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https://www.readbyqxmd.com/read/29139477/a-dietary-flavone-confers-communicable-protection-against-colitis-through-nlrp6-signaling-independently-of-inflammasome-activation
#1
K Radulovic, S Normand, A Rehman, A Delanoye-Crespin, J Chatagnon, M Delacre, N Waldschmitt, L F Poulin, J Iovanna, B Ryffel, P Rosenstiel, M Chamaillard
Flavones represent a class of polyphenols that are found in many plant-derived food sources. Herein, we provide evidence that the anti-inflammatory and antiproliferative effect of the flavone apigenin relies on the regulation of the gut microbiota by the NOD-like receptor family pyrin domain containing 6 (Nlrp6). When challenged by dextran sulfate sodium (DSS) in drinking water, mice were protected against colitis upon cohousing with apigenin-treated animals. In contrast, the protective effect was lost in the absence of Nlrp6...
November 15, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29133466/shine-dalgarno-sequences-play-an-essential-role-in-the-translation-of-plastid-mrnas-in-tobacco
#2
Lars B Scharff, Miriam Ehrnthaler, Marcin Janowski, Liam H Childs, Claudia Hasse, Jürgen Gremmels, Stephanie Ruf, Reimo Zoschke, Ralph Bock
In prokaryotic systems, the translation initiation of many, though not all, mRNAs depends on interaction between a sequence element upstream of the start codon (the Shine-Dalgarno sequence, SD) and a complementary sequence in the 3' end of the 16S ribosomal RNA (anti-Shine-Dalgarno sequence, aSD). Although many chloroplast mRNAs harbor putative SDs in their 5' untranslated regions and the aSD displays strong conservation, the functional relevance of SD-aSD interactions in plastid translation is unclear. Here, by generating transplastomic tobacco (Nicotiana tabacum) mutants with point mutations in the aSD coupled with genome-wide analysis of translation by ribosome profiling, we provide a global picture of SD-dependent translation in plastids...
November 13, 2017: Plant Cell
https://www.readbyqxmd.com/read/29121798/angelica-sinensis-exerts-angiogenic-and-anti-apoptotic-effects-against-cerebral-ischemia-reperfusion-injury-by-activating-p38mapk-hif-1-formula-see-text-vegf-a-signaling-in-rats
#3
Chin-Yi Cheng, Tin-Yun Ho, Chien-Yun Hsiang, Nou-Ying Tang, Ching-Liang Hsieh, Shung-Te Kao, Yu-Chen Lee
This study evaluated the effects of Angelica sinensis extract [Dang Gui (DG)] administered before 60[Formula: see text]min of middle cerebral artery occlusion followed by 3[Formula: see text]d of reperfusion and investigated the involvement of mitogen-activated protein kinase (MAPK)/hypoxia-inducible factor (HIF)-1[Formula: see text] signaling in the cortical ischemic penumbra. DG was intraperitoneally administered at a dose of 0.25[Formula: see text]g/kg (DG-0.25g), 0.5[Formula: see text]g/kg (DG-0.5g), or 1[Formula: see text]g/kg (DG-1g) 30[Formula: see text]min before the onset of cerebral ischemia...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29113237/microrna-10a-suppresses-breast-cancer-progression-via-pi3k-akt-mtor-pathway
#4
Kongliang Ke, Tingting Lou
Previous studies have demonstrated that microRNA-10a (miR-10a) regulates various opposing biological functions in breast cancer. The aim of the present study was to investigate the exact functions of miR-10a in the pathogenesis of breast cancer. miR-10a expression was initially detected in two human breast cancer cell lines, MCF-7 and MDA-MB-231 and a normal human mammary epithelial cell line MCF-10A. The proliferation, migration and apoptosis of breast cancer cells were analyzed using MTT assays, Transwell assays and flow cytometry, respectively, following transfection of MCF-7 and MDA-MB-231 cells with an miR-10a mimic or anti-miR-10a...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110153/protection-by-mtor-inhibition-on-zymosan-induced-systemic-inflammatory-response-and-oxidative-nitrosative-stress-contribution-of-mtor-mek1-erk1-2-ikk%C3%AE-i%C3%AE%C2%BAb-%C3%AE-nf-%C3%AE%C2%BAb-signalling-pathway
#5
Seyhan Sahan-Firat, Meryem Temiz-Resitoglu, Demet Sinem Guden, Sefika Pinar Kucukkavruk, Bahar Tunctan, Ayse Nihal Sari, Zumrut Kocak, Kafait U Malik
Mammalian target of rapamycin (mTOR), a serine/threonine kinase regulate variety of cellular functions including cell growth, differentiation, cell survival, metabolism, and stress response, is now appreciated to be a central regulator of immune responses. Because mTOR inhibitors enhanced the anti-inflammatory activities of regulatory T cells and decreased the production of proinflammatory cytokines by macrophages, mTOR has been a pharmacological target for inflammatory diseases. In this study, we examined the role of mTOR in the production of proinflammatory and vasodilator mediators in zymosan-induced non-septic shock model in rats...
November 6, 2017: Inflammation
https://www.readbyqxmd.com/read/29107485/the-cryo-em-structure-of-a-novel-40s-kinetoplastid-specific-ribosomal-protein
#6
Jailson Brito Querido, Eder Mancera-Martínez, Quentin Vicens, Anthony Bochler, Johana Chicher, Angelita Simonetti, Yaser Hashem
Kinetoplastids are potentially lethal protozoan pathogens affecting more than 20 million people worldwide. There is a critical need for more specific targets for the development of safer anti-kinetoplastid therapeutic molecules that can replace the scarce and highly cytotoxic current drugs. The kinetoplastid ribosome represents a potential therapeutic target due to its relative structural divergence when compared with its human counterpart. However, several kinetoplastid-specific ribosomal features remain uncharacterized...
October 13, 2017: Structure
https://www.readbyqxmd.com/read/29096754/overview-of-ribosomal-and-non-ribosomal-antimicrobial-peptides-produced-by-gram-positive-bacteria
#7
M Tajbakhsh, A Karimi, F Fallah, M M Akhavan
The increasing incidence of antimicrobial resistance bacterial infection and decreasing effectiveness of conventional antibiotics to treatment have caused serious problems worldwide. The demand for new generationantibiotics to combat microbial pathogens is imperative. Cationic antimicrobial peptides (AMPs) with different sources from prokaryotic to complex eukaryotic organisms, with variable length, amino acid composition and secondary structure, have been consideredduring the past decades.  The advantages of large number of AMPs are related to broad spectrum and morphogenetic activities, low resistance rate among microorganismswithout side effect on human cells, rapid killing of bacteria via membrane damage and intracellular targets,and their critical roles in anti-inflammatory...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29093254/aberration-in-translation-initiation-and-associated-diseases-role-of-the-eukaryotic-translation-initiation-factor-3a
#8
Tao Zhu, Yuanfeng Gao, Ling Li, Leiyun Wang, Jiye Yin, Honghao Zhou, Wei Zhang, Zhaoqian Liu
Translation control in eukaryotes contributes significantly to gene expression regulation during cellular processes, which enables rapid changes of specific proteins to maintain cellular homeostasis. Eukaryotic translation is a multiple-step process that comprised of four phases: initiation, elongation, termination and ribosome recycling. The initiation phase is rate-limiting and orchestrated by a set of eukaryotic translation initiation factors (eIFs). Defects in translation initiation can result in a series of diseases...
October 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29091188/inducibility-of-tn916-conjugative-transfer-in-enterococcus-faecalis-by-subinhibitory-concentrations-of-ribosome-targeting-antibiotics
#9
Hélène Scornec, Xavier Bellanger, Hélène Guilloteau, Guillaume Groshenry, Christophe Merlin
Background: Some antibiotics induce the dissemination of their own resistance genes by interfering with the regulation of specific mobile genetic elements. In Tn916, subinhibitory concentrations of tetracycline activate the transfer of the element through an anti-attenuation mechanism that relies on the Tet(M) resistance protein, itself encoded by the element. Objectives: This work explores the effects of a broad range of antibiotics on the transfer of Tn916 and for which the element does not provide any selective advantage...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29053248/in-vitro-evolution-of-unmodified-16s-rrna-for-simple-ribosome-reconstitution
#10
Yoshiki Murase, Hiroki Nakanishi, Gakushi Tsuji, Takeshi Sunami, Norikazu Ichihashi
One of the largest challenges in the synthesis of artificial cell that can reproduce is in vitro assembly of ribosomes from in vitro synthesized rRNAs and proteins. In this study, to circumvent the chemical modification of 16S rRNA for reconstitution of fully active 30S subunit, we performed artificial evolution of 16S rRNA, which forms the functional 30S subunit without chemical modifications. We first established an in vitro selection scheme by combining the integrated synthesis, assembly, and translation (iSAT) system with the liposome sorting technique...
October 20, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29048653/ribosomal-protein-s3-regulates-xiap-expression-independently-of-the-nf-%C3%AE%C2%BAb-pathway-in-breast-cancer-cells
#11
Hisako Ono, Yosuke Iizumi, Wakana Goi, Yoshihiro Sowa, Tetsuya Taguchi, Toshiyuki Sakai
The X-linked inhibitor of apoptosis (XIAP) confers the resistance of various types of cancer to standard chemotherapeutic agents such as anthracycline and taxane. In breast cancer, XIAP is known to be overexpressed. However, the mechanisms underlying the overexpression of XIAP remain currently unclear. In order to elucidate the mechanisms responsible for the overexpression of the XIAP protein in breast cancer, we attempted to clarify the mechanisms by which the natural compound curcumin downregulates XIAP in breast cancer cells...
September 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29038898/molecular-and-immunological-characterisation-of-tropomyosin-from-anisakis-pegreffii
#12
Abdouslam Asnoussi, Ibukun E Aibinu, Robin B Gasser, Andreas L Lopata, Peter M Smooker
Tropomyosin (TM) is a major allergen in shellfish, known to cross-react with mite, cockroach and/or some roundworm (nematode) TM. In this study, we aimed to express and purify TM from the parasitic nematode Anisakis pegreffii and also to characterise its cross-reactivity with TM from shellfish. A. pegreffii was isolated from the flathead tiger fish (Neoplatycephalus richardsoni) and characterised using single-strand conformation polymorphism (SSCP)-based sequencing of the first and second internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA...
October 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28978152/mitochondrial-markers-predict-recurrence-metastasis-and-tamoxifen-resistance-in-breast-cancer-patients-early-detection-of-treatment-failure-with-companion-diagnostics
#13
Federica Sotgia, Marco Fiorillo, Michael P Lisanti
Here, we used a data-mining and informatics approach to discover new biomarkers of resistance to hormonal therapy in breast cancer. More specifically, we investigated whether nuclear-encoded genes associated with mitochondrial biogenesis can be used to predict tumor recurrence, distant metastasis and treatment failure in high-risk breast cancer patients. Overall, this strategy allowed us to directly provide in silico validation of the prognostic value of these mitochondrial components in large and clinically relevant patient populations, with >15 years of follow-up data...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978045/mitoriboscins-mitochondrial-based-therapeutics-targeting-cancer-stem-cells-cscs-bacteria-and-pathogenic-yeast
#14
Bela Ozsvari, Marco Fiorillo, Gloria Bonuccelli, Anna Rita Cappello, Luca Frattaruolo, Federica Sotgia, Rachel Trowbridge, Richard Foster, Michael P Lisanti
The "endo-symbiotic theory of mitochondrial evolution" states that mitochondrial organelles evolved from engulfed aerobic bacteria, after millions of years of symbiosis and adaptation. Here, we have exploited this premise to design new antibiotics and novel anti-cancer therapies, using a convergent approach. First, virtual high-throughput screening (vHTS) and computational chemistry were used to identify novel compounds binding to the 3D structure of the mammalian mitochondrial ribosome. The resulting library of ∼880 compounds was then subjected to phenotypic drug screening on human cancer cells, to identify which compounds functionally induce ATP-depletion, which is characteristic of mitochondrial inhibition...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978020/mitochondrial-biomarkers-predict-tumor-progression-and-poor-overall-survival-in-gastric-cancers-companion-diagnostics-for-personalized-medicine
#15
Federica Sotgia, Michael P Lisanti
Here, we employed a bioinformatics approach to identify novel molecular determinants to predict tumor progression and overall survival in gastric cancer patients. In particular, we directly assessed whether nuclear-derived mRNA species encoding proteins involved in mitochondrial protein translation and OXPHOS are able to successfully predict clinical outcome in gastric cancer. As such, using in silico validation, we have now established the prognostic value of these mitochondrial biomarkers, in a defined population of gastric cancer patients...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978006/mitochondrial-mrna-transcripts-predict-overall-survival-tumor-recurrence-and-progression-in-serous-ovarian-cancer-companion-diagnostics-for-cancer-therapy
#16
Federica Sotgia, Michael P Lisanti
Here, we performed a systematic analysis to discover new biomarkers of overall survival and tumor progression in ovarian cancer patients. More specifically, we determined whether nuclear-encoded mitochondrial genes related to mitochondrial biogenesis and function are effective in predicting clinical outcome in ovarian cancer. As a consequence, we are able to provide in silico validation of the prognostic value of these mitochondrial markers, in a well-defined population of ovarian cancer patients. Towards this end, we used a group of N=111 ovarian cancer patients (serous type; stage III), with optimal de-bulking...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969051/sp110-enhances-macrophage-resistance-to-mycobacterium-tuberculosis-via-inducing-endoplasmic-reticulum-stress-and-inhibiting-anti-apoptotic-factors
#17
Yongyan Wu, Zekun Guo, Fayang Liu, Kezhen Yao, Mingqing Gao, Yan Luo, Yong Zhang
Tuberculosis remains a leading health problem worldwide and still accounts for about 1.3 million deaths annually. Expression of the mouse Sp110 nuclear body protein (Sp110) upregulates the apoptotic pathway, which plays an essential role in enhancing host immunity to Mycobacterium tuberculosis (Mtb). However, the mechanism of this upregulation is unclear. Here, we have identified 253 proteins in mouse macrophages that interact with Sp110, of which 251 proteins were previously uncharacterized. The results showed that Sp110 interacts with heat shock protein 5 (Hspa5) to activate endoplasmic reticulum (ER) stress-induced apoptosis, and that this is essential for Sp110 enhanced macrophage resistance to Mtb...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968860/retracted-anti-ribosomal-phosphoprotein-autoantibodies-penetrate-to-neuronal-cells-via-neuronal-growth-associated-protein-affecting-neuronal-cells-in-vitro
#18
Shaye Kivity, Yehuda Shoenfeld, Maria-Teresa Arango, Dolores J Cahill, Sara Louise O'Kane, Margalit Zusev, Inna Slutsky, Michal Harel-Meir, Joab Chapman, Torsten Matthias, Miri Blank
No abstract text is available yet for this article.
August 10, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968491/a-genomics-based-approach-identifies-a-thioviridamide-like-compound-with-selective-anticancer-activity
#19
Luca Frattaruolo, Rodney Lacret, Anna Rita Cappello, Andrew W Truman
Thioviridamide is a structurally novel ribosomally synthesized and post-translational modified peptide (RiPP) produced by Streptomyces olivoviridis NA005001. It is characterized by a structure that features a series of thioamide groups and possesses potent antiproliferative activity in cancer cell lines. Its unusual structure allied to its promise as an anticancer compound led us to investigate the diversity of thioviridamide-like pathways across sequenced bacterial genomes. We have isolated and characterized three diverse members of this family of natural products...
November 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28963859/unfolded-protein-exhibits-antiassociation-activity-towards-the-50s-subunit-facilitating-70s-ribosome-dissociation
#20
Bani K Pathak, Senjuti Banerjee, Surojit Mondal, B Chakraborty, J Sengupta, Chandana Barat
The ability of the ribosome to assist in folding of proteins both in vitro and in vivo is well documented. The interaction of the unfolded protein with the peptidyltransferase center (PTC) of the bacterial large ribosomal subunit is followed by release of the protein in a folding competent state and rapid dissociation of ribosome into its subunits. Our studies demonstrate that the 50S subunit associated anti-association ability of unfolded protein might contribute significantly to its ability to mediate energy independent and stable dissociation of ribosome into its subunits...
September 30, 2017: FEBS Journal
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