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https://www.readbyqxmd.com/read/28228749/neuroprotective-role-of-the-pi3-kinase-akt-signaling-pathway-in-zebrafish
#1
Shuang Chen, Yunzhang Liu, Xiaozhi Rong, Yun Li, Jianfeng Zhou, Ling Lu
Neuronal survival and growth in the embryo is controlled partly by trophic factors. For most trophic factors (such as Insulin-like growth factor-1), the ability to regulate cell survival has been attributed to the phosphoinositide 3-kinase (PI3K)/Akt kinase cascade. This study presents data illustrating the role of PI3K/Akt in attainment of normal brain size during zebrafish embryogenesis. Blocking PI3K with inhibitor LY294002 caused a significant reduction in brain size (in addition to global growth retardation) during zebrafish embryogenesis...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28224334/the-trpm4-channel-is-functionally-important-for-the-beneficial-cardiac-remodeling-induced-by-endurance-training
#2
Mélanie Gueffier, Justin Zintz, Karen Lambert, Amanda Finan, Franck Aimond, Nourdine Chakouri, Christophe Hédon, Mathieu Granier, Pierre Launay, Jérôme Thireau, Sylvain Richard, Marie Demion
Cardiac hypertrophy (CH) is an adaptive process that exists in two distinct forms and allows the heart to adequately respond to an organism's needs. The first form of CH is physiological, adaptive and reversible. The second is pathological, irreversible and associated with fibrosis and cardiomyocyte death. CH involves multiple molecular mechanisms that are still not completely defined but it is now accepted that physiological CH is associated more with the PI3-K/Akt pathway while the main signaling cascade activated in pathological CH involves the Calcineurin-NFAT pathway...
February 21, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28191283/active-%C3%AE-catenin-is-regulated-by-the-pten-pi3-kinase-pathway-a-role-for-protein-phosphatase-pp2a
#3
Amit Persad, Geetha Venkateswaran, Li Hao, Maria E Garcia, Jenny Yoon, Jaskiran Sidhu, Sujata Persad
Dysregulation of Wnt/β-catenin signaling has been associated with the development and progression of many cancers. The stability and subcellular localization of β-catenin, a dual functional protein that plays a role in intracellular adhesion and in regulating gene expression, is tightly regulated. However, little is known about the transcriptionally active form of β-catenin, Active Beta Catenin (ABC), that is unphosphorylated at serine 37 (Ser37) and threonine 41 (Thr41). Elucidating the mechanism by which β-catenin is activated to generate ABC is vital to the development of therapeutic strategies to block β-catenin signaling for cancer treatment...
November 2016: Genes & Cancer
https://www.readbyqxmd.com/read/28187039/plasma-neutrophil-elastase-and-elafin-as-prognostic-biomarker-for-acute-respiratory-distress-syndrome-a-multicenter-survival-and-longitudinal-prospective-observation-study
#4
Zhaozhong Zhu, Tiehua Wang, Zhuang Liu, Liang Yi, Zhixu Yang, Weishuai Bian, Wei Chen, Shupeng Wang, Gang Li, Ang Li, Greg S Martin, Xi Zhu
BACKGROUND: Neutrophil elastase (HNE) is a destructive enzyme and plays crucial roles in the pathophysiology of acute respiratory distress syndrome (ARDS). Endogenous proteinase inhibitors elafin (PI3) is important to protect against lung tissue destruction. We proposed to examine whether HNE and PI3 serve as prognostic biomarkers for ARDS. METHODS: This study is a survival and longitudinal analysis of plasma profiles of HNE and PI3 in ARDS patients from a multi-center prospective observational cohort in Beijing, China...
February 9, 2017: Shock
https://www.readbyqxmd.com/read/28173836/complex-regulation-of-neutrophil-derived-mmp-9-secretion-in-central-nervous-system-tuberculosis
#5
Catherine W M Ong, Przemyslaw J Pabisiak, Sara Brilha, Poonam Singh, Federico Roncaroli, Paul T Elkington, Jon S Friedland
BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is associated with neurological deficit and death. The mechanisms by which neutrophils drive TB-associated CNS matrix destruction are not clearly defined. METHODS: Human brain biopsies with histologically proven CNS-TB were stained for neutrophils, neutrophil elastase, and MMP-9...
February 7, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28162105/molecular-insights-into-cancer-therapeutic-effects-of-the-dietary-medicinal-phytochemical-withaferin-a
#6
Chandra Sekhar Chirumamilla, Claudina Pérez-Novo, Xaveer Van Ostade, Wim Vanden Berghe
Despite the worldwide research efforts to combat cancer, it remains a leading cause of death. Although various specific kinase inhibitors already have been approved for clinical cancer treatment, occurrence of intrinsic or acquired resistance and intermittent response over longer periods limits long-term success of single kinase-targeted therapies. In this respect, there is a renewed interest in polypharmaceutical natural compounds, which simultaneously target various hyperactivated kinases involved in tumour-inflammation, angiogenesis, cell survival, proliferation, metastasis and angiogenesis...
February 6, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28161437/tissue-organization-alters-gene-expression-in-equine-induced-trophectoderm-cells
#7
Brad M Reinholt, Jennifer S Bradley, Robert D Jacobs, Alan D Ealy, Sally E Johnson
Rapid morphological and gene expression changes occur during the early formation of a mammalian blastocyst. Critical to successful retention of the blastocyst and pregnancy is a functional trophectoderm (TE) that supplies the developing embryo with paracrine factors and hormones. The contribution of TE conformational changes to gene expression was examined in equine induced trophoblast (iTr) cells. Equine iTr cells were cultured as monolayers or in suspension to form spheres. The spheres are hollow and structurally reminiscent of native equine blastocysts...
February 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28158914/effect-of-porcine-glucagon-like-peptides-2-on-tight-junction-in-glp-2r%C3%A2-%C3%A2-ipec-j2-cell-through-the-pi3-k-akt-mtor-p70-s6k-signalling-pathway
#8
K K Qi, Y Q Sun, J Wan, B Deng, X M Men, J Wu, Z W Xu
Because of rare glucagon-like peptide-2 (GLP-2) receptor (+) cells within the gut mucosa, the molecular mechanisms transducing the diverse actions of GLP-2 remain largely obscure. This research identified the naturally occurring intestinal cell lines that endogenously express GLP-2R and determined the molecular mechanisms of the protective effects of GLP-2-mediated tight junctions (TJ) in GLP-2R (+) cell line. (i) Immunohistochemistry results showed that GLP-2R is localised to the epithelia, laminae propriae and muscle layers of the small and large bowels of newborn piglets...
February 3, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28155013/targeted-therapy-in-chronic-lymphocytic-leukemia-cll
#9
REVIEW
Erin M Pettijohn, Shuo Ma
The standard of care for the treatment of chronic lymphocytic leukemia (CLL) has traditionally been chemoimmunotherapy. For patients who are unable to tolerate chemotherapy and those with high risk 17p deletions, there were previously few feasible or efficacious treatment options. Novel targeted agents for the treatment of CLL have the potential to offer long-term, durable remissions and offer promising treatment options for those in previously challenging population groups. Current targeted agents in CLL are directed against B cell receptor-associated tyrosine kinases such as BTK and SYK, the downstream PI3-kinase pathway, as well as the antiapoptotic protein BCL-2...
February 2, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28154937/spatiotemporal-expression-of-foxo4-foxo6a-and-foxo6b-in-the-developing-brain-and-retina-are-transcriptionally-regulated-by-pi3k-signaling-in-zebrafish
#10
Sheng-Jia Lin, Ming-Chang Chiang, Hung-Yu Shih, Kun-Chun Chiang, Yi-Chuan Cheng
The forkhead box subclass O (FoxO) family of proteins is a group of highly evolutionary conserved transcription factors that regulate various cellular processes and embryonic development. Dysregulated expressions of FOXO genes have been identified in numerous tumors and genetic disorders. The expression of FOXO/Foxo, particularly FOXO4/Foxo4 and FOXO6/Foxo6, in the developing nervous system has not been fully characterized. Here, we identified zebrafish foxo4, foxo6a, and foxo6b homologs and demonstrated that all three genes were expressed in the developing nervous system...
February 2, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28130256/ca2-calmodulin-dependent-protein-kinase-ii%C3%AE-and-ii%C3%AE-mediate-tgf%C3%AE-induced-transduction-of-fibronectin-and-collagen-in-human-pulmonary-fibroblasts
#11
Subhendu Mukherjee, Wei Sheng, Rui Sun, Luke J Janssen
It is now clear that in addition to activating several complex kinase pathways (Smad, MAP kinase, PI3 kinase), TGFβ also acts by elevating [Ca2+] within the cytosol of human pulmonary fibroblasts. Ca2+/calmodulin-dependent protein kinase II (CamK II) is also known to regulate gene expression in fibroblasts. In this study, we examined the interactions between calcium signaling, activation of CamK and other kinases, and extracellular matrix (ECM) gene expression. Human pulmonary fibroblasts were cultured and stimulated with artificially-generated Ca2+-pulses in the absence of TGFβ, or with TGFβ (1 nM) or vehicle in the presence of various blockers of Ca2+ signaling...
January 27, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28126840/neuroblast-niche-position-is-controlled-by-pi3-kinase-dependent-de-cadherin-adhesion
#12
Susan E Doyle, Matthew C Pahl, Karsten H Siller, Lindsay Ardiff, Sarah E Siegrist
Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. Yet how stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset of brain neuroblasts (NBs) in Drosophila utilize PI3-kinase and DE-cadherin to build adhesive contact for NB niche positioning. NBs remain within their native microenvironment when levels of PI3-kinase activity and DE-cadherin are elevated in NBs. This occurs through PI3-kinase dependent regulation of DE-Cadherin mediated cell adhesion between NBs and neighboring cortex glia, and between NBs and their GMC daughters...
January 26, 2017: Development
https://www.readbyqxmd.com/read/28126466/coconut-oil-protects-cortical-neurons-from-amyloid-beta-toxicity-by-enhancing-signaling-of-cell-survival-pathways
#13
F Nafar, J P Clarke, K M Mearow
Alzheimer's disease is a progressive neurodegenerative disease that has links with other conditions that can often be modified by dietary and life-style interventions. In particular, coconut oil has received attention as having potentially having benefits in lessening the cognitive deficits associated with Alzheimer's disease. In a recent report, we showed that neuron survival in cultures co-treated with coconut oil and Aβ was rescued compared to cultures exposed only to Aβ. Here we investigated treatment with Aβ for 1, 6 or 24 h followed by addition of coconut oil for a further 24 h, or treatment with coconut oil for 24 h followed by Aβ exposure for various periods...
January 23, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28122716/relaxin-confers-cytotrophoblast-protection-from-hypoxiareoxygenation-injury-through-the-phosphatidylinositol-3-kinase-akt-protein-kinase-b-cell-survival-pathway
#14
Oluseyi Ogunleye, Bertha Campo, Diana Herrera, Emiel D Post Uiterweer, Kirk P Conrad
Preeclampsia affects 3-5% of pregnancies, contributes to 10-15% of maternal mortality, and is a leading cause of prematurity and increased long-term morbidity in those affected. Contemporary understanding of preeclampsia's maternal-fetal interface suggests a major role for placental oxidative stress resulting from ischemia-reperfusion injury. We hypothesized the pregnancy hormone relaxin would reduce cytotrophoblast apoptosis, necrosis (aponecrosis) and export of placental debris into maternal circulation. If so, relaxin might be employed as a therapeutic intervention to diminish activation of the maternal systemic inflammatory response central to clinical disease development...
January 25, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28122362/regulation-of-oncogenic-pi3-kinase-signaling-by-jarid1b
#15
EDITORIAL
Nicole D Facompre, Kayla H Harmeyer, Devraj Basu
No abstract text is available yet for this article.
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28119233/loss-of-erbb2-pi3k-akt-signaling-prevents-zinc-pyrithione-induced-cardioprotection-during-ischemia-reperfusion
#16
Sandhya Thokala, Santhipriya Inapurapu, Vijaya Lakshmi Bodiga, Praveen Kumar Vemuri, Sreedhar Bodiga
OBJECTIVES: The purpose of this study was to determine if zinc homeostasis is affected during ischemia/reperfusion, if so, whether zinc pyrithione limits myocardial cell death and improves hemodynamics when administered as an adjunct to reperfusion and if ErbB receptor tyrosine kinases that are important for the long-term structural integrity of the heart are indispensable for reperfusion salvage. METHODS: Isolated perfused rat hearts were subjected to 35min of global ischemia and reperfused for 120min to determine the relative intracellular zinc levels by TSQ staining...
January 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28104969/assessment-of-a-clinical-pharmacy-activity-in-a-pediatric-inpatient-department-in-cote-d-ivoire
#17
Danho Pascal Abrogoua, César Pacôme Békégnran, Bi Marius Gro, Elisée Doffou, Madeleine Amorissani Folquet
BACKGROUND: Clinical pharmacy activities in a pediatric inpatient department help to improve the management of patients clinically and economically. OBJECTIVE: To assess the relevance of pharmaceutical interventions (PIs) in a pediatric inpatient department in Abidjan (Cote d'Ivoire). MATERIALS AND METHODS: We carried out a cross-sectional, descriptive study from February to September 2014. The information collected was classified according to the classification of drug-related problems (DRPs) and PIs of the French Society of Clinical Pharmacy...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28100485/quantification-of-growth-factor-signaling-and-pathway-crosstalk-by-live-cell-imaging
#18
Sean M Gross, Peter Rotwein
Peptide growth factors stimulate cellular responses through activation of their trans-membrane receptors. Multiple intracellular signaling cascades are engaged following growth factor - receptor binding, leading to short- and long-term biological effects. Each receptor-activated signaling pathway does not act in isolation, but rather interacts at different levels with other pathways to shape signaling networks that are distinctive for each growth factor. To gain insights into the specifics of growth factor-regulated interactions among different signaling cascades, we developed a HeLa cell line stably expressing fluorescent live-cell imaging reporters that are readouts for two major growth factor-stimulated pathways, Ras - Raf - Mek - Erk and PI3-kinase - Akt...
January 18, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28095750/effects-of-pre-germinated-brown-rice-treatment-high-fat-diet-induced-metabolic-syndrome-in-c57bl-6j-mice
#19
Hsueh-Wei Yen, Hui-Li Lin, Chi-Long Hao, Fu-Chih Chen, Chun-Yun Chen, Jia-Hao Chen, Kuo-Ping Shen
To investigate using pre-germinated brown rice (PGBR) to treat metabolic syndrome, we fed one group of mice standard-regular-diet (SRD) for 20 weeks and another group of mice high-fat-diet (HFD) for 16 weeks. We subdivided them into HFD group and HFD + PGBR group whose dietary carbohydrate was replaced with PGBR for 4 weeks. The HFD group gained more weight, had higher blood pressure, heart rate, blood glucose and lipids, liver levels of TG, feces TG and bile acid, lower adipose levels of adipocytokine, lower skeletal muscle IR, IRS-1, IRS-2, PI3 K, Akt/PKB, GLUT-1, GLUT-4, GCK and PPAR-γ; higher liver SREBP-1, SCD-1, FAS, HMGCR, LDLR, CYP7α1 and PPAR-α, and higher adipose SREBP-1, SCD-1, FAS, and lower adipose PPAR-α and adiponectin...
January 18, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28087538/bcap-inhibits-proliferation-and-differentiation-of-myeloid-progenitors-in-the-steady-state-and-during-demand-situations
#20
Jeffrey M Duggan, Matthew B Buechler, Rebecca M Olson, Tobias M Hohl, Jessica A Hamerman
B cell adaptor for PI3-kinase (BCAP) is a signaling adaptor expressed in mature hematopoietic cells including monocytes and neutrophils. Here we investigated the role of BCAP in the homeostasis and development of these myeloid lineages. BCAP(-/-) mice had more bone marrow (BM) monocytes than WT mice, and in mixed WT:BCAP(-/-) BM chimeras, monocytes and neutrophils skewed towards BCAP(-/-) origin, showing a competitive advantage for BCAP(-/-) myeloid cells. BCAP was expressed in bone marrow hematopoietic progenitors, including LSK (Lineage(-)Sca1(+)cKit(+)), CMP (Common Myeloid Progenitor) and GMP (Granulocyte/Macrophage Progenitor) cells...
January 13, 2017: Blood
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