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https://www.readbyqxmd.com/read/28318139/chronic-total-occlusion-is-associated-with-a-higher-incidence-of-malapposition-and-uncovered-stent-struts-oct-findings-at-6-months-following-des-implantation
#1
Haibo Jia, Sining Hu, Huimin Liu, Yinchun Zhu, Chun-Yang Zhe, Lulu Li, Irina Mustafina, Jingbo Hou, Shaosong Zhang, Bo Yu
OBJECTIVES: To compare stent coverage and malapposition in patients with chronic total occlusion (CTO) lesions and non-CTO lesions (including lipid-rich plaque [LRP] and non-lipid-rich plaque [non-LRP]) after drug-eluting stent (DES) implantation by optical coherence tomography (OCT). BACKGROUND: Different initial lesion characteristics may be related to heterogeneous vessel responses after DES implantation. However, the vessel response in patients with CTO and non-CTO lesions after stenting is unclear...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28318137/plaque-erosion-delays-vascular-healing-after-drug-eluting-stent-implantation-in-patients-with-acute-coronary-syndrome-an-in-vivo-optical-coherence-tomography-study
#2
Sining Hu, Chao Wang, Chunyang Zhe, Yinchun Zhu, Taishi Yonetsu, Haibo Jia, Jingbo Hou, Shaosong Zhang, Ik-Kyung Jang, Bo Yu
OBJECTIVES: To compare vascular healing after drug-eluting stent (DES) implantation between plaque rupture (PR) and plaque erosion (PE). BACKGROUND: Vascular response after stent implantation in patients with PR has been extensively studied. Little is known about vascular healing after stent implantation in PE. METHODS: Sixty-five ACS patients who received optical coherence tomography (OCT) imaging of the culprit lesions both before and after stent implantation at baseline as well as at 6 months were included in this study...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28314956/evolution-of-mhc-based-technologies-used-for-detection-of-antigen-responsive-t-cells
#3
REVIEW
Amalie Kai Bentzen, Sine Reker Hadrup
T cell-mediated recognition of peptide-major histocompatibility complex (pMHC) class I and II molecules is crucial for the control of intracellular pathogens and cancer, as well as for stimulation and maintenance of efficient cytotoxic responses. Such interactions may also play a role in the development of autoimmune diseases. Novel insights into this mechanism are crucial to understanding disease development and establishing new treatment strategies. MHC multimers have been used for detection of antigen-responsive T cells since the first report by Altman et al...
March 17, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28303549/-the-anopheles-gambiae-species-complex-and-kdr-resistance-gene-at-the-periphery-of-douala-cameroon
#4
P Ntonga Akono, A Mbouangoro, A Mbida Mbida, C Ndo, M F Peka Nsangou, S Kekeunou
This study was conducted from May to June 2015 in Yassa (industrialized area) and Logbessou (non-industrialized area), two peri-urban areas of the city of Douala, Cameroon with the aim of an assessment of the spatial distribution of the gambiae complex, the determination of their resistance to insecticides and the distribution of the Kdr mutation. Mosquito larvae were collected by the dipping method and nursed to adult stage. The sensitivity of adult Anopheles gambiae s.l. populations to DDT and pyrethroids was assessed following WHO protocol...
March 16, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28298302/visual-and-presaccadic-activity-in-area-8ar-of-the-macaque-monkey-lateral-prefrontal-cortex
#5
Kelly R Bullock, Florian Pieper, Adam J Sachs, Julio C Martinez-Trujillo
Common trends observed in many visual and oculomotor-related cortical areas include retinotopically organized receptive and movement fields exhibiting a Gaussian shape and increasing size with eccentricity. These trends are demonstrated in the frontal eye fields (FEF), many visual areas, and the superior colliculus (SC), but have not been thoroughly characterized in prearcuate area 8Ar of the prefrontal cortex. This is important since area 8Ar, located anterior to the FEF, is more cytoarchitectonically similar to prefrontal areas than premotor areas...
March 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28297944/large-amplitude-nonlinear-normal-modes-of-the-discrete-sine-lattices
#6
Valeri V Smirnov, Leonid I Manevitch
We present an analytical description of the large-amplitude stationary oscillations of the finite discrete system of harmonically coupled pendulums without any restrictions on their amplitudes (excluding a vicinity of π). Although this model has numerous applications in different fields of physics, it was studied earlier in the infinite limit only. The discrete chain with a finite length can be considered as a well analytical analog of the coarse-grain models of flexible polymers in the molecular dynamics simulations...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28295322/the-%C3%AE-%C3%AE-circular-scanning-with-large-range-and-low-noise
#7
J Liu, X You, Y Wang, K Gu, C Liu, J Tan
A circular-route scanning method called α-β circular scanning is proposed and realized using sinusoidal signals with a constant phase difference of π/2. Experiments show that the circular scanning range of α-β circular scanning is 57% greater than the rectangular scanning range of raster scanning within an effective optical field of view. Moreover, the scanning speed is improved by 7.8% over raster scanning because the whole sine signal is utilized in α-β circular scanning whereas the flyback area of the saw-tooth signal needs to be discarded in raster scanning...
March 15, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28294186/a-scientific-report-on-heat-transfer-analysis-in-mixed-convection-flow-of-maxwell-fluid-over-an-oscillating-vertical-plate
#8
Ilyas Khan, Nehad Ali Shah, L C C Dennis
This scientific report investigates the heat transfer analysis in mixed convection flow of Maxwell fluid over an oscillating vertical plate with constant wall temperature. The problem is modelled in terms of coupled partial differential equations with initial and boundary conditions. Some suitable non-dimensional variables are introduced in order to transform the governing problem into dimensionless form. The resulting problem is solved via Laplace transform method and exact solutions for velocity, shear stress and temperature are obtained...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289448/when-is-cough-functional-and-how-should-it-be-treated
#9
REVIEW
Miles Weinberger, Boris Lockshin
KEY POINTS: Habit cough is most commonly characterised by a repetitive loud barking cough that persists for prolonged periods.The cough interferes with normal activity and substantially decreases the quality of life.The sine qua non is the total absence of this troublesome cough once asleep.The age distribution ranges from 4 years to late adolescence, with 85% of cases occurring from 8 to 14 years of age; similar cough in adults is much less common and poorly characterised.Pharmacological treatment is ineffective...
March 2017: Breathe
https://www.readbyqxmd.com/read/28288123/optogenetic-control-with-a-photocleavable-protein-phocl
#10
Wei Zhang, Alexander W Lohman, Yevgeniya Zhuravlova, Xiaocen Lu, Matthew D Wiens, Hiofan Hoi, Sine Yaganoglu, Manuel A Mohr, Elena N Kitova, John S Klassen, Periklis Pantazis, Roger J Thompson, Robert E Campbell
To expand the range of experiments that are accessible with optogenetics, we developed a photocleavable protein (PhoCl) that spontaneously dissociates into two fragments after violet-light-induced cleavage of a specific bond in the protein backbone. We demonstrated that PhoCl can be used to engineer light-activatable Cre recombinase, Gal4 transcription factor, and a viral protease that in turn was used to activate opening of the large-pore ion channel Pannexin-1.
March 13, 2017: Nature Methods
https://www.readbyqxmd.com/read/28276958/disease-activity-in-and-quality-of-life-of-patients-with-psoriatic-arthritis-mutilans-the-nordic-pam-study
#11
U Lindqvist, B Gudbjornsson, L Iversen, L Laasonen, L Ejstrup, T Ternowitz, M Ståhle
OBJECTIVE: To describe the social status and health-related quality of life of patients with psoriatic arthritis mutilans (PAM) in the Nordic countries. METHOD: Patients with at least one mutilated joint confirmed by radiology were studied. Disease activity involving joints and skin, physician-assessed disease activity, and patient's education and work status were recorded. Data from the 36-item Short Form Health Survey, Health Assessment Questionnaire and Dermatology Life Quality Index questionnaire were gathered and correlated with disease duration, pain, and general well-being (visual analogue scale)...
February 10, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28275316/cohort-description-the-danish-study-of-functional-disorders
#12
Thomas Meinertz Dantoft, Jeanette Frost Ebstrup, Allan Linneberg, Sine Skovbjerg, Anja Lykke Madsen, Jesper Mehlsen, Louise Brinth, Lene Falgaard Eplov, Tina Wisbech Carstensen, Andreas Schroder, Per Klausen Fink, Erik Lykke Mortensen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
The Danish study of Functional Disorders (DanFunD) cohort was initiated to outline the epidemiology of functional somatic syndromes (FSS) and is the first larger coordinated epidemiological study focusing exclusively on FSS. FSS are prevalent in all medical settings and can be defined as syndromes that, after appropriate medical assessment, cannot be explained in terms of a conventional medical or surgical disease. FSS are frequent and the clinical importance varies from vague symptoms to extreme disability...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28273101/classical-and-adaptive-control-of-ex-vivo-skeletal-muscle-contractions-using-functional-electrical-stimulation-fes
#13
Paola Jaramillo Cienfuegos, Adam Shoemaker, Robert W Grange, Nicole Abaid, Alexander Leonessa
Functional Electrical Stimulation is a promising approach to treat patients by stimulating the peripheral nerves and their corresponding motor neurons using electrical current. This technique helps maintain muscle mass and promote blood flow in the absence of a functioning nervous system. The goal of this work is to control muscle contractions from FES via three different algorithms and assess the most appropriate controller providing effective stimulation of the muscle. An open-loop system and a closed-loop system with three types of model-free feedback controllers were assessed for tracking control of skeletal muscle contractions: a Proportional-Integral (PI) controller, a Model Reference Adaptive Control algorithm, and an Adaptive Augmented PI system...
2017: PloS One
https://www.readbyqxmd.com/read/28272323/neurotoxic%C3%A2-doses%C3%A2-of%C3%A2-chronic%C3%A2-methamphetamine%C3%A2-trigger%C3%A2-retrotransposition%C3%A2-of%C3%A2-the%C3%A2-identifier%C3%A2-element%C3%A2-in%C3%A2-rat%C3%A2-dorsal%C3%A2-dentate%C3%A2-gyrus
#14
Anna Moszczynska, Kyle J Burghardt, Dongyue Yu
Short interspersed elements (SINEs) are typically silenced by DNA hypermethylation in somatic cells, but can retrotranspose in proliferating cells during adult neurogenesis. Hypomethylation caused by disease pathology or genotoxic stress leads to genomic instability of SINEs. The goal of the present investigation was to determine whether neurotoxic doses of binge or chronic methamphetamine (METH) trigger retrotransposition of the identifier (ID) element, a member of the rat SINE family, in the dentate gyrus genomic DNA...
March 6, 2017: Genes
https://www.readbyqxmd.com/read/28261794/nicotinic-acetylcholine-receptors-at-the-single-channel-level
#15
REVIEW
Cecilia Bouzat, Steven M Sine
Over the past four decades, the patch clamp technique and nicotinic acetylcholine (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while their union has spurred innumerable advances in life science research. A member and prototype of the superfamily of pentameric ligand-gated ion channels, the nACh receptor is a chemo-electric transducer, binding nerve-released ACh and rapidly opening its channel to cation flow to elicit cellular excitation...
March 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28260637/does-autonomy-for-public-hospitals-in-developing-countries-increase-performance-evidence-based-case-studies
#16
REVIEW
Willy De Geyndt
OBJECTIVES: Governments in middle and low income countries have sought ways for the past decades to make their public hospitals more performing. The objectives of this assessment are to: (a) synthesize the experience of eleven countries at granting autonomy to their public hospitals and the obstacles encountered; (b) deduce which autonomy policies have or have not been effective documenting successes and failures; and (c) propose evidence-based recommendations to policy makers. DATA SOURCES: Data for five countries are derived from the author's participation in the autonomy process augmented by current updates provided by national colleagues...
February 27, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28254631/impairment-in-active-navigation-from-trauma-and-post-traumatic-stress-disorder
#17
Jessica K Miller, Siné McDougall, Sarah Thomas, Jan M Wiener
The study investigated the impact of trauma exposure and of Post-Traumatic Stress Disorder (PTSD) on spatial processing and active navigation in a sample (n=138) comprising civilians (n=91), police officers (n=22) and veterans (n=27). Individuals with previous trauma exposure exhibited significantly poorer hippocampal-dependent (allocentric) navigation performance on active navigation in a virtual environment (the Alternative Route task) regardless of whether or not they had PTSD (scoring above 20 on the PTSD Diagnostic Scale)...
February 27, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28254365/macrotopographic-closure-promotes-tissue-growth-and-osteogenesis-in-vitro
#18
Laura Juignet, Baptiste Charbonnier, Virginie Dumas, Wafa Bouleftour, Mireille Thomas, Coralie Laurent, Laurence Vico, Nathalie Douard, David Marchat, Luc Malaval
While the impact of substrate topographies at nano- and microscale on bone cell behavior has been particularly well documented, very few studies have analyzed the role of substrate closure at a tissular level. Moreover, these have focused on matrix deposition rather than on osteoblastic differentiation. In the present work, mouse calvaria cells were grown for 15days on hydroxyapatite (HA) ceramics textured with three different macrogrooves shapes ((**)100µm): 1 sine and 2 triangle waveforms. We found that macrotopography favors cell attachment, and that bone-like tissue growth and organization are promoted by a tight "closure angle" of the substrate geometry...
February 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28253653/on-the-localization-of-high-frequency-sinusoidally-amplitude-modulated-tones-in-free-field
#19
Eric J Macaulay, Brad Rakerd, Thomas J Andrews, William M Hartmann
Previous headphone experiments have shown that listeners can lateralize high-frequency sine-wave amplitude-modulated (SAM) tones based on interaural time differences in the envelope. However, when SAM tones are presented to listeners in free field or in a room, diffraction by the head or reflections from room surfaces alter the modulation percentages and change the shapes of the envelopes, potentially degrading the envelope cue. Amplitude modulation is transformed into mixed modulation. This article presents a mathematical transformation between the six spectral parameters for a modulated tone and six mixed-modulation parameters for each ear...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28251977/-4-5si-and-4-5sh-rnas-expression-in-various-rodent-organs-and-abundance-and-distribution-in-the-cell
#20
K A Tatosyan, A P Koval, I K Gogolevskaya, D A Kramerov
Studying the structure, functions, and cell physiology of small RNAs remains important. The 4.5SI and 4.5SH small RNAs, which were among the first to be discovered and sequenced, share several features, i.e., they are both approximately 100 nt in size, are synthesized by RNA polymerase III, and are found only in rodents of several related families. Genes coding for these RNAs are evolutionarily related to short interspersed elements (SINEs). However, the two RNAs differ in nucleotide sequence, half-life in the cell, and the organization of their genes in the genome...
January 2017: Molekuliarnaia Biologiia
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