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Johanne Penafiel, Amelia V Hesketh, Ori Granot, J Scott McIndoe
Electron ionization (EI) is a reliable mass spectrometric method for the analysis of the vast majority of thermally stable and volatile compounds. In direct EI-MS, the sample is placed into the probe and introduced to the source. For air- and moisture-sensitive organometallic complexes, the sample introduction step is critical. A small quantity must be briefly exposed to the atmosphere, during which time decomposition can occur. Here we present a simple tool that allows convenient analysis of air- and moisture-sensitive organometallic species by direct probe methods: a small purge-able glove chamber affixed to the front end of the mass spectrometer...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Oya Soylu Karapınar, Mustafa Özkan, Ayşe Güler Okyay, Hanifi Şahin, Kenan Serdar Dolapçıoğlu
OBJECTIVE: Retrospective analysis of cases that have undergone neovagina operation because of congenital vaginal agenesis was objected. MATERIAL AND METHODS: Seven cases applying with the complaints of primary amenorrhea or inability to have sexual intercourse were in the study. The cases were diagnosed with congenital vaginal agenesis and operated at Mustafa Kemal University Training and Research Hospital between 2011 and 2014. Vaginoplasty by the modified McIndoe method was performed in all cases...
2016: Journal of the Turkish German Gynecological Association
Eric Janusson, G Bryce McGarvey, Farhana Islam, Christine Rowan, J Scott McIndoe
A simple chemical derivatization technique was developed for electrospray ionization mass spectrometry (ESI-MS) in which thiols and disulfides may be selectively analyzed in a complex matrix and easily characterized. These reagents enhance detection of thiols and disulfides solely due to the nature of the charge-tag derivatization agent and therefore does not require an isotopically labelled substrate. The charged disulfides readily and exclusively react with thiols in a complex matrix in a short amount of time...
October 7, 2016: Analyst
Brijesh Mishra, Gaurav Janavar, Yashodhara Pradeep, Arun K Singh, Vijay Kumar, Divya N Upadhyay
Absence of vagina poses multitude of physical and psychosocial problems in woman's life. 10% of Mayer- Rokitansky-üster-Hauser (MRKH) syndrome patients with high vaginal septum and vaginal atreisa has additional issue of draining uterine cavity. MC Indoe vaginoplasty is universally acceptable and widely practiced procedure for neocolposis reconstruction. Simultaneous reconstruction of vagina with simultaneous continued uterine drainage presents surgical challenge. We offer a simple solution of creating a vaginal mould using a 10 ml disposable syringe, which enables graft application of neovaginal cavity with simultaneous protected uterine drainage per vaginum...
January 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
P J Siddall, L McIndoe, P Austin, P J Wrigley
STUDY DESIGN: The study uses a cross-sectional, group comparison, questionnaire-based design. OBJECTIVES: To determine whether spinal cord injury and pain have an impact on spiritual well-being and whether there is an association between spiritual well-being and measures of pain and psychological function. SETTING: University teaching hospital in Sydney, New South Wales, Australia. METHODS: Questionnaires evaluating pain, psychological and spiritual well-being were administered to a group of people with a spinal cord injury (n=53) and a group without spinal cord injury (n=37)...
May 31, 2016: Spinal Cord
Jayanta Chatterjee, Stephanie Howden, Srdjan Saso, Sadaf Ghaem-Maghami, Angus McIndoe, Roberto Dina
No abstract text is available yet for this article.
May 16, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
S Ali, C Sims, S Foy, A McIndoe, R Yates, T Brooke
This paper describes and discusses a review of adult special care dentistry day cases in a UK hospital over a two year period and makes recommendations for other such reviews and for practice. Dental public health competencies illustrated: oral health needs assessment and evaluation of dental health services.
March 2016: Community Dental Health
Wg Cdr Ankur Pandya
No abstract text is available yet for this article.
September 2015: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
Soumyakanta Prusty, Shobhana Krishnaswamy, Sreenivasulu Bandi, Baby Chandrika, Jingwei Luo, J Scott McIndoe, Garry S Hanan, Dillip Kumar Chand
Interlocked Coordination Rings. A series of D-shaped binuclear coordination rings are prepared by the self-assembly of two non-chelating bidentate ligands and a chosen cis-protected Pd(II) unit in 1:1:2 ratios under appropriate conditions. In their Full Paper on page 15174 ff., D. K. Chand et al. demonstrate the concentration-dependent dynamic equilibria (in water) between a given D-shaped ring and the corresponding interlocked pair of rings. The molecular species present in the equilibria are thoroughly characterized in spite of the intrinsic difficulties of such kind of systems...
October 19, 2015: Chemistry: a European Journal
Zohrab Ahmadi, Lars P E Yunker, Allen G Oliver, J Scott McIndoe
The mechanism of the Sonogashira reaction in methanol was studied in detail using pressurized sample infusion electrospray ionization mass spectrometry (PSI-ESI-MS). Several key intermediates were identified and their structures were assigned by MS/MS studies. Cationic and anionic charged-tagged substrates were employed to look into the mechanism of this reaction from variety of angles. A reverse kinetic isotope effect was observed in which the reaction rate is accelerated in deuterated solvents (kH/kD = 0...
December 21, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
Warren Ladiges, Yuji Ikeno, Laura Niedernhofer, Richard A McIndoe, Marcia A Ciol, Jerry Ritchey, Denny Liggitt
Geropathology is the study of aging and age-related lesions and diseases in the form of whole necropsies/autopsies, surgical biopsies, histology, and molecular biomarkers. It encompasses multiple subspecialties of geriatrics, anatomic pathology, molecular pathology, clinical pathology, and gerontology. In order to increase the consistency and scope of communication in the histologic and molecular pathology assessment of tissues from preclinical and clinical aging studies, a Geropathology Research Network has been established consisting of pathologists and scientists with expertise in the comparative pathology of aging, the design of aging research studies, biostatistical methods for analysis of aging data, and bioinformatics for compiling and annotating large sets of data generated from aging studies...
April 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
C R Spencer
BACKGROUND: Sir Harold Gillies, born in New Zealand, is widely considered a British icon and the father of modern plastic surgery. OBJECTIVE: This article provides an overview of his life and the circumstances which led to him laying the foundations of plastic surgery in Britain in the early twentieth century. METHODS: A hand search and review of case notes from the Gillies Archives at Queen Mary's Hospital in Sidcup, UK, where he made history, was conducted...
June 2015: Journal of Laryngology and Otology
Sylvia A Hayashida, José Maria Soares-Jr, Elaine M F Costa, Angela M da Fonseca, Gustavo A R Maciel, Berenice B Mendonça, Edmund C Baracat
OBJECTIVE: To compare two methods of neovagina construction, the Frank and McIndoe techniques, in terms of structural and biological aspects. STUDY DESIGN: A total of 55 subjects were included in this retrospective study: 43 underwent the Frank technique (FT) and 12 underwent the McIndoe technique (MT). A clinical evaluation and a comparison of the structural (color, shine, presence of hair, and histology) and biological (bacteriological, pH, and hormonal determinations) features were performed...
March 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Marcio Masashi Kajikawa, Zsuzsanna Ilona Katalin Jármy-Di Bella, Juliane Dornelas, Luciana Campanatti Crema, Cláudia Cristina Takano, Gustavo Rubino de Azevedo Focchi, Liliam Cristine Rolo, Edward Araujo Júnior, Rodrigo Aquino Castro, Manoel João Batista Castello Girão, Marair Gracio Ferreira Sartori
The aim of the study was to compare the expression of oestrogen receptor alpha (ERα) in neovaginal tissue of patients with vaginal agenesis following neovaginoplasty using regenerated, oxidised cellulose in premenopausal women. A prospective, observational case-control study was performed on eight patients with vaginal agenesis following modified Abbé-McIndoe neovaginoplasty and 10 control premenopausal women following benign gynaecologic surgery. 6F11 monoclonal antibody was used to determine ERα expression in the vaginal mucosa...
April 2015: Gynecological Endocrinology
Aubrey Rauktys, Pranay Parikh, Oz Harmanli
BACKGROUND: When conservative options such as the use of vaginal dilators fail, the McIndoe technique may be used in the surgical treatment of a foreshortened vagina. The McIndoe procedure, an approach commonly used for the treatment of vaginal agenesis, requires a mold over which a skin graft is sutured and placed inside the vagina. In most surgical descriptions, this mold is made from non-sterile foam, condoms, or gloves. Because makeshift molds can no longer be used in operating rooms owing to strict regulations, alternative methods must be employed...
January 2015: Obstetrics and Gynecology
Tyler K Trefz, Matthew A Henderson, Mikko Linnolahti, Scott Collins, J Scott McIndoe
Electrospray-ionization mass spectrometric studies of poly(methylaluminoxane) (MAO) in the presence of [Cp2 ZrMe2 ], [Cp2 ZrMe(Cl)], and [Cp2 ZrCl2 ] in fluorobenzene (PhF) solution are reported. The results demonstrate that alkylation and ionization are separate events that occur at competitive rates in a polar solvent. Furthermore, there are significant differences in ion-pair speciation that result from the use of metallocene dichloride complexes in comparison to alkylated precursors at otherwise identical Al/Zr ratios...
February 9, 2015: Chemistry: a European Journal
M Delaine, J Ohl
OBJECTIVES: This study evaluated the sexual activity and the quality of life in patients with a Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. PATIENTS AND METHODS: The study is based on a series of patients hospitalized for the treatment of MRKH syndrome in CMCO between 1997 and 2010. Through the medical reports, we recovered information about the pathology, the treatment given and the psychological support proposed to or wished by the patients. The patients also had to answer a questionnary concerning the quality of the informations they received about the treatment, the different types of supports proposed and wanted, their life as a couple and how they communicated about their disease...
December 2014: Gynécologie, Obstétrique & Fertilité
Sungwook Chun, Yeon Mee Kim, Yong-Il Ji
Mayer-Rokitansky-Kuster-Hauser syndrome (MRKHS) is characterized by vaginal agenesis with variable Müllerian duct abnormalities. We report here a case of uterine adenomyosis which developed from a hypoplastic uterus in a patient with MRKHS. A 55-year-old postmenopausal woman visited a university hospital for pelvic mass. She had underwent vaginoplasty via the McIndoe procedure for MRKHS at 15 years of age. Pelvic magnetic resonance imaging showed a 5.4 × 4.8 × 4.7 cm mass suspicious for a uterine myoma. She received total abdominal hysterectomy with bilateral salpingo-oophorectomy, and neither the cervix nor endometrium was found grossly in the surgical specimen...
December 2013: Journal of Menopausal Medicine
Pierluigi Benedetti Panici, Diana Maffucci, Simona Ceccarelli, Enrica Vescarelli, Giorgia Perniola, Ludovico Muzii, Cinzia Marchese
STUDY OBJECTIVE: To present the procedure and the results of a technique in which in vitro autologous cell cultures were used for the canal lining in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) subjected to vaginoplasty with a modified Abbè-McIndoe technique. MRKHS is a rare anomaly characterized by vaginal agenesis with variable müllerian duct abnormalities. The Abbè-McIndoe procedure is 1 of the most frequent surgical treatments adopted in these women. In the last decades, several modifications have been introduced by different authors, mostly changing the lining material, but no consensus has been reached on what material should be used for the neovagina canal wall lining...
February 2015: Journal of Minimally Invasive Gynecology
Lukasz Wojciech, Alicja Ignatowicz, Michal Seweryn, Grzegorz Rempala, Simarjot Singh Pabla, Richard A McIndoe, Pawel Kisielow, Leszek Ignatowicz
The role of the T-cell receptor (TCR) in commitment of thymocytes to regulatory CD4(+)Foxp3(+) and conventional CD4(+)Foxp3(-) T-cell lineages remains controversial. According to the prevailing view, commitment to the former lineage, in contrast to the latter, requires that high affinity TCRs bind rare class II MHC/peptide complexes presented in 'thymic niches', which could explain differences between their TCR repertoires. Here we challenge this view and show that the binding of identical TCRs to the same ubiquitously expressed MHC/peptide complex often directs thymocytes to both CD4(+) lineages, indicating that the TCR affinity does not play the instructive role, and that restricted presentation of peptides in 'thymic niches' is not necessary for selection of CD4(+)Foxp3(+) T cells...
2014: Nature Communications
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