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https://www.readbyqxmd.com/read/29778844/identification-of-micrornas-with-heat-stress-responsive-and-immune-properties-in-marsupenaeus-japonicus-based-on-next-generation-sequencing-and-bioinformatics-analysis-essential-regulators-in-the-heat-stress-host-interactions
#1
Jinbin Zheng, Jiawen Cao, Yong Mao, Yongquan Su, Jun Wang
Summer mortality syndrome is one of the most serious issue for Marsupenaeus japonicus aquaculture in China. Since it causes massive economic loss and threatens sustainability of M. japonicus aquaculture industry, thus, there is an urgent desire to reveal the heat stress-host interactions mechanisms that lead to mass mortalities of M. japonicus in hot summer months. MicroRNAs (miRNAs) are small noncoding RNAs that involved in regulation of diverse biological processes, including stress and immune response, and might serve as potential regulators in the heat stress-host interactions...
May 17, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29772587/anti-inflammatory-effects-of-cardamonin-in-ovarian-cancer-cells-are-mediated-via-mtor-suppression
#2
Huajiao Chen, Daohua Shi, Peiguang Niu, Yanting Zhu, Jintuo Zhou
Cardamonin exhibits a variety of pharmacological activities including anti-inflammatory and antitumor, which are correlated with the inhibition of nuclear factor-kappaB and the mammalian target of rapamycin, respectively. However, whether the anti-inflammatory effects of cardamonin are mediated by the mammalian target of rapamycin remains unknown. In this study, ovarian cancer SKOV3 cells were cultured with lipopolysaccharide to induce inflammation, and the inhibitory effects and underlying molecular mechanisms of cardamonin were investigated using specific inhibitors of the mammalian target of rapamycin and the nuclear factor-kappaB pathway (rapamycin and pyrrolidine dithiocarbamate, respectively)...
May 17, 2018: Planta Medica
https://www.readbyqxmd.com/read/29761175/anti-tumoral-effects-of-exercise-on-hepatocellular-carcinoma-growth
#3
Uttara Saran, Maria Guarino, Sarai Rodríguez, Cedric Simillion, Matteo Montani, Michelangelo Foti, Bostjan Humar, Marie V St-Pierre, Jean-François Dufour
Regular physical exercise has many beneficial effects, including antitumor properties, and is associated with a reduced risk of developing hepatocellular carcinoma (HCC). Less is known about the impact of exercise on HCC growth and progression. Here, we investigated the effects of exercise on HCC progression and assessed whether any beneficial effects would be evident under sorafenib treatment and could be mimicked by metformin. American Cancer Institute rats with orthotopic syngeneic HCC derived from Morris Hepatoma-3924A cells were randomly assigned to exercise (Exe) and sedentary groups, or sorafenib±Exe groups or sorafenib±metformin groups...
May 2018: Hepatology communications
https://www.readbyqxmd.com/read/29737965/identification-and-characterization-of-a-novel-single-chain-variable-fragment-scfv-antibody-against-neisseria-meningitidis-factor-h-binding-protein-fhbp
#4
Fatemeh Yarian, Bahram Kazemi, Mojgan Bandehpour
PURPOSE: Neisseria meningitidis is the leading global cause of meningitis and sepsis. Detection, followed by identification, of bacterial pathogens is important in medicine and public health. In the present study, we used the ribosome display technique to select single-chain variable fragments (scFv) that are specific to the surface-exposed fHbp antigen of N. meningitidis. METHODOLOGY: The recombinant fHbp protein was used as the antigen for the immunization of BALB/c mice...
May 8, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29734756/translation-control-by-p53
#5
Justina Kasteri, Dibash Das, Xuelin Zhong, Leah Persaud, Ashleigh Francis, Hilal Muharam, Moira Sauane
The translation of mRNAs plays a critical role in the regulation of gene expression and therefore, in the regulation of cell proliferation, differentiation and apoptosis. Unrestricted initiation of translation causes malignant transformation and plays a key role in the maintenance and progression of cancers. Translation initiation is regulated by the ternary complex and the eukaryotic initiation factor 4F (eIF4F) complex. The p53 tumor suppressor protein is the most well studied mammalian transcription factor that mediates a variety of anti-proliferative processes...
May 5, 2018: Cancers
https://www.readbyqxmd.com/read/29734689/the-interaction-of-the-metallo-glycopeptide-anti-tumour-drug-bleomycin-with-dna
#6
REVIEW
Vincent Murray, Jon K Chen, Long H Chung
The cancer chemotherapeutic drug, bleomycin, is clinically used to treat several neoplasms including testicular and ovarian cancers. Bleomycin is a metallo-glycopeptide antibiotic that requires a transition metal ion, usually Fe(II), for activity. In this review, the properties of bleomycin are examined, especially the interaction of bleomycin with DNA. A Fe(II)-bleomycin complex is capable of DNA cleavage and this process is thought to be the major determinant for the cytotoxicity of bleomycin. The DNA sequence specificity of bleomycin cleavage is found to at 5′-GT* and 5′-GC* dinucleotides (where * indicates the cleaved nucleotide)...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29731854/cantharidin-suppresses-cell-growth-and-migration-and-activates-autophagy-in-human-non-small-cell-lung-cancer-cells
#7
Yan-Peng Liu, Ling Li, Liang Xu, E-Nuo Dai, Wei-Da Chen
Cantharidin (CTD), a component of Mylabris (blister beetle), is a traditional Chinese medicine that exerts an anticancer effect in multiple types of cancer cells. The aim of the present study was to investigate whether CTD exhibited anti-metastatic and inhibitory cell proliferation effects against human non-small cell lung cancer (NSCLC) A549 cells, and the possible underlying mechanism by which this occurs. The results of the present study demonstrated that CTD arrested proliferation, suppressed invasion and migration and induced apoptosis in A549 cells in vitro ...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29726280/modulatory-effect-of-three-probiotic-strains-on-infants-gut-microbial-composition-and-immunological-parameters-on-a-placebo-controlled-double-blind-randomised-study
#8
J De Andrés, S Manzano, C García, J M Rodríguez, I Espinosa-Martos, E Jiménez
The gut microbiota plays a crucial role in gastrointestinal health. Current use of probiotics is aimed at modulating the bacterial gut composition to alleviate specific diseases. The safety and tolerance of three probiotic strains (Bifidobacterium longum subsp. infantis R0033, Lactobacillus helveticus R0052 and Bifidobacterium bifidum R0071) has recently been described. The objective of the present study was to analyse the microbiological composition and immunological parameters of faecal samples obtained from healthy infants from 3 to 12 months of age after receiving either one of the three probiotic strains or placebo for 8 weeks...
May 4, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29719611/inhibition-of-ires-dependent-translation-of-caspase-2-by-hur-confers-chemotherapeutic-drug-resistance-in-colon-carcinoma-cells
#9
Amel Badawi, Abhiruchi Biyanee, Usman Nasrullah, Sofia Winslow, Tobias Schmid, Josef Pfeilschifter, Wolfgang Eberhardt
HuR plays an important role in tumor cell survival mainly through posttranscriptional upregulation of prominent anti-apoptotic genes. In addition, HuR can inhibit the translation of pro-apoptotic factors as we could previously report for caspase-2. Here, we investigated the mechanisms of caspase-2 suppression by HuR and its contribution to chemotherapeutic drug resistance of colon carcinoma cells. In accordance with the significant drug-induced increase in cytoplasmic HuR abundance, doxorubicin and paclitaxel increased the interaction of cytoplasmic HuR with the 5'untranslated region (5'UTR) of caspase-2 as shown by RNA pull down assay...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29701675/comparative-analysis-of-the-complete-chloroplast-genomes-of-four-aconitum-medicinal-species
#10
Jing Meng, Xuepei Li, Hongtao Li, Junbo Yang, Hong Wang, Jun He
Aconitum (Ranunculaceae) consists of approximately 400 species distributed in the temperate regions of the northern hemisphere. Many species are well-known herbs, mainly used for analgesia and anti-inflammatory purposes. This genus is well represented in China and has gained widespread attention for its toxicity and detoxification properties. In southwestern China, several Aconitum species, called ‘Dula’ in the Yi Nationality, were often used to control the poisonous effects of other Aconitum plants...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29699632/mulberry-anthocyanins-improves-thyroid-cancer-progression-mainly-by-inducing-apoptosis-and-autophagy-cell-death
#11
Hou-Long Long, Feng-Feng Zhang, Hong-Ling Wang, Wen-Shi Yang, Hai-Tao Hou, Jing-Kui Yu, Bin Liu
Dietary anthocyanin compounds have multiple biological effects, including antioxidant, anti-inflammatory, and anti-atherosclerotic characteristics. The present study evaluated the anti-tumor capacity of mulberry anthocyanins (MA) in thyroid cancer cells. Our data showed that MA suppressed SW1736 and HTh-7 cell proliferation in a time- and dose-dependent manner. Meanwhile, flow cytometry results indicated that MA significantly increased SW1736 and HTh-7 cell apoptosis. We additionally observed that SW1736 and HTh-7 cell autophagy was markedly enhanced after MA treatment...
May 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29695775/the-plant-hormone-abscisic-acid-regulates-the-growth-and-metabolism-of-endophytic-fungus-aspergillus-nidulans
#12
Gangming Xu, Suiqun Yang, Linghong Meng, Bin-Gui Wang
Plant hormones are well known chemical signals that regulate plant growth, development, and adaptation. However, after comparative transcriptome and metabolite analysis, we found that the plant hormone abscisic acid (ABA) also affect the growth and metabolism of endophytic fungus Aspergillus nidulans. There were 3148 up-regulated and 3160 down-regulated genes identified during 100 nM ABA induction. These differentially expressed genes (DEGs) were mainly involved in: RNA polymerase and basal transcription factors; ribosome biogenesis, protein processing, proteasome, and ubiquitin mediated proteolysis; nucleotide metabolism and tri-carboxylic acid (TCA) cycle; cell cycle and biosynthesis of secondary metabolites...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29695421/a-novel-marsupial-hepatitis-a-virus-corroborates-complex-evolutionary-patterns-shaping-the-genus-hepatovirus
#13
Ianei de Oliveira Carneiro, Anna-Lena Sander, Namá Silva, Andres Moreira-Soto, Andrea Normann, Bertram Flehmig, Alexander N Lukashev, Andreas Dotzauer, Nicolas Wieseke, Carlos Roberto Franke, Jan Felix Drexler
The discovery of nonprimate hepatoviruses illuminated the evolutionary origins of hepatitis A virus (HAV) in small mammals. Marsupials are ancient mammals that diverged during the Jurassic from other Eutheria. Viruses from marsupials may thus provide important insight into virus evolution. To investigate Hepatovirus macroevolutionary patterns, we sampled 112 opossums in northeastern Brazil. A novel marsupial HAV (MHAV) was detected in a Brazilian Common Opossum ( Didelphis aurita ) by nested RT-PCR. MHAV concentration in liver was high at 2...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29693372/biosynthesis-of-the-15-membered-ring-depsipeptide-neoantimycin
#14
Will Skyrud, Joyce Liu, Divya Thankachan, Maria Cabrera, Ryan F Seipke, Wenjun Zhang
Antimycins are a family of natural products possessing outstanding biological activities and unique structures, which have intrigued chemists for over a half century. Of particular interest are the ring-expanded antimycins that show promising anti-cancer potential and whose biosynthesis remains uncharacterized. Specifically, neoantimycin and its analogs have been shown to be effective regulators of the oncogenic proteins GRP78/BiP and K-Ras. The neoantimycin structural skeleton is built on a 15-membered tetralactone ring containing one methyl, one hydroxy, one benzyl and three alkylmoieties, as well as an amide linkage to a conserved 3-formamidosalicylic acid moiety...
April 25, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29685892/expansion-of-dub-functionality-by-alternative-isoforms-usp35-a-case-study
#15
Pawel Leznicki, Jayaprakash Natarajan, Gerd Bader, Walter Spevak, Andreas Schlattl, Syed Arif Abdul Rehman, Deepika Pathak, Simone Weidlich, Andreas Zoephel, Marie C Bordone, Nuno L Barbosa-Morais, Guido Boehmelt, Yogesh Kulathu
Protein ubiquitylation is a dynamic post-translational modification that can be reversed by deubiquitylating enzymes (DUBs). It is unclear how the small number of ∼100 DUBs present in mammalian cells regulates the thousands of different ubiquitylation events. Here we analysed annotated transcripts of human DUBs and find ∼300 ribosome-associated transcripts annotated as protein coding, which thus increase the total number of DUBs. Using USP35, a poorly studied DUB, as a case study we provide evidence that alternative isoforms contribute to the functional expansion of DUBs...
April 23, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29684330/novel-bioactive-peptides-from-pd-l1-2-a-type-1-ribosome-inactivating-protein-from-phytolacca-dioica-l-evaluation-of-their-antimicrobial-properties-and-anti-biofilm-activities
#16
Elio Pizzo, Katia Pane, Andrea Bosso, Nicola Landi, Sara Ragucci, Rosita Russo, Rosa Gaglione, Marcelo D T Torres, Cesar de la Fuente-Nunez, Angela Arciello, Alberto Di Donato, Eugenio Notomista, Antimo Di Maro
Antimicrobial peptides, also called Host Defence Peptides (HDPs), are effectors of innate immune response found in all living organisms. In a previous report, we have identified by chemical fragmentation, and characterized the first cryptic antimicrobial peptide in PD-L4, a type 1 ribosome-inactivating protein (RIP) from leaves of Phytolacca dioica L. We applied a recently developed bioinformatic approach to a further member of the differently expressed pool of type 1 RIPs from P. dioica (PD-L1/2), and identified two novel putative cryptic HDPs in its N-terminal domain...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29662647/characterization-of-increasing-stages-of-invasiveness-identifies-stromal-cancer-cell-crosstalk-in-rat-models-of-mesothelioma
#17
Joëlle S Nader, Jérôme Abadie, Sophie Deshayes, Alice Boissard, Stéphanie Blandin, Christophe Blanquart, Nicolas Boisgerault, Olivier Coqueret, Catherine Guette, Marc Grégoire, Daniel L Pouliquen
Sarcomatoid mesothelioma (SM) is a devastating cancer associated with one of the poorest outcome. Therefore, representative preclinical models reproducing different tumor microenvironments (TME) observed in patients would open up new prospects for the identification of markers and evaluation of innovative therapies. Histological analyses of four original models of rat SM revealed their increasing infiltrative and metastatic potential were associated with differences in Ki67 index, blood-vessel density, and T-lymphocyte and macrophage infiltration...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662633/tracking-cellular-and-molecular-changes-in-a-species-specific-manner-during-experimental-tumor-progression-in-vivo
#18
Emilie Indersie, Katarzyna B Hooks, Caroline Capdevielle, Monique Fabre, Nathalie Dugot-Senant, Angélique Desplat, Sébastien Lepreux, Aksam Merched, Christophe F Grosset, Martin Hagedorn
Hepatoblastoma (HBL) is a pediatric liver cancer with defined molecular alterations driving its progression. Here, we describe an animal model for HBL on the chick chorioallantoic membrane (CAM), which recapitulates relevant features of HBL in patients. Expression of classic tumor-associated proteins such as β-catenin, EpCAM and CK19 was maintained in acini-like organized tumors on CAM, as was synthesis of AFP, a tumor marker used for monitoring patient response. RNA sequencing revealed an unexpected molecular evolution of HBL cells on the CAM, with significant deregulation of more than 6,000 genes including more than half of all HOX genes...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661879/accelerating-early-anti-tuberculosis-drug-discovery-by-creating-mycobacterial-indicator-strains-that-predict-mode-of-action
#19
Maikel Boot, Susanna Commandeur, Amit K Subudhi, Meriem Bahira, Trever C Smith, Abdallah M Abdallah, Mae van Gemert, Joël Lelièvre, Lluís Ballell, Bree B Aldridge, Arnab Pain, Alexander Speer, Wilbert Bitter
Due to the rise of drug resistant forms of tuberculosis there is an urgent need for novel antibiotics to effectively combat these cases and shorten treatment regimens. Recently, drug screens using whole cell analyses have been shown to be successful. However, current high-throughput screens focus mostly on stricto sensu life-death screening that give little qualitative information. In doing so, promising compound scaffolds or non-optimized compounds that fail to reach inhibitory concentrations are missed. To accelerate early TB drug discovery, we performed RNA sequencing on Mycobacterium tuberculosis and Mycobacterium marinum to map the stress responses that follow upon exposure to sub-inhibitory concentrations of antibiotics with known targets: ciprofloxacin, ethambutol, isoniazid, streptomycin and rifampicin...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29657255/genome-wide-sirna-screening-in-mouse-bone-marrow-derived-macrophages-revealed-that-knockdown-of-ribosomal-proteins-suppresses-il-10-and-enhances-tnf-%C3%AE-production
#20
Yoshihiko Okamura, Naoyuki Makita, Yoshiyuki Hizukuri, Yasuhiro Hayashi
Macrophages play a central role in the immune response, and their diverse functions are attributed to the spectrum of their functional states. To elucidate molecules involved in modulating the balance between the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine TNF-α, we conducted genome-wide siRNA screening. First, we established an siRNA screening system using mouse bone marrow-derived macrophages, which are a suitable model for studying functional states of macrophages in vitro. In the primary screen and the subsequent reproducibility assay, 112 siRNA pools demonstrated enhancement of IL-10 production and 497 siRNA pools suppressed IL-10 production...
April 13, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
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