Charles J Lynch, Immanuel Elbau, Tommy Ng, Aliza Ayaz, Shasha Zhu, Nicola Manfredi, Megan Johnson, Danielle Wolk, Jonathan D Power, Evan M Gordon, Kendrick Kay, Amy Aloysi, Stefano Moia, Cesar Caballero-Gaudes, Lindsay W Victoria, Nili Solomonov, Eric Goldwaser, Benjamin Zebley, Logan Grosenick, Jonathan Downar, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Daniel M Blumberger, Nolan Williams, Faith M Gunning, Conor Liston
Hundreds of neuroimaging studies spanning two decades have revealed differences in brain structure and functional connectivity in depression, but with modest effect sizes, complicating efforts to derive mechanistic pathophysiologic insights or develop biomarkers. 1 Furthermore, although depression is a fundamentally episodic condition, few neuroimaging studies have taken a longitudinal approach, which is critical for understanding cause and effect and delineating mechanisms that drive mood state transitions over time...
August 14, 2023: bioRxiv