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Khaled Ezzedine, Maxine Whitton, Mariona Pinart
Clinical Question: Which interventions are associated with highest efficacy and fewest adverse events for treating vitiligo? Bottom Line: Combination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo. There was moderate evidence to support the association of UV-A and UV-B, when used in combination with psoralens, topical corticosteroids, vitamin D analogues, fluorouracil, azathioprine, and oral prednisolone with improved outcomes for vitiligo...
October 25, 2016: JAMA: the Journal of the American Medical Association
Vicente Rodríguez-González, Ruth B Domínguez-Espíndola, Sergio Casas-Flores, Olga A Patrón-Soberano, Roberto Camposeco Solis, Soo Wohn Lee
Antifungal silver nanocomposites inspired by titanate nanotubes (AgTNTs) were successfully evaluated for the effective inactivation of the phytopathogenic fungus Botrytis Cinerea within 20 minutes. One dimensional H2Ti3O7 nanotubes functionalized with silver nanoparticles (AgNPs) exhibit unique surface and antifungal properties for the photoinactivation of B. Cinerea. Nanostructured titanates were synthesized by the eco-friendly, practical, microwave-induced, hydrothermal method followed by a highly monodispersive AgNP UV-photodeposition...
October 26, 2016: ACS Applied Materials & Interfaces
Brandi L Baldock, James E Hutchison
DNA-functionalized gold nanoparticles have been increasingly applied as sensitive and selective analytical probes and biosensors. The DNA ligands bound to a nanoparticle dictate its reactivity, making it essential to know the type and number of DNA strands bound to the nanoparticle surface. Existing methods used to determine the number of DNA strands per gold nanoparticle (AuNP) require that the sequences be fluorophore labeled, which may affect the DNA surface coverage and reactivity of the nanoparticle, and/or require specialized equipment and other fluorophore-containing reagents...
October 26, 2016: Analytical Chemistry
Sergey N Konchenko, Svetlana V Klementieva, Nina P Gritsan, Marat M Khusniyarov, Alexander Witt, Alexey A Dmitriev, Elizaveta A Suturina, Nathan D D Hill, Tracey L Roemmele, Michael T, René T Boeré, Peter W Roesky, Andrey V Zibarev
The first lanthanide complexes with a redox-active sulphur diimide ligand, [LnCp*2(Me3SiN=)2S] (Ln = Sm, Eu, Yb; Cp* = η5-C5Me5), are reported. The complexes were synthesized using [LnCp*2(THF)2] and (Me3SiN=)2S and have been thoroughly characterized by single-crystal X-ray diffraction, EPR spectroscopy, UV-Vis-NIR electronic absorption spectroscopy and SQUID magnetometry. The results, as interpreted by CASSCF/SOC-RASSI calculations providing a non-perturbative treatment of spin-orbit coupling, indicate that these paramagnetic complexes are best described as Ln3+ and [(Me3SiN=)2S]-* adducts...
October 26, 2016: Chemistry: a European Journal
M Hossein Khalilian, Saber Mirzaei, Avat Arman Taherpour
The electronic features of anti-tumor agent, temozolomide, and its degradation products (MTIC and metabolite AIC) have been traced by means of UV absorption spectroscopy in vacuo and aqueous media. For comparison, electronic spectra of related structures and drugs (e.g., dacarbazine) were also investigated. These investigations were carried out using time-dependent density functional theory (TD-DFT) method while the conductor like screening model (COSMO) were applied for the inclusion of solvent effects in electronic spectra...
November 2016: Journal of Molecular Modeling
Hanns Moshammer, Stana Simic, Daniela Haluza
Ultra-Violet (UV) radiation covers the spectrum of wavelengths from 100 to 400 nm. The potency and biological activity for a variety of endpoints differ by wavelength. For monitoring and communication purposes, different UV action spectra have been developed. These spectra use different weighting functions. The action spectrum for erythemal dose is the most widely used one. This erythemal dose per time or dose-rate has been further simplified into a "UV index". Following this example, in our review we use the term "index" or (plural) "indices" in a more general description for all simplified single-value measures for any biologically effective UV dose, e...
October 24, 2016: International Journal of Environmental Research and Public Health
Masaru Fukushima, Takashi Ishiwata
We have generated SiCN in a supersonic free expansion, and measured the laser induced fluorescence (LIF) spectrum. Prior to the experiments, ab initio calculations were carried out to obtain the information necessary for searching for the LIF signals. In addition to the X̃ (2)Π state, the optimized structures of three excited states, (2)Δ, (2)Σ(+), and (2)Σ(-), have been obtained. Guided by the predictions, the LIF excitation spectrum of SiCN was observed in the UV region. The rotational structure of the 00(0) band with the origin, 29 261...
September 28, 2016: Journal of Chemical Physics
Moussa Gueye, Julien Nillon, Olivier Crégut, Jérémie Léonard
We describe a broadband transient absorption (TA) spectrometer devised to excite and probe, in the blue to UV range, vibrational coherence dynamics in organic molecules in condensed phase. A 800-nm Ti:Sa amplifier and a hollow fiber compressor are used to generate a 6-fs short pulse at 1 kHz. Broadband sum frequency generation with the fundamental pulse is implemented to produce a 400-nm, 8-fs Fourier limited short pulse. A UV-Vis white-light supercontinuum is implemented as a probe with intensity self-referencing to achieve a shot-noise-limited sensitivity...
September 2016: Review of Scientific Instruments
Chen Lin, Brian A Finney, Allan H Laufer, Josep M Anglada, Joseph S Francisco
An ab initio investigation has been employed to determine the structural and spectroscopic parameters, such as rotational constants, vibrational frequencies, vertical excitation energies, and the stability of the ethyl-water complex. The ethyl-water complex has a binding energy of 1.15 kcal⋅mol(-1). The interaction takes place between the hydrogen of water and the unpaired electron of the radical. This interaction is found to produce a red shift in the OH stretching bands of water of ca. 84 cm(-1), and a shift of all UV absorption bands to higher energies...
October 14, 2016: Journal of Chemical Physics
Maria A Trachsel, Timo Wiedmer, Susan Blaser, Hans-Martin Frey, Quansong Li, Sergi Ruiz-Barragan, Lluís Blancafort, Samuel Leutwyler
We have investigated the S0 → S1 UV vibronic spectrum and time-resolved S1 state dynamics of jet-cooled amino-keto 1-methylcytosine (1MCyt) using two-color resonant two-photon ionization, UV/UV holeburning and depletion spectroscopies, as well as nanosecond and picosecond time-resolved pump/delayed ionization measurements. The experimental study is complemented with spin-component-scaled second-order coupled-cluster and multistate complete active space second order perturbation ab initio calculations. Above the weak electronic origin of 1MCyt at 31 852 cm(-1) about 20 intense vibronic bands are observed...
October 7, 2016: Journal of Chemical Physics
Zhen Chen, Yuexiao Pan, Luqing Xi, Ran Pang, Shaoming Huang, Guokui Liu
In most Eu(3+) activated phosphors, only red luminescence from the (5)D0 is obtainable, and efficiency is limited by concentration quenching. Herein we report a new phosphor of Ca4LaO(BO3)3:Eu(3+) (CLBO:Eu) with advanced photoluminescence properties. The yellow luminescence emitted from the (5)D1,2 states is not thermally quenched at room temperature. The relative intensities of the yellow and red emission bands depend strongly on the Eu(3+) doping concentration. More importantly, concentration quenching of Eu(3+) photoluminescence is absent in this phosphor, and the stoichiometric compound of Ca4EuO(BO3)3 emits stronger luminescence than the Eu(3+) doped compounds of CLBO:Eu; it is three times stronger than that of a commercial red phosphor of Y2O3:Eu(3+)...
October 26, 2016: Inorganic Chemistry
Sepidar Sayyar, Miina Bjorninen, Suvi Haimi, Susanna Miettinen, Kerry Gilmore, Dirk W Grijpma, Gordon G Wallace
Conductive, flexible graphene/poly(trimethylene carbonate)(PTMC) composites (PTMC-CCG) were prepared. Addition of just 3 wt.% graphene to PTMC oligomers functionalized with methacrylate end-groups followed by UV-crosslinking results in more than 100% improvement in tensile strength and enhanced electrical conductivity by orders of magnitude without altering the processability of the host material. The addition of graphene also enhances mesenchymal stem cell (MSC) attachment and proliferation. When electrical stimulation via the composite material is applied, MSC viability is not compromised and osteogenic markers are upregulated...
October 26, 2016: ACS Applied Materials & Interfaces
Mengjun Tang, Xiaowen Sun, Shan Zhang, Juan Wan, Lin Li, Hong Ni
AIMS: The cell-surface display of chitinase Chi9602ΔSP was constructed on B. thuringiensis BMB171 by using two repeat N-terminal regions of autolysin (Mbgn)2 as the anchoring motif. This study aimed to prepare a chitinolytic whole-cell B. thuringiensis biocatalyst with improved catalytic and antifungal activities. METHODS AND RESULTS: The chitinase Chi9602ΔSP was displayed on the cell surface of B. thuringiensis BMB171 by using (Mbgn)2 as the anchoring motif. Immunofluorescence microscopic assays and flow cytometry confirmed that Chi9602ΔSP was anchored onto the surface of vegetative cells and spores...
October 26, 2016: Journal of Applied Microbiology
Thomas C Wilkes, Andrew J S McGonigle, Tom D Pering, Angus J Taggart, Benjamin S White, Robert G Bryant, Jon R Willmott
Here, we report, for what we believe to be the first time, on the modification of a low cost sensor, designed for the smartphone camera market, to develop an ultraviolet (UV) camera system. This was achieved via adaptation of Raspberry Pi cameras, which are based on back-illuminated complementary metal-oxide semiconductor (CMOS) sensors, and we demonstrated the utility of these devices for applications at wavelengths as low as 310 nm, by remotely sensing power station smokestack emissions in this spectral region...
October 6, 2016: Sensors
Stephanie Bath de Morais, Tatiana Arruda Campos Brasil de Souza, Ana Valeria Pereira Weiler, Mario Tyago Murakami
Aminotransferases are an important group of enzymes that catalyze the transfer of an amino group of an amino acid into a keto acid. Alanine aminotransferase from Trypanosoma cruzi (TcALAT) was cloned, overexpressed and purified. Far-UV Circular Dichroism (CD), Dynamic Light Scattering (DLS), Analytical Size Exclusion Chromatography (aSEC) and Small Angle X-ray Scattering (SAXS) provide data concerning TcALAT biophysical behavior. CD analysis displayed a typical spectrum of α-β proteins analogously as observed for other alanine aminotransferases...
October 25, 2016: Protein and Peptide Letters
Saket Kumar Singh, Bibhas Kumar Bhunia, Nandana Bhardwaj, Sween Gilotra, Biman B Mandal
Tunable repeated drug administration is often inevitable in number of pathological cases. Reloadable 3D matrices for sustained drug delivery are predicted as a prospective avenue to realize this objective. This study was directed towards sonication-induced fabrication of novel reloadable Bombyx mori silk fibroin (SF) (4, 6 and 8 wt%) hydrogel, injected within 3D porous (8 wt%) scaffolds. The focus was to develop a dual-barrier reloadable depot system for sustained molecular cargo-release. Both the varying SF concentration (4, 6 and 8 wt%) and the sonication time (30, 45 and 60 s) dictated the extent of cross-linking, β-sheet content and porosity (1-10 µm) influencing the release behavior of model molecules...
October 26, 2016: Molecular Pharmaceutics
Lingamallu Giribabu, Shivaprasad Achary B, Gokulnath Sabapathi, Samrat Ghosh, Madoori Mrinalini, Prasamthkumar Seelam
Charge-transfer (CT) complex of near-infrared absorbing systems hitherto unknown. Consequently, structural similarities between donor and acceptor are rather important to achieve this phenomenon. Herein, we reported electron donors such as non-fused diporphyrin-anthracene (DP), zinc diporphyrin-anthracene (ZnDP) and fused zinc diporphyrin-anthracene (FZnDP) in which FZnDP absorbs in NIR region and permits CT complex with electron acceptor, perylene diimide (PDI) in CHCl3 exclusively. UV-vis-NIR absorption, 1H nuclear magnetic resonance, nuclear overhauser effect spectroscopy and powder X-ray diffraction analysis demonstrated that the CT complex formation occurs by π-π stacking between perylene in FZnDP and PDI upon mixing together at 1:1 molar concentration in CHCl3, unlike non-fused ZnDP and DP...
October 26, 2016: Chemistry, An Asian Journal
Marlene Møller Madsen, Nykola C Jones, Steen Brøndsted Nielsen, Søren Vrønning Hoffmann
Solar mutagenesis via the formation of thymine dimer photoproducts is a primary cause of skin cancer. The aim of this study is to provide a direct method for following the development of photolesions in thymine single strands and to determine how the formation of these photoproducts depends on the excitation wavelength in the ultraviolet (UV) between 210 nm and 325 nm. Experiments were performed both with a 20 Hz pulsed, intense, tunable laser as well as UV lamps (at 254 nm and 302 nm), but we find that only the dose matters at these wavelengths for the yield of photoproducts...
October 26, 2016: Physical Chemistry Chemical Physics: PCCP
Ashlee J Howarth, Cassandra T Buru, Yangyang Liu, Ann M Ploskonka, Karel J Hartlieb, Monica McEntee, John J Mahle, James H Buchanan, Erin M Durke, Salih S Al-Juaid, J Fraser Stoddart, Jared B Decoste, Joseph T Hupp, Omar K Farha
A fullerene-based photosensitizer is incorporated postsynthetically into a Zr6-based MOF, NU-1000, for enhanced singlet oxygen production. The structural organic linkers in the MOF platform also act as photosensitizers which contribute to the overall generation of singlet oxygen from the material under UV irradiation. The singlet oxygen generated by the MOF/fullerene material is shown to oxidize sulfur mustard selectively to the less toxic bis(2-chloroethyl)sulfoxide with a half-life of only 11 min.
October 25, 2016: Chemistry: a European Journal
Alexander A Maini, Marc J George, Madhur P Motwani, Richard M Day, Derek W Gilroy, Alastair J O'Brien
Defects in neutrophil function have been implicated in a wide spectrum of clinical conditions. Several models are employed to study activated human neutrophils akin to those found at a site of inflammation. These include whole blood (WB) ex vivo stimulation with lipopolysaccharide (LPS) and in vivo techniques: cantharidin blister, skin windows and intra-dermal injection of UV-killed E.coli (UVKEc). Neutrophils obtained from these have never been compared. We compared the activation status of neutrophils from each technique in order to inform the optimal model for use in human studies...
2016: PloS One
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