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https://www.readbyqxmd.com/read/28329542/silicone-granulomas-with-ulcers
#1
Lisa R Rothman, Randie H Kim, Shane A Meehan, Alisa Femia
We present a 42-year-old transgender womanwith woody induration over her buttocks andlower extremities as well as persistent ulcers of thebuttocks. The lesions developed ten years prior to herpresentation and approximately five years after shereceived illegal silicone injections to her buttocks.Histopathologic examination was consistent witha silicone granuloma. Silicone granuloma is a notan uncommon side effect of silicone injections andmore often occurs when the filler is administeredby non-physician practitioners, as is the case in thispatient...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329529/concurrent-pyogenic-granuloma-and-bullous-impetigo-of-a-pregnant-woman-s-finger
#2
Rosie Qin, Philip R Cohen
BACKGROUND: Bullous impetigo is a superficial skininfection caused by Staphylococcus aureus (S.aureus). Pyogenic granuloma is a common benigntumor frequently associated with prior trauma.Bullous impetigo and pyogenic granuloma may occurin pregnant women. PURPOSE: The features of a pregnant womanwith pyogenic granuloma and bullous impetigoconcurrently present in a lesion on her finger aredescribed. METHODS: PubMed was used to search the followingterms: bullous impetigo, pregnancy, and pyogenicgranuloma...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28322774/development-and-reliability-of-the-new-endoscopic-virtual-chromoendoscopy-score-the-picasso-score-paddington-international-virtual-chromoendoscopy-score-in-ulcerative-colitis
#3
Marietta Iacucci, Marco Daperno, Mark Lazarev, Razvan Arsenascu, Gian Eugenio Tontini, Oluseyi Akinola, Xianyong Sean Gui, Vincenzo Villanacci, Martin Goetz, Mark Lowerison, Brendan Cord Lethebe, Maurizio Vecchi, Helmut Neumann, Subrata Ghosh, Raf Bisschops, Ralf Kiesslich
INTRODUCTION: Endoscopic inflammation and healing are important therapeutic endpoints in ulcerative colitis (UC). We developed and validated a new electronic virtual chromoendoscopy (EVC) score that could reflect the full spectrum of mucosal and vascular changes including mucosal healing in UC. METHODS: Eight participants reviewed a 60-minute training module outlining the three different i-SCAN modes demonstrating the entire spectrum of inflammatory mucosal and vascular changes in UC...
March 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28320201/analysis-of-never-events-following-adult-cardiac-surgical-procedures-in-the-united-states
#4
Michael P Robich, Brianna M Krafcik, Nishant K Shah, Alik Farber, Denis Rybin, Jeffrey J Siracuse
BACKGROUND: This study was conducted to determine the risk factors, nature, and outcomes of "never events" following open adult cardiac surgical procedures. Understanding of these events can reduce their occurrence, and thereby improve patient care, quality metrics, and cost reduction. METHODS: "Never events" for patients included in the Nationwide Inpatient Sample who underwent coronary artery bypass graft, heart valve repair/replacement, or thoracic aneurysm repair between 2003-2011 were documented...
March 16, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28318554/decubitus-ulcers-in-patients-undergoing-vascular-operations-do-not-influence-mortality-but-affect-resource-utilization
#5
J Hunter Mehaffey, Amani D Politano, Castigliano M Bhamidipati, Margaret C Tracci, Kenneth J Cherry, John A Kern, Irving L Kron, Gilbert R Upchurch
BACKGROUND: While it is anticipated that decubitus ulcers are detrimental to outcomes after vascular operations, the contemporary influence of perioperative decubitus ulcers in vascular surgery remains unknown. METHODS: Using the National Impatient Survey, all adult patients who underwent vascular operation were selected. Patients were stratified by the presence or absence (non-decubitus ulcers) of decubitus ulcer. Case-mix adjusted hierarchical mixed-models examined in-hospital mortality, the occurrence of any complication, and discharge disposition...
March 17, 2017: Surgery
https://www.readbyqxmd.com/read/28315280/beyond-white-light-optical-enhancement-in-conjunction-with-magnification-colonoscopy-for-the-assessment-of-mucosal-healing-in-ulcerative-colitis
#6
Marietta Iacucci, Ralf Kiesslich, Xianyong Gui, Remo Panaccione, Joan Heatherington, Oluseyi Akinola, Subrata Ghosh
Background and study aim The I-SCAN optical enhancement (OE) system with magnification is a recently introduced combination of optical and digital electronic virtual chromoendoscopy, which enhances mucosal and vascular details. The aim of this pilot study was to investigate the use of I-SCAN OE in the assessment of inflammatory changes in ulcerative colitis (UC). Patients and methods A total of 41 consecutive patients with UC and 9 control patients were examined by I-SCAN OE (Pentax Medical, Tokyo, Japan)...
March 17, 2017: Endoscopy
https://www.readbyqxmd.com/read/28301356/local-heating-test-for-detection-of-microcirculation-abnormalities-in-patients-with-diabetes-related-foot-complications
#7
Aleksey Parshakov, Nadezhda Zubareva, Sergey Podtaev, Peter Frick
OBJECTIVE: In this study, authors used a wavelet analysis of skin temperature (WAST) to assess the mechanisms of microvascular tone regulation during the local heating test in patients with diabetic foot syndrome (DFS). PARTICIPANTS: The participants included control subjects and 36 hospitalized patients with DFS between 52 and 79 years old (68 ± 8 years old). They were distributed among 5 groups: 15 control subjects, 8 patients with DFS who did not develop ulcerative or necrotic disorders, 10 patients who developed the neuroischemic form of DFS complicated by foot ulceration, 12 patients with DFS complicated by toe necrosis, and 6 patients with DFS and foot gangrene...
April 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28296822/the-different-effects-of-vegfa121-and-vegfa165-on-regulating-angiogenesis-depend-on-phosphorylation-sites-of-vegfr2
#8
Wang Shiying, Sun Boyun, Yuan Jianye, Zhang Wanjun, Tao Ping, Lin Jiang, Hu Hongyi
The effects of VEGFA isoforms on the vascular permeability and structure are still unclear. In this study, we found that VEGFA121 and VEGFA165, 2 isoforms of VEGFA, exerted the opposing effects of antiangiogenesis and proangiogenesis on regulating vascular endothelia cells proliferation and tube formation. The 2 isoforms affected the protein expression of Ras-related protein 1-GTPase-activating protein 1 (Rap1GAP) and thrombospondin 1, 2 important signal molecules of Rap1GAP/thrombospondin 1 signal pathway in primary human umbilical vein endothelial cells by regulating 2 different phosphorylating sites of VEGFR2, Tyr(1175) and Tyr(1214)...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28296736/dermoscopic-features-of-livedoid-vasculopathy
#9
Stephen Chu-Sung Hu, Gwo-Shing Chen, Chi-Ling Lin, Yang-Chun Cheng, Yung-Song Lin
Livedoid vasculopathy (atrophie blanche) is a form of thrombotic vasculopathy. It is characterized by small ulcers that become crusted, and heal after several months to produce white atrophic scars. The most commonly affected sites are the lower legs, in particular the dorsum of the feet and ankles. To date, the dermoscopic features of livedoid vasculopathy have not been clearly described in the literature. In this observational study, we sought to evaluate the dermoscopic patterns of livedoid vasculopathy and determine whether the dermoscopic features are associated with certain histopathological characteristics...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28291582/sequential-nailfold-videocapillaroscopy-examinations-have-responsiveness-to-detect-organ-progression-in-systemic-sclerosis
#10
Jérôme Avouac, Gemma Lepri, Vanessa Smith, Elide Toniolo, Charlotte Hurabielle, Anaïs Vallet, Fazia Amrouche, André Kahan, Maurizio Cutolo, Yannick Allanore
OBJECTIVE: To determine the merit of nailfold videocapillaroscopy (NVC) to detect meaningful microvascular changes over time in patients with systemic sclerosis (SSc) and whether these changes are associated with overall disease progression and organ involvements. METHODS: A prospective cohort of 140 SSc patients was recruited over a 12-month period and was followed up on an annual basis for 3 years. Detailed NVC analysis was performed at inclusion and repeated annually...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28289465/an-exploration-of-diabetic-foot-screening-procedures-data-by-a-multiple-correspondence-analysis
#11
Vilma Urbančič Rovan, Jože Rovan
AIMS: Gangrene and amputation are among most feared complications of diabetes mellitus. Early detection of patients at high risk for foot ulceration can prevent foot complications. Regular foot screening (medical history, foot examination and classification into risk groups) was introduced at the out-patient diabetes clinic in Ljubljana in November 1996. We aimed to explore the relationships between the observed variables, check the appropriateness of the risk status classification and of the post-screening decisions...
March 1, 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28286751/new-delivery-systems-of-stem-cells-for-vascular-regeneration-in-ischemia
#12
REVIEW
Adegbenro Omotuyi John Fakoya
The finances of patients and countries are increasingly overwhelmed with the plague of cardiovascular diseases as a result of having to chronically manage the associated complications of ischemia such as heart failures, neurological deficits, chronic limb ulcers, gangrenes, and amputations. Hence, scientific research has sought for alternate therapies since pharmacological and surgical treatments have fallen below expectations in providing the desired quality of life. The advent of stem cells research has raised expectations with respect to vascular regeneration and tissue remodeling, hence assuring the patients of the possibility of an improved quality of life...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28284923/vascular-quadrilateral-space-syndrome-in-three-overhead-throwing-athletes-an-underdiagnosed-cause-of-digital-ischemia
#13
Johnathon Rollo, David Rigberg, Hugh Gelabert
Vascular quadrilateral space syndrome (vQSS) is an underdiagnosed cause of extremity ischemia, pain and paresthesia in overhand throwing athletes. The mechanism of vQSS is thought to result from repeated abduction and external rotation of the arm leading to a distraction injury of the posterior circumflex humoral artery (PCHA) as this courses through the quadrilateral space. This trauma may cause dissection and dissecting aneurysm formation. Thrombus from this arterial injury then embolizes down the arm resulting in the symptomatic presentation...
March 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28280910/-first-manifestation-of-leg-ulcers-analysis-of-data-from-1000-patients
#14
A Körber, F Jockenhöfer, W Sondermann, M Stoffels-Weindorf, J Dissemond
BACKGROUND: More than 1 million people in Germany suffer from leg ulcers. The diagnosis leg ulcer summarizes many different etiologies. The therapy of leg ulcers is an interdisciplinary and interprofessional challenge. Early identification of the cause of the leg ulcer and initiation of a causal therapy are essential for healing. OBJECTIVES: The aim of this study was to investigate the initial manifestation age of patients with causally associated leg ulcers. Afterwards we calculated the most common etiologies according to decade...
March 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28274750/the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-system-predicts-wound-healing-but-not-major-amputation-in-patients-with-diabetic-foot-ulcers-treated-in-a-multidisciplinary-setting
#15
Nestoras Mathioudakis, Caitlin W Hicks, Joseph K Canner, Ronald L Sherman, Kathryn F Hines, Ying W Lum, Bruce A Perler, Christopher J Abularrage
OBJECTIVE: The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) threatened limb classification has been shown to correlate well with risk of major amputation and time to wound healing in heterogeneous diabetic and nondiabetic populations. Major amputation continues to plague the most severe stage 4 WIfI patients, with 1-year amputation rates of 20% to 64%. Our aim was to determine the association between WIfI stage and wound healing and major amputation among patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting...
March 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28273973/evaluation-of-the-role-of-aldh1-as-cancer-stem-cell-marker-in-colorectal-carcinoma-an-immunohistochemical-study
#16
Nanis Shawky Holah, Hayam Abd-El-Samie Aiad, Nancy Yousif Asaad, Enas Abobakr Elkhouly, Ayat Gamal Lasheen
INTRODUCTION: Colorectal Carcinoma (CRC) is the third most commonly diagnosed cancer in males. Stem Cells (SC) may be involved in tumour growth, including colon cancer. Aldehyde Dehydrogenase 1 (ALDH1) is a detoxifying enzyme that might modulate SC proliferation. AIMS: To evaluate the immunohistochemical expression of ALDH1 as stem cell marker in the pathogenesis of colorectal carcinoma. MATERIALS AND METHODS: This retrospective study included 71 colorectal specimens (49 colorectal carcinoma, 13 adenoma and 9 normal cases) that were collected from Pathology Department, Faculty of Medicine, Menoufia University during the period from 2011 to 2015...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28272012/accuracy-of-the-ankle-brachial-index-in-the-assessment-of-arterial-perfusion-of-heel-pressure-injuries
#17
Amanda Crowell, Andrew J Meyr
BACKGROUND: The evaluation and treatment of heel pressure injuries are a significant and expensive sequela of the aging population. Although the workup of patients with lower extremity tissue loss usually involves an assessment of the arterial blood flow by means of noninvasive vascular testing, the results may be misleading in patients with heel pressure injuries when the ankle-brachial index (ABI) does not provide direct information about perfusion of the rearfoot. The objective of this retrospective, observational investigation was to determine if noninvasive vascular testing provides accurate and reliable results in patients with heel pressure injuries...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28266293/emergency-pancreatico-duodenectomy-with-superior-mesenteric-and-portal-vein-resection-and-reconstruction-using-a-gore-tex-vascular-graft
#18
Mihai Adrian Eftimie, Vasile Lungu, Marian Tudoroiu, Genady Vatachki, Severina Batca, Leonard David
Emergency pancreatico-duodenectomy(EPD) is a very rare procedure and few reports are present in medical literature. It is an uncommon approach, usually used for emergency surgical treatment of abdominal trauma that involves the head of the pancreas or the duodenum, but it is also a surgical tool for the treatment of ruptured aneurysms, bleeding pseudocysts, duodenal perforations, uncontrollable hemorrhage from ulcers and tumors, severe infectious complications of acute pancreatitis or endoscopic retrograde cholangiopancreatography related complications (1,2)...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28259681/stem-cell-laden-hyaluronic-acid-based-spongy-like-hydrogels-for-an-integrated-healing-of-diabetic-wounds-pathophysiologies
#19
Lucília Pereira da Silva, Tírcia Carlos Santos, Daniel Barreira Rodrigues, Rogério Pedro Pirraco, Mariana Teixeira Cerqueira, Rui Luís Reis, Vitor Manuel Correlo, Alexandra Pinto Marques
The correlation between the pathophysiologies of diabetic foot ulcerations is yet to be established and improved treatments are still required. We propose a strategy that directs inflammation, neo-vascularization and neo-innervation of diabetic wounds. Aiming to potentiate a relevant secretome for nerve regeneration, stem cells were pre-cultured in hyaluronic acid-based spongy-like hydrogels under neurogenic/standard media prior transplantation into diabetic mice full-thickness wounds. Acellular spongy-like hydrogels and empty wounds were used as controls...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28255738/cyclophosphamide-induced-stomach-and-duodenal-lesions-as-a-no-system-disturbance-in-rats-l-name-l-arginine-stable-gastric-pentadecapeptide-bpc-157
#20
Krešimir Luetic, Mario Sucic, Josipa Vlainic, Zeljka Belosic Halle, Dean Strinic, Tinka Vidovic, Franka Luetic, Marinko Marusic, Sasa Gulic, Tatjana Turudic Pavelic, Antonio Kokot, Ranka Serventi Seiwerth, Domagoj Drmic, Lovorka Batelja, Sven Seiwerth, Predrag Sikiric
We revealed a new point with cyclophosphamide (150 mg/kg/day intraperitoneally for 7 days): we counteracted both rat stomach and duodenal ulcers and increased NO- and MDA-levels in these tissues. As a NO-system effect, BPC 157 therapy (10 µg/kg, 10 ng/kg, intraperitoneally once a day or in drinking water, till the sacrifice) attenuated the increased NO- and MDA-levels and nullified, in rats, severe cyclophosphamide-ulcers and even stronger stomach and duodenal lesions after cyclophosphamide + L-NAME (5 mg/kg intraperitoneally once a day)...
March 2, 2017: Inflammopharmacology
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