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https://www.readbyqxmd.com/read/29048352/effects-of-short-term-probiotic-ingestion-on-immune-profiles-and-microbial-translocation-among-hiv-1-infected-vietnamese-children
#1
Azumi Ishizaki, Xiuqiong Bi, Lam Van Nguyen, Kazunori Matsuda, Hung Viet Pham, Chung Thi Thu Phan, Dung Thi Khanh Khu, Hiroshi Ichimura
Here, we investigated the effects of the probiotic strain Lactobacillus casei Shirota (LcS) on immune profiles and intestinal microbial translocation among children infected with human immunodeficiency virus (HIV). This prospective study included 60 HIV-infected children-including 31 without antiretroviral therapy (ART) (HIV(+)) and 29 who received ART for a median of 3.5 years (ART(+)) and 20 children without HIV infection (HIV(-)). Participants were recruited in Vietnam. All children were given fermented milk containing LcS (6...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29030488/long-lived-innate-il-17-producing-%C3%AE-%C3%AE-t-cells-modulate-antimicrobial-epithelial-host-defense-in-the-colon
#2
Abdul Rashid Bin Mohammad Muzaki, Irene Soncin, Yolanda Aphrilia Setiagani, Jianpeng Sheng, Piotr Tetlak, Klaus Karjalainen, Christiane Ruedl
Intestinal IL-17-producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17-producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon γ/δ T17 cells express, together with Vγ4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon γ/δ T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3γ and Reg3β...
October 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29021537/elevated-levels-of-ccr6-t-helper-22-cells-correlate-with-skin-and-renal-impairment-in-systemic-lupus-erythematosus
#3
Wei Zhong, Yanfang Jiang, Hongshuang Ma, Jiang Wu, Zhenyu Jiang, Ling Zhao
Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of pathological features. Our study investigated the potential role of CCR6(+) T cells in organ impairment of SLE patients. We analyzed CCR6(+/-) T cell subset populations and compared the concentrations of IL-22, IFN-γ, TNF-α, and IL-17A cytokines in 67 patients with newly diagnosed SLE and 26 healthy controls. We found that SLE patients had elevated percentages of CCR6(+) T, CCR6(+) Th22, Th17, Th17.1, and CCR6(-) Th2 cell subsets, along with increased concentrations of IL-22, IFN-γ, TNF-α, and IL-17 cytokines...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28988536/role-of-pka-and-pi3k-in-leptin-and-ghrelin-regulation-of-adaptive-subpopulations-of-regulatory-cd4-t-lymphocyte-formation
#4
E G Orlova, S V Shirshev
The role of phosphatidylinositol-3 kinase (PI3K) and protein kinase A (PKA) in leptin and ghrelin regulation of formation of adaptive (a) subpopulations of CD4+ T-lymphocytes (helper (h) cells producing interleukin-17A) (aTһ17) and of T-regulatory lymphocytes (aTreg) in the context of physiological pregnancy is established. It is shown that leptin at a concentration typical for the second half of pregnancy (trimesters II-III) enhances the differentiation of aTһ17 with a high level of interleukin-17A (IL-17A) production and the expression of the chemokine receptor CCR6 with the participation of PI3K...
September 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28972090/il-17-secreting-%C3%AE-%C3%AE-t-cells-are-completely-dependent-upon-ccr6-for-homing-to-inflamed-skin
#5
James J Campbell, Karen Ebsworth, Linda S Ertl, Jeffrey P McMahon, Dale Newland, Yu Wang, Shirley Liu, Zhenhua Miao, Ton Dang, Penglie Zhang, Israel F Charo, Rajinder Singh, Thomas J Schall
mAbs that neutralize IL-17 or its receptor have proven efficacious in treating moderate-to-severe psoriasis, confirming IL-17 as an important driver of this disease. In mice, a rare population of T cells, γδT17 cells, appears to be a dominant source of IL-17 in experimental psoriasis. These cells traffic between lymph nodes and the skin, and are identified by their coexpression of the TCR variable regions γ4 and δ4. These cells are homologous to the Vγ9Vδ2 T cell population identified in human psoriatic plaques...
September 29, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28964722/a-t-cell-specific-deletion-of-hdac1-protects-against-experimental-autoimmune-encephalomyelitis
#6
Lisa Göschl, Teresa Preglej, Patricia Hamminger, Michael Bonelli, Liisa Andersen, Nicole Boucheron, Alexandra F Gülich, Lena Müller, Victoria Saferding, Ilgiz A Mufazalov, Kiyoshi Hirahara, Christian Seiser, Patrick Matthias, Thomas Penz, Michael Schuster, Christoph Bock, Ari Waisman, Günter Steiner, Wilfried Ellmeier
Multiple sclerosis (MS) is a human neurodegenerative disease characterized by the invasion of autoreactive T cells from the periphery into the CNS. Application of pan-histone deacetylase inhibitors (HDACi) ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model for MS, suggesting that HDACi might be a potential therapeutic strategy for MS. However, the function of individual HDAC members in the pathogenesis of EAE is not known. In this study we report that mice with a T cell-specific deletion of HDAC1 (using the Cd4-Cre deleter strain; HDAC1-cKO) were completely resistant to EAE despite the ability of HDAC1cKO CD4(+) T cells to differentiate into Th17 cells...
September 27, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28942020/cd25-expressing-th17-cells-mediate-cd8-t-cell-suppression-in-ctla-4-dependent-mechanisms-in-pancreatic-ductal-adenocarcinoma
#7
Cuicui Lang, Jinyan Wang, Lei Chen
The tumor-associated immune response is governed by the signalling events of various regulatory molecules, one of which is the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). In conventional T cells, CTLA-4 could outcompete CD28 in binding to CD80/86 but does not produce a co-stimulatory signal, resulting in T cell anergy. CTLA-4 in regulatory T cells (Tregs) could also function in a cell-extrinsic fashion by removing CD80/CD86 from the antigen-presenting cells (APCs), thus preventing further priming of other T cells...
September 20, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28939272/natural-and-induced-immunization-against-ccl20-ameliorate-experimental-autoimmune-encephalitis-and-may-confer-protection-against-multiple-sclerosis
#8
Michal Abraham, Arnon Karni, Karin Mausner-Fainberg, Ido D Weiss, Amnon Peled
Th-17 type immune response that occurs in multiple sclerosis (MS) is linked to CCR6-CCL20 interaction. We confirmed the dependency on CCR6 in EAE development. Vaccination of mice with hCCL20, but not mCCL20, produced anti-murine CCL20 and ameliorated EAE. The EAE clinical score negatively correlated with anti CCL20 levels. A beneficial effect was transferred by sera from hCCL20-immunized mice. Immunized mice with cyclic peptide that include a bacterial outer membrane protein A (ompA), that share homology sequence with hCCL20 produced anti CCL20, anti ompA and anti-cyclic peptide...
September 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28918288/th9-cells-promote-antitumor-immunity-via-il-9-and-il-21-and-demonstrate-atypical-cytokine-expression-in-breast-cancer
#9
Fa-Ping You, Jian Zhang, Tao Cui, Rui Zhu, Chong-Qing Lv, Hai-Tao Tang, Di-Wen Sun
Breast cancer is a major cause of cancer-related death in women. Antitumor T cell responses play critical therapeutic roles, including direct cytotoxicity mediated by CD8(+) T cells and immunomodulatory roles mediated by CD4(+) T cells. The IL-9-expressing Th9 cells are recently found to present antitumor immunity in melanoma and lung adenocarcinoma. In this study, we found that IL-9 expression in the serum and in circulating CD4(+) T cells were significantly upregulated in breast cancer patients compared to healthy controls...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28915559/zbtb1-controls-nkp46-ror-gamma-t-innate-lymphoid-cell-ilc3-development
#10
Ying Lu, Xianyu Zhang, Nicolas Bouladoux, Saransh Neel Kaul, Kangxin Jin, Derek Sant'Angelo, Yasmine Belkaid, Damian Kovalovsky
Innate lymphoid cells (ILCs) play a central role conferring protection at the mucosal frontier. In this study, we have identified a requirement of the transcription factor Zbtb1 for the development of RORγt(+) ILCs (ILC3s). Zbtb1-deficient mice lacked NKp46(+) ILC3 cells in the lamina propria of the small and large intestine. This requirement of Zbtb1 was cell intrinsic, as NKp46(+) ILC3s were not generated from Zbtb1-deficient progenitors in bone marrow chimeras and Zbtb1-deficient RORγt(+) CCR6(-)NKp46(-) ILC3s didn't generate NKp46(+) ILC3s in co-cultures with OP9-DL1 stroma...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912605/peripheral-human-cd4-cd8-t-lymphocytes-exhibit-a-memory-phenotype-and-enhanced-responses-to-il-2-il-7-and-il-15
#11
Marie-Laure Clénet, François Gagnon, Ana Carmena Moratalla, Emilie C Viel, Nathalie Arbour
CD4(+)CD8(+) T lymphocytes account for 1-2% of circulating human T lymphocytes, but their frequency is augmented in several diseases. The phenotypic and functional properties of these T lymphocytes are still ill-defined. We performed an ex vivo characterization of CD4(+)CD8(+) T lymphocytes from the blood of healthy individuals. We observed that CD4(+)CD8(+) T lymphocytes exhibit several characteristics associated with memory T lymphocytes including the expression of chemokine receptors (e.g. CCR7, CXCR3, CCR6) and activation markers (e...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910360/transgelin-2-is-upregulated-on-activated-b-cells-and-expressed-in-hyperplastic-follicles-in-lupus-erythematosus-patients
#12
Kaori Kiso, Hajime Yoshifuji, Takuma Oku, Masaki Hikida, Koji Kitagori, Yoshitaka Hirayama, Toshiki Nakajima, Hironori Haga, Tatsuaki Tsuruyama, Aya Miyagawa-Hayashino
Transgelin-2 (TAGLN2) is an actin-binding protein that controls actin stability and promotes T cell activation. TAGLN2 is also expressed on B-cells but its function in B-cells is unknown. We found that TAGLN2-expressing B-cells were localized in the germinal center (GC) of secondary lymphoid tissues and TAGLN2 mRNA was significantly upregulated after IgM+IgG stimulation in primary human B-cells, suggesting that TAGLN2 was upregulated upon B-cell activation. In support of this, lymph nodes (LNs) from patients with systemic lupus erythematosus (SLE), in which the intense GC activity have been recognized, showed increased TAGLN2 expression in B-cells compared to control LNs...
2017: PloS One
https://www.readbyqxmd.com/read/28903065/inflammation-polymorphisms-and-prostate-cancer-risk-in-jamaican-men-role-of-obesity-body-size
#13
Bhawna Dubey, Maria D Jackson, Charnita Zeigler-Johnson, Karthik Devarajan, Rafael E Flores-Obando, Norma McFarlane-Anderson, Marshall K Tulloch-Reid, William Aiken, Kevin Kimbro, Dominique Z Jones, LaCreis R Kidd, Camille Ragin
African ancestry and obesity are associated with higher risk of prostate cancer (PC). In a pilot study, we explored interactions between obesity (as measured by waist to hip ratio (WHR)) and inflammatory SNPs in relation to PC risk among Jamaican men. This study evaluated 87 chemokine and cytokine associated SNPs in obese and normal weight cases (N=109) and controls (N=102) using a stepwise penalized logistic regression approach in multivariable analyses. Upon stratification by WHR (normal weight (WHR<0...
December 15, 2017: Gene
https://www.readbyqxmd.com/read/28894259/cd161-identifies-polyfunctional-th1-th17-cells-in-the-genital-mucosa-that-are-depleted-in-hiv-infected-female-sex-workers-from-nairobi-kenya
#14
Geneviève Boily-Larouche, Kenneth Omollo, Julianna Cheruiyot, Jane Njoki, Makobu Kimani, Joshua Kimani, Julius Oyugi, Julie Lajoie, Keith R Fowke
CD161 identifies a subset of circulating Th17 cells that are depleted in the blood and gut of HIV-infected individuals. In the female reproductive tract (FRT), the pattern of CD161 expression on CD4(+) cells remains unknown. Here, we characterized CD161 expression in the FRT of Kenyan female sex workers (FSW). Compared to the blood, CD161(+)CD4(+) T cells were enriched in the FRT of uninfected FSWs. These cells were depleted in FRT of HIV-infected FSWs. Cervical CD161(+) cells harboured an activated phenotype (CD69, CD95, HLA-DR) with elevated expression of tissue-homing markers (CCR6, β7 integrin) and HIV co-receptor (CCR5)...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875388/intrinsic-renal-cells-induce-lymphocytosis-of-th22-cells-from-iga-nephropathy-patients-through-b7-ctla-4-and-ccl-ccr-pathways
#15
Lu Gan, Qiaoling Zhou, Xiaozhao Li, Chen Chen, Ting Meng, Jiaxi Pu, Mengyuan Zhu, Chenggen Xiao
IgA nephropathy (IgAN), the most common glomerulonephritis, has an unclear pathogenesis. The role of Th22 cells, which are intimately related to proteinuria and progression in IgAN, in mediating infection-related IgAN is unclear. This study aimed to characterize the association between intrinsic renal cells (tubular epithelial cells and mesangial cells) and Th22 cells in immune regulation of infection-related IgAN and to elucidate the impact of Th22 lymphocytosis; the proinflammatory cytokines IL-1, IL-6, and TNF-α; and CCL chemokines on kidney fibrosis...
September 5, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28873441/a-fully-humanized-igg-like-bispecific-antibody-for-effective-dual-targeting-of-cxcr3-and-ccr6
#16
Remy Robert, Laurent Juglair, Ee X Lim, Caroline Ang, Carl J H Wang, Gregor Ebert, Olan Dolezal, Charles R Mackay
Chemokines and their receptors are pivotal for the trafficking of leukocytes during immune responses, and host defense. However, immune cell migration also contributes to a wide variety of autoimmune and chronic inflammatory diseases. Compelling evidence suggests that both CXCR3 and CCR6 chemokine receptors play crucial roles in the migration of pathological Th1 and Th17 cells during the course of certain inflammatory diseases. The use of two or more receptors by pathogenic cells may explain why targeting of individual receptors has proven disappointing in the clinic...
2017: PloS One
https://www.readbyqxmd.com/read/28872971/phenotypic-and-functional-characteristics-of-th17-cd4-il17a-cells-in-human-oral-squamous-cell-carcinoma-and-its-clinical-relevance
#17
Poonam Gaur, Nootan K Shukla, Satya N Das
Recent studies have suggested an important role of T helper 17 (Th17) cells in tumor biology however, their phenotypic and functional aspects are poorly understood in context with oral cancer. We therefore, investigated the various phenotypic and functional markers of Th17 cells elucidating their relevance in oral squamous cell carcinoma (OSCC). Multi-color flow cytometry (FACs) was used to analyze the frequency and different markers of circulating Th17 cells ex vivo in peripheral blood mono-nuclear cells (PBMCs) from 69 OSCC patients and 35 healthy controls...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28870639/migratory-properties-of-ex-vivo-expanded-regulatory-t-cells-influence-of-all-trans-retinoic-acid-and-rapamycin
#18
J L Beermann, C T Thiesler, U Dringenberg, C Alter, S Kuhs, S Velaga, S N Ukena, A Franzke
Adoptively transferred regulatory T-cells represent a promising therapeutic approach for tolerance induction in autoimmunity and transplantation medicine. However, a major hurdle for clinical application is the manufacturing of sufficient Treg cell numbers with respect to the low frequency of naturally occurring Tregs in the peripheral blood. Therefore, ex vivo large-scale expansion is mandatory for most of the clinical conditions. Besides the Treg cell number other parameters of the cell product are of high relevance for safe and efficient clinical Treg cell application like Treg cell purity, suppressive capacity and genetic stability of the Treg cell phenotype...
September 1, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/28868359/immune-mediator-pharmacogenomics-tcl1a-snps-and-estrogen-dependent-regulation-of-inflammation
#19
Ming-Fen Ho, Richard M Weinshilboum
This review describes the important functional implications of TCL1A single nucleotide polymorphisms (SNPs) discovered during pharmacogenomic studies of aromatase inhibitor-induced musculoskeletal adverse events that were subsequently shown to influence the expression of cytokines, chemokines, toll-like receptors (TLR), and NF-κB in a SNP and estrogen-dependent fashion. Functional genomic studies of these SNPs led to the discovery of novel mechanisms that may contribute to disease pathophysiology and which may also increase our understanding of pharmacogenomic aspects of regulation of the expression of inflammatory mediators...
August 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28855314/il-1%C3%AE-and-il-23-promote-extrathymic-commitment-of-cd27-cd122-%C3%AE-%C3%AE-t-cells-to-%C3%AE-%C3%AE-t17-cells
#20
Andreas Muschaweckh, Franziska Petermann, Thomas Korn
γδT17 cells are a subset of γδ T cells committed to IL-17 production and are characterized by the expression of IL-23R and CCR6 and lack of CD27 expression. γδT17 cells are believed to arise within a narrow time window during prenatal thymic development. In agreement with this concept, we show in this study that adult Rag1(-/-) recipient mice of Il23r(gfp/+) (IL-23R reporter) bone marrow selectively lack IL-23R(+) γδT17 cells. Despite their absence in secondary lymphoid tissues during homeostasis, γδT17 cells emerge in bone marrow chimeric mice upon induction of skin inflammation by topical treatment with imiquimod cream (Aldara)...
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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