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Frontostriatal circuits

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https://www.readbyqxmd.com/read/29688871/altered-cortical-thickness-and-attentional-deficits-in-adolescent-girls-and-women-with-bulimia-nervosa
#1
Laura A Berner, Mihaela Stefan, Seonjoo Lee, Zhishun Wang, Kate Terranova, Evelyn Attia, Rachel Marsh
BACKGROUND: Frontostriatal and frontoparietal abnormalities likely contribute to deficits in control and attentional processes in individuals with bulimia nervosa and to the persistence of dysregulated eating across development. This study assessed these processes and cortical thickness in a large sample of adolescent girls and women with bulimia nervosa compared with healthy controls. METHODS: We collected anatomical MRI data from adolescent girls and women (ages 12-38 yr) with full or subthreshold bulimia nervosa and age-matched healthy controls who also completed the Conners Continuous Performance Test-II (CPT-II)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29593581/enhanced-amygdala-striatal-functional-connectivity-during-the-processing-of-cocaine-cues-in-male-cocaine-users-with-a-history-of-childhood-trauma
#2
Anne Marije Kaag, Liesbeth Reneman, Judith Homberg, Wim van den Brink, Guido A van Wingen
Background and aims: Childhood trauma is associated with increased levels of anxiety later in life, an increased risk for the development of substance use disorders, and neurodevelopmental abnormalities in the amygdala and frontostriatal circuitry. The aim of this study was to investigate the (neurobiological) link among childhood trauma, state anxiety, and amygdala-frontostriatal activity in response to cocaine cues in regular cocaine users. Methods: In this study, we included 59 non-treatment seeking regular cocaine users and 58 non-drug using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29487542/cognition-as-a-therapeutic-target-in-the-suicidal-patient-approach
#3
REVIEW
Antônio Geraldo da Silva, Leandro Fernandes Malloy-Diniz, Marina Saraiva Garcia, Carlos Guilherme Silva Figueiredo, Renata Nayara Figueiredo, Alexandre Paim Diaz, António Pacheco Palha
The current considerations about completed suicides and suicide attempts in different cultures call the attention of professionals to this serious public health problem. Integrative approaches have shown that the confluence of multiple biological and social factors modulate various psychopathologies and dysfunctional behaviors, such as suicidal behavior. Considering the level of intermediate analysis, personality traits and cognitive functioning are also of great importance for understanding the suicide phenomenon...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29486865/motivational-deficits-in-schizophrenia-are-associated-with-reduced-differentiation-between-gain-and-loss-avoidance-feedback-in-the-striatum
#4
James A Waltz, Ziye Xu, Elliot C Brown, Rebecca R Ruiz, Michael J Frank, James M Gold
BACKGROUND: The current study was designed to test the hypothesis that motivational deficits in schizophrenia (SZ) are tied to a reduced ability to differentially signal gains and instances of loss-avoidance in the brain, leading to reduced ability to form adaptive representations of expected value. METHODS: We administered a reinforcement learning paradigm to 27 medicated SZ patients and 27 control subjects in which participants learned three probabilistic discriminations...
March 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29468065/neuroimaging-in-bulimia-nervosa-and-binge-eating-disorder-a-systematic-review
#5
REVIEW
Brooke Donnelly, Stephen Touyz, Phillipa Hay, Amy Burton, Janice Russell, Ian Caterson
Objective: In recent decades there has been growing interest in the use of neuroimaging techniques to explore the structural and functional brain changes that take place in those with eating disorders. However, to date, the majority of research has focused on patients with anorexia nervosa. This systematic review addresses a gap in the literature by providing an examination of the published literature on the neurobiology of individuals who binge eat; specifically, individuals with bulimia nervosa (BN) and binge eating disorder (BED)...
2018: Journal of Eating Disorders
https://www.readbyqxmd.com/read/29423814/connectivity-based-characterisation-of-subcortical-grey-matter-pathology-in-frontotemporal-dementia-and-als-a-multimodal-neuroimaging-study
#6
Peter Bede, Taha Omer, Eoin Finegan, Rangariroyashe H Chipika, Parameswaran M Iyer, Mark A Doherty, Alice Vajda, Niall Pender, Russell L McLaughlin, Siobhan Hutchinson, Orla Hardiman
Frontotemporal dementia (FTD) phenotypes have distinctive and well-established cortical signatures, but their subcortical grey matter profiles are poorly characterised. The comprehensive characterisation of striatal and thalamic pathology along the ALS-FTD spectrum is particularly timely, as dysfunction of frontostriatal and cortico-thalamic networks contribute to phenotype-defining cognitive, behavioral, and motor deficits. Ten patients with behavioral-variant FTD, 11 patients with non-fluent-variant primary progressive aphasia, 5 patients with semantic-variant primary progressive aphasia, 14 ALS-FTD patients with C9orf72 hexanucleotide expansions, 12 ALS-FTD patients without hexanucleotide repeats, 36 ALS patients without cognitive impairment and 50 healthy controls were included in a prospective neuroimaging study...
February 8, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29336774/altered-cortical-thickness-and-attentional-deficits-in-adolescent-girls-and-women-with-bulimia-nervosa
#7
Laura A Berner, Mihaela Stefan, Seonjoo Lee, Zhishun Wang, Kate Terranova, Evelyn Attia, Rachel Marsh
BACKGROUND: Frontostriatal and frontoparietal abnormalities likely contribute to deficits in control and attentional processes in individuals with bulimia nervosa and to the persistence of dysregulated eating across development. This study assessed these processes and cortical thickness in a large sample of adolescent girls and women with bulimia nervosa compared with healthy controls. METHODS: We collected anatomical MRI data from adolescent girls and women (ages 12-38 yr) with full or subthreshold bulimia nervosa and age-matched healthy controls who also completed the Conners Continuous Performance Test-II (CPT-II)...
January 12, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29170982/subcallosal-and-heubner-artery-infarcts-following-surgical-repair-of-an-anterior-communicating-artery-aneurysm-a-causal-relationship-with-postoperative-amnesia-and-long-term-outcome
#8
Shunji Mugikura, Hirokazu Kikuchi, Miki Fujimura, Etsuro Mori, Shoki Takahashi, Kei Takase
Since the 1950s, amnesia or memory impairment has been repeatedly reported in patients following surgical repair of anterior communicating artery (ACoA) aneurysms. Postoperative infarctions following surgical repair of ACoA aneurysms are classified as involvement of the subcallosal artery (the largest unpaired perforator of the ACoA), the recurrent artery of Heubner (RAH), or a combination of both. Postoperative amnesia can seriously affect the patient's quality of life, thus prompting physicians to discuss the symptomatology of the three infarction patterns...
February 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29167834/hypoactivation-and-dysconnectivity-of-a-frontostriatal-circuit-during-goal-directed-planning-as-an-endophenotype-for-obsessive-compulsive-disorder
#9
Matilde M Vaghi, Adam Hampshire, Naomi A Fineberg, Muzaffer Kaser, Annette B Brühl, Barbara J Sahakian, Samuel R Chamberlain, Trevor W Robbins
Background: The symptoms of obsessive-compulsive disorder (OCD) have been postulated to result from impaired executive functioning and excessive habit formation at the expense of goal-directed control and have been objectively demonstrated using neuropsychological tests in such patients. This study tested whether there is functional hypoactivation as well as dysconnectivity of discrete frontostriatal pathways during goal-directed planning in patients with OCD and in their unaffected first-degree relatives...
November 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29121332/frontostriatal-and-dopamine-markers-of-individual-differences-in-reinforcement-learning-a-multi-modal-investigation
#10
Roselinde H Kaiser, Michael T Treadway, Dustin W Wooten, Poornima Kumar, Franziska Goer, Laura Murray, Miranda Beltzer, Pia Pechtel, Alexis Whitton, Andrew L Cohen, Nathaniel M Alpert, Georges El Fakhri, Marc D Normandin, Diego A Pizzagalli
Prior studies have shown that dopamine (DA) functioning in frontostriatal circuits supports reinforcement learning (RL), as phasic DA activity in ventral striatum signals unexpected reward and may drive coordinated activity of striatal and orbitofrontal regions that support updating of action plans. However, the nature of DA functioning in RL is complex, in particular regarding the role of DA clearance in RL behavior. Here, in a multi-modal neuroimaging study with healthy adults, we took an individual differences approach to the examination of RL behavior and DA clearance mechanisms in frontostriatal learning networks...
October 31, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29094787/functional-dysconnectivity-of-the-limbic-loop-of-frontostriatal-circuits-in-first-episode-treatment-naive-schizophrenia
#11
Pan Lin, Xiaosheng Wang, Bei Zhang, Brian Kirkpatrick, Dost Öngür, James J Levitt, Jorge Jovicich, Shuqiao Yao, Xiang Wang
Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ-related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first-episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects...
February 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29077964/neural-correlates-of-preferred-activities-development-of-an-interest-specific-go-nogo-task
#12
Dienke J Bos, Eliana L Ajodan, Melanie R Silverman, Jonathan P Dyke, Sarah Durston, Jonathan D Power, Rebecca M Jones
The activities we choose to spend our leisure time with are intrinsically motivating and vary across individuals. Yet it is unknown how impulse control or neural activity changes when processing a preferred stimulus related to a hobby or interest. Developing a task that assesses the response to preferred interests is of importance as it would be relevant to a range of psychiatric disorders that have hyper- or hypo-arousal to such cues. During functional Magnetic Resonance Imaging (fMRI), 39 healthy adults completed a novel task to test approach behavior and cognitive control to cues that were personalized to the participants' interests compared to stimuli the participants identified as being of non-interest and colored shapes...
December 1, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28821670/rodent-medial-frontal-control-of-temporal-processing-in-the-dorsomedial-striatum
#13
Eric B Emmons, Benjamin J De Corte, Youngcho Kim, Krystal L Parker, Matthew S Matell, Nandakumar S Narayanan
Although frontostriatal circuits are critical for the temporal control of action, how time is encoded in frontostriatal circuits is unknown. We recorded from frontal and striatal neurons while rats engaged in interval timing, an elementary cognitive function that engages both areas. We report four main results. First, "ramping" activity, a monotonic change in neuronal firing rate across time, is observed throughout frontostriatal ensembles. Second, frontostriatal activity scales across multiple intervals...
September 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28780312/losing-ground-frontostriatal-atrophy-disrupts-language-embodiment-in-parkinson-s-and-huntington-s-disease
#14
REVIEW
Agustina Birba, Indira García-Cordero, Giselle Kozono, Agustina Legaz, Agustín Ibáñez, Lucas Sedeño, Adolfo M García
Within the language domain, movement disorders triggered by frontostriatal damage are characterized by deficits in action verbs, motor-language coupling, and syntax. However, these impairments have not been jointly interpreted under a unifying rationale or integratively assessed in terms of possible clinical implications. To bridge these gaps, here we introduce the "disrupted motor grounding hypothesis", a new framework to conceive such impairments as disturbances of embodied mechanisms (high-order domains based on the recycling of functionally germane sensorimotor circuits)...
September 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28747260/functional-connectivity-of-the-left-dlpfc-to-striatum-predicts-treatment-response-of-depression-to-tms
#15
Michael Avissar, Fon Powell, Irena Ilieva, Matteo Respino, Faith M Gunning, Conor Liston, Marc J Dubin
BACKGROUND: Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response. Less is known about the relationship between functional connectivity of frontostriatal circuits and treatment response. OBJECTIVE/HYPOTHESIS: We investigated whether baseline functional connectivity of distinct frontostriatal circuits predicted response to TMS...
September 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28557820/features-of-resting-state-electroencephalogram-theta-coherence-in-somatic-symptom-disorder-compared-with-major-depressive-disorder-a-pilot-study
#16
Jaeyoung Ahn, Doug Hyun Han, Ji Sun Hong, Kyoung Joon Min, Young Sik Lee, Bong-Jin Hahm, Sun Mi Kim
OBJECTIVE: Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity between SSD and MDD using quantitative electroencephalography. METHODS: Fifteen patients with SSD (SSD group), 15 patients with MDD (MDD group), and 15 healthy volunteers (healthy control [HC] group) participated in this study...
November 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28486594/apathy-and-impulsivity-in-frontotemporal-lobar-degeneration-syndromes
#17
Claire J Lansdall, Ian T S Coyle-Gilchrist, P Simon Jones, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Katrina M Dick, Trevor W Robbins, James B Rowe
Apathy and impulsivity are common and disabling consequences of frontotemporal lobar degeneration. They cause substantial carer distress, but their aetiology remains elusive. There are critical limitations to previous studies in this area including (i) the assessment of either apathy or impulsivity alone, despite their frequent co-existence; (ii) the assessment of behavioural changes within single diagnostic groups; and (iii) the use of limited sets of tasks or questions that relate to just one aspect of these multifactorial constructs...
June 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28469552/disrupted-topology-of-frontostriatal-circuits-is-linked-to-the-severity-of-insomnia
#18
Feng-Mei Lu, Chun-Hong Liu, Shun-Li Lu, Li-Rong Tang, Chang-Le Tie, Juan Zhang, Zhen Yuan
Insomnia is one of the most common health complaints, with a high prevalence of 30~50% in the general population. In particular, neuroimaging research has revealed that widespread dysfunctions in brain regions involved in hyperarousal are strongly correlated with insomnia. However, whether the topology of the intrinsic connectivity is aberrant in insomnia remains largely unknown. In this study, resting-state functional magnetic resonance imaging (rsfMRI) in conjunction with graph theoretical analysis, was used to construct functional connectivity matrices and to extract the attribute features of the small-world networks in insomnia...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28181956/extrapyramidal-symptoms-in-schizophrenia-evidence-of-blunted-cerebral-hemodynamics-during-a-planning-task
#19
Daniel Schuepbach, Matthias Michel, Gert Wagner, Stefan Duschek, Sabine C Herpertz
Acute extrapyramidal symptoms (EPS) occur frequently in schizophrenia, mostly caused by antidopaminergic substances. There have been no published reports on the impact of acute EPS on cerebral blood flow (CBF) or related measures. In the following study, we examined schizophrenic patients with and without EPS during a planning task and measurements of CBF velocity. Sixteen patients with chronic schizophrenia and 16 healthy participants performed a planning paradigm during bilateral functional transcranial Doppler sonography of the middle cerebral arteries...
July 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28154786/social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntington-s-disease
#20
Ida Unmack Larsen, Tua Vinther-Jensen, Jørgen Erik Nielsen, Anders Gade, Asmus Vogel
OBJECTIVE: Huntington's disease (HD) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social cognition in a large consecutive cohort of HD patients. METHOD: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report questionnaire about current status of perceived psychological distress (the Symptom Checklist-90-Revised (SCL-90-R))...
December 28, 2016: PLoS Currents
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