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Frontostriatal circuits

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https://www.readbyqxmd.com/read/29121332/frontostriatal-and-dopamine-markers-of-individual-differences-in-reinforcement-learning-a-multi-modal-investigation
#1
Roselinde H Kaiser, Michael T Treadway, Dustin W Wooten, Poornima Kumar, Franziska Goer, Laura Murray, Miranda Beltzer, Pia Pechtel, Alexis Whitton, Andrew L Cohen, Nathaniel M Alpert, Georges El Fakhri, Marc D Normandin, Diego A Pizzagalli
Prior studies have shown that dopamine (DA) functioning in frontostriatal circuits supports reinforcement learning (RL), as phasic DA activity in ventral striatum signals unexpected reward and may drive coordinated activity of striatal and orbitofrontal regions that support updating of action plans. However, the nature of DA functioning in RL is complex, in particular regarding the role of DA clearance in RL behavior. Here, in a multi-modal neuroimaging study with healthy adults, we took an individual differences approach to the examination of RL behavior and DA clearance mechanisms in frontostriatal learning networks...
October 31, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29094787/functional-dysconnectivity-of-the-limbic-loop-of-frontostriatal-circuits-in-first-episode-treatment-naive-schizophrenia
#2
Pan Lin, Xiaosheng Wang, Bei Zhang, Brian Kirkpatrick, Dost Öngür, James J Levitt, Jorge Jovicich, Shuqiao Yao, Xiang Wang
Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ-related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first-episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects...
November 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29077964/neural-correlates-of-preferred-activities-development-of-an-interest-specific-go-nogo-task
#3
Dienke J Bos, Eliana A Ajodan, Melanie S Silverman, Jonathan P Dyke, Sarah Durston, Jonathan D Power, Rebecca M Jones
The activities we choose to spend our leisure time with are intrinsically motivating and vary across individuals. Yet it is unknown how impulse control or neural activity changes when processing a preferred stimulus related to a hobby or interest. Developing a task that assesses the response to preferred interests is of importance as it would be relevant to a range of psychiatric disorders that have hyper- or hypo-arousal to such cues. During functional Magnetic Resonance Imaging (fMRI), 39 healthy adults completed a novel task to test approach behavior and cognitive control to cues that were personalized to the participants' interests compared to stimuli the participants identified as being of non-interest and colored shapes...
October 25, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28821670/rodent-medial-frontal-control-of-temporal-processing-in-the-dorsomedial-striatum
#4
Eric B Emmons, Benjamin J De Corte, Youngcho Kim, Krystal L Parker, Matthew S Matell, Nandakumar S Narayanan
Although frontostriatal circuits are critical for the temporal control of action, how time is encoded in frontostriatal circuits is unknown. We recorded from frontal and striatal neurons while rats engaged in interval timing, an elementary cognitive function that engages both areas. We report four main results. First, "ramping" activity, a monotonic change in neuronal firing rate across time, is observed throughout frontostriatal ensembles. Second, frontostriatal activity scales across multiple intervals. Third, striatal ramping neurons are correlated with activity of the medial frontal cortex...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28780312/losing-ground-frontostriatal-atrophy-disrupts-language-embodiment-in-parkinson-s-and-huntington-s-disease
#5
REVIEW
Agustina Birba, Indira García-Cordero, Giselle Kozono, Agustina Legaz, Agustín Ibáñez, Lucas Sedeño, Adolfo M García
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the "disrupted motor grounding hypothesis", a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits)...
August 2, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28747260/functional-connectivity-of-the-left-dlpfc-to-striatum-predicts-treatment-response-of-depression-to-tms
#6
Michael Avissar, Fon Powell, Irena Ilieva, Matteo Respino, Faith M Gunning, Conor Liston, Marc J Dubin
BACKGROUND: Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response. Less is known about the relationship between functional connectivity of frontostriatal circuits and treatment response. OBJECTIVE/HYPOTHESIS: We investigated whether baseline functional connectivity of distinct frontostriatal circuits predicted response to TMS...
September 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28557820/features-of-resting-state-electroencephalogram-theta-coherence-in-somatic-symptom-disorder-compared-with-major-depressive-disorder-a-pilot-study
#7
Jaeyoung Ahn, Doug Hyun Han, Ji Sun Hong, Kyoung Joon Min, Young Sik Lee, Bong-Jin Hahm, Sun Mi Kim
OBJECTIVE: Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity between SSD and MDD using quantitative electroencephalography. METHODS: Fifteen patients with SSD (SSD group), 15 patients with MDD (MDD group), and 15 healthy volunteers (healthy control [HC] group) participated in this study...
November 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28486594/apathy-and-impulsivity-in-frontotemporal-lobar-degeneration-syndromes
#8
Claire J Lansdall, Ian T S Coyle-Gilchrist, P Simon Jones, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Katrina M Dick, Trevor W Robbins, James B Rowe
Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology remains elusive. There are critical limitations to previous studies in this area including (i) the assessment of either apathy or impulsivity alone, despite their frequent co-existence; (ii) the assessment of behavioural changes within single diagnostic groups; and (iii) the use of limited sets of tasks or questions that relate to just one aspect of these multifactorial constructs...
June 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28469552/disrupted-topology-of-frontostriatal-circuits-is-linked-to-the-severity-of-insomnia
#9
Feng-Mei Lu, Chun-Hong Liu, Shun-Li Lu, Li-Rong Tang, Chang-Le Tie, Juan Zhang, Zhen Yuan
Insomnia is one of the most common health complaints, with a high prevalence of 30~50% in the general population. In particular, neuroimaging research has revealed that widespread dysfunctions in brain regions involved in hyperarousal are strongly correlated with insomnia. However, whether the topology of the intrinsic connectivity is aberrant in insomnia remains largely unknown. In this study, resting-state functional magnetic resonance imaging (rsfMRI) in conjunction with graph theoretical analysis, was used to construct functional connectivity matrices and to extract the attribute features of the small-world networks in insomnia...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28181956/extrapyramidal-symptoms-in-schizophrenia-evidence-of-blunted-cerebral-hemodynamics-during-a-planning-task
#10
Daniel Schuepbach, Matthias Michel, Gert Wagner, Stefan Duschek, Sabine C Herpertz
Acute extrapyramidal symptoms (EPS) occur frequently in schizophrenia, mostly caused by antidopaminergic substances. There have been no published reports on the impact of acute EPS on cerebral blood flow (CBF) or related measures. In the following study, we examined schizophrenic patients with and without EPS during a planning task and measurements of CBF velocity. Sixteen patients with chronic schizophrenia and 16 healthy participants performed a planning paradigm during bilateral functional transcranial Doppler sonography of the middle cerebral arteries...
July 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28154786/social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntington-s-disease
#11
Ida Unmack Larsen, Tua Vinther-Jensen, Jørgen Erik Nielsen, Anders Gade, Asmus Vogel
OBJECTIVE: Huntington's disease (HD) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social cognition in a large consecutive cohort of HD patients. METHOD: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report questionnaire about current status of perceived psychological distress (the Symptom Checklist-90-Revised (SCL-90-R))...
December 28, 2016: PLoS Currents
https://www.readbyqxmd.com/read/28123020/dynamic-reconfiguration-of-visuomotor-related-functional-connectivity-networks
#12
Andrea Brovelli, Jean-Michel Badier, Francesca Bonini, Fabrice Bartolomei, Olivier Coulon, Guillaume Auzias
Cognitive functions arise from the coordination of large-scale brain networks. However, the principles governing interareal functional connectivity dynamics (FCD) remain elusive. Here, we tested the hypothesis that human executive functions arise from the dynamic interplay of multiple networks. To do so, we investigated FCD mediating a key executing function, known as arbitrary visuomotor mapping, using brain connectivity analyses of high-gamma activity recorded using MEG and intracranial EEG. Visuomotor mapping was found to arise from the dynamic interplay of three partly overlapping cortico-cortical and cortico-subcortical functional connectivity (FC) networks...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28118989/perspectives-on-fronto-fugal-circuitry-from-human-imaging-of-alcohol-use-disorders
#13
REVIEW
Natalie M Zahr, Adolf Pfefferbaum, Edith V Sullivan
Descriptions of the cognitive functions affected by alcohol use disorders (AUD) often highlight dysfunction of executive processes such attention, inhibitory control, working memory, and cognitive flexibility. Such complex cognitive functions have historically been ascribed to the prefrontal cortex. AUD, however, disrupts extensive areas of the brain. Structural and functional MRI studies suggest a central role for degradation of circuitry originating in the prefrontal cortex including nodes in widespread brain regions...
August 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28073327/nonmotor-symptoms-in-parkinson-disease-a-descriptive-review-on-social-cognition-ability
#14
REVIEW
Rosanna Palmeri, Viviana Lo Buono, Francesco Corallo, Maria Foti, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms. Nonmotor symptoms include cognitive deficits and impairment in emotions recognition ability associated with loss of dopaminergic neurons in the substantia nigra and with alteration in frontostriatal circuits. In this review, we analyzed the studies on social cognition ability in patients with PD. We searched on PubMed and Web of Science databases and screening references of included studied and review articles for additional citations...
March 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28031992/striatal-morphology-correlates-with-frontostriatal-electrophysiological-motor-processing-in-huntington-s-disease-an-image-hd-study
#15
Lauren M Turner, David Jakabek, Fiona A Wilkes, Rodney J Croft, Andrew Churchyard, Mark Walterfang, Dennis Velakoulis, Jeffrey C L Looi, Nellie Georgiou-Karistianis, Deborah Apthorp
BACKGROUND: Huntington's disease (HD) causes progressive atrophy to the striatum, a critical node in frontostriatal circuitry. Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral frontostriatal circuits, and structural integrity of the striatum itself. We aimed to investigate whether size and shape of the striatum as a measure of frontostriatal circuit structural integrity was correlated with functional frontostriatal electrophysiological neural premotor processing (contingent negative variation, CNV), to better understand motoric structure-function relationships in early HD...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28018207/neural-correlates-for-apathy-frontal-prefrontal-and-parietal-cortical-subcortical-circuits
#16
REVIEW
Rita Moretti, Riccardo Signori
Apathy is an uncertain nosographical entity, which includes reduced motivation, abulia, decreased empathy, and lack of emotional involvement; it is an important and heavy-burden clinical condition which strongly impacts in everyday life events, affects the common daily living abilities, reduced the inner goal directed behavior, and gives the heaviest burden on caregivers. Is a quite common comorbidity of many neurological disease, However, there is no definite consensus on the role of apathy in clinical practice, no definite data on anatomical circuits involved in its development, and no definite instrument to detect it at bedside...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27769568/specific-frontostriatal-circuits-for-impaired-cognitive-flexibility-and-goal-directed-planning-in-obsessive-compulsive-disorder-evidence-from-resting-state-functional-connectivity
#17
Matilde M Vaghi, Petra E Vértes, Manfred G Kitzbichler, Annemieke M Apergis-Schoute, Febe E van der Flier, Naomi A Fineberg, Akeem Sule, Rashid Zaman, Valerie Voon, Prantik Kundu, Edward T Bullmore, Trevor W Robbins
BACKGROUND: A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and cognitive flexibility to underlying resting-state functional connectivity. METHODS: Multiecho resting-state acquisition, combined with micromovement correction by blood oxygen level-dependent sensitive independent component analysis, was used to obtain in vivo measures of functional connectivity in 44 OCD patients and 43 healthy comparison subjects...
April 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/27757078/functional-connectivity-abnormalities-of-brain-regions-with-structural-deficits-in-young-adult-male-smokers
#18
Limei Bu, Dahua Yu, Shaoping Su, Yao Ma, Karen M von Deneen, Lin Luo, Jinquan Zhai, Bo Liu, Jiadong Cheng, Yanyan Guan, Yangding Li, Yanzhi Bi, Ting Xue, Xiaoqi Lu, Kai Yuan
Smoking is one of the most prevalent dependence disorders. Previous studies have detected structural and functional deficits in smokers. However, few studies focused on the changes of resting state functional connectivity (RSFC) of the brain regions with structural deficits in young adult smokers. Twenty-six young adult smokers and 26 well-matched healthy non-smokers participated in our study. Voxel-based morphometry (VBM) and RSFC were employed to investigate the structural and functional changes in young adult smokers...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27707968/role-of-prefrontal-cortex-in-learning-and-generalizing-hierarchical-rules-in-8-month-old-infants
#19
Denise M Werchan, Anne G E Collins, Michael J Frank, Dima Amso
Recent research indicates that adults and infants spontaneously create and generalize hierarchical rule sets during incidental learning. Computational models and empirical data suggest that, in adults, this process is supported by circuits linking prefrontal cortex (PFC) with striatum and their modulation by dopamine, but the neural circuits supporting this form of learning in infants are largely unknown. We used near-infrared spectroscopy to record PFC activity in 8-month-old human infants during a simple audiovisual hierarchical-rule-learning task...
October 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27694879/ageing-increases-reliance-on-sensorimotor-prediction-through-structural-and-functional-differences-in-frontostriatal-circuits
#20
Noham Wolpe, James N Ingram, Kamen A Tsvetanov, Linda Geerligs, Rogier A Kievit, Richard N Henson, Daniel M Wolpert, James B Rowe
The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation-a reduction in the perceived intensity of sensations from self-generated compared with external actions. Here we show that sensorimotor attenuation occurs in 98% of adults in a population-based cohort (n=325; 18-88 years; the Cambridge Centre for Ageing and Neuroscience)...
October 3, 2016: Nature Communications
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