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https://www.readbyqxmd.com/read/29334648/using-mass-struvite-precipitation-to-remove-recalcitrant-nutrients-and-micropollutants-from-anaerobic-digestion-dewatering-centrate
#1
M Abel-Denee, T Abbott, C Eskicioglu
The primary objective of this research was to remove recalcitrant nutrients from anaerobically digested sludge dewatering centrate. A struvite precipitation methodology is proposed where salt crystals are encouraged to ballast colloidal particles through heterogeneous nucleation and subsequent crystal growth. The secondary objective was to assess presence of micropollutants in precipitates. Four biologically unique dewatering centrates were used to test the precipitation methodology on the variety of anaerobic digester configurations that can be expected from municipal wastewater treatment plant...
January 5, 2018: Water Research
https://www.readbyqxmd.com/read/29334516/computer-based-training-in-eating-and-nutrition-facilitates-person-centered-hospital-care-a-group-concept-mapping-study
#2
Albert Westergren, Ellinor Edfors, Erika Norberg, Anna Stubbendorff, Gita Hedin, Martin Wetterstrand, Scott R Rosas, Peter Hagell
Studies have shown that computer-based training in eating and nutrition for hospital nursing staff increased the likelihood that patients at risk of undernutrition would receive nutritional interventions. This article seeks to provide understanding from the perspective of nursing staff of conceptually important areas for computer-based nutritional training, and their relative importance to nutritional care, following completion of the training. Group concept mapping, an integrated qualitative and quantitative methodology, was used to conceptualize important factors relating to the training experiences through four focus groups (n = 43), statement sorting (n = 38), and importance rating (n = 32), followed by multidimensional scaling and cluster analysis...
January 12, 2018: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29334489/association-between-arterial-stiffness-and-wave-reflection-with-subsequent-development-of-placental-mediated-diseases-during-pregnancy-findings-of-a-systematic-review-and-meta-analysis
#3
Mohamed Waseem Osman, Mintu Nath, Eamonn Breslin, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
OBJECTIVE: We present a comprehensive systematic review of published literature to examine, whether arterial stiffness and wave reflection measurements during pregnancy differed between healthy patients and patients with placental-mediated diseases including preeclampsia (PET), small for gestational age (SGA), fetal death, and placental abruption, and a quantitative assessment of the findings using the meta-analysis approach. METHODS: We searched Medline, Embase, and The Cochrane Library for studies of arterial stiffness in pregnancy, analyzed pregnancy outcomes and conducted the meta-analysis of data evaluated by trimesters of pregnancy...
January 13, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29334421/a-survey-of-tooth-morphology-teaching-methods-employed-in-the-united-kingdom-and-ireland
#4
M Lone, J P McKenna, J F Cryan, E J Downer, A Toulouse
BACKGROUND: Tooth morphology is a central component of the dental curriculum and is applicable to all dental specialities. Traditional teaching methods are being supplemented with innovative strategies to tailor teaching and accommodate the learning styles of the recent generation of students. METHODS: An online survey was compiled and distributed to the staff involved in teaching tooth morphology in the United Kingdom and Ireland to assess the importance of tooth morphology in the dentistry curriculum and the methodologies employed in teaching...
January 15, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29334416/investigating-causal-associations-between-use-of-nicotine-alcohol-caffeine-and-cannabis-a-two-sample-bidirectional-mendelian-randomization-study
#5
Karin J H Verweij, Jorien L Treur, Jacqueline M Vink
BACKGROUND AND AIMS: Epidemiological studies consistently show co-occurrence of use of different addictive substances. Whether these associations are causal or due to overlapping underlying influences remains an important question in addiction research. Methodological advances have made it possible to use published genetic associations to infer causal relationships between phenotypes. In this exploratory study, we used Mendelian randomization (MR) to examine the causality of well-established associations between nicotine, alcohol, caffeine, and cannabis use...
January 15, 2018: Addiction
https://www.readbyqxmd.com/read/29334352/the-multimorbidity-cluster-analysis-tool-identifying-combinations-and-permutations-of-multiple-chronic-diseases-using-a-record-level-computational-analysis
#6
Kathryn Nicholson, Michael Bauer, Amanda Terry, Martin Fortin, Tyler Williamson, Amardeep Thind
Multimorbidity, or the co-occurrence of multiple chronic health conditions within an individual, is an increasingly dominant presence and burden in modern health care systems.  To fully capture its complexity, further research is needed to uncover the patterns and consequences of these co-occurring health states.  As such, the Multimorbidity Cluster Analysis Tool and the accompanying Multimorbidity Cluster Analysis Toolkit have been created to allow researchers to identify distinct clusters that exist within a sample of participants or patients living with multimorbidity...
December 13, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29334347/methods-to-describe-referral-patterns-in-a-canadian-primary-care-electronic-medical-record-database-modelling-multilevel-count-data
#7
Bridget L Ryan, Joshua Shadd, Heather Maddocks, Moira Stewart, Amardeep Thind, Amanda L Terry
  A referral from a family physician (FP) to a specialist is an inflection point in the patient journey, with potential implications for clinical outcomes and health policy. Primary care electronic medical record (EMR) databases offer opportunities to examine referral patterns. Until recently, software techniques were not available to model these kinds of multi-level count data. OBJECTIVE:  To establish methodology for determining referral rates from FPs to medical specialists using the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) EMR database...
November 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29334326/predicting-the-dopamine-d2-receptor-occupancy-of-ropinirole-in-rats-using-positron-emission-tomography-and-pharmacokinetic-pharmacodynamic-modeling
#8
Chenrong Huang, Ziteng Wang, Linsheng Liu, Xiaoxue Liu, Ji Dong, Qingqing Xu, Bin Zhang, Liyan Miao
The purpose of this study was to measure dopamine D2/3 receptor occupancy (RO) as a marker of the clinical efficacy of ropinirole in rats via positron emission tomography (PET) using 18F-fallypride as the radiotracer and to explore the relationship between dopamine RO and the plasma concentration of ropinirole via pharmacokinetic-pharmacodynamic modeling. Plasma was collected from 16 rats treated with one of four doses of ropinirole. For the time-dependent study, the data of 16 rats in the 15 mg/kg dose group at four time points were averaged, and another 24 rats were divided into three dose groups (5 mg/kg, 30 mg/kg and 60 mg/kg) for the dose-dependent study; the animals were assessed via 18F-fallypride PET scans...
January 15, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29334224/diversity-oriented-approach-to-n-heterocyclic-compounds-from-%C3%AE-phenyl-%C3%AE-enamino-ester-via-a-mitsunobu-michael-reaction-sequence
#9
Hina P A Khan, Tushar Kanti Chakraborty
Herein we delineate a novel route for the diastereoselective construction of diversely substituted N-heterocyclic ring systems as valuable scaffolds for natural products and pharmaceuticals, starting from easily accessible prochiral α-phenyl-β-enamino ester. The reaction sequence relies on the unexplored reactivity of α-phenyl-β-enamino ester as a nucleophilic partner in Mitsunobu reaction to forge the N-tethered alkene-alcohol/thiol/amine intermediate which was subjected to intramolecular hetero-Michael addition reaction under mild conditions to furnish the respective N-heterocyclic compounds embedded with an exocyclic chiral center in high yields and excellent diastereoselectivities...
January 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29334170/representing-causal-knowledge-in-environmental-policy-interventions-advantages-and-opportunities-for-qualitative-influence-diagram-applications
#10
John F Carriger, Brian E Dyson, William H Benson
This article develops and explores a methodology for using qualitative influence diagrams in environmental policy and management to support decision making efforts that minimize risk and increase resiliency. Influence diagrams are representations of the conditional aspects of a problem domain. Their graphical properties are useful for structuring causal knowledge relevant to policy interventions and can be used to enhance inference and inclusivity of multiple viewpoints. Qualitative components of influence diagrams are beneficial tools for identifying and examining the interactions among the critical variables in complex policy development and implementation...
January 15, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29334168/representing-causal-knowledge-in-environmental-policy-interventions-advantages-and-opportunities-for-qualitative-influence-diagram-applications
#11
John F Carriger, Brian E Dyson, William H Benson
This article develops and explores a methodology for using qualitative influence diagrams in environmental policy and management to support decision making efforts that minimize risk and increase resiliency. Influence diagrams are representations of the conditional aspects of a problem domain. Their graphical properties are useful for structuring causal knowledge relevant to policy interventions and can be used to enhance inference and inclusivity of multiple viewpoints. Qualitative components of influence diagrams are beneficial tools for identifying and examining the interactions among the critical variables in complex policy development and implementation...
January 15, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29334159/a-gold-iii-pincer-ligand-scaffold-for-the-synthesis-of-binuclear-and-bioconjugated-complexes-synthesis-and-anticancer-potential
#12
Bertrand Benoît, Maria A O'Connell, Zöe A E Waller, Manfred Bochmann
Cyclometalated (C^N^C)Au(III) complexes bearing functionalized N-heterocyclic carbene (NHC) ligands provide a high-yielding, modular route to bioconjugated and binuclear complexes. That methodology has been applied to the synthesis of bioconjugated complexes presenting biotin and 17α-ethynylestradiol vectors, as well as to the synthesis of bimetallic Au(III)/Au(I) complexes. The in vitro antiproliferative activities of these compounds against various cancer cells lines depend on the linker length, with the longer linker being the most potent...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29333846/-food-allergy-in-children-recommendations-for-diagnosis-and-treatment
#13
(no author information available yet)
Food allergy arises from a specific immune response induced by food exposure. It is the first cause of anaphylaxis in childhood. Its prevalence increased exponentially in western countries. The proteins most frequently involved in infants are cow's milk and hen's egg; and in adults, seafood. Peanuts have the same frequency in both groups. The clinical manifestations and methodology of study are directly related to the pathophysiology of the disease. Clinical history, skin prick test, patch test, and food oral challenge are essential to arrive at a correct diagnosis, that will avoid unnecessary exclusions or exposures that carry life risk...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333689/2d-black-phosphorus-reinforced-3d-printed-scaffolds-a-stepwise-countermeasure-for-osteosarcoma
#14
Bowen Yang, Junhui Yin, Yu Chen, Shanshan Pan, Heliang Yao, Youshui Gao, Jianlin Shi
With the ever-deeper understanding of nano-bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next-generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D-printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus-driven, calcium-extracted biomineralization of the intra-scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material-guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333667/improved-electron-transport-with-reduced-contact-resistance-in-n-doped-polymer-field-effect-transistors-with-a-dimeric-dopant
#15
Rong Wang, Yikun Guo, Di Zhang, Huiqiong Zhou, Dahui Zhao, Yuan Zhang
Attaining control on charge injection properties is significant for meaningful applications of organic field-effect transistors (OFETs). Here, molecular electron-doping is applied with an air-stable dimer dopant for n-type OFETs based on (naphthalene diimide-diketopyrrolopyrrole) polymer hosts. Through investigating the doping effect on contact and transport properties, it is found that the electron transport increases in n-doped OFETs at low doping regime with remaining large on/off ratios. These favorable meliorations are reconciled by the mitigated impacts of contact resistance and interfacial traps, as well as the surface morphology exhibiting features of increased ordering...
January 15, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29333332/next-generation-tissue-engineering-of-orthopedic-soft-tissue-to-bone-interfaces
#16
Alexander J Boys, Mary Clare McCorry, Scott Rodeo, Lawrence J Bonassar, Lara A Estroff
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29333145/moving-toward-standardization-of-urine-albumin-measurements
#17
Jesse C Seegmiller, W Greg Miller, Lorin M Bachmann
Measurement of urine albumin is important for detecting and monitoring kidney disease. At the present time, measurement of urine albumin is not standardized due to the lack of a reference system, which includes both a reference measurement procedure and certified reference materials. Developing a reference system will provide a means for clinical laboratory measurement procedures to become standardized and will enable successful use of uniform clinical decision points. Currently, urine albumin results vary in excess of 40% depending on which commercially available measurement procedure is utilized for measurement...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333139/a-framework-for-an-alternatives-assessment-dashboard-for-evaluating-chemical-alternatives-applied-to-flame-retardants-for-electronic-applications
#18
Todd M Martin
The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are compared using a variety of human health effects, ecotoxicity, and physicochemical properties. Hazard profiles are completed using a variety of online sources and quantitative structure activity relationship models. In the second stage, alternatives are evaluated utilizing an exposure/risk assessment over the entire life cycle...
May 1, 2017: Clean Technologies and Environmental Policy
https://www.readbyqxmd.com/read/29333000/distributions-of-emissions-intensity-for-individual-beef-cattle-reared-on-pasture-based-production-systems
#19
G A McAuliffe, T Takahashi, R J Orr, P Harris, M R F Lee
Life Cycle Assessment (LCA) of livestock production systems is often based on inventory data for farms typical of a study region. As information on individual animals is often unavailable, livestock data may already be aggregated at the time of inventory analysis, both across individual animals and across seasons. Even though various computational tools exist to consider the effect of genetic and seasonal variabilities in livestock-originated emissions intensity, the degree to which these methods can address the bias suffered by representative animal approaches is not well-understood...
January 10, 2018: Journal of Cleaner Production
https://www.readbyqxmd.com/read/29332998/high-pressure-epr-spectroscopy-studies-of-the-e-coli-lipopolysaccharide-transport-proteins-lpta-and-lptc
#20
Kathryn M Schultz, Candice S Klug
The use of pressure is an advantageous approach to the study of protein structure and dynamics because it can shift the equilibrium populations of protein conformations toward higher energy states that are not of sufficient population to be observable at atmospheric pressure. Recently, the Hubbell group at the University of California, Los Angeles, reintroduced the application of high pressure to the study of proteins by electron paramagnetic resonance (EPR) spectroscopy. This methodology is possible using X-band EPR spectroscopy due to advances in pressure intensifiers, sample cells, and resonators...
December 2017: Applied Magnetic Resonance
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