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https://www.readbyqxmd.com/read/29140583/association-study-of-ndst3-gene-for-schizophrenia-bipolar-disorder-major-depressive-disorder-in-the-han-chinese-population
#1
Lin Wang, Jianhua Chen, Zhiqiang Li, Weiming Sun, Boyu Chen, Sining Li, Weidong Li, Dajiang Lu, Yonggang Wang, Yongyong Shi
The NDST3 gene at 4q26 was a functional candidate gene for mental disorders. Recently, a novel genome-wide significant risk locus at chromosome 4q26 was identified and the top single nucleotide polymorphism rs11098403 in the vicinity of NDST3 gene was reported to confer risk of schizophrenia in Caucasian. Nevertheless, association between NDST3 gene polymorphisms and schizophrenia, bipolar disorder, or major depressive disorders has not been well studied in the Han Chinese population. To further investigate whether NDST3 is a risk gene for these mental disorders, we genotyped and analyzed eight tag SNPs (rs11098403, rs10857057, rs2389521, rs4833564, rs6837896, rs7689157, rs3817274, rs609512) covering NDST3 gene in 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls of Chinese origin...
November 15, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29140351/design-of-optical-wavelength-demultiplexer-based-on-off-axis-meta-lens
#2
Yi Zhou, Rui Chen, Yungui Ma
We propose an off-axis meta-lens-based optical wavelength demultiplexer. The performance of the device initially proposed with four output channels (1527-1596 nm, channel spacing 23 nm) composed of an optical fiber array is analyzed by both scalar diffraction theory and ray tracing method. The results show that the fiber energy coupling efficiency of the demultiplexer could be larger than 89% and the channel bandwidth is about 9 nm. Influences of the two key parameters, focal length f and off-axis angle α, are also investigated...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29137251/exportin-1-xpo1-inhibition-leads-to-restoration-of-tumor-suppressor-mir-145-and-consequent-suppression-of-pancreatic-cancer-cell-proliferation-and-migration
#3
Asfar S Azmi, Yiwei Li, Irfana Muqbil, Amro Aboukameel, William Senapedis, Erkan Baloglu, Yosef Landesman, Sharon Shacham, Michael G Kauffman, Philip A Philip, Ramzi M Mohammad
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer related deaths in the United States with a majority of these patients dying from aggressively invasive and metastatic disease. There is growing evidence that suggests an important role for microRNAs (miRNAs) in the pathobiology of aggressive PDAC. In this study, we found that the expression of miR-145 was significantly lower in PDAC cells when compared to normal pancreatic duct epithelial cells. Here we show that inhibition of the nuclear exporter protein exportin 1 (XPO1; also known as chromosome maintenance region 1 [CRM1]) by siRNA knockdown or by the Selective Inhibitor of Nuclear Export (SINE) compound (KPT-330; selinexor) increases miR-145 expression in PDAC cells resulting in the decreased cell proliferation and migration capacities...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29129732/chromatic-summation-and-receptive-field-properties-of-blue-on-and-blue-off-cells-in-marmoset-lateral-geniculate-nucleus
#4
C D Eiber, A N J Pietersen, N Zeater, S G Solomon, P R Martin
The "blue-on" and "blue-off" receptive fields in retina and dorsal lateral geniculate nucleus (LGN) of diurnal primates combine signals from short-wavelength sensitive (S) cone photoreceptors with signals from medium/long wavelength sensitive (ML) photoreceptors. Three questions about this combination remain unresolved. Firstly, is the combination of S and ML signals in these cells linear or non-linear? Secondly, how does the timing of S and ML inputs to these cells influence their responses? Thirdly, is there spatial antagonism within S and ML subunits of the receptive field of these cells? We measured contrast sensitivity and spatial frequency tuning for four types of drifting sine gratings: S cone isolating, ML cone isolating, achromatic (S + ML), and counterphase chromatic (S - ML), in extracellular recordings from LGN of marmoset monkeys...
November 9, 2017: Vision Research
https://www.readbyqxmd.com/read/29128970/cord-serum%C3%A2-25-hydroxyvitamin-d-is-not-associated-with-cranial-anthropometrics-in-infants-up-to-6%C3%A2-months-of-age-an-odense-child-cohort-study
#5
Sissil Egge, Nikolas Christensen, Sine Lykkedegn, Tina Kold Jensen, Henrik Thybo Christesen
Skull changes are poorly described in vitamin D insufficiency [serum 25-hydroxyvitamin D (s-25(OH)D) 25-50 nmol/L]. We aimed to investigate factors associated with cranial anthropometrics in infants, especially s-25(OH)D. In infants 2.5-6 months old from the Odense Child Cohort, associations between cord and pregnancy s-25(OH)D and anterior fontanel area (n = 765), head circumference (HC, n = 1776) and head shape (n = 1527) were investigated along with other factors. Age was corrected for preterm birth...
November 11, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29127402/the-nature-of-ancient-egyptian-copper-containing-carbon-inks-is-revealed-by-synchrotron-radiation-based-x-ray-microscopy
#6
Thomas Christiansen, Marine Cotte, René Loredo-Portales, Poul Erik Lindelof, Kell Mortensen, Kim Ryholt, Sine Larsen
For the first time it is shown that carbon black inks on ancient Egyptian papyri from different time periods and geographical regions contain copper. The inks have been investigated using synchrotron-based micro X-ray fluorescence (XRF) and micro X-ray absorption near-edge structure spectroscopy (XANES) at the European Synchrotron Radiation Facility (ESRF). The composition of the copper-containing carbon inks showed no significant differences that could be related to time periods or the geographical locations...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29125381/pleiotropy-in-drosophila-organogenesis-mechanistic-insights-from-combgap-and-the-retinal-determination-gene-network
#7
Trevor L Davis, Ilaria Rebay
Master regulatory transcription factors cooperate in networks to shepherd cells through organogenesis. In the Drosophila eye, a collection of master control proteins known as the retinal determination gene network (RDGN) switches the direction and targets of its output to choreograph developmental transitions, but the molecular partners that enable such regulatory flexibility are not known. We recently showed that two RDGN members, Eyes absent (Eya) and Sine oculis (So), promote exit from the terminal cell cycle known as the second mitotic wave (SMW) to permit differentiation...
November 10, 2017: Fly
https://www.readbyqxmd.com/read/29124958/streptomyces-sp-is-a-powerful-biotechnological-tool-for-the-biodegradation-of-hch-isomers-biochemical-and-molecular-basis
#8
S A Cuozzo, P E Sineli, J Davila Costa, G Tortella
Actinobacteria are well-known degraders of toxic materials that have the ability to tolerate and remove organochloride pesticides; thus, they are used for bioremediation. The biodegradation of organochlorines by actinobacteria has been demonstrated in pure and mixed cultures with the concomitant production of metabolic intermediates including γ-pentachlorocyclohexene (γ-PCCH); 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN); 1,2-dichlorobenzene (1,2-DCB), 1,3-dichlorobenzene (1,3-DCB), or 1,4-dichlorobenzene (1,4-DCB); 1,2,3-trichlorobenzene (1,2,3-TCB), 1,2,4-trichlorobenzene (1,2,4-TCB), or 1,3,5-trichlorobenzene (1,3,5-TCB); 1,3-DCB; and 1,2-DCB...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29123436/development-and-retrospective-clinical-assessment-of-a-patient-specific-closed-form-integro-differential-equation-model-of-plasma-dilution
#9
Glen Atlas, John K-J Li, Shawn Amin, Robert G Hahn
A closed-form integro-differential equation (IDE) model of plasma dilution (PD) has been derived which represents both the intravenous (IV) infusion of crystalloid and the postinfusion period. Specifically, PD is mathematically represented using a combination of constant ratio, differential, and integral components. Furthermore, this model has successfully been applied to preexisting data, from a prior human study, in which crystalloid was infused for a period of 30 minutes at the beginning of thyroid surgery...
2017: Biomedical Engineering and Computational Biology
https://www.readbyqxmd.com/read/29122722/stimulus-invariant-auditory-cortex-threat-encoding-during-fear-conditioning-with-simple-and-complex-sounds
#10
Matthias Staib, Dominik R Bach
Learning to predict threat depends on amygdala plasticity and does not require auditory cortex (ACX) when threat predictors (conditioned stimuli, CS) are simple sine tones. However, ACX is required in rodents to learn from some naturally occurring CS. Yet, the precise function of ACX, and whether it differs for different CS types, is unknown. Here, we address how ACX encodes threat predictions during human fear conditioning using functional magnetic resonance imaging (fMRI) with multivariate pattern analysis...
November 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/29115206/bronchoscopy-in-children-suspected-of-lower-airway-aspiration
#11
Sine Holst-Albrechtsen, Søren Kristensen, Knud Larsen
INTRODUCTION: Foreign body aspiration (FBA) of the bronchial tree may be a life-threatening condition in children. This retrospective study explores the anamnestic, clinical and objective findings in patients with FBA to the lungs and evaluates the frequency and outcome of the condition in patients in the age group of highest risk. METHOD: Medical files from patients below 18 years of age who had a foreign body removed from the lungs in our hospital were extracted using the procedure code for removal of foreign bodies in the lower airways ("Danish Patient Register") in the period 1990-2013...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29108015/mutations-that-impair-eyes-absent-tyrosine-phosphatase-activity-in-vitro-reduce-robustness-of-retinal-determination-gene-network-output-in-drosophila
#12
Trevor L Davis, Charlene S L Hoi, Ilaria Rebay
A limited collection of signaling networks and transcriptional effectors directs the full spectrum of cellular behaviors that comprise development. One mechanism to diversify regulatory potential is to combine multiple biochemical activities into the same protein. Exemplifying this principle of modularity, Eyes absent (Eya), originally identified as a transcriptional co-activator within the retinal determination gene network (RDGN), also harbors tyrosine and threonine phosphatase activities. Although mounting evidence argues for the importance of Eya's phosphatase activities to mammalian biology, genetic rescue experiments in Drosophila have shown that the tyrosine phosphatase function is dispensable for normal development...
2017: PloS One
https://www.readbyqxmd.com/read/29103173/a-role-for-the-mutagenic-dna-self-catalyzed-depurination-mechanism-in-the-evolution-of-7sl-derived-rnas
#13
Maxwell P Gold, Jacques R Fresco
The Alu element, the most prevalent SINE (short interspersed element) in the human genome, is one of the many RNA-encoding genes that evolved from the 7SL RNA gene. During analysis of the evolution of 7SL-derived RNAs, two distinct evolutionary intermediates capable of self-catalyzed DNA depurination (SDP) were identified. These SDP sequences spontaneously create apurinic sites that can result in increased mutagenesis due to their error-prone repair. This DNA self-depurination mechanism has been shown both in vitro and in vivo to lead to substitution and short frameshift mutations at a frequency that far exceeds their occurrence due to random errors in DNA replication...
October 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29102622/more-superimposition-for-contrast-modulated-than-luminance-modulated-stimuli-during-binocular-rivalry
#14
Jan Skerswetat, Monika A Formankiewicz, Sarah J Waugh
Luminance-modulated noise (LM) and contrast-modulated noise (CM) gratings were presented with interocularly correlated, uncorrelated and anti-correlated binary noise to investigate their contributions to mixed percepts, specifically piecemeal and superimposition, during binocular rivalry. Stimuli were sine-wave gratings of 2c/deg presented within 2 deg circular apertures. The LM stimulus contrast was 0.1 and the CM stimulus modulation depth was 1.0, equating to approximately 5 and 7 times detection threshold, respectively...
November 1, 2017: Vision Research
https://www.readbyqxmd.com/read/29101633/numerical-study-of-dynamic-glottis-and-tidal-breathing-on-respiratory-sounds-in-a-human-upper-airway-model
#15
Jinxiang Xi, Zhaoxuan Wang, Khaled Talaat, Carri Glide-Hurst, Haibo Dong
BACKGROUND: Human snores are caused by vibrating anatomical structures in the upper airway. The glottis is a highly variable structure and a critical organ regulating inhaled flows. However, the effects of the glottis motion on airflow and breathing sound are not well understood, while static glottises have been implemented in most previous in silico studies. The objective of this study is to develop a computational acoustic model of human airways with a dynamic glottis and quantify the effects of glottis motion and tidal breathing on airflow and sound generation...
November 3, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29097043/incidence-and-risk-factors-for-retrograde-type-a-dissection-and-stent-graft-induced-new-entry-after-thoracic-endovascular-aortic-repair
#16
Tao Ma, Zhi Hui Dong, Wei Guo Fu, Da Qiao Guo, Xin Xu, Bin Chen, Jun Hao Jiang, Jue Yang, Zhen Yu Shi, Ting Zhu, Yun Shi, Bao Hong Jiang, Xiao Yun Xu
OBJECTIVE: Stent graft (SG)-induced new entry (SINE) and retrograde type A dissection (RTAD) are serious device-related complications occurring after thoracic endovascular aortic repair (TEVAR) for Stanford type B aortic dissection (TBAD) and may lead to endograft-related complications including retrograde dissection and death. The purpose of this study was to investigate the incidence and risk factors for the development of RTAD and SINE after TEVAR for TBAD and to identify the complications associated with this...
October 30, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29092104/where-should-patient-safety-be-installed
#17
David M Sine, Doug Paull
The structure of an organization is important, and structure has a profound influence on the way people work and what gets done. Where work units and individuals in an organization are placed, to whom they report, and with whom they are grouped signals power, prestige, and privilege. It also divides workers into groups with common interests and motivations. The question is, where should patient safety be placed in a health care organization? Such a question can be answered only within a framework of understanding that gives a clear definition to patient safety...
November 1, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29071434/does-alignment-of-the-limb-and-tibial-width-determine-relative-narrowing-between-compartments-when-planning-mechanically-aligned-tka
#18
Avreeta K Singh, Alexander J Nedopil, Stephen M Howell, Maury L Hull
INTRODUCTION: We determined (1) the range of the hip-knee-ankle (HKA) angle in the native or pre-arthritic limbs of patients with a contralateral total knee arthroplasty (TKA); and when mechanical alignment is planned (2) the relationships between the HKA angle and the tibial width, and the relative narrowing between the medial and lateral compartments and (3) the effect of tibial width on the range of narrowing. METHODS: The HKA angle, distal lateral femoral angle (DLFA), and proximal medial tibial angle (PMTA) were measured on the native limb of 102 subjects (53 female) treated with contralateral TKA...
October 25, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29069598/brain-wide-mapping-of-endogenous-serotonergic-transmission-via-chemogenetic-fmri
#19
Andrea Giorgi, Sara Migliarini, Alberto Galbusera, Giacomo Maddaloni, Maddalena Mereu, Giulia Margiani, Marta Gritti, Silvia Landi, Francesco Trovato, Sine Mandrup Bertozzi, Andrea Armirotti, Gian Michele Ratto, Maria Antonietta De Luca, Raffaella Tonini, Alessandro Gozzi, Massimo Pasqualetti
Serotonin-producing neurons profusely innervate brain regions via long-range projections. However, it remains unclear whether and how endogenous serotonergic transmission specifically influences regional or global functional activity. We combined designed receptors exclusively activated by designed drugs (DREADD)-based chemogenetics and functional magnetic resonance imaging (fMRI), an approach we term "chemo-fMRI," to causally probe the brain-wide substrates modulated by endogenous serotonergic activity...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/29068586/systemic-sclerosis-sine-scleroderma
#20
REVIEW
Eugeniusz J Kucharz, Magdalena Kopeć-Mędrek
Systemic sclerosis is a rare generalized disease with scleroderma, i.e. skin thickening as one of the most common symptoms. The disease has 2 main subsets, diffuse and limited forms. The subset known as systemic sclerosis sine scleroderma (ssSSc) is a very rare subset characterized by the total or partial absence of cutaneous manifestations of systemic sclerosis with the occurrence of internal organ involvement and serologic abnormalities. The classification of ssSSc into 3 groups was proposed. Type I (complete) is characterized by the lack of any cutaneous changes typical for the disease at least until systemic sclerosis-related insufficiency of any internal organ occurs...
August 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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