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https://www.readbyqxmd.com/read/28443167/elderly-patients-achieving-clinical-and-radiological-outcomes-comparable-with-those-of-younger-patients-following-minimally-invasive-transforaminal-lumbar-interbody-fusion
#1
Joshi Nikhil N, Joel Wei-An Lim, William Yeo, Wai-Mun Yue
STUDY DESIGN: Retrospective analysis of prospective database. PURPOSE: To compare 2-year clinical and radiological outcomes after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) among "middle-age" (50-64.99 years), "young-old" (65-74.99 years), and "old-old" (>75 years) patients. OVERVIEW OF LITERATURE: Owing to higher perioperative morbidity and mortality rates, elderly patients with degenerative lumbar conditions are occasionally denied surgical care, even after conservative treatment failure...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28443164/single-level-minimally-invasive-transforaminal-lumbar-interbody-fusion-provides-sustained-improvements-in-clinical-and-radiological-outcomes-up-to-5-years-postoperatively-in-patients-with-neurogenic-symptoms-secondary-to-spondylolisthesis
#2
Hamid Rahmatullah Bin Abd Razak, Priyesh Dhoke, Kae-Sian Tay, William Yeo, Wai-Mun Yue
STUDY DESIGN: Retrospective review of prospective registry data. PURPOSE: To determine 5-year clinical and radiological outcomes of single-level instrumented minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in patients with neurogenic symptoms secondary to spondylolisthesis. OVERVIEW OF LITERATURE: MIS-TLIF and open approaches have been shown to yield comparable outcomes. This is the first study to assess MIS-TLIF outcomes using the minimal clinically important difference (MCID) criterion...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28436087/a-deeper-look-at-torpedo-maculopathy
#3
REVIEW
Casey Hamm, Diana Shechtman, Sherrol Reynolds
BACKGROUND: Torpedo maculopathy is a rare, congenital maculopathy classically diagnosed funduscopically as a 'torpedo-shaped' lesion located temporal to the fovea. This case describes a torpedo maculopathy with non-classic optical coherence tomographic (OCT) findings and collaborative OCT angiographic (OCTA) findings. CASE REPORT: A 60-year-old Caucasian woman presented with a history of longstanding distortion and paracentral scotoma of the right eye. She had a positive family history of age-related macular degeneration...
April 23, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28427981/ultrastructure-of-pericystic-or-intracystic-blood-vessels-in-epidermoid-cysts-a-transmission-electron-microscopy-study-laboratory-investigation
#4
Xiao-Hui Ren, Jun Ma, Chun Zeng, Yi-Lin Sun, Song Lin
OBJECTIVES: Recently, we reported the tendency towards the spontaneous hemorrhage in both pre- and post-operative periods of patients with intracranial epidermoid cyst (EC). According to our experience this tendency of spontaneous hemorrhage was partly due to the pathologic blood vessels adjacent to the EC. This article was designed to testify this hypothesis. MATERIALS & METHODS: 23 removable pericystic or intracystic blood vessels from 17 EC patients were collected during surgery, and then were examined by transmission electron microscope...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28427489/effects-of-structural-changes-in-subchondral-bone-on-articular-cartilage-in-a-beagle-dog-model
#5
Dong Yan, Tong Xi Liu, Bao Yue Liu, Ling Wang, Zhan Hua Qian, Xiao Guang Cheng, Kun Cheng Li
OBJECTIVE: Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. METHODS: Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group (n = 12) and a bone cement group (n = 12). Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side...
March 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28425757/the-prevalence-and-characteristics-of-a-subcortical-cystic-lesion-at-the-subspinous-region-of-the-knee
#6
Ji Ye Son, Young Cheol Yoon, Wook Jin, Jang Gyu Cha
Background Although we observed that subcortical cysts near the attachment of the meniscus or cruciate ligaments are frequently seen with a tear or degeneration of the adjacent meniscus and/or cruciate ligament, there is no large study describing the prevalence, distribution, and associated findings of these cysts. Purpose To evaluate the prevalence and distribution of subcortical cysts near the attachments of the meniscus or cruciate ligaments and evaluate pathologies of the meniscus or cruciate ligaments using magnetic resonance imaging (MRI)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28422837/multilevel-cervical-disc-replacement-versus-multilevel-anterior-discectomy-and-fusion-a-meta-analysis
#7
Ting-Kui Wu, Bei-Yu Wang, Yang Meng, Chen Ding, Yi Yang, Ji-Gang Lou, Hao Liu
BACKGROUND: Cervical disc replacement (CDR) has been developed as an alternative surgical procedure to anterior cervical discectomy and fusion (ACDF) for the treatment of single-level cervical degenerative disc disease. However, patients with multilevel cervical degenerative disc disease (MCDDD) are common in our clinic. Multilevel CDR is less established compared with multilevel ACDF. This study aims to compare the outcomes and evaluate safety and efficacy of CDR versus ACDF for the treatment of MCDDD...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421969/dystrophic-mineralization-of-costal-cartilage-in-hartley-guinea-pigs
#8
Alexandria M Schauer, Adrienne Schucker, Cathy S Carlson
Hartley guinea pigs are widely used animal models of disease, particularly in studies of osteoarthritis. The purpose of this study was to investigate lesions in the costal cartilage from 16 male, 5- to 6-month-old Hartley guinea pigs. Routine histological sections from the costal cartilage and costochondral junction (longitudinal and cross sections) and sternum (for evaluation of bone marrow) were examined. All 16 (100%) animals had histological lesions involving the costal cartilage that included matrix degeneration and mineralization, reduced cellularity, and evidence of chondrocyte necrosis...
April 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28416438/nsaid-use-in-intervertebral-disc-degeneration-what-are-the-effects-on-matrix-homeostasis-in-vivo
#9
Nicholas Vaudreuil, Tiffany Kadow, Takashi Yurube, Robert Hartman, Kevin Ngo, Qing Dong, Pedro Pohl, J Paulo Coelho, James Kang, Nam Vo, Gwendolyn Sowa
BACKGROUND CONTEXT: Non-steroidal anti-inflammatory (NSAID) agents are a widely utilized treatment for low back pain (LBP). Literature on NSAID use in articular cartilage has shown detrimental effects; however, minimal data exist to detail the effects of NSAIDs in intervertebral disc degeneration (IDD). As IDD is a major cause of LBP, we explored the effects of indomethacin, a commonly used NSAID, on disc matrix homeostasis in an animal model of IDD. PURPOSE: To determine the effects of oral indomethacin administration on IDD in an in vivo rabbit model...
April 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28410566/biomechanical-effect-of-interspinous-process-distraction-height-after-lumbar-fixation-surgery-an-in-vitro-model
#10
Lin Fu, Jianxiong Ma, Bin Lu, Haobo Jia, Jie Zhao, Mingjie Kuang, Rui Feng, Liyan Xu, Haohao Bai, Lei Sun, Ying Wang, Xinlong Ma
Pedicle screw fixation may induce abnormal activity at adjacent segment and accelerate the degeneration of lumbar vertebrae. Dynamic stabilizers could provide an intermediate solution between conservative treatment and fusion surgery. Lumbar vertebral segment cephalad to instrumented fixation was the most common localization of adjacent segment degeneration. The aim of this study is to explore the use of interspinous process devices in the lumbar vertebral segment cephalad to fixation segment in changing the mechanical distribution and limiting abnormal activity of the spine...
April 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28410358/reactivation-of-herpes-zoster-keratitis-with-corneal-perforation-after-zoster-vaccination
#11
Andre Jastrzebski, Seymour Brownstein, Setareh Ziai, Solin Saleh, Kay Lam, W Bruce Jackson
PURPOSE: We present a case of reactivated herpes zoster keratouveitis of 6 years duration with corneal perforation requiring penetrating keratoplasty shortly after inoculation with herpes zoster vaccine (Zostavax, Merck, Quebec, Canada). METHODS: Retrospective case report. RESULTS: A 67-year-old woman with a 5-year history of recurrent unilateral herpes zoster keratouveitis in her right eye presented with another recurrence 2 weeks after Zostavax vaccination...
April 12, 2017: Cornea
https://www.readbyqxmd.com/read/28404644/preprotein-mature-domains-contain-translocase-targeting-signals-that-are-essential-for-secretion
#12
Katerina E Chatzi, Marios Frantzeskos Sardis, Alexandra Tsirigotaki, Marina Koukaki, Nikolina Šoštarić, Albert Konijnenberg, Frank Sobott, Charalampos G Kalodimos, Spyridoula Karamanou, Anastassios Economou
Secretory proteins are only temporary cytoplasmic residents. They are typically synthesized as preproteins, carrying signal peptides N-terminally fused to their mature domains. In bacteria secretion largely occurs posttranslationally through the membrane-embedded SecA-SecYEG translocase. Upon crossing the plasma membrane, signal peptides are cleaved off and mature domains reach their destinations and fold. Targeting to the translocase is mediated by signal peptides. The role of mature domains in targeting and secretion is unclear...
April 12, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28382238/evaluation-and-interventional-management-of-pain-after-vertebral-augmentation-procedures
#13
Jesse Hatgis, Michelle Granville, Robert E Jacobson
INTRODUCTION: A small subset of patients who underwent successful vertebral compression fracture (VCF) augmentation procedures may develop subsequent pain requiring spinal injections. In a retrospective analysis, we determined whether the pain was related to the original fracture site or to another area within the lumbar or thoracic spine. The pain occurred either at the same/adjacent level and/or non-adjacent level as the VCF. Interventional treatments primarily targeted the facet joints, specifically in the form of facet joint blocks and/or radiofrequency ablation to the medial branches...
February 28, 2017: Curēus
https://www.readbyqxmd.com/read/28379575/no-transfer-of-pressure-to-adjacent-discs-during-human-low-pressure-controlled-discography-a-prospective-clinical-study
#14
Jan Willem Kallewaard, José W Geurts, Michel Terheggen, Chris Terwiel, Alfons Kessels, Maarten van Kleef, Paul C Willems
Background. : A substantial part of low back pain (LBP) originates from degeneration of the intervertebral disc. To confirm the diagnosis of discogenic pain, provocation discography seems the best available tool. However, provocation discography is also considered to be a controversial and subjective test because the patient's personal pain response is the most crucial for the result of the test. Recently, an in vivo porcine study and a study in nine human subjects showed passing of pressure to the adjacent discs during discography...
April 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28365433/percutaneous-endoscopic-cervical-discectomy-pecd-an-analysis-of-outcome-causes-of-reoperation
#15
Hyeong Seok Oh, Byeong Wook Hwang, Sang Joon Park, Chang Sheng Hsieh, Sang Ho Lee
OBJECTIVE: Percutaneous endoscopic cervical discectomy (PECD) regarded as an effective treatment modality in cervical disc herniation, including radicular pain and lateral location of disc herniation. This study aimed to evaluate the clinical and radiological outcomes with PECD, along with the causes of reoperation and the technique itself. METHODS: Between January 2007 and November 2012, 101 patients underwent PECD at the Busan Wooridul hospital. Three patients underwent two-level PECD...
March 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28362238/supratentorial-cavernous-malformations-adjacent-to-the-corticospinal-tract-surgical-outcomes-and-predictive-value-of-diffusion-tensor-imaging-findings
#16
Yuanxiang Lin, Fuxin Lin, Dezhi Kang, Yuming Jiao, Yong Cao, Shuo Wang
OBJECTIVE Diffusion tensor imaging (DTI) findings may facilitate clinical decision making in patients with supratentorial cavernous malformations adjacent to the corticospinal tract (CST-CMs). The objective of this study was to determine the predictive value of preoperative DTI findings for surgical outcomes in patients with CST-CMs. METHODS A prospectively maintained database of patients with CM referred to the authors' hospital between September 2012 and October 2015 was reviewed to identify all consecutive surgically treated patients with CST-CM...
March 31, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28355743/-topping-off-surgery-versus-double-segment-fusion-for-treatment-of-lumbar-degenerative-disease-with-mid-long-term-follow-up
#17
X L Chen, Y Hai, L Guan, Y Z Liu, J C Yang, Q J Su, N Kang, X L Meng, L Yang, Y Wang
Objective: To compare the mid-long term clinical effect of Topping-off surgery and lumbar fusion surgery for two-segmental lumbar degenerative disease. Methods: From March 2009 to March 2012, one hundred and twenty-six consecutive patients (Topping-off surgery and two-segment PLIF surgery) were studied in Orthopedics Department, Beijing Chao-Yang Hospital, Capital Medical University.The VAS and ODI were used to assess clinical symptoms.All patients underwent flexion/extension radiographs examinations before surgery, 1, 2 years and last follow-up postoperatively...
March 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28340364/cervical-facet-force-analysis-after-disc-replacement-versus-fusion
#18
Vikas V Patel, Zachary R Wuthrich, Kirk C McGilvray, Matthew C Lafleur, Emily M Lindley, Derrick Sun, Christian M Puttlitz
BACKGROUND: Cervical total disc replacement was developed to preserve motion and reduce adjacent-level degeneration relative to fusion, yet concerns remain that total disc replacement will lead to altered facet joint loading and long-term facet joint arthrosis. This study is intended to evaluate changes in facet contact force, pressure and surface area at the treated and superior adjacent levels before and after discectomy, disc replacement, and fusion. METHODS: Ten fresh-frozen human cadaveric cervical spines were potted from C2 to C7 with pressure sensors placed into the facet joints of C3-C4 and C4-C5 via slits in the facet capsules...
March 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28338454/impact-of-preoperative-diagnosis-on-patient-satisfaction-following-lumbar-spine-surgery
#19
Charles H Crawford, Leah Y Carreon, Mohamad Bydon, Anthony L Asher, Steven D Glassman
OBJECTIVE Patient satisfaction is a commonly used metric in the current health care environment. While factors that affect patient satisfaction following spine surgery are complex, the authors of this study hypothesized that specific diagnostic groups of patients are more likely to be satisfied after spine surgery and that this is reflected in patient-reported outcome measures. The purpose of this study was to determine if the preoperative diagnosis-disc herniation, stenosis, spondylolisthesis, adjacent segment degeneration, or mechanical disc collapse-would impact patient satisfaction following surgery...
March 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28337412/differential-involvement-of-corticospinal-tract-cst-fibers-in-umn-predominant-als-patients-with-or-without-cst-hyperintensity-a-diffusion-tensor-tractography-study
#20
Venkateswaran Rajagopalan, Erik P Pioro
Diagnosis of amyotrophic lateral sclerosis (ALS) depends on clinical evidence of combined upper motor neuron (UMN) and lower motor neuron (LMN) degeneration, although ALS patients can present with features predominantly of one or the other. Some UMN-predominant patients show hyperintense signal along the intracranial corticospinal tract (CST) on T2- and proton density (PD)-weighted images (ALS-CST +), and appear to have faster disease progression when compared to those without CST hyperintensity (ALS-CST -)...
2017: NeuroImage: Clinical
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