keyword
MENU ▼
Read by QxMD icon Read
search

adjacent degeneration

keyword
https://www.readbyqxmd.com/read/29325074/cervical-disc-arthroplasty-current-evidence-and-real-world-application
#1
Pierce D Nunley, Domagoj Coric, Kelly A Frank, Marcus B Stone
Cervical total disc replacement (cTDR) is still considered a developing technology, with widespread clinical use beginning in the early 2000s. Despite being relatively new to the marketplace, the literature surrounding cTDR is abundant. We conducted a thorough review of literature published in the United States (US) and outside the US to report the current global state of cTDR research and clinical use. Search criteria were restricted to publications with a clinical patient population, excluding finite element analyses, biomechanical studies, cadaver studies, surgical technique-specific papers, and case studies...
January 6, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29322911/comparison-of-lumbar-pedicular-dynamic-stabilisation-systems-versus-fusion-for-the-treatment-of-lumbar-degenerative-disc-disease-a-meta-analysis
#2
Y-J Huang, S-J Zhao, Q Zhang, L-M Nong, N-W Xu
This study aimed to systematically compare the safety, effectiveness and radiological changes after lumbar pedicular dynamic stabilisation systems and fusion to treat lumbar degenerative disc disease . All studies that were performed to compare various lumbar pedicular dynamic stabilisation systems with any lumbar fusion to treat lumbar degenerative disc disease and were published until April 30, 2015 were acquired through a comprehensive search in various databases. A meta-analysis was performed after the methodological qualities of trials were assessed and after data were extracted...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29315121/cervical-total-disk-arthroplasty
#3
Timothy T Roberts, Ryan J Filler, Jason W Savage, Edward C Benzel
In the United States, cervical total disk arthroplasty (TDA) is US Federal Drug Administration (FDA) approved for use in both 1 and 2-level constructions for cervical disk disease resulting in myelopathy and/or radiculopathy. TDA designs vary in form, function, material composition, and even performance in vivo. However, the therapeutic goals are the same: to remove the painful degenerative/damaged elements of the intervertebral discoligamenous joint complex, to preserve or restore the natural range of spinal motion, and to mitigate stresses on adjacent spinal segments, thereby theoretically limiting adjacent segment disease (ASDis)...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29315118/characteristics-of-cervical-spine-motion-in-different-types-of-cervical-alignment-kinematic-mri-study
#4
Kittipong Sessumpun, Permsak Paholpak, Kevork N Hindoyan, Koji Tamai, Thananit Sangkomkamhang, Zorica Buser, Jeffrey C Wang
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate how each type of sagittal cervical alignment affects the motion of the upper and subaxial cervical spine using kinematic magnetic resonance imaging. SUMMARY OF BACKGROUND DATA: The sagittal malalignment of the cervical spine from degeneration in the subaxial cervical spine reflects a disruption in the kinematic properties of the cervical spine and affects the motion of adjacent segments...
January 8, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29307048/biomechanical-analysis-of-a-new-lumbar-interspinous-device-with-optimized-topology
#5
Chen-Sheng Chen, Shih-Liang Shih
Interspinous spacers used stand-alone preserve joint movement but provide little protection for diseased segments of the spine. Used as adjuncts with fusion, interspinous spacers offer rigid stability but may accelerate degeneration on adjacent levels. Our new device is intended to balance the stability and preserves motion provided by the implant. A new interspinous spacer was devised according to the results of topology optimization studies. Four finite element (FE) spine models were created that consisted of an intact spine without an implant, implantation of the novel, the device for intervertebral assisted motion (DIAM system), and the Dynesys system...
January 6, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29288377/outcomes-of-the-bryan-cervical-disc-replacement-fifteen-year-follow-up
#6
Vincent Pointillart, Jean-Etienne Castelain, Pierre Coudert, Derek Thomas Cawley, Olivier Gille, Jean-Marc Vital
BACKGROUND: The CTDR is a technique that treats cervical disc degenerative disease. Initial shorter-term studies showed good clinical and radiological results. PURPOSE: To assess the clinical and radiological results of Bryan cervical disc replacement (Medtronic Sofamor Danek Inc., Memphis, TN) at 15-year follow-up. RESULTS: This prospective study included 20 patients who underwent 22 CTDR, comprising a single-level procedure in 14 patients and two-level procedures in six patients...
December 29, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29286281/molecular-structure-of-human-katp-in-complex-with-atp-and-adp
#7
Kenneth Pak Kin Lee, Jue Chen, Roderick MacKinnon
In many excitable cells KATP channels respond to intracellular adenosine nucleotides: ATP inhibits while ADP activates. We present two structures of the human pancreatic KATP channel, containing the ABC transporter SUR1 and the inward-rectifier K+ channel Kir6.2, in the presence of Mg2+ and nucleotides. These structures, referred to as quatrefoil and propeller forms, were determined by single-particle cryo-EM at 3.9 Å and 5.6 Å, respectively. In both forms ATP occupies the inhibitory site in Kir6.2. The nucleotide-binding domains of SUR1 are dimerized with Mg2+-ATP in the degenerate site and Mg2+-ADP in the consensus site...
December 29, 2017: ELife
https://www.readbyqxmd.com/read/29284397/stem-progenitor-cells-and-biodegradable-scaffolds-in-the-treatment-of-retinal-degenerative-diseases
#8
Yuyao Wang, Dandan Zhang, Bingqiao Shen, Yi Zhang, Ping Gu
Visual impairment caused by retinal degeneration is primarily attributed to the irreversible degradation of retinal neurons or the adjacent retinal pigment epithelium (RPE). No efficient clinical therapies to restore or improve visual ability are currently available. Cell therapy has been touted as a promising strategy to overcome this challenge. Progenitor/stem cells may be obtained from both ocular and non-ocular tissues. The former mainly includes retinal progenitor cells (RPCs), whereas the latter comprises embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), which have been utilized in stem cell replacement therapy studies ranging from proof-of-concept animal models to clinical trials in humans...
December 27, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29247396/the-mechanism-in-junctional-failure-of-thoraco-lumbar-fusions-part-ii-analysis-of-a-series-of-pjk-after-thoraco-lumbar-fusion-to-determine-parameters-allowing-to-predict-the-risk-of-junctional-breakdown
#9
Antonio A Faundez, Jonathon Richards, Philippe Maxy, Rachel Price, Amélie Léglise, Jean-Charles Le Huec
PURPOSE: To identify risk factors, in 12 patients with junctional breakdown (JBD) after thoraco-sacral fusions and to test a software locating maximal bending moment on full spine EOS images. METHODS: Twelve patients underwent long fusions for lumbar degenerative pathologies. Preop EOS images were compared to first postop EOS showing JBD. Parameters analyzed were: spinopelvic parameters [pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), sagittal vertical axis (SVA), spinosacral angle (SSA), lordosis, and kyphosis], proximal junctional angle (PJA), odontoid-hip axis angle (ODHA), and CIA...
December 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29241405/cell-clusters-are-indicative-of-stem-cell-activity-in-the-degenerate-intervertebral-disc-can-their-properties-be-manipulated-to-improve-intrinsic-repair-of-the-disc
#10
Sharon Brown, Ajay Matta, William Mark Erwin, Sally Roberts, Helen H Gruber, Edward N Hanley, Christopher B Little, James Melrose
The aim of this study was to examine the complexity of the stem cell populations in the intervertebral disc (IVD) and understand their role in disc degeneration with a view to determining whether the resident stem cells could be developed for therapeutic purposes to combat IVD degeneration. Stem cells have been isolated from disc and paradiscal tissues including the notochord, annulus fibrosus (AF), nucleus pulposus (NP), cartilaginous endplate (CEP), ligamentum flavum and vertebral body. Resident AF and NP cells are relatively sparsely distributed occuring as single or occasional doublet cells surrounded by an extensive extracellular matrix (ECM)...
December 14, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29225397/concurrent-oct-imaging-of-stimulus-evoked-retinal-neural-activation-and-hemodynamic-responses
#11
Taeyoon Son, Benquan Wang, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes...
2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29220729/comparison-of-dynamic-cervical-implant-versus-anterior-cervical-discectomy-and-fusion-for-the-treatment-of-single-level-cervical-degenerative-disc-disease-a-five-year-follow-up
#12
Ce Zhu, Xi Yang, Lei Wang, Bo-Wen Hu, Li-Min Liu, Lin-Nan Wang, Hao Liu, Yue-Ming Song
OBJECTIVE: To compare clinical and radiographic outcomes of dynamic cervical implant(DCI) with anterior cervical discectomy and fusion(ACDF) in the treatment of single-level cervical degenerative disc disease (CDDD) 5 years after surgery. PATIENTS AND METHODS: Forty-three patients with DCI were matched one-to-one with patients with ACDF based on age, gender, and operative segment in this retrospective study. All patients had been followed up for more than 5 years...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29216503/clinical-and-radiographic-comparison-of-cervical-disc-arthroplasty-with-prestige-lp-disc-and-anterior-cervical-fusion-a-minimum-6-year-follow-up-study
#13
Junfeng Zeng, Hao Liu, Beiyu Wang, Yuxiao Deng, Chen Ding, Hua Chen, Yi Yang, Ying Hong, Ning Ning
OBJECTIVES: To retrospectively compare the long-term clinical and radiographic outcomes of cervical disc arthroplasty (CDA) with Prestige-LP Disc and anterior cervical discectomy and fusion (ACDF) for single-level cervical degenerative disc disease. PATIENTS AND METHODS: Ninety-eight patients (45 CDA and 53 ACDF) with a minimum 6-year follow-up were included. Clinical evaluations included Japanese Orthopedic Association (JOA), visual analogue scale (VAS), and Neck Disability Index (NDI) scores...
December 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29212437/k-rod-dynamic-internal-fixation-versus-microendoscopic-discectomy-for-the-treatment-of-single-segment-lumbar-disc-herniation
#14
Yang Qu, Meng Cheng, Rongpeng Dong, Mingyang Kang, Haohan Zhou, Jianwu Zhao
PURPOSE: This study compared the clinical outcome of K-rod dynamic internal fixation versus microendoscopic discectomy (MED) for the treatment of single-segment lumbar disc herniation. METHODS: This retrospective study included 34 patients with L4-L5 single-segment lumbar disc herniation who underwent K-rod dynamic internal fixation ( n = 18) or MED ( n = 16). The pain was evaluated by the Oswestry disability index (ODI) and visual analogue scale (VAS). The neurological function was assessed by the Japanese Orthopaedic Association (JOA) scores...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29200480/stitchless-percutaneous-endoscopic-cervical-discectomy-are-we-moving-towards-day-care-discectomy-procedure
#15
Sunil M Nadkarni, Pavankumar Kohli, Bhupesh Patel, Satishchandra Gore, Bhagyashree S Kulkarni
Background: STITCHLESS percutaneous endoscopic cervical discectomy s[PECD] is safe, precise, targeted, and a complete endoscopic procedure to treat soft cervical disc herniation with unilateral radiculopathy. It allows direct visualization of herniated fragment and its removal, inspection of decompressed nerve root in an awake and aware patient. It reduces the risk related to general anesthesia and to the neurological structures. However, all the patients treated with PECD can be candidates for anterior cervical discectomy and fusion (ACDF)...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29189218/adjacent-level-degeneration-bryan-total-disc-arthroplasty-versus-anterior-cervical-discectomy-and-fusion
#16
Justin Miller, Rick Sasso, Paul Anderson, K Daniel Riew, Austin McPhilamy, Thomas Gianaris
STUDY DESIGN: Prospective randomized, 2-center, clinical trial. OBJECTIVE: To prospectively compare adjacent level degeneration between the Bryan Cervical Disc Prosthesis and anterior cervical discectomy and fusion (ACDF), and assess the reliability of our measurements utilizing a method not previously described. SUMMARY OF BACKGROUND DATA: ACDF is a reliable and proven procedure for the treatment of radiculopathy and/or myelopathy. Despite a successful track record several limitations including adjacent segment degeneration/disease, loss of viscoelastic disc properties, perioperative immobilization, graft site morbidity, pseudarthrosis, and plating complications have been identified...
November 16, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29183306/acdf-vs-tdr-for-patients-with-cervical-spondylosis-an-8%C3%A2-year-follow-up-study
#17
Bolong Zheng, Dingjun Hao, Hua Guo, Baorong He
BACKGROUND: ACDF has been considered as the gold standard in the treatment of single level cervical disk protrusion. However, it may cause adjacent level degeneration due to regional biomechanical changes. TDR has been applied with satisfactory results for over a decade, but there is no consensus if TDR is safer and more efficient than ACDF. The current study was carried out to compare the efficiency and safety of TDR and ACDF in the treatment of patients with single level cervical disk protrusion...
November 28, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29181521/osteopathic-manipulative-treatment-for-the-management-of-adjacent-segment-pathology
#18
Drew D Lewis, Garth K Summers
Adjacent segment pathology is an adverse effect of spinal fusion that precipitates accelerated spinal degenerative changes at vertebral segments contiguous with the fused vertebrae. The accelerated degeneration related to ASP can be challenging to manage, as it can lead to conditions such as radiculopathy and can create the need for reoperation. In the present case, a 50-year-old woman with a previous spinal fusion presented with a 1-year history of progressive low back pain, lumbar radiculopathy, and sciatica...
December 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29180636/anterior-cervical-discectomy-and-fusion-surgery-versus-total-disc-replacement-a-comparative-study-with-minimum-of-10-year-follow-up
#19
Si-Dong Yang, Yan-Bo Zhu, Suo-Zhou Yan, Jun Di, Da-Long Yang, Wen-Yuan Ding
Based on long-term follow-ups, this study was designed to investigate the incidence and risk factors for postoperative adjacent segment degeneration (ASD) after anterior cervical discectomy and fusion (ACDF) or total disc replacement (TDR) in treating cervical degenerative diseases. Between January 2000 and December 2005, 108 cases undergoing ACDF and 78 undergoing TDR, were enrolled into this study. All medical records were retrospectively collected. Every patient was followed up at least 10 years. Outcome assessment included visual analogue scale (VAS) score, Neck Disability Index (NDI) score, Japanese Orthopaedic Association (JOA) score, and radiographic parameters...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176486/challenges-and-solutions-for-lumbar-total-disc-replacement-implantation
#20
Michael Janssen, Rolando Garcia, Lynn Miller, William Reed, Jack Zigler, Nicole Ferko, Sarah Hollmann
: Long-term data are now available to support the safety and efficacy of lumbar total disc replacement (TDR). Five-year randomized and controlled trials, meta-analyses, and observational studies support a similar or lower risk of complications with lumbar TDR compared with fusion. The panel concluded that published data on commercially available lumbar TDR devices demonstrate minimal concerns with late-onset complications, and that the risk of adjacent segment degeneration and reoperations can be reduced with lumbar TDR versus fusion...
December 15, 2017: Spine
keyword
keyword
56268
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"