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Alzhimers dementia

Marco Me Pagani, Alessandro Giuliani, Johanna Öberg, Fabrizio De Carli, Silvia Morbelli, Nicola Girtler, Francesca Bongioanni, Dario Arnaldi, Jennifer Accardo, Matteo Bauckneht, Andrea Chincarini, Gianmario Sambuceti, Cathrine Jonsson, Flavio Nobili
Brain connectivity has been assessed in several neurodegenerative disorders investigating the mutual correlations between pre-determined regions or nodes. The selective breakdown of brain networks during the progression from the normal aging (NA) to Alzheimer's Disease (AD) has also been observed. We implemented Independent Component Analysis (ICA) on 18F-FDG-PET data in five groups of subjects with cognitive state ranging from NA to AD dementia, including mild cognitive impairment patients not converting (ncMCI) and converting (MCI) to mild AD dementia, in order to disclose the spatial distribution of the independent components (ICs) in each cognitive state, and their accuracy in discriminating the groups...
March 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Hana Tomášková, Jitka Kühnová, Kamil Kuča
The aim of the paper is to describe asystem dynamics model applied on aprediction of the number of patients with Alzheimers disease in the EU in the future and related financial impacts. Dementia resulting from Alzheimers disease is the most widely spread type of dementia and is highly connected with the age of the person - the patient. Most people are diagnosed with Alzheimers disease when they are older than 64. The ageing of population will be an ongoing problem in the next few decades due to alow birth rate and increasing life expectancy...
2016: Ceská a Slovenská Farmacie
Solveig Tiepolt, Swen Hesse, Marianne Patt, Julia Luthardt, Matthias L Schroeter, Karl-Titus Hoffmann, David Weise, Hermann-Josef Gertz, Osama Sabri, Henryk Barthel
PURPOSE: [(18)F]FDG is a commonly used neuronal injury biomarker for early and differential diagnosis of dementia. Typically, the blood supply to the brain is closely coupled to glucose consumption. Early uptake of the Aβ tracer [(11)C]PiB on PET images is mainly determined by cerebral blood flow and shows a high correlation with [(18)F]FDG uptake. Uptake data for (18)F-labelled Aβ PET tracers are, however, scarce. We investigated the value of early PET images using the novel Aβ tracer [(18)F]FBB in the diagnosis of Alzhimers disease (AD)...
August 2016: European Journal of Nuclear Medicine and Molecular Imaging
Lokraj Subedee, R N Suresh, Jayanthi Mk, Kalabharathi Hl, Satish Am, Pushpa Vh
INTRODUCTION: Dementia is the clinical symptom of alzheimer's disease. Brain cholinesterase levels and behavioural changes are the markers for Alzheimer's disease and aluminium chloride is one causative agent for polymerization of tau protein and amyloid plaque formation in Alzheimer's disease. Effect of piper nigrum and its role in prevention of alzhimer's disease and symptoms are well linked in this study. AIM: To study the effect of piper nigrum for the prevention of alzheimer's associated histopathological, biochemical and behaviour changes in rat model...
April 2015: Journal of Clinical and Diagnostic Research: JCDR
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