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https://www.readbyqxmd.com/read/28077845/when-words-were-wanted-but-woefully-wanting-we-waged-war-with-chess
#1
Burton Norman Seitler
What do you say to a child who rarely speaks? How do you work with such a youngster? What are the sine qua nons or guiding principles upon which analysts can draw? And, how do we know if we are being helpful? Sam was 9-years when I began treating him. He was extremely withdrawn and rarely spoke more than a few words. Instead, he mainly played chess. I did not know at first whether Sam's taciturn demeanor was due to shyness, limited verbal abilities, or the stultifying effects of trauma. Fortuitously, during one of many seemingly "innocent" games of chess, Sam happened to make a bold move, to which I admiringly remarked, "What a move, you're killing me...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28073068/comparative-analysis-of-isotropic-diffusion-weighted-imaging-sequences
#2
Sebastian Vellmer, Rüdiger Stirnberg, Daniel Edelhoff, Dieter Suter, Tony Stöcker, Ivan I Maximov
Visualisation of living tissue structure and function is a challenging problem of modern imaging techniques. Diffusion MRI allows one to probe in vivo structures on a micrometer scale. However, conventional diffusion measurements are time-consuming procedures, because they require several measurements with different gradient directions. Considerable time savings are therefore possible by measurement schemes that generate an isotropic diffusion weighting in a single shot. Multiple approaches for generating isotropic diffusion weighting are known and have become very popular as useful tools in clinical research...
December 30, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28072839/assessment-of-attention-deficits-in-adolescent-offspring-exposed-to-maternal-type-1-diabetes
#3
Birgitte Bytoft, Sine Knorr, Zuzana Vlachova, Rikke B Jensen, Elisabeth R Mathiesen, Henning Beck-Nielsen, Claus H Gravholt, Dorte M Jensen, Tine D Clausen, Erik L Mortensen, Peter Damm
OBJECTIVE: The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring. RESEARCH DESIGN AND METHODS: Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style...
2017: PloS One
https://www.readbyqxmd.com/read/28065485/systemic-sclerosis-sine-scleroderma-in-mexican-patients-case-reports
#4
Olga Vera-Lastra, Christian Alexis Sauceda-Casas, María Del Pilar Cruz Domínguez, Sergio Alberto Mendoza Alvarez, Jesús Sepulceda-Delgado
: Systemic sclerosis sine scleroderma (ssSSc) is a form of systemic sclerosis that is characterized by Raynaud's phenomenon (RP), visceral involvement without thickening of skin and anticentromere antibodies (ACA). We studied 10 ssSsc patients with a prevalence of 2%. The clinical signs were: RP 9/10, esophageal manifestations 8/10, pulmonary arterial hypertension 4/10, interstitial lung disease 4/10, cardiac signs 3/10 and ACA 8/10. CONCLUSION: In patients with RP, esophageal dysmotility, interstitial lung disease and pulmonary arterial hypertension should be tested for ACA in order to establish a prompt diagnosis and treatment of ssSSc...
January 3, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28062442/sine_scan-an-efficient-tool-to-discover-short-interspersed-nuclear-elements-sines-in-large-scale-genomic-datasets
#5
Hongliang Mao, Hao Wang
MOTIVATION: Short Interspersed Nuclear Elements (SINEs) are transposable elements (TEs) that amplify through a copy-and-paste mode via RNA intermediates. The computational identification of new SINEs are challenging because of their weak structural signals and rapid diversification in sequences. RESULTS: Here we report SINE_Scan, a highly efficient program to predict SINE elements in genomic DNA sequences. SINE_Scan integrates hallmark of SINE transposition, copy number and structural signals to identify a SINE element...
January 6, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28060384/effects-of-functional-endoscopic-sinus-surgery-on-the-acoustics-of-the-sinonasal-tract
#6
M Havel, S Becker, M Schuster, T Johnson, A Maier, J Sundberg
BACKGROUND: Nasal and paranasal cavities are supposed to contribute substantially to the vocal tract resonator properties. However, their acoustical effects as well as the effects of sinus surgery on the voice remain unclear. In this work we investigate resonance phenomena of paranasal sinuses prior to and after various rhinosurgical procedures in cadaveric human sinonasal tracts and corresponding 3D casts. METHODOLOGY: Nasal and paranasal cavities of formalin-preserved cadavers and corresponding 3D replicas were excited by sine-tone sweeps from an earphone placed in the epipharynx...
January 6, 2017: Rhinology
https://www.readbyqxmd.com/read/28059849/is-age-an-important-factor-for-vascular-response-to-statin-therapy-a-serial-optical-coherence-tomography-and-intravascular-ultrasound-study
#7
Jiannan Dai, Jingbo Hou, Lei Xing, Haibo Jia, Sining Hu, Tsunenari Soeda, Yoshiyasu Minami, Daniel Ong, Rocco Vergallo, Shaosong Zhang, Hang Lee, Bo Yu, Ik-Kyung Jang
OBJECTIVE: Age-related structural and functional changes in vessel wall may affect the time course of vascular response to statin therapy. In this study, we sought to compare the response of lipid-rich plaque to statin therapy in elderly versus younger patients using optical coherence tomography and intravascular ultrasound. PATIENTS AND METHODS: Sixty-nine patients who underwent serial optical coherence tomography and intravascular ultrasound at the time point of baseline, 6, and 12 months were divided into two groups according to median age: group A (age<57 years, n=35) and group B (age≥57 years, n=34)...
January 4, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28059359/fundamental-and-practical-limits-of-planar-tracking-solar-concentrators
#8
Alex J Grede, Jared S Price, Noel C Giebink
Planar microtracking provides an alternate paradigm for solar concentration that offers the possibility of realizing high-efficiency embedded concentrating photovoltaic systems in the form factor of standard photovoltaic panels. Here, we investigate the thermodynamic limit of planar tracking optical concentrators and establish that they can, in principal, achieve the sine limit of their orientationally-tracked counterparts provided that the receiver translates a minimum distance set by the field of view half-angle...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28058053/survival-regression-modeling-strategies-in-cvd-prediction
#9
Mahnaz Barkhordari, Mojgan Padyab, Mahsa Sardarinia, Farzad Hadaegh, Fereidoun Azizi, Mohammadreza Bozorgmanesh
BACKGROUND: A fundamental part of prevention is prediction. Potential predictors are the sine qua non of prediction models. However, whether incorporating novel predictors to prediction models could be directly translated to added predictive value remains an area of dispute. The difference between the predictive power of a predictive model with (enhanced model) and without (baseline model) a certain predictor is generally regarded as an indicator of the predictive value added by that predictor...
April 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28051830/gambling-and-the-need-for-new-responses-in-public-health-with-an-addiction-sine-substantia
#10
M Crusco, F Massoni, E Luzi, P Ricci, M Pelosi, P Corbosiero, M Rapp-Ricciardi, S Ricci
BACKGROUND: The Gambling Disorder (GD) was recently defined as a behavioral addiction by the "The Diagnostic and Statistical Manual of Mental Disorders IV"( DSM-V) since the clinical, neurobiological and psychopathological similarities led it to be defined it as an addiction "sine substantia". The aim of this study is to formulate an "identikit" of the gambler, to evaluate a possible association between GD / emotional specific factors and the correlation between GD / substance abuse, GD / suicide...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28049706/coordination-of-cell-cycle-progression-and-mitotic-spindle-assembly-involves-histone-h3-lysine-4-methylation-by-set1-compass
#11
Traude H Beilharz, Paul F Harrison, Douglas Maya Miles, Michael Ming See, Uyen Minh Merry Le, Ming Kalanon, Melissa Jane Curtis, Qambar Hasan, Julie Saksouk, Thanasis Margaritis, Frank Holstege, Vincent Geli, Bernhard Dichtl
Methylation of histone H3 lysine 4 (H3K4) by Set1 complex/COMPASS is a hallmark of eukaryotic chromatin, but it remains poorly understood how this post-translational modification contributes to the regulation of biological processes like the cell cycle. Here, we report a H3K4 methylation-dependent pathway in Saccharomyces cerevisiae that governs toxicity toward benomyl, a microtubule destabilizing drug. Benomyl-sensitive growth of wild-type cells required mono- and dimethylation of H3K4 and Pho23, a PHD-containing subunit of the Rpd3L complex...
January 2017: Genetics
https://www.readbyqxmd.com/read/28048014/su-f-t-255-accuracy-and-precision-of-dynamic-tracking-irradiation-with-vero-4drt-system
#12
N Hayashi, Y Takada, T Mizuno, H Nakae, T Murai
PURPOSE: The VERO-4DRT system is able to provide dynamic tracking irradiation (DTI) for the target with respiratory motion. This technique requires enough commissioning for clinical implementation. The purpose of this study is to make sure the accuracy and precision of DTI using VERO- 4DRT through commissioning from fundamental evaluation to end-to-end test. METHOD: We evaluated several contents for DTI commissioning: the accuracy of absorption dose at isocenter in DTI, the field size and penumbra of DTI, the accuracy of 4D modeling in DTI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046661/su-f-t-208-an-efficient-planning-approach-to-posterior-fossa-tumor-bed-boosts-using-proton-pencil-beam-scanning-in-fixed-beam-room
#13
N Ju, C Chen, S Gans, E Hug, O Cahlon, S Wolden, B Chon, B Yeh, H Tsai, K Sine, D Mah
PURPOSE: A fixed-beam room could be underutilized in a multi-room proton center. We investigated the use of proton pencil beam scanning (PBS) on a fixed-beam as an alternative for posterior fossa tumor bed (PF-TB) boost treatments which were usually treating on a gantry with uniform scanning. METHODS: Five patients were treated with craniospinal irradiation (CSI, 23.4 or 36.0 Gy(RBE)) followed by a PF-TB boost to 54 Gy(RBE) with proton beams. Three PF-TB boost plans were generated for each patient: (1) a uniform scanning (US) gantry plan with 4-7 posterior fields shaped with apertures and compensators (2) a PBS plan using bi-lateral and vertex fields with a 3-mm planning organ-at-risk volume (PRV) expansion around the brainstem and (3) PBS fields using same beam arrangement but replacing the PRV with robust optimization considering a 3-mm setup uncertainty...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046262/we-de-bra-11-a-study-of-motion-tracking-accuracy-of-robotic-radiosurgery-using-a-novel-ccd-camera-based-end-to-end-test-system
#14
L Wang, B Nelson, Y M Yang
PURPOSE: A novel end-to-end test system using a CCD camera and a scintillator based phantom (XRV-124, Logos Systems Int'l) capable of measuring the beam-by-beam delivery accuracy of Robotic Radiosurgery (CyberKnife) was developed and reported in our previous work. This work investigates its application in assessing the motion tracking (Synchrony) accuracy for CyberKnife. METHODS: A QA plan with Anterior and Lateral beams (with 4 different collimator sizes) was created (Multiplan v5...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28036037/multi-objective-sliding-mode-control-on-vehicle-cornering-stability-with-variable-gear-ratio-actuator-based-active-front-steering-systems
#15
Xinbo Ma, Pak Kin Wong, Jing Zhao, Zhengchao Xie
Active front steering (AFS) is an emerging technology to improve the vehicle cornering stability by introducing an additional small steering angle to the driver's input. This paper proposes an AFS system with a variable gear ratio steering (VGRS) actuator which is controlled by using the sliding mode control (SMC) strategy to improve the cornering stability of vehicles. In the design of an AFS system, different sensors are considered to measure the vehicle state, and the mechanism of the AFS system is also modelled in detail...
December 28, 2016: Sensors
https://www.readbyqxmd.com/read/28031459/%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-relationships-between-subunit-stoichiometry-and-function-at-the-single-channel-level
#16
Simone Mazzaferro, Isabel Bermudez, Steven M Sine
Acetylcholine receptors (AChRs) comprised of α4 and β2 subunits are the most abundant class of nicotinic AChR in the brain. They contribute to cognition, reward, mood and nociception, and are implicated in a range of neurological disorders. Previous measurements of whole-cell macroscopic currents showed that α4 and β2 subunits assemble in two predominant pentameric stoichiometries, which differ in their sensitivity to agonists, antagonists and allosteric modulators. Here we compare agonist-elicited single channel currents from receptors assembled with an excess of either the α4 or β2 subunit, forming receptor populations biased toward one or the other stoichiometry, with currents from receptors composed of five concatemeric subunits in which the subunit stoichiometry is predetermined...
December 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28028040/whole-genome-expression-analysis-of-mammalian-wide-interspersed-repeat-elements-in-human-cell-lines
#17
Davide Carnevali, Anastasia Conti, Matteo Pellegrini, Giorgio Dieci
With more than 500,000 copies, mammalian-wide interspersed repeats (MIRs), a sub-group of SINEs, represent ∼2.5% of the human genome and one of the most numerous family of potential targets for the RNA polymerase (Pol) III transcription machinery. Since MIR elements ceased to amplify ∼130 myr ago, previous studies primarily focused on their genomic impact, while the issue of their expression has not been extensively addressed. We applied a dedicated bioinformatic pipeline to ENCODE RNA-Seq datasets of seven human cell lines and, for the first time, we were able to define the Pol III-driven MIR transcriptome at single-locus resolution...
December 27, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28018798/exact-solutions-for-unsteady-free-convection-flow-over-an-oscillating-plate-due-to-non-coaxial-rotation
#18
Ahmad Qushairi Mohamad, Ilyas Khan, Zulkhibri Ismail, Sharidan Shafie
BACKGROUND: Non-coaxial rotation has wide applications in engineering devices, e.g. in food processing such as mixer machines and stirrers with a two-axis kneader, in cooling turbine blades, jet engines, pumps and vacuum cleaners, in designing thermal syphon tubes, and in geophysical flows. Therefore, this study aims to investigate unsteady free convection flow of viscous fluid due to non-coaxial rotation and fluid at infinity over an oscillating vertical plate with constant wall temperature...
2016: SpringerPlus
https://www.readbyqxmd.com/read/28018641/binocular-combination-of-stimulus-orientation
#19
O Yehezkel, J Ding, A Sterkin, U Polat, D M Levi
When two sine waves that differ slightly in orientation are presented to the two eyes separately, a single cyclopean sine wave is perceived. However, it is unclear how the brain calculates its orientation. Here, we used a signal detection rating method to estimate the perceived orientation when the two eyes were presented with Gabor patches that differed in both orientation and contrast. We found a nearly linear combination of orientation when both targets had the same contrast. However, the binocular percept shifted away from the linear prediction towards the orientation with the higher contrast, depending on both the base contrast and the contrast ratio...
November 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/28017541/production-of-flavor-compounds-from-olive-mill-waste-by-rhizopus-oryzae-and-candida-tropicalis
#20
Onur Guneser, Asli Demirkol, Yonca Karagul Yuceer, Sine Ozmen Togay, Muge Isleten Hosoglu, Murat Elibol
The purpose of this study was to investigate the production of flavor compounds from olive mill waste by microbial fermentation of Rhizopus oryzae and Candida tropicalis. Olive mill waste fermentations were performed in shake and bioreactor cultures. Production of flavor compounds from olive mill waste was followed by Gas Chromatography-Mass spectrometry, Gas chromatography- olfactometry and Spectrum Sensory Analysis(®). As a result, 1.73-log and 3.23-log cfu/mL increases were observed in the microbial populations of R...
November 23, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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