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https://www.readbyqxmd.com/read/28629778/posture-and-gaze-tracking-of-a-vertically-moving-target-reveals-age-related-constraints-in-visuo-motor-coupling
#1
H Sotirakis, A Kyvelidou, N Stergiou, V Hatzitaki
Previously we have demonstrated that the effect of aging on posture and gaze active tracking of a visual target moving in the horizontal direction is dependent on target's complexity. In this study, we asked whether a similar phenomenon is present when tracking a visual target moving with varying complexity in the vertical direction. Ten young (22.98±2.9years) and 10 older adults (72.45±4.72years) tracked for 120seconds, a visual target moving vertically by shifting their bodyweight in the anterior-posterior direction...
June 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28623770/energy-efficiency-increase-of-nqr-spectrometer-transmitter-at-pulse-resonance-excitation-with-noise-signals
#2
A Samila, V Khandozhko, L Politansky
The specific feature of NQR is expansion of spectral lines which is caused not only by dipole-dipole interaction of nuclei, but also by local field nonuniformity caused by the defects and deformation in crystal matrix. Considerable line expansion, which is typical of crystals, requires in pulsed NQR method the optimization of pulse shape and the reserve of transmitter power output. Parametric computer identification was used to study a dependence of parameters of the energy spectra of the output signal of pulsed NQR spectrometer transmitter on the duration of excitation pulses with sine and noise occupation...
June 8, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28620085/a-sine-insertion-in-atp1b2-in-belgian-shepherd-dogs-affected-by-spongy-degeneration-with-cerebellar-ataxia-sdca2
#3
Nico Mauri, Miriam Kleiter, Elisabeth Dietschi, Michael Leschnik, Sandra Högler, Michaela Wiedmer, Joëlle Dietrich, Diana Henke, Frank Steffen, Simone Schuller, Corinne Gurtner, Nadine Stokar-Regenscheit, Donal O'Toole, Thomas Bilzer, Christiane Herden, Anna Oevermann, Vidhya Jagannathan, Tosso Leeb
Spongy degeneration with cerebellar ataxia (SDCA) is a genetically heterogeneous neurodegenerative disorder with autosomal recessive inheritance in Malinois dogs, one of the four varieties of the Belgian Shepherd breed. Using a combined linkage and homozygosity mapping approach we identified a ~10.6 Mb critical interval on chromosome 5 in a Malinois family with four puppies affected by cerebellar dysfunction. Visual inspection of the 10.6 Mb interval in whole genome sequencing data from one affected puppy revealed a 227 bp SINE insertion into the ATP1B2 gene encoding the β2 subunit of the Na(+)/K(+)-ATPase holoenzyme (ATP1B2:c...
June 15, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28619818/antagonistic-regulation-of-the-second-mitotic-wave-by-eyes-absent-sine-oculis-and-combgap-coordinates-proliferation-and-specification-in-the-drosophila-retina
#4
Trevor L Davis, Ilaria Rebay
The transition from proliferation to specification is fundamental to the development of appropriately patterned tissues. In the developing Drosophila eye, Eyes absent (Eya) and Sine oculis (So) orchestrate the progression of progenitor cells from asynchronous cell division to G1 arrest and neuronal specification at the morphogenetic furrow. Here, we uncover a novel role for Eya and So in promoting cell cycle exit in the Second Mitotic Wave (SMW), a synchronized, terminal cell division that occurs several hours after passage of the furrow...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28619012/genetic-analysis-of-varicella-zoster-virus-in-the-aqueous-humor-in-uveitis-with-severe-hyphema
#5
Mayumi Hosogai, Yoko Nakatani, Kensuke Mimura, Shoji Kishi, Hideo Akiyama
BACKGROUND: Genetic variations have been identified in the genome of varicella-zoster virus (VZV) strains using vesicle fluid, varicella scabs and throat swab samples. We report a rare case of VZV-associated uveitis with severe hyphema, which was immediately diagnosed by polymerase chain reaction (PCR) using the aqueous humor, in which we were able to analyze the VZV genotype for the first time. CASE PRESENTATION: A 16-year-old Japanese boy was referred to our hospital with a 20-day history of unilateral anterior uveitis and 11-day history of hyphema...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28618801/relative-contributions-of-formants-to-the-intelligibility-of-sine-wave-sentences-in-mandarin-chinese
#6
Yiyuan Han, Fei Chen
Early sine-wave speech (SWS) studies showed that the first three formants contain sufficient intelligibility information. The present work assessed the relative perceptual contributions of the first three formants. Mandarin sentences were edited to generate two SWS conditions: removal of one of the first three formant trajectories, and preservation of only one formant trajectory. In addition, SWS synthesis was implemented in the absence of sine-wave amplitude modulation. The results consistently showed that the trajectory of the second formant contributed the most to intelligibility, and the effect of amplitude modulation was smaller than that of the formant number...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28616786/laryngotracheal-involvement-in-systemic-light-chain-amyloidosis
#7
Daniel T Ginat, Jefree Schulte, Louis Portugal, Nicole A Cipriani
Laryngotracheal amyloid deposition is an uncommon manifestation of systemic light chain amyloidosis. Diagnostic imaging, such as CT, is useful for suggesting the possibility of amyloidosis and delineating the extent of the lesions for surgical management; however, the diagnosis is confirmed with the histologic finding of amorphous eosinophilic material which stains positively for Congo red and may show apple green birefringence on polarization. These features are exemplified in this sine qua non radiology-pathology correlation article...
June 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28606835/identification-and-characterization-of-mobile-genetic-elements-lines-from-brassica-genome
#8
Faisal Nouroz, Shumaila Noreen, Muhammad Fiaz Khan, Shehzad Ahmed, J S Pat Heslop-Harrison
Among transposable elements (TEs), the LTR retrotransposons are abundant followed by non-LTR retrotransposons in plant genomes, the lateral being represented by LINEs and SINEs. Computational and molecular approaches were used for the characterization of Brassica LINEs, their diversity and phylogenetic relationships. Four autonomous and four non-autonomous LINE families were identified and characterized from Brassica. Most of the autonomous LINEs displayed two open reading frames, ORF1 and ORF2, where ORF1 is a gag protein domain, while ORF2 encodes endonuclease (EN) and a reverse transcriptase (RT)...
June 9, 2017: Gene
https://www.readbyqxmd.com/read/28601521/modulation-of-cadmium-induced-phytotoxicity-in-cabomba-caroliniana-by-urea-involves-photosynthetic-metabolism-and-antioxidant-status
#9
Wenmin Huang, Hui Shao, Sining Zhou, Qin Zhou, Wei Li, Wei Xing
Urea is a widespread organic pollutant, which can be a nitrogen source, playing different roles in the growth of submerged macrophytes depending on concentrations, while high cadmium (Cd) concentrations are often toxic to macrophytes. In order to evaluate the combined effect of urea and Cd on a submerged macrophyte, Cabomba caroliniana, the morphological and physiological responses of C. caroliniana in the presence of urea and Cd were studied. The results showed that high concentrations of urea (400mgL(-1)) and Cd (500µmolL(-1)) had negative effects on C...
June 8, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28601450/season-of-creation-is-associated-with-future-survival-fertility-and-milk-yield-of-holstein-cows
#10
P J Pinedo, A De Vries
Environmental influences during different stages of pregnancy can induce lifelong changes in the structure, physiology, and metabolism of the offspring. Our hypothesis was that season of creation (when the female conceived), associated with heat stress conditions at conception and during the initial stages of embryonic development, affects the lifetime performance and survival of the female after birth. The objective was to analyze the association between month of creation and subsequent survival, fertility, and milk yield in cows maintained on dairy farms in Florida, where the climate during the summer is hot and humid but winters are mild...
June 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28597008/effect-of-reduced-phosphoric-acid-pre-etching-times-%C3%A2-on-enamel-surface-characteristics-and-shear-fatigue-strength-using-universal-adhesives
#11
Akimasa Tsujimoto, Nicholas G Fischer, Wayne W Barkmeier, Andrew G Baruth, Toshiki Takamizawa, Mark A Latta, Masashi Miyazaki
PURPOSE: To examine the effect of reduced phosphoric acid pre-etching times on enamel fatigue bond strength of universal adhesives and surface characteristics by using atomic force microscopy (AFM). MATERIALS AND METHODS: Three universal adhesives were used in this study (Clearfil Universal Bond [C], G-Premio Bond [GP], Scotchbond Universal Adhesive [SU]). Four pre-etching groups were employed: enamel pre-etched with phosphoric acid and immediately rinsed with an air-water spray, and enamel pre-etched with phosphoric acid for 5, 10, or 15 s...
June 8, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28595628/six3-a-tumor-suppressor-inhibits-astrocytoma-tumorigenesis-by-transcriptional-repression-of-aurka-b
#12
Zhibin Yu, Yingnan Sun, Xiaoling She, Zeyou Wang, Shuai Chen, Zhiyong Deng, Yan Zhang, Qiang Liu, Qing Liu, Chunhua Zhao, Peiyao Li, Changhong Liu, Jianbo Feng, Haijuan Fu, Guiyuan Li, Minghua Wu
BACKGROUND: SIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our previous study showed that the SIX3 gene is hypermethylated, and its expression is decreased in astrocytoma, but the role of SIX3 remains unknown. METHODS: Chromatin-immunoprecipitation (ChIP) and luciferase reporter assay were used to confirm the binding of SIX3 to the promoter regions of aurora kinase A (AURKA) and aurora kinase B (AURKB)...
June 8, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28591710/selective-inhibitors-of-nuclear-export-sine-compounds-block-proliferation-and-migration-of-triple-negative-breast-cancer-cells-by-restoring-expression-of-arrdc3
#13
Young Hwa Soung, Trinayan Kashyap, Thalia Nguyen, Garima Yadav, Hua Chang, Yosef Landesman, Jun Chung
Arrestin-related domain-containing protein-3 (ARRDC3) is one of 6 mammalian arrestins, which suppresses metastasis by inducing degradation of phosphorylated β2-adrenergic receptor (β2 AR) and integrin β4 (ITG β4). Our previous studies demonstrated that expression of ARRDC3 is epigentically silenced in Triple Negative Breast Cancer (TNBC) cells, and the forced expression of ARRDC3 significantly reduced the invasive potential of TNBC cells. In the current study, we found that Selective Inhibitors of Nuclear Export (SINE) compounds (KPT-185 and selinexor (KPT-330)) restore ARRDC3 expression in TNBC cell lines (MDA-MB-231 and MDA-MB-468) at both the mRNA and protein level in a dose and time course dependent manner...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28587220/a-novel-real-time-path-servo-control-of-a-hardware-in-the-loop-for-a-large-stroke-asymmetric-rod-less-pneumatic-system-under-variable-loads
#14
Hao-Ting Lin
This project aims to develop a novel large stroke asymmetric pneumatic servo system of a hardware-in-the-loop for path tracking control under variable loads based on the MATLAB Simulink real-time system. High pressure compressed air provided by the air compressor is utilized for the pneumatic proportional servo valve to drive the large stroke asymmetric rod-less pneumatic actuator. Due to the pressure differences between two chambers, the pneumatic actuator will operate. The highly nonlinear mathematical models of the large stroke asymmetric pneumatic system were analyzed and developed...
June 4, 2017: Sensors
https://www.readbyqxmd.com/read/28584719/six4-promotes-metastasis-via-activation-of-the-pi3k-akt-pathway-in-colorectal-cancer
#15
Guodong Li, Fuqing Hu, Xuelai Luo, Junbo Hu, Yongdong Feng
BACKGROUND: Several studies report aberrant expression of sine oculis homeobox (SIX) homolog family members during cancer development and progression. SIX4 participates in organ development, such as myogenesis and neurogenesis. However, the expression and clinical implication of SIX4 in colorectal cancer (CRC) remains unclear. METHODS: The SIX4 expression levels in colorectal patients were assessed in nine different human cancer arrays and compared using patient survival data...
2017: PeerJ
https://www.readbyqxmd.com/read/28579633/rapid-and-accurate-c-v-measurements
#16
Ji-Hong Kim, Pragya R Shrestha, Jason P Campbell, Jason T Ryan, David Nminibapiel, Joseph J Kopanski, Kin P Cheung
We report a new technique for the rapid measurement of full capacitance-voltage (C-V) characteristic curves. The displacement current from a 100 MHz applied sine-wave, which swings from accumulation to strong inversion, is digitized directly using an oscilloscope from the metal-oxide-semiconductor (MOS) capacitor under test. A C-V curve can be constructed directly from this data but is severely distorted due to non-ideal behavior of real measurement systems. The key advance of this work is to extract the system response function using the same measurement set-up and a known MOS capacitor...
October 2016: IEEE Transactions on Electron Devices
https://www.readbyqxmd.com/read/28577881/gene-enriched-draft-genome-of-the-cattle-tick-rhipicephalus-microplus-assembly-by-the-hybrid-pacific-biosciences-illumina-approach-enabled-analysis-of-the-highly-repetitive-genome
#17
Roberto A Barrero, Felix D Guerrero, Michael Black, John McCooke, Brett Chapman, Faye Schilkey, Adalberto A Pérez de León, Robert J Miller, Sara Bruns, Jason Dobry, Galina Mikhaylenko, Keith Stormo, Callum Bell, Quanzhou Tao, Robert Bogden, Paula M Moolhuijzen, Adam Hunter, Matthew I Bellgard
The genome of the cattle tick Rhipicephalus microplus, an ectoparasite with global distribution, is estimated to be 7.1Gbp in length and consists of approximately 70% repetitive DNA. We report the draft assembly of a tick genome that utilized a hybrid sequencing and assembly approach to capture the repetitive fractions of the genome. Our hybrid approach produced an assembly consisting of 2.0Gbp represented in 195,170 scaffolds with a N50 of 60,284bp. The Rmi v2.0 assembly is 51.46% repetitive with a large fraction of unclassified repeats, short interspersed elements, long interspersed elements and long terminal repeats...
June 1, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28574734/the-recognizability-and-localizability-of-auditory-alarms-setting-global-medical-device-standards
#18
Judy Edworthy, Scott Reid, Siné McDougall, Jonathan Edworthy, Stephanie Hall, Danielle Bennett, James Khan, Ellen Pye
Objective Four sets of eight audible alarms matching the functions specified in IEC 60601-1-8 were designed using known principles from auditory cognition with the intention that they would be more recognizable and localizable than those currently specified in the standard. Background The audible alarms associated with IEC 60601-1-8, a global medical device standard, are known to be difficult to learn and retain, and there have been many calls to update them. There are known principles of design and cognition that might form the basis of more readily recognizable alarms...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28567127/path-loss-measurement-and-channel-modeling-with-muscular-tissue-characteristics
#19
Yu-Ping Qin, Shuang Zhang, Hai-Yan Liu, Yi-He Liu, You-Zhi Li, Xue Peng, Xiu Ma, Qi-Li Li, Xuan Huang
BACKGROUND: The galvanic coupling intra-body communication has low radiation and strong anti-interference ability, so it has many advantages in the wireless communication. METHOD: In order to analyze the effect of muscle tissue's characteristics upon the communication channel, we selected the muscle of pig buttock as the experimental sample, and used it to study the attenuation property with the galvanic coupling intra-body communication channel along the parallel direction and the transverse direction relative to the muscular fibre line as well as on the surface of destroyed muscular fibre; the study frequency ranges from 1kHz to 10MHz...
2017: Open Biomedical Engineering Journal
https://www.readbyqxmd.com/read/28566989/potential-effects-of-the-electronic-health-record-on-the-small-physician-practice-a-delphi-study
#20
Chad C Sines, Gerald R Griffin
The Health Information Technology for Economic and Clinical Health (HITECH) Act established the requirement of all medical practices to have certified electronic health records (EHRs). Some primary concerns that have been delaying implementation are issues of cost, revenue impact, and the effect on the patient encounter. Small physician practices (one to four physicians) account for 46 percent of all physicians. The purpose of this qualitative study using a modified Delphi research design was to examine the potential effect of the adoption of the EHR on revenue, unintended costs or savings, and changes in the patient encounter...
2017: Perspectives in Health Information Management
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