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https://www.readbyqxmd.com/read/29138543/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-after-intravitreal-ranibizumab-for-age-related-macular-degeneration
#1
Dimitrios Karagiannis, Irini Chatziralli, Konstantinos Kaprinis, Ilias Georgalas, Efstratios Parikakis, Panagiotis Mitropoulos
Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months' follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29127511/adjacent-segment-degeneration-after-intervertebral-fusion-surgery-by-means-of-cervical-block-vertebrae
#2
Xinlong Ma, Yuren Du, Shuli Wang, Jianxiong Ma, Tao Wang, Mingjie Kuang, Baoyi Ma
BACKGROUND: The prevalence of cervical block vertebrae is unknown. Furthermore, there is no consensus on the cause of adjacent segment degeneration (ASD) after cervical fusion. QUESTIONS/PURPOSES: (1) What is the incidence of cervical block vertebrae? Is there a gender difference? (2) Among cervical block vertebrae cases, is ASD related to age and segment? And what is the specific relationship? (3) What are the imaging findings and characteristics of this disease? PATIENTS AND METHODS: We retrospectively diagnosed cervical block vertebrae cases with bony fusions in any segments of the cervical spine without intervertebral fusion surgery of 33,762 patients reported from 2006 to 2011 in north China...
November 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29125227/pichia-pastoris-alcohol-oxidase-1-aox1-core-promoter-engineering-by-high-resolution-systematic-mutagenesis
#3
Rui M C Portela, Thomas Vogl, Katharina Ebner, Rui Oliveira, Anton Glieder
Unravelling the core promoter sequence-function relationship is fundamental for engineering transcription initiation and thereby a feasible 'tuning knob' for fine-tuning expression in synthetic biology and metabolic engineering applications. Here a systematic replacement studies of the core promoter and 5' untranslated region (5'UTR) of the exceptionally strong and tightly methanol regulated Komagataella phaffii (syn. Pichia pastoris) alcohol oxidase 1 (AOX1) promoter at unprecedented resolution was performed...
November 10, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29107435/growing-cyst-like-white-matter-lesions-in-children-with-neurofibromatosis-type-1
#4
Ji Eun Kim, Jung-Eun Cheon, In-One Kim, Young-Hun Choi, Woo Sun Kim
BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal dominant disease with prominent neurocutaneous manifestations. The most common intracranial imaging finding of NF1 on brain magnetic resonance imaging (MRI) is the high-signal intensity foci without a mass effect or growth in size. PATIENT DESCRIPTION: We describe two children with NF1 in whom brain MRI showed growing cystic lesions and adjacent white matter signal abnormalities, which were confirmed as non-neoplastic cystic degeneration and reactive gliosis...
August 4, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29101465/changes-in-cervical-motion-after-cervical-spinal-motion-preservation-surgery
#5
Chi Heon Kim, Tae Hyun Park, Chun Kee Chung, Kyoung-Tae Kim, Yun Hee Choi, Seok-Won Chung
BACKGROUND: For patients with single-level cervical radiculopathy, various types of motion preservation surgeries, such as total disc replacement (TDR), posterior cervical foraminotomy (PCF) and posterior percutaneous endoscopic foraminotomy and discectomy (PECF), are available. In addition to motion preservation, the quality of motion is an important issue. The aim of the present study was to evaluate the influence of these surgeries on cervical motion by comparing the instantaneous axis of rotation (IAR) among PECF, TDR and PCF at the index and superior/inferior adjacent segments...
November 3, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29101314/clinical-and-radiological-analysis-of-bryan-cervical-artificial-disc-replacement-for-skip-multi-segment-cervical-spondylosis-long-term-follow-up-results
#6
Zikun Shang, Yingze Zhang, Di Zhang, Wenyuan Ding, Yong Shen
BACKGROUND The aim of this study was to retrospectively analyze the clinical and radiological efficacy of Bryan cervical artificial disc replacement (ADR) for "skip" multi-segment cervical spondylosis (SCS). MATERIAL AND METHODS We enrolled 49 patients with SCS treated with either Bryan cervical ADR (18 cases) or ACDF (31 cases). Each case was evaluated preoperatively and at more than 48 months postoperatively in follow-up using the JOA, NDI, and VAS. Cervical sagittal curvature, total cervical ROM, and degree of middle segments of motion were also evaluated...
November 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29094203/creation-of-miniature-pig-model-of-human-waardenburg-syndrome-type-2a-by-enu-mutagenesis
#7
Tang Hai, Weiwei Guo, Jing Yao, Chunwei Cao, Ailing Luo, Meng Qi, Xianlong Wang, Xiao Wang, Jiaojiao Huang, Ying Zhang, Hongyong Zhang, Dayu Wang, Haitao Shang, Qianlong Hong, Rui Zhang, Qitao Jia, Qiantao Zheng, Guosong Qin, Yongshun Li, Tao Zhang, Weiwu Jin, Zheng-Yi Chen, Hongmei Wang, Qi Zhou, Anming Meng, Hong Wei, Shiming Yang, Jianguo Zhao
Human Waardenburg syndrome 2A (WS2A) is a dominant hearing loss (HL) syndrome caused by mutations in the microphthalmia-associated transcription factor (MITF) gene. In mouse models with MITF mutations, WS2A is transmitted in a recessive pattern, which limits the study of hearing loss (HL) pathology. In the current study, we performed ENU (ethylnitrosourea) mutagenesis that resulted in substituting a conserved lysine with a serine (p. L247S) in the DNA-binding domain of the MITF gene to generate a novel miniature pig model of WS2A...
November 1, 2017: Human Genetics
https://www.readbyqxmd.com/read/29082670/two-visual-systems-in-one-eyestalk-the-unusual-optic-lobe-metamorphosis-in-the-stomatopod-alima-pacifica
#8
Chan Lin, Thomas W Cronin
The compound eyes of adult stomatopod crustaceans have two to six ommatidial rows at the equator, called the midband, that are often specialized for color and polarization vision. Beneath the retina, this midband specialization is represented as enlarged optic lobe lamina cartridges and a hernia-like expansion in the medulla. We studied how the optic lobe transforms from the larvae, which possess typical crustacean larval compound eyes without a specialized midband, through metamorphosis into the adults with the midband in a two midband-row species Alima pacifica...
October 30, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29077458/giant-quantum-hall-plateau-in-graphene-coupled-to-an-inse-van-der-waals-crystal
#9
Z R Kudrynskyi, M A Bhuiyan, O Makarovsky, J D G Greener, E E Vdovin, Z D Kovalyuk, Y Cao, A Mishchenko, K S Novoselov, P H Beton, L Eaves, A Patanè
We report on a "giant" quantum Hall effect plateau in a graphene-based field-effect transistor where graphene is capped by a layer of the van der Waals crystal InSe. The giant quantum Hall effect plateau arises from the close alignment of the conduction band edge of InSe with the Dirac point of graphene. This feature enables the magnetic-field- and electric-field-effect-induced transfer of charge carriers between InSe and the degenerate Landau level states of the adjacent graphene layer, which is coupled by a van der Waals heterointerface to the InSe...
October 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29076467/-analysis-of-the-results-of-total-cervical-disc-arthroplasty-using-a-m6-c-prosthesis-a-multicenter-study
#10
V A Byval'tsev, A A Kalinin, I A Stepanov, Yu Ya Pestryakov, V V Shepelev
Cervical spondylosis and intervertebral disc (IVD) degeneration are the most common cause for compression of the spinal cord and/or its roots. Total IVD arthroplasty, as a modern alternative to surgical treatment of IVD degeneration, is gaining popularity in many neurosurgical clinics around the world. Aim - the study aim was to conduct a multicenter analysis of cervical spine arthroplasty with an IVD prosthesis M6-C ('Spinal Kinetics', USA). MATERIAL AND METHODS: The study included 112 patients (77 males and 35 females)...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29066708/survivorship-analysis-of-clinical-adjacent-segment-pathology-after-single-level-cervical-fusion
#11
Lingde Kong, Qinghua Ma, Kunlun Yu, Junming Cao, Linfeng Wang, Yong Shen
BACKGROUND Clinical adjacent-segment pathology (CASP) is an important problem after anterior cervical surgery. The purpose of this study was to predict prevalence of CASP and determine the possible risk factors for CASP after single-level anterior cervical discectomy and fusion surgery. MATERIAL AND METHODS We retrospectively reviewed a series of patients who underwent single-level cervical discectomy and fusion surgery (ACDF). Both basic and radiographic data of patients were collected. Life-table method and Kaplan-Meier analysis were used to calculate prevalence of CASP and disease-free survival rate...
October 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29063365/intervertebral-disc-degeneration-an-experimental-and-numerical-study-using-a-rabbit-model
#12
Andrea Calvo-Echenique, José Cegoñino, Laura Correa-Martín, Luciano Bances, Amaya Pérez-Del Palomar
Animal models have been extensively used for the study of degenerative diseases and evaluation of new therapies to stop or even reverse the disease progression. The aim of this study is to reproduce lumbar intervertebral disc degeneration in a rabbit model by performing a percutaneous annular puncture at L4L5 level. The effect of this damage on the spine behaviour was analysed combining three different techniques: imaging processing, mechanical testing and computational modelling. Twenty New Zealand white rabbits were divided into control and experimental groups and followed up during 6 months...
October 23, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29063273/clinical-and-radiological-results-of-posterior-cervical-foraminotomy-at-two-or-three-levels-a-3-year-follow-up
#13
Dong Geun Lee, Choon Keun Park, Dong Chan Lee
BACKGROUND: Single-level unilateral posterior cervical foraminotomy is regarded as a safe method. However, the outcomes of posterior cervical foraminotomy performed on two or three levels are uncertain and debated. We aimed to analyze the long-term clinical and radiological outcomes of posterior cervical foraminotomy at two or three levels. METHODS: From September 2008 to December 2011, a total of 42 patients who underwent a posterior cervical foraminotomy at two or three levels and were followed for at least 3 years were analyzed with retrospective cohort study...
October 23, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29057641/anti-vascular-endothelial-growth-factor-therapy-for-myopic-choroidal-neovascularization
#14
Danny S C Ng, Timothy Y Y Lai, Chui Ming Gemmy Cheung, Kyoko Ohno-Matsui
Myopic choroidal neovascularization (CNV) is one of the most vision-impairing complications in patients with pathologic myopia. It is also one of the most frequently encountered non‒age-related macular degeneration causes of CNV and affects young patients in the working age group. Fluorescein angiography (FA) and spectral domain optical coherence tomography (OCT) are generally indicated to confirm the diagnosis of active myopic CNV before initiation of treatment. Without treatment, natural history studies have shown that the vision outcome can be very poor...
October 20, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29057356/anterior-cervical-spine-surgery-associated-complications-in-a-retrospective-case-control-study
#15
REVIEW
Anastasia Tasiou, Theofanis Giannis, Alexandros G Brotis, Ioannis Siasios, Iordanis Georgiadis, Haralampos Gatos, Eleni Tsianaka, Konstantinos Vagkopoulos, Konstantinos Paterakis, Kostas N Fountas
Anterior cervical spine procedures have been associated with satisfactory outcomes. However, the occurrence of troublesome complications, although uncommon, needs to be taken into consideration. The purpose of our study was to assess the actual incidence of anterior cervical spine procedure-associated complications and identify any predisposing factors. A total of 114 patients undergoing anterior cervical procedures over a 6-year period were included in our retrospective, case-control study. The diagnosis was cervical radiculopathy, and/or myelopathy due to degenerative disc disease, cervical spondylosis, or traumatic cervical spine injury...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29050192/-advances-in-research-of-exosomes-and-age-related-macular-degeneration
#16
M Q Xu, X D Sun
Exosomes are small vesicles with a molecular diameter of 30 to 100 nm, which are secreted into the cell after the fusion of the multivesicular bodies with the plasma membrane. Exosomes contain various molecular constituents of their cell origin, including proteins, microRNAs and lipids. Different cell-derived exosomes have different biological functions. Exosomes play a very important role in the development and progression of age-related macular degeneration (AMD). The exosomes derived from the eye are involved in the processes of cell growth, metastasis, angiogenesis and immunosuppression by transferring contents to adjacent or distant cells...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29035751/intercellular-transfer-of-pathogenic-%C3%AE-synuclein-by-extracellular-vesicles-is-induced-by-the-lipid-peroxidation-product-4-hydroxynonenal
#17
Shi Zhang, Erez Eitan, Tsung-Yu Wu, Mark P Mattson
Parkinson's disease (PD) is characterized by accumulations of toxic α-synuclein aggregates in vulnerable neuronal populations in the brainstem, midbrain, and cerebral cortex. Recent findings suggest that α-synuclein pathology can be propagated transneuronally, but the underlying molecular mechanisms are unknown. Advances in the genetics of rare early-onset familial PD indicate that increased production and/or reduced autophagic clearance of α-synuclein can cause PD. The cause of the most common late-onset PD is unclear, but may involve metabolic compromise and oxidative stress upstream of α-synuclein accumulation...
September 22, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29033290/nonvascularized-cartilage-grafts-versus-vascularized-cartilage-flaps-comparison-of-cartilage-quality-6%C3%A2-months-after-transfer-and-isolated-from-surrounding%C3%A2-bone-ingrowth
#18
James P Higgins, Farzad Borumandi, Heinz K Bürger, Mehmet Emre Benlidayı, Anna Vasilyeva, Leman Sencar, Sait Polat, Alexander J Gaggl
PURPOSE: Subchondral perfusion of osteochondral grafts has been shown to be important in preventing long-term cartilage degeneration. In carpal reconstruction, subchondral perfusion from the graft bed is limited. This study's purpose was to compare the histological characteristics of cartilage in osteochondral grafts supported by synovial imbibition alone to cartilage of vascularized osteochondral flaps that have both synovial and vascular pedicle perfusion. METHODS: Two adjacent osteochondral segments were harvested on the medial femoral trochlea in domestic 6- to 8-month-old pigs...
October 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29032381/analysis-of-correlation-between-vertebral-endplate-change-and-lumbar-disc-degeneration
#19
Long Xiao, Chunlin Ni, Jiandong Shi, Zhirong Wang, Suchun Wang, Jianwei Zhang, Aiqing Lu
BACKGROUND To evaluate the correlation between vertebral endplate change and the level of lumbar disc degeneration via magnetic resonance imaging (MRI). MATERIAL AND METHODS A total of 345 patients who were recruited from our hospital from May 2012 to May 2016 were evaluated for the presence of intervertebral disc degeneration or herniation. The degree of degeneration was assessed according to Pfirrmann grade. Vertebral endplate change was evaluated based on the endplate concave angle (ECA), and Modic change on sagittal MRI...
October 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29019878/a-comparison-of-anterior-cervical-discectomy-and-fusion-combined-with-cervical-disc-arthroplasty-and-cervical-disc-arthroplasty-for-the-treatment-of-skip-level-cervical-degenerative-disc-disease-a-retrospective-study
#20
COMPARATIVE STUDY
Ting-Kui Wu, Bei-Yu Wang, Ming-Dan Deng, Ying Hong, Xin Rong, Hua Chen, Yang Meng, Hao Liu
Anterior cervical discectomy and fusion (ACDF) has been widely performed for the treatment of multilevel cervical degenerative disc disease (CDDD). In recent decades, cervical disc arthroplasty (CDA) and hybrid surgery (HS) have been developed to overcome the shortcomings of ACDF. Controversy still remains with regard to the optimal surgical procedure for skip-level CDDD.A total of 55 patients who received surgical treatment for skip-level CDDD in our department were reviewed. The patients were divided into the HS group (n = 29) and the CDA group (n = 26)...
October 2017: Medicine (Baltimore)
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