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https://www.readbyqxmd.com/read/27560839/polymorphisms-fto-rs9939609-pparg-rs1801282-and-adipoq-rs4632532-and-rs182052-but-not-lifestyle-are-associated-with-obesity-related-traits-in-mexican-children
#1
C Muñoz-Yáñez, R Pérez-Morales, H Moreno-Macías, E Calleros-Rincón, G Ballesteros, R A González, J Espinosa
Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded...
July 14, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27419399/polymorphisms-fto-rs9939609-pparg-rs1801282-and-adipoq-rs4632532-and-rs182052-but-not-lifestyle-are-associated-with-obesity-related-traits-in-mexican-children
#2
C Muñoz-Yáñez, R Pérez-Morales, H Moreno-Macías, E Calleros-Rincón, G Ballesteros, R A González, J Espinosa
Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded...
July 14, 2016: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/27240401/complementary-effects-of-genetic-variations-in-lepr-on-body-composition-and-soluble-leptin-receptor-concentration-after-3-month-lifestyle-intervention-in-prepubertal-obese-children
#3
Joanna Gajewska, Alina Kuryłowicz, Ewa Mierzejewska, Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Halina Weker, Monika Puzianowska-Kuźnicka
In obese individuals, weight loss might be affected by variants of the adipokine-encoding genes. We verified whether selected functional single nucleotide polymorphisms in LEP, LEPR and ADIPOQ are associated with changes in serum levels of the respective adipokines and weight loss in 100 prepubertal obese (SDS-BMI > 2) Caucasian children undergoing lifestyle intervention. Frequencies of the -2548G > A LEP, Q223R LEPR, K656N LEPR, -11377C > G and -11426A > G ADIPOQ polymorphisms were analyzed by restriction fragment length polymorphism...
2016: Nutrients
https://www.readbyqxmd.com/read/26370001/obesity-linked-diabetes-in-the-arab-world-a-review
#4
REVIEW
B Abuyassin, I Laher
The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. Replication studies identify several genetic variants in Arabs with obesitylinked diabetes...
June 2015: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/26192702/adipoq-11377c-g-polymorphism-increases-the-risk-of-adipokine-abnormalities-and-child-obesity-regardless-of-dietary-intake
#5
Joanna Gajewska, Alina Kuryłowicz, Jadwiga Ambroszkiewicz, Ewa Mierzejewska, Magdalena Chełchowska, Katarzyna Szamotulska, Halina Weker, Monika Puzianowska-Kuźnicka
OBJECTIVE: The aim of the present study was to verify whether selected functional single nucleotide polymorphisms in LEP, LEPR, and ADIPOQ loci are associated with the development of obesity and serum levels of the respective adipokines in prepubertal white children with obesity. METHODS: Frequencies of -2548G>A LEP (rs7799039), Q223R (rs1137101) and K656N (rs8129183) LEPR, and -11377C>G (rs266729) and -11426A>G (rs16861194) ADIPOQ polymorphisms were analyzed by restriction fragment length polymorphism in 101 obese (standard deviation score [SDS]-body mass index [BMI] >2) and 67 normal-weight (SDS-BMI <- 1 + 1 >) children...
January 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25127329/studying-progression-from-glucose-intolerance-to-type-2-diabetes-in-obese-children
#6
REVIEW
Irina A Dubinina, Dimitry A Chistiakov, Irina A Eremina, Alexei N Brovkin, Lyubov I Zilberman, Alexei G Nikitin, Tamara L Kuraeva, Valery V Nosikov, Valentina A Peterkova, Ivan I Dedov
AIM: Identification of metabolic and genetic factors capable to mediate progression from normal glucose tolerance (NGT) through impaired glucose tolerance (IGT) to type 2 diabetes (T2D) in childhood obesity. PATIENTS AND METHODS: Three groups of obese children with NGT (n=54), IGT (n=35), and T2D (n=62) were evaluated. A control group of non-obese normal children (n=210) was also studied. In obese patients, an oral glucose tolerance test (OGTT) was performed. Insulin resistance (IR) was assessed using HOMA-IR index...
July 2014: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/24549138/dna-methylation-of-leptin-and-adiponectin-promoters-in-children-is-reduced-by-the-combined-presence-of-obesity-and-insulin-resistance
#7
M C García-Cardona, F Huang, J M García-Vivas, C López-Camarillo, B E Del Río Navarro, E Navarro Olivos, E Hong-Chong, F Bolaños-Jiménez, L A Marchat
OBJECTIVE: Epigenetic alterations have been suggested to be associated with obesity and related metabolic disorders. Here we examined the correlation between obesity and insulin resistance with the methylation frequency of the leptin (LEP) and adiponectin (ADIPOQ) promoters in obese adolescents with the aim to identify epigenetic markers that might be used as tools to predict and follow up the physiological alterations associated with the development of the metabolic syndrome. SUBJECTS: One hundred and six adolescents were recruited and classified according to body mass index and homeostasis model of assessment-insulin resistance index...
November 2014: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/23950976/contribution-of-common-genetic-variants-to-obesity-and-obesity-related-traits-in-mexican-children-and-adults
#8
Paola León-Mimila, Hugo Villamil-Ramírez, Marisela Villalobos-Comparán, Teresa Villarreal-Molina, Sandra Romero-Hidalgo, Blanca López-Contreras, Roxana Gutiérrez-Vidal, Joel Vega-Badillo, Leonor Jacobo-Albavera, Carlos Posadas-Romeros, Adrián Canizalez-Román, Blanca Del Río-Navarro, Francisco Campos-Pérez, Victor Acuña-Alonzo, Carlos Aguilar-Salinas, Samuel Canizales-Quinteros
BACKGROUND: Several studies have identified multiple obesity-associated loci mainly in European populations. However, their contribution to obesity in other ethnicities such as Mexicans is largely unknown. The aim of this study was to examine 26 obesity-associated single-nucleotide polymorphisms (SNP) in a sample of Mexican mestizos. METHODS: 9 SNPs in biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) were genotyped in 1,156 unrelated Mexican-Mestizos including 683 cases (441 obese class I/II and 242 obese class III) and 473 normal-weight controls...
2013: PloS One
https://www.readbyqxmd.com/read/23806739/interactions-between-adipoq-gene-variants-and-dietary-monounsaturated-saturated-fatty-acid-ratio-on-serum-lipid-levels-in-korean-children
#9
J Y Park, H-J Lee, H B Jang, J-Y Hwang, J H Kang, B-G Han, J-Y Lee, J Song
BACKGROUND AND AIMS: Adiponectin plays important roles in the regulation of insulin action and metabolism of glucose and lipids. We investigated whether ADIPOQ genetic variants are associated with serum lipid levels in Korean children and whether those influences might be modulated by dietary factors such as dietary monounsaturated fatty acid to saturated fatty acid ratio (MUFA:SFA). METHOD AND RESULTS: The study included a population-based sample of 687 children aged 7-11 years in Gwacheon city, Kyunggi Province, Korea...
January 2014: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/22471989/adiponectin-an-adipocyte-derived-hormone-and-its-gene-encoding-in-children-with-chronic-kidney-disease
#10
Manal F Elshamaa, Samar M Sabry, Marwa M El-Sonbaty, Eman A Elghoroury, Nahed Emara, Mona Raafat, Dina Kandil, Gamila Elsaaid
BACKGROUND: The prevalence of cardiovascular disease (CVD) and inflammation is high in patients with chronic kidney disease (CKD). Adiponectin (ADPN) is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk for CVD. METHODS: On seventy eight advanced CKD (stages 4 and 5) pediatric patients undergoing maintenance hemodialysis( MHD) or conservative treatment (CT) the following parameters were studied: body mass index, left ventricular mass index(LVMI), serum adiponectin , cholesterol, HDL-cholesterol, high sensitivity C-reactive protein (hs CRP),interleukin 6(IL6) and single-nucleotide polymorphisms (SNPs) in the ADIPOQ gene at positions 45, and 276...
2012: BMC Research Notes
https://www.readbyqxmd.com/read/21938426/influence-of-the-interaction-between-the-adiponectin-g276t-polymorphism-and-body-mass-index-on-lipid-levels-in-healthy-children
#11
Pía Riestra, Alicia García-Anguita, Miguel A Lasunción, Alipio Mangas, Manuel de Oya, Carmen Garcés
Adiponectin is an adipose tissue-specific hormone which is inversely associated with metabolic alterations related to atherosclerosis. Polymorphisms in the adiponectin gene (AdipoQ) have been related to low adiponectin levels as well as several cardiovascular risk factors, but this association remains controversial. In our study we investigated the relationship between the AdipoQ T45G (rs: 2241766) and G276T (rs: 1501299) polymorphisms and adiponectin concentrations, blood pressure, and lipid and insulin levels, in a population-based sample of 12- to 16-year-old children...
April 2012: Molecular Biology Reports
https://www.readbyqxmd.com/read/21755292/effect-of-three-common-snps-in-5-flanking-region-of-lep-and-adipoq-genes-on-their-expression-in-polish-obese-children-and-adolescents
#12
J Cieslak, M Bartz, M Stachowiak, B Skowronska, K A Majewska, J Harasymczuk, W Stankiewicz, P Fichna, M Switonski
Genes encoding adipokines are considered as candidates for human obesity. In this study we analyzed the expression of leptin (LEP) and adiponectin (ADIPOQ) genes in relation to common 5'-flanking or 5'UTR variants: -2548G>A (LEP), 19A>G (LEP) and -11377C>G (ADIPOQ) in Polish obese children and adolescents. Relative transcription levels in the subcutaneous adipose tissue (real time RT-PCR) and serum protein concentrations (RIA) were measured in 48 obese subjects with known genotypes at three polymorphic sites and in five non-obese controls...
April 2012: Molecular Biology Reports
https://www.readbyqxmd.com/read/20842437/polymorphisms-in-5-flanking-regions-of-genes-encoding-adiponectin-leptin-and-resistin-are-not-associated-with-obesity-of-polish-children-and-adolescents
#13
Jakub Cieslak, Anna Skorczyk, Monika Stachowiak, Maciej Szydlowski, Maria Grzes, Paulina Paczynska, Bogda Skowronska, Katarzyna Majewska, Witold Stankiewicz, Piotr Fichna, Marek Switonski
Genes encoding adipokines are important functional candidates for development of obesity. In this study we screened for polymorphism 5'-flanking regions of the adiponectin (ADIPOQ), leptin (LEP) and resistin (RETN) genes in a cohort of Polish obese children and adolescents (n = 243) and a control group of non-obese adults (n = 100). Altogether 13 SNPs (single nucleotide polymorphisms) and 1 InDel (insertion/deletion polymorphism) were found. Among them five polymorphisms, localized in the LEP gene, turned out to be novel, but their distribution was insufficient for association studies...
March 2011: Molecular Biology Reports
https://www.readbyqxmd.com/read/19893502/early-detrimental-metabolic-outcomes-of-rs17300539-a-allele-of-adipoq-gene-despite-higher-adiponectinemia
#14
Anita Morandi, Claudio Maffeis, Stéphane Lobbens, Nabila Bouatia-Naji, Barbara Heude, Leonardo Pinelli, David Meyre, Philippe Froguel
Minor allele A of single-nucleotide polymorphism (SNP) 11391 G/A of ADIPOQ gene (rs17300539) has been consistently associated with higher adiponectin levels in adults and children. The aim of this study was to investigate the metabolic role of this variant in a large cohort of children of European origin. A total of 1,852 children from two general populations in Verona and in Fleurbaix-Laventie and from the Lille childhood obesity cohort, were genotyped and pooled together after checking for the absence of genetic heterogeneity for rs17300539 between Italian and French children...
July 2010: Obesity
https://www.readbyqxmd.com/read/19543786/adipoq-gene-polymorphism-rs1501299-interacts-with-fibre-intake-to-affect-adiponectin-concentration-in-children-the-gene-diet-attica-investigation-on-childhood-obesity
#15
Ioanna Ntalla, George Dedoussis, Mary Yannakoulia, Melissa C Smart, Eirini Louizou, Sophia D Sakka, Constantina Papoutsakis, Philippa J Talmud
BACKGROUND: Adiponectin, an adipose-derived hormone with central and peripheral actions, is involved in the regulation of energy homeostasis. Interactions between genetic and environmental factors have been associated with decrease in circulating adiponectin leading to obesity. AIM: We investigated whether variants of the ADIPOQ gene encoding adiponectin interact with diet to predict serum adiponectin concentration. METHODS: A cross-sectional study of healthy school-aged children of Greek origin (n = 991), aged 11...
December 2009: European Journal of Nutrition
https://www.readbyqxmd.com/read/18848781/a-genetic-contribution-to-circulating-cytokines-and-obesity-in-children
#16
Guowen Cai, Shelley A Cole, Nancy F Butte, C Wayne Smith, Nitesh R Mehta, V Saroja Voruganti, J Michael Proffitt, Anthony G Comuzzie
Cytokines are considered to be involved in obesity-related metabolic diseases. Study objectives are to determine the heritability of circulating cytokine levels, to investigate pleiotropy between cytokines and obesity traits, and to present genome scan results for cytokines in 1030 Hispanic children enrolled in VIVA LA FAMILIA Study. Cytokine phenotypes included monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), transforming growth factor beta 1 (TGF-beta1), C-reactive protein (CRP), regulated upon activation, normal T-cell expressed and secreted (RANTES) and eotaxin...
November 2008: Cytokine
https://www.readbyqxmd.com/read/18645733/interaction-between-pparg-pro12ala-and-adipoq-g276t-concerning-cholesterol-levels-in-childhood-obesity
#17
Lovisa E Johansson, Pernilla Danielsson, Svante Norgren, Claude Marcus, Martin Ridderstråle
AIM: The aim of this study was to investigate the role of two candidate gene polymorphisms for insulin resistance and lipid levels in obese children and adolescents. METHODS: Two markers of insulin resistance and lipid levels, Pro12Ala in peroxisome proliferator-activated receptor-gamma2 (PPARG) and G276T in adiponectin (ADIPOQ), were genotyped in 285 obese children and adolescents. As the apolipoprotein E (APOE) polymorphisms C112R and R158C are known to have a profound impact on lipid levels in both children and adults, results were adjusted for APOE genotype...
2009: International Journal of Pediatric Obesity: IJPO
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