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https://www.readbyqxmd.com/read/29347334/sequence-selection-by-dynamical-symmetry-breaking-in-an-autocatalytic-binary-polymer-model
#1
Harold Fellermann, Shinpei Tanaka, Steen Rasmussen
Template-directed replication of nucleic acids is at the essence of all living beings and a major milestone for any origin of life scenario. We present an idealized model of prebiotic sequence replication, where binary polymers act as templates for their autocatalytic replication, thereby serving as each others reactants and products in an intertwined molecular ecology. Our model demonstrates how autocatalysis alters the qualitative and quantitative system dynamics in counterintuitive ways. Most notably, numerical simulations reveal a very strong intrinsic selection mechanism that favors the appearance of a few population structures with highly ordered and repetitive sequence patterns when starting from a pool of monomers...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345386/quinoline-flanked-diketopyrrolopyrrole-copolymers-breaking-through-electron-mobility-over-6-cm2-v-1-s-1-in-flexible-thin-film-devices
#2
Zhenjie Ni, Huanli Dong, Hanlin Wang, Shang Ding, Ye Zou, Qiang Zhao, Yonggang Zhen, Feng Liu, Lang Jiang, Wenping Hu
Herein, the design and synthesis of novel π-extended quinoline-flanked diketopyrrolopyrrole (DPP) [abbreviated as QDPP] motifs and corresponding copolymers named PQDPP-T and PQDPP-2FT for high performing n-type organic field-effect transistors (OFETs) in flexible organic thin film devices are reported. Serving as DPP-flankers in backbones, quinoline is found to effectively tune copolymer optoelectric properties. Compared with TDPP and pyridine-flanked DPP (PyDPP) analogs, widened bandgaps and strengthened electron deficiency are achieved...
January 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29343295/cytotoxic-t-lymphocytes-from-cattle-sharing-the-same-mhc-class-i-haplotype-and-immunized-with-live-theileria-parva-sporozoites-differ-in-antigenic-specificity
#3
Lucilla Steinaa, Nicholas Svitek, Elias Awino, Rosemary Saya, Philip Toye
OBJECTIVES: The objective of this study was to assess whether cytotoxic T cells (CTL) generated by the live vaccine, known as "ITM Muguga cocktail", which is used for the cattle disease East Cost fever (ECF) in Sub-Saharan Africa, showed a broad reactivity against many different strains of the causative parasite Theileria parva. We also assessed whether immune responses were similar in cattle expressing the same MHC class I haplotypes. RESULTS: The antigenic specificity of CTL from MHC class I-matched cattle vaccinated with the Muguga cocktail were different...
January 17, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29341057/-suicidal-adolescents-can-benefit-from-family-group-conferences
#4
J A Koudstaal, G Schout, R H B Simons-Van Alphen, R R J M Vermeiren
A risk factor among suicidal adolescents is generally their inability to form and maintain relationships with other people. In the case that we investigated, the technique known as Family Group Conference (FGC) was used successfully to break through the adolescent's passivity and social isolation. The FGC also helped to alter the adolescent's conviction of being a burden to relatives, friends and other people. The results are in line with additional studies that used FGC with other target groups. This case study suggests that FGC is a promising type of intervention that can reduce the passivity and isolation of suicidal adolescents, strengthening their relationships and boosting a feeling of belonging...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29340274/breaking-through-restricting-bottleneck-for-better-asthma-control
#5
Ding Zhu, Chao Zhang, Huahao Shen, Songmin Ying
No abstract text is available yet for this article.
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29324224/good-bug-bad-bug-breaking-through-microbial-stereotypes
#6
Mihai Cirstea, Nina Radisavljevic, B Brett Finlay
Our expanding knowledge of microbial mechanisms is challenging the notion of "good" versus "bad" microbes and encouraging a better understanding of their roles in various contexts before their widespread therapeutic and clinical application. The intestinal microbe Akkermansia muciniphila, a promising probiotic with an emerging cautionary tale, best highlights this challenge.
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29300763/food-words-distract-the-hungry-evidence-of-involuntary-semantic-processing-of-task-irrelevant-but-biologically-relevant-unexpected-auditory-words
#7
Fabrice B R Parmentier, Antonia P Pacheco-Unguetti, Sara Valero
Rare changes in a stream of otherwise repeated task-irrelevant sounds break through selective attention and disrupt performance in an unrelated visual task by triggering shifts of attention to and from the deviant sound (deviance distraction). Evidence indicates that the involuntary orientation of attention to unexpected sounds is followed by their semantic processing. However, past demonstrations relied on tasks in which the meaning of the deviant sounds overlapped with features of the primary task. Here we examine whether such processing is observed when no such overlap is present but sounds carry some relevance to the participants' biological need to eat when hungry...
2018: PloS One
https://www.readbyqxmd.com/read/29275612/-prevention-and-treatment-of-electrical-burn-injury-much-progresses-achieved-yet-further-efforts-still-needed
#8
W G Xie
Electrical burn injury is very common, including electrical contact burn, electrical arc burn, and lightning burn, etc. Electrical burn patients account for 0.04 to 5 percent of all burn victims in the developed countries, while it hit up to 27 percent in the developing countries, much more than the global average of 4.5 percent. Historical and recent data have shown that the electrical burn injuries in China, either for the case number, the proportion of burn patients in hospital, or the population incidence per year, are much higher than those of the developed countries and the global average...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29245687/a-new-species-of-i-chiridota-i-echinodermata-holothuroidea-apodida-chiridotidae-from-japan-and-first-record-of-i-c-rigida-i-from-japan
#9
Yusuke Yamana, Hayato Tanaka
A new apodid sea cucumber, Chiridota impatiens sp. nov., is described from the intertidal zone of Okinawa, Japan, and C. rigida Semper, 1867 is also described from the intertidal zone of Wakayama, as new to Japan. C. impatiens sp. nov. is approximately 60-70 mm, with 12 tentacles and 4-7 pairs of digits per tentacle, red or reddish brown in living specimens. The tentacles contain curved rod ossicles, with spinous processes and many branches in C. rigida, however, in C. impatiens sp. nov., the curved rod ossicles are crescent-shaped, sometimes distally, with spinous processes and rarely a few branches on the circumference...
October 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/29231845/maillard-proteomics-opening-new-pages
#10
REVIEW
Alena Soboleva, Rico Schmidt, Maria Vikhnina, Tatiana Grishina, Andrej Frolov
Protein glycation is a ubiquitous non-enzymatic post-translational modification, formed by reaction of protein amino and guanidino groups with carbonyl compounds, presumably reducing sugars and α-dicarbonyls. Resulting advanced glycation end products (AGEs) represent a highly heterogeneous group of compounds, deleterious in mammals due to their pro-inflammatory effect, and impact in pathogenesis of diabetes mellitus, Alzheimer's disease and ageing. The body of information on the mechanisms and pathways of AGE formation, acquired during the last decades, clearly indicates a certain site-specificity of glycation...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29194866/break-through-bleeding-in-relation-to-pharmacokinetics-of-factor-viii-in-paediatric-patients-with-severe-haemophilia-a
#11
X Cheng, P Li, Z Chen, N Zhang, Y Zhen, L Zhao, X Wang, R Wu
INTRODUCTION: As the pharmacokinetics (PK) of factor VIII (FVIII) is individualized in children with haemophilia A (HA), PK parameters may be indicators of patients' bleeding phenotype and instruction for their personalized replacement program. AIM: The aim of this study was to investigate the possible relationship between PK/FVIII level and bleeding frequency in Chinese paediatric patients with severe (HA). METHODS: A total of 24 patients were enrolled in Beijing Children's Hospital from February to October 2015, all of whom were given 50 IU/kg of FVIII concentrates after a 72-hours washout period...
December 1, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29194419/the-interplay-between-natural-killer-cells-and-human-herpesvirus-6
#12
REVIEW
Eva Eliassen, Dario Di Luca, Roberta Rizzo, Isabel Barao
Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Natural killer (NK) cells are lymphocytes that, along with neutrophils and monocytes/macrophages, participate in the critical innate immune response during viral infections, but can also mediate the antigen-specific memory responses generally associated with adaptive immunity...
December 1, 2017: Viruses
https://www.readbyqxmd.com/read/29191859/swim-and-fly-escape-strategy-in-neustonic-and-planktonic-copepods
#13
Leonid Svetlichny, Poul S Larsen, Thomas Kiørboe
Copepods may respond to predators by powerful escape jumps that in some surface dwelling forms may propel the copepod out of the water. We studied the kinematics and energetics of submerged and out-of-water jumps of two neustonic pontellid Anomalocera patersoni and Pontella mediterranea and one pelagic calanoid copepod Calanus helgolandicus (euxinus). We show that jumping out of the water does not happen just by inertia gained during the copepod's acceleration underwater, but also requires the force generated by the thoracic limbs when breaking through the water's surface to overcome surface tension, drag, and gravity...
November 30, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29190294/cngcs-break-through-a-rice-cyclic-nucleotide-gated-channel-paves-the-way-for-pollen-tube-growth
#14
Wolfgang Moeder, Keiko Yoshioka
No abstract text is available yet for this article.
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29178088/-education-and-training-for-laparoscopic-gastrointestinal-surgery-our-10-years-experience-in-nanfang-hospital
#15
Guoxin Li, Jiang Yu, Yanfeng Hu, Hao Liu, Xinhua Chen
The laparoscopic surgery for gastrointestinal cancer developed slowly and was at a crossroad of choice at the beginning of the 21st century. However, the team of laparoscopic surgery in Nanfang Hospital was keenly conscious that minimally invasive surgery (MIS) would bring new era to the treatment of gastrointestinal cancer. Therefore, our team went into the exploration of laparoscopic surgery for gastrointestinal cancer: (1) researching a series of anatomical theories for MIS; (2) lucubrating the applicable pattern of fascia and mesentery under laparoscopic view; (3) finding out the precise anatomical landmarks and surgical layers; (4) optimizing the operative strategy...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29148712/constructing-repairable-meta-structures-of-ultra-broadband-electromagnetic-absorption-from-3d-printed-patterned-shells
#16
Wei-Li Song, Zhili Zhou, Lichen Wang, Xiao-Dong Cheng, Mingji Chen, Rujie He, Hao-Sen Chen, Yazheng Yang, Daining Fang
Ultra-broadband electromagnetic absorption materials and structures are increasingly attractive for their critical role in competing to the advanced broadband electromagnetic detective systems. Mechanically soft and weak wax-based materials composites are known to be insufficient to serve for practical electromagnetic absorption applications. To break through such barriers, here we developed an innovative strategy to enable the wax-based composites as robust and repairable meta-structures by employing a 3D printed polymeric patterned shell...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29141730/keeping-abreast-of-developments-in-the-cancer-wars-a-view-from-the-front
#17
Nancy L Baenziger
Cancer somehow lends itself to military analogies, perhaps because of its status as a threat to life itself. We've declared war on cancer over several decades, viewing cancer as a cell going rogue, dividing uncontrollably, and ultimately breaking through local boundaries to spread. Less well known, but critically relevant to the health care impact of questioning authority, is the war within the breast cancer management community, among those studying molecular and cellular targets in breast cancer biology and those managing the human targets that represent cancer's toll...
November 1, 2017: Creative Nursing
https://www.readbyqxmd.com/read/29123101/symmetry-control-of-nanorod-superlattice-driven-by-a-governing-force
#18
Yujia Liang, Yong Xie, Dongxue Chen, Chuanfei Guo, Shuai Hou, Tao Wen, Fengyou Yang, Ke Deng, Xiaochun Wu, Ivan I Smalyukh, Qian Liu
Nanoparticle self-assembly promises scalable fabrication of composite materials with unique properties, but symmetry control of assembled structures remains a challenge. By introducing a governing force in the assembly process, we develop a strategy to control assembly symmetry. As a demonstration, we realize the tetragonal superlattice of octagonal gold nanorods, breaking through the only hexagonal symmetry of the superlattice so far. Surprisingly, such sparse tetragonal superstructure exhibits much higher thermostability than its close-packed hexagonal counterpart...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29047946/experimental-study-of-an-optimized-psp-ostbc-scheme-with-m-ppm-in-ultraviolet-scattering-channel-for-optical-mimo-system
#19
Dahai Han, Yanjie Gu, Min Zhang
An optimized scheme of pulse symmetrical position-orthogonal space-time block codes (PSP-OSTBC) is proposed and applied with m-pulse positions modulation (m-PPM) without the use of a complex decoding algorithm in an optical multi-input multi-output (MIMO) ultraviolet (UV) communication system. The proposed scheme breaks through the limitation of the traditional Alamouti code and is suitable for high-order m-PPM in a UV scattering channel, verified by both simulation experiments and field tests with specific parameters...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29043622/alkaline-denaturing-southern-blot-analysis-to-monitor-double-strand-break-processing
#20
Chiara Vittoria Colombo, Luca Menin, Michela Clerici
Generation of 3' single-stranded DNA (ssDNA) tails at the ends of a double-strand break (DSB) is essential to repair the break through accurate homology-mediated repair pathways. Several methods have been developed to measure ssDNA accumulation at a DSB in the budding yeast Saccharomyces cerevisiae. Here, we describe one of these assays, which is based on the inability of restriction enzymes to cleave ssDNA. Digestion of genomic DNA prepared at different time points after DSB generation leads to the formation of ssDNA fragments whose length increases as the 5' strand degradation proceeds beyond restriction sites...
2018: Methods in Molecular Biology
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