keyword
MENU ▼
Read by QxMD icon Read
search

CD127

keyword
https://www.readbyqxmd.com/read/29768737/providence-of-cd25-kir-cd127-foxp3-cd8-t-cell-subset-determines-the-dynamics-of-tumor-immune-surveillance
#1
Sreeparna Chakraborty, Pushpak Bhattacharjee, Abir K Panda, Kirti Kajal, Sayantan Bose, Gaurisankar Sa
CD8+ T-regulatory cells are progressively emerging as crucial components of immune system. The previous report suggests the presence of FOXP3-positive CD8+ Treg cells, similar to CD4+ Tregs, in cancer patients which produce high levels of IL10 and TGFβ for its immunosuppressive activities. At an early stage of tumor development, we have identified a subset of FOXP3-negative CD8+ CD25+ KIR+ CD127- a Treg-like subset which is essentially IFNγ-positive. However, this early induced CD8+ CD25+ CD127- T cell subset certainly distinct from the IFNγ+ CD8+ T-effecter cells...
May 16, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29749506/cd8-t-cells-with-high-tgf%C3%A2-%C3%AE-1-expression-cause-lymph-node-fibrosis-following-hiv-infection
#2
Lei Huang, Jianning Deng, Wen Xu, Hongbo Wang, Lei Shi, Fengyao Wu, Dan Wu, Weimin Nei, Min Zhao, Panyong Mao, Xianzhi Zhou
Lymph node (LN) fibrosis resulting in cluster of differentiation (CD) 4+ T cell reduction following human immunodeficiency virus (HIV) infection is an important step in the pathogenesis of acquired immunodeficiency syndrome. The mechanisms mediating LN fibrosis following HIV infection have not been completely elucidated. In order to investigate the mechanism of LN fibrosis, the expression of transforming growth factor (TGF)‑β1 was determined in the LNs of HIV‑infected individuals by immunohistochemistry and fluorescence‑based flow cytometry...
May 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29734222/progressive-lentivirus-infection-induces-natural-killer-cell-receptor-expressing-b-cells-in-the-gastrointestinal-tract
#3
Cordelia Manickam, Chiadika Nwanze, Daniel R Ram, Spandan V Shah, Scott Smith, Rhianna Jones, Brady Hueber, Kyle Kroll, Valerie Varner, Paul Goepfert, Stephanie Jost, R Keith Reeves
OBJECTIVE: Recently, a seemingly novel innate immune cell subset bearing features of natural killer and B cells was identified in mice. So-called NKB cells appear as first responders to infections, but whether this cell population is truly novel or is in fact a subpopulation of B cells and exists in higher primates remains unclear. The objective of this study was to identify NKB cells in primates and study the impact of HIV/SIV infections. DESIGN AND METHODS: NKB cells were quantified in both naïve and lentivirus infected rhesus macaques and humans by excluding lineage markers (CD3, CD127), and positive Boolean gating for CD20, NKG2A/C and/or NKp46...
May 3, 2018: AIDS
https://www.readbyqxmd.com/read/29655570/interleukin-7-enhances-anti-tumor-activity-of-cd8-t-cells-in-patients-with-hepatocellular-carcinoma
#4
Dengke Teng, Lei Ding, Bo Cai, Qiang Luo, Hui Wang
Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals were enrolled. IL-7 expression and its receptor α chain CD127 level was measured. The regulatory activity of IL-7 to peripheral and liver-resident CD8+ T cells was investigated in co-culture systems which were directly or indirectly contacted with HCC cell line HepG2 in vitro...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29625390/dysfunction-of-regulatory-t-cells-in-patients-with-ankylosing-spondylitis-is-associated-with-a-loss-of-tim-3
#5
Mingfei Wang, Chengyi Liu, Allen Bond, Jun Yang, Xu Zhou, Jian Wang, Bin Ji
An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. In AS patients, the frequency of CD4+ CD25+ Foxp3+ CD127- Treg cells was slightly increased compared to healthy controls, but the level of Foxp3 MFI in AS patient CD4+ CD25+ Foxp3+ CD127- Treg cells was significantly lower than that in healthy control CD4+ CD25+ Foxp3+ CD127- Treg cells...
April 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29602245/reactive-glia-promote-development-of-cd103-cd69-cd8-t-cells-through-programmed-cell-death-ligand-1-pd-l1
#6
Sujata Prasad, Shuxian Hu, Wen S Sheng, Priyanka Chauhan, James R Lokensgard
INTRODUCTION: Previous work from our laboratory has demonstrated in vivo persistence of CD103+ CD69+ brain resident memory CD8+ T-cells (bTRM ) following viral infection, and that the PD-1: PD-L1 pathway promotes development of these TRM cells within the brain. Although glial cells express low basal levels of PD-L1, its expression is upregulated upon IFN-γ-treatment, and they have been shown to modulate antiviral T-cell effector responses through the PD-1: PD-L1 pathway. METHODS: We performed flow cytometric analysis of cells from co-cultures of mixed glia and CD8+ T-cells obtained from wild type mice to investigate the role of glial cells in the development of bTRM ...
March 30, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29593715/comparative-analysis-of-the-regulatory-t-cells-dynamics-in-peripheral-blood-in-human-and-porcine-polytrauma
#7
Rafael Serve, Ramona Sturm, Lukas Schimunek, Philipp Störmann, David Heftrig, Michel P J Teuben, Elsie Oppermann, Klemens Horst, Roman Pfeifer, Tim P Simon, Yannik Kalbas, Hans-Christoph Pape, Frank Hildebrand, Ingo Marzi, Borna Relja
Background: Severely injured patients experience substantial immunological stress in the aftermath of traumatic insult, which often results in systemic immune dysregulation. Regulatory T cells (Treg) play a key role in the suppression of the immune response and in the maintenance of immunological homeostasis. Little is known about their presence and dynamics in blood after trauma, and nothing is known about Treg in the porcine polytrauma model. Here, we assessed different subsets of Treg in trauma patients (TP) and compared those to either healthy volunteers (HV) or data from porcine polytrauma...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29566311/il-7-suppresses-macrophage-autophagy-and-promotes-liver-pathology-in-schistosoma-japonicum-infected-mice
#8
Jifeng Zhu, Weiwei Zhang, Lina Zhang, Lei Xu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Ming Xiao, Hui Bai, Feng Liu, Chuan Su
In schistosomiasis japonica and mansoni, parasite eggs trapped in host liver elicit severe liver granulomatous inflammation that subsequently leads to periportal fibrosis, portal hypertension, haemorrhage or even death. Macrophages are critical for granuloma formation and the development of liver fibrosis during schistosomiasis. However, whether the aberrant regulation of macrophage autophagy has an effect on the development of liver immunopathology in schistosomiasis remains to be elucidated. In this study, we showed that Schistosoma japonicum (S...
March 22, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29564420/irf4-modulates-cd8-t-cell-sensitivity-to-il-2-family-cytokines
#9
Su Huang, Yingjia Shen, Duy Pham, Li Jiang, Zheng Wang, Mark H Kaplan, Guangjun Zhang, Jie Sun
IFN regulatory factor 4 (IRF4) is a key transcription factor that promotes effector CD8+ T cell differentiation and expansion. The roles of IRF4 in regulating the CD8+ T cell response to cytokines have not been explored. In this article, we show that IL-2 and IL-15 signaling and STAT5 activation regulate IRF4 expression in CD8+ T cells. Gene-expression profile analysis has also revealed that IRF4 is required for expression of the receptors of IL-2 family cytokines CD122 and CD127. We found that IRF4 binds directly to CD122 and CD127 gene loci, indicating that it may directly promote CD122 and CD127 gene transcription...
August 1, 2017: ImmunoHorizons
https://www.readbyqxmd.com/read/29560431/cd4-t-cells-react-to-local-increase-of-%C3%AE-synuclein-in-a-pathology-associated-variant-dependent-manner-and-modify-brain-microglia-in-absence-of-brain-pathology
#10
Mads N Olesen, Josefine R Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death. This suggests that the immune system is able to react differently to the different stages of α-synuclein pathology. However, it was unclear whether these immune changes were governed by brain processes or by a direct immune response to α-synuclein modifications. We have herein locally increased the peripheral concentration of α-synuclein or its pathology-associated variants, nitrated or fibrillar, to characterize the modulation of the CD4 T cell pool by α-synuclein and brain microglia in the absence of any α-synuclein brain pathology...
January 2018: Heliyon
https://www.readbyqxmd.com/read/29560282/vaccination-route-can-significantly-alter-the-innate-lymphoid-cell-subsets-a-feedback-between-il-13-and-ifn-%C3%AE
#11
Zheyi Li, Ronald J Jackson, Charani Ranasinghe
This study demonstrates that the fate of a vaccine is influenced by the cytokines produced by the innate lymphoid cells (ILC) recruited to the vaccination site, and it is vaccine route and adjuvant dependent. Intranasal virus vaccination induced ST2/IL-33R+ ILC2 in lung, while intramuscular vaccination induced exclusively IL-25R+ ILC2 in muscle. Interestingly, a larger proportion of IL-13+ ILC2s were detected in muscle following i.m. viral vector vaccination compared to lung post i.n. delivery. These observations revealed that ILC2 were the main source of IL-13 at the vaccination site (24 h post vaccination) responsible for inducing T cells of varying avidities...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29515766/cell-banking-for-regulatory-t-cell-based-therapy-strategies-to-overcome-the-impact-of-cryopreservation-on-the-treg-viability-and-phenotype
#12
Karolina Gołąb, Randall Grose, Veronica Placencia, Amittha Wickrema, Julia Solomina, Martin Tibudan, Evelyn Konsur, Kamil Ciepły, Natalia Marek-Trzonkowska, Piotr Trzonkowski, J Michael Millis, John Fung, Piotr Witkowski
The first clinical trials with adoptive Treg therapy have shown safety and potential efficacy. Feasibility of such therapy could be improved if cells are cryopreserved and stored until optimal timing for infusion. Herein, we report the evaluation of two cell-banking strategies for Treg therapy: 1) cryopreservation of CD4+ cells for subsequent Treg isolation/expansion and 2) cryopreservation of ex-vivo expanded Tregs (CD4+ CD25hi CD127lo/- cells). First, we checked how cryopreservation affects cell viability and Treg markers expression...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29511064/mass-cytometry-reveals-innate-lymphoid-cell-differentiation-pathways-in-the-human-fetal-intestine
#13
Na Li, Vincent van Unen, Thomas Höllt, Allan Thompson, Jeroen van Bergen, Nicola Pezzotti, Elmar Eisemann, Anna Vilanova, Susana M Chuva de Sousa Lopes, Boudewijn P F Lelieveldt, Frits Koning
Innate lymphoid cells (ILCs) are abundant in mucosal tissues and involved in tissue homeostasis and barrier function. Although several ILC subsets have been identified, it is unknown if additional heterogeneity exists, and their differentiation pathways remain largely unclear. We applied mass cytometry to analyze ILCs in the human fetal intestine and distinguished 34 distinct clusters through a t-SNE-based analysis. A lineage (Lin)- CD7+ CD127- CD45RO+ CD56+ population clustered between the CD127+ ILC and natural killer (NK) cell subsets, and expressed diverse levels of Eomes, T-bet, GATA3, and RORγt...
May 7, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29467598/an-attempt-to-induce-an-immunomodulatory-effect-in-rowers-with-spirulina-extract
#14
RANDOMIZED CONTROLLED TRIAL
Artur Juszkiewicz, Piotr Basta, Elżbieta Petriczko, Bogusław Machaliński, Jerzy Trzeciak, Karolina Łuczkowska, Anna Skarpańska-Stejnborn
Background: The aim of this study was to analyze the response of selected components of the immune system in rowers to maximal physical exercise, and to verify if this response can be modulated by supplementation with spirulina (cyanobacterium Spirulina platensis ) . Method: The double-blind study included 19 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group ( n  = 10), receiving 1500 mg of spirulina extract for 6 weeks, or to the placebo group ( n  = 9)...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29457302/innate-lymphoid-cells-at-the-human-maternal-fetal-interface-in-spontaneous-preterm-labor
#15
Yi Xu, Roberto Romero, Derek Miller, Pablo Silva, Bogdan Panaitescu, Kevin R Theis, Afrah Arif, Sonia S Hassan, Nardhy Gomez-Lopez
PROBLEM: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor. METHODS OF STUDY: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls...
February 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29453928/cd4-cd25-cd127low-foxp3-regulatory-t-cells-in-crohn-s-disease
#16
Ali Khalili, Soheil Ebrahimpour, Iradj Maleki, Saeid Abediankenari, Mousa Mohammadnia Afrouzi
BACKGROUND: Regulatory T (Treg) cell play a key role in autoimmune diseases. We evaluated the regulatory function and frequency of Treg cells and secreted IL-10, IL-35 concentration in Crohn's disease (CD). METHODS: Twenty-three patients with CD and 25 healthy controls (HC) were included in this study. We analysed the alteration of Tregs frequency using flow cytometry for CD4, CD25, CD127 and FoxP3 markers. Surface expression of CD4, CD25 and CD127 markers were used for isolation of a relatively pure Treg cells...
February 16, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29449864/seasonal-variation-in-circulating-group-2-innate-lymphoid-cells-in-mugwort-allergic-asthmatics-during-and-outside-pollen-season
#17
Qing Miao, Yan Wang, Yong-Ge Liu, Yi-Xin Ren, Hui Guan, Zhen Li, Wei Xu, Li Xiang
Background: Group 2 innate lymphoid cells (ILC2s) are a newly identified cell population with the potent capability to produce Th2-type cytokines in a non-antigen specific manner. Previous study demonstrated that enhanced circulating ILC2s in cat-allergic patient after experimental allergen challenge, whereas the effects of natural allergen exposure on peripheral ILC2s are still unclear. We therefore examined the variations in circulating ILC2s among asthmatic patients sensitized to different allergens in- and outside- pollen season...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29444931/complete-remission-with-reduction-of-high-risk-clones-following-haploidentical-nk-cell-therapy-against-mds-and-aml
#18
Andreas T Björklund, Mattias Carlsten, Ebba Sohlberg, Lisa L Liu, Trevor Clancy, Mohsen Karimi, Sarah Cooley, Jeffrey S Miller, Monika Klimkowska, Marie Schaffer, Emma Watz, Kristina Wikström, Pontus Blomberg, Björn Engelbrekt Wahlin, Marzia Palma, Lotta Hansson, Per Ljungman, Eva Hellström-Lindberg, Hans-Gustaf Ljunggren, Karl-Johan Malmberg
Purpose: To evaluate the safety, efficacy, and immunobiological correlates of allogeneic NK-cell-based therapy in primary chemotherapy-refractory or relapsed high-risk myelodysplastic syndrome (MDS), secondary AML (MDS/AML), and de novo AML patients. Experimental Design: Sixteen patients received fludarabine/cyclophosphamide conditioning combined with total lymphoid irradiation followed by adoptive immunotherapy with IL2-activated haploidentical NK cells. Results: NK-cell infusions were well-tolerated, with only transient adverse events observed in the 16 patients...
April 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29423061/chronic-activation-profile-of-circulating-cd8-t-cells-in-s%C3%A3-zary-syndrome
#19
Marina Passos Torrealba, Kelly Cristina Manfrere, Denis R Miyashiro, Josenilson F Lima, Luana de M Oliveira, Nátalli Z Pereira, Jade Cury-Martins, Juliana Pereira, Alberto J S Duarte, Maria N Sato, José A Sanches
Sézary syndrome (SS) is a leukemic variant of cutaneous T cell lymphoma (CTCL), and the neoplastic CD4+ T cells of SS patients undergo intense clonal proliferation. Although Sézary cells have been studied extensively, studies on adaptive immunity regarding CD8+T cells are scarce. This study aimed to investigate activation marker expression in CD8+ T cells according to the differentiation stages and IL-7/IL7Rα axis responses of patients with SS. Moreover, this study aimed to verify the soluble forms of CD38, sCD127 and IL-7 in serum...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29388481/chemotherapy-alters-the-increased-numbers-of-myeloid-derived-suppressor-and-regulatory-t-cells-in-children-with-acute-lymphoblastic-leukemia
#20
Mohamed Labib Salem, Mohamed R El-Shanshory, Said H Abdou, Mohamed S Attia, Shymaa M Sobhy, Mona F Zidan, Abdel-Aziz A Zidan
INTRODUCTION: Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The precise mechanism behind the relapse in this disease is not clearly known. One possible mechanism could be the accumulation of immunosuppressive cells, including myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs ) which we and others have reported to mediate suppression of anti-tumor immune responses. AIM: In this study, we aimed to analyze the numbers of these cells in a population of B-ALL pediatric patients...
April 2018: Immunopharmacology and Immunotoxicology
keyword
keyword
56267
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"