keyword
https://read.qxmd.com/read/36850008/shared-and-unique-effects-of-apoe%C3%AE%C2%B54-and-pathogenic-gene-mutation-on-cognition-and-imaging-in-preclinical-familial-alzheimer-s-disease
#21
JOURNAL ARTICLE
Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, Jianping Jia
BACKGROUND: Neuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer's disease (FAD). This study investigated the effects of APOEε4 and known pathogenic gene mutation on different cognitive domains and circuit imaging markers in preclinical FAD. METHODS: One hundred thirty-nine asymptomatic subjects in FAD families, including 26 APOEε4 carriers, 17 APP and 20 PS1 mutation carriers, and 76 control subjects, went through a series of neuropsychological tests and MRI scanning...
February 28, 2023: Alzheimer's Research & Therapy
https://read.qxmd.com/read/36604747/altered-metabolic-connectivity-within-the-limbic-cortico-striato-thalamo-cortical-circuit-in-presymptomatic-and-symptomatic-behavioral-variant-frontotemporal-dementia
#22
JOURNAL ARTICLE
Li Liu, Min Chu, Binbin Nie, Deming Jiang, Kexin Xie, Yue Cui, Lin Liu, Yu Kong, Zhongyun Chen, Haitian Nan, Pedro Rosa-Neto, Liyong Wu
BACKGROUND: Behavioral variant frontotemporal dementia (bvFTD) is predominantly considered a dysfunction in cortico-cortical transmission, with limited direct investigation of cortical-subcortical transmission. Thus, we aimed to characterize the metabolic connectivity between areas of the limbic cortico-striato-thalamic-cortical (CSTC) circuit in presymptomatic and symptomatic bvFTD patients. METHODS: Thirty-three bvFTD patients and 33 unrelated healthy controls were recruited for this study...
January 5, 2023: Alzheimer's Research & Therapy
https://read.qxmd.com/read/36343236/midbrain-dopamine-neurons-arbiter-ocd-like-behavior
#23
JOURNAL ARTICLE
Jinwen Xue, Dandan Qian, Bingqian Zhang, Jingxuan Yang, Wei Li, Yifei Bao, Shi Qiu, Yi Fu, Shaoli Wang, Ti-Fei Yuan, Wei Lu
The neurobiological understanding of obsessive-compulsive disorder (OCD) includes dysregulated frontostriatal circuitry and altered monoamine transmission. Repetitive stereotyped behavior (e.g., grooming), a featured symptom in OCD, has been proposed to be associated with perturbed dopamine (DA) signaling. However, the precise brain circuits participating in DA's control over this behavioral phenotype remain elusive. Here, we identified that DA neurons in substantia nigra pars compacta (SNc) orchestrate ventromedial striatum (VMS) microcircuits as well as lateral orbitofrontal cortex (lOFC) during self-grooming behavior...
November 16, 2022: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/36302082/food-addiction-a-comprehensive-review
#24
REVIEW
Ligia Florio, Dângela L S Lassi, Cintia de Azevedo-Marques Perico, Natalia G Vignoli, Julio Torales, Antonio Ventriglio, João M Castaldelli-Maia
Food addiction is associated with dysfunctions in the reward circuit, such as hyperresponsiveness during the exposure to high-calorie flavors in overweight and obese individuals. Similar to drug addiction, there is also impaired self-regulatory control supported by deregulation of the frontostriatal circuit. The inclusion of validated measures of food addiction in clinical research, such as the Yale Food Addiction Scale, has increased the understanding of the clinical utility of this concept. Furthermore, food addiction, eating disorders, and obesity are interrelated...
November 1, 2022: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/36127748/transdiagnostic-profiles-of-behaviour-and-communication-relate-to-academic-and-socioemotional-functioning-and-neural-white-matter-organisation
#25
JOURNAL ARTICLE
Silvana Mareva, Danyal Akarca, Joni Holmes
BACKGROUND: Behavioural and language difficulties co-occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental disorders and the heterogeneity within them. METHODS: We recruited a large transdiagnostic cohort of children with complex needs (N = 805) to identify distinct subgroups of children with common profiles of behavioural and language strengths and difficulties...
September 20, 2022: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://read.qxmd.com/read/36067733/frontostriatal-circuits-alterations-associated-with-cognitive-flexibility-deterioration-in-huntington-s-disease
#26
Gustavo Padron-Rivera, Angel Omar Romero-Molina, Rosalinda Diaz, Israel Vaca-Palomares, Adriana Ochoa-Morales, César Romero-Rebollar, Amanda Chirino-Pérez, Juan Fernandez-Ruiz
BACKGROUND: Recent resting-state functional magnetic resonance imaging studies have reported abnormal functional connectivity (FC) in the prefrontal cortex (PFC)-striatum circuit in patients with premanifest Huntington's disease (HD). However, there is a lack of evidence showing persistence of abnormal frontostriatal FC and its relation to cognitive flexibility performance in patients with clinically manifest HD. OBJECTIVE: To evaluate the resting state FC integrity of the frontostriatal circuit and its relation to cognitive flexibility in HD patients and Healthy Controls (HC)...
September 6, 2022: Neuro-degenerative Diseases
https://read.qxmd.com/read/36048377/pre-operative-cognitive-burden-as-predictor-of-motor-outcome-following-bilateral-subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease
#27
JOURNAL ARTICLE
Venus Tang, Xian Lun Zhu, Claire Lau, Anne Chan, Karen Ma, Jonas Yeung, Tom Cheung, Jill Abrigo, David Yuen Chung Chan, Danny Chan, Vincent Mok, Wai Sang Poon
INTRODUCTION: The interrelationship between neurocognitive impairments and motor functions was observed in patients with advanced Parkinson's disease (PD). This study was conducted to identify pre-operative neurocognitive and clinical predictors of short-term motor outcome following subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: All consecutive PD patients who were eligible for bilateral STN-DBS from 2009 to 2019 were evaluated before and at 1 year following surgery...
September 1, 2022: Neurological Sciences
https://read.qxmd.com/read/36002101/charting-the-neural-circuits-disruption-in-inhibitory-control-and-its-subcomponents-across-psychiatric-disorders-a-neuroimaging-meta-analysis
#28
JOURNAL ARTICLE
Haifeng Yan, Way K W Lau, Simon B Eickhoff, Jixin Long, Xiaoqi Song, Chanyu Wang, Jiubo Zhao, Xiangang Feng, Ruiwang Huang, Maosheng Wang, Xiaoyuan Zhang, Ruibin Zhang
BACKGROUND: Inhibitory control, comprising cognitive inhibition and response inhibition, showed consistent deficits among several major psychiatric disorders. We aim to identify the trans-diagnostic convergence of neuroimaging abnormalities underlying inhibitory control across psychiatric disorders. METHODS: Inhibitory control tasks neuroimaging, including functional magnetic resonance imaging, single-photon emission computed tomography, and positron emission tomography articles published in PubMed and Web of Science before April 2020 comparing healthy controls with patients with several psychiatric disorders were searched...
August 21, 2022: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/35836582/anhedonia-in-depression-and-schizophrenia-brain-reward-and-aversion-circuits
#29
REVIEW
Sugai Liang, Yue Wu, Li Hanxiaoran, Andrew J Greenshaw, Tao Li
Anhedonia, which is defined as markedly diminished interest or pleasure, is a prominent symptom of psychiatric disorders, most notably major depressive disorder (MDD) and schizophrenia. Anhedonia is considered a transdiagnostic symptom that is associated with deficits in neural reward and aversion functions. Here, we review the characteristics of anhedonia in depression and schizophrenia as well as shared or disorder-specific anhedonia-related alterations in reward and aversion pathways of the brain. In particular, we highlight that anhedonia is characterized by impairments in anticipatory pleasure and integration of reward-related information in MDD, whereas anhedonia in schizophrenia is associated with neurocognitive deficits in representing the value of rewards...
2022: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/35785575/potential-brain-recovery-of-frontostriatal-circuits-in-heroin-users-after-prolonged-abstinence-a-preliminary-study
#30
JOURNAL ARTICLE
Ling Lu, Wenhan Yang, Xiaozi Zhang, Fei Tang, Yanyao Du, Li Fan, Jing Luo, Cui Yan, Jun Zhang, Jun Li, Jixin Liu, Karen M von Deneen, Dahua Yu, Jun Liu, Kai Yuan
Neuroscientists have devoted efforts to explore potential brain recovery after prolonged abstinence in heroin users (HU). However, not much is known about whether frontostriatal circuits can recover after prolonged abstinence in HU. An eight-month longitudinal study was carried out for HU. Two MRI scans were obtained at baseline (HU1) and 8-month follow-up (HU2). The functional and structural connectivities of dorsal and ventral frontostriatal pathways were measured by resting-state functional connectivity (RSFC) and diffusion tensor imaging (DTI)...
August 2022: Journal of Psychiatric Research
https://read.qxmd.com/read/35569106/cognitive-impairment-in-idiopathic-normal-pressure-hydrocephalus
#31
REVIEW
Haoyun Xiao, Fan Hu, Jing Ding, Zheng Ye
Idiopathic normal pressure hydrocephalus (iNPH) is a significant cause of the severe cognitive decline in the elderly population. There is no cure for iNPH, but cognitive symptoms can be partially alleviated through cerebrospinal fluid (CSF) diversion. In the early stages of iNPH, cognitive deficits occur primarily in the executive functions and working memory supported by frontostriatal circuits. As the disease progresses, cognition declines continuously and globally, leading to poor quality of life and daily functioning...
May 15, 2022: Neuroscience Bulletin
https://read.qxmd.com/read/35389722/neuropsychological-neuropsychiatric-and-clinical-correlates-of-affective-and-cognitive-theory-of-mind-in-parkinson-s-disease-a-meta-analysis
#32
JOURNAL ARTICLE
Gianpaolo Maggi, Amable Manuel Cima Muñoz, Ignacio Obeso, Gabriella Santangelo
OBJECTIVE: Theory of mind (ToM) is the ability to infer others' mental (Cognitive) and emotional (Affective) states, both being impaired in Parkinson's disease (PD). However, the clinical, neuropsychological, and neuropsychiatric features underlying Affective and Cognitive ToM deficits in PD are unclear. Therefore, we performed a meta-analytic study to test whether PD demographical, clinical, neuropsychological, or neuropsychiatric changes related differently to both ToM processes. METHOD: A systematic literature search was performed up to January 2022, including a total of 31 studies following our search terms...
September 2022: Neuropsychology
https://read.qxmd.com/read/35108587/alterations-of-default-mode-and-cingulo-opercular-salience-network-and-frontostriatal-circuit-a-candidate-endophenotype-of-obsessive-compulsive-disorder
#33
JOURNAL ARTICLE
Hirofumi Tomiyama, Keitaro Murayama, Kiyotaka Nemoto, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Akira Matsuo, Aikana Ohno, Mingi Kang, Osamu Togao, Akio Hiwatashi, Kousei Ishigami, Tomohiro Nakao
Background It is gradually becoming clear that obsessive-compulsive disorder (OCD) patients have aberrant resting-state large-scale intrinsic networks of cingulo-opercular salience (SN), default mode (DMN), and front-parietal network (FPN). However, it remains unknown whether unaffected first-degree relatives of OCD patients have these alterations as a vulnerability marker to the disorder. Methods We performed resting-state functional magnetic resonance imaging (rsfMRI) scans of 47 medication-free OCD patients, 21 unaffected healthy first-degree relatives of OCD patients, and 62 healthy control (HC) participants...
June 8, 2022: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/35094052/frontostriatothalamic-effective-connectivity-and-dopaminergic-function-in-the-psychosis-continuum
#34
JOURNAL ARTICLE
Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Alvarez-Jimenez, Jessica Graham, Hok P Yuen, Susy Harrigan, Vanessa Cropley, Sujit Sharma, Bharat Saluja, Rob Williams, Christos Pantelis, Stephen J Wood, Brian O'Donoghue, Shona Francey, Patrick McGorry, Kevin Aquino, Alex Fornito
Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction is driven by aberrant bottom-up subcortical signalling or impaired top-down cortical regulation. We used spectral dynamic causal modelling of resting-state functional MRI to characterize the effective connectivity of dorsal and ventral FST circuits in a sample of 46 antipsychotic-naïve first-episode psychosis patients and 23 controls and an independent sample of 36 patients with established schizophrenia and 100 controls...
January 5, 2023: Brain
https://read.qxmd.com/read/35090884/mapping-frontostriatal-white-matter-tracts-and-their-association-with-reward-related-ventral-striatum-activation-in-adolescence
#35
JOURNAL ARTICLE
Julianna R Calabrese, Leigh G Goetschius, Laura Murray, Megan R Kaplan, Nestor Lopez-Duran, Colter Mitchell, Luke W Hyde, Christopher S Monk
The ventral striatum (VS) is implicated in reward processing and motivation. Human and non-human primate studies demonstrate that the VS and prefrontal cortex (PFC), which comprise the frontostriatal circuit, interact to influence motivated behavior. However, there is a lack of research that precisely maps and quantifies VS-PFC white matter tracts. Moreover, no studies have linked frontostriatal white matter to VS activation. Using a multimodal neuroimaging approach with diffusion MRI (dMRI) and functional MRI (fMRI), the present study had two objectives: 1) to chart white matter tracts between the VS and specific PFC structures and 2) assess the association between the degree of VS-PFC white matter tract connectivity and VS activation in 187 adolescents...
April 1, 2022: Brain Research
https://read.qxmd.com/read/35067481/cognitive-functions-in-late-life-depression
#36
JOURNAL ARTICLE
Caroline Masse, Gilles Chopard, Djamila Bennabi, Emmanuel Haffen, Pierre Vandel
Cognitive disorders are frequently found during late-life depression (LLD). Many cognitive functions may be concerned and can be explained by frontostriatal brain circuits and hippocampus dysfunctions partly through abnormalities related to cerebrovascular diseases. It seems important to distinguish between early and late onset depression, the cognitive characterisation and aetiopathogenesis of which differ in some respects. Cognitive impairment may represent markers of depression, but it is still unclear whether potential biomarkers of disease should be considered as markers of condition, trait or risk factors...
January 21, 2022: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://read.qxmd.com/read/35049521/comparison-of-frontostriatal-circuits-in-adolescent-nicotine-addiction-and-internet-gaming-disorder
#37
REVIEW
Karen M von Deneen, Hadi Hussain, Junaid Waheed, Wen Xinwen, Dahua Yu, Kai Yuan
BACKGROUND: Recently, there has been significantly increased participation in online gaming and other addictive behaviors particularly in adolescents. Tendencies to avoid social interaction and become more involved in technology-based activities pose the danger of creating unhealthy addictions. Thus, the presence of relatively immature cognitive control and high risk-taking properties makes adolescence a period of major changes leading to an increased rate of emotional disorders and addiction...
March 28, 2022: Journal of Behavioral Addictions
https://read.qxmd.com/read/34913220/similarities-and-differences-between-internet-gaming-disorder-and-tobacco-use-disorder-a-large-scale-network-study
#38
JOURNAL ARTICLE
Yan-Bin Zheng, Hao-Hao Dong, Min Wang, Weiran Zhou, Xiao Lin, Guang-Heng Dong
Studies have shown that internet gaming disorder (IGD) has the potential to be a type of addiction; however, direct comparisons (similarities and differences) between IGD and traditional addictions remain scarce, especially at the neuroimaging level. Resting-state functional magnetic resonance imaging (fMRI) data were collected from 92 individuals with IGD, 96 individuals with tobacco use disorders (TUDs) and 107 individuals who served as healthy controls (HCs). Independent component analysis (ICA) was performed to explore the similarities and differences among these three groups; Granger causality analysis (GCA) was further performed based on the ICA results to determine potential neural features underlying the differences and similarities among the groups...
March 2022: Addiction Biology
https://read.qxmd.com/read/34727171/laterality-hotspots-in-the-striatum
#39
JOURNAL ARTICLE
Cole Korponay, Elliot A Stein, Thomas J Ross
Striatal loci are connected to both the ipsilateral and contralateral frontal cortex. Normative quantitation of the dissimilarity between striatal loci's hemispheric connection profiles and its spatial variance across the striatum, and assessment of how interindividual differences relate to function, stands to further the understanding of the role of corticostriatal circuits in lateralized functions and the role of abnormal corticostriatal laterality in neurodevelopmental and other neuropsychiatric disorders...
November 2, 2021: Cerebral Cortex
https://read.qxmd.com/read/34667261/effect-of-mglur2-positive-allosteric-modulation-on-frontostriatal-working-memory-activation-in-schizophrenia
#40
JOURNAL ARTICLE
Daniel H Wolf, David Zheng, Christian Kohler, Bruce I Turetsky, Kosha Ruparel, Theodore D Satterthwaite, Mark A Elliott, Mary E March, Alan J Cross, Mark A Smith, Stephen R Zukin, Ruben C Gur, Raquel E Gur
Negative symptoms and cognitive deficits contribute strongly to disability in schizophrenia, and are resistant to existing medications. Recent drug development has targeted enhanced NMDA function by increasing mGluR2/3 signaling. However, the clinical utility of such agents remains uncertain, and markers of brain circuit function are critical for clarifying mechanisms and understanding individual differences in efficacy. We conducted a double-blind, placebo-controlled, randomized cross-over (14 day washout) pilot study evaluating adjunctive use of the mGluR2 positive allosteric modulator AZD8529 (80 mg daily for 3 days), in chronic stable patients with schizophrenia (n = 26 analyzed)...
October 20, 2021: Molecular Psychiatry
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