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https://www.readbyqxmd.com/read/28213682/mathematical-modelling-of-cytokines-mmps-and-fibronectin-fragments-in-osteoarthritic-cartilage
#1
Michelle Baker, Bindi S Brook, Markus R Owen
Osteoarthritis (OA) is a degenerative disease which causes pain and stiffness in joints. OA progresses through excessive degradation of joint cartilage, eventually leading to significant joint degeneration and loss of function. Cytokines, a group of cell signalling proteins, present in raised concentrations in OA joints, can be classified into pro-inflammatory and anti-inflammatory groups. They mediate cartilage degradation through several mechanisms, primarily the up-regulation of matrix metalloproteinases (MMPs), a group of collagen-degrading enzymes...
February 17, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28212250/economic-impact-of-nonmodifiable-risk-factors-in-orthopaedic-fracture-care-is-bundled-payment-feasible
#2
Siddharth A Mahure, Lorraine Hutzler, Richard S Yoon, Joseph A Bosco
OBJECTIVES: To determine whether bundled payments are feasible in the orthopaedic fracture setting, and the potential economic implications of this reimbursement structure. DESIGN: Prospective. SETTING: Multicenter. PATIENTS/PARTICIPANTS: Between 2004 and 2014, a total of 23,643 operatively treated patients with fracture and 544,067 patients with total joint arthroplasty (TJA) were identified using the New York State Statewide Planning and Research Cooperative System database...
March 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28211987/10-year-old-female-with-intragenic-kansl1-mutation-no-kansl1-related-intellectual-disability-and-preserved-verbal-intelligence
#3
Colleen Keen, Carole Samango-Sprouse, Holly Dubbs, Elaine H Zackai
Koolen-de Vries Syndrome (KdVS), also referred to as 17q21.31 microdeletion syndrome, is caused by haploinsufficiency of the KANSL1 gene. This genetic disorder is associated with a clinical phenotype including facial dysmorphism, developmental delay, and friendly disposition, as well as mild-to-moderate intellectual disability. We present the case of a 10 year 8 month old female with KdVS due to a de novo intragenic KANSL1 mutation. At this time, she does not present with intellectual disability, and her verbal intelligence is relatively preserved, although she has perceptual deficits, developmental dyspraxia, and severe speech disorder...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28210973/renal-drug-transporters-and-drug-interactions
#4
REVIEW
Anton Ivanyuk, Françoise Livio, Jérôme Biollaz, Thierry Buclin
Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug resistance protein (MRP) 2, MRP4, OATP1A2 and breast cancer resistance protein (BCRP) on the apical side. Organic cations are secreted by organic cation transporter (OCT) 2 on the basolateral side, and multidrug and toxic compound extrusion (MATE) proteins MATE1, MATE2/2-K, P-glycoprotein, organic cation and carnitine transporter (OCTN) 1 and OCTN2 on the apical side...
February 16, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28210361/estimating-the-cost-of-care-for-emergency-department-syncope-patients-comparison-of-three-models
#5
Marc A Probst, John K McConnell, Robert E Weiss, Amber L Laurie, Annick N Yagapen, Michelle P Lin, Jeffrey M Caterino, Manish N Shah, Benjamin C Sun
INTRODUCTION: We sought to compare three hospital cost-estimation models for patients undergoing evaluation for unexplained syncope using hospital cost data. Developing such a model would allow researchers to assess the value of novel clinical algorithms for syncope management. METHODS: We collected complete health services data, including disposition, testing, and length of stay (LOS), on 67 adult patients (age 60 years and older) who presented to the emergency department (ED) with syncope at a single hospital...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28210350/use-of-physician-in-triage-model-in-the-management-of-abdominal-pain-in-an-emergency-department-observation-unit
#6
John R Marshall, Robert Katzer, Shahram Lotfipour, Bharath Chakravarthy, Siri Shastry, Jessica Andrusaitis, Craig L Anderson, Erik D Barton
INTRODUCTION: Given the nationwide increase in emergency department (ED) visits it is of paramount importance for hospitals to find efficient ways to manage patient flow. The purpose of this study was to determine whether there is a significant difference in success rates, length of stay (LOS), and other demographic factors in two cohorts of patients admitted directly to an ED observation unit (EDOU) under an abdominal pain protocol by a physician in triage (bypassing the main ED) versus those admitted via the traditional pathway (evaluated and treated in the main ED prior to EDOU admission)...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28209637/the-impact-of-payer-source-on-trauma-outcomes-in-a-pediatric-population
#7
Felecia A Lee, Ashley M Hervey, Arash Sattarin, Aaron Deeds, Gina M Berg, Kimberly Molik
OBJECTIVES: Determine if there were differences in conclusions drawn regarding disparities in trauma outcomes based on literature-derived payer source definitions in a pediatric population. PATIENTS AND METHODS: Retrospective registry review of admitted pediatric trauma patients (≤17 years of age) at a level II pediatric trauma facility. Eligible patients were categorized into 3 payer source definitions: definition 1: commercially insured, Medicaid, uninsured; definition 2: insured, uninsured; definition 3: commercially insured, underinsured...
February 16, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28207968/mri-vs-ultrasound-as-the-initial-imaging-modality-for-pediatric-and-young-adult-patients-with-suspected-appendicitis
#8
Daniel Imler, Christine Keller, Shyam Sivasankar, Nancy Ewen Wang, Shreyas Vasanawala, Matias Bruzoni, James Quinn
BACKGROUND: While ultrasound (US), given its lack of ionizing radiation is currently the recommended initial imaging study of choice for the diagnosis of appendicitis in pediatric and young adult patients, it does have significant shortcomings. US is time intensive, operator dependent, and results in frequent inconclusive studies, thus necessitating further imaging, and admission for observation or repeat clinical visits. A rapid focused Magnetic Resonance Imaging (MRI) for appendicitis has been shown to have definitive sensitivity and specificity, similar to Computed tomography (CT) but without radiation and offers a potential alternative to US...
February 16, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28202187/male-factor-infertility-and-lack-of-openness-about-infertility-as-risk-factors-for-depressive-symptoms-in-males-undergoing-assisted-reproductive-technology-treatment%C3%A2-in-italy
#9
Alessandra Babore, Liborio Stuppia, Carmen Trumello, Carla Candelori, Ivana Antonucci
OBJECTIVE: To investigate the association between male factor infertility and openness to discussing assisted reproductive technology (ART) treatment with levels of depression among men undergoing infertility treatment. DESIGN: Cross-sectional. SETTING: Not applicable. PATIENT(S): Three hundred forty participants (170 men and their partners) undergoing ART treatments. INTERVENTION(S): Administration of a set of questionnaires...
February 12, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28199891/the-epidemiologic-characteristics-temporal-trends-predictors-of-death-and-discharge-disposition-in-patients-with-a-diagnosis-of-sepsis-a-cross-sectional-retrospective-cohort-study
#10
Sarah Elfeky, Pegah Golabi, Munkhzul Otgonsuren, Svetolik Djurkovic, Mary E Schmidt, Zobair M Younossi
PURPOSE: To assess recent epidemiologic characteristics, temporal trends, and predictors of death and discharge disposition in patients with sepsis. MATERIAL AND METHODS: This is a cross-sectional retrospective cohort study using the US National Inpatient Sample (NIS) data from 2009 to 2012. The study population included adults (18years and older) with sepsis-related International Classification of Diseases, Ninth Revision, Clinical Modification codes at the time of discharge...
January 20, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28199386/associations-of-lipid-profiles-with-insulin-resistance-and-%C3%AE-cell-function-in-adults-with-normal-glucose-tolerance-and-different-categories-of-impaired-glucose-regulation
#11
Shuang Zheng, Hua Xu, Huan Zhou, Xingxing Ren, Tingting Han, Yawen Chen, Huiying Qiu, Peihong Wu, Jun Zheng, Lihua Wang, Wei Liu, Yaomin Hu
AIMS: To investigate the associations of dyslipidemia with insulin resistance and β cell function in individuals with normal glucose tolerance (NGT) and different categories of impaired glucose regulation (IGR). METHODS: 544 subjects (365 with dyslipidemia and/or IGR and 179 with normal lipid and glucose tolerance) were enrolled in the study. All subjects underwent oral glucose tolerance test (OGTT). HOMA-IR was used to evaluate insulin sensitivity. Disposition index (DI) was used to evaluate β cell function...
2017: PloS One
https://www.readbyqxmd.com/read/28199149/a-genetic-method-to-evaluate-the-prevalence-of-unique-dna-profiles-between-sequential-ground-beef-batches
#12
G Peters, B Cleveland, J Higgins, F Butler, C Meghen
The delineation of ground beef batches has implications for the management of product disposition policies in the event of Shiga toxin-producing Escherichia coli contamination. Analysis of individual contributor animal-specific DNA profiles can provide valuable empirical data for understanding the dynamics of ground meat production processes and can act as a surrogate for cross-contamination. A genetic method was developed for characterizing the source raw material flow and carryover between discrete batches of ground beef in a large-scale commercial beef grinding operation...
February 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28197092/bci-control-of-heuristic-search-algorithms
#13
Marc Cavazza, Gabor Aranyi, Fred Charles
The ability to develop Brain-Computer Interfaces (BCI) to Intelligent Systems would offer new perspectives in terms of human supervision of complex Artificial Intelligence (AI) systems, as well as supporting new types of applications. In this article, we introduce a basic mechanism for the control of heuristic search through fNIRS-based BCI. The rationale is that heuristic search is not only a basic AI mechanism but also one still at the heart of many different AI systems. We investigate how users' mental disposition can be harnessed to influence the performance of heuristic search algorithm through a mechanism of precision-complexity exchange...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28194579/prediction-of-tissue-to-plasma-ratios-of-basic-compounds-in-mice
#14
Prashant B Nigade, Jayasagar Gundu, K Sreedhara Pai, Kumar V S Nemmani
BACKGROUND: Majority of reported studies so far developed correlation regression equations using the rat muscle-to-plasma drug concentration ratio (Kp-muscle) to predict tissue-to-plasma drug concentration ratios (Kp-tissues). Use of regression equations derived from rat Kp-muscle may not be ideal to predict the mice tissue-Kps as there are species differences. OBJECTIVES: (i) To develop the linear regression equations using mouse tissue-Kps; (ii) to assess the correlation between organ blood flow and/or organ weight with tissue-Kps and (iii) compare the observed tissue-Kps from mice with corresponding predicted tissue-Kps using Richter's rat-Kp specific equations...
February 13, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28191803/population-pharmacokinetics-of-imatinib-and-its-application-to-the-therapeutic-drug-monitoring-middle-east-cml-population
#15
Mehdi Ansari, Behjat Kalantary-Khandani, Abbas Pardakhty, Moein Safavi, Nabi Mosavi, Ehsan Mohajeri
INTRODUCTION: Despite the outstanding results generally obtained with Imatinib in the treatment of chronic myeloid leukemia, some patients show sub-optimal or no response. To evaluate the relationship between steady-state through plasma concentration and clinical response in CML patients. The objectives of this study were to assess the variability in Imatinib pharmacokinetics and to explore the effects of several demographic and biological covariates on the disposition of Imatinib. METHODS: A population pharmacokinetic analysis was performed on 170 plasma samples from 74 adult Iranian chronic myeloid leukemia patients...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191653/generalized-hostile-interpretation-bias-regarding-facial-expressions-characteristic-of-pathological-aggressive-behavior
#16
Danique Smeijers, Mike Rinck, Erik Bulten, Thom van den Heuvel, Robbert-Jan Verkes
Individuals with aggression regulation disorders tend to attribute hostility to others in socially ambiguous situations. Previous research suggests that this "hostile attribution bias" is a powerful cause of aggression. Facial expressions form important cues in the appreciation of others' intentions. Furthermore, accurate processing of facial expressions is fundamental to normal socialization. However, research on interpretation biases in facial affect is limited. It is asserted that a hostile interpretation bias (HIB) is likely to be displayed by individuals with an antisocial (ASPD) and borderline personality disorder (BPD) and probably also with an intermittent explosive disorder (IED)...
February 12, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28191569/benzimidazolylquinoxalines-novel-fluorophores-with-tuneable-sensitivity-to-solvent-effects
#17
Timur I Burganov, Nataliya A Zhukova, Vakhid A Mamedov, Christoph Bannwarth, Stefan Grimme, Sergey A Katsyuba
We report on the photophysical properties, conjugation, conformational behavior, intra- and intermolecular hydrogen bonds (HBs) of a series of novel fluorophores, consisting of 3-arylquinoxaline and benzimidazole moieties linked by a single CC bond. Computations employing density functional theory (DFT) reveal that conjugation between these moieties stabilizes syn-conformers with two HB centers located on the same side of the molecule. Anti-conformers form stronger intermolecular HBs with DMSO and DMF than syn-conformers, and this influences the energy gap between syn- and anti-forms, especially upon excitation of the molecules to the S1 state...
February 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28188866/does-a-future-oriented-temporal-perspective-relate-to-body-mass-index-eating-and-exercise-a-meta-analysis
#18
Allison M Sweeney, Ileana Culcea
OBJECTIVE: The present study aimed to quantify the magnitude of the association between future temporal perspective and Body Mass Index (BMI), diet, and exercise, respectively, and to clarify whether subjective future-focus scales or delay-discounting tasks are a more robust predictor of health behaviors. METHODS: A systematic search was conducted for studies that included a dispositional measure of future temporal perspective and a measure of BMI, eating, and/or exercise behavior...
February 7, 2017: Appetite
https://www.readbyqxmd.com/read/28188857/sensitivity-to-carbon-dioxide-and-translational-studies-of-anxiety-disorders
#19
Marco Battaglia
Heightened concentrations of CO2 in inhaled air provoke temporary acidification of the brain, followed by compensatory hyperventilation and increased arousal/anxiety. These responses are likely to map a basic, latent general alarm/avoidance system that is largely shared across mammals, and are sources of individual differences. By showing paroxysmal respiratory and emotional responses to CO2 challenges, humans with panic and separation anxiety disorders lie at one extreme of the distribution for CO2 sensitivity...
February 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28188298/comparison-between-radioanalysis-and-19-f-nuclear-magnetic-resonance-spectroscopy-in-the-determination-of-mass-balance-metabolism-and-distribution-of-pefloxacin
#20
Haitao Hu, Kishore Kumar Katyayan, Boris A Czeskis, Everett J Perkins, Palaniappan Kulanthaivel
Mass balance and metabolism studies using radiolabeled substances are well recognized as an important part of the drug development process. Herein, we directly assessed the use of (19)F NMR to achieve quantitative mass balance, metabolism and distribution information for fluorinated compounds without the need for radiolabeled synthesis/study. As a test case, the disposition of pefloxacin, a fluoroquinolone antibiotic, was evaluated in rats using quantitative (19)F NMR in parallel with a radiolabeled study. Urine, bile, and feces samples were collected over specific periods following oral administration of either 25 mg/kg [(14)C]pefloxacin or 25 mg/kg pefloxacin and were subsequently profiled by radioactivity or (19)F NMR, respectively...
February 10, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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