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Jennifer E Baker, Michael D Goodman, Amy T Makley, Sabre M Stevens-Topie, Rosalie A Veile, Eric J Mahoney, Judy R Heyl, Daniel B Cox, Timothy A Pritts, Krishna P Athota
Introduction: Acute hemorrhage remains the leading cause of death in potentially survivable injuries. The use of topical hemostatic agents has increased over the last two decades with the evolution of damage control surgery. By 2008, the military widely adopted Combat Gauze as the hemostatic dressing of choice for compressible hemorrhage. The goal of this study was to compare the performance of a novel fibrin sealant patch to Combat Gauze in two clinically relevant models of hemorrhage...
July 11, 2018: Military Medicine
Nick Esmonde, Aaron Heston, Elie Ramly, Breanna Jedrezsweski, Alvin Annen, Jess Guerriero, Juliana Hansen, Jens Berli
Background: The majority of transgender research focuses on patients who fall within the gender binary of either trans-male or trans-female. This largely omits understanding of the "non-binary" gender identity, as it pertains to surgical care. Objective: To describe a single-institution experience performing chest affirming procedures in non-binary patients, including patient characteristics, surgical techniques, practice pearls, and outcomes. Methods: This is an observational study of non-binary patients undergoing a "chest affirming surgery" from 2012 to 2017...
July 10, 2018: Aesthetic Surgery Journal
Mostefa Moubri, Christophe Burucoa, Nicolas Kalach, R Rezki Larras, Nouria Nouar, Fawsia Mouffok, Zakia Arrada
We aimed to evaluate in an Algerian pediatric population the diagnostic performances of the IDEIA HpStAR noninvasive stool antigen test (Oxoid, Cambridge, UK) to detect Helicobacter pylori infection before and after eradication therapy. A prospective study including 158 symptomatic Algerian children was conducted. Patients were initially diagnosed with invasive (culture, histology, and rapid urease test) and noninvasive tests (urea breath test and IDEIA HpStAR test). Infected patients were treated, and 101 were controlled after treatment with two invasive (culture and histology) and two noninvasive tests (urea breath test and IDEIA HpStAR test)...
July 10, 2018: Journal of Tropical Pediatrics
H R Shin, H S Bae, B S Kim, H I Yoon, Y D Cho, W J Kim, K Y Choi, Y S Lee, K M Woo, J H Baek, H M Ryoo
Gain-of-function mutations in fibroblast growth factor receptors (FGFRs) cause congenital skeletal anomalies including craniosynostosis (CS), which is characterized by the premature closure of craniofacial sutures. Apert syndrome (AS) is one of the severest forms of CS, and the only treatment is surgical expansion of prematurely fused sutures in infants. Previously, we demonstrated that the prolyl isomerase PIN1 plays a critical role in mediating FGFR signaling, and that Pin1+/- mice exhibit delayed closure of cranial sutures...
July 11, 2018: Human Molecular Genetics
Yassir A Yassir, Ahmed M El-Angbawi, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare the quality of orthodontic treatment between 0.018-inch and 0.022-inch slot bracket systems. Subjects and methods: Eligible participants aged 12 years or over were allocated to the 0.018-inch or 0.022-inch slot MBT appliance (3M-Unitek, Monrovia, California, USA) using block randomization in groups of 10. Outcome measures included: 1. ABO cast-radiograph evaluation (CR-EVAL), 2. peer assessment rating (PAR) scores, 3. incisor inclination, and 4...
July 11, 2018: European Journal of Orthodontics
Ahmed M El-Angbawi, Yassir A Yassir, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare orthodontically induced inflammatory root resorption (OIIRR) and patient perception of pain during orthodontic treatment between 0.018-inch and 0.022-inch slot bracket systems. Subjects and methods: Eligible participants aged 12 years or above were allocated to treatment with the 0.018-inch or 0.022-inch slot MBT appliance (3M Unitek, Monrovia, California, USA) using block randomization in groups of 10. OIIRR was assessed radiographically using standardized periapical radiographs before and after 9 months from the start of treatment...
July 11, 2018: European Journal of Orthodontics
Andrew Zikic, Holger Schünemann, Teodora Wi, Ornella Lincetto, Nathalie Broutet, Nancy Santesso
Background: With the continued high prevalence of chlamydia worldwide and high risk of transfer from mothers to their infant during delivery, a need for safe and effective therapies for infants who acquire a chlamydial infection remains. We conducted a systematic review and meta-analysis of antibiotic treatments, including oral erythromycin, azithromycin, and trimethoprim, for neonatal chlamydial conjunctivitis. Methods: We searched Medline, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) from their inception to July 14, 2017...
July 10, 2018: Journal of the Pediatric Infectious Diseases Society
Sanne A A de Laat, Anja C Huizink, Michel H Hof, Tanja G M Vrijkotte
Background: Socioeconomically disadvantaged children often have psychosocial problems. This study examined the mediating role of maternal depressive symptoms during pregnancy, infancy and early childhood in the association between maternal education, as indicator of socioeconomic status (SES), and child's psychosocial problems. Methods: Included were 3410 children from the Amsterdam Born Children and their Development (ABCD) study. To assess the child's psychosocial problems at age 5-6 years, mothers and teachers completed the Strengths and Difficulties Questionnaire (SDQ)...
July 10, 2018: European Journal of Public Health
Andrea Agostinelli, Davide Carino, Bruno Borrello, Carla Marcato, Annalisa Volpi, Tiziano Gherli, Francesco Nicolini
OBJECTIVES: Blunt thoracic aortic injury can be treated with thoracic endovascular aortic repair (TEVAR) with excellent short and mid-term outcomes. However, few data are available about the long-term results. Our goal was to report our single-centre, 20-year experience using TEVAR to treat blunt thoracic aortic injury. METHODS: We retrospectively reviewed our institutional database to identify all patients treated with TEVAR for traumatic lesions of the aortic isthmus...
July 10, 2018: Interactive Cardiovascular and Thoracic Surgery
Yassir A Yassir, Ahmed M El-Angbawi, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare treatment duration between 0.018-inch and 0.022-inch slot systems and determine factors influencing treatment duration. Subjects and methods: Eligible participants aged 12 years or over were allocated to the 0.018-inch or 0.022-inch slot MBT appliance (3M-Unitek, Monrovia, California, USA) using block randomization in groups of 10. Outcome measures included duration of: 1. overall treatment, 2. levelling and alignment, 3. working and finishing, and 4...
July 11, 2018: European Journal of Orthodontics
Pantelis A Sarafidis, Francesca Mallamaci, Charalampos Loutradis, Robert Ekart, Claudia Torino, Antonios Karpetas, Vasileios Raptis, Athanasios Bikos, Aikaterini Papagianni, Olga Balafa, Konstantinos Siamopoulos, Giovanni Pisani, Massimo Morosetti, Antonio Del Giudice, Fillipo Aucella, Luca Di Lullo, Rocco Tripepi, Giovanni Tripepi, Kitty Jager, Friedo Dekker, Gerard London, Carmine Zoccali
Background: Population-specific consensus documents recommend that the diagnosis of hypertension in haemodialysis patients be based on 48-h ambulatory blood pressure (ABP) monitoring. However, until now there is just one study in the USA on the prevalence of hypertension in haemodialysis patients by 44-h recordings. Since there is a knowledge gap on the problem in European countries, we reassessed the problem in the European Cardiovascular and Renal Medicine working group Registry of the European Renal Association-European Dialysis and Transplant Association...
July 10, 2018: Nephrology, Dialysis, Transplantation
R Levine, G Horst, R Tonda, B Lumpkins, G Mathis
This study determined the effect of a dried algae product containing beta-1,3-glucan on broiler performance and immunity during an Eimeria challenge. Heterotrophically grown Euglena gracilis, which contained ∼55% beta-1,3-glucan, was dried and milled for inclusion into a non-medicated starter diet. Two experiments were conducted to evaluate dietary treatments containing 0, 50, 100, 150, and 200 g/ton dried algae. In both experiments, male broilers were orally challenged on day 14 with a coccidial inoculum consisting of E...
July 11, 2018: Poultry Science
Han-Yu Deng, Gang Li, Jun Luo, Guha Alai
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was: Can definitive chemoradiotherapy (CRT) be an alternative to surgery for early-stage oesophageal cancer? A total of 622 papers were found using the reported search, of which 5 cohort studies represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
July 10, 2018: Interactive Cardiovascular and Thoracic Surgery
Christie Jackson, Brandon J Weiss, Marylene Cloitre
Introduction: Group Skills Training in Affective and Interpersonal Regulation (STAIR) is an evidence-based, manualized treatment for individuals with post-traumatic stress symptoms, that focuses on improving functioning through mood management (e.g., emotion regulation) and relationship skills development. To date, no study has evaluated the potential benefit of group STAIR among Veterans. Feasibility of delivering STAIR in a mixed-gender group format and the potential impact of gender on outcome were examined...
July 11, 2018: Military Medicine
Teresa M Seccia, Brasilina Caroccia, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez, Gian Paolo Rossi
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APA) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoantibodies activating the angiotensin II type 1 receptor, have rapidly advanced the understanding of the biology of primary aldosteronism (PA), in particular that of APA. Hence, the main purpose of this review is to discuss how discoveries of the last decade could impact on histopathology analysis and clinical practice...
July 10, 2018: Endocrine Reviews
Meital Zur, Racheli Magnezi, Shirley Portuguese, Inbal Reuveni, Ron Kedem, Eyal Fruchter
Introduction: Attention deficit hyperactive disorder (ADHD) is prevalent in 5.9-7.1% of children and adolescents, and 5% of adults. It results in poor academic, occupational, and social functioning. Pharmacotherapy improves core symptoms; however, average adherence levels are low and decrease at 16-17 years of age, just before the recruitment age to Israel Defense Forces (IDF). This study evaluated the effect of adherence to ADHD pharmacotherapy on occupational performance among soldiers...
July 11, 2018: Military Medicine
Juan Ignacio Arraras, Ana Manterola, Jose Juan Illarramendi, Gemma Asin, Susana de la Cruz, Berta Ibañez, Arkaitz Galbete, Esteban Salgado, Uxue Zarandona, Ruth Vera, Miguel Angel Dominguez, Enrique Martinez
PURPOSE: This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups. METHODS: Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
Marco Possanzini, Carlo Greco
The treatment of metastatic breast cancer is largely focused on systemic therapy. However, over the past decades, there has been growing interest in the use of metastasis-directed therapy in selected cases presenting with an oligometastatic phenotype, i.e. low disease burden with a more indolent biology. Identification of the oligometastatic breast cancer population has, so far, proven elusive. Stereotactic radiotherapy offers an effective, non-invasive approach to ablate metastatic disease both in the brain and in extra-cranial settings...
June 28, 2018: Breast: Official Journal of the European Society of Mastology
Matteo Lambertini, Valeria Fontana, Claudia Massarotti, Francesca Poggio, Chiara Dellepiane, Giuseppina Iacono, Annalisa Abate, Loredana Miglietta, Chiara Ferreccio, Maria Carolina Pescio, Benedetta Conte, Eva Blondeaux, Claudia Bighin, Alessia D'Alonzo, Marina Vaglica, Elisa Zanardi, Francesco Boccardo, Alberto Ballestrero, Paola Anserini, Lucia Del Mastro
BACKGROUND: Despite the availability of different strategies for ovarian function and/or fertility preservation in young breast cancer patients candidates for chemotherapy, limited data are available on patients' actual need of these options. PATIENTS AND METHODS: The PREFER study is a prospective cohort study including premenopausal women with newly diagnosed early stage breast cancer between the age of 18 and 45 years and candidates for chemotherapy. The study aimed to investigate patients' preferences and their choices of the different available strategies for ovarian function and/or fertility preservation (i...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
F Salamanna, V Borsari, D Contartese, N Nicoli Aldini, M Fini
Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP)...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
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