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https://www.readbyqxmd.com/read/29904949/combination-with-mir-124a-improves-the-protective-action-of-bmscs-in-rescuing-injured-rat-podocytes-from-abnormal-apoptosis-and-autophagy
#1
Jiping Sun, Jing Lv, Wenjing Zhang, Lili Li, Jia Lv, Yingzhou Geng, Aiping Yin
This in vitro study was performed to identify the role of miR-124a in bone marrow stromal stem cells (BMSCs) therapy for H2 O2 -induced rat podocyte injury, and determine whether combination treatment with miR-124a could improve the protective effect of BMSCs. Cell viability of podocytes was detected by CCK-8 assay. Detection of ROS level, apoptotic rate, and autophagy rate was carried out using flow cytometry assays. Oxidative stress parameters were analyzed using the ELISA assays. MiR-124a and mRNA levels were determined using real-time PCR...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904922/sideroxylin-callistemon-lanceolatus-suppressed-cell-proliferation-and-increased-apoptosis-in-ovarian-cancer-cells-accompanied-by-mitochondrial-dysfunction-the-generation-of-reactive-oxygen-species-and-an-increase-of-lipid-peroxidation
#2
Sunwoo Park, Whasun Lim, Wonsik Jeong, Fuller W Bazer, Dongho Lee, Gwonhwa Song
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells)...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29899688/magnesium-ions-inhibit-the-expression-of-tumor-necrosis-factor-%C3%AE-and-the-activity-of-%C3%AE-secretase-in-a-%C3%AE-amyloid-protein-dependent-mechanism-in-app-ps1-transgenic-mice
#3
Xin Yu, Pei-Pei Guan, Di Zhu, Yun-Yue Liang, Tao Wang, Zhan-You Wang, Pu Wang
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. The neuropathological features of AD are the aggregation of extracellular amyloid β-protein (Aβ) and tau phosphorylation. Recently, AD was found to be associated with magnesium ion (Mg2+ ) deficit and tumor necrosis factor-alpha (TNF-α) elevation in the serum or brains of AD patients. To study the relationship between Mg2+ and TNF-α, we used human- or mouse-derived glial and neuronal cell lines or APP/PS1 transgenic (Tg) mice as in vitro and in vivo experimental models, respectively...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29890546/transcriptomic-analysis-of-the-association-between-diabetes-mellitus-and-myocardial-infarction
#4
Lijuan Song, Wenjun You, Peng Wang, Feng Li, Huakun Liu
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for coronary artery disease (CAD), and the complications of CAD are the leading cause of deaths among people with DM. Herein, this study aims to identify the common genes and pathways between diabetes and myocardial infarction (MI) to provide more clues for the related mechanism studies. METHODS: Differentially expressed genes (DEGs) were identified using the cutoff (|log2(fold change)|>0.45 and P value<0...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29887959/tanshinone-iia-attenuates-osteoclastogenesis-in-ovariectomized-mice-by-inactivating-nf-kb-and-akt-signaling-pathways
#5
Li Cheng, Shengyuan Zhou, Yin Zhao, Yanqing Sun, Zheng Xu, Bo Yuan, Xiongsheng Chen
Osteoporosis is a common disease associated with age and menopausal status. Postmenopausal osteoporosis is the most common type of primary osteoporosis and is accompanied by increased risk of osteoporotic fracture. Natural and herbal compounds have long been used to prevent and treat many human diseases. Here, we demonstrated that tanshinone IIA prevented ovariectomy-induced bone loss in an in vivo mouse model that closely mimics osteoporosis. In addition, we found that tanshinone IIA inhibited the receptor activator of nuclear factor NF-κB ligand (RANKL)-induced osteoclast differentiation and osteoclastogenesis in vitro ...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29883845/solvent-free-and-one-pot-synthesis-of-silver-and-zinc-nanoparticles-activity-toward-cell-membrane-component-and-insulin-signaling-pathway-in-experimental-diabetes
#6
Jihan Hussein, Mehrez E El Naggar, Yasmin Abdel Latif, Dalia Medhat, Mona El Bana, Eman Refaat, Safaa Morsy
OBJECTIVE: To investigate and compare between the effect of both silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) on insulin signaling pathway and insulin sensitivity in experimental diabetes. Preparation of AgNPs and ZnONPs in their solid state were carried out using pullulan (Natural polymer) as both reducing and stabilizing agent. The synthesis of thesenanoparticles in a large scale were carried out without using any solvents. The experimental male albino rats received diluted solutions of AgNPs and ZNONPs...
May 31, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29877241/-chronic-lymphocytic-leukemia-update-on-pathophysiology-and-management
#7
Junji Suzumiya
Chronic lymphocytic leukemia (CLL) is the most common hematological malignancy in the Western countries. Although a multi-step model has been proposed for the pathogenesis of CLL as well as other malignancies, the precise mechanism underlying the development of CLL remains complicated and unclear. In addition, several studies have investigated adverse prognostic factors, including gene abnormalities and the evolution of clones with the disease progression. FCR (fludarabine, cyclophosphamide, and rituximab) has been the standard first-line therapy for "fit" younger patients without TP53 abnormality/17p deletion...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29872394/astragaloside-iv-attenuated-3-4-benzopyrene-induced-abdominal-aortic-aneurysm-by-ameliorating-macrophage-mediated-inflammation
#8
Jiaoni Wang, Yingying Zhou, Shaoze Wu, Kaiyu Huang, Saroj Thapa, Luyuan Tao, Jie Wang, Yigen Shen, Jinsheng Wang, Yangjing Xue, Kangting Ji
Abdominal aortic aneurysm (AAA), characterized by macrophage infiltration-mediated inflammation and oxidative stress, is a potentially fatal disease. Astragaloside IV (AS-IV) has been acknowledged to exhibit antioxidant and anti-inflammatory properties. This study was designed to investigate the protective effect of AS-IV against AAA formation induced by 3,4-benzopyrene (Bap) and angiotensin II (Ang II), and to explore probable mechanisms. Results showed that AS-IV decreased AAA formation, and reduced macrophage infiltration and expression of matrix metalloproteinase...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29870666/method-for-dynamically-detecting-secretions-from-single-cells-using-a-nanopore
#9
Eamonn Kennedy, Mohammad Hokmabadi, Zhuxin Dong, Kim McKelvey, Edward M Nelson, Gregory Timp
Secreted proteins mediate cell-to-cell communications. Thus, eavesdropping on the secretome could reveal the cellular phenotype, but it is challenging to detect the proteins because they are secreted only in minute amounts and then diluted in blood plasma or contaminated by cell culture medium or the lysate. In this pilot study, it is demonstrated that secretions from single cancer cells can be detected and dynamically analyzed through measurements of blockades in the electrolytic current due to single molecules translocating through a nanopore in a thin inorganic membrane...
June 5, 2018: Nano Letters
https://www.readbyqxmd.com/read/29852247/nuclear-accumulation-of-ship1-mutants-derived-from-aml-patients-leads-to-increased-proliferation-of-leukemic-cells
#10
Marcus M Nalaskowski, Patrick Ehm, Christoph Rehbach, Nina Nelson, Maike Täger, Kathrin Modest, Manfred Jücker
The inositol 5-phosphatase SHIP1 acts as negative regulator of intracellular signaling in myeloid cells and is a tumor suppressor in myeloid leukemogenesis. After relocalization from the cytoplasm to the plasma membrane SHIP1 terminates PI3-kinase mediated signaling processes. Furthermore, SHIP1 is also found in distinct puncta in the cell nucleus and nuclear SHIP1 has a pro-proliferative function. Here we report the identification of five nuclear export signals (NESs) which regulate together with the two known nuclear localization signals (NLSs) the nucleocytoplasmic shuttling of SHIP1...
May 28, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29847659/neurofibromin-deficiency-induces-endothelial-cell-proliferation-and-retinal-neovascularization
#11
Hanfang Zhang, Farlyn Z Hudson, Zhimin Xu, Rebekah Tritz, Modesto Rojas, Chintan Patel, Stephen B Haigh, Zsuzsanna Bordán, David A Ingram, David J Fulton, Neal L Weintraub, Ruth B Caldwell, Brian K Stansfield
Purpose: Neurofibromatosis type 1 (NF1) is the result of inherited mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. Eye manifestations are common in NF1 with recent reports describing a vascular dysplasia in the retina and choroid. Common features of NF1 retinopathy include tortuous and dilated feeder vessels that terminate in capillary tufts, increased endothelial permeability, and neovascularization. Given the retinal vascular phenotype observed in persons with NF1, we hypothesize that preserving neurofibromin may be a novel strategy to control pathologic retinal neovascularization...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29842900/%C3%AE-lipoic-acid-attenuates-oxidative-stress-and-neurotoxicity-via-the-erk-akt-dependent-pathway-in-the-mutant-hsod1-related-drosophila-model-and-the-nsc34-cell-line-of-amyotrophic-lateral-sclerosis
#12
Tianhang Wang, Jiling Cheng, Shuyu Wang, Xudong Wang, Hongquan Jiang, Yueqing Yang, Ying Wang, Chunting Zhang, Weiwei Liang, Honglin Feng
Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA) is a natural, universal antioxidant capable of scavenging hydroxyl radicals as well as regenerating a series of antioxidant enzymes that has been widely used in clinical settings. This study aimed to evaluate the antioxidant and neuroprotective effects of LA in ALS cell and Drosophila models with mutant G85R and G93A hSOD1 genes...
May 26, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29807069/fasudil-hydrochloride-ameliorates-memory-deficits-in-rat-model-of-streptozotocin-induced-alzheimer-s-disease-involvement-of-pi3-kinase-enos-and-nf%C3%AE%C2%BAb
#13
Manish Kumar, Nitin Bansal
Restoration of PI3-kinase signaling portrays therapeutic potential in Alzheimer's disease (AD). Hyperactive Rho-kinase in AD negatively modulates PI3-kinase pathway, thereby cause cognitive decline. Fasudil is a Rho-kinase inhibitor that has shown therapeutic benefits in brain disorders. The present study is aimed to decipher the role of PI3-kinase pathway in neuroprotective activity of fasudil using STZ-ICV model of AD. MWM and NORT showed that fasudil (300 µg/kg, ICV) averted the STZ-ICV (3 mg/kg) induced memory dysfunctions in rats...
May 25, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29799846/comprehensive-analysis-of-t-cell-leukemia-signals-reveals-heterogeneity-in-the-pi3-kinase-akt-pathway-and-limitations-of-pi3-kinase-inhibitors-as-monotherapy
#14
Olga Ksionda, Marsilius Mues, Anica M Wandler, Lisa Donker, Milou Tenhagen, Jesse Jun, Gregory S Ducker, Ksenia Matlawska-Wasowska, Kevin Shannon, Kevan M Shokat, Jeroen P Roose
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial toxicity and more specific therapies targeting the underlying molecular lesions are highly desired. Perturbed Ras signaling is prevalent in T-ALL and occurs via oncogenic RAS mutations or through overexpression of the Ras activator RasGRP1 in ~65% of T-ALL patients. Effective small molecule inhibitors for either target do not currently exist. Genetic and biochemical evidence link phosphoinositide 3-kinase (PI3K) signals to T-ALL, PI3Ks are activated by Ras-dependent and Ras-independent mechanisms, and potent PI3K inhibitors exist...
2018: PloS One
https://www.readbyqxmd.com/read/29791756/interactions-between-insulin-and-diet-on-striatal-dopamine-uptake-kinetics-in-rodent-brain-slices
#15
Jyoti C Patel, Melissa A Stouffer, Maria Mancini, Charles Nicholson, Kenneth D Carr, Margaret E Rice
Diet influences dopamine transmission in motor- and reward-related basal ganglia circuitry. In part, this reflects diet-dependent regulation of circulating and brain insulin levels. Activation of striatal insulin receptors amplifies axonal dopamine release in brain slices, and regulates food preference in vivo. The effect of insulin on dopamine release is indirect, and requires striatal cholinergic interneurons that express insulin receptors. However, insulin also increases dopamine uptake by promoting dopamine transporter (DAT) surface expression, which counteracts enhanced dopamine release...
May 23, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29790605/cd57-identifies-t-cells-with-functional-senescence-before-terminal-differentiation-and-relative-telomere-shortening-in-patients-with-activated-pi3-kinase-delta-syndrome
#16
Paola Cura Daball, Monica Sofia Ventura Ferreira, Sandra Ammann, Christian Klemann, Myriam Ricarda Lorenz, Ursula Warthorst, T Ronan Leahy, Niall Conlon, Justin Roche, Pere Soler-Palacín, Marina Garcia-Prat, Ilka Fuchs, Sebastian Fuchs, Fabian Beier, Tim H Brümmendorf, Carsten Speckmann, Peter Olbrich, Olaf Neth, Klaus Schwarz, Stephan Ehl, Anne Rensing-Ehl
Premature T cell immunosenescence with CD57+ CD8+ T cell accumulation has been linked to immunodeficiency and autoimmunity in primary immunodeficiencies including activated PI3 kinase delta syndrome (APDS). To address whether CD57 marks the typical senescent T cell population seen in adult individuals or identifies a distinct population in APDS, we compared CD57+ CD8+ T cells from mostly pediatric APDS patients to those of healthy adults with similarly prominent senescent T cells. CD57+ CD8+ T cells from APDS patients were less differentiated with more CD27+ CD28+ effector memory cells showing increased PD1 and Eomesodermin expression...
May 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29789375/neurotrophin-responsiveness-of-sympathetic-neurons-is-regulated-by-rapid-mobilization-of-the-p75-receptor-to-the-cell-surface-through-trka-activation-of-arf6
#17
F Edward Hickman, Emily M Stanley, Bruce D Carter
The p75 neurotrophin receptor (p75NTR) plays an integral role in patterning the sympathetic nervous system during development. Initially, p75NTR is expressed at low levels as sympathetic axons project toward their targets, which enables neurotrophin-3 (NT3) to activate TrkA receptors and promote growth. Upon reaching nerve growth factor (NGF) producing tissues, p75NTR is up regulated resulting in formation of TrkA-p75 complexes, which are high affinity binding sites selective for NGF, thereby blunting NT3 signaling...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29782313/kainic-acid-impairs-the-memory-behavior-of-app23-mice-by-increasing-brain-amyloid-load-through-a-tumor-necrosis-factor-%C3%AE-dependent-mechanism
#18
Yang Ruan, Shi-Jie Guo, Xu Wang, Dong Dong, Dong-Hui Shen, Jie Zhu, Xiang-Yu Zheng
Kainic acid (KA) was recently identified as an epileptogenic and neuroexcitotoxic agent that is responsible for inducing learning and memory deficits in various neurodegenerative diseases, such as Alzheimer's disease (AD). However, the mechanism by which KA acts upon AD remains unclear. To this end, we presently investigated the roles of KA in processing amyloid-β protein precursor (AβPP) and amyloid-β protein (Aβ) loads during the course of AD development and progression. Specifically, KA treatment clearly caused the upregulation of tumor necrosis factor α (TNF-α) via activation of the PI3-K/AKT, ERK1/2, and p65 pathways in glial cells...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29778748/protein-kinases-are-involved-in-the-cardioprotective-effects-activated-by-platelet-glycoprotein-iib-iiia-inhibitor-tirofiban-at-reperfusion-in-rats-in-vivo
#19
Shih-Tai Chang, Ya-Ting Yang, Chi-Ming Chu, Kuo-Li Pan, Jen-Te Hsu, Ju-Feng Hsiao, Yu-Sheng Lin, Chang-Min Chung
The thrombolytic effect of platelet glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa inhibitors) in myocardial infarction has been well established. Nevertheless, data on the mechanism of the cardioprotective effect of GP IIb/IIIa inhibitors in ischemic-reperfusion injury (IR) are lacking. Sprague-Dawley rats received 120min of coronary ischemia and 180min of reperfusion. A GP IIb/IIIa inhibitor was given via continuous intravenous infusion at a rate of 2 ug/kg/min 30min prior to reperfusion with/without inhibitors of PKCε (chelerythrine), PI3 kinase and Akt (wortmannin), p38 MAPK (SB203582), p42/44 MAPK (PD98059) and ERK1/2 (u0126) 15min prior to the GP IIb/IIIa inhibitor...
May 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29766336/ischaemic-preconditioning-protects-cardiomyocytes-from-anthracycline-induced-toxicity-via-the-pi3k-pathway
#20
Angshuman Maulik, Sean M Davidson, Izabela Piotrowska, Malcolm Walker, Derek M Yellon
PURPOSE: Anthracyclines cause chronic irreversible cardiac failure, but the mechanism remains poorly understood. Emerging data indicate that cardiac damage begins early, suggesting protective modalities delivered in the acute stage may confer prolonged benefit. Ischaemic preconditioning (IPC) activates the pro-survival reperfusion injury salvage kinase (RISK) pathway which involves PI3-kinase and MAPK/ERK1/2. METHODS: We investigated whether simulated IPC (sIPC), in the form of a sublethal exposure to a hypoxic buffer simulating ischaemic conditions followed by reoxygenation, protects primary adult rat cardiomyocytes against anthracycline-induced injury...
May 15, 2018: Cardiovascular Drugs and Therapy
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