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https://www.readbyqxmd.com/read/28429632/comparison-of-piezoresistive-sensor-to-picopress%C3%A2-in-in-vitro-interface-pressure-measurement
#1
Yung-Wei Chi, Kuo-Hao Tseng, Ruya Li, Tingrui Pan
Objective Interface pressure, the sine qua non for compression therapy, is rarely measured in clinical practice and scientific research. The goal of this study aimed to compare and examine the accuracy between a commercially available piezoresistive sensor and PicoPress® (Microlab, Padua, Italy) using the cylinder cuff model to measure in-vitro interface pressure. Method Ten piezoresistive sensors were calibrated using the National Institute of Standard and Technology certified manometer, and compared to PicoPress® using cylinder cuff model from 20 to 120 mmHg...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28429069/mupexi-prediction-of-neo-epitopes-from-tumor-sequencing-data
#2
Anne-Mette Bjerregaard, Morten Nielsen, Sine Reker Hadrup, Zoltan Szallasi, Aron Charles Eklund
Personalization of immunotherapies such as cancer vaccines and adoptive T cell therapy depends on identification of patient-specific neo-epitopes that can be specifically targeted. MuPeXI, the mutant peptide extractor and informer, is a program to identify tumor-specific peptides and assess their potential to be neo-epitopes. The program input is a file with somatic mutation calls, a list of HLA types, and optionally a gene expression profile. The output is a table with all tumor-specific peptides derived from nucleotide substitutions, insertions, and deletions, along with comprehensive annotation, including HLA binding and similarity to normal peptides...
April 20, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28423678/influence-of-ipilimumab-on-expanded-tumour-derived-t-cells-from-patients-with-metastatic-melanoma
#3
Jon Bjoern, Rikke Lyngaa, Rikke Andersen, Lisbet Hölmich Rosenkrantz, Sine Reker Hadrup, Marco Donia, Inge Marie Svane
INTRODUCTION: Tumour infiltrating lymphocyte (TIL) based adoptive cell therapy (ACT) is a promising treatment for patients with advanced melanoma. Retrospective studies suggested an association between previous treatment with anti-CTLA-4 antibodies and long term survival after subsequent ACT. Thus, we hypothesized that treatment with anti-CTLA-4 antibodies can induce favourable changes to be detected in TILs. RESULTS: Expanded T cells from Ipilimumab treated patients had a higher proportion of cells expressing CD27, intracellular CTLA-4, TIM-3 and LAG-3...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422999/zooming-in-from-spatially-extended-traveling-waves-to-localized-structures-the-case-of-the-sine-gordon-equation-in-1-3-dimensions
#4
Yair Zarmi
The Sine-Gordon equation in (1+3) dimensions has N-traveling front ("kink", "domain wall")- solutions for all N ≥ 1. A nonlinear functional of the solution, which vanishes on a single-front, maps multi-front solutions onto sets of infinitely long, but laterally bounded, rods, which move in space. Each rod is localized in the vicinity of the intersection of two Sine-Gordon fronts. The rod systems are solutions of the linear wave equation, driven by a term that is constructed out of Sine-Gordon fronts. An additional linear operation maps multi-rod systems onto sets of blobs...
2017: PloS One
https://www.readbyqxmd.com/read/28415370/bubblelike-structures-generated-by-activation-of-internal-shape-modes-in-two-dimensional-sine-gordon-line-solitons
#5
Mónica A García-Ñustes, Juan F Marín, Jorge A González
Nonlinear waves that collide with localized defects exhibit complex behavior. Apart from reflection, transmission, and annihilation of an incident wave, a local inhomogeneity can activate internal modes of solitons, producing many impressive phenomena. In this work we investigate a two-dimensional sine-Gordon model perturbed by a family of localized forces. We observed the formation of bubblelike and droplike structures due to local internal shape mode instabilities. We describe the formation of such structures on the basis of a one-dimensional theory of activation of internal modes of sine-Gordon solitons...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28413449/links-between-dna-methylation-and-nucleosome-occupancy-in-the-human-genome
#6
Clayton K Collings, John N Anderson
BACKGROUND: DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator of high nucleosome occupancy has not been settled. For example, the methylation levels of DNA flanking CTCF sites are higher in linker DNA than in nucleosomal DNA, while other studies have shown that the nucleosome core is the preferred site of methylation. In this study, we make progress toward understanding these conflicting phenomena by implementing a bioinformatics approach that combines MNase-seq and NOMe-seq data and by comprehensively profiling DNA methylation and nucleosome occupancy throughout the human genome...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28408613/air-pollution-and-the-incidence-of-ischaemic-and-haemorrhagic-stroke-in-the-south-london-stroke-register-a-case-cross-over-analysis
#7
B K Butland, R W Atkinson, S Crichton, B Barratt, S Beevers, A Spiridou, U Hoang, F J Kelly, C D Wolfe
BACKGROUND: Few European studies investigating associations between short-term exposure to air pollution and incident stroke have considered stroke subtypes. Using information from the South London Stroke Register for 2005-2012, we investigated associations between daily concentrations of gaseous and particulate air pollutants and incident stroke subtypes in an ethnically diverse area of London, UK. METHODS: Modelled daily pollutant concentrations based on a combination of measurements and dispersion modelling were linked at postcode level to incident stroke events stratified by haemorrhagic and ischaemic subtypes...
April 13, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28405789/left-ventricular-strain-and-twisting-in-heart-failure-with-preserved-ejection-fraction-an-updated-review
#8
REVIEW
Marijana Tadic, Elisabeth Pieske-Kraigher, Cesare Cuspidi, Martin Genger, Daniel A Morris, Kun Zhang, Nina Alexandra Walther, Burket Pieske
Despite the high prevalence of the patients with heart failure with preserved ejection fraction (HFpEF), our knowledge about this entity, from diagnostic tools to therapeutic approach, is still not well established. The evaluation of patients with HFpEF is mainly based on echocardiography, as the most widely accepted tool in cardiac imaging. Identification of left ventricular (LV) diastolic dysfunction has long been considered as the only responsible for HFpEF, and its evaluation is still "sine qua non" of HFpEF diagnostics...
April 12, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28404965/impact-of-statins-therapy-on-morphological-changes-in-lipid-rich-plaques-stratified-by-10-year-framingham-risk-score-a-serial-optical-coherence-tomography-study
#9
Yinchun Zhu, Lin Lin, Chao Wang, Haibo Jia, Sining Hu, Lulu Li, Xiling Zhang, Gonghui Zheng, Yan Wang, Rong Sun, Abigail Afolabi, Irina Mustafina, Jingbo Hou, Shaosong Zhang, Bo Yu
The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52)...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28398974/future-needs-for-nursing-talent-in-scandinavian-countries-a-systematic-review-protocol
#10
Randi K Jakobsen, Sine M Herholdt-Lomholdt
The aim of this review is to systematically identify, appraise and synthesize available text and opinion papers from policy-makers and trade unions in Scandinavian countries (Denmark, Sweden and Norway) containing information about nursing talent needed in healthcare systems for the future. The overall objective is to identify and synthesize the opinions of various stakeholders of what they believe is required in terms of nursing talent in Scandinavia.In this review, "nursing talent" refers to certain skills or competencies that are essential within nursing to meet the challenges and demands of future health care...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28396964/space-time-analysis-of-gravitropism-in-etiolated-arabidopsis-hypocotyls-using-bioluminescence-imaging-of-the-iaa19-promoter-fusion-with-a-destabilized-luciferase-reporter
#11
Kotaro T Yamamoto, Masaaki K Watahiki, Jun Matsuzaki, Soichirou Satoh, Hisayo Shimizu
Imaging analysis was carried out during the gravitropic response of etiolated Arabidopsis hypocotyls, using an IAA19 promoter fusion of destabilized luciferase as a probe. From the bright-field images we obtained the local deflection angle to the vertical, A, local curvature, C, and the partial derivative of C with respect to time, [Formula: see text]. These were determined every 19.9 µm along the curvilinear length of the hypocotyl, at ~10 min intervals over a period of ~6 h after turning hypocotyls through 90° to the horizontal...
April 10, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28395319/speech-rate-normalization-and-phonemic-boundary-perception-in-cochlear-implant-users
#12
Brittany N Jaekel, Rochelle S Newman, Matthew J Goupell
Purpose: Normal-hearing (NH) listeners rate normalize, temporarily remapping phonemic category boundaries to account for a talker's speech rate. It is unknown if adults who use auditory prostheses called cochlear implants (CI) can rate normalize, as CIs transmit degraded speech signals to the auditory nerve. Ineffective adjustment to rate information could explain some of the variability in this population's speech perception outcomes. Method: Phonemes with manipulated voice-onset-time (VOT) durations were embedded in sentences with different speech rates...
April 10, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28391141/development-and-validation-of-a-novel-multiplexed-dna-analysis-system-innotyper-%C3%A2-21
#13
Hiromi Brown, Robyn Thompson, Gina Murphy, Dixie Peters, Bobby La Rue, Jonathan King, Anne H Montgomery, Marion Carroll, James Baus, Sid Sinha, Frank R Wendt, Bing Song, Ranajit Chakraborty, Bruce Budowle, Sudhir K Sinha
We report here a novel multiplexed DNA analysis system consisting of 20 Alu markers and Amelogenin for analysis of highly degraded forensic biological samples. The key to the success of the system in obtaining results from degraded samples is the primer design yielding small amplicon size (60-125bp) for all 20 markers. The markers included in the InnoTyper(®) 21 system are bi-allelic, having two possible allelic states (insertion or null) and thus termed INNULs. The markers are short interspersed nuclear elements (SINEs), a category of retrotransposable elements (REs) which are non-coding genomic DNA repeat sequences, or "mobile insertion elements," comprising approximately 40% of the human genome...
March 18, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28388884/inhibition-of-six1-affects-tumour-invasion-and-the-expression-of-cancer-stem-cell-markers-in-pancreatic-cancer
#14
Tristan Lerbs, Savita Bisht, Sebastian Schölch, Mathieu Pecqueux, Glen Kristiansen, Martin Schneider, Bianca T Hofmann, Thilo Welsch, Christoph Reissfelder, Nuh N Rahbari, Johannes Fritzmann, Peter Brossart, Jürgen Weitz, Georg Feldmann, Christoph Kahlert
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression and metastasis. Assessment of transcription factors involved in these two mechanisms can help to identify new targets for an oncological therapy. In this study, we focused on the evaluation of the transcription factor Six1 (Sine oculis 1). This protein is involved in embryologic development and its contribution to carcinogenesis has been described in several studies. METHODS: Immunohistochemistry against Six1 was performed on a tissue microarray containing specimens of primary pancreatic ductal adenocarcinomas (PDAC) of 139 patients...
April 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28368037/high-resolution-rna-allelotyping-along-the-inactive-x-chromosome-evidence-of-rna-polymerase-iii-in-regulating-chromatin-configuration
#15
Ru Hong, Bingqing Lin, Xinyi Lu, Lan-Tian Lai, Xin Chen, Amartya Sanyal, Huck-Hui Ng, Kun Zhang, Li-Feng Zhang
We carried out padlock capture, a high-resolution RNA allelotyping method, to study X chromosome inactivation (XCI). We examined the gene reactivation pattern along the inactive X (Xi), after Xist (X-inactive specific transcript), a prototype long non-coding RNA essential for establishing X chromosome inactivation (XCI) in early embryos, is conditionally deleted from Xi in somatic cells (Xi(∆Xist)). We also monitored the behaviors of X-linked non-coding transcripts before and after XCI. In each mutant cell line, gene reactivation occurs to ~6% genes along Xi(∆Xist) in a recognizable pattern...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28367243/sine-oculis-homeobox-homolog-1-regulates-mitochondrial-apoptosis-pathway-via-caspase-7-in-gastric-cancer-cells
#16
Peizhun Du, Jing Zhao, Jing Wang, Yongchao Liu, Hong Ren, Rajan Patel, Cheng'en Hu, Wenhong Zhang, Guangjian Huang
Sine oculis homeobox homolog 1 (Six1) is crucial in normal organ development. Recently, Six1 is reported to display aberrant expression in various cancers and plays important roles in cancer development. However, the regulatory mechanism of Six1 in gastric cancer is largely unknown. In the current study, we found that Six1 was increased in gastric cancer tissues, and its upregulation significantly associated with lymph node metastasis (p=0.042) and poor differentiation (p=0.039). Next, we took advantage of public available microarray data to assess Six1 prognostic value with online K-M Plotter software in gastric cancer, which demonstrated that patients with higher Six1 expression had shorter survival time (p=0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28362674/human-frequency-following-responses-to-vocoded-speech
#17
Saradha Ananthakrishnan, Xin Luo, Ananthanarayan Krishnan
OBJECTIVES: Vocoders offer an effective platform to simulate the effects of cochlear implant speech processing strategies in normal-hearing listeners. Several behavioral studies have examined the effects of varying spectral and temporal cues on vocoded speech perception; however, little is known about the neural indices of vocoded speech perception. Here, the scalp-recorded frequency following response (FFR) was used to study the effects of varying spectral and temporal cues on brainstem neural representation of specific acoustic cues, the temporal envelope periodicity related to fundamental frequency (F0) and temporal fine structure (TFS) related to formant and formant-related frequencies, as reflected in the phase-locked neural activity in response to vocoded speech...
March 30, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28356123/epidemiology-of-chronic-obstructive-pulmonary-disease-in-the-global-hiv-infected-population-a-systematic-review-and-meta-analysis-protocol
#18
Jean Joel R Bigna, Angeladine Malaha Kenne, Serra Lem Asangbeh
BACKGROUND: Evidence suggests a relationship between human immunodeficiency virus (HIV) infection and chronic obstructive pulmonary disease (COPD). Although the high burden of COPD and the HIV disease is clearly demonstrated, to the best of our knowledge, there is a lack of summary and meta-analysis data on the epidemiology of COPD in the global HIV-infected population to date. The present protocol for a systematic review and meta-analysis intends to summarize existing data on the prevalence, incidence, and risk factors of COPD in the global HIV-infected population...
March 29, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28355180/dhx9-suppresses-rna-processing-defects-originating-from-the-alu-invasion-of-the-human-genome
#19
Tuğçe Aktaş, İbrahim Avşar Ilık, Daniel Maticzka, Vivek Bhardwaj, Cecilia Pessoa Rodrigues, Gerhard Mittler, Thomas Manke, Rolf Backofen, Asifa Akhtar
Transposable elements are viewed as 'selfish genetic elements', yet they contribute to gene regulation and genome evolution in diverse ways. More than half of the human genome consists of transposable elements. Alu elements belong to the short interspersed nuclear element (SINE) family of repetitive elements, and with over 1 million insertions they make up more than 10% of the human genome. Despite their abundance and the potential evolutionary advantages they confer, Alu elements can be mutagenic to the host as they can act as splice acceptors, inhibit translation of mRNAs and cause genomic instability...
April 6, 2017: Nature
https://www.readbyqxmd.com/read/28348165/combinatorial-dna-methylation-codes-at-repetitive-elements
#20
Christophe Papin, Abdulkhaleg Ibrahim, Stephanie Le Gras, Amandine Velt, Bernard Jost, Isabelle Stoll, Hervé Menoni, Christian Bronner, Stefan Dimitrov, Ali Hamiche
DNA methylation is an essential epigenetic modification, present in both unique DNA sequences and repetitive elements, but its exact function in repetitive elements remains obscure. Here, we describe the genome-wide comparative analysis of the 5mC, 5hmC, 5fC and 5caC profiles of repetitive elements in mouse embryonic fibroblasts and mouse embryonic stem cells. We provide evidence for distinct and highly specific DNA methylation/oxidation patterns of the repetitive elements in both cell types, which mainly affect CA repeats and evolutionary conserved mouse-specific transposable elements including IAP-LTRs, SINEs B1m/B2m and L1Md-LINEs...
March 27, 2017: Genome Research
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