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https://www.readbyqxmd.com/read/27930646/retinal-expression-of-the-drosophila-eyes-absent-gene-is-controlled-by-several-cooperatively-acting-cis-regulatory-elements
#1
Bonnie M Weasner, Brandon P Weasner, Sarah D Neuman, Arash Bashirullah, Justin P Kumar
The eyes absent (eya) gene of the fruit fly, Drosophila melanogaster, is a member of an evolutionarily conserved gene regulatory network that controls eye formation in all seeing animals. The loss of eya leads to the complete elimination of the compound eye while forced expression of eya in non-retinal tissues is sufficient to induce ectopic eye formation. Within the developing retina eya is expressed in a dynamic pattern and is involved in tissue specification/determination, cell proliferation, apoptosis, and cell fate choice...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27922522/chronic-kidney-disease-predicts-coronary-plaque-vulnerability-an-optical-coherence-tomography-study
#2
Jiannan Dai, Lei Xing, Jingbo Hou, Haibo Jia, Sining Hu, Jinwei Tian, Lin Lin, Lulu Li, Yinchun Zhu, Gonghui Zheng, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
OBJECTIVE: The addition of cystatin C to creatinine in calculating the estimated glomerular filtration rate (eGFR) is known to improve the risk prediction for cardiovascular events. We sought to investigate the associations between eGFRs calculated by three Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations and coronary plaque phenotype by optical coherence tomography. PATIENTS AND METHODS: We analyzed 181 nonculprit plaques from 116 coronary artery disease patients...
December 2, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27922105/interplay-of-coupling-and-common-noise-at-the-transition-to-synchrony-in-oscillator-populations
#3
Anastasiya V Pimenova, Denis S Goldobin, Michael Rosenblum, Arkady Pikovsky
There are two ways to synchronize oscillators: by coupling and by common forcing, which can be pure noise. By virtue of the Ott-Antonsen ansatz for sine-coupled phase oscillators, we obtain analytically tractable equations for the case where both coupling and common noise are present. While noise always tends to synchronize the phase oscillators, the repulsive coupling can act against synchrony, and we focus on this nontrivial situation. For identical oscillators, the fully synchronous state remains stable for small repulsive coupling; moreover it is an absorbing state which always wins over the asynchronous regime...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920074/a-critical-appraisal-of-aspirin-in-secondary-prevention-is-less-more
#4
Giuseppe Gargiulo, Stephan Windecker, Pascal Vranckx, Charles Michael Gibson, Roxana Mehran, Marco Valgimigli
Aspirin represents the sine qua non for antiplatelet pharmacotherapy in patients with cardiovascular diseases because of its well-established role in secondary prevention and its widespread availability and affordability. Historical studies, conducted in an era that bears little resemblance to contemporary clinical practice, demonstrated large reductions in thrombotic risk when aspirin was compared with placebo, thus forming the evidence base promulgated in practice guidelines and recommendations. P2Y12 inhibitors have mostly been studied in addition to aspirin; dual-antiplatelet therapy proved superiority compared with aspirin monotherapy for the prevention of ischemic events, despite increased bleeding risks...
December 6, 2016: Circulation
https://www.readbyqxmd.com/read/27919300/a-randomised-placebo-controlled-trial-of-transcranial-pulsed-electromagnetic-fields-in-patients-with-multiple-chemical-sensitivity
#5
Marie Thi Dao Tran, Sine Skovbjerg, Lars Arendt-Nielsen, Karl Bang Christensen, Jesper Elberling
OBJECTIVE: To evaluate the efficacy of transcranially applied pulsed electromagnetic fields (PEMF) on functional impairments and symptom severity in multiple chemical sensitivity (MCS) patients. METHODS: The study was conducted as a nationwide trial in Denmark using a randomised, parallel-group, double-blind and placebo-controlled design. Sample size was estimated at 40 participants. Eligibility criteria were age 18-75 years and fulfilment of the MCS case criteria...
December 6, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27915430/protection-zone-in-a-diffusive-predator-prey-model-with-beddington-deangelis-functional-response
#6
Xiao He, Sining Zheng
In any reaction-diffusion system of predator-prey models, the population densities of species are determined by the interactions between them, together with the influences from the spatial environments surrounding them. Generally, the prey species would die out when their birth rate is too low, the habitat size is too small, the predator grows too fast, or the predation pressure is too high. To save the endangered prey species, some human interference is useful, such as creating a protection zone where the prey could cross the boundary freely but the predator is prohibited from entering...
December 3, 2016: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/27914481/conserved-3-utr-stem-loop-structure-in-l1-and-alu-transposons-in-human-genome-possible-role-in-retrotransposition
#7
Daria Grechishnikova, Maria Poptsova
BACKGROUND: In the process of retrotransposition LINEs use their own machinery for copying and inserting themselves into new genomic locations, while SINEs are parasitic and require the machinery of LINEs. The exact mechanism of how a LINE-encoded reverse transcriptase (RT) recognizes its own and SINE RNA remains unclear. However it was shown for the stringent-type LINEs that recognition of a stem-loop at the 3'UTR by RT is essential for retrotransposition. For the relaxed-type LINEs it is believed that the poly-A tail is a common recognition element between LINE and SINE RNA...
December 3, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27909520/surgical-ablation-of-atrial-fibrillation-is-electrical-isolation-of-the-pulmonary-veins-a-must
#8
REVIEW
Bart Maesen Md PhD, Ines Van Loo Md, Laurent Pison Md PhD, Mark La Meir Md PhD
Ablation of atrial fibrillation (AF) is a well-established treatment option for patients with symptomatic AF refractory to antiarrhythmic drugs. The cornerstone of catheter ablation is electrical isolation of the pulmonary veins, since the pulmonary veins are the most common location for triggers of AF. Electrical reconnection of the pulmonary veins is associated with arrhythmia recurrence and therefore diminishes long-term success of catheter ablation of AF. Therefore, durable pulmonary vein isolation remains a condition sine qua non for catheter ablation of AF...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908089/vibration-analysis-of-coupled-conical-cylindrical-spherical-shells-using-a-fourier-spectral-element-method
#9
Zhu Su, Guoyong Jin
This paper presents a Fourier spectral element method (FSEM) to analyze the free vibration of conical-cylindrical-spherical shells with arbitrary boundary conditions. Cylindrical-conical and cylindrical-spherical shells as special cases are also considered. In this method, each fundamental shell component (i.e., cylindrical, conical, and spherical shells) is divided into appropriate elements. The variational principle in conjunction with first-order shear deformation shell theory is employed to model the shell elements...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27906994/enhancing-hiv-testing-and-treatment-among-men-who-have-sex-with-men-in-china-a-pilot-model-with-two-rapid-tests-single-blood-draw-session-and-intensified-case-management-in-six-cities-in-2013
#10
Dapeng Zhang, Hongyan Lu, Minghua Zhuang, Guohui Wu, Hongjing Yan, Jun Xu, Xiaoli Wei, Chengmei Li, Sining Meng, Xiaojing Fu, Jinlei Qi, Peng Wang, Mei Luo, Min Dai, Ray Yip, Jiangping Sun, Zunyou Wu
OBJECTIVES: To explore models to improve HIV testing, linkage to care and treatment among men who have sex with men (MSM) in cooperation with community-based organizations (CBOs) in China. METHODS: We introduced a new model for HIV testing services targeting MSM in six cities in 2013.These models introduced provision of rapid HIV testing by CBO staff and streamlined processes for HIV screening, confirmation of initial reactive screening results, and linkage to care among diagnosed people...
2016: PloS One
https://www.readbyqxmd.com/read/27906859/recent-advances-in-nuclear-medicine-in-endocrine-oncology
#11
Markus Luster, Andreas Pfestroff, Frederik A Verburg
PURPOSE OF REVIEW: The purpose is to review recent advances concerning the role of nuclear medicine in endocrine oncology. RECENT FINDINGS: For I therapy of thyroid cancer a thyrotropin (TSH) more than 30 mU/l has for many years been deemed a condition sine qua non. However, new data show that patients with lower TSH levels at the time of ablation have the same rate of successful ablation as those with TSH more than 30 mU/l.I-124 combined integrated positron emission tomography and computed X-ray tomography was shown to be highly accurate in predicting findings on posttherapy radioiodine scanning and was shown to have a high prognostic power...
January 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/27903898/transfer-rna-is-highly-unstable-during-early-amino-acid-starvation-in-escherichia-coli
#12
Sine Lo Svenningsen, Mette Kongstad, Thomas Søndergaard Stenum, Ana J Muñoz-Gómez, Michael A Sørensen
Due to its long half-life compared to messenger RNA, bacterial transfer RNA is known as stable RNA. Here, we show that tRNAs become highly unstable as part of Escherichia coli's response to amino acid starvation. Degradation of the majority of cellular tRNA occurs within twenty minutes of the onset of starvation for each of several amino acids. Both the non-cognate and cognate tRNA for the amino acid that the cell is starving for are degraded, and both charged and uncharged tRNA species are affected. The alarmone ppGpp orchestrates the stringent response to amino acid starvation...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27903724/a-comparison-of-visual-response-properties-in-the-lateral-geniculate-nucleus-and-primary-visual-cortex-of-awake-and-anesthetized-mice
#13
Séverine Durand, Ramakrishnan Iyer, Kenji Mizuseki, Saskia de Vries, Stefan Mihalas, R Clay Reid
: The cerebral cortex of the mouse has become one of the most important systems for studying information processing and the neural correlates of behavior. Multiple studies have examined the first stages of visual cortical processing: primary visual cortex (V1) and its thalamic inputs from the dorsal lateral geniculate nucleus (dLGN), but more rarely in the lateral posterior nucleus (LP) in mice. Multiple single-unit surveys of dLGN and V1, both with electrophysiology and two-photon calcium imaging, have described receptive fields in anesthetized animals...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27902702/selective-inhibitor-of-nuclear-export-sine-compounds-alter-new-world-alphavirus-capsid-localization-and-reduce-viral-replication-in-mammalian-cells
#14
Lindsay Lundberg, Chelsea Pinkham, Cynthia de la Fuente, Ashwini Brahms, Nazly Shafagati, Kylie M Wagstaff, David A Jans, Sharon Tamir, Kylene Kehn-Hall
The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185, KPT-335 (verdinexor), and KPT-350, target the host's primary nuclear export protein, CRM1, in a manner similar to the archetypical inhibitor Leptomycin B. One major limitation of Leptomycin B is its irreversible binding to CRM1; which SINE compounds alleviate because they are slowly reversible...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27898892/transcriptome-analyses-identify-five-transcription-factors-differentially-expressed-in-the-hypothalamus-of-post-versus-prepubertal-brahman-heifers
#15
M R S Fortes, L T Nguyen, M M D C A Weller, A Cánovas, A Islas-Trejo, L R Porto-Neto, A Reverter, S A Lehnert, G B Boe-Hansen, M G Thomas, J F Medrano, S S Moore
Puberty onset is a developmental process influenced by genetic determinants, environment, and nutrition. Mutations and regulatory gene networks constitute the molecular basis for the genetic determinants of puberty onset. The emerging knowledge of these genetic determinants presents opportunities for innovation in the breeding of early pubertal cattle. This paper presents new data on hypothalamic gene expression related to puberty in (Brahman) in age- and weight-matched heifers. Six postpubertal heifers were compared with 6 prepubertal heifers using whole-genome RNA sequencing methodology for quantification of global gene expression in the hypothalamus...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895125/lineage-specific-soxr-mediated-regulation-of-an-endoribonuclease-protects-non-enteric-bacteria-from-redox-active-compounds
#16
Jisun Kim, Chulwoo Park, James A Imlay, Woojun Park
Bacteria use redox-sensitive transcription factors to coordinate responses to redox stress. The [2Fe-2S] cluster-containing transcription factor SoxR is particularly tuned to protect cells against redox-active compounds (RACs). In enteric bacteria, SoxR is paired with a second transcription factor, SoxS, that activates downstream effectors. However, SoxS is absent in non-enteric bacteria, raising questions as to how SoxR functions. Here, we first show that SoxR of Acinetobacter oleivorans displayed similar activation profiles in response to RACs as did its homolog from Escherichia coli, but controlled a different set of target genes, including sinE, which encodes an endoribonuclease...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27878599/-acoustic-reflexes-of-children-with-and-without-central-auditory-processing-disorders
#17
S Kunze, A Nickisch, H von Voss, V Mall
BACKGROUND: According to international standards, determination of acoustic reflex thresholds (ART) is one of the established objective measurements in the diagnostic workup of central auditory processing disorders (CAPD). However, there is still no evidence for the significance of ART in CAPD diagnosis. PATIENTS AND METHODS: This study tested 57 children with proven CAPD and 50 healthy children (control group) with regard to group differences in mean ART (sine tones or bandpass-filtered noise)...
November 23, 2016: HNO
https://www.readbyqxmd.com/read/27876638/changes-in-acoustic-startle-reflex-in-rats-induced-by-playback-of-22-khz-calls
#18
Hideaki Inagaki, Takahiro Ushida
In aversive or dangerous situations, adult rats emit long characteristic ultrasonic calls, often termed "22-kHz calls," which have been suggested to play the role of alarm calls. Although the playback experiment is one of the most effective ways to investigate the alarming properties of 22-kHz calls, clear behavioral evidence showing the anxiogenic effects of these playback stimuli has not been obtained to date. In this study, we investigated whether playback of 22-kHz calls or synthesized sine tones could change the acoustic startle reflex (ASR), enhancement of which is widely considered to be a reliable index of anxiety-related negative affective states in rats...
November 19, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27875232/a-novel-algorithm-for-learning-sparse-spatio-spectral-patterns-for-event-related-potentials
#19
Chaohua Wu, Ke Lin, Wei Wu, Xiaorong Gao
Recent years have witnessed brain-computer interface (BCI) as a promising technology for integrating human intelligence and machine intelligence. Currently, event-related potential (ERP)-based BCI is an important branch of noninvasive electroencephalogram (EEG)-based BCIs. Extracting ERPs from a limited number of trials remains challenging due to their low signal-to-noise ratio (SNR) and low spatial resolution caused by volume conduction. In this paper, we propose a probabilistic model for trial-by-trial concatenated EEG, in which the concatenated ERPs are expressed as a linear combination of a set of discrete sine and cosine bases...
November 17, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27870063/the-diatom-phaeodactylum-tricornutum-adjusts-nonphotochemical-fluorescence-quenching-capacity-in-response-to-dynamic-light-via-fine-tuned-lhcx-and-xanthophyll-cycle-pigment-synthesis
#20
Bernard Lepetit, Gautier Gélin, Mariana Lepetit, Sabine Sturm, Sascha Vugrinec, Alessandra Rogato, Peter G Kroth, Angela Falciatore, Johann Lavaud
Diatoms contain a highly flexible capacity to dissipate excessively absorbed light by nonphotochemical fluorescence quenching (NPQ) based on the light-induced conversion of diadinoxanthin (Dd) into diatoxanthin (Dt) and the presence of Lhcx proteins. Their NPQ fine regulation on the molecular level upon a shift to dynamic light conditions is unknown. We investigated the regulation of Dd + Dt amount, Lhcx gene and protein synthesis and NPQ capacity in the diatom Phaeodactylum tricornutum after a change from continuous low light to 3 d of sine (SL) or fluctuating (FL) light conditions...
November 21, 2016: New Phytologist
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