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pediatric bacterial meningitis

Ali Bilal, Muhamed-Kheir Taha, Laurence Caeymaex, Robert Cohen, Corinne Levy, Xavier Durrmeyer
Among 831 cases of neonatal bacterial meningitis occurring from 2001 to 2013, Neisseria meningitidis was the third most frequent bacterial species found. All cases occurred only in term neonates and were mainly late onset. Serogroup B accounted for 78% of cases. At diagnosis, 27% of cases had at least one sign of disease severity. All strains were susceptible to cefotaxime, but 12% showed intermediate susceptibility to penicillin G and to aminopenicillin.
November 2016: Pediatric Infectious Disease Journal
Laurence Ducharme-Crevier, Michele G Mills, Priya M Mehta, Craig M Smith, Mark S Wainwright
BACKGROUND: The primary objective of this study was to characterize changes in cerebral blood flow measured using transcranial Doppler in children with central nervous system infections. We hypothesized that children with central nervous system infections have abnormal cerebral blood flow, associated with a greater frequency of complications and poor neurological outcome. METHODS: We conducted a single-center, retrospective study of children admitted to the neonatal or pediatric intensive care unit with central nervous system infection and undergoing transcranial Doppler as part of routine care between March 2011 and July 2015...
September 4, 2016: Pediatric Neurology
Mansour Amin, Mozhgan Ghaderpanah, Tahereh Navidifar
Meningitis is a life-threatening infection associated with a high mortality and morbidity worldwide. Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae are the most prevalent infectious agents that cause bacterial meningitis (BM). The objective of this study was to determine the frequencies of these three bacteria using bacterial cultures and polymerase chain reaction (PCR). In our cross-sectional study, cerebrospinal fluid (CSF) specimens were obtained from 196 patients who were suspected of having BM and referred to the pediatric ward of Abuzar Hospital (Ahvaz, Iran)...
October 2016: Kaohsiung Journal of Medical Sciences
Gamze Ozgurhan, Oznur Vermezoglu, Didem Ocal Topcu, Adem Karbuz, Aysel Vehapoglu, Bulent Hacihamdioglu
Although rotavirus gastroenteritis is quite common in the pediatric population, secondary bacterial sepsis following rotavirus infection is a rare clinical entity. Gram-negative bacilli are the fifth most common cause of meningitis in infants but this infection rarely occurs after gastroenteritis. Here, we report a 2.5-month-old infant who developed Escherichia coli (E. coli) meningitis after acute rotavirus gastroenteritis. The 2.5-month-old male infant with fever, vomiting, and watery diarrhea that started 1 day earlier was admitted to the hospital...
2016: Case Reports in Infectious Diseases
Maurice Gatera, Jeannine Uwimana, Emmanuel Manzi, Fidele Ngabo, Friday Nwaigwe, Bradford D Gessner, Jennifer C Moïsi
BACKGROUND: Ongoing surveillance is critical to assessing pneumococcal conjugate vaccine (PCV) impact over time. However, robust prospective studies are difficult to implement in resource-poor settings. We evaluated retrospective use of routinely collected data to estimate PCV impact in Rwanda. METHODS: We collected data from admission registers at five district hospitals on children age <5yearsadmitted for suspected meningitis and pneumonia during 2002-2012...
October 17, 2016: Vaccine
Enrique Chacon-Cruz, Cesar Adrian Martinez-Longoria, Eduardo Llausas-Magana, Antonio Luevanos-Velazquez, Jorge Alejandro Vazquez-Narvaez, Sandra Beltran, Ana Elena Limon-Rojas, Fernando Urtiz-Jeronimo, Jose Luis Castaneda-Narvaez, Francisco Otero-Mendoza, Fernando Aguilar-Del Real, Jesus Rodriguez-Chagoyan, Rosa Maria Rivas-Landeros, Maria Luisa Volker-Soberanes, Rosa Maria Hinojosa-Robles, Patricia Arzate-Barbosa, Laura Karina Aviles-Benitez, Fernando Ivan Elenes-Zamora, Chandra M Becka, Ricardo Ruttimann
OBJECTIVES: Meningococcal meningitis is reported as a rare condition in Mexico. There are no internationally published studies on bacterial causes of meningitis in the country based on active surveillance. This study focuses on finding the etiology of bacterial meningitis in children from nine Mexican Hospitals. METHODS: From January 2010 to February 2013, we conducted a three years of active surveillance for meningitis in nine hospitals throughout Mexico. Active surveillance started at the emergency department for every suspected case, and microbiological studies confirmed/ruled out all potentially bacterial pathogens...
January 2016: Therapeutic Advances in Vaccines
Hideyuki Okui, Chie Fukasawa, Shoko Tokutake, Haruka Takei, Junichi Sato, Tadashi Hoshino
We report the case of a pediatric patient in whom a spinal congenital dermal sinus was detected after the onset of anaerobic bacterial meningitis. The patient was a 4-month-old boy. He had a recurrent fever for 2 weeks before admission. On admission, he presented with a convulsive status and a bulging anterior fontanel. The previously consulted physician had made a diagnosis of bacterial meningitis. Spinal fluid cultures tested positive for Peptoniphilus asaccharolyticus. Magnetic resonance imaging (MRI) showed a spinal subdural abscess and cranial subdural hydrops; therefore, the patient was transported to our hospital for surgical treatment...
May 2016: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
Lakshmi Srinivasan, Laurie Kilpatrick, Samir S Shah, Soraya Abbasi, Mary C Harris
BACKGROUND: Bacterial meningitis poses diagnostic challenges in infants. Antibiotic pretreatment and low bacterial density diminish cerebrospinal fluid (CSF) culture yield, while laboratory parameters do not reliably identify bacterial meningitis. Pro and anti-inflammatory cytokines are elevated in bacterial meningitis and may be useful diagnostic adjuncts when CSF cultures are negative. METHODS: In a prospective cohort study of infants, we used cytometric bead arrays to measure tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), IL-6, IL-8, IL-10, and IL-12 in CSF...
October 2016: Pediatric Research
Mohammad Javad Ghabouli Shahroodi, Kiarash Ghazvini, Reza Sadeghi, Mohammad Saeed Sasan
BACKGROUND: The highest incidence of meningitis occurs during the neonatal period and (then) infancy. Although Bacterial agents are the most dangerous cause of neonatal and childhood meningitis yet viruses especially, enteroviruses (EV), are by far the most common cause of meningitis in this age group. OBJECTIVES: The aim of the current study was to evaluate the role of EVs in neonatal and childhood meningitis in the Mashhad city of Iran. MATERIALS AND METHODS: This was a descriptive study that was performed at Imam Reza hospital in a period of six months (March to September 2007), during which all of the cerebral spinal fluid (CSF) samples from the neonatal intensive care unit (NICU) and pediatrics ward were collected and real time-polymerase chain reaction (RT-PCR) for EVs was done on these samples...
May 2016: Jundishapur Journal of Microbiology
Ling-Yun Guo, Zhi-Xiao Zhang, Xi Wang, Ping-Ping Zhang, Wei Shi, Kai-Hu Yao, Lin-Lin Liu, Gang Liu, Yong-Hong Yang
OBJECTIVES: To explore the clinical characteristics and analyze the pathogens of bacterial meningitis in children. METHODS: Bacterial meningitis cases occurring from January 2010 through December 2014 at Beijing Children's Hospital were reviewed retrospectively. The records of all patients, including data on clinical features and laboratory information, were obtained and analyzed. RESULTS: In total, the cases of 507 pediatric patients seen over a 5-year period were analyzed; 220 of these cases were etiologically confirmed...
September 2016: International Journal of Infectious Diseases: IJID
Ali Bilal, Muhamed-Kheir Taha, Laurence Caeymaex, Robert Cohen, Corinne Levy, Xavier Durrmeyer
Among 831 cases of neonatal bacterial meningitis occuring from 2001 to 2013, Neisseria meningitidis was the third most frequent bacterial species found. All cases occurred only in term neonates and were mainly late-onset. Serogroup B accounted for 78% of cases. At diagnosis, 27% of cases had at least 1 sign of disease severity. All strains were susceptible to cefotaxime, but 12% showed intermediate susceptibility to penicillin G and to aminopenicillin.
July 11, 2016: Pediatric Infectious Disease Journal
A Audemard-Verger, E Descloux, D Ponard, A Deroux, B Fantin, C Fieschi, M John, A Bouldouyre, L Karkowsi, G Moulis, H Auvinet, F Valla, C Lechiche, B Davido, M Martinot, C Biron, F Lucht, N Asseray, A Froissart, R Buzelé, A Perlat, D Boutboul, V Fremeaux-Bacchi, S Isnard, B Bienvenu
Complement system is a part of innate immunity, its main function is to protect human from bacterial infection. As genetic disorders, complement deficiencies are often diagnosed in pediatric population. However, complement deficiencies can also be revealed in adults but have been poorly investigated. Herein, we describe a case series of infections revealing complement deficiency in adults to study clinical spectrum and management of complement deficiencies.A nationwide retrospective study was conducted in French university and general hospitals in departments of internal medicine, infectious diseases enrolling patients older than 15 years old who had presented at least one infection leading to a complement deficiency diagnosis...
May 2016: Medicine (Baltimore)
William Bonadio, Felix Huang, Sinthumathi Nateson, Chukwujekwu Okpalaji, Alicia Kodsi, Sabrina Sokolovsky, Peter Homel
OBJECTIVES: This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis). METHODS: We evaluated consecutive febrile neonates 28 days or younger presenting to our urban pediatric emergency department [Maimonides Medical Center (MMC)] during a 6-year period, all of whom received a sepsis evaluation (cerebrospinal fluid, blood, urine cultures) and RSV NPAT...
May 2016: Pediatric Emergency Care
Qing Ye, Wen-Xia Shao, Shi-Qiang Shang, Hong-Qiang Shen, Xue-Jun Chen, Yong-Min Tang, Yong-Lin Yu, Jian-Hua Mao
We performed a prospective observational study to evaluate the utility of measuring inflammatory cytokine levels to discriminate bacterial meningitis from similar common pediatric diseases. Inflammatory cytokine levels and other cerebrospinal fluid (CSF) physicochemical indicators were evaluated in 140 patients who were diagnosed with bacterial meningitis via microbiological culture or PCR assay. The CSF concentrations of interleukin (IL)-6 and IL-10, CSF/blood IL-6 and IL-10 ratios, CSF white blood cell count, and CSF micro total protein were significantly elevated in bacterial meningitis patients compared with healthy children or patients with viral encephalitis, epilepsy, or febrile convulsions (P < 0...
March 2016: Medicine (Baltimore)
C Briand, C Levy, F Baumie, L Joao, S Béchet, E Carbonnelle, E Grimprel, R Cohen, J Gaudelus, L de Pontual
OBJECTIVE: Pediatricians are well aware of the immediate risks of bacterial meningitis in children. However, the long-term outcome of the disease has not been extensively studied. We aimed: (i) to evaluate the duration and quality of the long-term follow-up of children diagnosed with bacterial meningitis in a general pediatric department, (ii) to estimate the incidence of sequelae at the various stages of follow-up, and (iii) to compare our data with that of other studies. METHODS: We conducted a retrospective study and included 34 children (3 months-15 years) who had been hospitalized for bacterial meningitis in the pediatric department of a University Hospital between January 1st, 2001 and December 31st, 2013...
June 2016: Médecine et Maladies Infectieuses
Kayo Morita, Yu-ichi Abe, Atsushi Itano, Ikuma Musha, Takeshi Koga, Taro Yamazaki, Hideo Yamanouchi
Chloramphenicol (CP) is recently one of the rarely-used antibiotics. In this study, we present four patients with intractable bacterial meningitis, who were successfully treated with CP and discuss the therapeutic indications of CP in these pediatric cases. The patients were diagnosed as bacterial meningitis at the ages ranging from 2 months to 1 year and 4 months. The causative organisms found in three of the patients were H. influenzae and in the fourth patient, S. pneumoniae. According to the microbial sensitivity tests, these organisms were highly sensitive to antibiotics including ceftriaxone, meropenem and/or panipenem/betamipron...
January 2016: No to Hattatsu. Brain and Development
Angelin A Jebamalar, Agiesh K Balakrishnapillai, Narayanan Parmeswaran, Pooja Dhiman, Soundravally Rajendiran
OBJECTIVES: To evaluate the diagnostic role of cerebrospinal fluid (CSF) ferritin and albumin index (AI = CSF albumin/serum albumin × 1000) in differentiating acute bacterial meningitis (ABM) from acute viral meningitis (AVM) in children. METHODS: The study included 42 cases each of ABM and AVM in pediatric age group. Receiver operating characteristic (ROC) analysis was carried out for CSF ferritin and AI. Binary logistic regression was also done. RESULTS: CSF ferritin and AI were found significantly higher in ABM compared to AVM...
July 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Ayşe Kaman, Türkan Aydın-Teke, Fatma Nur Öz, Gülsüm İclal Bayhan, Özge Metin, Zeynep Gökçe Gayretli-Aydın, Gönül Tanır
Streptococcus pneumoniae is a leading cause of bacterial meningitis in children. It is also responsible for bacteremia, sepsis, pneumonia, sinusitis and acute otitis media in young children worldwide. The serotypes included in the 7-valent conjugated pneumococcal vaccine (PCV7)-1, 5, 6A, 6B, 14, 19F, 23F-are those most commonly responsible for invasive pneumococcal disease (IPD) globally. Unvaccinated children are at greater risk for meningitis. The rate of non-vaccine serotypes as causes of invasive disease has increased...
May 2015: Turkish Journal of Pediatrics
N Elenga, S Sicard, E Cuadro-Alvarez, L Long, F Njuieyon, E Martin, R Kom-Tchameni, J Balcaen, B Moreau, R Boukhari
OBJECTIVE: Controlling vaccine-preventable infectious diseases is a public health priority in French Guiana but there is currently no epidemiological data on pediatric bacterial meningitis in this overseas department. Our aim was to describe data related to pediatric bacterial meningitis in French Guiana and compare it with that of metropolitan France. METHODS: We conducted a multicenter retrospective study from 2000 to 2010 to describe the clinical picture, biological data, epidemiology, and outcome of pediatric bacterial meningitis case patients in French Guiana...
November 2015: Médecine et Maladies Infectieuses
Karen Milcent, Sabine Faesch, Christèle Gras-Le Guen, François Dubos, Claire Poulalhon, Isabelle Badier, Elisabeth Marc, Christine Laguille, Loïc de Pontual, Alexis Mosca, Gisèle Nissack, Sandra Biscardi, Hélène Le Hors, Ferielle Louillet, Andreea Madalina Dumitrescu, Philippe Babe, Christelle Vauloup-Fellous, Jean Bouyer, Vincent Gajdos
IMPORTANCE: The procalcitonin (PCT) assay is an accurate screening test for identifying invasive bacterial infection (IBI); however, data on the PCT assay in very young infants are insufficient. OBJECTIVE: To assess the diagnostic characteristics of the PCT assay for detecting serious bacterial infection (SBI) and IBI in febrile infants aged 7 to 91 days. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study that included infants aged 7 to 91 days admitted for fever to 15 French pediatric emergency departments was conducted for a period of 30 months (October 1, 2008, through March 31, 2011)...
January 2016: JAMA Pediatrics
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