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https://www.readbyqxmd.com/read/28096959/the-effect-of-aminoguanidine-on-sperm-motility-and-mitochondrial-membrane-potential-in-varicocelized-rats
#1
Rafieh Alizadeh, Shadan Navid, Niloofar Abbasi, Abazar Yari, Zohreh Mazaheri, Erfan Daneshi, Ashok Agarwal, Mehdi Abbasi
OBJECTIVES: Increased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicocelized rats. MATERIALS AND METHODS: Twenty fore male Wister rats were divided into control, sham, varicocele, and treatment groups...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28078226/clinical-utility-of-sperm-dna-fragmentation-testing-practice-recommendations-based-on-clinical-scenarios
#2
REVIEW
Ashok Agarwal, Ahmad Majzoub, Sandro C Esteves, Edmund Ko, Ranjith Ramasamy, Armand Zini
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078225/testicular-compartment-syndrome-an-overview-of-pathophysiology-etiology-evaluation-and-management
#3
REVIEW
Jason Gandhi, Gautam Dagur, Yefim R Sheynkin, Noel L Smith, Sardar Ali Khan
Testicular compartment syndrome (TCS) refers to the impairment of microcirculation in the testicle due to either increased venous resistance or extraluminal compression, which leads to hypoxia. TCS releases oxidants through hypoxia and ischemia/reperfusion injury (IRI). The pathophysiology, etiology, evaluation, and management of TCS are reviewed. Based on the properties of TCS, specific causes, e.g., varicocele, hydrocele, orchitis, cryptorchidism, and scrotal hernia, are suggested and categorized. The oxidant-induced stress from TCS may explain the correlations between these causes and infertility...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078218/effects-of-varicocelectomy-on-serum-testosterone
#4
REVIEW
Patrick Whelan, Laurence Levine
Varicocele is most often surgically repaired due to male infertility, however, has recently been linked to low serum testosterone. This paper serves to review the current literature regarding varicocele and its subsequent repair on serum testosterone. Twenty-eight human studies were identified with fifteen showing improved serum testosterone after repair. The majority of the studies that demonstrated improvement had preoperative testosterone levels that were low or below normal. Additionally, multiple well-designed studies with control groups not undergoing surgical repair demonstrated significant difference between groups...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28073193/analysis-of-myo-inositol-effect-on-spermatozoa-motility-in-hyper-viscous-ejaculates-and-in-patients-with-grades-ii-and-iii-varicocele
#5
Filomena Scarselli, Anna Maria Lobascio, Mario Terribile, Valentina Casciani, Pierfrancesco Greco, Giorgio Franco, Maria Giulia Minasi, Ermanno Greco
The goal of this study is to evaluate MYOInositol effects on spermatozoa motility, in patients' ejaculates with severe varicocele or hyper viscosity. The study included normal viscosity ejaculate from 30 patients affected by varicocele and hyper viscosity ejaculate from 33 patients without any testicular pathologies. All selected samples showed sperm concentration > 2 million/ml and progressive motility < 32%. In both groups, the pellet obtained after centrifugation in buffered medium, was divided in two aliquots, both incubated for 15 minutes at 37°C: one with MYO-Inositol and the other one, as control, only in phosphate buffered saline (PBS)...
December 30, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28063682/recurrence-rates-in-pediatric-patients-undergoing-microsurgical-subinguinal-varicocelectomy-with-and-without-testicular-delivery
#6
Chang Il Choi, Kyung Chae Park, Tae Ho Lee, Young Kwon Hong
BACKGROUND/PURPOSE: The purpose of the study was to determine if testicular delivery during microsurgical subinguinal varicocelectomy (MSV) reduces varicocele recurrence rates in pediatric patients. Testicular delivery during MSV enables ligation of the gubernacular veins, which is thought to reduce the likelihood of varicocele recurrence. However, recent studies have suggested that testicular delivery during MSV does not offer any beneficial effect and, therefore, may be optional or unnecessary...
December 24, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28062178/testicular-shear-wave-elastography-in-normal-and-infertile-men-a-prospective-study-on-601-patients
#7
Laurence Rocher, Aline Criton, Jean-Luc Gennisson, Vincent Izard, Sophie Ferlicot, Mickael Tanter, Gerard Benoit, Marie France Bellin, Jean-Michel Correas
Our aim in the study described here was to prospectively establish the feasibility of using and reproducibility of testicular shear-wave elastography in the assessment of testicular stiffness in 62 normal patients and 539 infertile men with obstructive azoospermia (OA), non-Klinefelter syndrome non-obstructive azoospermia (non-KS NOA), Klinefelter syndrome NOA (KS NOA), oligoasthenoteratozoospermia (OAT) or a left varicocele. The feasibility rate was 96.9%, with an intra-class correlation coefficient of 0.85 (95% confidence interval: 0...
January 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28042049/a-novel-approach-of-microscopic-subinguinal-varicocelectomy-with-a-pulling-strategy
#8
Wu Kerong, Yan Guang, Yin Weiqi, Chen Xueqin, Wang Guoyao, Cheng Yue
OBJECTIVES: To investigate the safety and efficacy of a novel approach of microscopic subinguinal varicocelectomy with a "pulling" strategy. METHODS: Fifty-two male patients with varicocele were enrolled in this study. Twenty-six patients underwent conventional microscopic subinguinal varicocelectomy, whereas the remaining 26 patients accepted our novel approach of treatment. In this method, with a subinguinal incision, we dissociated the spermatic cord from the external ring...
December 29, 2016: Urology
https://www.readbyqxmd.com/read/27992945/inhibition-of-poly-adp-ribose-polymerase-may-have-preventive-potential-for-varicocoele-associated-testicular-damage-in-rats
#9
C Celik-Ozenci, N Kuscu, N E Gungor-Ordueri, A Tasatargil, P Sahin, H Durmus
Varicocele is ordinarily accompanied by testicular damage and male infertility. Several theories have been proposed to explain the detrimental effect of varicocele on testis tissue, including the possible effects of oxidative stress. The poly(ADP-ribose) polymerase (PARP) pathway has been established as a major downstream intracellular pathway of oxidative stress. Recently we have reported that PARP pathway has been activated in varicocele-induced rat testicular damage model. The aim of the present study was to investigate the possible protective effect of PARP inhibition in varicocele-associated testicular damage...
December 19, 2016: Andrology
https://www.readbyqxmd.com/read/27979554/re-increased-body-mass-index-in-men-with-varicocele-is-associated-with-larger-spermatic-vein-diameters-when-supine
#10
Craig Niederberger
No abstract text is available yet for this article.
January 2017: Journal of Urology
https://www.readbyqxmd.com/read/27973977/risk-of-varicocele-in-patients-with-rheumatoid-arthritis-ankylosing-spondylitis-and-psoriatic-disease-a-population-based-case-control-study
#11
H-Y Chiu, I-T Wang, W-F Huang, Y-W Tsai, T-F Tsai
No abstract text is available yet for this article.
December 15, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27932281/nutcracker-syndrome-a-rare-cause-of-left-flank-pain-that-can-also-manifest-as-unexplained-pelvic-pain
#12
Jean-Marie Berthelot, Frédéric Douane, Yves Maugars, Eric Frampas
Nutcracker syndrome (NCS) is symptomatic unilateral renal venous hypertension due to compression of the left renal vein between the superior mesenteric artery and aorta (anterior NCS) or between the aorta and spine (posterior NCS). The left ovarian or spermatic vein empties into the left renal vein and is an additional site of venostasis in about half the cases of NCS. The presenting symptom of NCS in about half the cases is atypical left flank pain suggesting a disorder of the lower ribs or thoracolumbar spinal junction, particularly as the pain worsens with standing and increased lumbar lordosis...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27915088/exploring-awareness-and-help-seeking-intentions-for-testicular-symptoms-among-heterosexual-gay-and-bisexual-men-in-ireland-a-qualitative-descriptive-study
#13
Mohamad M Saab, Margaret Landers, Josephine Hegarty
BACKGROUND: The incidence of malignant and benign testicular disorders among young men is on the rise. Evidence from three reviews suggest that men's knowledge of these disorders is lacking and their help-seeking intention for testicular symptoms is suboptimal. Qualitative studies have addressed men's awareness of testicular cancer, with none exploring their awareness of non-malignant diseases such as epididymitis, testicular torsion, and varicocele and none including sexual minorities...
November 28, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27914143/urologic-diseases-in-korean-military-population-a-6-year-epidemiological-review-of-medical-records
#14
Se Young Choi, Chang Gyo Yoon
We sought to describe the incidence rate of the urologic disease in the Korean military by reviewing diagnoses made in active duty soldiers from 2008 to 2013. A total of 72,248 first visits were generated in the Defense Medical Statistics Information System (DMSIS) with its gradually increasing trend over 6 years. A sharp increase of first visit was observed after implementation of the regular health check-up for all conscripted soldiers since 2013. Urolithiasis, prostatitis, epididymoorchitis, urethritis, and varicocele were prevalent...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27878108/can-ultrasound-findings-be-a-good-predictor-of-sperm-parameters-in-patients-with-varicocele-a-cross-sectional-study
#15
Ali Mahdavi, Reza Heidari, Mehrdad Khezri, Abolfazl Shiravi, Reyhaneh Pirjani, Reyhaneh Saheb Kashaf
BACKGROUND: Varicocele, one of the most common causes of sperm abnormalities in men, is the dilation of the testicular vein (the pampiniform venous plexus) by more than 2 mm. Ultrasonography is the primary imaging procedure for varicocele diagnosis. The venous diameter is evaluated using B-mode sonography, and venous reflux is assessed using color Doppler sonography. OBJECTIVES: In this study, we investigated the association of ultrasound findings with sperm parameters in patients with varicocele...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27867844/surgical-approaches-for-varicocele-in-pediatric-patient
#16
Alejandra Parrilli, Agnese Roberti, Maria Escolino, Ciro Esposito
BACKGROUND: Varicocele represents one of the most common surgically correctible urologic anomalies in adolescent males. The best procedure for the treatment of adolescent varicocele has not been established, but with recent advances in minimal access surgery, there have been many reports praising the safety and efficacy of laparoscopy and retroperitoneoscopy for the surgical correction of varicocele in adolescent. The aim of this review is to compare the results of Palomo's technique, with retroperitoneoscopic and transperitoneoscopic approaches in adolescent, analyzing recurrence, testicular growth and complications...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27864361/causes-of-male-infertility-a-9-year-prospective-monocentre-study-on-1737-patients-with-reduced-total-sperm-counts
#17
M Punab, O Poolamets, P Paju, V Vihljajev, K Pomm, R Ladva, P Korrovits, M Laan
STUDY QUESTION: What are the primary causes of severe male factor infertility? SUMMARY ANSWER: Although 40% of all patients showed primary causes of infertility, which could be subdivided into three groups based on the severity of their effect, ~75% of oligozoospermia cases remained idiopathic. WHAT IS KNOWN ALREADY: There are few large-scale epidemiological studies analyzing the causes of male factor infertility. STUDY DESIGN, SIZE, DURATION: A prospective clinical-epidemiological study was conducted at the Andrology Centre, Tartu University Hospital between 2005 and 2013, recruiting male partners of couples failing to conceive a child for over ≥12 months...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27842996/the-varicocele-as-related-to-fertility
#18
EDITORIAL
Martin Kathrins
Brown JS, Dubin L, Hotchkiss RS. The varicocele as related to fertility. Fertil Steril 1967;18:46-56. "The fact that some men with varicoceles are fertile should not minimize the potentially detrimental role of this abnormality. It would be reasonable to claim that varicocele is uniformly detrimental. One might postulate that a fertile man with a varicocele would have better semen without this condition."
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27825660/the-validation-of-the-clinical-male-pelvic-trainer-mk-2-advanced-models-for-scrotal-examination-simulation
#19
Mithun Kailavasan, Ahmad Abdul-Rahman, Vishwanath Hanchanale, Sanjay Rajpal, Karol Rogawski, Victor Palit, Andy Myatt, Sunjay Jain, Chandra Shekhar Biyani
OBJECTIVES: To validate the use of a novel physical model, the "Clinical Male Pelvic Trainer (CMPT) Mk 2-Advanced," for scrotal examination simulation and evaluate its use for surgical education. MATERIALS AND METHODS: A total of 7 CMPT Mk 2-Advanced scrotal models were used for teaching: normal, varicocele, testicular tumor, epididymal cyst, hydrocele, epididymo-orchitis, and indirect inguinoscrotal hernia. At 4 surgical courses in the West Yorkshire Foundation Deanery, UK, between 2015 and 2016, trainees were asked to assess their clinical experience, confidence levels in diagnosing scrotal pathology and simulation properties of the scrotal models on a 5-point Likert Scale...
November 4, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27825582/-comparison-of-subinguinal-microsurgical-varicocelectomy-vs-percutaneous-embolization-in-infertile-men
#20
M Binhazzaa, E Bounasr, G Perez, T Almont, M Soulie, M Faruch, E Huyghe
INTRODUCTION: Subinguinal microscopic ligation is the current standard of treatment of varicocele, and percutaneous embolization is a new alternative. We aimed to compare these procedures for reproductive and functional aspects. MATERIAL: A consecutive series of 76 patients with clinical varicocele, alteration of semen parameters and infertility, undergoing either procedure (microsurgery in 49 cases and embolization in 27 cases) was prospectively analyzed preoperatively and postoperatively (at 1, 3, 6, 9 and 12 months)...
December 2016: Progrès en Urologie
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