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https://www.readbyqxmd.com/read/28316197/-inhibitory-effect-of-insulin-like-growth-factor-binding-protein-related-protein-1-on-retinal-angiogenesis-via-erk-signaling-pathway
#1
P Zhang, H Wang, H Cao, X Xu, T Sun
Objective: To explore the inhibitory effect of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a novel anti-angiogenic factor, on retinal angiogenesis and its underlying molecular mechanisms. Methods: Experimental study. C57BL/6J mice were classified into three groups: control group (n=24), oxygen-induced retinopathy (OIR) non-intervention group (n=24) and OIR intervention group (n=72). The OIR mouse model was established using improved Smith's methods (n= 96). Twelve-day-old mice in the OIR intervention group were randomly assigned into three groups receiving intravitreal injection of recombinant mouse IGFBP-rP1 (50 μg/L, 100 μg/L and 200 μg/L, respectively)...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28306260/a-computational-study-on-the-mechanisms-of-multiple-complexation-of-co-and-isonitrile-ligand-to-boron
#2
Xuejiao J Gao, Xingfa Gao
The recent experimental realization of compound Tripp-B(CO)2 (denoted as 2a), where Tripp is 2,6-di(2,4,6-triisopropylphenyl)-phenyl), breaks through the conventional knowledge that only transition metals can bind more than one CO to form multicarbonyl adducts. Compound 2a is stable in air but liberates CO under light. The B-CO bonds of 2a are considered to be similar to donor-acceptor bonds of transition metal complexes. To address the formation mechanism and chemical bonding of this novel type of boron compounds, we present a density functional theory study on the formation and photolysis of 2a and the similar compounds...
March 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28268508/extraction-of-medically-interpretable-features-for-classification-of-malignancy-in-breast-thermography
#3
Himanshu Madhu, Siva Teja Kakileti, Krithika Venkataramani, Susmija Jabbireddy
Thermography, with high-resolution cameras, is being re-investigated as a possible breast cancer screening imaging modality, as it does not have the harmful radiation effects of mammography. This paper focuses on automatic extraction of medically interpretable non-vascular thermal features. We design these features to differentiate malignancy from different non-malignancy conditions, including hormone sensitive tissues and certain benign conditions, which have an increased thermal response. These features increase the specificity for breast cancer screening, which had been a long known problem in thermographic screening, while retaining high sensitivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28252656/quantum-spin-hall-insulators-in-centrosymmetric-thin-films-composed-from-topologically-trivial-bitei-trilayers
#4
I A Nechaev, S V Eremeev, E E Krasovskii, P M Echenique, E V Chulkov
The quantum spin Hall insulators predicted ten years ago and now experimentally observed are instrumental for a break- through in nanoelectronics due to non-dissipative spin-polarized electron transport through their edges. For this transport to persist at normal conditions, the insulators should possess a sufficiently large band gap in a stable topological phase. Here, we theoretically show that quantum spin Hall insulators can be realized in ultra-thin films constructed from a trivial band insulator with strong spin-orbit coupling...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251767/fluorooxoborates-beryllium-free-deep-ultraviolet-nonlinear-optical-materials-without-layered-growth
#5
Bingbing Zhang, Guoqiang Shi, Zhihua Yang, Fangfang Zhang, Shilie Pan
Deep-ultraviolet nonlinear optical (DUV NLO) crystals are the key materials to extend the output range of solid-state lasers to below 200 nm. The only practical material KBe2 BO3 F2 suffers high toxicity through beryllium and strong layered growth. Herein, we propose a beryllium-free material design and synthesis strategy for DUV NLO materials. Introducing the (BO3 F)(4-) , (BO2 F2 )(3-) , and (BOF3 )(2-) groups in borates could break through the fixed 3D B-O network that would produce a larger birefringence without layering and simultaneously keep a short cutoff edge down to DUV...
March 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28250319/the-current-state-and-future-development-of-epigenetic-toxicology
#6
Katsuhide Igarashi, Maky Ideta-Otsuka, Minoru Narita
 Epigenetics has drawn much attention as a mechanism of transcriptional regulation involving modifications to genomic DNA and histone, without changes to nucleotide sequences. Epigenetics is related to various biological phenomena. We defined one of these phenomena as "epigenetic toxicity", in which chemicals affect epigenetic regulation and result in undesirable effects on living organisms. We then detailed the importance of epigenetics and the need for intensive research. Epigenetics is a mechanism that might explain the long-lasting effects of chemicals in an organism, and the formation of a predisposition to various diseases...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28248562/breaking-through-to-the-other-side-a-resident-explores-the-benefits-of-time-limited-psychodynamic-therapy-for-patients-with-schizophrenia
#7
Zoë Thomas
This article recounts the case of a patient with schizophrenia engaged in time-limited psychodynamic psychotherapy with a psychiatry resident-the first case history of its type to the author's knowledge. This patient suffered from chronically debilitating schizophrenia with persistent positive and negative symptoms at the time of treatment, despite usual psychiatric management. He benefited significantly from 18 weekly sessions of weekly dynamic therapy, achieving symptom reduction, increased social involvement, and improved functioning-gains that were sustained at 9-month follow-up...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/28242625/zmym3-regulates-brca1-localization-at-damaged-chromatin-to-promote-dna-repair
#8
Justin W C Leung, Nodar Makharashvili, Poonam Agarwal, Li-Ya Chiu, Renaud Pourpre, Michael B Cammarata, Joe R Cannon, Alana Sherker, Daniel Durocher, Jennifer S Brodbelt, Tanya T Paull, Kyle M Miller
Chromatin connects DNA damage response factors to sites of damaged DNA to promote the signaling and repair of DNA lesions. The histone H2A variants H2AX, H2AZ, and macroH2A represent key chromatin constituents that facilitate DNA repair. Through proteomic screening of these variants, we identified ZMYM3 (zinc finger, myeloproliferative, and mental retardation-type 3) as a chromatin-interacting protein that promotes DNA repair by homologous recombination (HR). ZMYM3 is recruited to DNA double-strand breaks through bivalent interactions with both histone and DNA components of the nucleosome...
February 27, 2017: Genes & Development
https://www.readbyqxmd.com/read/28226682/extraction-of-medically-interpretable-features-for-classification-of-malignancy-in-breast-thermography
#9
Himanshu Madhu, Siva Teja Kakileti, Krithika Venkataramani, Susmija Jabbireddy, Himanshu Madhu, Siva Teja Kakileti, Krithika Venkataramani, Susmija Jabbireddy, Susmija Jabbireddy, Krithika Venkataramani, Siva Teja Kakileti, Himanshu Madhu
Thermography, with high-resolution cameras, is being re-investigated as a possible breast cancer screening imaging modality, as it does not have the harmful radiation effects of mammography. This paper focuses on automatic extraction of medically interpretable non-vascular thermal features. We design these features to differentiate malignancy from different non-malignancy conditions, including hormone sensitive tissues and certain benign conditions, which have an increased thermal response. These features increase the specificity for breast cancer screening, which had been a long known problem in thermographic screening, while retaining high sensitivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28207184/an-im-penetrable-shield-how-the-tumor-microenvironment-protects-cancer-stem-cells
#10
Theresa Relation, Massimo Dominici, Edwin M Horwitz
Cancer stem cells (CSCs) are defined by their unlimited self-renewal ability and their capacity to initiate and maintain malignancy, traits that are not found in most cells that comprise the tumor. Although current cancer treatments successfully reduce tumor burden, the tumor will likely recur unless CSCs are effectively eradicated. This challenge is made greater by the protective impact of the tumor microenvironment (TME), consisting of infiltrating immune cells, endothelial cells, extracellular matrix, and signaling molecules...
February 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28195227/non-blind-acoustic-invisibility-by-dual-layers-of-homogeneous-single-negative-media
#11
He Gao, Yi-Fan Zhu, Xu-Dong Fan, Bin Liang, Jing Yang, Jian-Chun Cheng
Non-blind invisibility cloaks allowing the concealed object to sense the outside world have great application potentials such as in high-precision sensing or underwater camouflage. However the existing designs based on coordinate transformation techniques need complicated spatially-varying negative index or intricate multi-layered configurations, substantially increasing the difficulty in practical realization. Here we report on the non-blind acoustic invisibility for a circular object in free space with simple distribution of cloak parameters...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192927/improving-the-resolution-of-3d-printed-molds-for-microfluidics-by-iterative-casting-shrinkage-cycles
#12
Miao Sun, Yanbo Xie, Jihong Zhu, Jun Li, Jan C T Eijkel
Breaking through technical barriers and cost reduction are critical issues for the development of microfluidic devices, and both rely greatly on the innovation of fabrication techniques and use of new materials. The application of 3D printing definitely accelerated the prototyping of microfluidic chips by its versatility and functionality. However, the resolution of existing 3D printing techniques is still far below that of lithography, which makes it difficult to work on the scale of single cells and near impossible for single molecule work...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191487/preparation-of-protein-containing-extracts-from-microbiota-rich-intestinal-contents
#13
Patricia Dillenburg-Pilla, Carlos R Zárate-Bladés, Phyllis B Silver, Reiko Horai, Rachel R Caspi
The contribution of microbiota in regulating multiple physiological and pathological host responses has been studied intensively in recent years. Evidence suggests that commensal microbiota can directly modulate different populations of cells of the immune system (e.g., Ivanov et al., 2008; Atarashi et al., 2011). Recently, we showed that protein extracts from gut commensal microbiota can activate retina-specific T cells, allowing these autoreactive T cells to then break through the blood-retinal barrier and trigger autoimmune uveitis in the recipient (Horai et al...
September 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28159920/tgfbeta-and-mirna-regulation-in-familial-and-sporadic-breast-cancer
#14
Katia Danza, Simona De Summa, Rosamaria Pinto, Brunella Pilato, Orazio Palumbo, Massimo Carella, Ondina Popescu, Maria Digennaro, Rosanna Lacalamita, Stefania Tommasi
The term 'BRCAness' was introduced to identify sporadic malignant tumors sharing characteristics similar to those germline BRCA-related. Among all mechanisms attributable to BRCA1 expression silencing, a major role has been assigned to microRNAs. MicroRNAs role in familial and sporadic breast cancer has been explored but few data are available about microRNAs involvement in homologous recombination repair control in these breast cancer subgroups. Our aim was to seek microRNAs associated to pathways underlying DNA repair dysfunction in breast cancer according to a family history of the disease...
January 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28150833/kinetically-controlled-synthesis-of-nanoporous-au-and-its-enhanced-electrocatalytic-activity-for-glucose-based-biofuel-cells
#15
Man Xu, Yongming Sui, Guanjun Xiao, Xinyi Yang, Yingjin Wei, Bo Zou
Nanoporous gold (NPG) structures, which possess abundant high-index facets, kinks, and steps, have been demonstrated as effective catalysts for the glucose electrooxidation in biofuel cells. Herein, we designed surface-clean NPG structures with high-index facets by a trisodium citrate (Na3Cit) self-initiated reduction of chloroauric acid (HAuCl4) in a water-ice bath followed by a kinetically controlled self-assembly manner. This strategy breaks through the traditional trisodium citrate thermal-reducing chloroauric acid approach where solutions are required to heat to a certain temperature for the reaction to initiate...
February 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28145210/the-nhs-could-learn-from-inspiring-leaders-like-barack-obama
#16
Yvonne Coghill
I remember November 2008 like it was yesterday. I was the lead for the NHS Leadership Academy's national Breaking Through programme for black and minority ethnic staff, and recall being at our annual conference bursting with pride at the news that Barack Obama had been elected president of the United States.
February 1, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28145122/breaking-through-the-solid-liquid-processability-barrier-thermal-conductivity-and-rheology-in-hybrid-graphene-graphite-polymer-composites
#17
Maxim Varenik, Roey Nadiv, Idan Levy, Gleb Vasilyev, Oren Regev
Thermal conductivity (TC) enhancement of an insulating polymer matrix at low filler concentration is possible through the loading of a high aspect ratio, thermally conductive single filler. Unfortunately, the dispersion of high-aspect-ratio particles greatly influences the rheological behavior of the polymer host at relatively low volume fractions, which makes further polymer processing or mixing difficult. A possible remedy is using two (hybrid) fillers, differing in their aspect ratios: (1) a plate-like filler, which sharply increases both viscosity and TC, and (2) an isotropic filler, which gradually increases these properties...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28139712/sounds-can-boost-the-awareness-of-visual-events-through-attention-without-cross-modal-integration
#18
Márta Szabina Pápai, Salvador Soto-Faraco
Cross-modal interactions can lead to enhancement of visual perception, even for visual events below awareness. However, the underlying mechanism is still unclear. Can purely bottom-up cross-modal integration break through the threshold of awareness? We used a binocular rivalry paradigm to measure perceptual switches after brief flashes or sounds which, sometimes, co-occurred. When flashes at the suppressed eye coincided with sounds, perceptual switches occurred the earliest. Yet, contrary to the hypothesis of cross-modal integration, this facilitation never surpassed the assumption of probability summation of independent sensory signals...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28137900/rare-presentation-of-brodie-s-abscess-in-the-acromion-process-and-the-value-of-the-penumbra-sign
#19
Jelle Gorter, Kyrill Rykov, Pieter Ott, Jos J A M van Raay
A 17-year-old male patient presented with a swelling on his right shoulder 1 week after a fall. MRI revealed a superficial fluid collection of the acromion and trapezius muscle, with slight enhancement of the wall. The swelling burst open spontaneously after failed conservative therapy and was treated with surgical drainage and antibiotics. Tissue cultures showed a Staphylococcus aureus 1 year later, he presented with local red discolouration and a recurrent painful swelling that fluctuated at palpation...
January 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28132860/mantle-cell-lymphoma-with-a-novel-t-11-12-q13-p11-2-a-proposed-alternative-mechanism-of-ccnd1-upregulation
#20
Joshua R Menke, George Vasmatzis, Stephen Murphy, Lin Yang, David M Menke, Han W Tun, Rebecca L King, Stephanie A Smoley, Rhett P Ketterling, William R Sukov
Mantle cell lymphoma (MCL) is typically characterized by t(11;14) which places the IGH@ enhancer elements upstream of CCND1. This fusion results in upregulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untranslated region (UTR) of the CCND1 gene can result in a truncated mRNA transcript that is more stable and associated with more aggressive disease. We identified a case of MCL showing cyclin D1 overexpression by immunohistochemistry and a t(11;12)(q13;p11...
January 26, 2017: Human Pathology
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