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https://www.readbyqxmd.com/read/28743177/traditional-suburethral-sling-operations-for-urinary-incontinence-in-women
#1
REVIEW
Haroon Rehman, Carlos A Bezerra, Homero Bruschini, June D Cody, Patricia Aluko
BACKGROUND: Stress urinary incontinence constitutes a significant health and economic burden to society. Traditional suburethral slings are one of the surgical operations used to treat women with symptoms of stress urinary incontinence. OBJECTIVES: To determine the effects of traditional suburethral slings on stress or mixed incontinence in comparison with other management options. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Register (searched 3 June 2010) and the reference lists of relevant articles...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28743091/performance-comparison-of-two-herbal-and-industrial-medicines-using-nanoparticles-with-a-starch-cellulose-shell-and-alginate-core-for-drug-delivery-in-vitro-studies
#2
Akbar Esmaeili, Sahar Behzadi
In this study, the performance of two kinds of industrial and herbal drugs encapsulated in nanoparticles with a shell of starch and cellulose and an alginate core were examined as a new technique for nanoparticle drug delivery. The test method involved creating a suspension of starch and alginate, which was then dried, mixed with cellulose, and heated to form core-shell nanoparticles. The industrial drug calcitonin and an extract of the herb Amaranthus retroflexcus L. were added separately and in combination to the nanoparticles, and the performance of each configuration was evaluated...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28742771/perioperative-amino-acid-infusion-for-preventing-hypothermia-and-improving-clinical-outcomes-during-surgery-under-general-anesthesia-a-systematic-review-and-meta-analysis
#3
Yoshitaka Aoki, Yukie Aoshima, Kazuyuki Atsumi, Ryo Kaminaka, Rintaro Nakau, Kyoko Yanagita, Makiko Kora, Shunsuke Fujii, Junichiro Yokoyama
Amino acid (AA) infusion is sometimes selected to avoid hypothermia during general anesthesia. However, the widespread clinical use of AA infusion therapy has not been established. This study aimed to clarify the evidence that AA infusion can increase patient body temperature and improve clinical outcomes using the Grading of Recommendations Assessment, Development, and Evaluation system. We searched MEDLINE (PubMed), Cochrane Central Register of Controlled Trials, and Igaku Chuo Zasshi (Japana Centra Revuo Medicina) in November 2015...
July 24, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28742627/measurement-error-of-a-simplified-protocol-for-quantitative-sensory-tests-in-chronic-pain-patients
#4
Monika Müller, José Alberto Biurrun Manresa, Andreas Limacher, Konrad Streitberger, Peter Jüni, Ole Kæseler Andersen, Michele Curatolo
BACKGROUND AND OBJECTIVES: Large-scale application of Quantitative Sensory Tests (QST) is impaired by lacking standardized testing protocols. One unclear methodological aspect is the number of records needed to minimize measurement error. Traditionally, measurements are repeated 3 to 5 times, and their mean value is considered. When transferring QST to a clinical setting, reducing the number of records would be desirable to meet the time constraints encountered in a routine clinical environment and to reduce the testing burden to chronic pain patients...
July 24, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28742281/structured-identification-of-response-options-to-address-environmental-health-risks-at-the-agbogbloshie-electronic-waste-site
#5
Danielle Cazabon, Julius N Fobil, George Essegbey, Niladri Basu
Electronic waste (E-waste) is a growing problem across low- and middle-income countries. Agbogbloshie (Accra, Ghana) is among the world's largest and most notorious e-waste sites, with an increasing number of studies documenting a range of environmental health risks. This study aimed to provide national, regional, and international stakeholders with a summary of expert opinion on the most pressing problems arising from e-waste activities at Agbogbloshie, as well as suggested solutions to address these problems...
July 25, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28742267/profiling-the-effects-of-short-time-course-cold-ischemia-on-tumor-protein-phosphorylation-using-a-bayesian-approach
#6
You Wu, Jeremy Gaskins, Maiying Kong, Susmita Datta
Phosphorylated proteins provide insight into tumor etiology and are used as diagnostic, prognostic, and therapeutic markers of complex diseases. However, pre-analytic variations, such as freezing delay after biopsy acquisition, often occur in real hospital settings and potentially lead to inaccurate results. The objective of this work is to develop statistical methodology to assess the stability of phosphorylated proteins under short-time cold ischemia. We consider a hierarchical model to determine if phosphorylation abundance of a protein at a particular phosphorylation site remains constant or not during cold ischemia...
July 25, 2017: Biometrics
https://www.readbyqxmd.com/read/28742263/progesterone-receptor-modulators-for-endometriosis
#7
REVIEW
Jing Fu, Hao Song, Min Zhou, Huili Zhu, Yuhe Wang, Hengxi Chen, Wei Huang
BACKGROUND: Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. OBJECTIVES: To assess the effectiveness and safety of PRMs primarily in terms of pain relief as compared with other treatments or placebo or no treatment in women of reproductive age with endometriosis...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28742224/synthesis-of-unimolecular-micelles-with-incorporated-hyperbranched-boltorn-h30-polyester-modified-with-hyperbranched-helical-poly-phenyl-isocyanide-chains-and-their-enantioselective-crystallization-performance
#8
Zhi-Huang Zhang, Chen-Yang Qiao, Jian Zhang, Wen-Ming Zhang, Jun Yin, Zong-Quan Wu
Here, the fabrication of unimolecular micelles functionalized with helical polymeric chains as a chiral nucleating agent in enantioselective crystallization is reported. Starting from a fractionated hyperbranched polyester (Boltorn H30), the ring-opening polymerization of l-lactic acid (LLA) and subsequent terminal-group modification affords the alkyne-Pd(II)-anchored hyperbranched macroinitiator (H30-PLLA-Pd). By taking advantage of a Pd(II)-catalyzed living polymerization of chiral pendant modified l- or d-phenyl isocyanide (PI) monomers, well-defined chiral unimolecular micelles (H30-PLLA-PPI) grafted with radiating helical PPI coronas of one predominant screw sense are obtained...
July 25, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28742219/model-free-scoring-system-for-risk-prediction-with-application-to-hepatocellular-carcinoma-study
#9
Weining Shen, Jing Ning, Ying Yuan, Anna S Lok, Ziding Feng
There is an increasing need to construct a risk-prediction scoring system for survival data and identify important risk factors (e.g., biomarkers) for patient screening and treatment recommendation. However, most existing methodologies either rely on strong model assumptions (e.g., proportional hazards) or only handle binary outcomes. In this article, we propose a flexible method that simultaneously selects important risk factors and identifies the optimal linear combination of risk factors by maximizing a pseudo-likelihood function based on the time-dependent area under the receiver operating characteristic curve...
July 25, 2017: Biometrics
https://www.readbyqxmd.com/read/28741979/systematic-review-of-the-literature-on-triclosan-and-health-outcomes-in-humans
#10
Michael Goodman, Daniel Q Naiman, Judy S LaKind
The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain - overall design, exposure assessment, and data analysis - was categorized according to three tiers where Tier 1 indicated the highest quality...
July 25, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28741886/preparation-of-polyfunctional-diorgano-magnesium-and-zinc-reagents-using-in-situ-trapping-halogen-lithium-exchange-of-highly-functionalized-hetero-aryl-halides-in-continuous-flow
#11
Marthe Ketels, Maximilian Andreas Ganiek, Niels Weidmann, Paul Knochel
We report a halogen-lithium exchange performed in the presence of various metal salts (ZnCl2, MgCl2·LiCl) on a broad range of sensitive bromo- or iodo-(hetero)arenes using BuLi or PhLi as exchange reagent and a commercially available continuous flow setup. The resulting diarylmagnesium or diarylzinc species were trapped with various electrophiles resulting in the formation of polyfunctional (hetero)arenes in high yields. This methodology enabled the functionalization of (hetero)arenes containing highly sensitive groups such as an isothiocyanate, nitro, azide or ester...
July 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28741842/a-cu-pd-synergistic-dual-catalysis-for-enantioselective-allylic-alkylation-of-aldimine-esters-a-facile-access-to-alpha-alpha-disubstituted-alpha-amino-acids
#12
Chun-Jiang Wang, Liang Wei, Shi-Ming Xu, Qiao Zhu, Chao Che
An unprecedented enantioselective allylic alkylation of readily-available aldimine esters has been developed, which was efficiently catalyzed by a Cu/Pd synergistic dual catalyst. This strategy provides a facile access to nonproteinogenic alpha,alpha-disubstituted alpha-amino acids (alpha-AAs) in high yield with excellent enantioselectivity. The more challenging double allylic allylation of glycinate derived imine esters could also be realized. Furthermore, this methodology was applied for the construction of the key intermediate of PLG peptidomimetics...
July 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28741808/reconciling-disparate-data-to-determine-the-right-answer-a-grounded-theory-of-meta-analysts-reasoning-in-meta-analysis
#13
Lisa Chan, Mary Ellen Macdonald, Franco A Carnevale, Russ Steele, Ian Shrier
While the systematic review process is intended to maximize objectivity and limit researchers' biases, examples remain of discordant recommendations from meta-analyses. Current guidelines to explore discrepancies assume the variation is produced by methodological differences, and thus focus only on the study process. Since heterogeneity of interpretation also occurs when experts examine the same data, our purpose was to examine if there are 'reasoning' differences, i.e., in how information is processed and valued...
July 25, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28741787/advances-in-stereoselective-1-2-cis-glycosylation-using-c-2-auxiliaries
#14
Rens Mensink, Thomas Jan Boltje
The control of stereoselectivity in a glycosylation reaction remains one of the most challenging aspects of oligosaccharide synthesis. Especially the synthesis of 1,2-cis-glycosides is challenging and generally applicable methodology to prepare this linkage is needed to standardize oligosaccharide synthesis. This review highlights the recent development of an elegant strategy employing a C-2 auxiliary to control the anomeric stereoselectivity in glycosylations. The various auxiliaries developed to date, their compatibility with protecting groups and monosaccharide types as well as mechanistic aspects are summarized...
July 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28741672/finding-of-increased-caudate-nucleus-in-patients-with-alzheimer-s-disease
#15
K Persson, V D Bohbot, N Bogdanovic, G Selbaek, A Braekhus, K Engedal
OBJECTIVES: A recently published study using an automated MRI volumetry method (NeuroQuant®) unexpectedly demonstrated larger caudate nucleus volume in patients with Alzheimer's disease dementia (AD) compared to patients with subjective and mild cognitive impairment (SCI and MCI). The aim of this study was to explore this finding. MATERIALS & METHODS: The caudate nucleus and the hippocampus volumes were measured (both expressed as ratios of intracranial volume) in a total of 257 patients with SCI and MCI according to the Winblad criteria and AD according to ICD-10 criteria...
July 25, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28741465/engineering-of-chimeric-protein-based-on-e-protein-domain-iii-of-tick-borne-encephalitis-virus-and-ompf-porin-of-yersinia-pseudotuberculosis
#16
Anna M Stenkova, Natalia S Chopenko, Ludmila A Davydova, Andrey N Mazeika, Evgeniya P Bystritskaya, Olga Y Portnyagina, Stanislav D Anastyuk, Dmitrii S Kulbatskii, Ekaterina N Lyukmanova, Dmitriy A Dolgikh, Eduard Y Kostetsky, Nina M Sanina
Tick-borne encephalitis poses a serious public health threat in the endemic regions. The disease treatment is restricted to symptomatic therapy, so great expectations are in the development of the prophylactic and therapeutic vaccines. The domain III of E protein of the tick-borne encephalitis virus is the main antigenic domain which includes virus-specific epitopes recognized by neutralizing antibodies. We have expressed, isolated and characterized the chimeric protein based on the fusion of domain III of E protein of the tick-borne encephalitis virus and bacterial porin OmpF from Yersinia pseudotuberculosis...
July 24, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28741442/a-systematic-review-of-the-methods-of-diagnostic-accuracy-studies-of-the-afirma%C3%A2-gene-expression-classifier
#17
Quan-Yang Duh, Naifa Busaidy, Catherine Rahilly-Tierney, Hossein Gharib, Gregory W Randolph
BACKGROUND: The Afirma® Gene Expression Classifier (GEC) risk-stratifies Bethesda System for the Reporting of Thyroid Cytopathology class III/IV (indeterminate) thyroid nodules (ITNs) as Suspicious for malignancy or Benign. Several authors have published studies describing the diagnostic accuracy of the GEC. However, the quality of these methods has not been rigorously examined. SUMMARY: We searched Medline and EMBASE for studies published between January 1, 2010 and June 30, 2016 examining the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the GEC...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28741392/recent-advances-in-the-development-and-use-of-molecular-tests-to-predict-antimicrobial-resistance-in-neisseria-gonorrhoeae
#18
Valentina Donà, Nicola Low, Daniel Golparian, Magnus Unemo
The number of genetic tests, mostly real-time PCRs, to detect antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae is increasing. Several of these assays are promising, but there are important shortcomings and few assays have been adequately validated and quality assured. Areas covered: Recent advances, focusing on publications since 2012, in the development and use of molecular tests to predict gonococcal AMR for surveillance and for clinical use, advantages and disadvantages of these tests and of molecular AMR prediction compared with phenotypic AMR testing, and future perspectives for effective use of molecular AMR tests for different purposes...
July 25, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28741377/renal-cell-carcinoma-alternative-nephron-sparing-treatment-options-for-small-renal-masses-a-systematic-review
#19
Fieke M Prins, Linda G W Kerkmeijer, Anne A Pronk, Evert-Jan P A Vonken, Richard P Meijer, Axel Bex, Maurits M Barendrecht
<i>Background</i> The standard treatment of T1 renal cell carcinoma is (partial-) nephrectomy. For patients where surgery is not the treatment of choice, for example in the elderly, in case of severe comorbidity, inoperability or refusal of surgery, alternative treatment options are available. These treatment options include active surveillance, radiofrequency ablation, cryoablation, microwave ablation or stereotactic body radiotherapy. In the present overview, the efficacy, safety and outcome of these different options are summarized, particularly focusing on recent developments...
July 25, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28741344/anidulafungin-in-children-experience-in-a-tertiary-care-children-s-hospital-in-argentina
#20
María T Rosanova, Claudia Sarkis, Florencia Escarra, Carolina Epelbaum, Norma Sberna, Susana Carnovale, Carlos Figueroa, Rosa Bologna, Roberto Lede
The experience using anidulafungin for the treatment of invasive fungal infections in pediatrics is limited. In this article, we describe our experience in 55 children. Anidulafungin was administered intravenously at a loading dose of 3 mg/kg once daily, followed by 1.5 mg/kg every 24 hours over a mean period of 14 days (range: 7-22 days). Patients' median age was 114 months old (interquartile range: 32-168 months old). All patients had underlying diseases. Among patients with bone marrow transplant, the difference in white blood cell count, transaminase levels, and renal function at baseline and at the end of anidulafungin administration was not significant...
August 1, 2017: Archivos Argentinos de Pediatría
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