keyword
https://read.qxmd.com/read/38459194/frontostriatal-circuit-dysfunction-leads-to-cognitive-inflexibility-in-neuroligin-3-r451c-knockin-mice
#1
JOURNAL ARTICLE
Shen Lin, Cui-Ying Fan, Hao-Ran Wang, Xiao-Fan Li, Jia-Li Zeng, Pei-Xuan Lan, Hui-Xian Li, Bin Zhang, Chun Hu, Junyu Xu, Jian-Hong Luo
Cognitive and behavioral rigidity are observed in various psychiatric diseases, including in autism spectrum disorder (ASD). However, the underlying mechanism remains to be elucidated. In this study, we found that neuroligin-3 (NL3) R451C knockin mouse model of autism (KI mice) exhibited deficits in behavioral flexibility in choice selection tasks. Single-unit recording of medium spiny neuron (MSN) activity in the nucleus accumbens (NAc) revealed altered encoding of decision-related cue and impaired updating of choice anticipation in KI mice...
March 8, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38357782/cortical-and-subcortical-microstructure-integrity-changes-after-repetitive-transcranial-magnetic-stimulation-therapy-in-cocaine-use-disorder-and-relates-to-clinical-outcomes
#2
RANDOMIZED CONTROLLED TRIAL
Jalil Rasgado-Toledo, Victor Issa-Garcia, Ruth Alcalá-Lozano, Eduardo A Garza-Villarreal, Gabriel González-Escamilla
Cocaine use disorder (CUD) is a worldwide public health condition that is suggested to induce pathological changes in macrostructure and microstructure. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as a potential treatment for CUD symptoms. Here, we sought to elucidate whether rTMS induces changes in white matter (WM) microstructure in frontostriatal circuits after 2 weeks of therapy in patients with CUD and to test whether baseline WM microstructure of the same circuits affects clinical improvement...
February 2024: Addiction Biology
https://read.qxmd.com/read/38336862/pramipexole-restores-behavioral-inhibition-in-highly-impulsive-rats-through-a-paradoxical-modulation-of-frontostriatal-networks
#3
JOURNAL ARTICLE
Robin Magnard, Maxime Fouyssac, Yvan M Vachez, Yifeng Cheng, Thibault Dufourd, Carole Carcenac, Sabrina Boulet, Patricia H Janak, Marc Savasta, David Belin, Sebastien Carnicella
Impulse control disorders (ICDs), a wide spectrum of maladaptive behaviors which includes pathological gambling, hypersexuality and compulsive buying, have been recently suggested to be triggered or aggravated by treatments with dopamine D2/3 receptor agonists, such as pramipexole (PPX). Despite evidence showing that impulsivity is associated with functional alterations in corticostriatal networks, the neural basis of the exacerbation of impulsivity by PPX has not been elucidated. Here we used a hotspot analysis to assess the functional recruitment of several corticostriatal structures by PPX in male rats identified as highly (HI), moderately impulsive (MI) or with low levels of impulsivity (LI) in the 5-choice serial reaction time task (5-CSRTT)...
February 9, 2024: Translational Psychiatry
https://read.qxmd.com/read/38298793/neurobehavioral-precursors-of-compulsive-cocaine-seeking-in-dual-frontostriatal-circuits
#4
JOURNAL ARTICLE
Jolyon A Jones, Aude Belin-Rauscent, Bianca Jupp, Maxime Fouyssac, Stephen J Sawiak, Katharina Zuhlsdorff, Peter Zhukovsky, Lara Hebdon, Clara Velazquez Sanchez, Trevor W Robbins, Barry J Everitt, David Belin, Jeffrey W Dalley
BACKGROUND: Only some individuals who use drugs recreationally eventually develop a substance use disorder, characterized in part by the rigid engagement in drug foraging behavior (drug seeking), which is often maintained in the face of adverse consequences (i.e., is compulsive). The neurobehavioral determinants of this individual vulnerability have not been fully elucidated. METHODS: Using a prospective longitudinal study involving 39 male rats, we combined multidimensional characterization of behavioral traits of vulnerability to stimulant use disorder (impulsivity and stickiness) and resilience (sign tracking and sensation seeking/locomotor reactivity to novelty) with magnetic resonance imaging to identify the structural and functional brain correlates of the later emergence of compulsive drug seeking in drug-naïve subjects...
January 2024: Biol Psychiatry Glob Open Sci
https://read.qxmd.com/read/38029279/spontaneous-brain-activity-alterations-in-first-episode-psychosis-a-meta-analysis-of-functional-magnetic-resonance-imaging-studies
#5
JOURNAL ARTICLE
Giulia Cattarinussi, David Antonio Grimaldi, Fabio Sambataro
BACKGROUND AND HYPOTHESIS: Several studies have shown that spontaneous brain activity, including the total and fractional amplitude of low-frequency fluctuations (LFF) and regional homogeneity (ReHo), is altered in psychosis. Nonetheless, neuroimaging results show a high heterogeneity. For this reason, we gathered the extant literature on spontaneous brain activity in first-episode psychosis (FEP), where the effects of long-term treatment and chronic disease are minimal. STUDY DESIGN: A systematic research was conducted on PubMed, Scopus, and Web of Science to identify studies exploring spontaneous brain activity and local connectivity in FEP estimated using functional magnetic resonance imaging...
November 29, 2023: Schizophrenia Bulletin
https://read.qxmd.com/read/37963470/a-stress-sensitive-frontostriatal-circuit-supporting-effortful-reward-seeking-behavior
#6
JOURNAL ARTICLE
Robert N Fetcho, Puja K Parekh, Jolin Chou, Margaux Kenwood, Laura Chalençon, David J Estrin, Megan Johnson, Conor Liston
Effort valuation-a process for selecting actions based on the anticipated value of rewarding outcomes and expectations about the work required to obtain them-plays a fundamental role in decision-making. Effort valuation is disrupted in chronic stress states and is supported by the anterior cingulate cortex (ACC), but the circuit-level mechanisms by which the ACC regulates effort-based decision-making are unclear. Here, we show that ACC neurons projecting to the nucleus accumbens (ACC-NAc) play a critical role in effort valuation behavior in mice...
November 10, 2023: Neuron
https://read.qxmd.com/read/37880631/the-microstructural-change-of-the-brain-and-its-clinical-severity-association-in-pediatric-tourette-syndrome-patients
#7
JOURNAL ARTICLE
Chia-Jui Hsu, Lee Chin Wong, Hsin-Pei Wang, Yi-Chun Chung, Te-Wei Kao, Chen-Hsiang Weng, Wen-Chau Wu, Shinn-Forng Peng, Wen-Yih Isaac Tseng, Wang-Tso Lee
BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments...
October 25, 2023: Journal of Neurodevelopmental Disorders
https://read.qxmd.com/read/37817330/fto-variation-and-early-frontostriatal-brain-development-in-children
#8
JOURNAL ARTICLE
Gita Thapaliya, Poorbita Kundu, Elena Jansen, Marcus A Naymik, Richard Lee, Muriel Marisa Katharina Bruchhage, Viren D'Sa, Matthew J Huentelman, Candace R Lewis, Hans-Georg Müller, Sean C L Deoni, Susan Carnell
OBJECTIVE: Common obesity-associated genetic variants at the fat mass and obesity-associated (FTO) locus have been associated with appetitive behaviors and altered structure and function of frontostriatal brain regions. The authors aimed to investigate the influence of FTO variation on frontostriatal appetite circuits in early life. METHODS: Data were drawn from RESONANCE, a longitudinal study of early brain development. Growth trajectories of nucleus accumbens and frontal lobe volumes, as well as total gray matter and white matter volume, by risk allele (AA) carrier status on FTO single-nucleotide polymorphism rs9939609 were examined in 228 children (102 female, 126 male) using magnetic resonance imaging assessments obtained from infancy through middle childhood...
October 10, 2023: Obesity
https://read.qxmd.com/read/37788828/early-onset-adolescent-binge-drinking-is-associated-with-reduced-white-matter-integrity-in-post-9-11-adult-veterans
#9
JOURNAL ARTICLE
Aubrey A Knoff, Arielle R Knight, David H Salat, Amrita Bedi, Alyssa Currao, Jennifer R Fonda, Regina E McGlinchey, Catherine B Fortier
Adolescence represents a critical period of neural development during which binge drinking (BD) is prevalent. Though prior work has shown that white matter (WM) integrity is susceptible to damage from excessive alcohol intake in adults, the effect of early adolescent BD on WM health in adulthood remains unknown. Veterans with a history of BD onset before age 15 [n = 49; mean age = 31.8 years; early-onset adolescent binge drinkers (EBD)] and after age 15 [n = 290; mean age = 32...
November 11, 2023: Alcohol and Alcoholism
https://read.qxmd.com/read/37741905/cognition-enhancing-and-cognition-impairing-doses-of-psychostimulants-exert-opposing-actions-on-frontostriatal-neural-coding-of-delay-in-working-memory
#10
JOURNAL ARTICLE
Robert C Spencer, Andrea J Martin, David M Devilbiss, Craig W Berridge
The prefrontal cortex (PFC) and extended frontostriatal circuitry play a critical role in executive cognitive processes that guide goal-directed behavior. Dysregulation of frontostriatal-dependent cognition is implicated in a variety of cognitive/behavioral disorders, including addiction and attention deficit hyperactivity disorder (ADHD). Psychostimulants exert dose-dependent and opposing actions on frontostriatal cognitive function. Specifically, low and clinically-relevant doses improve, while higher doses associated with abuse and addiction impair, frontostriatal-dependent cognitive function...
September 23, 2023: Neuropsychopharmacology
https://read.qxmd.com/read/37735237/frontostriatal-circuitry-and-the-tryptophan-kynurenine-pathway-in-major-psychiatric-disorders
#11
JOURNAL ARTICLE
Sugai Liang, Liansheng Zhao, Peiyan Ni, Qiang Wang, Wanjun Guo, Yan Xu, Jia Cai, Shiwan Tao, Xiaojing Li, Wei Deng, Lena Palaniyappan, Tao Li
RATIONALE: An imbalance of the tryptophan kynurenine pathway (KP) commonly occurs in psychiatric disorders, though the neurocognitive and network-level effects of this aberration are unclear. OBJECTIVES: In this study, we examined the connection between dysfunction in the frontostriatal brain circuits, imbalances in the tryptophan kynurenine pathway (KP), and neurocognition in major psychiatric disorders. METHODS: Forty first-episode medication-naive patients with schizophrenia (SCZ), fifty patients with bipolar disorder (BD), fifty patients with major depressive disorder (MDD), and forty-two healthy controls underwent resting-state functional magnetic resonance imaging...
September 22, 2023: Psychopharmacology
https://read.qxmd.com/read/37645792/expansion-of-a-frontostriatal-salience-network-in-individuals-with-depression
#12
Charles J Lynch, Immanuel Elbau, Tommy Ng, Aliza Ayaz, Shasha Zhu, Nicola Manfredi, Megan Johnson, Danielle Wolk, Jonathan D Power, Evan M Gordon, Kendrick Kay, Amy Aloysi, Stefano Moia, Cesar Caballero-Gaudes, Lindsay W Victoria, Nili Solomonov, Eric Goldwaser, Benjamin Zebley, Logan Grosenick, Jonathan Downar, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Daniel M Blumberger, Nolan Williams, Faith M Gunning, Conor Liston
Hundreds of neuroimaging studies spanning two decades have revealed differences in brain structure and functional connectivity in depression, but with modest effect sizes, complicating efforts to derive mechanistic pathophysiologic insights or develop biomarkers. 1 Furthermore, although depression is a fundamentally episodic condition, few neuroimaging studies have taken a longitudinal approach, which is critical for understanding cause and effect and delineating mechanisms that drive mood state transitions over time...
August 14, 2023: bioRxiv
https://read.qxmd.com/read/37577605/visual-sequence-encoding-is-enhanced-by-predictable-music-pairing-via-modulating-medial-temporal-lobe-and-its-connectivity-with-frontostriatal-loops
#13
Yiren Ren, Thackery Brown
UNLABELLED: Listening to music during cognitive activities, such as reading and studying, is very common in human daily life. Therefore, it is important to understand how music interacts with concurrent cognitive functions, particularly memory. Current literature has presented mixed results for whether music can benefit learning in other modalities. Evidence is needed for what neural mechanisms music can tap into to enhance concurrent memory processing. This fMRI study aimed to begin filling this gap by investigating how music of varying predictability levels influences parallel visual sequence encoding performance...
August 3, 2023: bioRxiv
https://read.qxmd.com/read/37505291/higher-striatal-glutamate-in-male-youth-with-internet-gaming-disorder
#14
JOURNAL ARTICLE
Johanna Klar, Johannes Slotboom, Stefan Lerch, Julian Koenig, Roland Wiest, Michael Kaess, Jochen Kindler
Internet gaming disorder (IGD) was included in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a research diagnosis, but little is known about its pathophysiology. Alterations in frontostriatal circuits appear to play a critical role in the development of addiction. Glutamate is considered an essential excitatory neurotransmitter in addictive disorders. This study's aim was to investigate striatal glutamate in youth with IGD compared to healthy controls (HC). Using a cross-sectional design, 25 adolescent male subjects fulfilling DSM-5 criteria for IGD and 26 HC, matched in age, education, handedness and smoking, were included in the analysis...
July 28, 2023: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/37265471/associations-of-lesion-location-structural-disconnection-and-functional-diaschisis-with-depressive-symptoms-post-stroke
#15
JOURNAL ARTICLE
Julian Klingbeil, Max-Lennart Brandt, Anika Stockert, Petra Baum, Karl-Titus Hoffmann, Dorothee Saur, Max Wawrzyniak
INTRODUCTION: Post-stroke depressive symptoms (PSDS) are common and relevant for patient outcome, but their complex pathophysiology is ill understood. It likely involves social, psychological and biological factors. Lesion location is a readily available information in stroke patients, but it is unclear if the neurobiological substrates of PSDS are spatially localized. Building on previous analyses, we sought to determine if PSDS are associated with specific lesion locations, structural disconnection and/or localized functional diaschisis...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37120443/regulation-of-social-interaction-in-mice-by-a-frontostriatal-circuit-modulated-by-established-hierarchical-relationships
#16
JOURNAL ARTICLE
Robert N Fetcho, Baila S Hall, David J Estrin, Alexander P Walsh, Peter J Schuette, Jesse Kaminsky, Ashna Singh, Jacob Roshgodal, Charlotte C Bavley, Viraj Nadkarni, Susan Antigua, Thu N Huynh, Logan Grosenick, Camille Carthy, Lauren Komer, Avishek Adhikari, Francis S Lee, Anjali M Rajadhyaksha, Conor Liston
Social hierarchies exert a powerful influence on behavior, but the neurobiological mechanisms that detect and regulate hierarchical interactions are not well understood, especially at the level of neural circuits. Here, we use fiber photometry and chemogenetic tools to record and manipulate the activity of nucleus accumbens-projecting cells in the ventromedial prefrontal cortex (vmPFC-NAcSh) during tube test social competitions. We show that vmPFC-NAcSh projections signal learned hierarchical relationships, and are selectively recruited by subordinate mice when they initiate effortful social dominance behavior during encounters with a dominant competitor from an established hierarchy...
April 29, 2023: Nature Communications
https://read.qxmd.com/read/36990469/differential-neural-processing-of-value-during-decision-making-in-adults-with-attention-deficit-hyperactivity-disorder-and-healthy-controls
#17
JOURNAL ARTICLE
Chun-Yi Lee, Joshua Oon Soo Goh, Susan Shur-Fen Gau
BACKGROUND: Risk-taking behaviours are observed among adults with attention-deficit/hyperactivity disorder (ADHD). We sought to evaluate altered neural processing of stimuli values associated with risk-taking decision behaviour, distinct from learning requirements, among adults with ADHD. METHODS: Overall, 32 adults with ADHD and 32 healthy controls without ADHD underwent a lottery choice task in a functional magnetic resonance imaging (fMRI) experiment. Participants accepted or rejected stakes with explicit information about variable probabilities of winning or losing points at different magnitudes...
2023: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/36935095/stress-degrades-working-memory-related-frontostriatal-circuit-function
#18
JOURNAL ARTICLE
Craig W Berridge, David M Devilbiss, Andrea J Martin, Robert C Spencer, Rick L Jenison
Goal-directed behavior is dependent on neuronal activity in the prefrontal cortex (PFC) and extended frontostriatal circuitry. Stress and stress-related disorders are associated with impaired frontostriatal-dependent cognition. Our understanding of the neural mechanisms that underlie stress-related cognitive impairment is limited, with the majority of prior research focused on the PFC. To date, the actions of stress across cognition-related frontostriatal circuitry are unknown. To address this gap, the current studies examined the effects of acute noise-stress on the spiking activity of neurons and local field potential oscillatory activity within the dorsomedial PFC (dmPFC) and dorsomedial striatum (dmSTR) in rats engaged in a test of spatial working memory...
March 18, 2023: Cerebral Cortex
https://read.qxmd.com/read/36925960/exposure-to-a-sensory-functional-ingredient-in-the-pig-model-modulates-the-blood-oxygen-level-dependent-brain-responses-to-food-odor-and-acute-stress-during-pharmacological-mri-in-the-frontostriatal-and-limbic-circuits
#19
JOURNAL ARTICLE
Emmanuelle Briard, Yann Serrand, Patrice Dahirel, Régis Janvier, Virginie Noirot, Pierre Etienne, Nicolas Coquery, Pierre-Antoine Eliat, David Val-Laillet
INTRODUCTION: In the present study, we examined the effects of a supplementation with a sensory functional ingredient (FI, D16729, Phodé, France) containing vanillin, furaneol, diacetyl and a mixture of aromatic fatty acids on the behavioural and brain responses of juvenile pigs to acute stress. METHODS: Twenty-four pigs were fed from weaning with a standard granulated feed supplemented with the functional ingredient D16729 (FS animals, N = 12) or a control formulation (CT animals, N = 12)...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/36912046/altered-associations-between-motivated-performance-and-frontostriatal-functional-connectivity-during-reward-anticipation-in-schizophrenia
#20
JOURNAL ARTICLE
Jason Smucny, Timothy D Hanks, Tyler A Lesh, Randall C O'Reilly, Cameron S Carter
BACKGROUND AND HYPOTHESIS: The neuronal mechanisms that underlie deficits in effort cost computation in schizophrenia (SZ) are poorly understood. Given the role of frontostriatal circuits in valence-oriented motivation, we hypothesized that these circuits are either dysfunctional in SZ or do not appropriately predict behavior in SZ when task conditions are difficult and good performance is rewarded. STUDY DESIGN: A total of 52 people with recent onset SZ-spectrum disorders and 48 healthy controls (HCs) performed a 3T fMRI task with 2 valence conditions (rewarded vs neutral) and 2 difficulty conditions...
March 13, 2023: Schizophrenia Bulletin
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