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https://www.readbyqxmd.com/read/29604056/cripto-promotes-an-aggressive-tumour-phenotype-and-resistance-to-treatment-in-hepatocellular-carcinoma
#1
Sofia Karkampouna, Danny van der Helm, Peter C Gray, Lanpeng Chen, Irena Klima, Jöel Grosjean, Mark C Burgmans, Arantza Farina-Sarasqueta, Ewa B Snaar-Jagalska, Deborah M Stroka, Luigi Terracciano, Bart van Hoek, Alexander F Schaapherder, Susan Osanto, George N Thalmann, Hein W Verspaget, Minneke J Coenraad, Marianna Kruithof-de Julio
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Despite increasing treatment options for this disease, prognosis remains poor. CRIPTO (TDGF1) protein is expressed at high levels in several human tumours and promotes oncogenic phenotype. Its expression has been correlated to poor prognosis in HCC. In this study, we aimed to elucidate the basis for the effects of CRIPTO in HCC. We investigated CRIPTO expression levels in three cohorts of clinical cirrhotic and HCC specimens...
March 31, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29594385/cripto-1-is-overexpressed-in-carcinoma-ex-pleomorphic-adenoma-of-salivary-gland
#2
Leorik Pereira Silva, Luiz Arthur Barbosa da Silva, Bruno Tavares Sedassari, Suzana Cantanhede Orsini Machado de Sousa, Joabe Dos Santos Pereira, Lélia Batista de Souza, Márcia Cristina da Costa Miguel
INTRODUCTION: Cripto-1 is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family. Besides being critical for early embryonic development, Cripto-1 is also associated with the development and behavior of several cancers. OBJECTIVE: We analyzed the immunoexpression of Cripto-1 in normal salivary glands (NSGs), pleomorphic adenomas (PAs), and carcinoma ex pleomorphic adenomas (CaExPAs) of salivary glands. METHODS: A total of 12 NSGs, 16 PAs and 12 CaExPAs underwent immunohistochemical study by the polymeric biotin-free technique...
March 29, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29570945/diagnostic-and-prognostic-value-of-serum-cripto-1-in-patients-with-non-small-cell-lung-cancer
#3
Chun Hua Xu, Chuan Zhen Chi, Qian Zhang, Yu Chao Wang, Wei Wang, Qi Yuan, Ping Zhan, Xiu Wei Zhang, Yong Lin
INTRODUCTION: Cripto-1 (CR-1) is a member of the epidermal growth factor (EGF)-CFC protein family, which is involved in tumor pathogenesis. OBJECTIVES: This study aimed to explore the diagnostic and prognostic value of serum CR-1 level in patients with non-small cell lung cancer (NSCLC). METHOD: Serum specimens from 312 NSCLC patients and 120 healthy controls were collected. Serum CR-1 level was measured using enzyme-linked immunosorbent assay (ELISA)...
March 23, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29506220/identification-of-trophectoderm-derived-cripto-as-an-essential-mediator-of-embryo-implantation
#4
Eran Gershon, Ron Hadas, Michal Elbaz, Evan Booker, Moran Muchnik, Alona Kleinjan, Sharon Karasenti, Olga Genin, Yuval Cinnamon, Peter C Gray
Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects including proliferation, migration, survival, EMT and angiogenesis to regulate embryogenesis, tissue homeostasis and tumorigenesis. Those cell behaviors are also associated with implantation of the embryo into the uterine wall and this led us to investigate the role of embryo-derived Cripto in embryo attachment and implantation. We show here that Cripto and its signaling mediator GRP78 are uniquely localized to embryo implantation sites...
February 28, 2018: Endocrinology
https://www.readbyqxmd.com/read/29445127/cripto-1-contributes-to-stemness-in-hepatocellular-carcinoma-by-stabilizing-dishevelled-3-and-activating-wnt-%C3%AE-catenin-pathway
#5
Regina Cheuk-Lam Lo, Carmen Oi-Ning Leung, Kristy Kwan-Shuen Chan, Daniel Wai-Hung Ho, Chun-Ming Wong, Terence Kin-Wah Lee, Irene Oi-Lin Ng
Identification and characterization of functional molecular targets conferring stemness properties in hepatocellular carcinoma (HCC) offers crucial insights to overcome the major hurdles of tumor recurrence, metastasis and chemoresistance in clinical management. In the current study, we investigated the significance of Cripto-1 in contributing to HCC stemness. Cripto-1 was upregulated in the sorafenib-resistant clones derived from HCC cell lines and patient-derived xenograft that we previously developed, suggesting an association between Cripto-1 and stemness...
February 14, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29413049/high-cripto-1-and-low-mir-205-expression-levels-as-prognostic-markers-in-early-stage-non-small-cell-lung-cancer
#6
Kang-Seo Park, Yong Wha Moon, Mark Raffeld, Dae Ho Lee, Yisong Wang, Giuseppe Giaccone
OBJECTIVES: Cripto-1 (CR-1) plays a critical role in the activation of SMAD, SRC, and epithelial-to-mesenchymal transition (EMT) pathways and has been shown to be prognostic in several cancer types. In addition, we showed that CR-1 renders EGFR-mutated NSCLC cells resistant to EGFR-TKI through the activation of SRC and EMT via miR-205 downregulation. This study aimed to investigate the correlation between expression of CR-1 and miR-205 and prognosis of NSCLC patients with or without EGFR mutations...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29396254/variation-in-primary-and-culture-expanded-cells-derived-from-connective-tissue-progenitors-in-human-bone-marrow-space-bone-trabecular-surface-and-adipose-tissue
#7
Maha A Qadan, Nicolas S Piuzzi, Cynthia Boehm, Wesley Bova, Malcolm Moos, Ronald J Midura, Vincent C Hascall, Christopher Malcuit, George F Muschler
BACKGROUND AIMS: Connective tissue progenitors (CTPs) embody the heterogeneous stem and progenitor cell populations present in native tissue. CTPs are essential to the formation and remodeling of connective tissue and represent key targets for tissue-engineering and cell-based therapies. To better understand and characterize CTPs, we aimed to compare the (i) concentration and prevalence, (ii) early in vitro biological behavior and (iii) expression of surface-markers and transcription factors among cells derived from marrow space (MS), trabecular surface (TS), and adipose tissues (AT)...
March 2018: Cytotherapy
https://www.readbyqxmd.com/read/29358554/knockdown-of-cripto-1-inhibits-the-proliferation-migration-invasion-and-angiogenesis-in-prostate-carcinoma-cells
#8
Ding Wu, Zhan Shi, Hao Xu, Renfu Chen, Song Xue, Xiaoqing Sun
Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto-1/FRL1/Cryptic gene family that plays a key role in the various malignant cancers. However, the role of CR-1 in prostate carcinoma (PCa) remains limited. The expression of CR-1 was down-regulated by small interfering RNA (siRNA). Western blot measured the expression levels of CR-1 and some related proteins. We performed Cell Counting Kit-8, 5-ethynyl-2-deoxyuridine (EdU) incorporation assay and flow cytometry to detect the cellular proliferation and cycle...
September 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29232368/ascorbic-acid-promotes-cardiomyogenesis-through-smad1-signaling-in-differentiating-mouse-embryonic-stem-cells
#9
Maria Grazia Perino, Satoshi Yamanaka, Daniel R Riordon, Yelena Tarasova, Kenneth R Boheler
Numerous groups have documented that Ascorbic Acid (AA) promotes cardiomyocyte differentiation from both mouse and human ESCs and iPSCs. AA is now considered indispensable for the routine production of hPSC-cardiomyocytes (CMs) using defined media; however, the mechanisms involved with the inductive process are poorly understood. Using a genetically modified mouse embryonic stem cell (mESC) line containing a dsRED transgene driven by the cardiac-restricted portion of the ncx1 promoter, we show that AA promoted differentiation of mESCs to CMs in a dose- and time-dependent manner...
2017: PloS One
https://www.readbyqxmd.com/read/29226519/cripto-stabilizes-grp78-on-the-cell-membrane
#10
Valentina L Kouznetsova, Hannah Hu, Knut Teigen, Maurizio Zanetti, Igor F Tsigelny
The ER resident chaperone molecule GRP78 has been shown to translocate to the cell surface where it associates with Cripto and signals cell growth, playing a still partially understood role in tumorigenesis. Consequently, a better understanding of GRP78 topology and structure at the surface of cancer cells represents an important step in the development of a new class of therapeutics. Here, we used a set of programs for creation of a complex containing GRP78 and Cripto proteins. We elucidated possible interactions of GRP78, Cripto, and their complex with the membrane...
March 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29113739/structural-insights-into-the-interaction-of-a-monoclonal-antibody-and-nodal-peptides-by-std-nmr-spectroscopy
#11
Luisa Calvanese, Annalia Focà, Annamaria Sandomenico, Giuseppina Focà, Andrea Caporale, Nunzianna Doti, Emanuela Iaccarino, Antonio Leonardi, Gabriella D'Auria, Menotti Ruvo, Lucia Falcigno
Nodal is a growth factor expressed during early embryonic development, but reactivated in several advanced-stage cancers. Targeting of Nodal signaling, which occurs via the binding to Cripto-1 co-receptor, results in inhibition of cell aggressiveness and reduced tumor growth. The Nodal binding region to Cripto-1 was identified and targeted with a high affinity monoclonal antibody (3D1). By STD-NMR technique, we investigated the interaction of Nodal fragments with 3D1 with the aim to elucidate at atomic level the interaction surface...
December 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29108289/clinical-significance-of-cripto-1-expression-in-lung-adenocarcinoma
#12
Hua Zhang, Bin Zhang, Liuwei Gao, Lianmin Zhang, Kaikai Zhu, Runfen Cheng, Changli Wang
Cripto-1 can promote tumourigenesis and may be a potential prognostic biomarker in several malignancies, yet little is known about this protein in lung adenocarcinoma (LAC). The aim of this study was to evaluate the prognostic value of cripto-1 expression in a cohort of patients with LAC. Tumours from 290 patients with pathologically confirmed LAC were used for an immunohistochemical analysis of cripto-1 expression. The correlation between cripto-1 expression and the clinicopathological parameters of patients, EGFR-TKI sensitivity was analysed...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28835002/cripto-enhances-proliferation-and-survival-of-mesenchymal-stem-cells-by-up-regulating-jak2-stat3-pathway-in-a-grp78-dependent-manner
#13
SeungPil Yun, Chul Won Yun, Jun Hee Lee, SangMin Kim, Sang Hun Lee
Cripto is a small glycosylphosphatidylinositol-anchored signaling protein that can detach from the anchored membrane and stimulate proliferation, migration, differentiation, vascularization, and angiogenesis. In the present study, we demonstrated that Cripto positively affected proliferation and survival of mesenchymal stem cells (MSCs) without affecting multipotency. Cripto also increased expression of phosphorylated janus kinase 2 (p-JAK2), phosphorylated signal transducer and activator of transcription 3 (p-STAT3), 78 kDa glucose-regulated protein (GRP78), c-Myc, and cyclin D1...
August 25, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28468864/nodal-signaling-as-a-developmental-therapeutics-target-in-oncology
#14
REVIEW
Aparna Kalyan, Benedito A Carneiro, Sunandana Chandra, Jason Kaplan, Young Kwang Chae, Maria Matsangou, Mary J C Hendrix, Francis Giles
The tumor microenvironment is a vital feature of oncogenesis and tumor progression. There are several parallels between cancer cells and early developmental stem cells, including their plasticity and signaling mechanisms. In early fetal development, Nodal is expressed for endodermal and mesodermal differentiation. This expression has been shown reemerge in the setting of epithelial cancers, such as breast and melanoma. High Nodal expression correlates to an aggressive tumor grade in these malignancies. Nodal signal begins with its interaction with its coreceptor, Cripto-1, leading to activation of Smad2/Smad3 and ultimately downstream transcription and translation...
May 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28468043/-prognostic-significance-of-cripto-1-in-cervical-squamous-carcinoma
#15
Q Q Xu, C C Ren, L Yang, Z Y Ban, L Liu, J H Lu, Y X Yu
No abstract text is available yet for this article.
May 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28431580/cripto-1-acts-as-a-functional-marker-of-cancer-stem-like-cells-and-predicts-prognosis-of-the-patients-in-esophageal-squamous-cell-carcinoma
#16
Qiang Liu, Xiang Cui, Xi Yu, Bai-Shi-Jiao Bian, Feng Qian, Xu-Gang Hu, Cheng-Dong Ji, Lang Yang, Yong Ren, Wei Cui, Xia Zhang, Peng Zhang, Ji Ming Wang, You-Hong Cui, Xiu-Wu Bian
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is highly malignant with highly invasive and metastatic capabilities and poor prognosis. It is believed that the ESCC cancer stem-like cells (ECSLCs) are critical for tumorigenicity, invasion and metastasis of ESCC. However, the properties of ECSLCs vary with different markers used in isolation, so that new and more effective markers of ECSLCs need to be identified. This study aimed to estimate the potentiality of Cripto-1 (CR-1) as an ECSLC surface marker and investigate the clinical significance of CR-1 expression in ESCC...
April 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28427175/clinical-significance-of-cripto-1-expression-in-lung-adenocarcinoma
#17
Hua Zhang, Bin Zhang, Liuwei Gao, Lianmin Zhang, Kaikai Zhu, Runfen Cheng, Changli Wang
Cripto-1 can promote tumourigenesis and may be a potential prognostic biomarker in several malignancies, yet little is known about this protein in lung adenocarcinoma (LAC). The aim of this study was to evaluate the prognostic value of cripto-1 expression in a cohort of patients with LAC. Tumours from 290 patients with pathologically confirmed LAC were used for an immunohistochemical analysis of cripto-1 expression. The correlation between cripto-1 expression and the clinicopathological parameters of patients, EGFR-TKI sensitivity was analysed...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28394345/cripto-and-its-signaling-partner-grp78-drive-the-metastatic-phenotype-in-human-osteotropic-prostate-cancer
#18
E Zoni, L Chen, S Karkampouna, Z Granchi, E I Verhoef, F La Manna, J Kelber, R C M Pelger, M D Henry, E Snaar-Jagalska, G J L H van Leenders, L Beimers, P Kloen, P C Gray, G van der Pluijm, M Kruithof-de Julio
CRIPTO (CR-1, TDGF1) is a cell surface/secreted oncoprotein actively involved in development and cancer. Here, we report that high expression of CRIPTO correlates with poor survival in stratified risk groups of prostate cancer (PCa) patients. CRIPTO and its signaling partner glucose-regulated protein 78 (GRP78) are highly expressed in PCa metastases and display higher levels in the metastatic ALDH(high) sub-population of PC-3M-Pro4Luc2 PCa cells compared with non-metastatic ALDH(low). Coculture of the osteotropic PC-3M-Pro4Luc2 PCa cells with differentiated primary human osteoblasts induced CRIPTO and GRP78 expression in cancer cells and increases the size of the ALDH(high) sub-population...
August 17, 2017: Oncogene
https://www.readbyqxmd.com/read/28367468/biological-and-clinicopathological-significance-of-cripto-1-expression-in-the-progression-of-human-escc
#19
Reihaneh Alsadat Mahmoudian, Mohammad Reza Abbaszadegan, Mohammad Mahdi Forghanifard, Meysam Moghbeli, Faezeh Moghbeli, Jamshidkhan Chamani, Mehran Gholamin
BACKGROUND: Human Cripto-1, a member of the EGF-CFC family, is involved in embryonic development, embryonic stem cell maintenance, and tumor progression. It also participates in multiple cell signaling pathways including Wnt, Notch, and TGF-β. Remarkably, it is expressed in cancer stem cell (CSC) compartments, boosting tumor cell migration, invasion, and angiogenesis. Although Cripto-1 is overexpressed in a variety of human malignant tumors, its expression in esophageal squamous cell carcinoma (ESCC) remains unclear...
April 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28359056/the-construction-and-identification-of-induced-pluripotent-stem-cells-derived-from-acute-myelogenous-leukemia-cells
#20
Liang-Fang Zhu, Qiu-Ru Chen, Shao-Zhen Chen, Ling-Yan Wang, Xiao-Feng Luo, Jin-Hua Ren, Xiao-Hong Yuan, Xue-Qiong Wu, Yan-Ling Zeng, Min Xiao, Yong-Quan Chen, Ying-Yu Chen, Min-Hui Lin, Zheng-Jun Wu, Zhi-Zhe Chen, Jian-Da Hu, Ting Yang
OBJECTIVE: The present study aimed to establish an induced pluripotent stem cell (iPSC) line from acute myelogenous leukemia (AML) cells in vitro and identify their biological characteristics. METHODS: Cells from the AML-infiltrated skin from an M6 patient were infected with a lentivirus carrying OCT4, SOX2, KLF4 and C-MYC to induce iPSCs. The characteristics of the iPSCs were confirmed by alkaline phosphatase (ALP) staining. The proliferation ability of iPSCs was detected with a CCK-8 assay...
2017: Cellular Physiology and Biochemistry
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