Yanpeng Tian, Yibin Liu, Yanlai Xiao, Zhongkang Li, Mingle Zhang, Liang Chen, Zhen Li, Wangchao Zhang, Zhiqiang Zhang, Desheng Kong, Li Meng, Yanfang Du, Jingkun Zhang, Jingui Gao, Xianghua Huang
BACKGROUND: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a severe congenital disorder characterized by vaginal hypoplasia caused by dysplasia of the Müllerian duct. Patients with MRKH syndrome often require nonsurgical or surgical treatment to achieve satisfactory vaginal length and sexual outcomes. The extracellular matrix has been successfully used for vaginal reconstruction. METHODS: In this study, we developed a new biological material derived from porcine vagina (acellular vaginal matrix, AVM) to reconstruct the vagina in Bama miniature pigs...
November 10, 2023: Tissue Engineering and Regenerative Medicine