Manjari Joshi, Robert V O'Toole, Anthony R Carlini, Joshua L Gary, William T Obremskey, Clinton K Murray, Greg Gaski, J Spence Reid, Yasmin Degani, Tara J Taylor, Susan C Collins, Yanjie Huang, Paul S Whiting, Joseph T Patterson, Olivia C Lee, Renan C Castillo
OBJECTIVE: To determine whether intrawound vancomycin changes the bacteriology of surgical site infection pathogens and investigate the emergence of antibiotic-resistant pathogens. DESIGN: Secondary analysis of phase III, prospective, randomized clinical trial. SETTING: Thirty-six US trauma centers. PATIENT SELECTION CRITERIA: Patients who became infected after fixation of tibial plateau or pilon fracture. OUTCOME MEASURES AND COMPARISONS: Pathogen types and bacterial susceptibilities as determined from routine clinical culture in the operating room...
April 1, 2024: Journal of Orthopaedic Trauma