta in lactating cows. Eighteen lactating dairy cows were randomly assigned to one of three groups (n = 6) and fed identical concentrate and corn silage with different forages on dry matter basis: (i) 23% alfalfa hay and 7% Chinese wild rye hay (AH); (ii) 30% CS; and (iii) 30% RS. After the 14-week feeding, a total of 18 cows were slaughtered to collect digesta from four representative organs, including rumen, omasum, duodenum and jejunum...
June 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28603033/in-vivo-analysis-of-supersaturation-precipitation-absorption-behavior-after-oral-administration-of-pioglitazone-hydrochloride-salt-determinant-site-of-oral-absorption
#20
Yusuke Tanaka, Masahisa Sugihara, Ayaka Kawakami, So Imai, Takafumi Itou, Hirokazu Murase, Kazunori Saiki, Satoshi Kasaoka, Hiroshi Yoshikawa
The purpose of this study was to evaluate in vivo supersaturation/precipitation/absorption behavior in the gastrointestinal (GI) tract based on the luminal concentration-time profiles after oral administration of pioglitazone (PG, a highly permeable lipophilic base) and its hydrochloride salt (PG-HCl) to rats. In the in vitro precipitation experiment in the classic closed system, while the supersaturation was stable in the simulated gastric condition, PG drastically precipitated in the simulated intestinal condition, particularly at a higher initial degree of supersaturation...
June 9, 2017: European Journal of Pharmaceutical Sciences
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