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pediatric bacterial meningitis

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https://www.readbyqxmd.com/read/29808135/uncommon-infections-in-children-suggest-underlying-immunodeficiency-a-case-of-infective-endocarditis-in-a-3-year-old-male
#1
Aisha Shakoor, Ahmed El-Isa, Elizabeth Kinsella, Ryan Halas, Andrey Leonov
Infective endocarditis (IE) results from bacterial or fungal infection and is associated with significant morbidity and mortality. Several known risk factors exist for endocarditis, and 90% of pediatric cases have an underlying structural or congenital heart disease or prosthetic heart valve. Literature on IE in previously healthy children is relatively sparse, and the pathogenesis and underlying risk factors remain mostly unknown. Our patient was a 3-year-old male with a unique presentation of IE. His lack of structural and congenital risk factors for endocarditis prompted further workup, and labs were consistent with insufficient immunoglobulin, suggesting a primary immunodeficiency (PAD)...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29784512/epidemiology-and-etiology-of-invasive-bacterial-infection-in-infants-%C3%A2-60-days-old-treated-in-emergency-departments
#2
Christopher Woll, Mark I Neuman, Christopher M Pruitt, Marie E Wang, Eugene D Shapiro, Samir S Shah, Russell J McCulloh, Lise E Nigrovic, Sanyukta Desai, Adrienne G DePorre, Rianna C Leazer, Richard D Marble, Fran Balamuth, Elana A Feldman, Laura F Sartori, Whitney L Browning, Paul L Aronson
OBJECTIVES: To help guide empiric treatment of infants ≤60 days old with suspected invasive bacterial infection by describing pathogens and their antimicrobial susceptibilities. STUDY DESIGN: Cross-sectional study of infants ≤60 days old with invasive bacterial infection (bacteremia and/or bacterial meningitis) evaluated in the emergency departments of 11 children's hospitals between July 1, 2011 and June 30, 2016. Each site's microbiology laboratory database or electronic medical record system was queried to identify infants from whom a bacterial pathogen was isolated from either blood or cerebrospinal fluid...
May 18, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29669791/retrospective-evaluation-of-infants-aged-1-60-days-with-residual-csf-tested-using-the-filmarray%C3%A2-meningitis-encephalitis-me-panel
#3
Anne J Blaschke, Kristen M Holmberg, Judy A Daly, Amy L Leber, Jennifer Dien Bard, Ernest K Korgenski, Kevin M Bourzac, Kristen J Kanack
In pediatric practice it is common for infants under 2 months of age to undergo evaluation for sepsis when they are ill, often including lumbar puncture (LP) to assess for central nervous system (CNS) infection. The FilmArray® Meningitis/Encephalitis (ME) Panel is a newly approved test for rapid identification of CNS pathogens. Our objective was to study the epidemiology of CNS infection in young infants and the potential impact of rapid multiplex PCR on their care.A performance evaluation of the FilmArray ME Panel was conducted from 2/2014-9/2014 at 11 sites...
April 18, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29540454/one-year-in-the-life-of-a-rapid-syndromic-panel-for-meningitis-encephalitis-a-pediatric-tertiary-care-facility-s-experience
#4
Samia N Naccache, Maryann Lustestica, Margil Fahit, Javier Mestas, Jennifer Dien Bard
Early establishment of infectious processes allows for expedited clinical management of meningitis and encephalitis. The FilmArray meningitis/encephalitis (FA-M/E) panel provides rapid detection of potential pathogens associated with encephalitis/meningitis in both immunocompetent and compromised patients. Here, we conducted a 1-year review of the performance of the FA-M/E panel at a tertiary care children's hospital. Two hundred sixty-five samples from 251 patients were tested. We found 87.25% (219/251) were negative, 9...
May 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29512478/pediatric-acute-severe-neurologic-illness-and-injury-in-an-urban-and-a-rural-hospital-in-the-democratic-republic-of-the-congo
#5
Taty Tshimangani, Jean Pongo, Joseph Bodi Mabiala, Marcel Yotebieng, Nicole F O'Brien
Empirical knowledge suggests that acute neurologic disorders are common in sub-Saharan Africa, but studies examining the true burden of these diseases in children are scarce. We performed this prospective, observational study to evaluate the prevalence, clinical characteristics, treatment approaches, and outcomes of children suffering acute neurologic illness or injury (ANI) in an urban and rural site in the Democratic Republic of the Congo. Over 12 months, 471 out of 6,563 children admitted met diagnostic criteria for ANI, giving a hospital-based prevalence of 72/1,000 admissions...
May 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29490126/corticosteroid-use-in-management-of-pediatric-emergency-conditions
#6
Asalim Thabet, Tyler Greenfield, Richard M Cantor
Corticosteroids have been used for over half a century to treat various inflammatory disorders; however, their use in many pediatric conditions remains controversial. This issue reviews evidence on corticosteroid treatment in acute asthma exacerbations, croup, acute pharyngitis, anaphylaxis, acute spinal injury, and bacterial meningitis. While corticosteroids are clearly indicated for management of asthma exacerbations and croup, they are not universally recommended for potential spinal cord injury. Due to insufficient data or conflicting data, corticosteroids may be considered in children with acute pharyngitis, anaphylaxis, and bacterial meningitis...
March 2018: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/29490125/corticosteroid-use-in-management-of-pediatric-emergency-conditions-digest
#7
Asalim Thabet, Tyler Greenfield, Richard M Cantor, Bryan Wilson
Corticosteroids have been used for over half a century to treat various inflammatory disorders; however, their use in many pediatric conditions remains controversial. This issue reviews evidence on corticosteroid treatment in acute asthma exacerbations, croup, acute pharyngitis, anaphylaxis, acute spinal injury, and bacterial meningitis. While corticosteroids are clearly indicated for management of asthma exacerbations and croup, they are not universally recommended for potential spinal cord injury. Due to insufficient data or conflicting data, corticosteroids may be considered in children with acute pharyngitis, anaphylaxis, and bacterial meningitis...
March 1, 2018: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/29461450/utility-of-the-performance-of-lumbar-puncture-for-febrile-children-with-status-epilepticus-in-the-bacterial-conjugate-vaccine-era
#8
Haro Kaoru, Ryota Igarashi, Takayuki Hoshina, Masumi Kojiro, Koichi Kusuhara
BACKGROUND: The necessity of lumbar puncture for the differentiation of central nervous system (CNS) infection in children with febrile status epilepticus (FSE) remains controversial. The aim of the present study is to investigate the diagnostic necessity of lumbar puncture for children with FSE after the introduction of bacterial conjugate vaccines into the infant immunization program. METHODS: Our retrospective cohort study was performed in children aged 6 to 60 months who were admitted to the pediatric ward at Kitakyushu General Hospital from January 1, 2011 to December 31, 2015 for seizures with fever...
February 15, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29456197/clinical-usefulness-and-accuracy-of-polymerase-chain-reaction-in-the-detection-of-bacterial-meningitis-agents-in-pediatric-cerebrospinal-fluid
#9
M Nour, A Alaidarous
Bacterial meningitis poses enormous healthcare challenges due to a high mortality, morbidity and sequelae. Neisseria (N.) meningitidis, Haemophilus (H.) influenzae, Streptococcus (S.) pneumoniae and S. agalactiae remain among the most prevalent infectious agents that cause bacterial meningitis in children. The objective of this study was the simultaneous detection of these pathogens in suspected cerebrospinal fluid (CSF) by using multiplex polymerase chain reaction (mPCR) and compare PCR results with standard diagnostics currently used in clinical practice...
March 2018: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29433694/antibioth%C3%A3-rapie-des-infections-n%C3%A3-onatales-bact%C3%A3-riennes-pr%C3%A3-coces-chez-les-nouveau-n%C3%A3-s-n%C3%A3-s-%C3%A3-partir-de-34-semaines-d%C3%A2-am%C3%A3-norrh%C3%A3-e
#10
O Romain
All newborns superior to 34 weeks of gestationnal age (GA) are concerned by these guidelines of the French Society of Neonatology and the French Society of Pediatrics. Only newborns at risk of Early-Onset Neonatal Bacterial Infection who are clinically symptomatic have to be treated with probabilistic antibiotherapy treatment. The antibiotic combination of choice is amoxicillin + gentamicin. The two exceptions that justify dual therapy with Cefotaxime and Gentamicin are the bacteriological documentation of Escherichia coli and/or the presence of clinical signs of severity...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29406479/application-of-the-rochester-criteria-to-identify-febrile-infants-with-bacteremia-and-meningitis
#11
Paul L Aronson, Russell J McCulloh, Joel S Tieder, Lise E Nigrovic, Rianna C Leazer, Elizabeth R Alpern, Elana A Feldman, Fran Balamuth, Whitney L Browning, Mark I Neuman
OBJECTIVES: The Rochester criteria were developed to identify febrile infants aged 60 days or younger at low-risk of bacterial infection and do not include cerebrospinal fluid (CSF) testing. Prior studies have not specifically assessed criteria performance for bacteremia and bacterial meningitis (invasive bacterial infection). Our objective was to determine the sensitivity of the Rochester criteria for detection of invasive bacterial infection. METHODS: Retrospective cohort study of febrile infants aged 60 days or younger with invasive bacterial infections evaluated at 8 pediatric emergency departments from July 1, 2012, to June 30, 2014...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29299893/response-of-vancomycin-according-to-steroid-dosage-in-pediatric-patients-with-culture-proven-bacterial-meningitis
#12
Shin Ae Lee, Jin Kyu Kim, Dae Sun Jo, Sun Jun Kim
BACKGROUND: This study aimed to evaluate the efficacy of combined vancomycin and steroid therapy for the treatment of culture-proven bacterial meningitis in pediatric patients. MATERIALS AND METHODS: We identified a total of 86 pediatric patients with culture-positive cerebrospinal fluid who were treated at our facility between 2005 and 2015. Ten of these patients (5 boys and 5 girls) received first-line treatment with vancomycin as the initial form of therapy. All cultured bacteria were sensitive to vancomycin...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29290234/bacterial-meningitis-antibiotic-treatment
#13
R Cohen, J Raymond, L Hees, D Pinquier, E Grimprel, C Levy
The implementation of pneumococal conjugate vaccines (PCVs) 7 then 13 valent (Prevenar13®) in 2010-2011 has significantly changed the profile of pneumococcal meningitis. Since 3 years, the National Pediatric Meningitis Network of the Pediatric Infectious Disease Group (GPIP) and the National Reference Centre of Pneumococci have reported no cases of meningitis due to pneumococcus resistant to third-generation cephalosporins (3GC): cefotaxime or ceftriaxone. In the light of these new data, vancomycin should no longer be prescribed at the initial phase of pneumococcal meningitis treatment (confirmed or only suspected) and this antibiotic should only be added when 3GC minimum inhibitory concentration of the strain isolated is greater than 0...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29216848/anterior-sacral-meningocele-infected-with-fusobacterium-in-a-patient-with-recently-diagnosed-colorectal-carcinoma-a-case-report
#14
Anne K Braczynski, Marc A Brockmann, Torben Scholz, Jan-Philipp Bach, Jörg B Schulz, Simone C Tauber
BACKGROUND: Anterior sacral meningoceles are rare, and usually occur with other malformations of the posterior lower spine. While these are more frequently reported in pediatric cohorts, we report a case in an elderly woman. CASE PRESENTATION: We report on a 71 year-old woman with a recently diagnosed colorectal adenocarcinoma who presented with a severe bacterial meningitis. The cerebrospinal fluid cell count revealed a pleocytosis of 80,000 cells/μl and a severe disturbance of the blood-brain-barrier...
December 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29165513/-a-five-year-experience-with-zoonotic-salmonella-at-a-pediatric-reference-centre
#15
Patricia Barrios, Federica Badía, Valentina Misa, M Inés Mota, Arací Martínez, Hebert Mariño, Gabriela Algorta, Javier Prego, M Catalina Pírez
BACKGROUND: Salmonella can cause asymptomatic infections, diarrhea, bacteremia and focal infections such as meningitis and osteomyelitis. AIM: To describe clinical and microbiological aspects of infections by Salmonella spp. in children in a pediatric referral hospital: Centro Hospitalario Pereira Rossell, in Montevideo, Uruguay. MATERIALS AND METHODS: Descriptive and retrospective study of 46 patients, from which Salmonella spp was isolated between January 1, 2005 and December 31, 2010...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29035302/oligoarticular-hemarthroses-and-osteomyelitis-complicating-pasteurella-meningitis-in-an-infant
#16
Charles Nathan Nessle, Allison K Black, Justin Farge, Victoria A Statler
A 5-month-old previously healthy female presented with a one-week history of fever and increased fussiness. Her presentation revealed an ill-appearing infant with an exam and cerebrospinal fluid (CSF) studies concerning bacterial meningitis; CSF cultures grew Pasteurella multocida . Additionally, brain magnetic resonance imaging (MRI) demonstrated cervical osteomyelitis. Despite multiple days of antibiotic therapy, she remained febrile with continued pain; MRI showed oligoarticular effusions, and aspiration of these joints yielded bloody aspirates...
October 16, 2017: Children
https://www.readbyqxmd.com/read/28988964/epidemiology-of-bacteremia-in-febrile-infants-aged-60-days-and-younger
#17
Elizabeth C Powell, Prashant V Mahajan, Genie Roosevelt, John D Hoyle, Rajender Gattu, Andrea T Cruz, Alexander J Rogers, Shireen M Atabaki, David M Jaffe, T Charles Casper, Octavio Ramilo, Nathan Kuppermann
STUDY OBJECTIVE: To describe the current epidemiology of bacteremia in febrile infants 60 days of age and younger in the Pediatric Emergency Care Applied Research Network (PECARN). METHODS: We conducted a planned secondary analysis of a prospective observational study of febrile infants 60 days of age and younger presenting to any of 26 PECARN emergency departments (2008 to 2013) who had blood cultures obtained. We excluded infants with significant comorbidities or critically ill appearance...
February 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28892537/accuracy-of-complete-blood-cell-counts-to-identify-febrile-infants-60-days-or-younger-with-invasive-bacterial-infections
#18
Andrea T Cruz, Prashant Mahajan, Bema K Bonsu, Jonathan E Bennett, Deborah A Levine, Elizabeth R Alpern, Lise E Nigrovic, Shireen M Atabaki, Daniel M Cohen, John M VanBuren, Octavio Ramilo, Nathan Kuppermann
Importance: Clinicians often risk stratify young febrile infants for invasive bacterial infections (IBIs), defined as bacteremia and/or bacterial meningitis, using complete blood cell count parameters. Objective: To estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with IBIs. Design, Setting, and Participants: Planned secondary analysis of a prospective observational cohort study comprising 26 emergency departments in the Pediatric Emergency Care Applied Research Network from 2008 to 2013...
November 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28814616/the-yale-observation-scale-score-and-the-risk-of-serious-bacterial-infections-in-febrile-infants
#19
Lise E Nigrovic, Prashant V Mahajan, Stephen M Blumberg, Lorin R Browne, James G Linakis, Richard M Ruddy, Jonathan E Bennett, Alexander J Rogers, Leah Tzimenatos, Elizabeth C Powell, Elizabeth R Alpern, T Charles Casper, Octavio Ramilo, Nathan Kuppermann
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile infants ≤60 days of age with and without serious bacterial infections (SBIs). METHODS: We performed a planned secondary analysis of a prospective cohort of non-critically ill, febrile, full-term infants ≤60 days of age presenting to 1 of 26 participating emergency departments in the Pediatric Emergency Care Applied Research Network...
June 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/28803838/current-epidemiology-of-resistance-among-gram-negative-bacilli-in-paediatric-patients-in-turkey
#20
Kubra Aykac, Yasemin Ozsurekci, Sevgen Tanır Basaranoglu, Mustafa Senol Akin, Ali Bulent Cengiz, Asiye Bicakcigil, Banu Sancak, Ates Kara, Mehmet Ceyhan
OBJECTIVES: The increasing incidence of infections caused by drug-resistant Gram-negative organisms has led to a re-emergence worldwide. This study attempted to investigate the changes in resistance of Gram-negative bacteria to different classes of antibiotics and the treatment options for invasive infections. METHODS: A retrospective study was performed between January 2012 and January 2017 in a Turkish tertiary care university hospital. A total of 302 patients with Gram-negative bacteraemia (n=274; 90...
December 2017: Journal of Global Antimicrobial Resistance
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