keyword
https://read.qxmd.com/read/38511552/seizures-focal-neurological-signs-and-pneumococcal-aetiology-associate-with-impaired-consciousness-in-childhood-bacterial-meningitis
#1
JOURNAL ARTICLE
Ester Valtiala, Irmeli Roine, Manuel Leite Cruzeiro, Heikki Peltola, Tuula Pelkonen
AIM: A low Glasgow Coma Scale Score (GCS) on admission is a known predictor of poor outcome from childhood bacterial meningitis. In turn, the factors associated with the admission GCS are less known. Our aim was to identify them, both for clinical alerts of reserved prognosis and to find potential targets for intervention. METHODS: This study is a secondary analysis of data collected prospectively in Angola and in Latin America between 1996 and 2007. Children with bacterial meningitis were examined on hospital admission and their GCS was assessed using the age-adjusted scale...
March 21, 2024: Acta Paediatrica
https://read.qxmd.com/read/38508484/predictors-of-invasive-bacterial-infection-in-febrile-infants-aged-2-to-6-months-in-the-emergency-department
#2
JOURNAL ARTICLE
Rebecca S Green, Laura F Sartori, Todd A Florin, Paul L Aronson, Brian E Lee, James M Chamberlain, Kathryn M Hunt, Kenneth A Michelson, Lise E Nigrovic
Our goal was to identify predictors of invasive bacterial infection (ie, bacteremia and bacterial meningitis) in febrile infants aged 2 to 6 months. In our multicenter retrospective cohort, older age and lower temperature identified infants at low risk for invasive bacterial infection who could safely avoid routine testing.
March 18, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38504350/fulminant-coronavirus-disease-2019-meningitis-in-iranian-infants-a%C3%A2-case-series
#3
JOURNAL ARTICLE
Shahla Afsharpayman, Sedigheh Madani, Susan Amirsalari, Nooradin Momeni, Mohammad Torkaman, Fatemeh Beiraghdar, Zohreh Kavehmanesh, Zahra Hosseininezhad
BACKGROUND: Pediatric coronavirus disease 2019 infection usually presents with respiratory and gastrointestinal symptoms. In this report we present fulminant meningitis as the main presentation of coronavirus disease 2019 without major signs and symptoms of other organs' involvement in 3 infants. CASES: The first case was a 4 months Iranian male infant with fulminant meningitis as the main presentation of coronavirus disease 2019 without other organ involvement...
March 20, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38493326/clinical-characteristics-etiology-and-outcomes-of-hypothermia-in-well-appearing-children-referred-to-the-emergency-department
#4
JOURNAL ARTICLE
Lea Ohana Sarna, Dina Qaraen Saloni, Mevaseret Avital, Naama Pines, Itai Gross, Giora Wieser, Saar Hashvya
BACKGROUND: Hypothermia, as a sign of serious bacterial infection (SBI) in children and infants older than 90 days is poorly characterized, especially in the post-pneumococcal vaccine era. OBJECTIVES: To assess the prevalence of SBI in children and infants presenting to the pediatric emergency department (PED) with reported or documented hypothermia. METHODS: Retrospective data analysis was conducted of all well-appearing children aged 0-16 years who presented with a diagnosis of hypothermia at two tertiary PEDs from 2010 to 2019...
March 2024: Israel Medical Association Journal: IMAJ
https://read.qxmd.com/read/38482535/outcomes-symptomatology-and-mortality-of-children-presenting-with-bacterial-meningitis-at-allied-hospitals-of-rawalpindi-medical-university-pakistan-a-cross-sectional-study
#5
JOURNAL ARTICLE
Muhammad Zarak Khan, Aiman Waheed, Faizan Fazal, Shahrukh Ahmad Khan, Ehsan Ahmad, Sanan Rasheed, Talha Ijaz, Areesha Abid, Saima Ambreen, Bilal Haider Malik
Introduction Bacterial meningitis (BM) is a neurologic emergency mainly affecting children under the age of two. Clinical symptoms are rarely evident in children, thus making a diagnosis is a challenge. Antibiotic therapy should be started timely to ensure the avoidance of significant morbidity and mortality. This study aims to assess the outcomes, mortality, and symptomatology of children presenting with BM in allied hospitals of Rawalpindi Medical University, Pakistan. Methods It is a cross-sectional study employing a sample size of 201, conducted at the Allied Hospitals of Rawalpindi Medical University, Pakistan from a period of January 2023 to August 2023...
March 2024: Curēus
https://read.qxmd.com/read/38481522/risk-of-serious-bacterial-infections-in-pediatric-patients-with-hyperpyrexia
#6
JOURNAL ARTICLE
Sofia Rachad, Dane Nickel, Fiona Berry, Meghan Goddard, Ayesha Khan, Natalie Muratori, Saul Hymes, Ashar Ata, Christopher Woll
OBJECTIVES: Hyperpyrexia has been associated with a greater prevalence of bacterial infections in the pediatric population, which prior to routine childhood vaccinations, has led to invasive testing and empiric antibiotic use for urinary tract infections, bacterial pneumonia, bacteremia, and bacterial meningitis. Since the implementation of routine childhood vaccinations, the prevalence of serious bacterial infections (SBIs) has declined. This study aims to determine if there is an association between hyperpyrexia and serious bacterial infections in well-appearing febrile pediatric patients presenting to the emergency department (ED)...
April 2024: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/38464900/practice-patterns-in-pediatric-infectious-encephalopathy-in-four-centers-in-africa
#7
JOURNAL ARTICLE
Tigist Bacha, Alexandra Obremskey, Jessica Buxton, Ericka L Fink, Amelie von Saint Andre-von Arnim, Madiha Raees
INTRODUCTION: Infectious encephalopathy (IE), including meningitis, infectious encephalitis, and cerebral abscess, remains prevalent and carries high mortality and morbidity in children, especially in low and middle income countries (LMIC). This study aims to describe the usual care and outcomes of pediatric IE in four LMIC hospitals in sub-Saharan Africa to support evidence-based care guideline development. METHODS: This is a secondary analysis of the Prevalence of Acute Critical Neurological disease in children: A Global Epidemiological Assessment-Developing Countries study, a 4-week, prospective, observational study in children (1 week to 17 years) with IE presenting to referral hospitals in Ethiopia, Kenya, Rwanda, and Ghana...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38463079/an-unusual-imaging-presentation-of-pediatric-bacterial-meningoencephalitis-a-case-report-study
#8
Maryam Kachuei, Ramin Zare, Shirin Sayyahfar, Mitra Khalili, Hamidreza Movahedi, Mobin Naghshbandi, Shayan Eghdami
BACKGROUND: Bacterial meningoencephalitis is a serious infection affecting the brain and its surrounding membranes. While imaging studies play a crucial role in diagnosing this condition, the typical radiological findings are well-documented. However, this case report describes an unusual imaging presentation that deviates from the expected patterns, emphasizing the need for awareness of such variations. CASE PRESENTATION: A 7-year-old female with no prior medical history was referred to our hospital with fever, seizure, and loss of Consciousness...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38461760/efficacy-and-safety-of-ketamine-for-pediatric-and-adolescent-super-refractory-status-epilepticus-and-the-effect-of-cerebral-inflammatory-conditions
#9
JOURNAL ARTICLE
Ichiro Kuki, Takeshi Inoue, Masataka Fukuoka, Megumi Nukui, Hideo Okuno, Kiyoko Amo, Yasunori Otsuka, Junichi Ishikawa, Hiroshi Rinka, Atushi Ujiro, Masao Togawa, Masashi Shiomi, Shin Okazaki
OBJECTIVE: To investigate the short-term benefits and adverse effects of ketamine in the treatment of pediatric and adolescent super-refractory status epilepticus (SRSE), with a focus on the inflammatory etiology. METHODS: This retrospective observational cohort study included a consecutive series of 18 pediatric to adolescent patients with SRSE admitted between 2008 and 2023 and treated with ketamine. Seizure frequency per hour before and after ketamine administration and response rate were calculated...
March 6, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38410352/neurological-manifestations-of-scrub-typhus-infection-in-pediatric-patient-a-case-report-from-tertiary-care-hospital-in-central-india
#10
Priyanka Singh, Vishal Shete, Abhijit Choudhary, Neeta Gade, Meena Mishra
Scrub typhus is a neglected tropical bacterial disease endemic in central India which can manifest as meningitis/meningoencephalitis in children. It is difficult to diagnose clinically, especially in the absence of eschar or rash. Scrub typhus is seldom considered the differential diagnosis of meningitis in the Indian subcontinent. Appropriate investigations can lead to early detection of infection and initiation of correct antibiotic treatment leading to better patient prognosis even when features of meningitis supervene...
January 2024: Curēus
https://read.qxmd.com/read/38401054/decrease-in-rates-of-hearing-loss-from-pediatric-bacterial-meningitis-over-time-a-database-review
#11
JOURNAL ARTICLE
Sarah Ann Gitomer, Juri Boguniewicz, Suhong Tong, Drew C Gottman, Scott Hirsch, Brian William Herrmann
OBJECTIVES: Bacterial meningitis is a leading cause of acquired sensorineural hearing loss (SNHL). Treatment and prevention of bacterial meningitis have improved over time, but rates of neurologic complications have not been recently studied. The objective here is to present an updated population-based review of hearing loss as a sequela of bacterial meningitis. METHODS: A retrospective cohort study was conducted between 2010 and 2022 of children discharged with bacterial meningitis, using the Pediatric Health Information System's (PHIS) database...
February 24, 2024: Laryngoscope
https://read.qxmd.com/read/38361682/ventriculoperitoneal-shunt-migration-into-the-transverse-colon-a-case-report
#12
Ahmad R Awwad, Manar S H Odeh, Diya Asad, Basel Y M H Abu Rmeileh, Aya M M Dweik, Saja N M Baraka, Malek A F Karami, Iyas I M Awad, Afnan W M Jobran
A ventriculoperitoneal (VP) shunt is a connection between the cerebral ventricles and the peritoneal cavity. One of the rare complications of this procedure is shunt migration and perforation of the bowel. Our case report presents the case of a 19-month-old male patient who underwent VP shunt insertion due to hydrocephalus at the age of 8 months. He suffered from two episodes of bacterial meningitis at the ages of 11 and 15 months, requiring hospital admission. The patient's parents brought him to the emergency department after noticing a blood-stained diaper and seeing a part of the shunt extruding from the anal opening...
January 2024: Curēus
https://read.qxmd.com/read/38359336/clinical-picture-and-risk-factors-for-poor-outcome-in-streptococcus-pneumoniae-meningitis-of-childhood-on-three-continents
#13
JOURNAL ARTICLE
Pinja-Liisa Mbakwe, Irmeli Roine, Manuel Leite Cruzeiro, Markku Kallio, Heikki Peltola, Tuula Pelkonen
BACKGROUND: Streptococcus pneumoniae meningitis (SpM) remains a major health burden worldwide, particularly in low- and middle-income countries. Identifying the patients at highest risk for mortality and disabling sequelae may reveal potentially avoidable predisposing factors and identify patients most in need of intensive care. We searched for factors that do not require laboratory facilities. METHODS: This study was a secondary analysis of prospectively collected data from 5 clinical trials of childhood bacterial meningitis on 3 continents between 1984 and 2017...
February 7, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38345811/emergency-department-volume-and-delayed-diagnosis-of-serious-pediatric-conditions
#14
JOURNAL ARTICLE
Kenneth A Michelson, Chris A Rees, Todd A Florin, Richard G Bachur
IMPORTANCE: Diagnostic delays are common in the emergency department (ED) and may predispose to worse outcomes. OBJECTIVE: To evaluate the association of annual pediatric volume in the ED with delayed diagnosis. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study included all children younger than 18 years treated at 954 EDs in 8 states with a first-time diagnosis of any of 23 acute, serious conditions: bacterial meningitis, compartment syndrome, complicated pneumonia, craniospinal abscess, deep neck infection, ectopic pregnancy, encephalitis, intussusception, Kawasaki disease, mastoiditis, myocarditis, necrotizing fasciitis, nontraumatic intracranial hemorrhage, orbital cellulitis, osteomyelitis, ovarian torsion, pulmonary embolism, pyloric stenosis, septic arthritis, sinus venous thrombosis, slipped capital femoral epiphysis, stroke, or testicular torsion...
February 12, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38332970/management-of-well-appearing-febrile-young-infants-aged-%C3%A2-90-days
#15
REVIEW
Brett Burstein, Marie-Pier Lirette, Carolyn Beck, Laurel Chauvin-Kimoff, Kevin Chan
The evaluation and management of young infants presenting with fever remains an area of significant practice variation. While most well-appearing febrile young infants have a viral illness, identifying those at risk for invasive bacterial infections, specifically bacteremia and bacterial meningitis, is critical. This statement considers infants aged ≤90 days who present with a rectal temperature ≥38.0°C but appear well otherwise. Applying recent risk-stratification criteria to guide management and incorporating diagnostic testing with procalcitonin are advised...
February 2024: Paediatrics & Child Health
https://read.qxmd.com/read/38323267/case-report-two-cases-of-multiples-and-atypical-dermal-sinus-tracts
#16
Peter Spazzapan, Dominic N P Thompson
Dermal sinus tracts (DSTs) are congenital lesions that connect the cutaneous ectoderm with the underlying neuroectodermal tissues. They are typically midline, solitary lesions. Multiple, and atypically located DSTs have been only rarely described. We present two cases of multiple and laterally located DSTs. The first presented with bacterial meningitis and two tracts in the right buttock, one of which entered the spinal canal through the S3 neural foramen. The second child had three midline lumbar DSTs, one subcutaneous dermoid cyst and one intradural epidermoid cyst...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38312010/predicting-serious-bacterial-infections-among-hypothermic-infants-in-the-emergency-department
#17
JOURNAL ARTICLE
Nathan M Money, Yu Hsiang J Lo, Hannah King, Christopher Graves, Jamie Lynn Holland, Alexander Rogers, Andrew N Hashikawa, Andrea T Cruz, Douglas J Lorenz, Sriram Ramgopal
BACKGROUND: There is insufficient evidence to guide the initial evaluation of hypothermic infants. We aimed to evaluate risk factors for serious bacterial infections (SBI) among hypothermic infants presenting to the emergency department (ED). METHODS: We conducted a multicenter case-control study among hypothermic (rectal temperature <36.5°C) infants ≤90 days presenting to the ED who had a blood culture collected. Our outcome was SBI (bacteremia, bacterial meningitis, and/or urinary tract infection)...
February 5, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38312006/performance-of-febrile-infant-decision-tools-on-hypothermic-infants-evaluated-for-infection
#18
JOURNAL ARTICLE
Kathryn Westphal, Hania Adib, Vignesh Doraiswamy, Kevin Basiago, Jennifer Lee, Sumeet L Banker, John Morrison, Saylor McCartor, Stephanie Berger, Erinn O Schmit, Annalise Van Meurs, Meredith Mitchell, Clifton Lee, Julie K Wood, Lauren G Tapp, Deborah Kunkel, Elizabeth E Halvorson, Nicholas M Potisek
BACKGROUND: Given the lack of evidence-based guidelines for hypothermic infants, providers may be inclined to use febrile infant decision-making tools to guide management decisions. Our objective was to assess the diagnostic performance of febrile infant decision tools for identifying hypothermic infants at low risk of bacterial infection. METHODS: We conducted a secondary analysis of a retrospective cohort study of hypothermic (≤36.0 C) infants ≤90 days of age presenting to the emergency department or inpatient unit among 9 participating sites between September 1, 2016 and May 5, 2021...
February 5, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38308446/audit-of-adherence-to-international-guidelines-idsa-in-the-treatment-of-infectious-meningitis-in-pediatric-patients-in-jordan
#19
JOURNAL ARTICLE
Dina Mohialdin, Rana Abu-Farha, Rama ALkhawaldeh, Mohammed Zawiah, Khawla Abu Hammour
Objective: This study aims to audit the adherence of Jordanian medical care staff to the guidelines provided by the Infectious Disease Society of America (IDSA) for managing pediatric patients admitted with suspected cases of meningitis. Methods: A retrospective observational study was conducted at Jordan University Hospital (JUH). All pediatric patients admitted to JUH with suspected meningitis between January 1, 2019, and September 30, 2022, who underwent Cerebrospinal Fluid (CSF) and blood culture tests were recruited in this study unless there was a reason for exclusion...
February 2, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38304639/proportion-of-successful-lumbar-punctures-in-infants-younger-than-three-months
#20
JOURNAL ARTICLE
Rei Miyake, Kento Ikegawa, Hiroshi Hataya, Yoshihiko Morikawa
It is important to perform lumbar punctures (LPs) without a single traumatic tap in infants younger than three months owing to the risk of serious complications. The proportion of LPs in which clear cerebrospinal fluid (CSF) was obtained has been previously reported, but some of the procedures involved a traumatic tap. The present study aimed to identify the proportion of LPs in which clear CSF was obtained without a single traumatic tap and the factors associated with successful LPs in infants younger than three months...
January 2024: Curēus
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