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https://www.readbyqxmd.com/read/28644509/comparative-transcriptomic-analysis-of-two-important-life-stages-of-angiostrongylus-cantonensis-fifth-stage-larvae-and-female-adults
#1
Liang Yu, Binbin Cao, Ying Long, Meks Tukayo, Chonglv Feng, Wenzhen Fang, Damin Luo
The mechanisms involved in the fast growth of Angiostrongylus cantonensis from fifth-stage larvae (L5) to female adults and how L5 breaks through the blood-brain barrier in a permissive host remain unclear. In this work, we compared the transcriptomes of these two life stages to identify the main factors involved in the rapid growth and transition to adulthood. RNA samples from the two stages were sequenced and assembled de novo. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of 1,346 differentially expressed genes between L5 and female adults was then undertaken...
April 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28639361/experiences-and-needs-of-relatives-of-people-with-dementia-in-acute-hospitals-a-meta-synthesis-of-qualitative-studies
#2
REVIEW
Melanie Burgstaller, Hanna Mayer, Cornel Schiess, Susi Saxer
AIMS AND OBJECTIVES: The purpose of this meta-synthesis was to present an in-depth analysis of existing qualitative literature concerning experiences and needs of the relatives of patients with dementia in hospitals. BACKGROUND: Relatives are an important resource for the care of patients with dementia in hospitals. They provide necessary information about the patient and can support the patient's care. Simultaneously, they are themselves vulnerable, having specific needs and experiences...
June 21, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28630077/what-are-the-primary-limitations-in-b-cell-affinity-maturation-and-how-much-affinity-maturation-can-we-drive-with-vaccination-breaking-through-immunity-s-glass-ceiling
#3
Garnett Kelsoe, Barton F Haynes
A key goal of HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bnAbs) targeted to the vulnerable regions of the HIV envelope. BnAbs develop over time in ∼50% of HIV-1-infected individuals. However, to date, no vaccines have induced bnAbs and few or none of these vaccine-elicited HIV-1 antibodies carry the high frequencies of V(D)J mutations characteristic of bnAbs. Do the high frequencies of mutations characteristic of naturally induced bnAbs represent a fundamental barrier to the induction of bnAbs by vaccines? Recent studies suggest that high frequencies of V(D)J mutations can be achieved by serial vaccination strategies...
June 19, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28629208/breaking-through-the-multi-mesa-channel-width-limited-of-normally-off-gan-hemts-through-modulation-of-the-via-hole-length
#4
Cheng-Yen Chien, Wen-Hsin Wu, Yao-Hong You, Jun-Huei Lin, Chia-Yu Lee, Wen-Ching Hsu, Chieh-Hsiung Kuan, Ray-Ming Lin
We present new normally off GaN high-electron-mobility transistors (HEMTs) that overcome the typical limitations in multi-mesa-channel (MMC) width through modulation of the via-hole-length to regulate the charge neutrality screen effect. We have prepared enhancement-mode (E-mode) GaN HEMTs having widths of up to 300 nm, based on an enhanced surface pinning effect. E-mode GaN HEMTs having MMC structures and widths as well as via-hole-lengths of 100 nm/2 μm and 300 nm/6 μm, respectively, exhibited positive threshold voltages (V th) of 0...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28625156/heteroduplex-cleavage-assay-for-screening-of-probable-zygosities-resulting-from-crispr-mutations-in-diploid-single-cell-lines
#5
Kyle D Luttgeharm, Kit-Sum Wong, Steve Siembieda
The most common gene editing methods, such as CRISPR, involve random repair of an induced double-stranded DNA break through the non-homologous end joining (NHEJ) repair pathway, resulting in small insertions/deletions. In diploid cells, these mutations can take on one of three zygosities: monoallelic, diallelic heterozygous, or diallelic homozygous. While many advances have been made in CRISPR delivery systems and gene editing efficiency, little work has been done to streamline detection of gene editing events...
June 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28623092/ctip-ctp1-sae2-molecular-form-fit-for-function
#6
REVIEW
Sara N Andres, R Scott Williams
Vertebrate CtIP, and its fission yeast (Ctp1), budding yeast (Sae2) and plant (Com1) orthologs have emerged as key regulatory molecules in cellular responses to DNA double strand breaks (DSBs). By modulating the nucleolytic 5'-3' resection activity of the Mre11/Rad50/Nbs1 (MRN) DSB repair processing and signaling complex, CtIP/Ctp1/Sae2/Com1 is integral to the channeling of DNA double strand breaks through DSB repair by homologous recombination (HR). Nearly two decades since its discovery, emerging new data are defining the molecular underpinnings for CtIP DSB repair regulatory activities...
June 9, 2017: DNA Repair
https://www.readbyqxmd.com/read/28582977/sorption-of-poly-and-perfluoroalkyl-substances-pfass-relevant-to-aqueous-film-forming-foam-afff-impacted-groundwater-by-biochars-and-activated-carbon
#7
Xin Xiao, Bridget A Ulrich, Baoliang Chen, Christopher P Higgins
Despite growing concerns about human exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS), other poly- and perfluoroalkyl substances (PFASs) derived from aqueous film-forming foams (AFFFs) have garnered little attention. While these other PFASs may also be present in AFFF-impacted drinking water, their removal by conventional drinking-water treatment is poorly understood. This study compared the removal of 30 PFASs, including 13 recently discovered PFASs, from an AFFF-impacted drinking water using carbonaceous sorbents (i...
June 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28531371/wing-1-of-protein-hop2-is-as-important-as-helix-3-in-dna-binding-by-md-simulation
#8
Hem Moktan, Donghua H Zhou
The repair of programmed DNA double-strand breaks through recombination is required for proper association and disjunction of the meiotic homologous chromosomes. Meiosis-specific protein HOP2 plays essential roles in recombination by promoting recombinase activities. The N-terminal domain of HOP2 interacts with DNA through helix 3 (H3) and wing 1 (W1). Mutations in wing 1 (Y65A/K67A/Q68A) slightly weakened the binding but mutations in helices 2 and 3 (Q30A/K44A/K49A) nearly abolished the binding. To better understand such differential effects at atomic level, molecular dynamics simulations were employed...
June 8, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28514120/mouth-development
#9
REVIEW
Justin Chen, Laura A Jacox, Francesca Saldanha, Hazel Sive
A mouth is present in all animals, and comprises an opening from the outside into the oral cavity and the beginnings of the digestive tract to allow eating. This review focuses on the earliest steps in mouth formation. In the first half, we conclude that the mouth arose once during evolution. In all animals, the mouth forms from ectoderm and endoderm. A direct association of oral ectoderm and digestive endoderm is present even in triploblastic animals, and in chordates, this region is known as the extreme anterior domain (EAD)...
May 17, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28504628/-the-current-global-tuberculosis-state
#10
Christian Wejse, Troels Lillebæk, Ole Kirk, Pernille Ravn, Isik Somuncu Johansen, Åse Bengård Andersen
Despite an increase in the total number of tuberculosis (TB) patients globally, positive trends in reduction of prevalence and mortality are observed. However, high numbers of drug-resistant cases are threatening this trend. Multidrug-resistant and extensively resistant cases constitute an increasing challenge in many parts of the world also within the European region - especially in former Sovjet Republic nations. Point-of-care test systems potentially replacing microscopy and urine antigen detection systems are currently launched in many TB-high endemic countries improving TB detection rates...
May 15, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28451178/janus-second-order-nonlinear-optical-dendrimers-their-controllable-molecular-topology-and-corresponding-largely-enhanced-performance
#11
Runli Tang, Shengmin Zhou, Ziyao Cheng, Gui Yu, Qian Peng, Huiyi Zeng, Guocong Guo, Qianqian Li, Zhen Li
A new type of Janus dendrimers, consisting of two different side dendrons with the dipole orientation of the second-order nonlinear optical (NLO) chromophore moieties partially in a non-centrosymmetric direction, was intelligently designed and synthesized in order to enhance the macroscopic NLO performance and break through the limitation of NLO efficiency in the current molecular topological structure of azo chromophore-based polymers. This kind of Janus dendritic structure was constructed by the combination of convergent and divergent methods, with the utilization of a powerful "click chemistry reaction"...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28448229/breaking-through-the-glass-ceiling-consumers-in-mental-health-organisations-hierarchies
#12
Brett Scholz, Julia Bocking, Brenda Happell
Contemporary mental health policies call for consumers to be engaged in all levels of mental health service planning, implementation, and delivery. Critical approaches to traditional healthcare hierarchies can effectively challenge barriers to better engagement with consumers in mental health organisations. This qualitative exploratory study analyses how particular strategies for consumer leadership facilitate or hinder relationships between consumers and mental health services, and how these strategies influence hierarchical structures...
May 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28442438/dorsal-fin-development-in-flounder-paralichthys-olivaceus-bud-formation-and-its-cellular-origin
#13
Jie Chen, Xiaoyu Liu, Xiaohua Yao, Fei Gao, Baolong Bao
The development of the median fin has not been investigated extensively in teleosts, although in other fishes it has been proposed that it involves the same genetic programs operating in the paired appendages. Adult median fins develop from the larval bud; therefore an investigation of fin bud formation and its cellular origin is essential to understanding the maturation mechanisms. In Paralichthys olivaceus, skeletogenesis proceeds from an anterior to posterior direction providing a good opportunity to study the formation of dorsal fin bud...
April 22, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/28438966/mediation-of-movement-induced-breakthrough-cancer-pain-by-ib4-binding-nociceptors-in-rats
#14
Joshua Havelin, Ian Imbert, Devki Sukhtankar, Bethany Remeniuk, Ian Pelletier, Jonathan Gentry, Alec Okun, Timothy Tiutan, Frank Porreca, Tamara E King
Cancer-induced bone pain is characterized by moderate to severe ongoing pain that commonly requires the use of opiates. Even when ongoing pain is well controlled, patients can suffer breakthrough pain (BTP), episodic severe pain that "breaks through" the medication. We developed a novel model of cancer-induced BTP using female rats with mammary adenocarcinoma cells sealed within the tibia. We demonstrated previously that rats with bone cancer learn to prefer a context paired with saphenous nerve block to elicit pain relief (i...
May 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28429768/reassembling-embryos-in-vitro-from-component-stem-cells
#15
Caroline Kubaczka, George Q Daley
Researchers at the University of Cambridge, UK have succeeded in reconstructing mouse embryos by combining pluripotent embryonic and multipotent trophoblast stem cells in a 3D scaffold; the study from the laboratory of Professor Zernicka-Goetz, recently published in Science, provides a break-through tool to probe early mammalian development outside the uterus. Achieving a similar feat with human cells might necessitate reconsideration of the 14-day rule as a limitation of such research.
April 21, 2017: Cell Research
https://www.readbyqxmd.com/read/28423385/guidelines-for-the-management-of-diabetic-macular-edema-by-the-european-society-of-retina-specialists-euretina
#16
Ursula Schmidt-Erfurth, Jose Garcia-Arumi, Francesco Bandello, Karina Berg, Usha Chakravarthy, Bianca S Gerendas, Jost Jonas, Michael Larsen, Ramin Tadayoni, Anat Loewenstein
Diabetic retinal disease is envisioned to become the plague of the coming decades with a steep increase of worldwide diabetes incidence followed by a substantial rise in retinal disease. Improvements in diagnostic and therapeutic care have to cope with this dilemma in a clinically and socioeconomically efficient manner. Laser treatment has found a less destructive competitor in pharmacological treatments. As a consequence of recent rigorous clinical trials, laser photocoagulation is no longer recommended for the treatment of diabetic macular edema (DME), and anti-vascular endothelial growth factor therapy has emerged as first-line therapy...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28402720/insulin-like-growth-factor-binding-protein-related-protein-1-inhibit-retinal-neovascularization-in-the-mouse-model-of-oxygen-induced-retinopathy
#17
Ping Zhang, Hong Wang, Hui Cao, Xun Xu, Tao Sun
PURPOSE: To explore the inhibitory effect of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) on retinal angiogenesis and its underlying molecular mechanisms in the mouse model of oxygen-induced retinopathy (OIR). METHODS: C57BL/6J mice were classified into three groups as control group, OIR nonintervention group, and OIR intervention group. Postnatal day 12 (P12) mice in OIR intervention group were received recombinant mouse IGFBP-rP1 (50, 100, and 200 ng/mL) intravitreal injection...
April 12, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28382834/psychedelic-research-in-australia-breaking-through-the-stigma
#18
Prashanth Puspanathan
No abstract text is available yet for this article.
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28372419/precisely-synchronous-and-cascadable-multi-channel-arbitrary-waveform-generator
#19
Ke Liu, Shulin Tian, Guangkun Guo, Yindong Xiao
The output bandwidth and the capability to generate multiple analog outputs with accurately adjustable relative phase are important specifications of arbitrary waveform generator (AWG). To increase the output bandwidth, AWG with a multi-memory paralleled direct digital synthesizer structure (DDS) was proposed to break through operating speed limitations of memory and field programmable gate array. But this structure does complicate synchronization of the analog outputs. This paper proposes a structure for synchronization of the outputs of multi-channel high speed AWG that generates arbitrary waveforms using a multi-memory paralleled DDS...
March 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28370971/top-down-approach-is-possible-strategy-for-predicting-break-through-futis-and-renal-scars-in-infants
#20
Shina Kawai, Takahiro Kanai, Taiju Hyuga, Shigeru Nakamura, Jun Aoyagi, Takane Ito, Takashi Saito, Jun Odaka, Rieko Furukawa, Toshinori Aihara, Hideo Nakai
BACKGROUND: Several reports have mainly examined whether acute-phase technetium-99m dimercaptosuccinic acid (DMSA) scintigraphy can detect vesicoureteral reflux (VUR) and recommend acute-phase DMSA scintigraphy for initial imaging in children with febrile urinary tract infections (fUTIs). Recently, it has been emphasized the importance of identifying patients who have risks of recurrent fUTIs (r-fUTIs). To clarify the effectiveness of DMSA scintigraphy for predicting r-fUTIs in infants, we investigated the relationship between the defects on DMSA scintigraphy and r- fUTIs...
March 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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