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Jiannan Dai, Lei Xing, Haibo Jia, Yinchun Zhu, Shaotao Zhang, Sining Hu, Lin Lin, Lijia Ma, Huimin Liu, Maoen Xu, Xuefeng Ren, Huai Yu, Lulu Li, Yanan Zou, Shaosong Zhang, Gary S Mintz, Jingbo Hou, Bo Yu
Aims: Plaque erosion is a significant substrate of acute coronary thrombosis. This study sought to determine in vivo predictors of plaque erosion in patients with ST-segment elevation myocardial infarction (STEMI). Methods and results: A prospective series of 822 STEMI patients underwent pre-intervention optical coherence tomography. Using established diagnostic criteria, 209 had plaque erosion (25.4%) and 564 had plaque rupture (68.6%). Plaque erosion was more frequent in women <50 years when compared with those ≥50 years of age (P = 0...
March 13, 2018: European Heart Journal
Hilary C Archbold, Kasey L Jackson, Ayush Arora, Kaitlin Weskamp, Elizabeth M-H Tank, Xingli Li, Roberto Miguez, Robert D Dayton, Sharon Tamir, Ronald L Klein, Sami J Barmada
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative disorders marked in most cases by the nuclear exclusion and cytoplasmic deposition of the RNA binding protein TDP43. We previously demonstrated that ALS-associated mutant TDP43 accumulates within the cytoplasm, and that TDP43 mislocalization predicts neurodegeneration. Here, we sought to prevent neurodegeneration in ALS/FTD models using selective inhibitor of nuclear export (SINE) compounds that target exportin-1 (XPO1)...
March 15, 2018: Scientific Reports
Li Chen, Nathchar Naowarojna, Heng Song, Shu Wang, Jianyun Wang, Zixin Deng, Changming Zhao, Pinghua Liu
Ovothiol is a histidine thiol derivative. The biosynthesis of ovothiol involves an extremely efficient trans-sulfuration strategy. The non-heme iron enzyme OvoA catalyzed oxidative coupling be-tween cysteine and histidine is one of the key steps. Besides catalyzing the oxidative coupling between cysteine and histidine, OvoA also catalyzes the oxi-dation of cysteine to cysteine sulfinic acid (cysteine dioxygenase activity). Thus far, very little mecha-nistic information is available for OvoA-catalysis. In this report, we measured the kinetic isotope effect (KIE) in OvoA-catalysis using the isotopically sensitive branching method...
March 15, 2018: Journal of the American Chemical Society
Sellappan Selvaraju, Sivashanmugam Parthipan, Lakshminarayana Somashekar, B Krishnan Binsila, Atul P Kolte, Arunachalam Arangasamy, Janivara Parameshwaraiah Ravindra, Stephen A Krawetz
With artificial insemination (AI) and other precision dependent assisted reproductive technologies (ART) being followed in large scale in human and animal reproduction, assessing semen quality and fertilizability is under continuous scrutiny. Various tests have been developed to predict semen quality, but so far no single, highly reliable test is available. In this regard, transcriptomic profiling of spermatozoa assumes significance as it carries the information about spermatogenesis, sperm function, and paternal roles in post-fertilization events...
March 14, 2018: Systems Biology in Reproductive Medicine
Almin I Lalani, Sining Zhu, Samantha Gokhale, Juan Jin, Ping Xie
Purpose of Review: This review presents an overview of the current knowledge of TRAF molecules in inflammation with an emphasis on available human evidence and direct in vivo evidence of mouse models that demonstrate the contribution of TRAF molecules in the pathogenesis of inflammatory diseases. Recent Findings: The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic proteins was initially identified as signaling adaptors that bind directly to the intracellular domains of receptors of the TNF-R superfamily...
February 2018: Current Pharmacology Reports
Scinob Kuroki, Shin'ya Nishida
When we touch an object, the skin copies its surface shape/texture, and this deformation pattern shifts according to the objects movement. This shift pattern directly encodes spatio-temporal "motion" information of the event, and has been detected in other modalities (e.g., inter-aural time differences for audition and first-order motion for vision). Since previous studies suggested that mechanoreceptor-afferent channels with small receptive field and slow temporal characteristics contribute to tactile motion perception, we tried to tap the spatio-temporal processor using low-frequency sine-waves as primitive probes in our previous study...
March 9, 2018: Scientific Reports
Andrea Meoni, Antonella D'Alessandro, Austin Downey, Enrique García-Macías, Marco Rallini, A Luigi Materazzi, Luigi Torre, Simon Laflamme, Rafael Castro-Triguero, Filippo Ubertini
The availability of new self-sensing cement-based strain sensors allows the development of dense sensor networks for Structural Health Monitoring (SHM) of reinforced concrete structures. These sensors are fabricated by doping cement-matrix mterials with conductive fillers, such as Multi Walled Carbon Nanotubes (MWCNTs), and can be embedded into structural elements made of reinforced concrete prior to casting. The strain sensing principle is based on the multifunctional composites outputting a measurable change in their electrical properties when subjected to a deformation...
March 9, 2018: Sensors
Alejandra Consejo, Jos J Rozema
PURPOSE: To assess the correlation between the scleral shape and corneal astigmatism. METHODS: Twenty-two participants (11 nonastigmatic and 11 astigmatic) aged from 19 to 36 years and with no previous ocular surgeries were included in this study. Three-dimensional (3D) corneoscleral maps from both eyes (44 eyes) were acquired using a corneoscleral topographer (Eye Surface Profiler). Each 3D map was split into 13 concentric annuli, each 0.5-mm wide, starting at 1...
March 6, 2018: Cornea
Juan Liu, Kun-Shan Zhang, Bin Hu, Si-Guang Li, Qing Li, Yu-Ping Luo, Yang Wang, Zhi-Feng Deng
Although extensive studies have identified large number of microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) in ischemic stroke, the RNA regulation network response to focal ischemia remains poorly understood. In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes during focal ischemia induced by transient middle cerebral artery occlusion. A set of 1924 novel lncRNAs were identified and may involve brain injury and DNA repair as revealed by coexpression network analysis...
2018: BioMed Research International
Preeti Verma, Soma Sarkar, Poonam Singh, Ramesh C Dhiman
Background & objectives: Uncertainty often arises in differentiating seasonal variation from outbreaks of malaria. The present study was aimed to generalize the theoretical structure of sine curve for detecting an outbreak so that a tool for early warning of malaria may be developed. Methods: A 'case/mean-ratio scale' system was devised for labelling the outbreak in respect of two diverse districts of Assam and Rajasthan. A curve-based method of analysis was developed for determining outbreak and using the properties of sine curve...
November 2017: Indian Journal of Medical Research
Anne-Sophie Homøe, Sine Berntsen, Michael Lynge Pedersen
For decades the spread of sexually transmitted infections (STIs) has been a health concern in Greenland, especially within the age group of 15-34 year olds. However, no overview exists of the potential differences in regional incidence and management of STIs. This study investigates the age, gender and region specific diagnostic activity and incidence of gonorrhoea in Greenland in 2015. The study design was an observational cross sectional register study with inclusion of patients tested for gonorrhoea in 2015...
December 2018: International Journal of Circumpolar Health
Sadollah Ebrahimi
In this study, the lubricity of perfect and defective graphene on the gold substrate (Au (111)) has been investigated by using molecular dynamics simulations. The influence of surface morphology as well as the Stone-Wales (SW) defects concentration on the friction of graphene on the gold surface is explored. The SW defects in the range of 0-2.55% are randomly distributed into the graphene. Furthermore, the self-affine fractal method is employed to generate realistic rough surfaces. The effect of the external force, FE , in the range of 0...
March 2, 2018: Journal of Molecular Modeling
Dawei Wei, Sayed Haidar Abbas Raza, Jiupan Zhang, Linsheng Gui, Siddiq Ur Rahman, Rajwali Khan, Seyed Mahdi Hosseini, Hubdar Ali Kaleri, Linsen Zan
The sine oculis homeobox homolog 4 (SIX4) gene belongs to the SIX gene family, which plays a critical role in muscle regeneration and early stages of ontogeny. This study aimed to detect promoter variations of bovine SIX4 genes in Qinchuan cattle, and to evaluate the effect of transcription regulations and body measurement traits. Quantitative real-time PCR (qPCR) results showed that the mRNA expression levels of SIX4 gene were found significantly highest in longissimus thoracis tissue and individual before attaining the stage of physiological maturity...
February 26, 2018: Gene
Ralph G DeVoe
The Allan variance of signal and reference frequencies is measured by a least-square fit of the output of two analog-to-digital converters to ideal sine waves. The difference in the fit phase of the two channels generates the timing data needed for the Allan variance. The fits are performed at the signal frequency (≈10 MHz) without the use of heterodyning. Experimental data from a modified digital oscilloscope yield a residual Allan deviation of 3 × 10-13 /τ, where τ is the observation time in s. This corresponds to a standard deviation in time of <300 fs or 20 μrad in phase...
February 2018: Review of Scientific Instruments
Fudong Zhang, Chen Chen, Jie Liu, Zhihong Wang
This study focuses on improving the accuracy of a grating monochromator on the basis of the grating diffraction equation in combination with an analysis of the mechanical transmission relationship between the grating, the sine bar, and the screw of the scanning mechanism. First, the relationship between the mechanical error in the monochromator with the sine drive and the wavelength error is analyzed. Second, a mathematical model of the wavelength error and mechanical error is developed, and an accurate wavelength calibration method based on the sine bar's length adjustment and error compensation is proposed...
February 2018: Review of Scientific Instruments
Andreas Spiegelberg, Matthias Krause, Juergen Meixensberger, Burkhardt Seifert, Vartan Kurtcuoglu
OBJECTIVE: We aimed to test whether there is an association of slow vasogenic wave (SVW) occurrence with positive response to external lumbar drainage (ELD) and ventriculoperitoneal shunting and to design a method for the recognition and quantification of SVWs in the intracranial pressure (ICP) signal. MATERIALS AND METHODS: We constructed SVW templates using normalized sine waves. We calculated the cross-correlation between the respective SVW template and the ICP signal...
2018: Acta Neurochirurgica. Supplement
Andrew J A James, Robert M Konik, Philippe Lecheminant, Neil J Robinson, Alexei M Tsvelik
We review two important non-perturbative approaches for extracting the physics of low-dimensional strongly correlated quantum systems. Firstly, we start by providing a comprehensive review of non-Abelian bosonization. This includes an introduction to the basic elements of conformal field theory as applied to systems with a current algebra, and we orient the reader by presenting a number of applications of non-Abelian bosonization to models with large symmetries. We then tie this technique into recent advances in the ability of cold atomic systems to realize complex symmetries...
February 26, 2018: Reports on Progress in Physics
Sine Kirkegaard, Ditte Andersen
The concept of co-production suggests a collaborative production of public welfare services, across boundaries of participant categories, for example professionals, service users, peer-workers and volunteers. While co-production has been embraced in most European countries, the way in which it is translated into everyday practice remains understudied. Drawing on ethnographic data from Danish community mental health services, we attempt to fill this gap by critically investigating how participants interact in an organisational set-up with blurred boundaries between participant categories...
February 25, 2018: Sociology of Health & Illness
Qiuxia Cui, Deguang Kong, Zhihua Li, Philemon Ahiable, Kun Wang, Kongming Wu, Gaosong Wu
INTRODUCTION: Male breast cancer (MBC) is rare and little is known about its biological behavior. In this study we described clinical characteristics and prognosis of MBC and evaluated roles of different factors between MBC and female breast cancer (FBC). PATIENTS AND METHODS: We retrospectively reviewed 42 MBC patients matched with 84 consecutive FBC patients with similar year, age, tumor, node, metastases (TNM) stage, and estrogen receptor (ER) expression from 2003 to 2016...
February 2, 2018: Clinical Breast Cancer
Sine Knorr, Svend Juul, Birgitte Bytoft, Zuzana Lohse, Tine D Clausen, Rikke B Jensen, Peter Damm, Henning Beck-Nielsen, Elisabeth R Mathiesen, Dorte M Jensen, Claus H Gravholt
AIMS/HYPOTHESIS: The aims of this study were to examine long-term mortality and morbidity rates in mothers with type 1 diabetes, both overall and according to the level of albuminuria prior to pregnancy, the presence of hypertension, pre-eclampsia and periconceptional HbA1c . METHODS: This study was a part of the EPICOM (Environmental Versus Genetic and Epigenetic Influences on Growth, Metabolism and Cognitive Function in Offspring of Mothers with Type 1 Diabetes) study, which is a prospective follow-up study focusing on pregnancies complicated by maternal type 1 diabetes...
February 24, 2018: Diabetologia
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