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https://www.readbyqxmd.com/read/28918072/development-of-a-duplex-semi-nested-pcr-assay-for-detection-of-classical-goose-parvovirus-and-novel-goose-parvovirus-related-virus-in-sick-or-dead-ducks-with-short-beak-and-dwarfism-syndrome
#1
Pengfei Li, Ruihua Zhang, Junhao Chen, Dapeng Sun, Jingjing Lan, Shaoli Lin, Shasha Song, Zhijing Xie, Shijin Jiang
Duck short beak and dwarfism syndrome (SBDS) is an emerging infectious disease caused by a novel goose parvovirus-related virus (NGPV) in China. Until now, it remains uncertain whether the Cherry Valley ducks and mule ducks with SBDS are co-infected with classical goose parvovirus (GPV) and NGPV. In this study, a duplex semi-nested PCR assay with high specificity and sensitivity was developed for detection of the two viruses. Using the duplex PCR assay, NGPV was tested positive in all the 15 duck flocks with SBDS, whereas classical GPV was not detected in all the 133 sick and dead ducks collected from East China...
September 13, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28914618/hereditary-breast-and-ovarian-cancer-syndrome-moving-beyond-brca1-and-brca2
#2
Lien N Hoang, Blake C Gilks
The recent implementation of next generation sequencing and multigene platforms has expanded the spectrum of hereditary breast and ovarian cancer syndrome, beyond the traditional genes BRCA1 and BRCA2. A large number of other moderate penetrance genes have now been uncovered, which also play critical roles in repairing double stranded DNA breaks through the homologous recombination pathway. This review discusses the landmark discoveries of BRCA1 and BRCA2, the homologous repair pathway and new genes discovered in hereditary breast and ovarian cancer syndrome, as well as their clinicopathologic significance and implications for genetic testing...
September 13, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28913524/reassessing-sers-enhancement-factors-using-thermodynamics-to-drive-substrate-design
#3
J A Guicheteau, A Tripathi, E D Emmons, S D Christesen, Augustus W Fountain
Over the past 40 years fundamental and application research into Surface-Enhanced Raman Scattering (SERS) has been explored by academia, industry, and government laboratories. To date however, SERS has achieved little commercial success as an analytical technique. Researchers are tackling a variety of paths to help break through the commercial barrier by addressing the reproducibility in both the SERS substrates and SERS signals as well as continuing to explore the underlying mechanisms. To this end, investigators use a variety of methodologies, typically studying strongly binding analytes such as aromatic thiols and azarenes, and report SERS enhancement factor calculations...
September 15, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28903635/nothing-changes-really-why-women-who-break-through-the-glass-ceiling-end-up-reinforcing-it
#4
Klea Faniko, Naomi Ellemers, Belle Derks, Fabio Lorenzi-Cioldi
Two correlational studies conducted in Switzerland ( N = 222) and Albania ( N = 156) explained the opposition of female managers to gender quotas by examining the origins and consequences of the "Queen Bee (QB)-phenomenon," whereby women who have been successful in male-dominated organizations do not support the advancement of junior women. Results disconfirm previous accounts of the QB-phenomenon as indicating competitiveness among women. Instead, the tendency of women managers to consider themselves as different from other women, and their opposition to gender quotas, emerged when junior women were addressed but not when they considered their direct competitors, other women managers...
May 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28898656/seed-dormancy-and-germination
#5
Steven Penfield
Reproduction is a critical time in plant life history. Therefore, genes affecting seed dormancy and germination are among those under strongest selection in natural plant populations. Germination terminates seed dispersal and thus influences the location and timing of plant growth. After seed shedding, germination can be prevented by a property known as seed dormancy. In practise, seeds are rarely either dormant or non-dormant, but seeds whose dormancy-inducing pathways are activated to higher levels will germinate in an ever-narrower range of environments...
September 11, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28881597/tgfbeta-and-mirna-regulation-in-familial-and-sporadic-breast-cancer
#6
Katia Danza, Simona De Summa, Rosamaria Pinto, Brunella Pilato, Orazio Palumbo, Massimo Carella, Ondina Popescu, Maria Digennaro, Rosanna Lacalamita, Stefania Tommasi
The term 'BRCAness' was introduced to identify sporadic malignant tumors sharing characteristics similar to those germline BRCA-related. Among all mechanisms attributable to BRCA1 expression silencing, a major role has been assigned to microRNAs. MicroRNAs role in familial and sporadic breast cancer has been explored but few data are available about microRNAs involvement in homologous recombination repair control in these breast cancer subgroups. Our aim was to seek microRNAs associated to pathways underlying DNA repair dysfunction in breast cancer according to a family history of the disease...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876216/you-re-deaf-breaking-through-myths-for-effective-therapeutic-practice
#7
Teresa Crowe
Most mental health practitioners provide services to hearing clients and may be unprepared when a deaf individual requests services. The purpose of this article is to explore commonly held stereotypes and myths about deaf people and to provide guidance to clinicians who encounter deaf clients in their practices. Myths and stereotypes can affect the way clinicians perceive their clients' needs. This can lead to miscommunication, misunderstanding, and misinformation which can harm the therapeutic relationship, thus making effective therapy unattainable...
September 6, 2017: Journal of Social Work in Disability & Rehabilitation
https://www.readbyqxmd.com/read/28818534/endoscopic-treatment-of-vesicoureteral-reflux-in-infants-can-we-do-it-and-should-we-do-it
#8
Sara Fuentes, Andrés Gómez-Fraile, Isabel Carrillo-Arroyo, Cristina Tordable-Ojeda, Daniel Cabezalí-Barbancho
Objective To evaluate the outcomes of endoscopic treatment of vesicoureteral reflux (VUR) performed on infants, and to discuss the possible role of this approach in selected cases. Material and Methods A retrospective analysis was conducted on the patients that underwent endoscopic injection of a bulking substance for VUR in our institution, and a comparison made with patients treated as infants and those treated later in life. Results A total 463 ureteric units were included (296 children), of which 47 of them were patients less than one year of age (infants, INF group), with the remaining 416 being included in a second group (children, CHL)...
August 14, 2017: Urology
https://www.readbyqxmd.com/read/28816924/treatment-of-premenstrual-breakthrough-of-depression-with-adjunctive-oral-contraceptive-pills-compared-with-placebo
#9
Whitney Peters, Marlene P Freeman, Semmie Kim, Lee S Cohen, Hadine Joffe
PURPOSE/BACKGROUND: Two-thirds of women with depressive disorders report reemergence of depression premenstrually, or premenstrual exacerbation (PME), despite effective treatment of the underlying mood disorder during the remainder of the cycle. There is a paucity of studies that rigorously assess treatments targeting PME. Open-label data suggest that augmentation of antidepressants with the oral contraceptive pill (OCP) drospirenone and ethinyl estradiol (DRSP/EE) improves depressive symptoms that break through treatment premenstrually...
August 15, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28813600/discovery-of-enhanced-magnetoelectric-coupling-through-electric-field-control-of-two-magnon-scattering-within-distorted-nanostructures
#10
Xu Xue, Ziyao Zhou, Guohua Dong, Mengmeng Feng, Yijun Zhang, Shishun Zhao, Zhongqiang Hu, Wei Ren, Zuo-Guang Ye, Yaohua Liu, Ming Liu
Electric field control of dynamic spin interactions is promising to break through the limitation of the magnetostatic interaction based magnetoelectric (ME) effect. In this work, electric field control of the two-magnon scattering (TMS) effect excited by in-plane lattice rotation has been demonstrated in a La0.7Sr0.3MnO3 (LSMO)/Pb(Mn2/3Nb1/3)-PbTiO3 (PMN-PT) (011) multiferroic heterostructure. Compared with the conventional strain-mediated ME effect, a giant enhancement of ME effect up to 950% at the TMS critical angle is precisely determined by angular resolution of the ferromagnetic resonance (FMR) measurement...
August 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28807365/-the-breakthrough-of-personalized-medicine-new-hopes-and-new-challenges
#11
REVIEW
Ronan Flippot, Christophe Massard, Edouard Auclin, David Azria, Héloïse Bourien, Philippe Rochigneux, Antoine Schernberg, Loïc Verlingue, Lara Zafrani, Stéphane Vignot
The development of personalized medicine in oncology is based on biomarkers that help select populations for more efficient and less toxic therapies. The onset of molecular biology led to new paradigms in drug development, with efficacy data reported in early clinical trials and accelerated approvals. Multiple clinical trials, including SHIVA, SAFIR-01 and MOSCATO-01, have been developed to evaluate the interest of treatment decision-making based on tumor molecular profiling, with the ambition to replace historical clinical and pathological classifications...
August 11, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28777786/breaking-through-how-researchers-are-gaining-entry-into-barricaded-bacteria
#12
Shraddha Chakradhar
No abstract text is available yet for this article.
August 4, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28763932/-the-progress-and-prospect-of-application-of-genetic-testing-technology-based-gene-detection-technology-in-the-diagnosis-and-treatment-of-hereditary-cancer
#13
J X He, Y F Jiang
Hereditary cancer is caused by specific pathogenic gene mutations. Early detection and early intervention are the most effective ways to prevent and control hereditary cancer. High-throughput sequencing based genetic testing technology (NGS) breaks through the restrictions of pedigree analysis, provide a convenient and efficient method to detect and diagnose hereditary cancer. Here, we introduce the mechanism of hereditary cancer, summarize, discuss and prospect the application of NGS and other genetic tests in the diagnosis of hereditary retinoblastoma, hereditary breast and ovarian cancer syndrome, hereditary colorectal cancer and other complex and rare hereditary tumors...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28730412/gns4-a-novel-allele-of-dwarf11-regulates-grain-number-and-grain-size-in-a-high-yield-rice-variety
#14
Yong Zhou, Yajun Tao, Jinyan Zhu, Jun Miao, Jun Liu, Yanhua Liu, Chuandeng Yi, Zefeng Yang, Zhiyun Gong, Guohua Liang
BACKGROUND: Rice plays an extremely important role in food safety because it feeds more than half of the world's population. Rice grain yield depends on biomass and the harvest index. An important strategy to break through the rice grain yield ceiling is to increase the biological yield. Therefore, genes associated with organ size are important targets for rice breeding. RESULTS: We characterized a rice mutant gns4 (grain number and size on chromosome 4) with reduced organ size, fewer grains per panicle, and smaller grains compared with those of WT...
December 2017: Rice
https://www.readbyqxmd.com/read/28718794/brs1-function-in-facilitating-lateral-root-emergence-in-arabidopsis
#15
Qian Deng, Xue Wang, Dongzhi Zhang, Xiaoming Wang, Cuizhu Feng, Shengbao Xu
The BRS1 (BRI1 Suppressor 1) gene encodes a serine carboxypeptidase that plays a critical role in the brassinosteroid signaling pathway. However, its specific biological function remains unclear. In this study, the developmental role of BRS1 was investigated in Arabidopsis thaliana. We found that overexpressing BRS1 resulted in significantly more lateral roots in different Arabidopsis ecotypes (WS2 and Col-0) and in brassinosteroid mutants (bri1-5 and det2-28). Further research showed that BRS1 facilitates the process whereby lateral root primordia break through the endodermis, cortex, and epidermis...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28712102/precision-medicine-in-metastatic-colorectal-cancer-relevant-carcinogenic-pathways-and-targets-part-2-approaches-beyond-first-line-therapy-and-novel-biologic-agents-under-investigation
#16
REVIEW
Benjamin A Weinberg, Marion L Hartley, Mohamed E Salem
A frequent quandary for oncologists is the selection of chemotherapy and biologic therapy for patients with metastatic colorectal cancer in second-line and higher treatment settings. While not approved by the US Food and Drug Administration (FDA) in the first-line setting, the vascular endothelial growth factor (VEGF)-targeting agents ziv-aflibercept and ramucirumab are appropriate treatment options in the second-line setting, as is continuation of first-line bevacizumab. Tumor RAS mutational status is helpful to determine which patients may benefit from epidermal growth factor receptor (EGFR)-directed therapies, and other novel biomarkers (BRAF, HER2, and mismatch repair deficiency) allow us to select patients who may benefit from biologic therapies that are FDA-approved for other malignancies...
July 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28685959/targeting-cholesterol-transport-in-circulating-melanoma-cells-to-inhibit-metastasis
#17
Yu-Chi Chen, Raghavendra Gowda, Raymond K Newswanger, Patrick Leibich, Barry Fell, Gerson Rosenberg, Gavin P Robertson
Despite recent break throughs in targeted- and immune-based therapies, rapid development of drug resistance remains a hurdle for the long-term treatment of melanoma patients. Targeting metastatically spreading circulating tumor cells (CTCs) may provide an additional approach to manage melanoma. This study investigates whether targeting cholesterol transport in melanoma CTCs can retard metastasis development. Nanolipolee-007, the liposomal form of leelamine, reduced melanoma metastasis in both a novel in vitro flow system mimicking the circulating system and in experimental as well as spontaneous animal metastasis models, irrespective of the BRAF mutational status of the CTCs...
July 7, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28651204/iron-tannin-framework-complex-modified-pes-ultrafiltration-membranes-with-enhanced-filtration-performance-and-fouling-resistance
#18
Xiaofeng Fang, Jiansheng Li, Xin Li, Shunlong Pan, Xiuyun Sun, Jinyou Shen, Weiqing Han, Lianjun Wang, Bart Van der Bruggen
In this work, an iron-tannin-framework (ITF) complex was introduced to a poly (ether sulfone) (PES) casting solution as a hydrophilic additive to fabricate ITF/PES ultrafiltration (UF) membranes via non-solvent-induced phase separation (NIPS). The structure and performance of the PES membranes with ITF concentrations ranging from 0 to 0.9wt.% were systematically investigated by scanning electron microscopy, water contact angle, permeability, protein rejection and fouling resistance measurements. The results indicate that the pore structure and surface properties of PES UF membranes can be regulated by incorporating the ITF complex...
November 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28644509/comparative-transcriptomic-analysis-of-two-important-life-stages-of-angiostrongylus-cantonensis-fifth-stage-larvae-and-female-adults
#19
Liang Yu, Binbin Cao, Ying Long, Meks Tukayo, Chonglv Feng, Wenzhen Fang, Damin Luo
The mechanisms involved in the fast growth of Angiostrongylus cantonensis from fifth-stage larvae (L5) to female adults and how L5 breaks through the blood-brain barrier in a permissive host remain unclear. In this work, we compared the transcriptomes of these two life stages to identify the main factors involved in the rapid growth and transition to adulthood. RNA samples from the two stages were sequenced and assembled de novo. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of 1,346 differentially expressed genes between L5 and female adults was then undertaken...
April 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28639361/experiences-and-needs-of-relatives-of-people-with-dementia-in-acute-hospitals-a-meta-synthesis-of-qualitative-studies
#20
REVIEW
Melanie Burgstaller, Hanna Mayer, Cornel Schiess, Susi Saxer
AIMS AND OBJECTIVES: The purpose of this meta-synthesis was to present an in-depth analysis of existing qualitative literature concerning experiences and needs of the relatives of patients with dementia in hospitals. BACKGROUND: Relatives are an important resource for the care of patients with dementia in hospitals. They provide necessary information about the patient and can support the patient's care. Simultaneously, they are themselves vulnerable, having specific needs and experiences...
June 21, 2017: Journal of Clinical Nursing
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