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https://www.readbyqxmd.com/read/28081241/cd25-cd127-foxp3-cells-represent-a-major-subpopulation-of-cd8-t-cells-in-the-eye-chambers-of-normal-mice
#1
Tomasz Maślanka, Natalia Ziółkowska, Hubert Ziółkowski, Joanna Małaczewska
The aim of this study has been to determine whether eye chambers constitute part of the normal migratory pathway of naive CD4+ and CD8+ T cells in mouse and if natural CD4+CD25+Foxp3+ and CD8+CD25+Foxp3+ regulatory T cells are present within these eye compartments. To this aim, the cells obtained from aqueous humor (AH) of normal mice were phenotyped in terms of the expression CD4, CD8, CD25, CD127 and transcription factor Foxp3. The mean percentage of CD8+ T cells in the total AH lymphocyte population was as high as 28...
2017: PloS One
https://www.readbyqxmd.com/read/28065449/a-specific-immune-tolerance-toward-offspring-cells-is-to-exist-after-the-mother-lymphocyte-infusion
#2
Haizhou Xing, Shiqin Liu, Xue Chen, Fang Fang, Xueqiang Wu, Ping Zhu
PURPOSE: To examine immune tolerance between maternal lymphocytes and offspring tissue after a donor lymphocyte infusion. METHODS: Mouse models were established by mating female BALB/c mice with male C57BL mice. Splenic lymphocytes from donors of different genetic backgrounds were labeled with carboxyfluorescein succinimidyl ester (CFSE), and 1×10(7) of the labeled cells were intravenously injected into a recipient. At 6h, 24h, 72h and 120h after the infusion, mononuclear cells in recipient spleen, liver, thymus, lymph nodes, and peripheral blood were collected...
December 26, 2016: Immunobiology
https://www.readbyqxmd.com/read/28043029/cd4-il-21-t-cells-are-correlated-with-regulatory-t-cells-and-il-21-promotes-regulatory-t-cells-survival-during-hiv-infection
#3
Zi-Ning Zhang, Li-Xin Bai, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang
INTRODUCTION: IL-21 enhances T and natural killer cells survival and antiviral functions without promoting T cell activation during HIV infection, which makes it a better adjuvant in anti-HIV immunotherapy. Due to the pleiotropy and redundancy of cytokines, it is vital to have a comprehensive knowledge of the role of IL-21 in the regulation of immune responses. Regulatory T cells (Tregs) play an important role in immune regulation and are a determinant of immune therapeutic efficacy in certain circumstances...
December 30, 2016: Cytokine
https://www.readbyqxmd.com/read/28035765/risk-stratification-of-adult-t-cell-leukemia-lymphoma-using-immunophenotyping
#4
Huseini H Kagdi, Maria A Demontis, Paul A Fields, Juan Carlos Ramos, Charles R M Bangham, Graham P Taylor
Adult T-cell leukemia/lymphoma (ATL), a human T-lymphotropic virus type 1 (HTLV-1)-associated disease, has a highly variable clinical course and four subtypes with therapeutic and prognostic implications. However, there are overlapping features between ATL subtypes and between ATL and nonmalignant (non-ATL) HTLV-1 infection complicating diagnosis and prognostication. To further refine the diagnosis and prognosis of ATL, we characterized the immunophenotype of HTLV-1-infected cells in ATL and non-ATL. A retrospective study of peripheral blood samples from 10 HTLV-1-uninfected subjects (UI), 54 HTLV-1-infected patients with non-ATL, and 22 with ATL was performed using flow cytometry...
December 30, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/28012777/sequential-administration-of-a-mva-based-muc1-cancer-vaccine-and-the-tlr9-ligand-litenimod-li28-improves-local-immune-defense-against-tumors
#5
Emmanuelle Schaedler, Christelle Remy-Ziller, Julie Hortelano, Nadine Kehrer, Marie-Christine Claudepierre, Tanja Gatard, Christopher Jakobs, Xavier Préville, Antoine F Carpentier, Karola Rittner
TG4010 is an immunotherapeutic vaccine based on Modified Vaccinia virus Ankara (MVA) encoding the human tumor-associated antigen MUC1 and human IL-2. In combination with first-line standard of care chemotherapy in advanced metastatic non-small-cell lung cancer (NSCLC), repeated subcutaneous injection of TG4010 improved progression-free survival in phase 2b clinical trials. In preclinical tumor models, MVATG9931, the research version of TG4010, conferred antigen-specific responses against the weak antigen human MUC1...
December 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27981723/microrna-155-is-a-biomarker-of-t-cell-activation-and-immune-dysfunction-in-hiv-1-infected-patients
#6
C Jin, L Cheng, S Höxtermann, T Xie, X Lu, H Wu, A Skaletz-Rorowski, N H Brockmeyer, N Wu
OBJECTIVES: MicroRNA-155 (miR-155) regulates T-cell differentiation and activation. It has also been associated with HIV infection. However, it remains unclear whether miR-155 is related to the T-cell response in HIV-infected individuals (e.g. T-cell activation and exhaustion). METHODS: We performed a cross-sectional study involving 121 HIV-1-infected patients on highly active antiretroviral therapy (HAART) and 43 HAART-naïve patients. MiR-155 levels in the peripheral blood were determined by quantitative reverse transcription-polymerase chain reaction (PCR)...
December 16, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27974111/-expression-of-regulatory-t-cells-and-natural-killer-t-cells-in-peripheral-blood-of-children-with-wilms-tumor
#7
Jing Chen, Tao Lin
OBJECTIVE: To study the changes and clinical significance of CD4(+)CD25(+)CD127(low) regulatory T cells (Treg) and CD3(+)CD16(+)CD56(+) natural killer T cells (NKT) in peripheral blood of children with Wilms tumor. METHODS: Twenty-one children with Wilms tumor were enrolled as the case group, and twenty-one healthy children for physical examinations were enrolled as the control group. Flow cytometry was used to detect the levels of CD4(+)CD25(+)CD127(low) T cells and CD3(+)CD16(+)CD56(+) T cells in peripheral blood of two groups...
December 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27956610/neutrophils-induce-proangiogenic-t-cells-with-a-regulatory-phenotype-in-pregnancy
#8
Suchita Nadkarni, Joanne Smith, Amanda N Sferruzzi-Perri, Agata Ledwozyw, Madhav Kishore, Robert Haas, Claudio Mauro, David J Williams, Sandra H P Farsky, Federica M Marelli-Berg, Mauro Perretti
Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the induction of a population of CD4(+) T cells displaying a GARP(+)CD127(lo)FOXP3(+) phenotype following antigen activation. Neutrophil-induced T (niT) cells produce IL-10, IL-17, and VEGF and promote vessel growth in vitro...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27942984/lps-treated-bone-marrow-derived-dendritic-cells-induce-immune-tolerance-through-modulating-differentiation-of-cd4-regulatory-t-cell-subpopulations-mediated-by-3g11-and-cd127
#9
Fang Zhou, Guang-Xian Zhang, Abdolmohamad Rostami
Intravenous transfer of LPS-treated bone marrow-derived dendritic cells blocks development of autoimmunity induced by CD4(+) T cells in vivo. However, cellular mechanisms of dendritic cell-mediated immune tolerance have not yet been fully elucidated. Here, we report that there are two new subpopulations of CD4(+)CD25(+)FoxP3(+)GITR(+) regulatory T cells (CD127(+)3G11(+) and CD127(+)3G11(-) cells). LPS-treated dendritic cells facilitate development of CD4(+)CD127(+)3G11(-) regulatory T cells but inhibit that of CD4(+)CD127(+)3G11(+) regulatory T cells...
December 12, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27941430/long-term-persistence-of-innate-lymphoid-cells-in-the-gut-after-intestinal-transplantation
#10
Joshua Weiner, Julien Zuber, Brittany Shonts, Suxiao Yang, Jianing Fu, Mercedes Martinez, Donna Farber, Tomoaki Kato, Megan Sykes
BACKGROUND: Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation has not been described. METHODS: Intestinal samples were taken from 4 isolated intestine (ITx) and 3 multivisceral (MvTx) transplant recipients at the time of any operative resection, such as stoma closure or revision. ILCs were isolated and analyzed by flow cytometry. The target population was defined as being negative for lineage markers and double-positive for CD45/CD127...
December 8, 2016: Transplantation
https://www.readbyqxmd.com/read/27931084/association-of-higher-cd4-cd25-high-cd127-low-foxp3-and-il-2-t-cell-frequencies-early-after-lung-transplantation-with-less-chronic-lung-allograft-dysfunction-at-two-years
#11
J Salman, F Ius, A-K Knoefel, W Sommer, Th Siemeni, C Kuehn, I Tudorache, M Avsar, T Nakagiri, G Preissler, R Hatz, M Greer, T Welte, A Haverich, G Warnecke
Regulatory T cells (Treg) can regulate alloantigens and may counteract chronic lung allograft dysfunction (CLAD) in lung transplantation. We analyzed Treg in peripheral blood prospectively and correlated percentages of subpopulations with the incidence of CLAD at two years. Among lung-transplanted patients between 01/2009 and 07/2011, only patients with sufficient Treg measurements were included into the study. Tregs were measured immediately before lung transplantation, at 3 weeks and 3, 6, 12 and 24 months after transplantation and were defined as CD4(+) CD25(high) T cells and further analyzed for CTLA4, CD127, FoxP3 and IL-2 expressions...
December 8, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27925643/primary-and-secondary-hemophagocytic-lymphohistiocytosis-have-different-patterns-of-t-cell-activation-differentiation-and-repertoire
#12
Sandra Ammann, Kai Lehmberg, Udo Zur Stadt, Gritta Janka, Anne Rensing-Ehl, Christian Klemann, Maximilian Heeg, Sebastian Bode, Ilka Fuchs, Stephan Ehl
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome characterized by hyperactivation of lymphocytes and histiocytes. T cells play a key role in HLH pathogenesis, but their differentiation pattern is not well characterized in patients with active HLH. We compared T-cell activation patterns between patients with familial HLH (1°HLH), 2°HLH without apparent infectious trigger (2°HLH) and 2°HLH induced by a viral infection (2°V-HLH). Polyclonal CD8(+) T cells are highly activated in 1°HLH and 2°V-HLH, but less in 2°HLH as assessed by HLA-DR expression and marker combination with CD45RA, CCR7, CD127, PD-1 and CD57...
December 7, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27912146/inosine-acedoben-dimepranol-promotes-an-early-and-sustained-increase-in-the-natural-killer-cell-component-of-circulating-lymphocytes-a-clinical-trial-supporting-anti-viral-indications
#13
S Rumel Ahmed, Amy S Newman, James O'Daly, Sean Duffy, Gillian Grafton, Catherine A Brady, S John Curnow, Nicholas M Barnes, John Gordon
Inosine Acedoben Dimepranol (IAD), licensed for the treatment of cell-mediated immune deficiencies associated with viral infections, has been reported to impact a variety of immune parameters both in vitro and in vivo. Here we report the results from a clinical trial where multiple lymphocyte subsets - CD19+ B cells, CD3+ T cells, CD4+ T-helper cells, FoxP3(hi)/CD25(hi)/CD127(lo) regulatory T cells (Tregs), CD3-/CD56+ NK cells, and CD3+/CD56+ NKT cells - were, together with serum immunoglobulins and IgG subclasses, followed during 14days of IAD administration to ten healthy volunteers; these selected from 27 individuals pre-screened in vitro for their capacity to respond to IAD as gauged by increases in the percentage of Treg and/or NKT cells arising in PHA-stimulated cultures...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27911806/permissive-roles-of-cytokines-interleukin-7-and-flt3-ligand-in-mouse-b-cell-lineage-commitment
#14
Lilly von Muenchow, Llucia Alberti-Servera, Fabian Klein, Giuseppina Capoferri, Daniela Finke, Rhodri Ceredig, Antonius Rolink, Panagiotis Tsapogas
Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating environmental signals to developing hematopoietic cells are cytokines, which regulate commitment of hematopoietic progenitors to the different blood lineages by acting either in an instructive or a permissive manner. Fms-like tyrosine kinase-3 (Flt3) ligand (FL) and Interleukin-7 (IL-7) are cytokines pivotal for B-cell development, as manifested by the severely compromised B-cell development in their absence...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27903296/factors-affecting-long-term-efficacy-of-t-regulatory-cell-based-therapy-in-type-1-diabetes
#15
Natalia Marek-Trzonkowska, Małgorzata Myśliwiec, Dorota Iwaszkiewicz-Grześ, Mateusz Gliwiński, Ilona Derkowska, Magdalena Żalińska, Maciej Zieliński, Marcelina Grabowska, Hanna Zielińska, Karolina Piekarska, Anna Jaźwińska-Curyłło, Radosław Owczuk, Agnieszka Szadkowska, Krystyna Wyka, Piotr Witkowski, Wojciech Młynarski, Przemysława Jarosz-Chobot, Artur Bossowski, Janusz Siebert, Piotr Trzonkowski
BACKGROUND: Recent studies suggest that immunotherapy using T regulatory cells (Tregs) prolongs remission in type 1 diabetes (T1DM). Here, we report factors that possibly affect the efficacy of this treatment. METHODS: The metabolic and immune background of 12 children with recently diagnosed T1DM, as well as that of untreated subjects, during a 2-year follow-up is presented. Patients were treated with up to 30 × 10(6)/kg b.w. of autologous expanded CD3(+)CD4(+)CD25(high)CD127(-) Tregs...
December 1, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27880974/deep-sequencing-of-the-tcrb-repertoire-of-human-foxp3-and-foxp3-t-cells-suggests-that-they-are-completely-distinct-and-non-overlapping
#16
Amit Golding, Samuel Darko, William H Wylie, Daniel C Douek, Ethan M Shevach
Maintenance of peripheral tolerance requires a balance between auto-reactive conventional T cells (Tconv) and thymically-derived Foxp3(+) regulatory T cells (tTregs). Considerable controversy exists regarding the similarities/differences in TCR repertoires expressed by Tconv and tTregs. We generated highly purified populations of human adult and cord blood Tconv and tTregs based on the differential expression of CD25 and CD127. The purity of the sorted populations was validated by intracellular staining for Foxp3 and Helios...
November 23, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27866241/elevated-regulatory-t-cells-surface-and-intracellular-ctla-4-expression-and-interleukin-17-in-the-lung-cancer-microenvironment-in-humans
#17
Iwona Kwiecien, Anna Stelmaszczyk-Emmel, Malgorzata Polubiec-Kownacka, Dariusz Dziedzic, Joanna Domagala-Kulawik
Regulatory T cells (Tregs) play an important role in the suppression of the immune response in lung cancer. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) expressed on T lymphocytes is capable of downregulating cytotoxic T cells and is constitutively expressed on Tregs. Little is known about the population of Tregs with two forms of CTLA-4: surface (s) and intracellular (in) in the lung cancer environment. Th17 cells defined by production of IL-17 have pleiotropic functions in anticancer immune response. Our aim was to detect the elements of immune response regulation in lung cancer in three compartments: by analysis of bronchoalveolar lavage fluid (BALF) from the lung affected by cancer (clBALF), healthy symmetrical lung (hlBALF) and peripheral blood (PB) from the same patient...
November 19, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27862137/t-cell-responses-and-regulation-and-the-impact-of-in-vitro-il-10-and-tgf-%C3%AE-modulation-during-treatment-of-active-tuberculosis
#18
Siri L Feruglio, Dag Kvale, Anne Ma Dyrhol-Riise
Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defense mechanism. In the present study we investigated T cell responses and regulation in active TB patients with drug-sensitive Mtb (n=18) during 24 weeks of efficient anti-TB therapy. T cell activation, differentiation, regulatory T cell (Treg) subsets, Mtb induced T cell proliferation and in vitro IL-10 and TGF-β modulation were analysed by flow cytometry at baseline and after 8 and 24 weeks of therapy, while soluble cytokines in culture supernatants were analysed by a 9-plex Luminex assay...
November 18, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27822211/cd4-t-follicular-helper-and-iga-b-cell-numbers-in-gut-biopsies-from-hiv-infected-subjects-on-antiretroviral-therapy-are-similar-to-hiv-uninfected-individuals
#19
John Zaunders, Mark Danta, Michelle Bailey, Gerald Mak, Katherine Marks, Nabila Seddiki, Yin Xu, David J Templeton, David A Cooper, Mark A Boyd, Anthony D Kelleher, Kersten K Koelsch
BACKGROUND: Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4(+) T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4(+) subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV(+) subjects on suppressive ART compared to HIV-negative controls (HNC)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27821506/a-subset-of-virus-specific-cd161-t-cells-selectively-express-the-multidrug-transporter-mdr1-and-are-resistant-to-chemotherapy-in-aml
#20
Abdullah Alsuliman, Muharrem Muftuoglu, Ahmad Khoder, Yong-Oon Ahn, Rafet Basar, Michael R Verneris, Pawel Muranski, A John Barrett, Enli Liu, Li Li, Kate Stringaris, Darius Armstrong-James, Hila Shaim, Kayo Kondo, Nobuhiko Imahashi, Borje Andersson, David Marin, Richard E Champlin, Elizabeth J Shpall, Katayoun Rezvani
The establishment of long-lived pathogen-specific T-cells is a fundamental property of the adaptive immune response. However, the mechanisms underlying long-term persistence of antigen-specific CD4(+) T-cells are not well-defined. Here we identify a subset of memory CD4(+) T-cells capable of effluxing cellular toxins, including rhodamine (Rho), through the multidrug efflux protein MDR1 (also known as P-glycoprotein and ABCB1). Drug-effluxing CD4(+) T-cells were characterized as CD161(+)CD95(+)CD45RA(-)CD127(hi)CD28(+)CD25(int) cells with distinct chemokine profile and a Th1-polarized pro-inflammatory phenotype...
November 7, 2016: Blood
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