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https://www.readbyqxmd.com/read/27906498/st3gal6-mediates-the-effect-of-mir-26a-on-cell-growth-migration-and-invasion-in-hepatocellular-carcinoma-via-the-akt-mtor-pathway
#1
Mingming Sun, Xuzi Zhao, Leilei Liang, Xufeng Pan, Hao Lv, Yongfu Zhao
Aberrant sialylation profiles on the cell surface have been recognized for their potential diagnostic value in identifying the regulation of tumor properties in several cancers, including hepatocellular carcinoma (HCC). Recently, increasing evidence has suggested that the deregulation of microRNA (miRNA) is a common feature in human cancers. In this study, we found obvious up-regulation of ST3GAL6 both in HCC cell lines and in tissue samples. The altered expression of ST3GAL6 was found to correlate with cell proliferation, migration and invasion ability in HCC...
December 1, 2016: Cancer Science
https://www.readbyqxmd.com/read/27906496/aerobic-expression-of-vitreoscilla-hemoglobin-improves-the-growth-performance-of-cho-k1-cells
#2
Mariana Juárez, Claudia H González-De la Rosa, Elisa Memún, Juan-Carlos Sigala, Alvaro R Lara
Inefficient carbon metabolism is a relevant issue during the culture of mammalian cells for the production of biopharmaceuticals. Therefore, cell engineering strategies to improve the metabolic and growth performance of cell lines are needed. The expression of Vitreoscilla stercoraria hemoglobin (VHb) has been shown to significantly reduce overflow metabolism and improve the aerobic growth of bacteria. However, the effects of VHb on mammalian cells have been rarely studied. Here, the impact of VHb on growth and lactate accumulation during CHO-K1 cell culture was investigated...
December 1, 2016: Biotechnology Journal
https://www.readbyqxmd.com/read/27906490/exhaled-nitric-oxide-in-the-diagnosis-of-asthma-in-adults-a-systematic-review
#3
Sue E Harnan, Munira Essat, Tim Gomersall, Paul Tappenden, Ian Pavord, Mark Everard, Rod Lawson
OBJECTIVES: To identify and synthesise evidence on the diagnostic accuracy of FE NO for asthma in adults. MATERIALS AND METHODS: Systematic searches (nine key biomedical databases and trial registers) were carried out to November 2014. Records were included if they: recruited patients with the symptoms of asthma; used a single set of inclusion criteria; measured FE NO50 in accordance with American Thoracic Society guidelines, 2005 (off-line excluded); reported/allowed calculation of true positive, true negative, false positive and false negative patients as classified against any reference standard...
December 1, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27906472/long-term-clinical-impact-and-cost-effectiveness-of-obeticholic-acid-for-the-treatment-of-primary-biliary-cholangitis
#4
Sumeyye Samur, Matthew Klebanoff, Reiner Banken, Daniel S Pratt, Rick Chapman, Daniel A Ollendorf, Anne M Loos, Kathleen Corey, Chin Hur, Jagpreet Chhatwal
: Primary biliary cholangitis (PBC) is a chronic, progressive autoimmune liver disease that mainly affects middle-aged women. Obeticholic acid (OCA), which was recently approved by the Food and Drug Administration for PBC treatment, has demonstrated positive effects on biochemical markers of liver function. Our objective was to evaluate the long-term clinical impact and cost-effectiveness of OCA as a second-line treatment for PBC in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA...
November 7, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27906435/down-regulation-of-microrna-143-is-associated-with-colorectal-cancer-progression
#5
J-W Bai, H-Z Xue, C Zhang
OBJECTIVE: Colorectal cancer (CRC) is one of the most prevalent carcinomas worldwide. Tumor metastasis and recurrence are leading causes of CRC-related deaths. Given the role of microRNA (miRNA) in CRC invasion and metastasis, we explored the association between miRNA-143 expression and clinicopathologic characteristics in CRC, as well as the effects of miRNA-143 on CRC cell invasion in vitro. MATERIALS AND METHODS: Quantitative real-time PCR was conducted to assess the expression of miR-143 in tissue specimens and cell lines...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906433/microrna-185-5p-modulates-chemosensitivity-of-human-non-small-cell-lung-cancer-to-cisplatin-via-targeting-abcc1
#6
K Pei, J-J Zhu, C-E Wang, Q-L Xie, J-Y Guo
OBJECTIVE: MicroRNA-185-5p (miR-185-5p) dysregulation is found in various human cancers. Our purpose is to investigate the association of miR-185-5p expression with the sensitivity of non-small cell lung cancer (NSCLC) to cisplatin. MATERIALS AND METHODS: Real-time PCR or Western blot assay was performed to detect the expression of mature miR-185-5p and ATP-binding cassette, subfamily C, member 1 (ABCC1) protein. Cell lines with abnormal expression of miR-185-5p were generated using miR-185-5p inhibitor and mimics...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906420/the-effect-of-low-dosage-of-procaine-on-lung-cancer-cell-proliferation
#7
X-W Ma, Y Li, X-C Han, Q-Z Xin
OBJECTIVE: Non-small cell lung cancer (NSCLC) is the most common type of human lung cancer leading cause of cancer death worldwide. However, first-line drugs such as gefitinib and erlotinib showed great drug resistance in the clinical. MATERIALS AND METHODS: The cell proliferation was evaluated by MTT assay; gene expression was detected by qPCR assay. The protein expression was analyzed by Western blotting. RESULTS: Our results showed that in mouse models of lung cancer by A549 or NCI-H1975 xenograft, the local anesthetic drug Procaine (PCA) with 50 mg/kg specifically attenuated tumors compared with the vehicle-treated group...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27906367/cultivation-of-lemon-fields
#8
Sushanta Kumar Pal, P Senthilkumaran
The sign rule requires that adjacent singularities on a contour have opposite signs and hence cultivation of lemon only fields poses problem as all lemons have positive index. In this paper we show that the interference of three linearly polarized plane waves can create regions of ellipse and vector fields in 2-dimensions (2D) in which a lemon lattice is interlaced in a V-point lattice. The lemons appear at intensity maxima of the lattice structure while the V-points take care of index conservation by sitting at intensity minima...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906345/grating-coupling-based-excitation-of-bloch-surface-waves-for-lab-on-fiber-optrodes
#9
Michele Scaravilli, Giuseppe Castaldi, Andrea Cusano, Vincenzo Galdi
In this paper, we investigate the possibility to excite Bloch surface waves (BSWs) on the tip of single-mode optical fibers. Within this framework, after exploring an idealized, proof-of-principle grating-coupling-based scheme for on-tip excitation of BSWs, we focus on an alternative configuration that is more robust with respect to fabrication-related non-idealities. Subsequently, with a view towards label-free chemical and biological sensing, we present a specific design aimed at enhancing the sensitivity (in terms of wavelength shift) of the arising resonance with respect to changes in the refractive properties of the surrounding environment...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906343/single-distance-phase-retrieval-algorithm-for-bragg-magnifier-microscope
#10
Stanislav Hrivňak, Jozef Uličný, Ladislav Mikeš, Angelica Cecilia, Elias Hamann, Tilo Baumbach, Libor Švéda, Zdenko Zápražný, Dušan Korytár, Eva Gimenez-Navarro, Ulrich H Wagner, Christoph Rau, Hartmut Greven, Patrik Vagovič
We present an improved, single-distance phase retrieval algorithm applicable for holographic X-ray imaging of biological objects for an in-line germanium Bragg Magnifier Microscope (BMM). The proposed algorithm takes advantage of a modified shrink-wrap algorithm for phase objects, robust unwrapping algorithm as well as other reasonable constraints applied to the wavefield at the object and the detector plane. The performance of the algorithm is analyzed on phantom objects and the results are shown and discussed...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906339/shaping-of-ultraviolet-femtosecond-laser-pulses-by-fourier-domain-harmonic-generation
#11
E Hertz, F Billard, G Karras, P Béjot, B Lavorel, O Faucher
We present a method to finely tailor ultraviolet femtosecond laser pulses using a pulse shaper with ability in the infrared/visible spectral range. We have developed to that end a frequency doubling module in which the up-conversion mechanism is carried out in the Fourier plane of a 4 f -line. The pulse shaper is used to imprint a spectral phase and/or amplitude onto the fundamental pulse. The shaped pulse is then frequency doubled through the module which transfers the applied spectral shaping to the second harmonic field in a predictable manner...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906336/in-line-optofluidic-refractive-index-sensing-in-a-side-channel-photonic-crystal-fiber
#12
Nan Zhang, Georges Humbert, Zhifang Wu, Kaiwei Li, Perry Ping Shum, Nancy Meng Ying Zhang, Ying Cui, Jean-Louis Auguste, Xuan Quyen Dinh, Lei Wei
An in-line optofluidic refractive index (RI) sensing platform is constructed by splicing a side-channel photonic crystal fiber (SC-PCF) with side-polished single mode fibers. A long-period grating (LPG) combined with an intermodal interference between LP<sub>01</sub> and LP<sub>11</sub> core modes is used for sensing the RI of the liquid in the side channel. The resonant dip shows a nonlinear wavelength shift with increasing RI over the measured range from 1.3330 to 1.3961. The RI response of this sensing platform for a low RI range of 1...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906324/energy-level-systems-and-transitions-of-ho-luag-laser-resonantly-pumped-by-a-narrow-line-width-tm-fiber-laser
#13
Hao Chen, Ting Zhao, Hao Yang, Le Zhang, Tianyuan Zhou, Dingyuan Tang, Chingping Wong, Yung-Fu Chen, Deyuan Shen
We presented a Ho:LuAG ceramic laser in-band pumped by a narrow emission line-width Tm fiber laser at 1907 nm. All of potential transitions between 5I7 and 5I8 manifold were discussed to form the Ho's in-band-pump energy level systems, which were not described in details earlier. For the emission band centered at ~2095 nm, both laser absorption and emission transition separately consisted of two groups were first analyzed and observed. Using output couplers (OCs) with different transmittances (T = 6, 10 and 20%), the similar ~0...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906296/numerical-modeling-of-fiber-specklegram-sensors-by-using-finite-element-method-fem
#14
V H Arístizabal, F J Vélez, E Rueda, N D Gómez, J A Gómez
Although experimental advances in the implementation and characterization of fiber speckle sensor have been reported, a suitable model to interpret the speckle-pattern variation under perturbation is desirable but very challenging to be developed due to the various factors influencing the speckle pattern. In this work, a new methodology based on the finite element method (FEM) for modeling and optimizing fiber specklegram sensors (FSSs) is proposed. The numerical method allows computational visualization and quantification, in near field, of changes of a step multi-mode fiber (SMMF) specklegram, due to the application of a uniformly distributed force line (UDFL)...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906275/near-core-structure-of-a-propagating-optical-vortex
#15
Priyanka Lochab, P Senthilkumaran, Kedar Khare
We study the propagation of a charge-1 vortex beam using the angular spectrum method. While vortex beams are commonly assumed to have a helical wavefront, it is well known that the phase of the vortex in the near-core region varies arbitrarily quickly. In order to explain the wavefront behavior in the near-core region, ideas such as evanescent fields or superoscillatory functions have been used before. Our study using the angular spectrum method can inherently take into account the propagating as well as evanescent spatial frequencies and is able to provide the detailed wavefront structure as the vortex wavefront evolves...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27906234/generation-of-spectral-clusters-in-a-mixture-of-noble-and-raman-active-gases
#16
Pooria Hosseini, Amir Abdolvand, Philip St J Russell
We report a novel scheme for the generation of dense clusters of Raman sidebands. The scheme uses a broadband-guiding hollow-core photonic crystal fiber (HC-PCF) filled with a mixture of H<sub>2</sub>, D<sub>2</sub>, and Xe for efficient interaction between the gas mixture and a green laser pump pulse (532 nm, 1 ns) of only 5 μJ of energy. This results in the generation from noise of more than 135 rovibrational Raman sidebands covering the visible spectral region with an average spacing of only 2...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906212/influence-of-co-sub-2-sub-pressure-on-the-emission-spectra-and-plasma-parameters-in-underwater-laser-induced-breakdown-spectroscopy
#17
Christian L Goueguel, Dustin L McIntyre, Jinesh C Jain
Optical emission spectroscopic studies have been carried out to investigate the pressure effect of CO<sub>2</sub> on laser-produced underwater plasma. The plasma was generated by focusing 1064 nm, 6 ns pulses from a Nd:YAG laser in a CO<sub>2</sub>-bearing solution. The temporal evolution of the continuum emission, Sr and Ba lines, and plasma electron density and temperature was characterized under CO<sub>2</sub> pressure ranging from 10 to 300 bars. The electron density measurements were made using the Stark broadening of the 455...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906208/70%C3%A2-%C3%A2-ghz-arbitrary-modulation-of-chirped-laser-pulses-by-means-of-acousto-optics
#18
Konstantin B Yushkov, Vitaliy V Romanov, Georgiy S Rogozhnikov, Vladimir Ya Molchanov
We report the arbitrary modulation of chirped ultrashort laser pulses with a 70 GHz bandwidth. In the proof-of-principle experiment, modulation of Ti:sapphire laser emission was performed by the acousto-optic dispersive delay line, and the temporal pulse shape was measured with a picosecond streak camera.
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906203/two-phase-slipi-for-instantaneous-lif-and-mie-imaging-of-transient-fuel-sprays
#19
Michael Storch, Yogeshwar Nath Mishra, Matthias Koegl, Elias Kristensson, Stefan Will, Lars Zigan, Edouard Berrocal
We report in this Letter a two-phase structured laser illumination planar imaging [two-pulse SLIPI (2p-SLIPI)] optical setup where the "lines structure" is spatially shifted by exploiting the birefringence property of a calcite crystal. By using this optical component and two cross-polarized laser pulses, the shift of the modulated pattern is not "time-limited" anymore. Consequently, two sub-images with spatially mismatched phases can be recorded within a few hundred of nanoseconds only, freezing the motion of the illuminated transient flow...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27906187/systemic-application-of-3-methyladenine-markedly-inhibited-atherosclerotic-lesion-in-apoe-mice-by-modulating-autophagy-foam-cell-formation-and-immune-negative-molecules
#20
Shen Dai, Bo Wang, Wen Li, Liyang Wang, Xingguo Song, Chun Guo, Yulan Li, Fengming Liu, Faliang Zhu, Qun Wang, Xiaoyan Wang, Yongyu Shi, Jianing Wang, Wei Zhao, Lining Zhang
A growing body of evidence demonstrates that autophagy, an evolutionarily conserved intracellular degradation process, is involved in the pathogenesis of atherosclerosis and has become a potential therapeutic target. Here we tested the effect of two inhibitors of phosphatidylinositol 3-kinase, 3-methyladenine (3-MA) and 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), commonly used as inhibitors of autophagy, in atherosclerosis in apolipoprotein E(-/-) mice. Systemic application of 3-MA but not LY294002 markedly reduced the size of atherosclerotic plaque and increased the stability of lesions in high-fat diet-fed mice as compared with controls...
December 1, 2016: Cell Death & Disease
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