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Glut-1

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https://www.readbyqxmd.com/read/28212524/role-of-nrf2-and-protective-effects-of-metformin-against-tobacco-smoke-induced-cerebrovascular-toxicity
#1
Shikha Prasad, Ravi K Sajja, Mohammad Abul Kaisar, Jee Hyun Park, Heidi Villalba, Taylor Liles, Thomas Abbruscato, Luca Cucullo
Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of developing type-2 diabetes mellitus (2DM) with which it shares other pathogenic traits including the high risk of cerebrovascular and neurological disorders like stroke via ROS generation, inflammation, and blood-brain barrier (BBB) impairment. Herein we provide evidence of the role played by nuclear factor erythroid 2-related factor (Nrf2) in CS-induced cerebrobvascular/BBB impairments and how these cerebrovascular harmful effects can be circumvented by the use of metformin (MF; a widely prescribed, firstline anti-diabetic drug) treatment...
February 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28205432/fluorescent-hexose-conjugates-establish-stringent-stereochemical-requirement-by-glut5-for-recognition-and-transport-of-monosaccharides
#2
Olivier-Mohamad Soueidan, Thomas W Scully, Jatinder Kaur, Rashmi Panigrahi, Alexandr Belovodskiy, Victor Do, Carson D Matier, M Joanne Lemieux, Frank Wuest, Chris Cheeseman, F G West
The specificity characteristics of transporters can be exploited for the development of novel diagnostic therapeutic probes. The facilitated hexose transporter family (GLUTs) has a distinct set of preferences for monosaccharide substrates, and while some are expressed ubiquitously (e.g., GLUT1), others are quite tissue specific (e.g., GLUT5, which is overexpressed in some breast cancer tissues). While these differences have enabled the development of new molecular probes based upon hexose- and tissue-selective uptake, substrate design for compounds targeting these GLUT transporters has been encumbered by a limited understanding of the molecular interactions at play in hexose binding and transport...
February 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28180987/preoperative-high-maximum-standardized-uptake-value-in-association-with-glucose-transporter-1-predicts-poor-prognosis-in-pancreatic-cancer
#3
Akira Chikamoto, Risa Inoue, Yoshiaki Komohara, Kentaro Sakamaki, Daisuke Hashimoto, Shinya Shiraishi, Hiroshi Takamori, Yo-Ichi Yamashita, Naoya Yoshida, Takeharu Yamanaka, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: The diagnosis of malignant diseases worldwide has been determined using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET). Glucose transporter type 1 (Glut-1) is a key protein associated with the accumulation of FDG in cancer cells. This study evaluated the relationship between Glut-1 expression and FDG accumulation to determine the usefulness of FDG-PET for prediction of long-term outcomes of pancreatic cancer. METHODS: The expression of Glut-1 was immunohistochemically examined in 138 surgically resected pancreatic cancer specimens...
February 8, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28178665/prognostic-value-of-glut-1-expression-in-pancreatic-cancer-results-from-538-patients
#4
Gaowa Sharen, Yaojun Peng, Haidong Cheng, Yang Liu, Yonghong Shi, Jian Zhao
OBJECTIVE: Previous studies have suggested a correlation between glucose transporter-1 (GLUT-1) expression and survival outcomes in pancreatic cancer, although the results were inconsistent. We subsequently carried out a meta-analysis, with the aim of comprehensively reevaluating the associations between GLUT-1 expression and overall survival (OS) and other clinical features of pancreatic cancer. RESULTS: Eight studies, with a total of 538 cases, were included in the final meta-analysis...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28173667/-expression-of-hypoxia-inducible-factor-1%C3%AE-glucose-transporter-1-and-lactate-dehydrogenase-5-in-colorectal-cancer-and-clinicopathologic-significance
#5
T Y Yang, L S Hao, D Z Guo
Objective: To investigate the expression and clinicopathological significance of hypoxia-inducible factor 1 alpha (HIF-1α), glucose transporter 1(GLUT-1) and lactate dehydrogenase(LDH)-5 in colorectal cancer. Methods: The expression levels of HIF-1α, GLUT-1 and LDH-5 were detected by immunohistochemical staining in 142 specimens of human carcinoma in comparison with adjacent normal tissues. Results: The expression levels of HIF-1α(78.2%, 111/142), GLUT-1(75.4%, 107/142) and LDH-5(68.3%, 97/142) were higher in tumor tissues than in adjacent normal tissues(14...
February 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28143735/pharmacological-efficacy-of-fgf21-analogue-liraglutide-and-insulin-glargine-in-treatment-of-type-2-diabetes
#6
Xianlong Ye, Jianying Qi, Dan Yu, Yunzhou Wu, Shenglong Zhu, Shujie Li, Qiang Wu, Guiping Ren, Deshan Li
Fibroblast growth factor 21 (FGF21) is a promising regulator of glucose and lipid metabolism with multiple beneficial effects including hypoglycemic and lipid-lowering. Previous studies have reported that FGF21 is expected to become a new drug for treatment of diabetes. Liraglutide and insulin glargine are the two representative anti-diabetic biological drugs. In the current study, we aim to compare the long-term pharmacological efficacy of mFGF21 (an FGF21 analogue), liraglutide and insulin glargine in type 2 diabetic db/db mice...
January 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28121621/the-expression-of-the-bpifb4-and-cxcr4-associates-with-sustained-health-in-long-living-individuals-from-cilento-italy
#7
Gaia Spinetti, Elena Sangalli, Claudia Specchia, Francesco Villa, Chiara Spinelli, Rita Pipolo, Albino Carrizzo, Simona Greco, Christine Voellenkle, Carmine Vecchione, Paolo Madeddu, Fabio Martelli, Annibale Alessandro Puca
: The study of the health status in long-living individuals (LLIs) may help identifying health-span and life-span determinants. BPI-Fold-Containing-Family-B-Member-4 (BPIFB4) protein is higher in healthy vs. non-healthy (frail) LLIs serum and its longevity-associated variant forced expression improves cardiovascular outcomes in ischemia mice models. Thus, we tested the association of BPIFB4 and ischemia-responding HIF-1α pathway components (i.e. CXCR4, AK3, ALDO-C, ADM, VEGF-A, GLUT-1 and miR-210) with human life-span and health-span by analyzing mRNA expression in circulating mononuclear cells (MNCs) of LLIs (N=14 healthy; N=31 frail) and young controls (N=63)...
January 22, 2017: Aging
https://www.readbyqxmd.com/read/28111788/benign-vascular-lesions-of-the-lips-diagnostic-approach
#8
Priscila Lie Tobouti, Isabel Olegário, Suzana Cantanhede Orsini Machado de Sousa
BACKGROUND: Although not rare, vascular lesions occurring in the lips sometimes poses a difficult in properly diagnosing and handling them. In the present study vascular lesions occurring in the lips were retrieved from an Oral Pathology Service. METHODS: Among 5,600 biopsies, 131 cases were found. The following diagnoses were attributed: caliber-persistent artery, infantile hemangioma, vascular malformation, venous lake, thrombus, papillary endothelial hyperplasia, and pyogenic granuloma...
January 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28095750/effects-of-pre-germinated-brown-rice-treatment-high-fat-diet-induced-metabolic-syndrome-in-c57bl-6j-mice
#9
Hsueh-Wei Yen, Hui-Li Lin, Chi-Long Hao, Fu-Chih Chen, Chun-Yun Chen, Jia-Hao Chen, Kuo-Ping Shen
To investigate using pre-germinated brown rice (PGBR) to treat metabolic syndrome, we fed one group of mice standard-regular-diet (SRD) for 20 weeks and another group of mice high-fat-diet (HFD) for 16 weeks. We subdivided them into HFD group and HFD + PGBR group whose dietary carbohydrate was replaced with PGBR for 4 weeks. The HFD group gained more weight, had higher blood pressure, heart rate, blood glucose and lipids, liver levels of TG, feces TG and bile acid, lower adipose levels of adipocytokine, lower skeletal muscle IR, IRS-1, IRS-2, PI3 K, Akt/PKB, GLUT-1, GLUT-4, GCK and PPAR-γ; higher liver SREBP-1, SCD-1, FAS, HMGCR, LDLR, CYP7α1 and PPAR-α, and higher adipose SREBP-1, SCD-1, FAS, and lower adipose PPAR-α and adiponectin...
January 18, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28073046/olanzapine-and-aripiprazole-differentially-affect-glucose-uptake-and-energy-metabolism-in-human-mononuclear-blood-cells
#10
Britta Stapel, Alexandra Kotsiari, Michaela Scherr, Denise Hilfiker-Kleiner, Stefan Bleich, Helge Frieling, Kai G Kahl
The use of antipsychotics carries the risk of metabolic side effects, such as weight gain and new onset type-2 diabetes mellitus. The mechanisms of the observed metabolic alterations are not fully understood. We compared the effects of two atypical antipsychotics, one known to favor weight gain (olanzapine), the other not (aripiprazole), on glucose metabolism. Primary human peripheral blood mononuclear cells (PBMC) were isolated and stimulated with olanzapine or aripiprazole for 72 h. Cellular glucose uptake was analyzed in vitro by 18F-FDG uptake...
December 22, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28068944/the-acceleration-of-glucose-accumulation-in-renal-cell-carcinoma-assessed-by-fdg-pet-ct-demonstrated-acquisition-of-resistance-to-tyrosine-kinase-inhibitor-therapy
#11
Noboru Nakaigawa, Keiichi Kondo, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Kazuki Kobayashi, Koichi Shioi, Ichiro Ikeda, Takeshi Kishida, Tomohiro Kaneta, Ryogo Minamimoto, Ukihide Tateishi, Tomio Inoue, Masahiro Yao
BACKGROUND: Tyrosine-kinase inhibitor (TKI) targeting angiogenesis improves the prognosis of patients with metastatic renal cell carcinoma (RCC), but its effect is temporary. In order to understand the mechanism by which RCC acquires resistance to TKI, we investigated the change of glucose accumulation in RCC by FDG PET/CT when they demonstrated progression disease (PD) against TKI. METHODS: We monitored the FDG accumulation in RCC of 38 patients treated with TKI by 162 PET/CT sequentially until they were judged to demonstrate PD...
January 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28053105/epstein-barr-virus-encoded-latent-membrane-protein-1-upregulates-glucose-transporter-1-transcription-via-the-mtorc1-nf-%C3%AE%C2%BAb-signaling-pathways
#12
Jun Zhang, Lin Jia, Weitao Lin, Yim Ling Yip, Kwok Wai Lo, Victoria Ming Yi Lau, Dandan Zhu, Chi Man Tsang, Yuan Zhou, Wen Deng, Hong Lok Lung, Maria Li Lung, Lai Man Cheung, Sai Wah Tsao
: Accumulating evidence indicates that oncogenic viral protein exerts a crucial role in activating aerobic glycolysis during tumorigenesis, but the underlying mechanisms are largely undefined. The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a trans-membrane protein with potent cell signaling properties and has tumorigenic transformation property. Activation of NF-κB is a major signaling pathway mediating many downstream transformation properties of LMP1. Here we report that activation of mTORC1 by LMP1 is a key modulator for activation of NF-κB signaling to mediate aerobic glycolysis...
January 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28052033/glut-1-overexpression-as-an-unfavorable-prognostic-biomarker-in-patients-with-colorectal-cancer
#13
Jing Yang, Jing Wen, Tian Tian, Zhongsheng Lu, Yao Wang, Zikai Wang, Xiangdong Wang, Yunsheng Yang
BACKGROUND: Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis. MATERIALS AND METHODS: Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures. RESULTS: A total of 14 studies with 2,077 patients were included in this meta-analysis...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28034640/oral-perineurioma-clinicopathologic-features-from-two-cases-and-review-of-literature
#14
Wagner Gomes da Silva, Marisol Martínez Martínez, Águida Maria Menezes Aguiar Miranda, Roberto Bastos Silva, Henrique Martins da Silveira, Oslei Paes de Almeida, Fábio Ramôa Pires
The present study reports two cases of oral perineuriomas, including a clinicopathologic review of the 39 published cases (17 intraneural and 22 extraneural perineuriomas) in the English language literature. In the first case, the tumor occurred in an 84-year-old male as a painless, asymptomatic, 20-mm submucosal nodule on the right lower mucobuccal fold near to the premolar area. In the second case, a 46-year-old female presented with a painless, 25-mm, slow-growing, fibrous, pedunculated nodule on the right buccal mucosa...
March 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28028797/glut1-mct1-4-and-cd147-overexpression-supports-the-metabolic-reprogramming-in-papillary-renal-cell-carcinoma
#15
L M C A Almeida, R Silva, B Cavadas, J Lima, L Pereira, P Soares, M Sobrinho-Simões, J M Lopes, V Máximo
Papillary Renal Cell carcinoma (pRCC) is the second most common type of RCC, accounting for about 15% of all RCCs. Surgical excision is the main treatment option. Still, 10 - 15 % of clinically localized tumours will recur and/or develop metastasis early after surgery, and no reliable prognostic biomarkers are available to identify them. It is known that pRCC cells rely on high rates of aerobic glycolysis, characterized by the up-regulation of many proteins and enzymes related with the glycolytic pathway. However, a metabolic signature enabling the identification of advanced pRCC tumours remains to be discovered...
December 28, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/28018440/glucose-transport-1-deficiency-presenting-as-infantile-spasms-with-a-mutation-identified-in-exon-9-of-slc2a1
#16
Hyun Hee Lee, Yun Jung Hur
Glucose transport 1 (GLUT-1) deficiency is a rare syndrome caused by mutations in the glucose transporter 1 gene (SLC2A1) and is characterized by early-onset intractable epilepsy, delayed development, and movement disorder. De novo mutations and several hot spots in N34, G91, R126, R153, and R333 of exons 2, 3, 4, and 8 of SLC2A1 are associated with this condition. Seizures, one of the main clinical features of GLUT-1 deficiency, usually develop during infancy. Most patients experience brief and subtle myoclonic jerk and focal seizures that evolve into a mixture of different types of seizures, such as generalized tonic-clonic, absence, myoclonic, and complex partial seizures...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28012418/characterization-of-a-near-infrared-fluorescent-dcpo-tagged-glucose-analogue-for-cancer-cell-imaging
#17
Yanfen Fang, Wanli Zhang, Mengli Zhu, Shiguang Chen, Xuan Liu, Wei Lu, Xiongwen Zhang
Cancer cells are usually characterized with an increase in glucose uptake when compared with normal cells, which is known as Warburg effect. Near-infrared (NIR) fluorescent glucose analogues have been previously synthesized and been applied in cancer cell imaging. However, most NIR dyes usually have one or more charge in their structures, which may cause low cell membrane permeability and hamper their application in cell imaging. Here we reported a novel glucose analogue N2, which was designed and synthesized based on a new type of NIR dye, DCPO...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27997810/glut-1-dependent-glycolysis-is-increased-during-aging-related-lung-fibrosis-and-phloretin-inhibits-lung-fibrosis
#18
Soo Jung Cho, Jong-Seok Moon, Chang-Min Lee, Augustine M K Choi, Heather W Stout-Delgado
RATIONAL: Aging is associated with metabolic diseases such as type 2 diabetes mellitus, cardiovascular disease, cancer and neurodegeneration. Aging contributes to common processes including metabolic dysfunction, DNA damage and reactive oxygen species generation. While glycolysis has been linked to cell growth and proliferation, the mechanisms by which the activation of glycolysis by aging regulates fibrogenesis in lung remain unclear. OBJECTIVES: To determine if glucose transport 1 (GLUT1)-induced glycolysis regulates age-dependent fibrogenesis of the lung...
December 20, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27984051/brain-endothelial-dysfunction-following-pyrithiamine-induced-thiamine-deficiency-in-the-rat
#19
Sumit Sarkar, Serguei Liachenko, Merle G Paule, John Bowyer, Joseph P Hanig
Prolonged vitamin B1 (thiamine) deficiency can lead to neurological disorders such as Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome (WKS) in humans. These thiamine deficiency disorders have been attributed to vascular leakage, blood-brain barrier breakdown and neuronal loss in the diencephalon and brain stem. However, endothelial dysfunction following thiamine deficiency and its relationship to the phenomenon of neurodegeneration has not been clearly elucidated. The present study sought to begin to address this issue by evaluating vascular morphology and integrity in a pyrithiamine (PT)-induced rat model of thiamine deficiency...
October 28, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27981520/impact-of-pre-gestational-and-gestational-diabetes-mellitus-on-the-expression-of-glucose-transporters-glut-1-glut-4-and-glut-9-in-human-term-placenta
#20
Paweł Jan Stanirowski, Dariusz Szukiewicz, Michał Pyzlak, Nabil Abdalla, Włodzimierz Sawicki, Krzysztof Cendrowski
PURPOSE: Various studies in placental tissue suggest that diabetes mellitus alters the expression of glucose transporter (GLUT) proteins, with insulin therapy being a possible modulatory factor. The aim of the present study was quantitative evaluation of the expression of glucose transporters (GLUT-1, GLUT-4, GLUT-9) in the placenta of women in both, uncomplicated and diabetic pregnancy. Additionally, the effect of insulin therapy on the expression of selected glucose transporter isoforms was analyzed...
December 16, 2016: Endocrine
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