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Anne Burdess, Kevin Mani, Gustaf Tegler, Anders Wanhainen
Progress of aortic disease after stent graft treatment of aortic dissection includes the risk of Stent graft-Induced New Entry (SINE). In this paper we review the incidence and mechanisms thought to be responsible for retrograde ascending and distal SINE after TEVAR for Type B dissection, and examine potential techniques for treatment and prevention. Although the risk of proximal SINE is low, the fatality of this complication requires vigilance in patients who develop new onset symptoms in the early period after TEVAR treatment...
May 16, 2018: Journal of Cardiovascular Surgery
Paul A Constable, David Ngo
BACKGROUND: The standing potential of the eye exhibits a slow damped oscillation under light and dark conditions that continues for at least 80 minutes. However, our understanding of the relationship between the slow dark and light oscillation has not been previously studied. The aim of this study was to explore through regression analysis a model of these oscillations in order to establish if they may have the same underlying cellular generators. METHODS: Healthy participants undertook recordings of the standing potential using the electro-oculogram for 100 minutes...
May 20, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Chen Zhang, Sining Yun, Xue Li, Ziqi Wang, Hongfei Xu, Tingting Du
To improve the methane yield and digestate utilization of anaerobic digestion (AD), low-cost composited accelerants consisting of urea (0.2-0.5%), bentonite (0.5-0.8%), active carbon (0.6-0.9%), and plant ash (0.01-0.3%) were designed and tested in batch experiments. Total biogas yield (485.7-681.9 mL/g VS) and methane content (63.0-66.6%) were remarkably enhanced in AD systems by adding accelerants compared to those of control group (361.9 mL/g VS, 59.4%). Composited accelerant addition led to the highest methane yield (454...
May 11, 2018: Bioresource Technology
El-Sayed H Ibrahim, Jadranka Stojanovska, Azza Hassanein, Claire Duvernoy, Pierre Croisille, Rodica Pop-Busui, Scott D Swanson
Cardiac MRI tagging is a valuable technique for evaluating regional heart function. Currently, there are a number of different techniques for analyzing the tagged images. Specifically, k-space-based analysis techniques showed to be much faster than image-based techniques, where harmonic-phase (HARP) and sine-wave modeling (SinMod) stand as two famous techniques of the former group, which are frequently used in clinical studies. In this study, we compared HARP and SinMod and studied inter-observer variability between the two techniques for evaluating myocardial strain and apical-to-base torsion in numerical phantom, nine healthy controls, and thirty diabetic patients...
May 16, 2018: Magnetic Resonance Imaging
Kamal Z Zamli, Fakhrud Din, Bestoun S Ahmed, Miroslav Bures
The sine-cosine algorithm (SCA) is a new population-based meta-heuristic algorithm. In addition to exploiting sine and cosine functions to perform local and global searches (hence the name sine-cosine), the SCA introduces several random and adaptive parameters to facilitate the search process. Although it shows promising results, the search process of the SCA is vulnerable to local minima/maxima due to the adoption of a fixed switch probability and the bounded magnitude of the sine and cosine functions (from -1 to 1)...
2018: PloS One
Pavol Skubák, Demet Araç, Matthew W Bowler, Ana R Correia, Andre Hoelz, Sine Larsen, Gordon A Leonard, Andrew A McCarthy, Sean McSweeney, Christoph Mueller-Dieckmann, Harm Otten, Gabriel Salzman, Navraj S Pannu
Determining macromolecular structures from X-ray data with resolution worse than 3 Å remains a challenge. Even if a related starting model is available, its incompleteness or its bias together with a low observation-to-parameter ratio can render the process unsuccessful or very time-consuming. Yet, many biologically important macromolecules, especially large macromolecular assemblies, membrane proteins and receptors, tend to provide crystals that diffract to low resolution. A new algorithm to tackle this problem is presented that uses a multivariate function to simultaneously exploit information from both an initial partial model and low-resolution single-wavelength anomalous diffraction data...
March 1, 2018: IUCrJ
Yuangen Yao, Jun Ma
Based on the FitzHugh-Nagumo (FHN) neuron model subjected to sine-Wiener (SW) noise, impacts of SW noise on weak periodic signal detection are investigated by calculating response measure Q for characterizing synchronization between the input signal and the output temporal activities of the neuron. It is numerically demonstrated that the response measure Q can achieve the optimal value under appropriate and moderate intensity or correlation time of SW noise, suggesting the occurrence of SW-noise-induced stochastic resonance...
June 2018: Cognitive Neurodynamics
Zhenhui Zhang, Yujiao Shi, Sihua Yang, Da Xing
We have developed a second harmonic photoacoustic microscopy (SH-PAM) for subdiffraction-limited imaging based on nonlinear thermal diffusion. When a sine-modulated Gaussian temperature field is introduced by a laser beam, the temperature dependence of the thermal diffusivity induces a nonlinear photoacoustic (PA) effect and thus results in the production of second harmonic PA signals. We demonstrate through both simulation and experiment that the second harmonic PA images can be reconstructed with a lateral resolution exceeding that of conventional optical resolution PA microscopy...
May 15, 2018: Optics Letters
Xiaoli Liu, Nan Zhang, Hong Liang, Zhengbo Zhang, Deyu Li, Weidong Wang
The forced oscillation technique (FOT) is an active pulmonary function measurement technique that was applied to identify the mechanical properties of the respiratory system using external excitation signals. FOT commonly includes single frequency sine, pseudorandom and periodic impulse excitation signals. Aiming at preventing the time-domain amplitude overshoot that might exist in the acquisition of combined multi sinusoidal pseudorandom signals, this paper studied the phase optimization of pseudorandom signals...
October 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Sofia Lavrenteva, Ikuya Murakami
In the retinal image of the natural world, edges and shapes can be defined by first-order attributes, such as luminance, and second-order attributes, such as contrast and texture. Previous studies have suggested that, in the human visual system, these attributes are initially detected separately and integrated later. Thus, comparing the strength of different geometrical optical illusions in stimuli, in which different elements are defined by the same or different attributes, is helpful to investigate at which stage the underlying mechanism of the illusion is located...
May 11, 2018: Vision Research
Elvira Sondo, Federico Falchi, Emanuela Caci, Loretta Ferrera, Elisa Giacomini, Emanuela Pesce, Valeria Tomati, Sine Mandrup Bertozzi, Luca Goldoni, Andrea Armirotti, Roberto Ravazzolo, Andrea Cavalli, Nicoletta Pedemonte
In cystic fibrosis (CF), deletion of phenylalanine 508 (F508del) in the CFTR channel is associated with misfolding and premature degradation of the mutant protein. Among the known proteins associated with F508del-CFTR processing, the ubiquitin ligase RNF5/RMA1 is particularly interesting. We previously demonstrated that genetic suppression of RNF5 in vivo leads to an attenuation of intestinal pathological phenotypes in CF mice, validating the relevance of RNF5 as a drug target for CF. Here, we used a computational approach, based on ligand docking and virtual screening, to discover inh-02, a drug-like small molecule that inhibits RNF5...
April 26, 2018: Cell Chemical Biology
A Őze, A Puszta, P Buzás, P Kóbor, G Braunitzer, A Nagy
Flashing light stimulation is often used to investigate the visual system. However, the magnitude of the effect of this stimulus on the various subcortical pathways is not well investigated. The signals of conscious vision are conveyed by the magnocellular, parvocellular and koniocellular pathways. Parvocellular and koniocellular pathways (or more precisely, the L-M opponent and S-cone isolating channels) can be accessed by isoluminant red-green (L-M) and S-cone isolating stimuli, respectively. The main goal of the present study was to explore how costimulation with strong white extrafoveal light flashes alters the perception of stimuli specific to these pathways...
May 8, 2018: Neuroscience Letters
Jian Wu, Qiao Wang, Wei Dai, Wei Wang, Ming Yue, Jinke Wang
Nuclear factor κB (NF-κB) is a DNA-binding transcription factor. Characterizing its genomic binding sites is crucial for understanding its gene regulatory function and mechanism in cells. This study characterized the binding sites of NF-κB RelA/p65 in the tumor neurosis factor-α (TNFα) stimulated HeLa cells by a precise chromatin immunoprecipitation-sequencing (ChIP-seq). The results revealed that NF-κB binds nontraditional motifs (nt-motifs) containing conserved GGAA quadruplet. Moreover, nt-motifs mainly distribute in the peaks nearby centromeres that contain a larger number of repetitive elements such as satellite, simple repeats and short interspersed nuclear elements (SINEs)...
April 13, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
Tilo Kölbel, Nikolaos Tsilimparis, Kevin Mani, Fiona Rohlffs, Sabine Wipper, E Sebastian Debus, Yskert von Kodolitsch, Anders Wanhainen
PURPOSE: To describe a novel modification technique to lower the distal radial force of a thoracic stent-graft so as to avert stent-graft-induced new entry tears (SINE) in the fragile aorta of patients with genetic aortic disease and aortic dissection. TECHNIQUE: A commercially available thoracic stent-graft is partially deployed on a back table. The most distal Z-stent is removed, the distal fabric is marked by vascular clips, and the modified stent-graft is reloaded and deployed in the true lumen of an aortic dissection...
May 1, 2018: Journal of Endovascular Therapy
Chang Liu, Xueqin Ran, Xi Niu, Sheng Li, Jiafu Wang, Qin Zhang
The aim of the study was to investigate the SINE polymorphism in Xiang, Kele, Qianbei black, Jiangkouluobo, Large White, and Duroc pig breeds. The PCR based detection method was conducted to identify the short interspersed nuclear element (SINE) polymorphism in the PDIA4 gene. There were greater frequencies of the SINE-/- genotypes in Xiang pigs (55.9%) as compared with other pig breed groups. There was an association between this 275 bp SINE polymorphism and litter size (P = 0.003). The homozygous SINE+/+ genotype of the PDIA4 gene had a 1...
April 26, 2018: Animal Reproduction Science
Qinghua Yan, Sining Chen, Cheng Zhang, Dermot O'Hare, Qiang Wang
We report a novel NH3 -SCR catalyst Cu0.5 Mg1.5 Mn0.5 Al0.5 Ox synthesized from layered double hydroxides with superior activity in a wide temperature range and improved SO2 and H2 O resistance comparing to conventional doped Mn/γ-Al2 O3 . This catalyst results in a high NOx removal efficiency of 87.0-96.6% in the low temperature range of 100-250 °C, much better than Mn/γ-Al2 O3 (35.0-67.2%). Besides, it exhibits significant resistance to SO2 and H2 O due to the existence of Cu and Mg. The promoting effects of Cu and Mg are thoroughly investigated using various physico-chemical techniques...
April 26, 2018: Journal of Colloid and Interface Science
Sining Han, Na Jiang, Qingyang Lv, Yumin Kan, Jianjun Hao, Jianqiang Li, Laixin Luo
Clavibacter michiganensis subsp. michiganensis (Cmm) is a seed-borne pathogen that causes bacterial canker disease of tomato. Cmm is typically detected in tomato seeds using quantitative real-time polymerase chain reaction (qPCR) combined with culture-based isolation. The viable but nonculturable (VBNC) state of Cmm may result in the underestimation or false negative detection of the pathogen. In the present study, propidium monoazide (PMA) and its improved structure PMAxx were used to pretreat Cmm prior to DNA extraction, followed by qPCR...
2018: PloS One
Sanjay Prakash, Bansi Adroja
Hemicrania continua (HC) is an indomethacin responsive primary chronic headache disorder which is currently classified as a subtype of trigeminal autonomic cephalalgias (TACs). It is not very uncommon. There are >1000 cases of HC in the literature, and it constitutes 1.7% of total headache in the clinic settings. Misdiagnosis for HC is very common at all clinical settings. A diagnosis of HC is missed even by neurologists and headache specialists. It is characterized by a continuous strictly unilateral headache with superimposed exacerbations...
April 2018: Annals of Indian Academy of Neurology
Masoud Arablu, Sajad Kafashi, Stuart T Smith
A novel Radio-Frequency Frequency-Modulated (RF-FM) signal generation method is introduced and a prototype circuit developed to evaluate its functionality and performance. The RF-FM signal generator uses a modulated, voltage-controlled time delay to correspondingly modulate the phase of a 10 MHz sinusoidal reference signal. This modulated reference signal is, in turn, used to clock a Direct Digital Synthesizer (DDS) circuit resulting in an FM signal at its output. The modulating signal that is input to the voltage-controlled time delay circuit is generated by another DDS that is synchronously clocked by the same 10 MHz sine wave signal before modulation...
April 2018: Review of Scientific Instruments
Kenneth J Leedle, Dylan S Black, Yu Miao, Karel E Urbanek, Andrew Ceballos, Huiyang Deng, James S Harris, Olav Solgaard, Robert L Byer
We present the demonstration of phase-dependent laser acceleration and deflection of electrons using a symmetrically driven silicon dual pillar grating structure. We show that exciting an evanescent inverse Smith-Purcell mode on each side of a dual pillar grating can produce hyperbolic cosine acceleration and hyperbolic sine deflection modes, depending on the relative excitation phase of each side. Our devices accelerate sub-relativistic 99.0 keV kinetic energy electrons by 3.0 keV over a 15 μm distance with accelerating gradients of 200 MeV/m with 40 nJ, 300 fs, 1940 nm pulses from an optical parametric amplifier...
May 1, 2018: Optics Letters
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