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JOURNAL ARTICLE
Alaa H Sayed, Nadia S Mahmoud, Ola A M Mohawed, Hanaa H Ahmed
Gastric ulcer (GU) is one of the most common diseases of the upper gastrointestinal tract that affects millions of people worldwide. This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and adipose tissue-derived mesenchymal stem cells (ADSCs) in comparison with each treatment alone on the healing process of the experimentally induced GU in rats, and to uncover the involved pathways. Rats were divided into five groups: (1) Control, (2) GU, (3) PANTO, (4) ADSCs and (5) ADSCs + PANTO...
April 23, 2024: Inflammopharmacology
#2
JOURNAL ARTICLE
Dermoscopic Features of Subcorneal Hematoma on the Palms and Soles: Differences from Acral Melanoma.
Sang-Hyeon Won, Kyung-Nam Bae, Kihyuk Shin, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: The diagnosis of subcorneal hematoma (SH) can be challenging because the clinical presentation of SH can resemble melanocytic lesions. Few studies have examined the characteristic dermoscopic features of SH, but a more detailed large-scale study is needed to overcome the diagnostic challenge of differentiating it from acral melanoma. OBJECTIVES: To describe the dermoscopic features of SH. METHODS: We evaluated the clinical and dermoscopic features of 50 SH lesions from 43 patients at the Pusan National University Hospitals (Busan and Yangsan)...
December 2023: Acta Dermatovenerologica Croatica: ADC
#3
JOURNAL ARTICLE
Vishal Garimella, Nimay Anand, Elliott H Campbell, Christian L Baum, Afsaneh Alavi
When angiosarcoma, a rare and aggressive tumor of the soft tissue, develops in the setting of chronic lymphedema, it is referred to as Stewart-Treves syndrome. It is usually seen in chronic lymphedema of the upper limbs postmastectomy. Angiosarcoma developing in the lower limb in the setting of chronic lymphedema is rare and has a poor outcome. The presentation of angiosarcoma can vary, ranging from a bleeding papule to a plaque or a subcutaneous mass, which can later progress to ulceration or necrosis. Treatment for Stewart-Treves syndrome is aggressive because of its poor prognosis and usually requires a multidisciplinary approach of surgery, radiation, and chemotherapy...
May 1, 2024: Advances in Skin & Wound Care
#4
Kayla A Aikins, Zoé N Anderson, Benjamin L Bosse, Susan Knowles
A 26-year-old male with Behçet's disease (BD) presented with recurrent oral and genital ulcers, bilateral pneumonia, and a left lower pulmonary artery aneurysm. Endovascular coil embolization was initially performed, followed by treatment with prednisone, colchicine, and azathioprine. Despite treatment, disease progression occurred, requiring additional embolization, intravenous pulse methylprednisolone, and cyclophosphamide. Ultimately, a combination of medical and endovascular interventions resolved the pulmonary arterial aneurysms...
June 2024: Radiology Case Reports
#5
JOURNAL ARTICLE
Jun Yan He, Yang-Joon Kim, Elvira Mennillo, Iulia Rusu, Jared Bain, Arjun A Rao, Christopher Andersen, Karen Law, Hai Yang, Jessica Tsui, Alan Shen, Brittany Davidson, Divyashree Kushnoor, Yimin Shi, Frances Fan, Alexander Cheung, Li Zhang, Lawrence Fong, Alexis J Combes, Angela O Pisco, Michael G Kattah, David Y Oh
BACKGROUND: Colitis caused by checkpoint inhibitors (CPI) is frequent and is treated with empiric steroids, but CPI colitis mechanisms in steroid-experienced or refractory disease are unclear. METHODS: Using colon biopsies and blood from predominantly steroid-experienced CPI colitis patients, we performed multiplexed single-cell transcriptomics and proteomics to nominate contributing populations. RESULTS: CPI colitis biopsies showed enrichment of CD4+ resident memory (RM) T cells in addition to CD8+ RM and cytotoxic CD8+ T cells...
April 19, 2024: Journal for Immunotherapy of Cancer
#6
JOURNAL ARTICLE
Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S Czepielewski, Bram Verstockt, Alexandra E Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang, Zainab Al-Taie, Jerome Martin, Thomas Laurent, Huaibin M Ko, Minami Tokuyama, Michael Tankelevich, Hadar Meringer, Francesca Cossarini, Divya Jha, Azra Krek, John D Paulsen, Matthew D Taylor, Mohammad Zuber Nakadar, Joshua Wong, Emma C Erlich, Rachel L Mintz, Emily J Onufer, Beth A Helmink, Keshav Sharma, Adam Rosenstein, Danielle Ganjian, Grace Chung, Travis Dawson, Julius Juarez, Vijay Yajnik, Andrea Cerutti, Jeremiah J Faith, Mayte Suarez-Farinas, Carmen Argmann, Francesca Petralia, Gwendalyn J Randolph, Alexandros D Polydorides, Andrea Reboldi, Jean-Frederic Colombel, Saurabh Mehandru
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7+ ) plasmablasts in circulation of VDZ-treated patients suggested that VDZ targets gut-associated lymphoid tissue (GALT). Anti-α4β7 blockade in wild-type and photoconvertible (KikGR) mice confirmed a loss of GALT size and cellularity because of impaired cellular entry...
April 19, 2024: Science Immunology
#7
REVIEW
Willard N Applefeld, Jacob C Jentzer
The acute aortic syndromes (AAS) are life-threatening vascular compromises within the aortic wall. These include aortic dissection (AD), intramural hematoma (IMH), penetrating aortic ulcer (PAU), and blunt traumatic thoracic aortic injury (BTTAI). While patients classically present with chest pain, the presentation may be highly variable. Timely diagnosis is critical to initiate definitive treatment and maximize chances of survival. In high-risk patients, treatment should begin immediately, even while diagnostic evaluation proceeds...
May 2024: Cardiology Clinics
#8
JOURNAL ARTICLE
Valentyna Kostiuk, Michael Gazes, Soraya Fereydooni, Cassius Iyad Ochoa Chaar, Raul J Guzman, Britt Hansen Tonnessen
INTRODUCTION: Partial calcanectomy (PC) can be performed to treat chronic heel ulcers in patients with calcaneal osteomyelitis. Patients undergoing PC often have multiple comorbidities, limited mobility, and face high risk of major limb amputation. This study examined the extent of vascular diagnostic testing and interventions as well as long-term outcomes in patients undergoing PC. METHODS: A retrospective analysis was performed on patients who underwent PC for non-healing calcaneal ulcer over a ten-year period...
April 17, 2024: Vascular
#9
JOURNAL ARTICLE
Rong Yong, Ruoyu Mu, Congwei Han, Tzuwei Chao, Yu Liu, Lei Dong, Chunming Wang
The treatment of non-healing wounds, such as diabetic ulcers, remains a critical clinical challenge. Recent breakthroughs in cell therapy have shown great promise, with one primary focus on preparing cells with comprehensive reparative functions and foreseeable safety. In our previous study, we recapitulated the pro-regenerative and immunosuppressive functions of tumor-associated macrophages (TAMs) in non-tumor-derived macrophages, endowing the latter with characteristics for promoting diabetic wound healing - termed TAMs-educated macrophages (TAMEMs)...
April 17, 2024: Journal of Leukocyte Biology
#10
Yuta Yamada, Takao Ohki, Naoki Toya, Eisaku Ito, Hikaru Nakagawa
Thoracic endovascular aortic repair (TEVAR) of acute uncomplicated type B aortic dissection (uTBAD) has been discussed for its potential to prevent future aortic events. We present a fenestrated TEVAR in the case of an 86-year-old man with acute uTBAD with an isolated left vertebral artery (ILVA). The ILVA originated from the distal side of the left subclavian artery, the left subclavian artery, and the intramural hematoma with an ulcer-like projection extended close to the left subclavian artery. We selected a fenestrated stent graft to achieve a proximal healthy landing...
March 25, 2024: Annals of Vascular Diseases
#11
JOURNAL ARTICLE
Takuya Takahashi, Takehiro Takahashi, Tetsuya Ikawa, Hitoshi Terui, Toshiya Takahashi, Yuichiro Segawa, Hayakazu Sumida, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano
Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients...
April 15, 2024: Journal of Dermatology
#12
JOURNAL ARTICLE
Shaoling Yang, Liye Hu, Yue Zhao, Guangzhe Meng, Sijia Xu, Rui Han
Multidrug-resistant (MDR) bacterial infections have become increasingly common in recent years due to the increased prevalence of diabetic foot ulcers (DFUs). We carried out a meta-analysis aimed at investigating the prevalence of MDR bacteria isolated from DFUs and analysing the risk factors for MDR bacterial infection in patients with DFUs. The PubMed/Medline, Web of Science, Embase, Cochrane Library, Ovid, Scopus, and ProQuest databases were searched for studies published up to November 2023 on the clinical outcomes of MDR bacteria in DFUs...
April 2024: International Wound Journal
#13
JOURNAL ARTICLE
Clara Moriano Morales, Jenaro Graña Gil, Noé Brito García, José Luis Martín Varillas, Vanesa Calvo Del Río, Patricia Moya Alvarado, Francisco Javier Narváez García, Gerard Espinosa, Petra Díaz Del Campo Fontecha, Mercedes Guerra Rodríguez, José Mateo Arranz, Manuela López Gómez, Félix Manuel Francisco Hernández, M Mar Trujillo, Raquel Dos Santos Sobrín, Juan Ignacio Martín Sánchez, Jesús Maese Manzano, Julio Suárez Cuba
OBJECTIVE: To develop multidisciplinary recommendations based on available evidence and expert consensus for the therapeutic management of patients with refractory Behçet's syndrome (BS) (difficult to treat, severe resistant, severe relapse) to conventional treatment. METHODS: A group of experts identified clinical research questions relevant to the objective of the document. These questions were reformulated in PICO format (patient, intervention, comparison and outcome)...
April 12, 2024: Reumatología clinica
#14
JOURNAL ARTICLE
Sebouh Bazikian, Alyssa J Pyun, Hanke Zheng, William Padula, Tanzim Khan, Kenneth Ziegler, Laura Shin, Gregory A Magee, Vincent L Rowe, David G Armstrong
BACKGROUND: This study examined the efficacy of an interdisciplinary limb preservation service (LPS) in improving surgical outcomes for diabetic foot ulcer (DFU) patients compared to traditional care. METHODS: Data from January 1, 2017 to September 30, 2020 were retrospectively reviewed. An interdisciplinary LPS clinic began on August 1, 2018, coexisting with a preexisting single specialty service. Primary outcomes were major/minor amputation rates and ratios and hospital length of stay...
June 2024: Journal of Foot and Ankle Research
#15
JOURNAL ARTICLE
Vincenzo De Giorgi, Flavia Silvestri, Giovanni Cecchi, Federico Venturi, Biancamaria Zuccaro, Gabriella Perillo, Federica Cosso, Vincenza Maio, Sara Simi, Pietro Antonini, Serena Pillozzi, Lorenzo Antonuzzo, Daniela Massi, Laura Doni
Despite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospective case-control study was performed to identify clinical-dermoscopic and histopathological variables linked to local and distant metastases in melanomas ≤0.8 mm. Data from 1 January 2000 to 22 June 2022 were analyzed from two Italian skin cancer referral centers. Sixteen patients with ≤0.8 mm melanomas developing metastases were studied compared to controls without metastases over 5 years...
April 1, 2024: Cancers
#16
REVIEW
Gerhard Rümenapf, Nour Abilmona, Stephan Morbach, Martin Sigl
Background : In vascular medicine, peripheral arterial disease (PAD) and diabetic foot syndrome (DFS) are often considered synonymous with respect to the need for revascularization. In PAD patients, clinical symptoms reflect the degree of atherosclerotic disease, since peripheral innervation, including pain sensation, is not usually compromised. In DFS patients, however, symptoms of relevant foot ischemia are often absent and progression of ischemia goes unnoticed owing to diabetic polyneuropathy, the loss of nociception being the main trigger for foot ulcers...
April 8, 2024: Journal of Clinical Medicine
#17
JOURNAL ARTICLE
Khaled Atalla, M Elkady, Mostafa S Khalil, Osman Mahmoud, Mohammed Shahat
INTRODUCTION: Venous ulcers are a late and severe form of CVI and account for 70% of all etiologies that cause leg ulcers in the lower limb and they account for 20% of the 2.5 million cases complaining of chronic venous disease. Our study aims to investigate the effect of venous stenting of the deep veins on the healing of the venous ulcer. METHODS: This is a single-center, retrospective study conducted on prospectively recorded medical records of 78 patients with chronic deep venous diseases - C6 (either non-occlusive iliac venous lesion or post-thrombotic syndrome)...
April 8, 2024: Annals of Vascular Surgery
#18
Li Zhui, Jiang Chuli, Feng Yangyang, Zhao Yu, Ren Wei
Recurrence of a lung tumor invading the subclavian artery, causing stenosis and leading to finger ulcers as the initial symptom, is rare. We employed endovascular techniques, inserting a Viabahn® VBX covered stent (W. L. Gore & Associates, Flagstaff, Arizona) to aid in ulcer healing and improve the patient's quality of life. The patient, a 73-year-old male, had a history of lung adenocarcinoma resection two years prior but had not undergone follow-up examinations or cancer-specific treatments...
March 2024: Curēus
#19
JOURNAL ARTICLE
Nihal Şahin, Yunus E Bayrak, Hafize E Sönmez, Betül Sözeri
Background and Aim Chronic diseases profoundly impact people's quality of life (QoL). Behçet's Disease (BD) is a multisystemic chronic disease characterized by vasculitis of various vessels. We aimed to assess QoL in pediatric BD patients and their parents. Methods We included pediatric BD patients meeting the pediatric BD classification criteria in a cross-sectional study conducted from June to December 2022. We recorded patients' clinical characteristics and assessed their QoL using PedsQL. Parents' QoL was evaluated using WHOQOL-Bref...
April 1, 2024: Modern Rheumatology
#20
JOURNAL ARTICLE
Enrico De Lorenzis, Adi Mor, Rebecca L Ross, Stefano Di Donato, Revital Aricha, Ilan Vaknin, Francesco Del Galdo
BACKGROUND: Systemic sclerosis (SSc) is a heterogeneous disease, characterized by variable tissue and vascular fibrosis in the context of autoimmune activation. The C-C Motif Chemokine Ligand 24 (CCL24 or Eotaxin2) has been shown to promote microangiopathic, pro-inflammatory, and pro-fibrotic processes in preclinical models of SSc. Here we study serum CCL24 levels in a real-life cohort of SSc patients, to determine its distribution across disease features and its value in predicting disease progression and related mortality...
April 8, 2024: Arthritis Care & Research
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