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https://www.readbyqxmd.com/read/27902653/meningococcal-disease-in-children-in-argentina-a-three-year-active-sentinel-hospital-surveillance-study
#1
Ángela Gentile, Julia Bakir, María Rosa Agosti, Gabriela Ensinck, Hector Abate, Andrea Gajo Gane, Alejandro Santillán Iturres, Adriana Efron, Mabel Regueira, Ricardo Rüttimann
BACKGROUND: Meningococcal disease (MD) is a medical emergency and a serious public health problem. As new meningococcal vaccines become available, MD surveillance is crucial to provide baseline epidemiologic data before implementing preventive measures. We estimated MD incidence and epidemiology in Argentina using hospital-based surveillance. METHODS: 3-year prospective active surveillance in patients ≤15 years of age conducted at 6 pediatric hospital sentinel units (March 2012-February 2015)...
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27887787/vascular-endothelial-growth-factor-vegf-and-platelet-derived-growth-factor-pdgf-levels-in-the-cerebrospinal-fluid-of-children-with-influenza-associated-encephalopathy
#2
Shinichiro Morichi, Natsumi Morishita, Mika Takeshita, Yu Ishida, Shingo Oana, Gaku Yamanaka, Yasuyo Kashiwagi, Hisashi Kawashima
INTRODUCTION: To search for an index of neurologic prognosis of children with influenza-associated encephalopathy (IAE), involvement of angiogenesis-related growth factors in the pathology was investigated. PATIENTS AND METHODS: The subjects were 11 IAE patients, 6 patients with bacterial meningitis (BM), and 24 patients with non-central nervous system infection as a control group admitted to our hospital. The correlation between the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) levels in cerebrospinal fluid and the relationship with an index of inflammatory marker, interleukin (IL)-6, were investigated...
November 23, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27879558/impact-of-pneumococcal-conjugate-vaccines-on-selected-head-and-neck-infections-in-hospitalized-israeli-children
#3
Tal Marom, Shiran Bookstein Peretz, Orna Schwartz, Abraham Goldfarb, Yahav Oron, Sharon Ovnat Tamir
INTRODUCTION: Streptococcus pneumoniae is a major pathogen of pediatric head and neck infections (HNIs), e.g. acute otitis media (AOM), acute mastoiditis (AM), acute bacterial sinusitis (ABS) and meningitis. The aim of the study was to characterize the epidemiology of pneumococcal HNIs (pHNIs) before, during, and after the introduction of pneumococcal conjugate vaccines (PCVs). METHODS: Children 0-16 years who were hospitalized with HNIs in the Pediatrics Department in a general hospital between 1/1/2007-12/31/2014 were retrospectively identified...
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27832151/nationwide-trends-in-bacterial-meningitis-before-the-introduction-of-13-valent-pneumococcal-conjugate-vaccine-burkina-faso-2011-2013
#4
Dinanibè Kambiré, Heidi M Soeters, Rasmata Ouédraogo-Traoré, Isaïe Medah, Lassana Sangare, Issaka Yaméogo, Guetawendé Sawadogo, Abdoul-Salam Ouédraogo, Soumeya Hema-Ouangraoua, Lesley McGee, Velusamy Srinivasan, Flavien Aké, Malika Congo-Ouédraogo, Soufian Sanou, Absatou Ky Ba, Ryan T Novak, Chris Van Beneden
BACKGROUND: Following introduction of Haemophilus influenzae type b vaccine in 2006 and serogroup A meningococcal conjugate vaccine in 2010, Streptococcus pneumoniae (Sp) became the leading cause of bacterial meningitis in Burkina Faso. We describe bacterial meningitis epidemiology, focusing on pneumococcal meningitis, before 13-valent pneumococcal conjugate vaccine (PCV13) introduction in the pediatric routine immunization program in October 2013. METHODS: Nationwide population-based meningitis surveillance collects case-level demographic and clinical information and cerebrospinal fluid (CSF) laboratory results...
2016: PloS One
https://www.readbyqxmd.com/read/27811110/whole-genome-shotgun-sequencing-of-the-first-observation-of-neisseria-meningitidis-sequence-type-6928-in-india
#5
Balaji Veeraraghavan, Ayyan Raj Neeravi, Naveen Kumar Devanga Ragupathi, Francis Yesurajan Inbanathan, Agila Kumari Pragasam, Valsan Philip Verghese
Neisseria meningitidis is one of the leading global causes of bacterial meningitis. Here, we discuss the draft genome sequences of two N. meningitidis strains, isolated from bloodstream infections in two pediatric patients at a tertiary care hospital in South India. The sequence data indicate that strains VB13856 and VB15548 encode genomes of ~2.09 Mb in size with no plasmids.
November 3, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27771208/comparative-evaluation-of-the-filmarray-meningitis-encephalitis-molecular-panel-in-a-pediatric-population
#6
Erin H Graf, Maria Victoria Farquharson, Ana María Cárdenas
We compared an FDA cleared molecular meningitis/encephalitis panel to lab developed viral PCRs and bacterial culture. Of the 67 viral PCR or bacterial culture-positive samples, 92.5% were positive for the same target by the panel. Of the 66 negative samples tested, no targets were detected by the panel, for an agreement of 96.2%.
October 1, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27753774/neonatal-meningococcal-meningitis-in-france-from-2001-to-2013
#7
Ali Bilal, Muhamed-Kheir Taha, Laurence Caeymaex, Robert Cohen, Corinne Levy, Xavier Durrmeyer
Among 831 cases of neonatal bacterial meningitis occurring from 2001 to 2013, Neisseria meningitidis was the third most frequent bacterial species found. All cases occurred only in term neonates and were mainly late onset. Serogroup B accounted for 78% of cases. At diagnosis, 27% of cases had at least one sign of disease severity. All strains were susceptible to cefotaxime, but 12% showed intermediate susceptibility to penicillin G and to aminopenicillin.
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27743745/use-of-transcranial-doppler-for-management-of-central-nervous-system-infections-in-critically-ill-children
#8
Laurence Ducharme-Crevier, Michele G Mills, Priya M Mehta, Craig M Smith, Mark S Wainwright
BACKGROUND: The primary objective of this study was to characterize changes in cerebral blood flow measured using transcranial Doppler in children with central nervous system infections. We hypothesized that children with central nervous system infections have abnormal cerebral blood flow, associated with a greater frequency of complications and poor neurological outcome. METHODS: We conducted a single-center, retrospective study of children admitted to the neonatal or pediatric intensive care unit with central nervous system infection and undergoing transcranial Doppler as part of routine care between March 2011 and July 2015...
December 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27742033/detection-of-haemophilus-influenzae-type-b-streptococcus-agalactiae-streptococcus-pneumoniae-and-neisseria-meningitidis-in%C3%A2-csf%C3%A2-specimens-of-children-suspicious-of%C3%A2-meningitis-in-ahvaz-iran
#9
Mansour Amin, Mozhgan Ghaderpanah, Tahereh Navidifar
Meningitis is a life-threatening infection associated with a high mortality and morbidity worldwide. Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae are the most prevalent infectious agents that cause bacterial meningitis (BM). The objective of this study was to determine the frequencies of these three bacteria using bacterial cultures and polymerase chain reaction (PCR). In our cross-sectional study, cerebrospinal fluid (CSF) specimens were obtained from 196 patients who were suspected of having BM and referred to the pediatric ward of Abuzar Hospital (Ahvaz, Iran)...
October 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27738536/escherichia-coli-meningitis-after-rotavirus-gastroenteritis-in-an-infant
#10
Gamze Ozgurhan, Oznur Vermezoglu, Didem Ocal Topcu, Adem Karbuz, Aysel Vehapoglu, Bulent Hacihamdioglu
Although rotavirus gastroenteritis is quite common in the pediatric population, secondary bacterial sepsis following rotavirus infection is a rare clinical entity. Gram-negative bacilli are the fifth most common cause of meningitis in infants but this infection rarely occurs after gastroenteritis. Here, we report a 2.5-month-old infant who developed Escherichia coli (E. coli) meningitis after acute rotavirus gastroenteritis. The 2.5-month-old male infant with fever, vomiting, and watery diarrhea that started 1 day earlier was admitted to the hospital...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27639280/use-of-administrative-records-to-assess-pneumococcal-conjugate-vaccine-impact-on-pediatric-meningitis-and-pneumonia-hospitalizations-in-rwanda
#11
Maurice Gatera, Jeannine Uwimana, Emmanuel Manzi, Fidele Ngabo, Friday Nwaigwe, Bradford D Gessner, Jennifer C Moïsi
BACKGROUND: Ongoing surveillance is critical to assessing pneumococcal conjugate vaccine (PCV) impact over time. However, robust prospective studies are difficult to implement in resource-poor settings. We evaluated retrospective use of routinely collected data to estimate PCV impact in Rwanda. METHODS: We collected data from admission registers at five district hospitals on children age <5yearsadmitted for suspected meningitis and pneumonia during 2002-2012...
October 17, 2016: Vaccine
https://www.readbyqxmd.com/read/27551428/neisseria-meningitidis-and-streptococcus-pneumoniae-as-leading-causes-of-pediatric-bacterial-meningitis-in-nine-mexican-hospitals-following-3-years-of-active-surveillance
#12
Enrique Chacon-Cruz, Cesar Adrian Martinez-Longoria, Eduardo Llausas-Magana, Antonio Luevanos-Velazquez, Jorge Alejandro Vazquez-Narvaez, Sandra Beltran, Ana Elena Limon-Rojas, Fernando Urtiz-Jeronimo, Jose Luis Castaneda-Narvaez, Francisco Otero-Mendoza, Fernando Aguilar-Del Real, Jesus Rodriguez-Chagoyan, Rosa Maria Rivas-Landeros, Maria Luisa Volker-Soberanes, Rosa Maria Hinojosa-Robles, Patricia Arzate-Barbosa, Laura Karina Aviles-Benitez, Fernando Ivan Elenes-Zamora, Chandra M Becka, Ricardo Ruttimann
OBJECTIVES: Meningococcal meningitis is reported as a rare condition in Mexico. There are no internationally published studies on bacterial causes of meningitis in the country based on active surveillance. This study focuses on finding the etiology of bacterial meningitis in children from nine Mexican Hospitals. METHODS: From January 2010 to February 2013, we conducted a three years of active surveillance for meningitis in nine hospitals throughout Mexico. Active surveillance started at the emergency department for every suspected case, and microbiological studies confirmed/ruled out all potentially bacterial pathogens...
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27529968/-pediatric-patient-with-anaerobic-bacterial-meningitis-who-was-infected-through-a-spinal-congenital-dermal-sinus-route
#13
Hideyuki Okui, Chie Fukasawa, Shoko Tokutake, Haruka Takei, Junichi Sato, Tadashi Hoshino
We report the case of a pediatric patient in whom a spinal congenital dermal sinus was detected after the onset of anaerobic bacterial meningitis. The patient was a 4-month-old boy. He had a recurrent fever for 2 weeks before admission. On admission, he presented with a convulsive status and a bulging anterior fontanel. The previously consulted physician had made a diagnosis of bacterial meningitis. Spinal fluid cultures tested positive for Peptoniphilus asaccharolyticus. Magnetic resonance imaging (MRI) showed a spinal subdural abscess and cranial subdural hydrops; therefore, the patient was transported to our hospital for surgical treatment...
May 2016: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
https://www.readbyqxmd.com/read/27486702/cerebrospinal-fluid-cytokines-in-the-diagnosis-of-bacterial-meningitis-in-infants
#14
Lakshmi Srinivasan, Laurie Kilpatrick, Samir S Shah, Soraya Abbasi, Mary C Harris
BACKGROUND: Bacterial meningitis poses diagnostic challenges in infants. Antibiotic pretreatment and low bacterial density diminish cerebrospinal fluid (CSF) culture yield, while laboratory parameters do not reliably identify bacterial meningitis. Pro and anti-inflammatory cytokines are elevated in bacterial meningitis and may be useful diagnostic adjuncts when CSF cultures are negative. METHODS: In a prospective cohort study of infants, we used cytometric bead arrays to measure tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), IL-6, IL-8, IL-10, and IL-12 in CSF...
October 2016: Pediatric Research
https://www.readbyqxmd.com/read/27478556/enteroviral-meningitis-in-neonates-and-children-of-mashhad-iran
#15
Mohammad Javad Ghabouli Shahroodi, Kiarash Ghazvini, Reza Sadeghi, Mohammad Saeed Sasan
BACKGROUND: The highest incidence of meningitis occurs during the neonatal period and (then) infancy. Although Bacterial agents are the most dangerous cause of neonatal and childhood meningitis yet viruses especially, enteroviruses (EV), are by far the most common cause of meningitis in this age group. OBJECTIVES: The aim of the current study was to evaluate the role of EVs in neonatal and childhood meningitis in the Mashhad city of Iran. MATERIALS AND METHODS: This was a descriptive study that was performed at Imam Reza hospital in a period of six months (March to September 2007), during which all of the cerebral spinal fluid (CSF) samples from the neonatal intensive care unit (NICU) and pediatrics ward were collected and real time-polymerase chain reaction (RT-PCR) for EVs was done on these samples...
May 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27452172/clinical-and-pathogenic-analysis-of-507-children-with-bacterial-meningitis-in-beijing-2010-2014
#16
Ling-Yun Guo, Zhi-Xiao Zhang, Xi Wang, Ping-Ping Zhang, Wei Shi, Kai-Hu Yao, Lin-Lin Liu, Gang Liu, Yong-Hong Yang
OBJECTIVES: To explore the clinical characteristics and analyze the pathogens of bacterial meningitis in children. METHODS: Bacterial meningitis cases occurring from January 2010 through December 2014 at Beijing Children's Hospital were reviewed retrospectively. The records of all patients, including data on clinical features and laboratory information, were obtained and analyzed. RESULTS: In total, the cases of 507 pediatric patients seen over a 5-year period were analyzed; 220 of these cases were etiologically confirmed...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27404598/neonatal-meningococcal-meningitis-in-france-from-2001-to-2013
#17
Ali Bilal, Muhamed-Kheir Taha, Laurence Caeymaex, Robert Cohen, Corinne Levy, Xavier Durrmeyer
Among 831 cases of neonatal bacterial meningitis occuring from 2001 to 2013, Neisseria meningitidis was the third most frequent bacterial species found. All cases occurred only in term neonates and were mainly late-onset. Serogroup B accounted for 78% of cases. At diagnosis, 27% of cases had at least 1 sign of disease severity. All strains were susceptible to cefotaxime, but 12% showed intermediate susceptibility to penicillin G and to aminopenicillin.
July 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27175654/infections-revealing-complement-deficiency-in-adults-a-french-nationwide-study-enrolling-41-patients
#18
A Audemard-Verger, E Descloux, D Ponard, A Deroux, B Fantin, C Fieschi, M John, A Bouldouyre, L Karkowsi, G Moulis, H Auvinet, F Valla, C Lechiche, B Davido, M Martinot, C Biron, F Lucht, N Asseray, A Froissart, R Buzelé, A Perlat, D Boutboul, V Fremeaux-Bacchi, S Isnard, B Bienvenu
Complement system is a part of innate immunity, its main function is to protect human from bacterial infection. As genetic disorders, complement deficiencies are often diagnosed in pediatric population. However, complement deficiencies can also be revealed in adults but have been poorly investigated. Herein, we describe a case series of infections revealing complement deficiency in adults to study clinical spectrum and management of complement deficiencies.A nationwide retrospective study was conducted in French university and general hospitals in departments of internal medicine, infectious diseases enrolling patients older than 15 years old who had presented at least one infection leading to a complement deficiency diagnosis...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27139289/meta-analysis-to-determine-risk-for-serious-bacterial-infection-in-febrile-outpatient-neonates-with-rsv-infection
#19
William Bonadio, Felix Huang, Sinthumathi Nateson, Chukwujekwu Okpalaji, Alicia Kodsi, Sabrina Sokolovsky, Peter Homel
OBJECTIVES: This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis). METHODS: We evaluated consecutive febrile neonates 28 days or younger presenting to our urban pediatric emergency department [Maimonides Medical Center (MMC)] during a 6-year period, all of whom received a sepsis evaluation (cerebrospinal fluid, blood, urine cultures) and RSV NPAT...
May 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27043692/clinical-value-of-assessing-cytokine-levels-for-the-differential-diagnosis-of-bacterial-meningitis-in-a-pediatric-population
#20
Qing Ye, Wen-Xia Shao, Shi-Qiang Shang, Hong-Qiang Shen, Xue-Jun Chen, Yong-Min Tang, Yong-Lin Yu, Jian-Hua Mao
We performed a prospective observational study to evaluate the utility of measuring inflammatory cytokine levels to discriminate bacterial meningitis from similar common pediatric diseases. Inflammatory cytokine levels and other cerebrospinal fluid (CSF) physicochemical indicators were evaluated in 140 patients who were diagnosed with bacterial meningitis via microbiological culture or PCR assay. The CSF concentrations of interleukin (IL)-6 and IL-10, CSF/blood IL-6 and IL-10 ratios, CSF white blood cell count, and CSF micro total protein were significantly elevated in bacterial meningitis patients compared with healthy children or patients with viral encephalitis, epilepsy, or febrile convulsions (P < 0...
March 2016: Medicine (Baltimore)
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